How much does your stomach hurt during embryo implantation? Embryo implantation

The birth of a new life is not like that easy process, as it really seems and as young couples planning to add to their family would like. After all, before forming an embryo and continuing its further development, male and female reproductive cells do a tremendous amount of work. If fertilization of a mature egg has occurred, it does not mean that pregnancy has occurred. It is much more important to know that the process of embryo implantation has taken place - the attachment of a fertilized egg to the walls of the uterus.

The female body is designed in such a way that approximately in the middle menstrual cycle he becomes ready for conception: a mature egg is released from the ovary, retaining its functions for another two days. This state is in gynecological practice called ovulation. If fertilization by sperm does not occur within these 12 or 24 hours, the female sex cell dies and is removed from next menstruation. When two or three eggs are ovulated, a woman can have several children at once.

At the same time, many other accompanying processes also occur: the consistency of the mucous secretions in the cervix becomes thinner, and the cervical canal expands to allow the passage of male reproductive cells, the woman’s mood changes, her desire increases, and the blood supply to the genital organs increases. The egg continues its development in the fallopian tube, moving to the farthest section to meet sperm, of which about 500 million are released as a result of sexual intercourse.

In order to “get” to the egg, they have to overcome the path from the cervix to the ampullary section (distant part fallopian tube), encountering certain obstacles along the way, since the vaginal environment is detrimental to sperm. Out of several million eggs, only a couple of three thousand reach the goal, where the most active ones retain their viability for about 5 more days. The female body helps them survive by creating a favorable habitat, because during ovulation a woman’s body temperature rises to 37 degrees. As is known, with these indicators sperm are most mobile.

After fertilization of a mature egg has occurred, the female sex hormone estrogen is activated, which prepares the uterine mucosa for the process of implantation of a fertilized egg into the uterus.

Embryo implantation: the essence of the process

It is amazing how many changes a woman’s body undergoes in order to conceive a child. And only after the embryo is implanted into the uterus can we talk about pregnancy.

After leaving the ovary, the fertilized egg reaches the uterus after 7 days, during which time it goes through 3 stages of development:

1. A zygote is a fertilized egg divided in two.
2. Then the morula, which has up to 32 cells, which undergo division every 15 hours. After 90 hours she has up to 64 cells. Of these, several form the fetus, and the rest will be involved in the formation of the membrane and placenta.
3. A fluid-filled blastocyst ball contains cells that will directly become an embryo.

After reaching the uterine epithelium, the blastocyst loses its protective shell and attaches to the wall of the uterus. If the membrane is too thick, implantation may not occur. Thanks to natural selection, only a healthy blastocyst manages to gain a foothold in the uterine lining. Otherwise, a pathologically “unhealthy” embryo may be rejected by the female body, and the pregnancy will be terminated.

The main reasons for failed implantation are:

• genetically abnormally developed blastocyst;
• the membrane of the fertilized egg is too thick;
• thickened uterine epithelium (normally this parameter should be 10-13 mm);
• lack of nutritional components in the uterine tissue.

Embryo implantation: on what day does consolidation occur?

As a rule, the introduction of a blastocyst into the uterine epithelium can occur from 3 hours to several days. During this period, the fertilized egg seeks comfortable spot, where it is tightly fixed due to troboblast. This process sometimes pauses for a while and then continues again. If the embryo has managed to establish itself well, then there is a high probability that it will overcome all sorts of difficulties in the future.

The woman’s body, in turn, at this stage is not yet ready to perceive the cells of the unborn child, reacting to them as foreign body. On early stages pregnancy he will try to get rid of this invasion, so during the implantation period to the expectant mother It is extremely important to behave very carefully and cautiously.

In obstetric practice, there are two conventional categories of the implantation process:

• late implantation embryo - occurs after the egg has been fertilized, approximately on the 10th day. It is especially favorable if artificial insemination is carried out. In cases where it would seem that pregnancy should not happen and is no longer expected, late implantation becomes a surprise;
• early implantation of the embryo occurs less frequently and occurs mainly on the 7th day after ovulation. It is generally accepted that during this period the uterus is not yet ready for implantation, but implantation is not excluded and pregnancy is still possible.

In order for the embryo to implant well and smoothly in uterine epithelium It is also necessary that certain conditions in the female body correspond to this:

• thickness of the uterine mucosa – no more than 13 mm;
• In order for the embryo to continue its vital activity in the walls of the uterus, the presence of certain nutrients is necessary;
• A woman's progesterone levels must be normal to promote embryo development and delay of menstruation.

