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Tradename drug: Caffeine sodium benzoate

International nonproprietary name:

caffeine

Dosage form:

solution for subcutaneous and subconjunctival administration

Compound

1 ml of solution contains 100 mg or 200 mg of sodium caffeine benzoate as an active substance and Excipients- sodium hydroxide 0.1 M solution and water for injection.

Description

Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:

psychostimulant

ATX code:

Pharmacodynamics

It has a psychostimulating and analeptic effect. It has a stimulating effect on the central nervous system (CNS), increasing excitation in the cerebral cortex, respiratory and vascular-motor centers, and activates conditioned reflexes and physical performance, reduces drowsiness and fatigue, causes deepening and rapid breathing, increases heart rate, increases arterial pressure with hypotension, dilates the bronchi, biliary tract, blood vessels skeletal muscles, reduces platelet aggregation, has a moderate diuretic effect, stimulates secretion gastric juice, increases basal metabolism and enhances glycogenolysis, causing hyperglycemia. Multiple pharmacological effects the drug is caused by blockade of central and peripheral adenosine receptors. Inhibits phosphodiesterase, which leads to intracellular accumulation of cyclic adenosine monophosphate, under the influence of which glycogenolysis processes are enhanced, metabolic processes in organs and tissues are stimulated, including muscle tissue and the central nervous system.

When administered subconjunctivally, it improves microcirculation and activates the metabolic processes of the ciliary epithelium.

Pharmacokinetics

It is quickly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumin) - 15%. More than 90% is metabolized in the liver, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is demethylated and oxidized) with the formation of 5 metabolites. Caffeine and its metabolites are excreted by the kidneys (10% unchanged).

Indications for use

• Decrease in mental and physical performance, muscle weakness, drowsiness, migraine, moderate arterial hypotension, respiratory depression (including mild poisoning with opioid analgesics and sleeping pills, carbon monoxide, with asphyxia of newborns, restoration of the required level of pulmonary ventilation after the use of general anesthesia).
• Hypotension eyeball(after abdominal eye surgeries, ciliochoroidal retinal detachment, hypotonic retinal detachment).

Contraindicated

Hypersensitivity, organic diseases of cardio-vascular system(incl. acute heart attack myocardium, atherosclerosis), arterial hypertension, glaucoma, sleep disorders, increased excitability, elderly age, paroxysmal tachycardia, frequent ventricular extrasystole, epilepsy and a tendency to seizures. Pregnancy and lactation period.

Carefully: glaucoma, increased excitability, old age.

Directions for use and doses

Subcutaneously: adults 100 mg or 200 mg. Higher single dose for adults it is 400 mg, the highest daily dose is 1 g. For children, 25-100 mg depending on age. In ophthalmology, 30 mg is administered subconjunctivally once a day, daily. The number of injections depends on intraocular pressure and depth of the anterior chamber.

Side effect

From the outside nervous system: agitation, anxiety, tremor, headache, dizziness, epileptic seizures, increased tendon reflexes, tachypnea, insomnia. With sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness, increased muscle tone.

From the cardiovascular system: tachycardia, cardiac arrhythmia, increased blood pressure.

From the outside digestive system: nausea, vomiting, diarrhea, exacerbation peptic ulcer.

Others: nasal congestion.

At long-term use Possible mild addiction (decreased action is due to the formation of new adenosine receptors in brain cells), drug dependence.

Overdose

Symptoms: increased severity side effects. In newborns (including premature infants) the following are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, with more high concentrations- convulsions.

Treatment: symptomatic therapy, oxygen therapy, hemodialysis. In newborns, if necessary, exchange transfusion blood.

Interaction with other drugs

At joint use caffeine and barbiturates, primidone, antiepileptic drugs (hydantoin derivatives, especially phenytoin) may increase metabolism and increase caffeine clearance.

Concomitant use with cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin leads to a decrease in the metabolism of caffeine in the liver, a slowdown in its elimination and an increase in concentration in the blood.

When used with caffeinated beverages and other drugs that stimulate the central nervous system, excessive stimulation of the central nervous system is possible. Caffeine is an adenosine antagonist - large doses of adenosine may be required.

