How to take denol for the stomach. Side effects from De-Nol

Antibiotic De-Nol for stomach ulcers and gastritis is a drug used as a therapeutic and prophylactic not only during exacerbation, but also to maintain normal condition for chronic pathology. The product has astringent and bactericidal properties, since it is based on a bismuth preparation.

De-Nol is effective for the treatment of any inflammatory processes in the gastrointestinal tract and the rapid healing of erosions. The drug is especially active against bacteria Helicobacter pylori.

Composition and release forms

De-Nol is an antibiotic whose action is aimed at destroying pathogens.

The shell of the tablets has a rapidly dissolving structure, and the dragees themselves are slightly oblong oval shape. Produced by De-Nol in the Netherlands.

The active component of the antibiotic is calcium dicitrate. Renders protective properties– the affected areas not only heal faster, but are also covered with a special film that prevents the entry of bacteria. Tissues damaged by gastritis or ulcers return to normal much faster.

Use of De-Nol for stomach ulcers and gastritis

De-Nol is used to treat any type of gastritis, as it retains its activity not only in environments with normal acidity, but also in weakly acidic gastric juice (this often happens with this disease).

Tablets are prescribed not only for treatment acute ulcers or gastritis, but also to maintain normal functioning the body in those seasons when inflammatory processes in the stomach worsen and become active.

The action of De-Nol is based on the fact that it quickly dissolves in the stomach and penetrates into the deeper layers of the mucous membrane, preventing the activity of pathogenic bacteria that cause gastritis.

De-Nol is also effective in the treatment of ulcers - it not only protects the affected surface from microorganisms, but also improves the formation of pepsin. At the same time, the tablets kill pathogenic bacteria and reduce the acidity of gastric juice to prevent further damage to the membranes.

Such conditions are ideal for the stomach to return to normal as quickly as possible - gastritis recedes, and ulcers heal. It is more effective to treat these diseases with De-Nol in combination with antibacterial agents– then restorative the process will go even faster. The drug has a cumulative effect - the bismuth compound accumulates in the cell pathogenic bacteria, which entails irreversible gradual changes in its structure.

How De-Nol works

The product performs several functions at once that help quickly cure gastritis or ulcers:

enveloping the walls of the gastrointestinal tract with a protective film;
stimulation of mucus production;
relief of inflammation;
acceleration of regenerative processes;
healing of open wounds;
binding of bile acids;
restoration of normal flora in the stomach;
normalization of digestive processes;
slowing down the growth of pathogenic microbes;
elimination of irritation and too high acidity of the environment.

Note. De-Nol also has an astringent effect. You should consult your doctor about its use for ulcers or gastritis, since the tanning effect of the tablets is quite strong.

Standard doses of De-Nol

The dosages allowed for a single dose are precisely determined for this medicine. Children are allowed to drink De-Nol. The number of tablets that a patient can take without harm to health is determined based on the type of pathology and the patient’s health condition. The specific age of the person is also important:

from 4 to 8 years old take 1 dose of De-Nol, which is divided into 2 doses (8 mg of the drug per kilogram of weight);
from 8 to 14 years – 2 tablets per day for gastritis;
over 14 years old – 4 De-Nol tablets per day.

Sometimes specialists select other medications for children under 14 years of age because they consider De-Nol to be too active.

The tablets are taken 30 minutes before meals; be sure to take the tablet with water. To avoid complications, immediately after the antibiotic it is better not to drink alcohol, milk, coffee or any fruit juices - the concentration of the drug may increase.

Indications for treatment with De-Nol

The main indications for the use of De-Nol are obvious - treatment of gastritis in acute or chronic form or stomach ulcer. Antibiotics also help with other abnormalities:

bacterial infections in the gastrointestinal tract;
inflammatory processes in the abdomen;
constipation;
increased gas formation;
heartburn;
erosion;
duodenal ulcers.

Each disease has its own antibiotic regimen.

Contraindications to the use of De-Nol

De-Nol is not a medicine that to a large extent absorbed into the blood and affects the functioning of other organs and systems. However, continuous use for more than 2 months is not advisable, as this may cause excessive amounts of bismuth compounds to appear in the body.

There are not many obvious contraindications to the use of De-Nol:

age up to 4 years;
hypersensitivity to the components of the drug;
renal failure in a decompensated course.

During the period of bearing a child or while breastfeeding, it is preferable to refuse treatment of gastritis or ulcers with De-Nol or drink with caution and reduce its use to a minimum. It is better to choose the right diet for prevention or medicinal products, which consist of antacids and ready-made digestive enzymes.

Note. You should not prescribe De-Nol for gastritis yourself, as it misuse may cause the appearance malignant neoplasms in the stomach.

Side effects from De-Nol

Undesirable effects rarely occur:

Most often, the reaction manifests itself in the form of allergies, rashes or hives.
In some cases, De-Nol develops anaphylactic shock– this condition requires immediate medical care, as it is life-threatening.
At the very beginning of treatment, it is possible that the patient will feel nausea or even vomiting, constipation or diarrhea. This symptomatology is eliminated by other medications. The question of whether the patient should continue treatment for gastritis or ulcers with De-Nol is decided by the attending physician.
Due to the bismuth content in this medicine for gastritis, a person may notice that his tongue has become darker. Sometimes the stool turns black. This is considered the norm after the withdrawal of De-Nol, therefore complementary therapy does not require.
If treatment is carried out in large dosages, it may occur local violation kidney function, which disappears after stopping taking the pills.

This antibiotic for gastritis and ulcers has no effect on the ability to drive vehicles or work with precision mechanisms.

Overdose

If too much De-Nol is taken, the first step is to perform gastric lavage and induce vomiting. Salt laxatives and activated carbon help against poisoning with bismuth compounds.

After this, treatment is carried out, which is aimed at eliminating accompanying symptoms overdose with De-Nol. If the concentration of bismuth in the blood is elevated, the specialist may prescribe hemodialysis and other methods complex therapy, which are needed in a particular case. At least for the entire time the overdose is eliminated, De-Nol is canceled.

Analogues of the drug De-Nol

These pills for gastritis and stomach ulcers have many analogues. They include the same or similar active substance. The main difference is their price and manufacturer. The following analogues of De-Nol are often prescribed:

Vikalin;
Bismuth tripotassium dicitrate;
Gastrotipin;
Vis-nol;
Gastronorm;
Ampylop;
Sucralfate;
Venter;
Ventrisol;
Vikair;
Novobismol;
Kanalgat;
Gaviscon;
Gastrocepin;
Gaviscon forte.

The price of antibiotics depends on the country in which they were produced. All drugs cannot completely replace De-Nol, since their effects are different.

Note. Whether it is possible to use a specific remedy from the list for gastritis or ulcers must be clarified for each case separately.

Drug interactions

You cannot combine an antibiotic with any drugs in which bismuth is the active substance (for example, Vikaira, Pisala, Vikulina). An overdose of metal can cause the development of renal failure or encephalopathy.

The drugs Almagel and Maalox reduce the pharmacological activity of the antibiotic in the treatment of gastritis. This is stated in the instructions for use.

Combined use of De-Nol and Omez

To reduce the content of hydrogen chloride in gastric juice, De-Nol for gastritis and ulcers should be combined with proton pump blockers. Among the drugs that stop the secretion of hydrochloric acid, Omez (or Omeprazole) copes best with this. When De-Nol and Omez are used simultaneously, their properties are mutually enhanced. Improves and antimicrobial effect, which is important when carrying out therapy against ulcers and gastritis.

The exact drug treatment regimen must be selected based on clinical picture. Omez is capable of producing a long-lasting therapeutic effect, so it is drunk less frequently for gastritis with high acidity than De-Nol. In combination, the products well protect the affected mucosa from acid from gastric juice and pathogenic bacteria.

Both products are available by prescription only, so self-appointment Treatment for gastritis or ulcers is unacceptable. If you drink Omez or De-Nol uncontrollably, you can mask the signs of cancer - high acidity in the stomach is an indicator in this case.

De Nol is an antibiotic widely used to treat stomach ulcers and other inflammatory processes. It helps to quickly restore the affected tissue and protect it from further destruction. Omez and De-Nol are often drunk together - this is how these products give good healing effect. It is important to strictly follow the dosage and all doctor’s instructions, as otherwise serious side effects, up to an overdose of bismuth and masking oncology.

De-nol tablets belong to effective drugs treatment of gastritis, gastric and duodenal ulcers. The drug is readily used in gastroenterology. In addition to peptic ulcer medicine has high efficiency for a number of other diseases of the stomach and intestines. For the pathology of gastritis, De-nol is used with good results.

