Antigrippin instructions for use, blue capsules. Antigrippin-maximum - description of the drug, instructions for use, reviews

When and how are Antigrippin drugs used?

Antigrippin Anvi - symptomatic treatment of influenza and ARVI

Antigrippin Anvi is a complex drug for the treatment of acute respiratory viral infections and influenza. The drug has anti-inflammatory, antipyretic, analgesic and angioprotective effects. Relieves symptoms of ARVI and influenza, eliminates swelling of the nasal mucosa and paranasal sinuses, facilitating nasal breathing, reduces the intensity of headaches and muscle pain, reduces symptoms of general intoxication of the body, strengthens the walls blood capillaries, reducing their permeability and fragility.

Antigrippin Anvi is not active against influenza and ARVI viruses, since it does not contain antiviral drugs. Used only as a symptomatic drug.

Before you continue reading: If you are looking effective method to get rid of runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to check out Book section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

The active ingredients of the drug are contained in two types of capsules: green and white. The ingredients are divided into two groups, based on the compatibility of medicinal substances, and to reduce the irritating effect of the drug on the mucous membrane gastrointestinal tract(to prevent the development erosive gastritis and gastric ulcer). Antigrippin Anvi capsules dissolve in small intestine, where they no longer provide irritating effect to the mucous membrane.

Antigrippin Anvi includes:

Green capsules:

acetylsalicylic acid – 0.25 g (anti-inflammatory, antipyretic, analgesic effect);
ascorbic acid– 0.3 g (participates in the regulation of redox processes in the human body, affects carbohydrate metabolism, regulates blood clotting processes, strengthens the walls of blood capillaries);
rutin – 0.02 g (affects rheological properties blood, reduces the fragility and permeability of the walls of blood capillaries);
Excipients: potato starch, sugar, calcium stearate, talc.

White capsules:

metamizole sodium (analgin) – 0.25 g (anti-inflammatory, analgesic effect);
diphenhydramine (diphenhydramine) – 0.02 g (antihistamine, antiallergic effect);
calcium gluconate – 0.1 g (strengthens capillary walls, in combination with antihistamines has an antiallergic effect);
excipients: sugar, potato starch, calcium stearate, talc.

Contraindications to the use of Antigrippin Anvi are:

intolerance to one of the components of the drug;
impaired liver and kidney function;
disorders of the blood coagulation system;
bronchial asthma and allergic diseases;
The drug is not intended for children under 15 years of age.

In case of adverse reactions When treating with Antigrippin Anvi, you must stop taking the drug and consult your doctor.

In case of overdose, nausea, vomiting, abdominal pain, general weakness, headache. In this case, it is necessary to discontinue the drug, perform gastric lavage, and prescribe enterosorbents - activated carbon, polysorb. In case of pathological reactions from internal organs Symptomatic treatment is recommended.

Antigrippin Anvi is not recommended to be taken simultaneously with non-steroidal anti-inflammatory drugs (analgin, paracetamol, ortofen, diclofenac), since in this case the likelihood of developing gastrointestinal bleeding increases. When taking the drug simultaneously with sedative drugs, pathological effects on the central nervous system may be observed. Simultaneous use of Antigrippin Anvi and anti-tuberculosis antibacterial agents(rifampicin), as well as barbiturates (phenobarbital), can lead to significant impairment of liver and kidney function.

During pregnancy and women breastfeeding breast milk Children under one year of age are not prescribed the drug. The components of the drug penetrate the placental barrier and can adversely affect the development of the fetus. Antigrippin Anvi is used to treat adults and children over 15 years of age. The drug is prescribed according to the following scheme: one green capsule and one white capsule, orally, after meals. Wash it down boiled water, take two to three times a day (at the indicated dosage). Duration of treatment is from three to five days.

With absence therapeutic effect, persistence of symptoms of the disease, increased body temperature, and the appearance of infectious complications, consultation with the attending physician is necessary.

Prescribe with caution to persons managing vehicles.

The drug is released in pharmacy chain without a doctor's prescription.

Release form: available in cardboard packaging that contains green and white capsules, 10 capsules of each type in blister packs.

AGRI (homeopathic anti-grippin) for the prevention and treatment of colds and flu

AGRI is a homeopathic medicine. It contains plant and mineral components. The drug has anti-inflammatory, antipyretic, immunomodulatory effects. Increases the adaptogenic properties of the body, helps reduce symptoms of intoxication during acute respiratory viral infections and influenza. Reduces the intensity of headaches and muscle pain, has an antitussive effect, and prevents the development of complications in ARVI and influenza.

AGRI has a stimulating effect on immune system, is used to prevent influenza and acute respiratory viral infections during seasonal epidemics.

Compound:

Ingredients of plant origin:

Arnica – strengthens the walls of blood capillaries, reduces their permeability, and has a moderate analgesic effect.
Rhus toxicodendron – has anti-inflammatory, antipyretic, analgesic effects.
Actonium – reduces symptoms of intoxication in acute respiratory viral infections and influenza, has an antitussive effect.

Mineral components:

Arsenicum album – has an immunomodulatory, anti-inflammatory effect.
Mercurius solubilis – increases the body's resistance to viral infections.