Symptoms and signs of embryo implantation

After the embryo has strengthened, the level of the hormone begins to increase human chorionic gonadotropin(hCG) in a woman’s urine and blood. In parallel with this, during implantation of the embryo, the first signs of pregnancy appear. Among them:

1. Implantation bleeding is the first sign of embryo implantation in the uterus. This scanty discharge blood from the vagina, the amount of which sometimes does not exceed a few drops. Occurs as a result of damage small vessels on the wall of the uterus after the implantation of a fertilized egg. Discharge during embryo implantation should normally be beige-pink or Brown color. This symptom can be deceptive if a woman has current infectious diseases of the genital organs.
2. The process of embryo implantation, as a rule, is always characterized by such a symptom as pain. It can be nagging pain in the lower back or lower abdomen, sometimes even tingling. Usually painful sensations are localized at the site of embryo attachment.
3. Changes in basal and general body temperature. A characteristic reaction of a woman’s body to pregnancy is an increase in temperature (up to 37 – 37.3 degrees).
4. Metallic taste in mouth. This symptom often appears, so women should know that a metallic taste on the tongue is nothing more than a normal course of the process of fixation of a fertilized egg.
5. During embryo implantation, one of the woman’s feelings may be general malaise, which is accompanied by headache, apathy and dizziness.
6. Sharp changes in mood and psycho-emotional instability.

IVF and embryo implantation

Infertility today is a common diagnosis for many women for whom the method in vitro fertilization becomes a real salvation, a chance to give birth to a child on your own and become a mother.

Auxiliary reproductive technology IVF is the process of extracting a mature egg from a woman's body and fertilizing it in a laboratory. The embryo obtained after the procedure is stored in a special incubator for 2 to 5 days, after which it is transferred to the uterine epithelium.

Embryo implantation during IVF is clearly controlled by an ultrasound machine inpatient conditions. This procedure is painless and takes only a few minutes. During this procedure, a special plastic catheter with an embryo is inserted into the uterine cavity. When the fertility doctor sees on the screen that the device is in the optimal position, he releases the embryo from it along with a drop of nutrient. After implantation of the embryo, the woman remains in the hospital for about an hour.

Usually no more than two fertilized eggs are transferred, as more can lead to the development multiple pregnancy. The remaining embryos are frozen and stored for the purpose of being used in the future if implantation attempts fail. The traditional in vitro fertilization program involves embryo transfer on the 2nd day. However accurate results procedures at this stage of their development are unknown.

Research data suggests that implantation of 5-day-old embryos (blastocysts) after transfer into the uterine cavity increases the likelihood of pregnancy several times. In some cases, the fertility specialist decides to plant embryos twice: on the 2nd and 5th day or on the 3rd and 5th day. This greatly increases your chances of getting pregnant.

After this procedure, doctors strongly recommend that women not visit the sauna, avoid physical activity, sex life and alcohol consumption. Regular use of hormonal medications should be mandatory.

Pre-implantation studies

Before transplanting an embryo, a reproductive specialist must assess its condition. The healthiest and highest quality ones that can adapt and survive well are subject to replanting. Such preimplantation diagnostics allows us to identify possible hereditary syndromes, and also determine gender fetus

The successful outcome of embryo implantation after transplantation is also influenced by the condition of the uterus, so before the procedure, doctors must study the size of the endometrium, its structure, length of the organ, condition internal pharynx. An ultrasound machine is used. When transferring a fertilized egg, you should avoid touching the fundus of the uterus with instruments, as this can lead to an increase in tone and subsequently to a miscarriage.

The optimal number of embryos to be transferred directly depends on gynecological history women (presence of abortions or pregnancies in the past). Age and quality also influence planting material. For women under 35 years of age, up to 2 embryos are transferred during the first IVF cycle. Large quantity Women after 40 will need it, since at this age the likelihood of implantation is much reduced.

The successful outcome of the operation is also influenced by the diagnosis of the woman or man, the professionalism of the doctors and the quality of the in vitro fertilization procedure performed.

Embryo implantation during IVF has its own characteristics. An embryo implanted in a woman’s uterus was conceived outside the woman’s body, and therefore requires additional time to adapt. Because of this, the procedure ends successfully only in a third of all cases. Additionally, to reduce the risk of embryo failure, a woman should take care of her body:

• sleep well and relax in the fresh air more often;
• do not lift heavy objects;
• you should stop taking hot baths for a while;
• stop having sex temporarily;
• it is not recommended to overcool and, conversely, overheat the body;
• you need to eat well and not go on strict diets;
• try to monitor your immunity and avoid staying in crowded places where viral infections may occur.