Mexiletine - reduces caffeine excretion by up to 50%; nicotine - increases the rate of caffeine elimination.

Monoamine oxidase inhibitors (MAOIs), furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.

Caffeine reduces the effect of narcotic and sleeping pills. Increases the excretion of lithium preparations (Li +) in the urine.

Accelerates absorption and enhances the effect of cardiac glycosides. increases their toxicity.

Concomitant use of caffeine with beta-blockers may result in mutual suppression therapeutic effects; with adrenergic bronchodilators - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.

special instructions

It should be borne in mind that sudden cessation of use may lead to increased inhibition of the central nervous system (drowsiness, depression). The effect on the central nervous system can be manifested by both excitation and inhibition of higher nervous activity.

Release form

Solution for subcutaneous and subconjunctival administration 100 mg/ml or 200 mg/ml. 1 ml or 2 ml of 10% (100 mg/ml) or 20% (200 mg/ml) solution in neutral glass ampoules. 10 ampoules with instructions for use and a knife for opening ampoules or an ampoule scarifier in a cardboard box or 5 or 10 ampoules in a blister pack made of polyvinyl chloride film, 1 or 2 blister packs with instructions for use and a knife for opening ampoules or with an ampoule scarifier in a cardboard pack. When packaging ampoules with a break ring or break point, a knife for opening ampoules or an ampoule scarifier is not included.

Storage conditions

List B.

At temperatures from +15°C to +25°C Store out of the reach of children.

Best before date

6 years. Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies:

on prescription.

The manufacturer accepts claims from buyers:

OJSC "Novosibkhimpharm", 630028, Russia, Novosibirsk, st. Dekabristov, 275

Caffeine sodium benzoate - medicine synthetic production made on the basis of caffeine. This alkaloid, which has a psychostimulating, analeptic effect, is obtained from tea leaves and coffee beans. The caffeine content of kola plant nuts is especially high.

The drug increases intellectual and physical performance, promotes increased motor activity, and activates mental activity. Helps reduce reaction time, and also reduces fatigue and eliminates drowsiness. It has a dual effect: small doses have a stimulating effect, large doses depress the nervous system.

How is caffeine sodium benzoate used, instructions for use, what information does it give about the medicine, what is its use, action, composition, dosage, overdose, what analogues does it have? You can find out about all this by reading this detailed description.

The text is based on the factory instructions, but is not such. The description is intended only to introduce the drug. Before using the medicine, you should independently study the instructions supplied with it.

Compound

Each tablet contains active agent caffeine sodium benzoate 0.1 - 0.2 g.
For 1 ml of solution for injection accounts for 0.1-0.2 g of caffeine sodium benzoate.

Therapeutic effect

The drug is intended to stimulate the central nervous system. The caffeine it contains activates and regulates excitation processes in certain areas of the cerebral cortex. This substance also activates positive reflexes, improves motor activity.

After taking the drug, mental and physical performance increases. Fatigue decreases, drowsiness decreases.

It must be remembered that taking this medicine may weaken the effect of sleeping pills, as well as narcotic drugs, increases reflex excitability in spinal cord. In addition, the drug activates the respiratory and vasomotor centers of the body. As a result, the work of the heart muscle is enhanced and activated, its contractions become more frequent and intense.

Increases breathing speed and makes it deeper. It has a positive ino-, chrono-, batmo-, dromotropone effect.

Analogues of the drug

Medicines such as Dia-Activanad-N and Caffeine have a similar effect.

Indications for use. What do the instructions say?

This drug is recommended for use when complex treatment diseases that cause depression of the central nervous system and cardiovascular system. In particular, the drug is prescribed for hypotension, migraine, as well as asthenic syndrome. For headaches, take a tablet of the drug, sometimes in combination with other drugs, for example, acetylsalicylic acid(aspirin).

Application, dosage

Pills:

Take orally 2-3 times a day. Required dosage calculated by the doctor. According to the instructions, usually a single dose for adults is 0.1-0.2 g. The permissible single dose is 0.5 g. The daily dose is 1.5 g.
For children (5 - 14 years old) a single dosage is 0.025-0.1 g, 2-3 times a day.