AGRI (homeopathic anti-grippin) is used for the prevention and treatment of influenza and acute respiratory viral infections of various etiologies.

The components of the drug Antigrippin Agri have a low concentration (1000 times dilution of the active ingredients), which ensures minimal impact of the drug on metabolic processes body and contributes to its good tolerance.

"Agri" is taken sublingually (under the tongue) until completely dissolved. For children, the drug is dissolved in a small amount of water. Before using the product, you should read the instructions for use and consult with your doctor.

For adults and children over 7 years old therapeutic dosage The drug is 7 granules under the tongue until completely dissolved 3 to 5 times a day. The duration of the course of treatment is determined by the attending physician.

For the prevention of acute respiratory viral infections and influenza for children over 7 years of age and adults, homeopathic Antigrippin (Agri) is prescribed in a dosage of 7 granules under the tongue until completely dissolved 1 to 2 times a day. The prophylactic course usually lasts from 2 to 4 months.

For children from 1 to 7 years of age, the dose of the drug is calculated according to following diagram: one granule per year of a child’s life. Antigrippin Agri is taken sublingually (or diluted in a small amount of water) 3 to 5 times a day. For the prevention of acute respiratory viral infections and influenza for children aged 1 to 7 years, the dose of the drug is calculated according to the same scheme. Antigrippin Agri is taken sublingually (or diluted in a small amount of water) 1 to 2 times a day.

"Agri" is available in the form of granules of 10 mg in a polymer case, located in a cardboard package.

The drug is dispensed in pharmacies without a doctor's prescription due to the lack of side effects and hypoallergenic.

Storage conditions: at temperatures up to 25 degrees Celsius, in a dry, dark place, away from heating devices and sun rays. The shelf life is 3 years.

Antigrippin Maximum is an effective treatment for influenza and ARVI

Antigrippin Maximum is a combined antiviral, anti-inflammatory, antipyretic, angioprotective drug used to treat symptoms of influenza and acute respiratory viral infections.

The drug is available in the form of blue and red capsules. The components of the drug are divided into two groups for a more effective therapeutic effect on the symptoms of ARVI and influenza and reducing the risk of adverse reactions.

The drug Antigrippin has therapeutic effect for symptoms of acute respiratory viral infections and influenza.

The drug is available in a cardboard package containing 20 capsules: 10 capsules of blue color and 10 red capsules. The capsules are placed in blister packaging.

Antigrippin Maximum is also available in powder form for preparation medicinal solution(flavoured with lemon, raspberry, blackcurrant, honey). The prepared solution for oral administration is transparent or yellowish in color; slight turbidity of the solution and the presence of undissolved particles are allowed.

Composition “Maximum”: paracetamol – 0.36 g, rimantadine hydrochloride – 0.05 g, ascorbic acid – 0.3 g, loratadine – 0.003 g, rutoside – 0.02 g, calcium gluconate (in the form of monohydrate) – 0.1.

Excipients: aspartame, hypromellose, silicon dioxide, lactose, flavoring (raspberry, lemon or currant).

Available in cardboard packages containing 3, 6, 8, 12 or 24 sachets of medicinal substance. The weight of the bag is 5 g.

The components of the drug are absorbed in the small intestine, partially bind to blood plasma proteins, the metabolism of the drug components occurs mainly in the liver, and derivatives of drug metabolism are excreted from the body by the kidneys.

Indications for prescribing the drug Antigrippin Maximum are: acute respiratory viral infections, influenza, acute respiratory infections, accompanied elevated temperature body, headaches and muscle pain, general intoxication of the body.

Remantadine, which is part of the drug, has an antiviral etiotropic effect on influenza A viruses.

Contraindications to the use of Antigrippin Maximum are:

intolerance to any component of the drug;
liver dysfunction ( chronic hepatitis, cirrhosis) and kidneys (pyelonephritis, glomerulonephritis, chronic renal failure);
disorders of the blood coagulation process (hemophilia, thrombocytopenia);
erosive diseases of the gastrointestinal tract;
allergic diseases in the patient's history (bronchial asthma, hay fever, Quincke's edema, anaphylactic shock);
the drug is not intended for children under 12 years of age - Antigrippin Maximum (powder for solution) and adolescents under 18 years of age - Antigrippin Maximum (capsules);
Antigrippin Maximum is contraindicated during pregnancy and in women breastfeeding children under one year of age, due to negative influence on the development of the fetus and children in the first year of life;
the drug is not recommended for coronary disease heart and high blood pressure;
The drug is not recommended for patients suffering from oncological diseases(the drug itself carcinogenic effect does not provide);
It is not recommended to take alcohol during treatment, as in this case it increases toxic effect paracetamol on the liver and kidneys.

Antigrippin Maximum (capsules and powder) is prescribed with caution to persons driving vehicles, since the components of the drug may affect reaction speed and attention.

In case of an overdose of the drug, nausea, vomiting, general weakness, tachycardia, arrhythmia, headaches, liver and kidney dysfunction may occur. In case of overdose, the patient needs to consult a doctor. It is recommended to perform gastric lavage and the use of enterosorbents (activated carbon, polysorb).