A woman needs to be in this state of caring for herself and her unborn baby at least until the 20th week of pregnancy: during this time the placenta will form and the fetus will be additionally protected. According to obstetricians, the implantation process continues all this time, and only then the baby begins to actively grow and develop.

Embryo implantation. Video

At favorable conditions, seven days after the fertilization of the egg, pregnancy occurs. But, in some cases, this may not happen, due to the fact that implantation of the embryo did not occur. Expectant mothers are interested in why the embryo does not attach to the uterus and what are the reasons.

Time for embryo attachment

For pregnancy to occur, the fertilized egg must develop into a zygote and implant in the uterus. After this, it can be considered an embryo. In order for an embryo to take root in the uterus, its walls must be ready to receive it.

According to doctors, conception can be early or late. With early implantation, occurring no later than seven days after ovulation, female body is not yet prepared to receive the embryo, the endometrium does not have the required thickness. But such cases happen infrequently. Late attachment usually occurs on the tenth day after fertilization. This period is considered the most favorable when carrying out the IVF procedure.

Attachment of the fertilized egg natural pregnancy, takes a minimum of 48 hours and they are decisive.

If, at this time, the woman’s body perceives the embryo as foreign body, the embryo may not attach to the uterus, rejection will occur and menstruation will occur. A woman is considered pregnant after the implantation and consolidation of the fertilized egg in the uterus. This takes from one to three days.

In the protocol, the future embryo develops outside the female body, it is implanted when it is already mature, and it is able to take root faster than in a natural pregnancy. This is the difference between IVF and natural conception. Embryos aged 3–5 days have the highest survival rate.

Factors that interfere with implantation

With artificial insemination, pregnancy does not occur in all cases. In order to determine why there is no implantation, doctors find out all the reasons for the embryo not attaching to the uterus during IVF. Sometimes, the egg does not attach to the uterus and conception does not occur.

The reasons for unsuccessful embryo implantation are:

1. the presence of endometriosis, fibroids;
2. too thick or thin layer endometrium, the thickness of which is ideally from 10 to 13 millimeters;
3. a large number of abortions;
4. genetic abnormalities in the embryo, preventing it from attaching;
5. low levels of the hormone progesterone, which is responsible for creating conditions for fetal development.

Compliance with the last point is of no small importance.

For 12 - 14 days after the transfer, the woman is advised to follow a gentle regimen and refuse physical activity, avoid stressful situations.

Lack of implantation during IVF:

• low-quality biomaterial;
• pathological changes in the endometrium;
• hydrosalpinx tubes;
• unqualified support during the protocol;
• ignoring doctor's orders.

What happens if the embryo does not attach to the uterus? If the fertilized egg does not attach, the so-called spontaneous termination of pregnancy occurs at a very short time. Sometimes, a miscarriage occurs after implantation, when the body begins to produce the pregnancy hormone and the test shows a positive result.

Attachment of the embryo

The beginning of the natural implantation period is considered to be the time when an embryo with at least 16 cells enters the wall of the uterus and the egg enters the mucous membrane.

The attachment of the fertilized egg in the protocol differs from natural conception in that it is more quickly implanted.

How the embryo attaches to the uterus during IVF:

• in the first two days, a zygote is formed from the oocyte, from which an embryo has four cells by the end of the second day;
• on the third day there are already eight cells, the embryo is ready for transfer, but the likelihood of pregnancy due to its immaturity is low, and further cultivation occurs to the blastocyst stage, which occurs on the fifth day. This period is considered the best for transfer;
• after replantation, within 48 - 72 hours, under favorable conditions, the fertilized egg attaches to the walls and begins to grow, as in a natural pregnancy. But, in order for this to happen, the embryo itself must have the ability to further develop.

It is possible to enter the uterus at the age of 2-4 days, but this is impractical, and the chances of a successful pregnancy are low. After implantation, you need to wait at least two weeks to confirm a positive result.

The fertilized egg attaches to different places. If the embryo has attached high in the uterus, it means that it has implanted close to its bottom, which is the most favorable for it further development. If the embryo does not attach, another menstruation occurs, and the fertilized egg is released along with the discharge.

Helps in the attachment of the embryo

Many patients who have entered into the protocol are interested in the question of why the embryo does not attach to the uterus during IVF. This is influenced by many factors, to eliminate which it is carried out additional treatment, increasing the chances of a successful transfer.

