What does phenazepam do? Phenazepam tablets - official instructions for use

Our article will review the drug “Phenazepam”, briefly describe its indications and contraindications for use, and also describe in detail cases of overdose of this medicine and the answer is given to the question of what to do if this happens.

What is the drug “Phenazepam”?

The medical drug belong to the group of tranquilizers, that is, drugs that have a pronounced sedative effect. Also, the remedy in question can effectively relieve symptoms such as increased anxiety, fears, worries. Main active component medicine “Phenazepam” is, in fact, the substance phenazepam, also each tablet of the named drug contains auxiliary components: lactose, corn starch, magnesium stearate and silicon dioxide. The drug is available in the form of white tablets, each 1 mg. They are sealed in blisters of 10 pieces. The package itself usually contains 50 tablets.

Indications for use of the drug “Phenazepam”

Please note in what cases this is usually prescribed medicine. Here are some indications for its use:

increased anxiety and irritability, unreasonable fears;
obsessive states;
insomnia;
withdrawal syndrome (withdrawal syndrome) in alcoholism and drug addiction;
psychoses.

In general, the range of use of this medicine is quite wide; it is used both for the treatment of schizophrenia and reactive psychoses, and as an induction of anesthesia before surgery.

The drug “Phenazepam”: contraindications for use, side effects

The drug has an extensive list of contraindications for use. So, it is not used if the patient has following states or diseases:

hypersensitivity to individual components, present in the composition of the drug;
it cannot be used to treat pregnant and lactating women;
persons under 18 years of age;
it is not used to treat severe depression;
as well as myasthenia gravis, coma, shock, closed glaucoma.

Side effects from using this medical product There may be drowsiness, absent-mindedness, increased fatigue And general weakness. From the gastrointestinal tract - constipation or, conversely, diarrhea, vomiting, nausea, various disorders appetite. May also appear skin rashes caused by an allergy to the drug: itching, urticaria, various rashes and redness of the integument.

The drug “Phenazepam”: dosage for different categories of patients

The dosage of this medicine depends on the specific disease or condition diagnosed in the patient. So, adult dose at the beginning of taking the drug is 0.5-1 mg two or three times a day. Average daily dose for adults - 3-5 mg. The final decision about the exact quantities to take the drug must be made by the doctor. When taking Phenazepam, the dose per day should not exceed 10 mg. Moreover, for sleep disorders and insomnia, 250 to 500 mg is usually prescribed, that is, half or a quarter of a tablet half an hour before bedtime. For epilepsy - 2-10 mg per day, for alcohol or drug withdrawal syndrome - 2-5 mg per day. Please keep in mind that this drug is not sold freely in pharmacies; it can only be purchased with a doctor’s prescription.

The drug “Phenazepam”: overdose. What to do if it happens?

Please note that taking large doses this drug may cause loss of coordination, hand tremors, blurred vision and speech, slow breathing and heart rate. Two last symptom are especially dangerous, therefore the drug “Phenazepam”, an overdose of which can also cause coma, should in no case be taken more than 10 mg per day. If it happened that it was accepted once a large number of of this medicine, the person must immediately call ambulance or immediately go to the nearest hospital, and go or go there not alone, but accompanied by someone. Usually in medical institutions To weaken the effect of this medicine, drugs based on the substance strychnine are used. They are injected intramuscularly 2-3 times a day. The patient is also prescribed medications that stimulate the functioning of the lungs and heart. The patient should be observed by a doctor for some time. Please note that alcohol greatly affects the effect of the drug “Phenazepam”; an overdose in such cases can occur, even if you have taken the recommended dose of the drug. The thing is that ethanol enhances the suppressive effect of the drug, and also makes toxic and other reactions more likely. side effects from taking it. Therefore, be careful; when treating with Phenazepam, alcohol is contraindicated throughout the entire course of use of the drug.

Conclusions and Conclusion

In general, the drug in question is very famous medicine, it has been used to treat patients for decades. It is quite effective and correct dosage does not cause any special side effects, except drowsiness. But it is impossible to say at what exact quantity of a single dose pronounced unwanted effects from the drug “Phenazepam”. An overdose is possible within the recommended 10 mg if you take the drug with alcohol. Also, its effect depends on the age, health and weight of the patient. Therefore, do not take this medicine under any circumstances without a doctor’s recommendation, and strictly follow its instructions. Typically, doctors calculate a single dose depending on the patient’s complaints, as well as many other factors. Self-medication in this case can be life-threatening.

Phenazepam is a “complex” drug that must be taken with caution. It is undesirable to exceed the recommended dosages of phenazepam, so as not to provoke poisoning, side effects, addiction and drug dependence.

Doses of phenazepam according to instructions

We will talk about tablets, since the drug in ampoules is used only in medical institutions. In an informational article for a wide range of readers, such diversions would be inappropriate.