Antigrippin Maximum is taken according to the following scheme:

Capsules - for adults and adolescents over 18 years of age, one blue capsule and one red capsule are prescribed 2 to 3 times a day. The drug is taken orally with water.

Powder - adults and children over 12 years of age are prescribed one sachet 2 to 3 times a day. Dissolve the contents of the sachet in 200 ml hot water, stir and take hot orally.

Antigrippin Maximum is taken for 3-5 days. If there is no therapeutic effect, symptoms of the disease persist, or body temperature rises, it is recommended to consult a doctor. With the development of infectious complications, the prescription of antibiotics is required. medicines, since Antigrippin is not an antibiotic. Frequent infectious complications with ARVI and influenza are sinusitis and sinusitis. For the treatment of sinusitis and sinusitis of various etiologies, it is recommended to use medications such as Sinuforte and Rinofluimucil.

Antigrippin Maximum is available in pharmacies without a doctor's prescription.

The shelf life of the drug is 2 years. It is recommended to store in a dry, dark place out of reach of children. Storage temperature no more than 25 degrees Celsius.

AntiGrippin "Effervescent tablets" - a convenient form for the treatment of colds and flu

AntiGrippin in the form of effervescent tablets is perhaps one of the most effective and fast-acting options for this drug.

More detailed information You can find out about this type of AntiGrippin on the manufacturer’s website antigrippin-np.ru/about.html - there are quite a lot of different flavors of the drug (effervescent tablets, including powders for dissolution). Instructions for use are described in detail. And overall a very informative and interesting site on this species Anti-Grippin.

Manufacturers

We would also like to note that different types drug Antigrippin different manufacturers, in particular:

AntiGrippin from Natur Product (Europe) – effervescent tablets, powders

Antigrippin – Maximum from AnviLab (Russia) – capsules and powders

AGRI (homeopathic anti-grippin) from Materia Medica(Russia) – granules

Which Antigrippin do you prefer and which manufacturer do you prefer, please speak out in the comments below.

Are there any analogues?

There are no direct analogs of Antigrippin. But to some extent, similar medications can be found in their anti-cold properties, for example, Gripgo, Fervex, Efferalgan with vitamin C,

A combined drug with antiviral, interferonogenic, antipyretic, anti-inflammatory, analgesic, antiallergic and angioprotective effects.

Paracetamol has antipyretic, analgesic and anti-inflammatory effects.

Rimantadine is an antiviral agent that is active against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage virus replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect.

Ascorbic acid is involved in the regulation of redox processes, normalizes capillary permeability, blood clotting, tissue regeneration, and activates the immune system.

Loratadine is a histamine H1 receptor blocker that prevents the development of tissue edema associated with the release of histamine.

Rutoside is an angioprotector. Reduces increased capillary permeability, reducing its swelling and inflammation, strengthens vascular wall. It has an antiplatelet effect and increases the degree of red blood cell deformation.

Calcium gluconate prevents the development of increased permeability and fragility of blood vessels, which cause hemorrhagic processes in influenza and ARVI, and also restores capillary circulation and has an antiallergic effect (the mechanism is unclear).

Pharmacokinetics

Paracetamol

Absorption is high. Based on the results of the clinical trials when taking capsules, Cmax of paracetamol in blood plasma is achieved after 1.2±0.72 hours and is 5.01±1.7 mcg/ml, T1/2 is 3.04±1.01 hours.

Plasma protein binding - 15%. Penetrates through the BBB.

Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercaptopuric acid. The main isoenzymes of cytochrome P450 for this path metabolism are the isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

In elderly patients, drug clearance decreases and T1/2 increases.

Rimantadine

After oral administration, it is almost completely absorbed from the intestine. Absorption is slow. According to the results of clinical studies, when taking capsules, Cmax in blood plasma is achieved after 4.53±2.52 hours and is 68.2±26.6 ng/ml; T 1/2 is 30.51 ±9.83 hours.

Plasma protein binding is about 40%. V d - 17-25 l/kg. The concentration in nasal secretions is 50% higher than the plasma concentration.

Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% unchanged.

In chronic renal failure, T1/2 increases by 2 times. In patients with renal failure and in elderly patients, toxic concentrations may accumulate if the dose is not adjusted in proportion to the decrease in clearance. Hemodialysis has little effect on the clearance of rimantadine.

Ascorbic acid

Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum). Plasma protein binding - 25%. The normal concentration of ascorbic acid in plasma is approximately 10-20 μg/ml. T max in blood plasma after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. At deficiency states leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, unchanged and in the form of metabolites.

Gastrointestinal diseases ( peptic ulcer stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine.

Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Loratadine

After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. According to the results of clinical studies, when taking capsules, Cmax in blood plasma is achieved after 2.92±1.31 hours and is 2.36±1.53 ng/ml, T1/2 is 12.36±6.84 hours.

Plasma protein binding - 97%. Metabolized in the liver to form the active metabolite descarboxyloratadine with the participation of cytochrome isoenzymes CYP3A4 and, to a lesser extent, CYP2D6. Does not penetrate the BBB.

Excreted by the kidneys and bile.

In elderly patients, Cmax increases by 50%.

In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Tmax in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and to a lesser extent by the kidneys. T 1/2 - 10-25 hours.