The main effects of the active substance of the drug are anti-inflammatory, enveloping and astringent. The effect of the drug leads to rapid recovery structure and normalization of the functions of cells of the mucous membrane of the stomach and duodenum.

By chemical composition the drug denol is a derivative citric acid, more precisely, its bismuth salt. The element bismuth has a pronounced therapeutic effect for gastritis and ulcerative lesions.

The drug is available in tablet form and is intended for oral administration only. The package includes instructions on how to take De-nol for gastritis.

Mechanism of therapeutic effect

The effect of De-nol is most pronounced in the treatment of peptic ulcers. When the drug enters the stomach, it forms a dense protective film on the walls, protecting damaged areas of the epithelium from the aggressive effects of hydrochloric acid and other factors, and can increase the rate of healing of ulcerative and erosive areas.

De-nol is recognized as an important quality in the treatment of gastritis and ulcers antibacterial effect in relation to the causative agent of ulcers and gastritis - the microorganism Helicobacter pylori. In the 20th century, scientists proved that the mentioned microorganism often causes the development of pathology of the digestive tract.

Gastritis of the stomach

Main indications and contraindications

The effectiveness and high digestibility of the drug has been proven for the following diseases:

Stomach ulcer.
Duodenal ulcer.
Dyspeptic syndrome.
Irritable bowel syndrome.
Chronic gastritis type B.
Ellison-Zollinger syndrome.

When prescribing De-nol for gastritis, you need to remember the contraindications that the drug has. It is not recommended to be treated with denol in patients suffering from acute or chronic renal failure, especially in severe. A relative contraindication is considered hypersensitivity or individual intolerance to the drug or individual biochemical components. De-nol is not prescribed for gastritis with low acidity.

An absolute contraindication to taking de-nol will be the period of gestation and breastfeeding. The drug has a pronounced teratogenic effect. If gastritis or peptic ulcer worsens in a pregnant woman, she will have to choose safer drugs.

How to take the drug correctly

Only a doctor has the right to prescribe the drug. It is forbidden to try to drink it yourself without the advice of a doctor. De-Nol tablets are taken orally. Important given proper nutrition. The regimen is structured in fractions, it is recommended to exclude spicy, salty and fatty foods from the diet, coarse fiber. Avoid eating foods that are too hot or too cold.

Directions for use and dosage

According to the instructions for use, the treatment regimen is as follows:

For the treatment of children from 4 to 8 years of age, tablets are prescribed at the rate of 8 mg per 1 kg of the child’s body weight. Average therapeutic dosage must be divided into two doses during the day.
If the child's age is between 8 and 12 years, average dosage– 1 tablet twice a day.
If the child has reached the age of 12 years or an adult patient is being treated, the drug is prescribed at the rate of 1 tablet 3 or 4 times a day.
For gastritis with high acidity, you should take tablets 30 minutes before meals. De-Nol capsules are washed down with plenty of clean filtered or boiled water.
The full therapeutic course for gastritis is 5 – 8 weeks. The final decision on how long De-nol should be taken is made by the attending physician. In some cases, a course is prescribed to prevent relapse of the disease.
When the course of treatment with the drug is completed, it is not recommended to take medications containing bismuth for the next two months.

Alternative scheme treatment - take 2 tablets before breakfast or before dinner. It is strictly forbidden to chew the tablets. It is possible to drink only non-carbonated clean water. Do not take the medicine with tea, milk or coffee. The action will reduce the effectiveness of treatment.

Possible side effects

When taking De-nol, a number of side effects may develop. The frequency of manifestations does not exceed a fraction of a percent.

Nausea and vomiting.
Frequent loose stools.
Constipation.
Allergic reactions - skin rash, urticaria, itching.

Symptoms appear extremely rarely and are mild. Usually disappears extremely quickly and does not require discontinuation of the drug. Drug treatment De-nolom remains highly effective under such conditions.

From time to time, patients note that taking De-nol causes the stool to turn dark. Reduced memory and attention are rarely observed.

Overdose

If the drug is taken in excessive doses, kidney function may be impaired. In case of overdose, use of the drug should be stopped immediately. The patient is instructed to immediately and thoroughly rinse the stomach. Before the brigade arrives emergency care it is possible to take the sorbent internally. Activated carbon is often taken. It won't hurt to take a saline laxative. At severe poisoning With bismuth preparations, the patient is sometimes prescribed hemodialysis. An overdose of a drug can occur when taking the drug for a long time or taking excessively large doses.

After discontinuation of the drug and emergency assistance, symptomatic treatment may be required. You will need to do a blood test to check your bismuth levels. If the result is elevated, the doctor prescribes complex therapy aimed at eliminating the symptoms.

Interaction with other drugs

For the treatment of gastritis or peptic ulcers, De-nol is prescribed in combination with antibacterial drugs. Several treatment regimens have been developed, including antibiotics and bismuth preparations.

In addition, De-nol is prescribed in combination with the drug Omez. The dosage and regimen are prescribed individually.

Remember, you need to take other medications at least half an hour before taking de-nol.

Interaction with alcohol

Patients often have questions about the compatibility of a drug with alcohol. There are no instructions for use for the drug special instructions about the possibility joint reception drugs and alcohol. Be aware that bismuth easily forms toxic compounds with alcohol that have a detrimental effect on the liver. This leads to a ban on simultaneous use alcohol and bismuth preparations.

Storage conditions of the drug

The drug should be stored in a dry place away from direct sunlight. It is better to store tablets in a room where the temperature does not exceed 25 degrees. Otherwise, the medicine will lose its pharmacological qualities.

Storing the drug in the refrigerator is strictly not recommended due to the excessively low temperature and high level of air humidity inside. The optimal solution would be to store the medicine in a specially designed first aid kit, out of reach of small children.

Before starting treatment, pay attention to external condition tablets. Should not be noted mechanical damage and chips. If defects are found in capsules or tablets, it is better not to use them. If the tablets have a changed taste or smell, this becomes evidence incorrect conditions storage

The treatment regimen for Helicobacter pylori with De-Nol consists of several drugs that are selected depending on the sensitivity of the bacterium. Such treatment tactics become simply necessary in most unsuccessful cases of eradication therapy.

Helicobutker pylori is a very insidious pathogen that lives in the gastric mucosa. Infiltrating surface layer, the bacterium causes hypersecretion, leading to inflammation. In this case, a stomach ulcer develops very quickly. Chronic gastritis associated with this microorganism cannot be treated with conventional means.

The most dangerous thing that bacteria conceals is the ability to cause precancerous conditions. In addition, Helicobacter Pilari is able to penetrate into the deeper layers of the mucous membrane. This pathogen is resistant to many antibiotics and cannot be easily eliminated. This requires a special circuit, which often contains various groups antibacterial drugs, as well as bismuth-containing products.

Principles of the therapeutic approach

Successful eradication of this pathogen lies in a properly selected regimen. To do this, it often includes:

2 antibiotics. The most commonly used drugs are tetracycline and penicillin groups. Previously, the regimen included the antiprotozoal drug Metronidazole. However, the bacterium became very resistant to this substance, and it was excluded from eradication tactics. In most cases, Amoxicillin, Tetracycline and other antibacterial drugs are prescribed. The combination of the two is important antimicrobial agents. They are taken for at least 10 days.
Proton pump blocker. Such tools can eliminate increased acidity gastric juice. In this case, the secretion of the digestive glands is blocked. Under such conditions, antibiotics are more effective. In addition, ulcerative lesions heal faster and the mucous membrane of the gastrointestinal tract is restored. The most commonly prescribed are Nolpaza, Omez and Emanera.
Bismuth-containing drug. De-Nol is unique in its action. Its active ingredient, bismuth tripotassium dicitrate, affects Helicobacter Pylori, preventing it from reproducing. In combination with antimicrobials and a proton pump blocker, such a medication leaves no chance for the pathogen. De-Nol also enhances regeneration processes in the mucous membrane and forms a protective barrier on the walls of the stomach. In this case, the ulcers heal in the shortest possible time.

Additional options

It is very effective to treat many dyspeptic disorders with the use of antibiotics and De-Nol. However, such therapy often causes side effects such as nausea, abdominal pain and diarrhea. In this case, the attending physician can add any probiotic or prebiotic to the regimen: Linex, Hilak Forte and others.

Such products help maintain normal microflora intestines, reducing the risk of side effects to zero. Often produce additional treatment propolis. As it turned out, this product beekeeping is detrimental to the bacteria that live in the stomach. No wonder propolis is called a natural antibiotic. In this case, a water tincture is used, which will have to be taken for at least a month.