The reason that the fruit did not attach may be poor quality endometrium with increased or decreased immune activity. In order to help the embryo settle in the uterus during IVF, it is prescribed additional procedures, providing positive effect on the condition of the endometrium, and helping further implantation.

For example, with a deficiency of immune activity, injection of seminal fluid into the uterus, local irritation of the mucous membrane helps, and if it is too high, intravenous administration immunoglobulin, follicular fluid into the uterus and other methods.

What to do if the embryo does not attach to the uterus? There are several factors that influence the fact that the embryo cannot attach. These are female pathologies reproductive system, gynecological diseases and genetic abnormalities in the fertilized egg itself. In this case, a detailed ultrasound examination, taking tests to identify the causes. With constant unsuccessful attempts to get pregnant naturally, it is recommended to use the IVF procedure. But it is important to remember that it does not provide a complete guarantee.

When will the embryo come out if it has not attached to the uterus? If the embryo does not take root, it means that the fertilized egg has stopped in its development and will be released from the body during the next menstruation. If the desired pregnancy does not occur, there is no need to despair. You should contact highly qualified specialists who will help you find out all the reasons that are preventing embryo implantation and prescribe the necessary treatment.

Today, families who naturally cannot, resort to. This procedure is expensive and complicated, but if it is successful, the married couple will become happy parents in 9 months.

In vitro fertilization consists of several stages, the most important of which is the implantation of the embryo into the woman’s body. This procedure is not considered difficult, but in order for pregnancy to occur, everything must be done strictly according to the rules of both the doctors and the woman.

Examination before embryo implantation

Before a fertilized egg is implanted into the body, a woman must undergo examinations. Thus, the condition of the uterus, its length and wall thickness are studied. If muscle tone is observed, the woman is prescribed relaxing medications before IVF.

Before implantation, it is necessary to determine the condition of the uterine walls. They must contain nutrients required for fetal development. If some substances are missing, pregnancy may not occur.

Before embryo implantation takes place, a woman must undergo hormone tests. In her body sufficient quantity must, necessary for normal gestation.

Before implantation, the embryo is also examined. Of all the fertilized cells, reproductologists select only healthy ones. After all, already at this stage it is possible to diagnose genetic diseases in the embryo.

But even if the procedure was carried out without violations, embryo implantation may not occur. This happens by various reasons. The embryo may have some genetic disease, not diagnosed before egg transfer. Often these diseases prevent pregnancy from developing.

The reason may be painful condition uterus, due to which the embryo cannot attach to it. It could also be infection or mechanical damage, applied by the instrument during cell transfer.

Timing of embryo implantation

When a fertilized egg enters the female body, it must move through the fallopian tube. It is considered normal for embryo implantation to take place on the seventh day after artificial insemination eggs. If the procedure is successful, the embryo should attach to the wall of the uterus within 40 hours. After attachment, it begins to develop in the same way as an embryo that appears naturally.

Doctors never rule out late embryo implantation, which occurs 10 days after the fertilized egg is implanted. That's why married couples It is recommended to believe in the success of the procedure until the last moment, because pregnancy can occur even when it is not expected.

After embryo implantation, the amount of human chorionic gonadotropin increases in the blood. It is from the moment the level of this hormone increases that the embryo can be visualized on ultrasound. Therefore, late implantation of the embryo cannot be ruled out and hCG should be done periodically - this will allow time to determine the onset of pregnancy and begin to monitor the development of the baby in the early stages.

Signs of successful embryo implantation

After successful implantation of the embryo, the woman begins to experience certain sensations that she did not have before. At first, her breasts begin to hurt slightly and become enlarged. Pain is felt in the lower abdomen. A sign of implantation of the embryo into the uterus is not acute, but dull and nagging pain.

An important symptom of embryo implantation is the appearance of pink or dark brown colors. They often indicate pregnancy.

Sensations during embryo implantation may be similar to symptoms food poisoning. There is a constant metallic taste in your mouth, and when you see food you feel nauseous and start vomiting.

Signs of embryo implantation into the uterus are:

• irritability,
• dizziness,
• weakness,
• headache,
• prostration,
• excessive emotionality,
• mood swings,
• depression

Don't confuse pregnancy with a cold. After all, with successful implantation, chills and an increase in temperature to 37 and 3 may be observed for several days. If you are expecting pregnancy and the temperature begins to rise, you should not take antipyretics and antiviral drugs– this can harm the embryo and terminate the pregnancy.