Solution for injection (administered subcutaneously):

Adults - 10% (20%) 1 ml 2-3 times a day. No more than 0.4 g one-time, no more than 1 g per day.
Children (dosage depends on age) - 10% 0.25-1 ml 2-3 times a day.
It must be remembered that with regular long-term use the drug is addictive.

Overdose

When taking too large a dose, mental agitation occurs. Patients complain of vomiting, dizziness, rapid breathing, and convulsions. In case of overdose, you should immediately rinse your stomach and then take the tablets activated carbon. In case of poisoning, oxygen therapy is carried out after washing. Convulsions are eliminated with diazepam.

Contraindications for use

The drug is contraindicated in patients with increased excitability. It is not taken for hypertension or atherosclerosis. It is contraindicated for insomnia, as it can worsen it. Caffeine sodium benzoate is not prescribed to patients with organic diseases heart and blood vessels, as well as those suffering from glaucoma. It is contraindicated for elderly people, as well as children under 5 years of age.

Consult your doctor before use. Be healthy!

This is a psychostimulant with an analeptic effect, a derivative of methylxanthine.

Composition and release form

Caffeine sodium benzoate:

• Available in 100 mg tablets. There are 6-10 tablets in a pack, 2 packs in a pack.
• Available in ampoules, ampoules of 10% solution of 1 ml and 2 ml in a package of 10 pieces; ampoules of 20% solution of 1 and 2 ml in a package of 10 pieces.

List B. Store in the ear, cool, out of the reach of children.

Composition of the product

Pills white, flat-cylindrical in shape, with beveled edges and a notch;

• 1 tablet contains active substance caffeine sodium benzoate in terms of 100% substance - 0.2 g;
• Excipients: lactose monohydrate, microcrystalline cellulose, corn starch, povidone, calcium stearate.

pharmachologic effect

Caffeine sodium benzoate blocks central and peripheral A1 and A2 adenosine receptors, and also inhibits PDE activity in the central nervous system, smooth muscle organs, adipose tissue, heart and skeleton. The drug promotes the accumulation of cAMP and cGMP in them. The medication stimulates the centers medulla oblongata(respiratory and vasomotor), has a stimulating effect on the cerebral cortex. At high concentrations, the drug facilitates interneuronal conduction in the spinal cord, which significantly enhances reflexes.

The use of the product helps improve performance, both mental and physical, it actively stimulates mental activity, promotes the growth of motor activity, makes reactions faster, and also has a temporary effect of reducing drowsiness and fatigue. However, in large doses, the drug depresses the nervous system, it is indicated in small doses, then it helps stimulate the body.

The medication has a vasodilating effect, which is explained by its relaxing effect on the walls of blood vessels. Tone cerebral arteries increases, blood pressure changes under the influence of caffeine. The medication, for hypertension, normalizes blood pressure, and for normal pressure has no effect on him.

The drug also speeds up breathing and has an antispasmodic effect on smooth muscles, and it stimulates striated muscles. Slightly increases the secretory activity of the stomach. The drug also reduces platelet aggregation and slows the release of histamine from mast cells.

Indications for use of Caffeine Sodium Benzoate

The drug is indicated for depression of the central nervous system, for poisoning drugs and insufficiency of the cardiovascular system.

Caffeine sodium benzoate helps with diseases that are accompanied by depression of the nervous system, cardiovascular and respiratory systems. The drug is an excellent remedy in case of poisoning with opioid analgesics, infectious diseases, the occurrence of brain spasms. The drug helps well with mental and physical fatigue, increases human performance. Reception is indicated in a state of constant drowsiness.

The drug is often taken by athletes to increase physical activity before competitions. This allows for more frequent and intense training.

Contraindications

The drug is contraindicated in the following cases:

• Insomnia.
• Increased excitability.
• Persistent rise in blood pressure.
• Glaucoma is increased pressure inside the eyes.
• Atherosclerosis.
• Diseases of the cardiovascular system.
• Senile age.