Of course, the use of propolis is not the main method of therapy. It can be used as auxiliary treatment, which will bring enormous benefits and will stimulate regeneration processes in the gastric mucosa.

How to drink De Nol, how effective is it? This question interests those who suffer from stomach diseases.

There are many factors that negatively affect human health. Because of poor nutrition, frequent stress, lack of sleep, a person begins to feel pain in the stomach. In this case, De Nol tablets will help cope with the discomfort.

Composition and pharmacokinetics

De Nol is a new generation antibiotic that destroys pathogenic microbes. Available in the form of oval tablets coated with a quick-dissolving coating. The main producer is the Netherlands. The protective properties of this medicine, which contains bismuth tripotassium dicitrate, have proven themselves well. The mechanism of action of the drug is as follows: the tablet enters the stomach and the sore spots are covered with a thin film and heal quickly.

As a result, the stomach tissues receive protection from the acidic environment, enzymes produced as a result of digestion, and bacteria (they cause the progression of gastritis and ulcers). The active substance is completely excreted from the body along with feces and slightly through the kidneys (if bismuth is in the blood plasma).

De Nol is included in the complex treatment regimen. It is prescribed to those patients whose functions are impaired gastrointestinal tract, for gastric and duodenal ulcers, gastritis, dyspepsia, irritable bowel syndrome. You can drink de-nol for those who want to get rid of heartburn when low acidity stomach, cholecystitis, colitis, and other ailments.

Any illness requires proper treatment, depending on this, the course of treatment and dosage of the drug are determined.

Use for stomach diseases

When a person suffers from a stomach ulcer, the Helicobacter bacterium causes suffering. These harmful microorganisms help increase the acidity of gastric juice. While in the body, they may not manifest themselves in any way for quite a long time. Until the moment the immune system will not fail, which can be caused by:

past illness;
antibiotic;
avitaminosis;
stressful conditions;
bad habits (alcohol, smoking);
unbalanced diet;
hereditary factors.

Symptoms of stomach ulcer:

constantly tested painful sensations(may intensify in autumn and spring);
vomiting with a sour taste;
heartburn.

With an ulcer, pain usually occurs during or after eating. In a hungry state, the stomach calms down. To get rid of discomfort, drink a glass of milk or eat light porridge. To reduce acidity drink baking soda, which relieves pain in case of ulcers. You can significantly improve your condition if you take De Nol, after consulting with your doctor.

The formation of duodenal ulcers also occurs from exposure to Helicobacter bacteria. The risk group includes:

those who have someone in their family who suffered from this disease;
drink a lot of coffee;
heavy smokers;
alcoholics;
those who eat poorly;
often experiencing nervous overstrain;
patients with gastritis.

Symptoms of the disease:

stabbing or cutting pain;
nausea, sometimes with vomiting;
bloating or constipation;
loss of appetite.

The doctor will refer you for examination. And if it turns out that the cause of the ulcer is Helicobacter bacteria, then De Nol will help solve the problem.

De Nol helps a lot with gastritis. With this disease, the mucous membrane of the stomach becomes inflamed, resulting in an imbalance in its functioning and the digestibility of food is disrupted. As a result, a person loses weight and is deprived of the energy necessary for a full life.

Causes of the disease:

preference for spicy food;
passion for alcoholic drinks;
nervous tension;
lack of diet.

Gastritis makes itself felt by pain when a person goes without food for a long time. Sometimes abdominal pain begins to bother you even after eating. The disease may be accompanied by nausea, vomiting, and intestinal disorders.

Symptoms of acute gastritis:

strong pain;
nausea after eating;
heartburn;
vomiting with mucus;
excessive salivation;
diarrhea or constipation;
chills and high temperature;
cardiopalmus;
increased sweating and weakness.

In this case, you should definitely see a doctor, who will determine how to take de-nol for gastritis and prescribe a course of treatment.

Required dosage

When and in what doses to take De Nol is determined by a gastroenterologist. According to the instructions that come with the drug, usually adults and children over 14 years old take De Nol tablets 2 times, 2 pieces each. or 4 times 1 pc.

De Nol should be taken half an hour before meals. Eating 3 times a day, the patient drinks 3 tablets before meals before eating, and drinks 1 tablet at night. Another option is to take 2 tablets before breakfast and before dinner. The tablet should not be chewed, it should be swallowed with still water. Milk, coffee, tea are not suitable for this, as there is a risk negative influence on the effectiveness of the drug.

The duration of treatment depends on the severity of the disease. The course of treatment usually lasts no more than 2 months; after this period, the drug does not need to be taken.

After taking the drug, it is better to stop using other drugs containing bismuth for 2 months.

Overdose is possible if the drug was taken in large doses or for a long time. In this case, kidney function is impaired. To get rid of the identified symptoms, it is enough to stop the drug.

First aid for overdose - gastric lavage, taking activated carbon and saline laxatives.

In the future, symptomatic therapy will be needed. If the examination shows high level bismuth in the blood, then the doctor will prescribe a comprehensive treatment. With a pronounced character, they resort to hemodialysis. Any manifestation of overdose symptoms is a signal to discontinue the drug.

Interaction of De Nol with other medications cannot be ruled out. Half an hour before taking the drug and half an hour after taking it, other drugs are not useful. This rule also applies to reception food products and drinking. It is recommended not to drink milk, juices, or eat fruits at this time. This will help avoid imbalance in the gastrointestinal tract.

If you treat the stomach, they will not be useful sour dishes. Junk food will negate the beneficial effect of the medicine. Therefore, before taking De Nol, it is wise to discuss with your doctor what medications and foods can be consumed during treatment. After all, any excellent medicine, if taken incorrectly, will not give positive result, and can even harm the body.

Contraindications and side effects of the drug

Before you start taking De-nol for gastritis and other ailments, you need to find out who this drug is not suitable for.

You should be wary if the following factors are present:

individual intolerance to the drug;
renal dysfunction;
During pregnancy and breastfeeding.

Failure to comply with the instructions for taking the drug may lead to serious problems with health, and in case of pregnancy there is a threat to normal functioning internal organs future baby. You should not decide how to take your pills on your own. Only a specialist can determine the dosage, taking into account individual characteristics sick. It will also be necessary to find out whether there will be problems with the absorption of the medicine by the body.

Side effects may manifest as an allergic reaction and disorder digestive system.

An allergy is indicated by a rash on the skin and itching. In this case, you need to see a doctor, who will decide to change the dosage downward or suggest a different antibiotic. Unpleasant symptoms after taking the medication are possible - nausea, vomiting, frequent stool or constipation. These negative effects will soon pass. If this does not happen, then the medicine is not suitable and you should stop using it. With prolonged uncontrolled use of the drug, destruction develops nerve cells, which leads to encephalopathy. The reason is the accumulation of bismuth compounds in the tissues of the nervous system.

Storage rules

Only a dry place, out of direct sunlight, is suitable for storing the drug; the room temperature should not exceed 25°C, otherwise the medicine may soon become unusable.

It is worth considering that storing it in a refrigerator or in a damp room can affect the loss of properties of the drug. It is best to keep De Nol in a special first aid kit, which will be kept out of the reach of children.

You also need to pay attention to appearance tablets. There should be no mechanical damage or punctures, otherwise it is better not to use such medicine. A change in color and odor may also indicate non-compliance with storage conditions, so such tablets are also not suitable for oral administration. In general, De Nol does not require special storage conditions. It is important to endure temperature regime.

Please note that the shelf life of the tablets is 48 months.

De Nol is the most effective medicine in the treatment of stomach ulcers and helps cope with chronic gastritis. Important condition- complex treatment. Before taking the drug, be sure to consult a gastroenterologist and under no circumstances self-medicate.

Pathology of the digestive tract is one of the most common problems among humanity. Mostly middle-aged people suffer from gastritis and peptic ulcers. Pathologies are caused by various factors of aggression. They act externally and internally, and when the body’s defenses decrease, an inflammatory process occurs. There is a special scheme for the treatment of this condition, and it can be selected for each individual. Typically, several drugs are combined. You need to know how to take “Phosphalugel” and “De-nol” together, since they are considered the main ones in the fight against the disease.

These drugs are taken separately or in combination, which enhances the therapeutic effect. Before understanding their work, it is necessary to understand how they act each on their own and in complex. How to take “Phosphalugel” and “De-nol” together can be found in the leaflet attached to the drugs.

Indications for prescribing the drug "De-nol"

There are a certain number of indications for prescribing the drug for damage to the digestive tract. These include:

ulcers of the stomach and intestinal mucosa;
gastritis in exacerbation with varying acidity;
heartburn;
dyspeptic condition;
dyspepsia not associated with ulcers;
reflux gastritis;
functional lesions of the digestive tract.