Calcium gluconate

Approximately 1/5-1/3 of orally administered calcium gluconate is absorbed into the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) through the intestines.

Release form

Two types of capsules.

Capsules P hard gelatin, blue, size No. 0; contents of capsules - a mixture of powder and/or granules, white or white with a creamy or pinkish tint, granules irregular shape, different sizes, the presence of lumps is allowed.

Excipients: pregelatinized starch, lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

Capsule shell composition: gelatin, patented blue dye (E131), titanium dioxide (E171).

Capsules P hard gelatin, red, size No. 0; the contents of the capsules are a mixture of powder and/or granules of yellow with a greenish tint and white, irregularly shaped granules of different sizes, the presence of lumps is allowed.

Excipients: potato starch, magnesium stearate.

Composition of the capsule shell: gelatin, yellow iron oxide dye (E172), red iron oxide dye (E172), crimson dye (Ponceau 4R) (E124), titanium dioxide (E171).

20 pcs. (10 caps. P in a separate blister pack (1) and 10 caps. P in a separate blister pack (1)) - cardboard packs.

Dosage

The drug should be taken orally after meals.

Adults Antigrippin-maximum capsules are prescribed 1 blue capsule P and 1 red capsule P 2-3 times a day until the symptoms of the disease disappear. Take the capsules with water.

For adults and children over 12 years of age, Antigrippin-maximum in powder form for the preparation of a solution for oral administration is taken 1 sachet 2-3 times a day until the symptoms of the disease disappear. Preparation of the solution: dissolve the contents of 1 sachet in 1 glass of boiled hot water. Serve hot, after stirring.

The duration of treatment is 3-5 days (no more than 5 days). If no improvement in well-being is observed within 3 days after starting to use the drug, the patient should stop taking the drug and consult a doctor.

Overdose

Symptoms: pallor is possible in the first 24 hours skin, nausea, diarrhea, vomiting, pain in epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of associated chronic diseases. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: administration of SH-group donors and precursors for the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic activities(further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

In case of overdose of the drug, the patient needs to consult a doctor.

Interaction

If it is necessary to use Antigrippin-Maximum simultaneously with other drugs, the patient should consult a doctor.

Paracetamol

Reduces the effectiveness of uricosuric drugs.

Concomitant use of paracetamol in high doses enhances the effect of anticoagulant drugs.

Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose.

At simultaneous use with metoclopramide it is possible to increase the rate of absorption of paracetamol.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity of paracetamol.

Ascorbic acid

Increases the plasma concentration of benzylpenicillin.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron). May increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria when treated with salicylates and sulfonamides short acting, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have alkaline reaction(including alkaloids).

Reduces the blood concentration of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces therapeutic effect antipsychotic drugs(neuroleptics) phenothiazine derivatives.

Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

Rimantadine

Enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Loratadine

Inhibitors of CYP3A4 and CYP2D6 increase plasma concentrations of loratadine.

Side effects

From the side of the central nervous system: rarely - increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face.

From the outside digestive system: possible (with a duration of use of more than 7 days) - damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

From the hematopoietic system: possible (with a duration of use of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

From the urinary system: moderate pollakiuria is possible.

Allergic reactions: rarely - skin rash, itching, urticaria.

Other: inhibition of the function of the pancreatic insular apparatus (hyperglycemia, glycosuria).

If side effects occur, the patient should immediately stop taking the drug and consult a doctor.

Indications

etiotropic treatment of influenza type A in adults;
symptomatic treatment colds, influenza and ARVI, accompanied by fever, muscle pain, headache, chills in adults.

Contraindications

erosive and ulcerative lesions Gastrointestinal tract in the acute phase;
gastrointestinal bleeding;
hemophilia;
hemorrhagic diathesis;
hypoprothrombinemia;
vitamin K deficiency;
diseases thyroid gland;
acute and exacerbation of chronic kidney diseases (incl. acute glomerulonephritis, acute pyelonephritis);
renal failure;
nephrourolithiasis;
acute and exacerbation of chronic liver diseases (incl. acute hepatitis);
portal hypertension;
chronic alcoholism;
hypercalcemia;
severe hypercalciuria;
sarcoidosis;
simultaneous administration cardiac glycosides (risk of arrhythmia);
lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
pregnancy;
lactation period ( breast-feeding);
children's and adolescence up to 18 years (for capsules);
increased sensitivity to the components of the drug.

Use the drug with caution for epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history), mild to moderate hypercalciuria; in elderly patients with arterial hypertension(increases the risk of developing hemorrhagic stroke, due to the rimantadine included in the drug).

If you have the diseases or conditions listed above, the patient should consult a doctor before taking the drug.

Features of application

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Use for liver dysfunction

Contraindicated in acute or exacerbation of chronic liver diseases (including acute hepatitis) and portal hypertension.

Use for renal impairment

Contraindicated in acute and exacerbation of chronic kidney diseases (including acute glomerulonephritis) and in renal failure.

Use in children

The drug is prescribed to children over 12 years of age.

special instructions

At long-term use(more than 7 days) possible exacerbation of chronic concomitant diseases, in elderly patients with arterial hypertension, the risk of developing hemorrhagic stroke increases (due to the rimantadine hydrochloride included in the drug).