For insomnia, the drug is prescribed in a dose of 0.5 mg 40-60 minutes before bedtime;

Neuroses and psychoses require the drug to be prescribed in a dosage of 0.5-1 mg 2-3 times a day. Depending on the effect, it may be increased;

For fear and anxiety (which can also be accompanied by sleep disturbances), the daily dose of phenazepam for a person is 3 mg, followed by an increase;

Treatment of epilepsy and withdrawal syndrome requires even higher dosages;

Maximum dose phenazepam per day – 10 mg.

What affects the dose of the drug?

If you read the instructions for the drug, you will understand why it is worth limiting the dosage of sleeping pills. It has a lot of negative side effects and contraindications, it is addictive and addictive. But what if usual dose Doesn't taking phenazepam work?

Decide why this is happening.

1. Different people have different sensitivity to the drug.

Its effectiveness does not depend on body weight or age, it’s all about sensitivity to active substance. Sometimes it happens that a person with insomnia is not affected by the dosage prescribed by the doctor. This is usually noticeable from the very beginning of treatment.

2. Over time, addiction develops.

Another situation: at first phenazepam helped, but then stopped. The body begins to require a larger dose of phenazepam in order to have any effect! When taking pills regularly, addiction inevitably occurs. The sensitivity of the receptors that perceive the drug decreases, and the effect standard doses Same.

How to choose a dose so that there are no consequences

1. Take this medication only as directed by your doctor.

Hopefully you know this by default. Only a doctor understands all the details of your condition, knows what initial dose to prescribe, whether it should be increased and by how much.

2. Increase the dosage gradually.

If a person takes phenazepam for insomnia, he should not have this situation: he took a pill, did not see the effect, took one or two more. The dosage is increased according to the doctor’s recommendation and gradually, not abruptly!

3. You cannot take phenazepam constantly.

The permissible duration of treatment is 2 weeks. IN in rare cases the reception is longer. But it is optimal to take any sleeping pill as needed (occasionally) and no more than 8 times a month.

If you feel that you will fall asleep on your own, you should not take phenazepam as a means of preventing insomnia. Try to restrain yourself! This will slow down the decrease in sensitivity to the drug and prevent addiction from developing.

4. Be prepared to stop taking the drug.

There is no need to get attached to pills. You should not allow yourself to believe that they are necessary for your sleep, and without them you will not fall asleep. It is easy to develop dependence on phenazepam; there is no need to encourage it with constant replenishment of supplies, and there is no need to keep the drug on the nightstand all the time. Think of it simply as a temporary relief from which you can move away at any time.

5. Make sure it is phenazepam you need.

Many people take the drug without indications. Especially those who use it for sleep. It must be remembered that sleeping pills do not fight the cause of insomnia, which means they simply suppress the symptom, but do not eliminate the problem.

The only drug that eliminates the cause of insomnia is Melaxen. It contains the sleep hormone melatonin, helps restore sleep and restore rhythms in circadian insomnia (sleep disorders caused by improper sleep patterns).

The drug is very effective for insomnia due to shift schedule, jet lag or sleep disturbances on weekends. It helps from the first days, is not addictive or dependent, and is sold in pharmacies without a prescription.

Make an appointment with a somnologist

Phenazepam is the first one that was developed by Soviet pharmacists. Its task is to influence the central nervous system to help it cope with various critical situations. Phenazepam relieves any emotional stress, be it fear, panic or anxiety, depression or depression. It is able to put a person to sleep or reduce the degree of irritability, relax the body muscles and neutralize cramps.

However, this medicine can negatively affect a person’s memory, as well as cause a number of other side effects, so before taking it, you need to understand how Phenazepam works.

Effect of the drug

The action of Phenazepam is due to the work of the main substance of the same name, which depresses the nervous system, suppresses nerve impulses, inhibits physical and emotional reactions to stimuli external environment. As a result, the person regains emotional balance and deep sleep.

The drug is taken orally in the form of tablets, and is also administered intramuscularly - by injection, and intravenously - through droppers. Phenazepam begins to act approximately 30 minutes after administration, but it will take quite a long time to be eliminated from the body - within several days.

Indications for use of Phenazepam

Phenazepam is believed to be very popular among drug addicts due to its relaxing properties. Doctors confirm that the drug is indeed included in the group narcotic substances and may be harmful if taken inappropriately medical indications and in violation of dosage standards. Meanwhile, there are clear instructions on what Phenazepam helps with.

This medicine is indicated for the following psycho- and physiological problems:

problems falling asleep, as well as restless, interrupted sleep;
suspiciousness, including in relation to the state of one’s health, expressed to an extreme degree;
unstable mood for no apparent reason, irritability, anxiety, unreasonable fear, phobias, psychoses and other neurotic conditions;
nervous tics and movements;
various types of disorders associated with alcohol withdrawal.

Doctors also traditionally prescribe Phenazepam for depression and other mental disorders.