Side effects

Side effects of Caffeine Sodium Benzoate are:

• Caffeineism is an excessive addiction to active substance. Occurs when long-term use drug.
• Sleep disorders.
• Constant feeling of anxiety.
• Tachycardia.
• Increased blood pressure.
• The occurrence of arrhythmia.
• Nausea.
• Vomit.

Symptoms disappear after stopping taking the substance.

Instructions for use

Method and dosage

The medication is available in the form of solution and tablets. The solution is administered subcutaneously, the tablets are taken orally. Adults are prescribed 1-2 ml of a 10% or 20% solution under the skin once a day. Tablets are prescribed 100-200 mg 2-3 times a day for adults and 25-100 mg 2-3 times a day for children.

Caffeine sodium benzoate for weight loss

A standard tablet gives an effect of the same intensity as a cup of strong natural coffee. Within a few hours after its use, a surge of strength is felt, the rhythm of breathing and heartbeat increases, and blood pressure rises. The body is in an active state, and therefore the body spends much more energy burning fat, which leads to intense fat burning.

If you exercise after taking Caffeine Sodium Benzoate tablets, you can achieve better effect. In addition, after taking the product, blood flows to the skin through the vessels, which allows you to quickly remove toxins accumulated in the body, get rid of swelling and open the access of oxygen to the body, which also helps burn fat.

In order to achieve an effect in losing weight, the drug is taken half an hour before training, it is necessary to take 1 tablet per 30 kg of weight, but total number tablets should not exceed 4 pieces.

Caffeine sodium benzoate for children

During pregnancy and lactation

It is not recommended to take it, as excessive activity can increase the already heavy load on the heart and also negatively affect the development of the fetus. However, in some cases, with very low blood pressure in pregnant women, caffeine is prescribed for use.

Overdose

Cases of overdose occur extremely rarely. In this case, abdominal pain, a feeling of increasing anxiety, agitation, mental and sometimes motor agitation, clouding of consciousness, dehydration, headache, tremor, excessive sensitivity to touch, hyperthermia, frequent urination. Nausea, vomiting blood, and ringing in the ears may occur. IN in rare cases epileptic seizures are observed.

Overdose may occur when taking a dose of 300 mg. If symptoms occur, gastric lavage is prescribed (in the absence of vomiting and provided that caffeine has been taken recently), taking activated charcoal and laxatives. It is necessary to maintain ventilation and water balance, prevent dehydration.

special instructions

Sudden cessation of use leads to inhibition of the nervous system, causing excessive drowsiness and depression. The influence can be expressed both in excessive excitability and in inhibition of reactions. Depending on the characteristics of the body, taking medication may have a stimulating or cardiac depressing effect on blood pressure.

It is not recommended to drive a car and perform life-threatening work, operate machinery, and perform any activities that require concentration while using the drug, as it can affect the speed of psychotropic reactions.

Caffeine sodium benzoate is quite addictive, so you should not take this drug for a long time. To achieve optimal effect, you must take the medicine for a month. From time to time, the drug can be taken for several years in a row.

Interaction with other drugs

• Simultaneous use of the drug with oral contraceptives, such drugs as ciprofloxacin, disulfiram, norfloxacin, cimetidine, can cause its slow elimination from the liver and increase the level of the drug in the blood.
• It is not recommended to combine the use of the drug with drinks and other medicinal substances with caffeine content, as this leads to excessive excitability. Nicotine in the body increases the rate of elimination of the drug, and mexiletine reduces the rate of elimination.
• You should not combine Caffeine sodium benzoate with sleeping pills, as it removes the effect of sleeping pills and sedatives. The medication interferes with the absorption of calcium by the stomach, reduces the effect of narcotic drugs on the body, ensures rapid absorption of cardiac glycosides and promotes the rapid excretion of lithium in the urine.

Domestic and foreign analogues

Analogue of the product - Sidnocarb

The drug has active influence on the central nervous system. Sidnocarb has no obvious peripheral activity and is not addictive even with long-term use. With prolonged or repeated therapy, a weakening of the effect is not observed. This analogue is indicated for use against weakness caused by physical or psychological fatigue, for neurotic disorders, and after traumatic brain injury. Indicated in the complex treatment of mild schizophrenia.