The course of treatment is individual for each patient. It is allowed to combine De-Nol and Phosphalugel (the drugs and regimen are determined depending on the indications and the degree of damage to the digestive tract).

The use of the drug "De-nol" separately from other drugs

The drug is classified as an astringent medicine. Bismuth subcitrate forms the basis for the treatment of diseases of the digestive tract. "De-nol" creates a protective film against hydrochloric acid and other aggressive factors. It is produced in tablets that are taken orally. In cases of exacerbation of gastritis and ulcers, the product exhibits a high level of effectiveness. "De-nol" is used to treat irritable bowel syndrome. Patients with a functional dyspeptic condition take a drug that shows good results against the disease.

Yersinia;
rotoviruses;
clostridia;
E. coli;
Shigella

The drug creates a certain barrier not only against bacteria, but also protection against the penetration of toxic substances. They can enter the body from the outside in the form medicines(cytostatic substances and non-steroidal anti-inflammatory drugs), alcoholic beverages.

Rules for taking the drug "De-nol"

People over 12 years of age can take the medication no more than 4 times a day, 1 tablet. You need to drink it only with water. The drug is taken 30 minutes before meals and before bedtime. In exceptional cases related to the patient’s condition, the gastroenterologist prescribes 2 tablets of the drug “De-nol” at a time. Children are prescribed an individual dosage.

Indications for prescribing the drug "Phosphalugel"

The range of indications for the use of the drug is very similar to when it is necessary to use De-nol. Therefore, they can be combined in a scheme for such pathologies as:

peptic ulcer;
diaphragmatic hernia;
dyspepsia of various origins;
reflux esophagitis;
diarrhea not related to ulcerative disease of the digestive tract.

Before starting treatment, you need to read the instructions to know how to take De-nol with Phosphalugel. The dosage and frequency of administration are determined depending on the indications and severity of the patient’s condition.

Using the drug "Phosphalugel" separately from other drugs

The drug is available in the form of a gel. Main active ingredients in the fight against the inflammatory process of the digestive tract are:

agar-agar;
aluminum phosphate;
sorbitol;
pectin.

Thanks to its adsorbing and enveloping properties, the drug protects the mucous membrane from the aggressive effects of hydrochloric acid. Chronic gastritis "De-nol", "Phosphalugel" is treated according to a certain scheme depending on the age and severity of the condition.

The drug has the property of reducing the effect of pepsin and binding bile acids. "Phosphalugel" is highly effective for irritable bowel syndrome and functional dyspepsia. The adsorbing properties of the drug allow you to get rid of harmful microorganisms, causing fermentation processes in the digestive tract. Toxic substances entering the body are quickly neutralized by the main components, which protects the sensitive mucous membrane from the effects of aggressive factors.

The drug should be taken in pure form or diluted with water at room temperature. Adults and children are advised to take several sachets of the drug during the day, depending on the severity of the condition.

In case of ulcerative lesions of the mucous membrane of the stomach and intestines, a sachet of medicine must be taken an hour after meals. For functional disorders of the gastrointestinal tract, Phosphalugel is taken in the morning, afternoon and evening.

Rules for taking medications

If there are diseases of the digestive system and there are indications, the gastroenterologist will tell you how to take Phosphalugel and De-Nol together. They should be taken separately from other drugs included in the treatment regimen. The products “De-Nol” and “Phosphalugel” have good compatibility, and therefore they can be taken several hours apart. The first is usually prescribed half an hour before meals, and the second should be drunk after meals, but after 1.5-2 hours. They interact at such a level that they do not reduce or enhance effectiveness in each other's presence.

Side effects

Medicines have wide range indications for pathology of the gastrointestinal tract in the acute phase. Like any other drug, they can cause side effects. These include:

allergic reaction due to intolerance to certain components;
“Phosphalugel” can provoke constipation, and “De-nol” can cause diarrhea;
nausea or vomiting.

Due to the listed conditions, you cannot take the medication yourself. It is first necessary to consult a specialist and collect the necessary information that will prevent the development of the listed conditions. To avoid the development of complications, you should first read the instructions, which indicate how to take “Phosphalugel” and “Omeprazole” for gastritis, ulcers and other pathologies.

Contraindications to the use of drugs

There are certain conditions when it is temporarily or not at all recommended to be treated with the medications “De-Nol” and “Phosphalugel”, both in monotherapy and in combination. These include the following conditions:

chronic renal failure, occurring in severe severity;
intolerance to certain substances that form the basis of the drug or are among the additional ones;
diabetes.

The listed conditions are not always an absolute limitation for taking medications. To clarify this issue, consultation with a specialist is necessary.

De-Nol belongs to the group of gastroprotector drugs, drugs for the gastrointestinal tract with antiseptic and astringent action. Antibacterial activity complemented by antiulcer and anti-inflammatory effects in the gastric cavity. Indications for use of De-Nol, dosage, frequency of administration and duration of courses of therapy are determined by the attending physician according to the instructions for use.

For what diseases is De-Nol prescribed?

The use of De-Nol is justified when the following diseases And pathological processes organs of the gastrointestinal tract:

peptic ulcer of the stomach, duodenum with various stages of damage to the internal walls of organs during exacerbations of diseases;
acute and chronic stages of gastritis, gastroduodenitis, including Helicobacter pylori-associated forms of diseases;
with irritable bowel syndrome, accompanied by diarrhea as a symptom of the disease;
with functional dyspepsia without organic etiology;
at peptic ulcer stomach and duodenum;
damage to the gastric mucosa caused by taking NSAIDs (non-steroidal anti-inflammatory drugs, including acetylsalicylic acid, ibuprofen, etc.).

Dosage form and packaging of De-Nol

De-Nol is produced in dosage form in the form of round, biconvex, light cream, film-coated tablets. To protect against counterfeiting, each tablet has a graphic double-sided embossing “gbr 152” and a graphic design: a square with smoothed corners and breaks in the lines of the sides. A slight odor of ammonia is acceptable.
De-Nol tablets are packed in blisters of 8 pcs. There are 7 or 14 blisters in a cardboard package of the drug.

Composition of the drug

The active ingredient De-Nol is a bismuth preparation: each tablet contains 304.6 mg of tripotassium bismuth decitrate, which corresponds to 120 mg of bismuth oxide. Among the auxiliary forming substances are corn starch, magnesium stearate, potassium polyacrylate, hypromellose and others in small quantities.

Contraindications for taking De-Nol

De-Nol is not prescribed for certain diseases, pathologies (with severe renal impairment of various etiologies), allergic reaction and individual intolerance components of the drug, as well as physiological conditions, which are not diseases (pregnancy, lactation) due to the likely effect on the fetus and the possibility of penetration of the active substance into breast milk. Considering the effects of bismuth as a salt heavy metal on the central nervous system, if there is a need to take De-Nol during lactation for the period of therapy breast-feeding needs to stop.

Do not prescribe De-Nol if there are other medications containing bismuth in the current or recent course of therapy or other diseases. Contraindication to therapy with this medication is childhood (under 14 years). IN in rare cases Possible use from 4 years of age according to a special scheme with individual calculation of the daily dose of the drug. Typically, De-Nol's early age used as an element of complex treatment for anti-Helicobacter therapy according to the “classical triple” scheme in combination with two antibiotics.

De-Nol: possible side effects

Among the most common side effects of taking the drug De-Nol are reactions from the digestive system and gastrointestinal tract: nausea, dyspeptic symptoms (constipation, flatulence, increased bowel movements, less often diarrhea), decreased appetite, metallic taste in the mouth, vomiting. It is also possible that the tongue may darken or change color feces to dark brown, black. These effects, as a rule, accompany the period of adaptation of the body to the drug, go away on their own and do not require interruption of the course of treatment.

Allergic reactions in the vast majority of reported cases are expressed by itching and rashes (“urticaria”) on the skin. The decision on the advisability of continuing therapy or stopping it is made by the attending physician. In extremely rare cases, anaphylactic shock has been reported as a reaction to De-Nol.
Long-term treatment with high dosages is dangerous due to the development of the following conditions: nephropathy, gingivitis, arthralgia, pseudomembranous colitis, as well as encephalopathy due to the ability of bismuth preparations to accumulate in the central nervous system. Such courses are conducted only by appointment and under the supervision of a specialist. According to the instructions for use, De-Nol is used continuously for no more than 2 months with any treatment regimen precisely because of the effect of accumulation in the tissues of the central nervous system.
All side effects that accompany taking the drug, if prescribed, occur with a fairly low frequency and go away on their own when the course of treatment is stopped.