Persons prone to drinking alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

The drug should not be used in the presence of metastatic tumors.

Antigrippin-maximum does not have carcinogenic properties.

Use in pediatrics

The drug in powder form should not be administered to children under 12 years of age.

The drug in capsule form is contraindicated in children and adolescents under the age of 18 years.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, patients should be careful when driving vehicles and other potentially dangerous species activities requiring high concentration attention and speed of psychomotor reactions.

Disease class

Not indicated. See instructions

Clinical and pharmacological group

Not indicated. See instructions

Pharmacological action

Not indicated. See instructions

Pharmacological group

Not indicated. See instructions

Antigrippin-maximum capsule

Instructions for medical use drug

Description of pharmacological action

A combined drug with antiviral, interferonogenic, antipyretic, anti-inflammatory, analgesic, antiallergic and angioprotective effects.

Indications for use

Etiotropic treatment of influenza type A in adults;

Symptomatic treatment of colds, flu and ARVI, accompanied by fever, muscle pain, headache, chills in adults.

Release form

set of capsules; contour packaging 10, cardboard pack 1;

Pharmacodynamics

Paracetamol has antipyretic, analgesic and anti-inflammatory effects.

Rimantadine is an antiviral agent that is active against the influenza A virus. By blocking the M2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of alpha and gamma interferons. For influenza caused by virus B, rimantadine has an antitoxic effect.

Ascorbic acid is involved in the regulation of redox processes, normalizes capillary permeability, blood clotting, tissue regeneration, and activates the immune system.

Loratadine is a histamine H1 receptor blocker that prevents the development of tissue edema associated with the release of histamine.

Rutoside is an angioprotector. Reduces increased capillary permeability, reducing swelling and inflammation, strengthens the vascular wall. It has an antiplatelet effect and increases the degree of red blood cell deformation.

Pharmacokinetics

Paracetamol

Absorption is high. According to the results of clinical studies, when taking capsules, Cmax of paracetamol in blood plasma is achieved after 1.2±0.72 hours and is 5.01±1.7 mcg/ml, T1/2 is 3.04±1.01 hours.

Plasma protein binding - 15%. Penetrates through the BBB.

Metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercaptopuric acid. The main isoenzymes of cytochrome P450 for this metabolic pathway are the isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). With glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways include hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated metabolites of paracetamol (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

Excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

In elderly patients, drug clearance decreases and T1/2 increases.

Rimantadine

Plasma protein binding is about 40%. Vd - 17-25 l/kg. The concentration in nasal secretions is 50% higher than the plasma concentration.

Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% unchanged.

Ascorbic acid

Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum). Plasma protein binding - 25%. The normal concentration of ascorbic acid in plasma is approximately 10-20 μg/ml. Tmax in blood plasma after oral administration is 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.

Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestines.

Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.

Loratadine

Excreted by the kidneys and bile.

In elderly patients, Cmax increases by 50%.

In patients with chronic renal failure and during hemodialysis, the pharmacokinetics remain virtually unchanged.

Tmax in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and to a lesser extent by the kidneys. T1/2 - 10-25 hours.

Calcium gluconate

Approximately 1/5-1/3 of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with calcium deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) through the intestines.

Use during pregnancy

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Contraindications for use

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- gastrointestinal bleeding;
- hemophilia;
- hemorrhagic diathesis;
- hypoprothrombinemia;
- vitamin K deficiency;
- diseases of the thyroid gland;
- acute and exacerbation of chronic kidney diseases (including acute glomerulonephritis, acute pyelonephritis);
- renal failure;
- nephrourolithiasis;
- acute and exacerbation of chronic liver diseases (including acute hepatitis);
- portal hypertension;
- chronic alcoholism;
- hypercalcemia;
- severe hypercalciuria;
- sarcoidosis;
- simultaneous use of cardiac glycosides (risk of arrhythmia);
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents up to 18 years of age (for capsules);
- hypersensitivity to the components of the drug.

Use the drug with caution for epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, dehydration, electrolyte disturbances (risk of developing hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history) , mild to moderate hypercalciuria; in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases due to the rimantadine included in the drug).

If you have the diseases or conditions listed above, the patient should consult a doctor before taking the drug.

Side effects

From the side of the central nervous system: rarely - increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face.

From the digestive system: possible (with a duration of use of more than 7 days) - damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

From the hematopoietic system: possible (with a duration of use of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

From the urinary system: moderate pollakiuria is possible.

Allergic reactions: rarely - skin rash, itching, urticaria.

Other: inhibition of the function of the pancreatic insular apparatus (hyperglycemia, glycosuria).

If side effects occur, the patient should immediately stop taking the drug and consult a doctor.

Directions for use and doses

The drug should be taken orally after meals.

Adults Antigrippin-maximum capsules are prescribed 1 blue capsule P and 1 red capsule P 2-3 until the symptoms of the disease disappear. Take the capsules with water.

Overdose

Symptoms: in the first 24 hours, pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases are possible. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: administration of SH-group donors and precursors for the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

In case of overdose of the drug, the patient needs to consult a doctor.

Interactions with other drugs

If it is necessary to use Antigrippin-Maximum simultaneously with other drugs, the patient should consult a doctor.