Phenamine - analogue

Active stimulant of the nervous system. The drug is characterized by peripheral action. Helps with chronic weakness, depression, and also for stimulation labor activity. The drug, when taken for a long time, causes addiction.

Analogue of Caffeine sodium benzoate - Etimizol

The drug has a stimulating effect on the nervous system and also promotes the functioning of the respiratory system. Actively used in psychiatry. This analogue is indicated for states of depression, constant feeling anxiety and weakness. The use of the drug helps in stimulating the airways after anesthesia and is used as preventive action against pneumonia after operations.

Analogue - Dia-Activanad

A drug with a nervous system stimulant and analeptic effect. Stimulates Airways, cerebral cortex, vasomotor centers. This analog increases mental and physical activity, reduces fatigue and drowsiness. With hypotension, it increases blood pressure, and also helps to increase the strength and frequency of the heart and the secretion of the gastric glands.

Price in pharmacies

The price of Caffeine Sodium Benzoate in different pharmacies may vary significantly. This is due to the use of cheaper components and pricing policy pharmacy network.

Read the official information about the drug Caffeine sodium benzoate, instructions for use of which include general information and treatment plan. The text is provided for informational purposes only and cannot serve as a substitute for medical advice.

Caffeine sodium benzoate is a nervous system stimulant.

pharmachologic effect

Caffeine sodium benzoate has a direct stimulating effect on the cerebral cortex, stimulates the work of the respiratory, vasomotor centers of the medulla oblongata, strengthens reflexes, ensures interneuronal conduction in the spinal cord, increases motor activity, activates mental activity, eliminates drowsiness, and helps cope with fatigue.

The drug in small doses stimulates the nervous system, and in high doses may be harmful - sodium benzoate with caffeine can have a depressant effect on the nervous system.

Under the influence of cardiac and vascular mechanisms the influence of caffeine changes blood pressure: if the pressure is normal, the drug increases it slightly or does not affect it at all, and if the pressure is low, caffeine increases it.

It was also noted that caffeine stimulates the production of gastric juice, has a diuretic effect, and reduces platelet aggregation.

Release form

Caffeine sodium benzoate tablets are produced.

Indications for use

According to the instructions, sodium benzoate is indicated for: increased sleepiness, headaches caused vascular pathologies, incl. migraines, moderate hypotension, decreased physical and mental performance.

Instructions for use of Caffeine Sodium Benzoate

Caffeine tablets can be taken with or without meals throughout the day. It is better not to take caffeine before bed, because... Insomnia may occur.

To improve performance and eliminate drowsiness in children over 12 years of age. and adults are given 50-100 mg of the drug two or three times a day. Treatment can last several weeks or months.

For the treatment of headaches in children over 12 years of age. and adults are advised to take 50-100 mg of the drug two or three times a day for several days.

For the treatment of unexpressed arterial hypotension Children over 12 years old, adults are prescribed to take 50-100 mg 2-3 times a day. Treatment low blood pressure lasts several weeks.

During therapy, it should be taken into account that the maximum permissible single dosage of sodium benzoate is 300 mg, and the daily dosage is 1000 mg.

Side effects

The harm of sodium benzoate with caffeine is that the drug in case of intolerance or non-compliance medical recommendations may cause anxiety, restlessness, psychomotor agitation, headaches, epileptic seizures, dizziness, tachypnea, insomnia, exacerbation of peptic ulcer, nausea, vomiting, nasal congestion, drug addiction, tachycardia, increased blood pressure.

Sudden caffeine withdrawal may lead to muscle tension, inhibition of the nervous system, increased fatigue, drowsiness.

An overdose of the drug is possible, which is expressed increased anxiety, abdominal pain, confusion, dehydration, arrhythmia, hyperthermia, headaches, agitation, increased urination, trembling, muscle twitching, nausea, vomiting blood, convulsions, ringing in the ears.