Consequences of a drug overdose

With long-term use, which has caused the accumulation of bismuth in the tissues of the central nervous system, the course of treatment is canceled. Symptomatic therapy is indicated. At acute poisoning, caused by taking a dose 10 or more times higher than the average for an adult, symptoms manifest themselves in impaired filtration function of the kidneys (renal failure).

Diagnosis is made based on medical history, laboratory analysis blood shows an excess of reference values for the amount of bismuth in the blood.
Therapy for acute poisoning is nonspecific; there is no antidote to bismuth preparations. Gastric lavage, saline laxatives, adsorbents, supportive treatment to restore renal function, and in severe cases, hemodialysis are indicated.

De-Nol: compatibility with other medicines and food products

De-Nol is taken separately from food, liquid and other medications, especially those with antacid action. Recommended temporary pauses: 30 minutes before and 30 minutes after taking the drug.

De-Nol should not be taken with milk, liquid dairy products, fruit, vegetable juices etc. due to the effect on the effectiveness of the drug. Take the tablets with still water.

The general course of therapy should not contain other medications with bismuth preparations due to the high total bismuth content, which can significantly increase the risk of side effects from both the gastrointestinal tract and the central nervous system.

De-Nol: how to use the medicine correctly?

De-Nol is prescribed as part of complex therapy for diseases of the digestive tract in adults and children over 14 years of age. The duration of the course of treatment, dosage, and frequency of administration are determined by a specialist based on the medical history, diagnosis, stage of the disease and the individual characteristics of the patient for each specific case.
The average daily dose of De-Nol is 4 tablets per day. Depending on the prescription of the attending physician, the dose is divided into 2 or 4 doses with conditionally equal time intervals.
In the standard treatment regimen with three meals a day, it is recommended to take 1 dose of the drug (1 tablet) half an hour before breakfast, lunch and dinner, and the last dose at night. An alternative treatment regimen, preferable for some diseases and pathologies, is based on taking 2 tablets twice before breakfast and dinner, observing a 12-hour time interval.
De-Nol is taken orally by swallowing the tablet whole. Grinding, breaking, chewing dosage form not acceptable. When receiving, it is necessary to ensure simultaneous admission sufficient quantity liquids into the stomach, preferably - clean water. The simultaneous intake of milk, fruit, vegetable juices and nectars is strictly prohibited.
The duration of therapy depends on the diagnosis, stage of the disease and the therapeutic effect of the drug for a given patient. The course of treatment can be 30-60 days continuously, but not longer than 2 months.
Upon completion of treatment, it must be remembered that the next course of therapy, including De-Nol or other bismuth-containing drugs, can be started no earlier than 2 months after the previous one due to the risk of increased accumulation of bismuth in the tissues of the central nervous system.

De-Nol: conditions for dispensing in pharmacies and storage rules

De-Nol is an over-the-counter medicine and is freely sold in pharmacies. The rules for storing the drug include temperature environment(room temperature, close to 20° C with minor fluctuations), lack of high humidity and exposure to direct sunlight. Subject to these storage conditions and the integrity of the packaging, the guaranteed shelf life of the De-Nol drug is 4 years.

Among huge amount drugs that are presented on Russian market, it is difficult to find products that do not cause side effects. Despite the achievements modern pharmaceuticals, almost all medications, even when taken correctly and in compliance with the dosage, can cause some harm to the patient’s body. However, it is impossible to do without medications at all, because for a number of diseases it is necessary to carry out therapy as quickly as possible.

The list of such problems is quite wide, and diseases of the stomach and duodenum occupy not the least place in it. When such diagnoses are made, the doctor usually prescribes a course of treatment with De-Nol. This drug is considered one of the most effective and safe. Of course, this statement is true only if all medical recommendations, issued simultaneously with the appointment. However, most patients still have many questions regarding this drug. How many days does the course of treatment with De-Nol last for stomach ulcers? How to take pills correctly? How often to repeat the De-Nola course? Is it normal to have side effects during treatment? What optimal course"De-Nola" for gastritis?

Judging by the questions above, most often patients try to find out details about the duration of treatment. This is exactly the topic we will touch on in the article. Readers will draw from it all the information they are interested in about the course of treatment with De-Nol. We will also briefly describe the drug itself and note all the features of its administration.

General characteristics of the medicine

As soon as the doctor diagnoses the patient with an “ulcer” or “gastritis” after treatment, he will most likely immediately prescribe him a course of treatment with De-Nol. The doctor usually tells you how many tablets to take and how to do it right there in the office, but he does not give a description of the medicine. Although this information is very useful for patients.

So, first of all, you should understand that this drug is one of the most powerful. In addition, it allows you to take a comprehensive approach to the problem, and this already makes it possible to prescribe a simplified regimen and course of treatment. Many patients confuse “De-Nol” and “Omez” with each other, considering them equivalent drugs and replacing them according to at will. However, this cannot be done, since the product we are describing is unique in many respects.

We will tell you how many days the course of treatment with De-Nol lasts for gastritis and ulcers a little later. Now let’s find out what kind of drug this is. The medicine has both healing and antiseptic properties, which makes it indispensable in the treatment of diseases of the gastrointestinal tract. It also has astringent properties that help the drug cope with diseases more effectively. In addition, the course of treatment with De-Nol relieves the patient of Helicobacter pylori, which is the culprit of peptic ulcer disease. A huge advantage of the medicine is the fact that it is not an antibiotic. And therefore, it will not cause serious side effects characteristic of this group of drugs.

I would also like to mention that even with a long course of taking De-Nol, Helicobacter pylori cannot develop resistance to the drug. The medication is equally effective in primary and re-treatment. Such characteristics are rarely combined in one medicine.

Release form of the drug

Before starting a course of treatment with De-Nol for gastritis or peptic ulcers, you need to protect yourself from counterfeits. To do this, you need to study what the tablets should look like.

The manufacturer produces the drug only in tablet form. They have a biconvex shape and are covered with a film shell. Usually the color of the tablets is close to light cream, but minor deviations towards darker or lighter shades are allowed.

The pills are very well protected from counterfeiting due to embossing. It is applied on both sides and consists of an inscription and a graphic design. Some patients undergoing treatment with De-Nol complained of bad smell emanating from the tablets. Pharmacists note that this is the norm. Original tablets may emit a mild ammonia odor.

The manufacturer packages the drug in cardboard boxes. Each contains several blisters. They contain eight tablets. On average, a pack contains from seven to fourteen blisters. Maximum amount tablets per package - one hundred and twelve.

Depending on the severity and nature of the disease, the doctor may prescribe both a minimum course of treatment with De-Nol and a maximum course with a possible repetition in a few months. Based on this, the patient has the opportunity to calculate in advance which package of tablets he will need.

Composition of the drug and dosage

Often patients with peptic ulcer and gastritis they are trying to independently compare “De-Nol” and “Omez” with each other. Treatment regimens and courses of administration of these medications, however, vary greatly. And this is not surprising, because despite the fact that the drugs have similar indications for use, they contain different active ingredients.

"De-Nol" consists of active and additional substances. The first category includes bismuth oxide. It is this substance that provides the broad therapeutic effect that the drug has. There are 120 milligrams in each tablet.

Auxiliary components are selected and included in the composition of the medicine in order to promote rapid absorption active substance in the gastrointestinal tract. This group of components includes:

corn starch;
povidone;
magnesium stearate;
potassium polyacrylate.

In addition, it is necessary to mention the components that make up the film coating of the tablets:

macrogol;
hypromellose.

All Excipients are present in the drug in small quantities.

Indications for taking tablets

In almost one hundred percent of cases, the doctor prescribes a course of treatment with De-Nol for stomach ulcers and gastritis. However, these are not the only indications for use. this drug. The list of health problems that tablets can effectively treat is quite extensive:

duodenal ulcer in different stages leakage;
gastroduodenitis;
irritable bowel syndrome (including diarrhea as one of the symptoms);
dyspepsia;
peptic ulcer of the stomach;
peptic ulcer of the duodenum;
lesions of the gastric mucosa.

Most often, the last of these problems occurs with long-term use of non-steroidal anti-inflammatory drugs.

Effect of the drug

The spectrum of action of the tablets is quite wide, which is why the course of treatment with De-Nol is so effective for peptic ulcers and gastritis. Even after initial appointment the drug forms a protective film that envelops internal walls stomach. At the same time, it very effectively neutralizes Helicobacter pylori.

At the same time, the drug helps normalize the acid-base balance, improve blood circulation in the stomach, and accelerate metabolic processes. It was also noticed that during the treatment the rate of regeneration of damaged tissue increases.