Paracetamol

Reduces the effectiveness of uricosuric drugs.

Concomitant use of paracetamol in high doses enhances the effect of anticoagulant drugs.

When used simultaneously with metoclopramide, it is possible to increase the rate of absorption of paracetamol.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity of paracetamol.

Ascorbic acid

Increases the plasma concentration of benzylpenicillin.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron). May increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids).

Reduces the blood concentration of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) phenothiazine derivatives.

Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

Rimantadine

Enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Loratadine

Inhibitors of CYP3A4 and CYP2D6 increase plasma concentrations of loratadine.

Special instructions for use

With long-term use (more than 7 days), exacerbation of chronic concomitant diseases is possible; in elderly patients with arterial hypertension, the risk of developing hemorrhagic stroke increases (due to the rimantadine hydrochloride included in the drug).

Persons prone to drinking alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

The drug should not be used in the presence of metastatic tumors.

Antigrippin-maximum does not have carcinogenic properties.

Use in pediatrics

The drug in powder form should not be administered to children under 12 years of age.

The drug in capsule form is contraindicated in children and adolescents under the age of 18 years.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, patients should be careful when driving vehicles and other potentially dangerous activities that require high concentration and speed of psychomotor reactions.

Storage conditions

The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25°C.

Best before date

ATX classification:

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Antigrippin Maximum- complex medicinal product, assigned to symptomatic treatment influenza and ARVI. The predominant influenza virus that caused epidemic morbidity in 2013 is A(H1N1)pdm09 (data from the Russian Ministry of Health and Social Development). Remantadine, which is part of Antigrippin, has an antiviral effect against these influenza pathogens. In addition, the drug has an antipyretic and anti-inflammatory effect, and reduces intoxication.

In the pharmacy chain, the medicine is presented in red and blue capsules (blisters), as well as sachets (powder for preparing a medicinal solution).

How does Antigrippin work for influenza, ARVI?

The combined effect is achieved through exposure to 6 active ingredients, included in the drug Antigrippin:
Remantadine- immunomodulatory, antiviral drug. Suppresses the reproduction of viruses in the early stages, even after they penetrate into healthy cells, increases the synthesis of endogenous interferon, stimulates the activity of lymphocytes, and prevents the release of viral agents from their cells.

Loratadine - antihistamine 2 generations. Prevents the release of serotonin, histamine, bradykinin. Loratadine has an antiallergic effect, reduces tissue swelling by reducing vascular permeability, has an antipruritic, antiexudative effect, and does not cause drowsiness.

Paracetamol- an anti-inflammatory agent that has an antipyretic and analgesic effect. Available in various combination drugs for the treatment of colds.

Calcium gluconate- has an antiallergic, anti-edematous effect, reduces capillary permeability, promotes relief inflammatory process.

Rutoside- helps reduce capillary fragility, improve microcirculation, eliminates tissue swelling.

Vitamin C- immunostimulating effect. Regulates metabolic processes, protects cells from pathological effects free radicals, increases the detoxification properties of liver cells, stimulates immune reactions and release of interferons.

Indications for use

Antigrippin Maximum is prescribed for the symptomatic treatment of acute respiratory viral infections and influenza in adults, as well as children over 12 years of age.

Mode of application

Antigrippin Maximum capsules are prescribed according to the following scheme: capsules are taken orally with water (do not chew!). Single dosage: 1 capsule. red and 1 cap. of blue color. For children over 12 years of age, adults are recommended to take 1 single dosage of the medicine 2-3 times a day, after meals.

Antigrippin Maximum powder is used according to the following scheme: immediately before use, dilute the contents of the sachet in a glass of water (50-60 degrees C). Take orally immediately hot after eating. The recommended dose of the drug is 2-3 packs. in a day. The course of treatment with the drug is 3 - 5 days.

Contraindications for use

Peptic ulcer (exacerbation period).
Gastrointestinal bleeding.
Decompensated diseases of the liver, kidneys, cardiovascular system.
Thyrotoxicosis.
Individual hypersensitivity.
Chronic alcoholism.
Malignant neoplasms.
Atherosclerosis cerebral vessels, epilepsy.
Antigrippin is not recommended for young patients under 12 years of age.
Period of pregnancy, lactation.

Side effects

During treatment, side effects are possible: dizziness, headaches, increased excitability, allergic reactions(Quincke's edema, urticaria), indigestion, lack of appetite, anemia, leukopenia.

Overdose

Exceeding the recommended dosage may be accompanied by nausea, vomiting, abdominal pain, pallor, drowsiness, and rapid heartbeat. Symptomatic therapy is carried out, enterosorbents are used: Polysorb, Activated carbon, Lactofiltrum.

Analogues of Antigrippin Maximum

Coldrex, Fervex, TeraFlu have similar pharmacological properties. The drugs have a complex anti-inflammatory, antipyretic effect, but do not contain antiviral agents. Price foreign analogues slightly higher than the price of Antigrippin Maximum.

Is it possible to prescribe Antigrippin Maximum during pregnancy and lactation?

The use of the drug is absolutely contraindicated during pregnancy. During lactation, treatment is possible only if breastfeeding is temporarily stopped.