After IVF, a woman needs to listen especially carefully to her body. If you do experience any of these symptoms, it is necessary to find out for sure whether you are pregnant or not.

Regardless of whether natural or artificially implantation of the embryo has occurred, it has the same type of symptoms: pain in the very bottom of the abdomen, nausea, bleeding, dizziness. In any case, if you have such symptoms, do not delay going to the doctor, because early examination can prevent miscarriage and the development of pregnancy pathologies.

Embryo implantation

Embryo implantation

Implantation is the process of “ingrowth” of an embryo into the uterine mucosa. After this, pregnancy occurs and the fertilized egg begins to develop.

In natural fertilization, embryo implantation is possible after the fertilized egg passes through fallopian tube and enters the uterine cavity. Embryo implantation during IVF occurs after the procedure of transferring it into the uterus.

On what day does embryo implantation occur?

Pregnancy after IVF occurs only if the embryo has been implanted. It is impossible to say exactly on what day this happens, because the process of implantation of the embryo into the endometrium takes a certain time.

Reproduction doctors calculated how long embryo implantation takes and found that the duration of this process is about 40 hours. However this average duration. There is no strictly limited time period during which embryo implantation will continue.

It is impossible to find out on what day the “introduction” of the blastocyst into the uterus should be considered complete, since this is a gradual process, not a one-step process. It can take from several hours to several days.

After implantation of the embryo, pregnancy occurs. This can happen in different time. Usually - on the 6-7th day after ovulation, respectively, on the 2-3rd day after the transfer. Sometimes there is late implantation of the embryo. In this case, the “ingrowth” of the blastocyst into the uterine mucosa occurs on the 10th day after ovulation or later.

If the IVF procedure is successful, the fertilized egg begins to produce hCG, and very soon the pregnancy can be established in the laboratory. The uterus begins to enlarge after implantation of the embryo. By its size you can judge the timing of pregnancy.

Conditions for embryo implantation

There are certain conditions under which implantation of the embryo after transfer will take place with more likely. These include:

• endometrial thickness – optimally it should be 9-11 mm, minimum – from 7-8 mm;
• normal blood circulation in the uterine mucosa;
• normal level sex hormones in the blood, primarily progesterone;
• woman's age is up to 35 years.

Some conditions can be affected. Therefore, a woman in an IVF protocol is prescribed progesterone preparations or synthetic analogues of this hormone to stimulate endometrial maturation.

If there is a circulatory disorder in the uterine mucosa, there are special drugs and procedures that help normalize blood flow. After these measures, successful embryo implantation becomes more likely.

U older women The egg shell may be too thick. If the embryo fails to “reset” it, then implantation of the embryo into the uterus will not take place. To facilitate this process, a procedure called assisted hatching is used. In certain categories of patients, this increases the chance of success.

The opposite situation is also possible. Proliferative diseases of the endometrium - hyperplasia, polyps - prevent successful implantation. Then a procedure called scratching is carried out. Its essence is that “notches” are applied to the endometrium, making it easier for the blastocyst to penetrate into the thickness of the uterine mucosa.

Scratching is done at the height of the secretory phase preceding the planned pregnancy of the menstrual cycle, in order to improve endometrial blood flow, stimulate endometrial growth in proliferative phase next cycle.

Unfortunately, pregnancy does not always occur after the transfer procedure.

Possible reasons why embryo implantation did not occur after IVF:

1. the endometrium is not ready to accept an embryo;
2. the embryo has defects in the genetic material and is therefore rejected;
3. the reason is unknown - even high-quality embryos are not always implanted into the well-prepared uterine mucosa.

If the cycle fails, the transfer should be attempted again - cryoprotocol. Sooner or later, implantation of the embryo will occur after ovulation, and pregnancy will occur.

Signs of embryo implantation

There are no pathognomonic (characteristic only for this process) symptoms of embryo implantation. A woman is unable to feel or otherwise determine the time of embryo implantation.

Sometimes during the first days after the transfer the following symptoms are observed:

• aching pain in the lower abdomen;
• tingling in the mammary glands;
• weakness, dizziness;
• emotional lability;
• slight increase in body temperature;
• change in taste;
• light discharge from the vagina.

Some women, on the day of embryo implantation, experience scanty (spotting) bleeding from the vagina, a metallic taste in the mouth, and decreased basal temperature bodies.

However, the presence of these symptoms does not mean that embryo implantation has occurred. Sensations and objective signs may not be caused by pregnancy, but by the use of hormonal drugs.