Doctors say that the already damaged gastric mucosa is actively destroyed by pepsin produced by the body. Its concentration decreases significantly after a course of treatment with De-Nol (and Omez, by the way, a similar effect can be achieved).

It should also be mentioned that the drug acts as a means to strengthen the immune system. It has been proven that a decrease in its activity creates all the conditions for Helicobacter pylori to penetrate the body. The more weakened the immune system, the more harmful bacteria penetrate. Initially, it manifests itself as symptoms of gastritis, then it becomes the cause of ulcers on the mucous membrane. And at this stage, this can already threaten the patient with cancer.

The mechanism of action of tablets on the causative agent of peptic ulcer disease

From our article, readers have already learned what De-Nol treats. A course of treatment with this drug successfully neutralizes Helicobacter pylori.

The mechanism of action of the drug on this harmful microorganism is quite simple. When taking the drug, the effect is directly on the cell walls of the bacterium. They begin to collapse, and as a result of this process, irreversible changes in the cytoplasm of a microorganism. After some time he dies.

It is noteworthy that the active substance of the drug is able to penetrate into the most deep tissue and restore them. The point of not becoming addicted to the pills, even with long-term use, is very important. Helicobacter bacteria cannot adapt to the components of the medicine, so it is effective even with a repeated course.

Contraindications

Do not forget that De-Nol is not suitable for all patients, despite its high effectiveness. Some health problems may prevent you from taking it. However, their list is limited to just a few points:

Taking other products containing bismuth. This substance tends to accumulate in the body, so there should be a break of at least three to four months between therapeutic courses.
Childhood. Usually, De-Nol is not prescribed to a child under fourteen years of age. But there are exceptions to this rule: in particularly difficult cases, the doctor may prescribe this medicine a child from four years old. This can be done as part of complex therapy together with two antibiotics. Moreover, the course of treatment with De-Nol (such situations are not specified in the instructions for use) should be minimal.
Pregnancy and breastfeeding. Women expecting a baby should avoid taking this drug. Its active substance has Negative influence on the fetus, as a result, the child may be born with serious pathologies. During lactation, De-Nol is also contraindicated. Its components very easily penetrate into breast milk and disrupt the functioning of the baby’s urinary and nervous systems. Result similar treatment mother can be very distressing for the baby.
An allergic reaction to bismuth is uncommon, but it can happen. Therefore, people prone to allergies should not drink De-Nol. Doctors do not prescribe it even if there is an individual intolerance to any components of the drug.
The drug is strictly contraindicated for kidney diseases of varying nature and severity.

The instructions for the tablets indicate that they should not be taken by people with problems associated with liver disease. In these cases, treatment can aggravate them and be accompanied by a number of side effects.

The drug "De-Nol". What course of treatment is considered optimal?

The attending physician prescribes the drug to persons suffering from diseases of the digestive tract. Moreover, they must definitely be over fourteen years old. Only the doctor can draw up the dosage regimen; doing this without permission is strictly contraindicated. The specialist takes into account all the nuances of the course of the disease: its stage, severity, age of the patient and similar points.

On average, no more than four tablets of the drug are prescribed per day. Moreover, they should be taken at regular intervals. Depending on the treatment regimen, the doctor may divide the daily dosage into two or four doses.

The standard course of treatment involves a regimen in which the patient takes one tablet four times a day. The first three doses take place before breakfast, lunch and dinner, and the last one at night. It is important to take the tablets thirty minutes before meals for absolutely empty stomach. This concept includes not only the absence of food in it, but also liquid.

An alternative course of treatment is prescribed for other diseases. In this case, it is recommended to take “De-Nol” two tablets twice a day - before breakfast and dinner. It is important to maintain an interval of twelve hours between doses of the medication.

The drug should be taken only with clean water. Juices, teas and other drinks, reacting with the components of the drug, interfere with the absorption of the drug and its mechanism of action.

It is worth keeping in mind that the tablets should not be chewed, broken, or taken in pieces.

The minimum course of therapy is one month, but doctors often advise stopping treatment if there are obvious improvements in the condition, accompanied by neutralization of unpleasant symptoms.

The longest course of De-Nol cannot be more than two months of continuous use. If during this period of time the condition has not stabilized, then the next time you can start taking the medicine only after a sixty-day interval

It should be taken into account that the patient cannot take other drugs containing bismuth. This substance has an accumulation effect in the central nervous system, which negatively affects its functioning.

Features of treatment

"De-Nol" is a fairly powerful drug, so when taking it you must follow some simple rules.

Patients should know that the drug is most effective when thirty minutes before the tablet enters the body and thirty minutes after that, no food or liquid enters the stomach. The fact is that a large amount of gastric juice is required to break down the tablets.

At vegetative-vascular dystonia it is necessary to complete the minimum course of taking De-Nol. If this recommendation is not followed, the patient's condition will worsen due to regular headaches and dizziness.

Keep in mind that bismuth, which is the active component of the drug, has the effect of turning stool black. Although this reaction is natural, it should definitely be reported to your doctor.

If in the first week of treatment you notice a general deterioration in your condition, then perhaps these are side effects of the drug, which means the course of treatment needs to be stopped.

A few words about side effects

If we analyze all possible negative reactions body to take pills, then most often they occur in the gastrointestinal tract. The main symptoms are nausea, vomiting, disruption of daily bowel movements (constipation, diarrhea, increased bowel movements, and so on). Flatulence is also possible, accompanying the patient throughout the day. In some cases, there is a decrease in appetite and a change in taste preferences. Sometimes during treatment there is a persistent metallic taste in the oral cavity. The color of the tongue in many patients changes to dark brown after the first days of taking the pills. All of these reactions are considered symptoms of the body’s adaptation to bismuth. They usually go away on their own in one to two weeks.

An allergy is a good reason to stop treatment. This effect manifested by skin itching, skin rashes and tissue swelling. Such symptoms should be reported to your doctor. After examining the patient, he must decide to cancel or change the treatment regimen.

A long course of treatment is possible only under the supervision of a doctor. It is prescribed in very rare cases, since the risk of side effects increases several times. In addition, many of them are hazardous to health. Such reactions include nephropathy, encephalopathy, gingivitis, and so on. Often long-term use“De-Nola” causes the development of colitis and arthralgia in patients.

Overdose. How to determine it

When you start taking De-Nol, it is important to understand that an overdose is extremely dangerous. It causes irreversible changes in the body. Among them, acute renal failure can be distinguished, which in parallel leads to high slagging and increased blood pressure.

The most dangerous are brain dysfunctions. Initially, the patient feels only weakness, then insomnia is added to it. If the drug is not stopped, treatment can be fatal.

Disorders of the gastrointestinal tract, which have become chronic, are also one of the results of an overdose of De-Nol.

It is worth keeping in mind that an overdose of the drug occurs at levels such as one hundred milligrams of bismuth per liter of blood. This can only be determined in a laboratory way.

Patients need to know that there is no antidote to bismuth. Therefore, as an emergency aid in case of overdose, doctors use gastric lavage and adsorbents. In particularly severe cases, urgent hemodialysis is required.

How to drink De Nol, how effective is it? This question interests those who suffer from stomach diseases.

There are many factors that negatively affect human health. Due to poor nutrition, frequent stress, and lack of sleep, a person begins to feel pain in the stomach. In this case, De Nol tablets will help cope with the discomfort.

Composition and pharmacokinetics

De Nol is included in the complex treatment regimen. It is prescribed to those patients who have impaired gastrointestinal tract functions, gastric and duodenal ulcers, gastritis, dyspepsia, irritable bowel syndrome. You can drink de-nol for those who want to get rid of heartburn with low stomach acidity, cholecystitis, colitis, and other ailments.

Any ailment requires proper treatment; depending on this, the course of treatment and dosage of the drug are determined.

Use for stomach diseases

When a person suffers from a stomach ulcer, the Helicobacter bacterium causes suffering. These harmful microorganisms increase the acidity of gastric juice. While in the body, they may not manifest themselves in any way for quite a long time. Until the immune system fails, which can be caused by:

past illness;
antibiotic;
avitaminosis;
stressful conditions;
bad habits (alcohol, smoking);
unbalanced diet;
hereditary factors.

Symptoms of stomach ulcer:

constantly experienced pain (may intensify in autumn and spring);
vomiting with a sour taste;
heartburn.

With an ulcer, pain usually occurs during or after eating. In a hungry state, the stomach calms down. To get rid of discomfort, drink a glass of milk or eat light porridge. To reduce acidity, drink baking soda, which relieves pain in case of ulcers. You can significantly improve your condition if you take De Nol, after consulting with your doctor.