Storage conditions

At temperatures up to 25 degrees. C. Away from sunlight, low humidity. The shelf life of the medicine is 2 years.

Price of medicine

Antigrippin Maximum, sachets No. 3 - 90 - 105 rubles.

Antigrippin Maximum, red capsules - No. 10 and blue capsules - No. 10 (blisters) - 260 - 275 rubles.

Capsules Antigrippin Maximum is a combined drug used for symptomatic and etiotropic treatment of acute respiratory infections. viral diseases and flu. The drug contains 6 active ingredients: paracetamol, rimantadine, loratadine, ascorbic acid (vitamin C), rutoside and calcium gluconate. The drug has antiviral, immunostimulating, antihypertensive, analgesic and some anti-inflammatory effects. In addition, the drug Antigrippin Maximum has a pronounced antihistamine and angioprotective effect, helps reduce swelling and hyperemia of the mucous membranes respiratory tract. Mechanism of action and therapeutic effects drugs are based on pharmacological properties active components included in its composition.

Rimantadine – medicinal substance, an adamantane derivative with a pronounced antiviral effect. Rimantadine also has antitoxic and immunomodulatory effects. The drug has antiviral activity against strains of influenza A virus, herpes viruses type I and II and viruses tick-borne encephalitis. Mechanism antiviral action The drug is based on its ability to suppress the specific reproduction of viruses on early stage, in particular, the effect of the drug occurs in the period after the virus enters the cell and before the initial transcription of RNA. In addition, the drug stimulates the synthesis and release of interferons, in particular alpha and gamma interferon, and increases functional activity T and B lymphocytes, as well as NK cells.

The mechanism of action of the drug is also associated with its ability to increase the pH of endosomes, which have vacuole membranes and surround viruses after penetration into the cell. Due to the increase in pH, acidification in these vacuoles is prevented and the fusion of the virus shell with the endosome membrane is blocked, thereby preventing the transfer of the genetic material of the virus into the cell cytoplasm. In addition, the drug reduces the release of viral particles from the cell, thus interrupting the transcription of the viral genome.

Paracetamol is a drug from the group of nonsteroidal anti-inflammatory drugs that has pronounced analgesic and antipyretic (antipyretic) activity. The anti-inflammatory activity of the drug is weakly expressed, this is due to the ability of cellular peroxidases to inactivate paracetamol. The mechanism of action of the drug is associated with its ability to inhibit the enzymatic activity of cyclooxygenase, resulting in metabolic disorders arachidonic acid and synthesis of such biologically active substances such as prostaglandins, prostacyclins and thromboxane. Paracetamol is a non-selective non-steroidal anti-inflammatory drug; it equally inhibits the activity of both isoforms of cyclooxygenase - cyclooxygenase-1 and cyclooxygenase-2. The antipyretic effect of the drug is based on its ability to reduce the amount of prostaglandins in the thermoregulation center in the hypothalamus, as a result of which the sensitivity of receptors to the action of pyrogens decreases. Analgesic effect The drug is carried out by reducing the amount of prostaglandins in the tissues of the central nervous system, as a result of which the sensitivity of receptors to chemical irritants is reduced and the intensity of pain is reduced.

Loratadine is a drug of the group antihistamines second generation. Loratadine by chemical structure is a derivative of piperidine. The drug helps eliminate the effects caused by histamine, including loratadine relieves spasm of the smooth muscle layer of blood vessels, prevents and reduces tissue swelling, and reduces pathologically increased permeability of the vascular wall. In addition, the drug is characterized by a pronounced antiexudative, antipruritic and antiallergic effect. The mechanism of action of the drug is due to its ability to competitively block H1-histamine receptors, while the drug affects primarily peripheral H1-histamine receptors. The effect of the drug on the central nervous system is insignificant, this is due to the low affinity of the loratadine molecule for histamine receptors, located in the central nervous system, and the low degree of penetration of loratadine through the blood-brain barrier.

Calcium gluconate is a drug that has antiexudative, antiedematous and antiallergic effects. The anti-exudative and anti-edematous effect of the drug is carried out by increasing the elasticity of blood vessels and reducing the increased permeability of the vascular wall at the site of inflammation. Due to the reduction in exudative phenomena, there is a decrease in the intensity of the inflammatory process and an improvement in the condition of patients suffering from acute respiratory diseases. The mechanism of the antiallergic effect of the drug has not been studied.

Ascorbic acid (vitamin C) – has angioprotective, antioxidant and immunostimulating effects, regulates carbohydrate metabolism and takes part in various redox reactions in the body. Vitamin C protects cells from negative impact free radicals and peroxide compounds, reduces pathologically increased permeability of the vascular wall, reduces exudative phenomena, increases the elasticity of blood vessels. By activating specific enzymes, it increases the detoxification function of the liver and helps increase the synthesis of prothrombin. In addition, ascorbic acid affects cellular and humoral immunity, chemotaxis and migration of lymphocytes. Vitamin C increases the synthesis and stimulates the release of interferon, increases the phagocytic activity of neutrophils.