Embryo implantation after IVF transfer. What is late implantation

Will the transferred egg fall out after replantation? What are these? These questions are the most common among future IVF mothers.

We will look at what is necessary for full blastocyst implantation, what to do to make it happen, and the differences between embryo implantation during IVF.

• Implantation conditions
• Features of implantation in IVF protocols
• When does embryo implantation occur after transfer?
• The immune system
• Medication support
• Signs of embryo implantation after transfer. Symptoms
• Can embryos fall out?

Conditions for implantation during IVF

The mechanism of embryo implantation after transfer (during IVF) is theoretically no different. The process is little studied even in natural cycles. It is known that it can extend over time and consists of two main phases: adhesion and adhesion (or penetration).

Necessary conditions for success:

• Active. Provided with the preparedness of the cells of the uterine mucosa.

• Produced on time.

Reproductologists have such a concept as an implantation window. This is the period during which the uterus is able to interact with the embryo. The implantation window is limited in time, so the effectiveness of IVF largely depends on the timeliness of transfer to the uterus.

The peak of receptivity - the ability of endometrial cells to interact with the embryo - occurs on days 20–21 of the cycle, but can shift depending on the drugs used for stimulation, the body’s sensitivity to them and the duration of the menstrual cycle. Most often, the implantation window opens at 20–21 days. natural cycle, with controlled stimulation of ovulation - by 19–20, with replacement hormone therapy– on days 21–22.

In addition, IVF is characterized by a lengthening of the interval during which implantation occurs - it lasts up to 3 days. Normally the process lasts 40 hours.

Late implantation does not affect pregnancy outcome. But defective embryo implantation after transfer - common reason spontaneous abortion.

When does embryo implantation occur after transfer?

It is reliably known that embryo implantation occurs after transfer, when hatching is completed. After transferring three-day-old embryos at the morula stage, initiation of implantation occurs 2–3 days after transfer (2 and 3 DPP). After - on the same day or the next day.

The immune system

The role of the immune system in the implantation process has not been thoroughly studied. It is certain that it has an impact. Pregnancies after IVF are associated with the presence of antithyroid, antiphospholipid antibodies, activated natural killer cells - NK in the blood serum of women.

For a long time it was believed that with the immune system is suppressed so that there is no conflict between the mother’s body and the protein molecules of the embryo. Scientists have proven that cellular interactions actually occur and become more complex. The appearance of atypical reactions leads to implantation disorders at the stage of adhesion and invasion.

Reasons for the absence or failure of implantation

There are several reasons why embryo implantation after transfer becomes unsuccessful:

• . The reason is a poor-quality genome formed during fertilization.
• Endometrial receptivity is impaired. Causes – consequences of infectious inflammatory processes, hormonal regulation disorders.
• The embryo cannot get rid of the thickened protein membrane on its own. This often occurs in older patients and is associated with. Other reasons - embryo transfer after ovulation, prolonged hormonal induction of ovulation, malfunction endocrine organs, smoking, embryo cultivation in an artificial environment.

Medication support

To increase the likelihood of successful implantation after embryo transfer, progesterone support is prescribed, starting from the day of the puncture (or no later than 3 days after the puncture). Under the influence of drugs, the transformation (preparation) of the endometrium for the expected implantation is initiated.

Support regimens contain blood thinning drugs: heparin and its analogues, aspirin. Under their influence, blood flow in the uterus increases, conditions for implantation improve.

Signs of embryo implantation after transfer and symptoms

Individual sensations – dizziness, metallic taste, weakness, malaise, increased basal and general body temperature and others are difficult to attribute to symptoms of embryo implantation after transfer. They may be associated with previously performed progesterone, prescribed to support implantation, or the result of “soul-searching” - looking for signs of an upcoming pregnancy.

A significant sign of embryo implantation after transfer is implantation bleeding, which is rare. It can easily be confused with bloody discharge, occurring due to insufficient support of the luteal phase. Therefore, only your Mr. can judge the nature of their origin.

Can embryos fall out?

Nature is wise, embryos do not fall out either after artificial transfer to, or to.

Inside the uterus - on the mucous membrane - there are many villi. As soon as the embryo comes into contact with them, they envelop and hold it. In addition, the uterus hollow organ, but its walls are adjacent to each other. Once hatching has occurred, the exposed embryo adheres. The outer cell mass surrounding the embryo is very sticky.

In conclusion, watch the video - the opinion of a specialist obstetrician-gynecologist-reproductologist, Ph.D. Kamenetsky Boris Aleksandrovich about whether embryos can fall out of the uterine cavity.