The formation of duodenal ulcers also occurs from exposure to Helicobacter bacteria. The risk group includes:

those who have someone in their family who suffered from this disease;
drink a lot of coffee;
heavy smokers;
alcoholics;
those who eat poorly;
often experiencing nervous overstrain;
patients with gastritis.

Symptoms of the disease:

stabbing or cutting pain;
nausea, sometimes with vomiting;
bloating or constipation;
loss of appetite.

The doctor will refer you for examination. And if it turns out that the cause of the ulcer is Helicobacter bacteria, then De Nol will help solve the problem.

Causes of the disease:

preference for spicy food;
passion for alcoholic drinks;
nervous tension;
lack of diet.

Symptoms of acute gastritis:

strong pain;
nausea after eating;
heartburn;
vomiting with mucus;
excessive salivation;
diarrhea or constipation;
chills and high temperature;
cardiopalmus;
increased sweating and weakness.

In this case, you should definitely see a doctor, who will determine how to take de-nol for gastritis and prescribe a course of treatment.

Required dosage

De Nol should be taken half an hour before meals. Eating 3 times a day, the patient drinks 3 tablets before meals before eating, and drinks 1 tablet at night. Another option is to take 2 tablets before breakfast and before dinner. The tablet should not be chewed, it should be swallowed with still water. Milk, coffee, tea are not suitable for this, as there is a risk of a negative effect on the effectiveness of the drug.

The duration of treatment depends on the severity of the disease. The course of treatment usually lasts no more than 2 months; after this period, the drug does not need to be taken.

After taking the drug, it is better to stop using other drugs containing bismuth for 2 months.

An overdose is possible if the drug is taken in large doses or for a long time. In this case, kidney function is impaired. To get rid of the identified symptoms, it is enough to stop the drug.

First aid for overdose is gastric lavage, taking activated charcoal and saline laxatives.

In the future, symptomatic therapy will be needed. If the examination shows a high level of bismuth in the blood, the doctor will prescribe a comprehensive treatment. With a pronounced character, they resort to hemodialysis. Any manifestation of overdose symptoms is a signal to discontinue the drug.

Interaction of De Nol with other medications cannot be ruled out. Half an hour before taking the drug and half an hour after taking it, other drugs are not useful. This rule also applies to eating and drinking. It is recommended not to drink milk, juices, or eat fruits at this time. This will help avoid imbalance in the gastrointestinal tract.

If the stomach is treated, then sour dishes will not be beneficial. Junk food will negate the beneficial effect of the medicine. Therefore, before taking De Nol, it is wise to discuss with your doctor what medications and foods can be consumed during treatment. After all, any excellent medicine, if taken incorrectly, will not give a positive result, and can even harm the body.

Contraindications and side effects of the drug

Before you start taking De-nol for gastritis and other ailments, you need to find out who this drug is not suitable for.

You should be wary if the following factors are present:

individual intolerance to the drug;
renal dysfunction;
During pregnancy and breastfeeding.

Failure to follow the rules for taking the drug can lead to serious health problems, and in case of pregnancy, there is a threat to the normal functioning of the internal organs of the unborn baby. You should not decide how to take your pills on your own. Only a specialist can determine the dosage, taking into account the individual characteristics of the patient. It will also be necessary to find out whether there will be problems with the absorption of the medicine by the body.

Side effects can manifest themselves in the form of an allergic reaction and digestive system disorders.

An allergy is indicated by a rash on the skin and itching. In this case, you need to see a doctor, who will decide to change the dosage downward or suggest a different antibiotic. Unpleasant symptoms after taking the medication are possible - nausea, vomiting, frequent bowel movements or constipation. These negative effects will soon pass. If this does not happen, then the medicine is not suitable and you should stop using it. With prolonged uncontrolled use of the drug, destruction of nerve cells develops, which leads to encephalopathy. The reason is the accumulation of bismuth compounds in the tissues of the nervous system.

Storage rules

Only a dry place, out of direct sunlight, is suitable for storing the drug; the room temperature should not exceed 25°C, otherwise the medicine may soon become unusable.

You need to pay attention to the appearance of the tablets. There should be no mechanical damage or punctures, otherwise it is better not to use such medicine. A change in color and odor may also indicate non-compliance with storage conditions, so such tablets are also not suitable for oral administration. In general, De Nol does not require special storage conditions. It is important to maintain temperature conditions.

Please note that the shelf life of the tablets is 48 months.

De Nol is the most effective medicine in the treatment of stomach ulcers and helps cope with chronic gastritis. An important condition is comprehensive treatment. Before taking the drug, be sure to consult a gastroenterologist and under no circumstances self-medicate.

Indications for prescribing the drug "De-nol"

There are a certain number of indications for prescribing the drug for damage to the digestive tract. These include:

ulcers of the stomach and intestinal mucosa;
gastritis in exacerbation with varying acidity;
heartburn;
dyspeptic condition;
dyspepsia not associated with ulcers;
reflux gastritis;
functional lesions of the digestive tract.

The use of the drug "De-nol" separately from other drugs

Yersinia;
rotoviruses;
clostridia;
E. coli;
Shigella

The drug creates a certain barrier not only against bacteria, but also protection against the penetration of toxic substances. They can enter the body from the outside in the form of medications (cytostatic substances and non-steroidal anti-inflammatory drugs), alcoholic beverages.

Rules for taking the drug "De-nol"

Indications for prescribing the drug "Phosphalugel"

The range of indications for the use of the drug is very similar to when it is necessary to use De-nol. Therefore, they can be combined in a scheme for such pathologies as:

peptic ulcer;
diaphragmatic hernia;
dyspepsia of various origins;
reflux esophagitis;
diarrhea not related to ulcerative disease of the digestive tract.

Using the drug "Phosphalugel" separately from other drugs

The drug is available in the form of a gel. The main active ingredients in the fight against the inflammatory process of the digestive tract are:

agar-agar;
aluminum phosphate;
sorbitol;
pectin.

The drug has the property of reducing the effect of pepsin and binding bile acids. "Phosphalugel" is highly effective for irritable bowel syndrome and functional dyspepsia. The adsorbing properties of the drug allow you to get rid of harmful microorganisms that cause fermentation processes in the digestive tract. Toxic substances entering the body are quickly neutralized by the main components, which protects the sensitive mucous membrane from the effects of aggressive factors.

The drug should be taken pure or diluted with water at room temperature. Adults and children are advised to take several sachets of the drug during the day, depending on the severity of the condition.

Rules for taking medications

Side effects

Medicines have a wide range of indications for gastrointestinal pathology in the acute phase. Like any other drug, they can cause side effects. These include:

allergic reaction due to intolerance to certain components;
“Phosphalugel” can provoke constipation, and “De-nol” can cause diarrhea;
nausea or vomiting.

Contraindications to the use of drugs

chronic renal failure, occurring in severe severity;
intolerance to certain substances that form the basis of the drug or are among the additional ones;
diabetes.

The listed conditions are not always an absolute limitation for taking medications. To clarify this issue, consultation with a specialist is necessary.

biconvex, round shape tablets in film casing with the imprint “gbr 152” on one side and a graphic image in the form of a square with rounded corners and broken sides on the other. The color of the tablets is white with a cream tint, light smell ammonia (may be absent).

The tablets are packaged in blisters of 8 pieces. One cardboard package can contain 56 or 112 tablets.

pharmachologic effect

Bismuth preparation. Renders antibacterial , antiulcer And gastroprotective action.

In accordance with the information presented on Wikipedia, bismuth subcitrate is included in the “Pharmacological Index” group “ Antacids and adsorbents ”.

Pharmacodynamics and pharmacokinetics

Bismuthate tripotassium dicitrate is characterized by a multifaceted effect, due to which the drug De-Nol affects all levels of origin and development peptic ulcer .

The astringent effect is due to the ability bismuth subcitrate Precipitate proteins by forming chelate complexes with them. As a result, on the surface of the affected peptic ulcer areas mucous membrane of the stomach and duodenum a protective film is formed, which eliminates the possibility harmful effects the acidic environment of the stomach on the affected mucosa. This in turn contributes to faster scarring of the ulcers.

De-Nol shows bactericidal properties in a relationship Gram (-) bacteria Helicobacter pylori . This effect is based on the ability of the active substance of the drug to suppress enzymatic activity in the microbial cell, disrupt the microstructure and permeability of its membranes, as well as the course of vital intracellular processes, reduce the mobility and virulence of microorganisms, as well as their ability to adhere. All of the above leads to the death of microorganisms.