The harm of sodium benzoate with caffeine appears already when consumed at a dose of more than 300 mg/day: headaches, tremors, confusion, extrasystole, anxiety may appear.

Overdose is treated by gastric lavage, laxatives, and activated charcoal. If the patient hemorrhagic gastritis, he is administered antacid medications and the stomach is washed with a 0.9% sodium chloride solution, and artificial ventilation is maintained. If convulsions occur during an overdose, diazepam, phenytoin, phenobarbital are administered intravenously, and water-electrolyte balance is maintained.

Contraindications to the use of sodium benzoate

According to the instructions, sodium benzoate is contraindicated in anxiety disorders, cardiovascular diseases of an organic nature, with hypersensitivity to the means paroxysmal tachycardia, ventricular extrasystole, hypertension, sleep disorders, children under 12 years old.

Caffeine sodium benzoate tablets should be prescribed with caution in the elderly, with glaucoma, epilepsy and a tendency to seizures.

Lactating and pregnant women can take caffeine only for special indications.

During treatment, it should be taken into account that simultaneous use caffeine with oral contraceptives, ciprofloxacin, disulfiram, norfloxacin, cimetidine can lead to slow elimination of caffeine by the liver and an increase in its level in the blood. The drug in combination with drinks and medications containing caffeine may cause excessive stimulation of the nervous system.

It should also be taken into account that the substance mexiletine impairs the excretion of caffeine, while nicotine increases it. Caffeine, in turn, worsens the absorption of calcium in the gastrointestinal tract, reduces the effectiveness of sleeping pills and narcotics, accelerates the absorption of cardiac glycosides, and increases the excretion of lithium in the urine.

Sincerely,

The modern rhythm of life requires a person to be completely involved in its whirlpool, which is why so many people desperately lack rest. How to overcome the resulting drowsiness? A cup of aromatic coffee often helps to disperse drowsiness and get into active mode. But this method doesn't always work. Therefore, many people choose an alternative - a drug called “Caffeine”. The instructions for use characterize it as a psychostimulant drug, the effectiveness of which is associated with the alkaloid it contains, produced from tea leaves (2% caffeine), coffee beans (1-2 percent) and cola nuts.

"Caffeine sodium benzoate", which can be found in pharmacies, is synthetic drug, obtained from these compounds.

Pharmacological properties (application)

A methylxanthine derivative, caffeine, has a psychostimulating and analeptic effect on the body. Its main property is the ability to improve motor activity, stimulate positive reflexes and various processes excitations occurring in the cerebral cortex. Thanks to this effect on the body, mental and physical activity, drowsiness disappears, the feeling of fatigue decreases.

Caffeine can also increase blood pressure, but this occurs more often in states of shock or collapse. In small doses, caffeine provides a stimulating effect; in large doses, depression of the nervous system often occurs. What other effects does caffeine have? Instructions for use warn about increased and deepening of breathing when taking the drug, narrowing of blood vessels in the brain and a decrease in oxygen pressure in it. In cases of arterial hypotension, caffeine often normalizes blood pressure. The antispasmodic effect of the alkaloid on smooth muscles, and stimulating - to striated. Under the influence of caffeine, the secretory activity of the stomach increases and the basal metabolism increases (increased glycogenolysis, accelerated lipolysis). Moderate diuretic effect is also a consequence of caffeine consumption.

"Caffeine": indications for use

The drug is prescribed for diseases accompanied by a depressed state of the central nervous system, for disturbances in the functioning of the cardiovascular and respiratory systems (including poisoning with drugs, alcohol and toxins as a result of infectious process), asphyxia, asthenia, enuresis (including in children), migraine, to relieve spasms of cerebral vessels. In ophthalmology, caffeine is used after eye surgery to reduce tone and retinal detachment.

This medicine is also indicated for decreased mental and physical performance, drowsiness, and to restore the optimal level of activity. A stable trend recent years has become an application this drug as a catalyst for the weight loss process. Wherein mandatory conditions are strict adherence to dosage, doctor’s recommendations and physical exercise. In cosmetology, the mixture of “Caffeine-sodium benzoate” and “Capsicam” has proven itself well as effective remedy for anti-cellulite wrap.