Rutoside is a flavonoid that has a pronounced angioprotective effect, reduces vascular permeability, increases elasticity and reduces vascular fragility. In addition, rutoside helps reduce the intensity of the inflammatory process, eliminates tissue swelling, and improves microcirculation at the site of inflammation. The drug leads to a decrease in red blood cell aggregation and increases the degree of their deformation. It acts primarily on the vascular wall of capillaries and veins.

Indications for use

Indications for use of the drug Antigrippin Maximum are:

etiotropic treatment of influenza type A in adults;
symptomatic treatment of colds, flu and ARVI, accompanied by fever, muscle pain, headache, chills in adults.

Mode of application

Antigrippin Maximum should be taken orally after meals.

Adults Antigrippin-maximum capsules are prescribed 1 blue capsule P and 1 red capsule P 2-3 times a day until the symptoms of the disease disappear. Take the capsules with water.

Side effects

From the side of the central nervous system: rarely - increased excitability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the face.

From the digestive system: possible (with a duration of use of more than 7 days) - damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

From the hematopoietic system: possible (with a duration of use of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

From the urinary system: moderate pollakiuria is possible.

Allergic reactions: rarely - skin rash, itching, urticaria.

Other: inhibition of the function of the pancreatic insular apparatus (hyperglycemia, glycosuria).

If side effects occur, the patient should immediately stop taking the drug and consult a doctor.

Contraindications

Contraindications to the use of the drug Antigrippin Maximum are: erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; gastrointestinal bleeding; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; vitamin K deficiency; thyroid diseases; acute and exacerbation of chronic kidney diseases (including acute glomerulonephritis, acute pyelonephritis); renal failure; nephrourolithiasis; acute and exacerbation of chronic liver diseases (including acute hepatitis); portal hypertension; chronic alcoholism; hypercalcemia; severe hypercalciuria; sarcoidosis; simultaneous use of cardiac glycosides (risk of arrhythmia); lactose intolerance, lactase deficiency, glucose-galactose malabsorption; pregnancy; lactation period (breastfeeding); children and adolescents up to 18 years of age (for capsules); hypersensitivity to the components of the drug.

Use the drug with caution for epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, dehydration, electrolyte disturbances (risk of developing hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history) , mild to moderate hypercalciuria; in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases due to the rimantadine included in the drug).

If you have the diseases or conditions listed above, the patient should consult a doctor before taking the drug.

Pregnancy

The drug Antigrippin Maximum is contraindicated for use during pregnancy and lactation (breastfeeding).

Interaction with other drugs

If it is necessary to use Antigrippin-Maximum simultaneously with other drugs, the patient should consult a doctor.

Paracetamol

Reduces the effectiveness of uricosuric drugs.

Concomitant use of paracetamol in high doses enhances the effect of anticoagulant drugs.

When used simultaneously with metoclopramide, it is possible to increase the rate of absorption of paracetamol.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity of paracetamol.

Ascorbic acid

Increases the plasma concentration of benzylpenicillin.

Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron). May increase iron excretion when used concomitantly with deferoxamine.

Reduces the blood concentration of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

When used simultaneously, it reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) phenothiazine derivatives.

Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

Rimantadine

Enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Loratadine

Inhibitors of CYP3A4 and CYP2D6 increase plasma concentrations of loratadine.

Overdose

Symptoms of an overdose of the drug Antigrippin Maximum: in the first 24 hours, pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases are possible. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: administration of SH-group donors and precursors for the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

In case of overdose of the drug, the patient needs to consult a doctor.

Storage conditions

The drug Antigrippin Maximum should be stored out of the reach of children, in a dry place, protected from light at a temperature not exceeding 25°C. Shelf life - 2 years.

Release form

Capsules (two types): 20 pcs.

Compound

Two types of capsules.

Capsules P hard gelatin, blue, size No. 0; contents of capsules - a mixture of powder and/or granules of white or white with a creamy or pinkish tint, granules of irregular shape, different sizes, the presence of lumps is allowed.

1 capsule contains: paracetamol 360 mg.

Excipients: pregelatinized starch 9 mg, lactose monohydrate 4.2 mg, magnesium stearate 3.8 mg, colloidal silicon dioxide 3 mg.

Composition of the capsule shell: gelatin 94.795 mg, patented blue dye (E131) 0.265 mg, titanium dioxide (E171) 1.94 mg.

1 capsule contains: rimantadine hydrochloride 50 mg; ascorbic acid 300 mg; loratadine 3 mg; rutoside (in trihydrate form) 20 mg; calcium gluconate monohydrate 100 mg. Excipients: potato starch 2.2 mg, magnesium stearate 4.8 mg.

Composition of the capsule shell: gelatin 94.064 mg, yellow iron oxide dye (E172) 0.97 mg, red iron oxide dye (E172) 0.485 mg, crimson dye (Ponceau 4R) (E124) 0.511 mg, titanium dioxide (E171) 0.97 mg.

Additionally

Persons prone to drinking alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

The drug should not be used in the presence of metastatic tumors.

Antigrippin Maximum does not have carcinogenic properties.

Use in pediatrics

The drug in powder form should not be administered to children under 12 years of age.

The drug in capsule form is contraindicated in children and adolescents under the age of 18 years.

During the treatment period, patients should be careful when driving vehicles and other potentially dangerous activities that require high concentration and speed of psychomotor reactions.