An important feature of the drug and its difference from other drugs used for treatment Helicobacter pylori , it is believed that to date not a single strain has been identified that is resistant to the action of bismuth subcitrate.

The substance dissolves very well, due to which the medicine penetrates deep into the mucus layer and inactivates microorganisms located under the mucous membrane.

Thus, the use of De-Nol tablets reduces the likelihood of relapse peptic ulcer .

Gastrocytoprotective effect the drug is based on stimulating the body's production prostaglandin E2 ; improving microcirculation in the mucous membrane of the antrum of the stomach and duodenum; reducing the amount of hydrochloric acid; inactivation of pepsin due to the fact that this digestive enzyme forms complex compounds with bismuth subcitrate.

Bismuth subcitrate is practically not absorbed from the digestive tract after oral administration. A small amount of the substance can enter the systemic circulation, and its plasma concentration increases with long-term use. Bismuth subcitrate is eliminated from the intestinal contents.

Indications for use of De-Nol

Indications for use of De-Nol are erosive and ulcerative lesions of the gastric and duodenal mucosa .

In particular, the drug is prescribed for gastropathy that are a consequence of taking NSAIDs or alcohol; at gastroduodenitis and when (including if the diseases occur in or are associated with Helicobacter pylori); with aggravation (including if the disease is associated with Helicobacter pylori); with IBS ( irritable bowel syndrome ), as well as for functional, which is not related to organic lesions Gastrointestinal tract.

In some cases, it is considered advisable to use De-Nol and pancreatitis (especially in biliary-dependent patients). The drug is prescribed in complex therapy to eliminate gastroduodenostasis (hypomotor intestinal dyskinesia), which is often observed in the chronic form of the disease.

Contraindications

The drug has contraindications. It is prohibited to prescribe De-Nol:

patients with decompensated renal failure ;
pregnant women;
women who are breastfeeding;
children under 4 years of age;
with hypersensitivity to bismuth subcitrate or auxiliary components included in the tablets.

Side effects

Side effects of De-Nol on the part of the digestive system include nausea, vomiting, constipation or increased bowel movements. These phenomena do not pose a threat to the patient's health and are transient.

In some patients, treatment side effects may include hypersensitivity reactions (eg, skin itching or the appearance of skin rashes).

Long-term use of the drug in high doses can cause development due to the accumulation of bismuth in the central nervous system.

De-Nol tablets: instructions for use

The manufacturer in the instructions for use of De-Nol indicates that patients over 12 years of age should take 4 tablets per day.

There are two alternative ways to use De-Nol:

one tablet four times a day;
two tablets twice a day.

The tablets are taken half an hour before meals. They should be washed down with a small amount of water.

How to take De-Nol for children?

In accordance with the instructions for use of De-Nol, for children over 4 years of age, the optimal dose of the drug is calculated using the formula 8 mg/day. per 1 kg of body weight. Thus, depending on the child’s weight, the daily dose can be from 1 to 2 tablets. In this case, it should be as close as possible to the calculated value (8 mg/kg/day). You can take the medicine once, or you can divide it into two doses.

The duration of the course is from four to eight weeks. After completing treatment, you should avoid taking bismuth-containing medications for the next eight weeks.

Recipe in Latin for tablets:
Rp.: Tab. "De-Nol" N.112
D.S. 2 tablets 2 times a day

Why and how to drink D-Nol for diseases associated with H. pylori?

De-Nol is characterized by the ability to accumulate in the cells of Helicobacter pylori bacteria, which leads to their destruction cytoplasmic membranes and death of microorganisms.

This, as well as the property of bismuth subcitrate to dissolve well in gastric or duodenal mucus and prevent the adhesion of H. pylori to the epithelial tissue of the gastrointestinal tract, allows De-Nol to be used in a variety of schemes for the destruction of these microorganisms.

Frequent use antibacterial drugs And wide use anti-Helicobacter therapy has caused doctors to note a significant increase in the number of patients with antibiotic-resistant strains of H. pylori. Therefore, to solve the problem of eradication, treatment regimens that include backup agents are used.

The patient may often be prescribed De-Nol and, or.

240 mg bismuth subcitrate (De-Nol) twice a day for 30 days + 400 mg metronidazole and 500 mg three times a day for a weekly course (eradication - 81%);
120 mg bismuth subcitrate, 500 mg and 400 mg metronidazole four times a day for a weekly course (eradication - 89%);
240 mg bismuth subcitrate, 400 mg metronidazole and 250 mg clarithromycin twice a day for a 10-day course (eradication - 95%);
240 mg bismuth subcitrate twice daily, 500 mg Flemoxina Solutab , 100 mg furazolidone four times a day two-week course(eradication - 86%);
240 mg bismuth subcitrate, 200 mg furazolidone and 750 mg tetracycline twice a day for a weekly course (eradication - 85%);
240 mg bismuth subcitrate, 100 mg furazolidone and 250 mg clarithromycin twice a day for a weekly course (eradication - 92%);
240 mg bismuth subcitrate, 1000 mg Flemoxina Solutab and 250 mg clarithromycin twice a day for a weekly course (eradication - 93%);
120 mg bismuth subcitrate, 250 mg clarithromycin and 250 mg tetracycline four times a day for a 10-day course (eradication - 72%);
120 mg of bismuth subcitrate and 500 mg Flemoxina Solutab four times a day and twice a day 20 mg omeprazole two-week course (eradication - 77%);
120 mg bismuth subcitrate four times a day, 500 clarithromycin and 40 mg omeprazole twice a day for a weekly course (eradication - 83%).

The problem of eliminating H. pylori strains resistant to metronidazole , at the lowest cost allows you to use the drug De-Nol in combination with furazolidone .

The most effective from a clinical and economic point of view is considered to be the “bismuth subcitrate + amoxicillin + furazolidone ”.

The answer to the question “What should I take De-Nol with?” can only be given by the attending physician, depending on the characteristics of the course of the disease.

Overdose

A symptom of an overdose of De-Nol is a violation functional activity kidney The phenomenon is reversible, kidney function is completely restored after discontinuation of the drug.

Treatment of overdose involves performing a gastric lavage procedure, prescribing saline laxatives and enterosorbents. Further therapy is symptomatic.

If kidney dysfunction is accompanied sharp increase plasma concentration of bismuth, the patient is administered chelating agents (for example, or D-penicillamine ). In case of severe impairment of renal function, it may be necessary.

Interaction

The effectiveness of De-Nol may vary with simultaneous administration with other drugs, as well as food and liquids (in particular, with antacids , fruits, milk, fruit juices), for which it is considered optimal to take tablets half an hour before and half an hour after eating or taking any other medications.

Use of the drug in combination with tetracyclines reduces the absorption of the latter.

Terms of sale

Over-the-counter drug.

Storage conditions

Keep away from children, exposure to sunlight and moisture. The optimal temperature for storage is 15-25 °C.

Best before date

48 months.

special instructions

The annotation states that the maximum duration of the course of using De-Nol is 8 weeks.

During treatment, you should not exceed the dose of the drug prescribed by your doctor and do not take other bismuth-containing medications.

After completion of treatment with De-Nol, the plasma concentration of bismuth subcitrate ranges from 3 to 58 mcg/l. Symptoms of intoxication appear only in cases where the concentration of the substance exceeds 100 μg/l.

During the period of use of the drug, black stools are possible. The reason for this phenomenon is the formation of Bi2S3 (bismuth sulfide). Sometimes the tongue may darken slightly.

There is no data on the effect of De-Nol on the ability to operate machinery and drive a car.

Sometimes you can find the names De-Nol and Di-Nol, however, it is still correct to write De-Nol.

De-Nol - an antibiotic or not?

Despite their antimicrobial properties De-Nol does not belong to the group of antibiotics and, therefore, is devoid of their inherent side effects.

For specialists, the drug is interesting primarily because H. pylori does not have even the slightest possibility of developing resistance to it. The inclusion of De-Nol in the combined scheme anti-Helicobacter therapy allows you to significantly increase its effectiveness and, in most cases, completely get rid of the infection.

In addition, the drug enhances the protection of the gastric mucosa from the damaging effects of the digestive juice contained in it and promotes its restoration. These effects develop due to the fact that De-Nol turns into a colloidal solution in the stomach.

The solution particles form a protective film on damaged and inflamed areas of the mucous membrane, which accelerates tissue healing and prevents the formation of a rough scar. The latter is very important for preventing exacerbations of the disease.

The price of De-Nol analogues is from 20 Russian rubles.

Alcohol compatibility

During treatment with the drug, you should avoid drinking alcohol.

Taking De-Nol during pregnancy

De-Nol is contraindicated during pregnancy. It should also be avoided in breastfeeding women.