Release form

“Caffeine sodium benzonate” (containing up to 40% caffeine) is available in the form of injection solution, tablets and powder (capsules).

Directions for use and dosage

How to take Caffeine correctly? Tablets, the instructions for use of which advise their use orally no more than 2-3 times a day, are prescribed for adults in a single dose of 100-200 mg (no more than 0.4 g) and a daily dose of no more than one gram, for children - according to 25-100 mg. Caffeine ampoules (1 ml) are intended for subcutaneous and subconjunctival administration.

Children are injected subcutaneously with a ten percent caffeine solution of 0.25-1 ml. In ophthalmology, a 10% solution of caffeine in ampoules is also used: no more than 0.3 ml of the drug is dripped under the conjunctiva once a day. The dosage and duration of treatment are prescribed by the doctor and depend on the patient’s condition, as well as the nature of the disease. Caffeine sodium benzoate should not be taken before bed.

Contraindications

The psychostimulant "Caffeine-benzoate" instructions for use do not recommend prescribing to people with arterial hypertension, increased excitability, sleep disturbances (insomnia), those suffering from atherosclerosis, tachycardia, epilepsy, convulsions, increased intraocular pressure (glaucoma). The drug is also contraindicated in children under 12 years of age and people old age. Anti-cellulite masks should not be applied to affected areas of the skin.

Side effects

When taking a drug containing caffeine, the instructions for use advise paying attention to possible negative reactions body: from the central nervous system - anxiety, excitement, tremor, headache, anxiety, convulsions, dizziness, increased muscle tone, increased reflexes, insomnia, tachypnea. If the drug is abruptly discontinued, lethargy, drowsiness, fatigue, and increased inhibition of the central nervous system reaction may occur.

From the cardiovascular system, arrhythmia, tachycardia, and increased blood pressure are possible. From the gastrointestinal tract - nausea, exacerbation of peptic ulcers, vomiting, colic. At long-term use addiction, dependence on the drug is possible due to the formation of new adenosine receptors in the brain cells.

Overdose

What symptoms can excess caffeine cause? Instructions for use warn in such cases about increased severity of side effects: anxiety, confusion, mental and motor agitation, tremor or muscle twitching, epileptic seizures; dehydration, tachycardia, arrhythmia, headache, ringing in the ears, hyperthermia, frequent urination, nausea and vomiting.

The same conditions can occur after taking 300-600 mg (4 cups) of coffee per day, especially if combined with taking Caffeine Sodium Benzoate tablets.

special instructions

During pregnancy and while breastfeeding, caffeine is taken only in cases of extreme necessity and under the supervision of a doctor! Abuse of the drug and drink threatens possible spontaneous abortion, delay intrauterine development, inhibition or disturbances in skeletal development, arrhythmia in the fetus. During the lactation period, caffeine penetrates into breast milk and, accumulating, threatens the baby’s insomnia and hyperactivity.

"Caffeine": instructions for use, price, storage conditions and expiration date

The drug must be stored away from children, out of reach of them, at temperatures up to 25 degrees, for no more than 5 years.

The cost of “Caffeine-sodium benzoate” tablets (6 pieces) in pharmacies today is approximately 32-40 rubles, a package of 10 ampoules (1 ml) of 20% solution is sold for 40-64 rubles.

Analogs

In addition to tablets produced in blisters of 6 or 10 pieces, as well as a solution for injection in ampoules, in pharmacies you can find drugs with various combinations of substances, which include caffeine. What other medications containing caffeine are listed in the instructions for use of medications? Expert reviews call the following analogues: “Askofen” (40 mg) and “Coficil Plus” (50 mg of the substance in question), “Migrenol” and “Solpadeine Fast” - 65 mg each, “Aquacitramon” (45 mg), as well as “Citramon” "and regular "Solpadeine" - 30 mg each. Of the drinks containing this common psychostimulant, reviews on forums mention coffee, tea, hot chocolate and soda (cola). The weight loss product Liquid Chestnut, which contains guaranine (an analogue of caffeine and theine), has a double concentration of caffeine.