Consequences of using Phenazepam

Phenazepam is a drug strong action. Its dosage, as well as the duration of use, must be strictly controlled, otherwise the consequences of using Phenazepam will affect both physical and mental health. psychological state patient. However, even with strict adherence medical recommendations People taking Phenazepam may experience unhealthy symptoms such as:

drowsiness;
hallucinations;
inhibition of reactions;
substitution of emotions - from positive to initial stage taking the drug until negative in the future;
thoughts about suicide;
memory impairment;
addiction, developing into addiction, against the background of which nervous disorders can occur.

It turns out that the incorrect use of Phenazepam will lead to consequences that the patient wanted to get rid of at one time. That is, what Phenazepam affects, it can both cure and destroy new strength. The task of doctors and the patient is not to fall into this vicious circle.

Attention! We must not forget about serious consequences taking medication in the form of fatal outcome, which is possible if you combine it with alcohol.

If the patient nevertheless violates the regimen, and the body becomes accustomed to Phenazepam, then it is recommended to discontinue the drug in inpatient conditions under medical supervision.

Side effects from taking Phenazepam

The side effects of Phenazepam are quite unpredictable. The likelihood and degree of their manifestation are individual and depend on the neuropsychological state of each patient. On the list negative reactions organisms are:

decreased concentration of attention coupled with drowsiness;
headache;
muscle weakness;
confused consciousness and disorientation in space;
low blood clotting;
dry mouth;
nausea and loss of appetite;
diarrhea or constipation;
skin rashes;
problems with the liver and kidneys;
increase in body temperature.

Important! An overdose of the drug leads to disturbances in speech, motor, respiratory and muscle functions.

Contraindications for the use of Phenazepam

Due to the fact that the drug is classified as a potent drug, it is not suitable for all patients. Phenazepam contraindications:

pregnancy and lactation;
age – up to 18 years;
muscle weakness;
high intraocular pressure;
chronic lung diseases;
shock or coma;
individual intolerance to the drug.

It is recommended to prescribe the drug very carefully to older people. Reviews about the use of the medicine are contradictory. Among the advantages is its affordable price, among the disadvantages are the risk of addiction and an inhibited state during treatment. Your doctor will tell you how to take Phenazepam correctly and whether it’s worth it. Self-medication is unacceptable, as it can lead to negative consequences for good health.

The page contains instructions for use Phenazepam. It is available in various dosage forms drug (tablets 0.5 mg, 1 mg and 2.5 mg), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on the use of Phenazepam, which will help other site visitors. The drug is used for various diseases(neurosis, psychosis, epilepsy). The product has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment with Phenazepam can only be prescribed by a qualified doctor. The duration of therapy may vary and depends on specific disease. Interaction of the drug with alcohol and control of dispensing from pharmacies (with or without a prescription).

Instructions for use and dosage regimen

The drug is prescribed orally.

A single dose of Phenazepam is usually 0.5-1 mg, and for sleep disorders - 0.25-0.5 mg 20-30 minutes before bedtime.

For the treatment of neurotic, psychopathic, neurosis-like and psychopath-like conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 4-6 mg per day, the morning and afternoon dose is 0.5-1 mg, at night - 2.5 mg.

For severe agitation, fear, anxiety, treatment begins with a dose of 3 mg per day, quickly increasing the dose until therapeutic effect.

When treating epilepsy, the dose is 2-10 mg per day.

For treatment alcohol withdrawal prescribed at a dose of 2.5-5 mg per day.

IN neurological practice for diseases with increased muscle tone the drug is prescribed 2-3 mg 1 or 2 times a day.

The average daily dose of Phenazepam is 1.5-5 mg, divided into 3 or 2 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. The maximum daily dose is 10 mg.

To avoid development drug addiction, at course treatment The duration of use of phenazepam, like other benzodiazepines, is 2 weeks. But in some cases, the duration of treatment can be increased to 2 months. When discontinuing the drug, the dose is reduced gradually.

Release forms

Tablets 0.5 mg, 1 mg and 2.5 mg.

Solution for injection 1 mg/ml.

Phenazepam- has a pronounced anxiolytic, anticonvulsant, central muscle relaxant and hypnotic effect.

It enhances the inhibitory effect of GABA in the central nervous system by increasing the sensitivity of GABA receptors to the mediator as a result of stimulation of benzodiazepine receptors, reduces the excitability of subcortical structures of the brain, and inhibits polysynaptic spinal reflexes.

Pharmacokinetics

When taken orally, the drug is well absorbed from the gastrointestinal tract. Metabolized in the liver. The drug is excreted mainly through the kidneys.

Indications

for various neurotic, neurosis-like psychopathic, psychopathic and other conditions accompanied by anxiety, fear, increased irritability, tension, emotional lability;
with reactive psychoses;
with hypochondriacal-senesopathic syndrome (including those resistant to the action of other tranquilizers);
at autonomic dysfunctions and sleep disorders;
for the prevention of states of fear and emotional stress;
How anticonvulsant the drug is used to treat patients with temporal lobe and myoclonic epilepsy;
In neurological practice, phenazepam is used to treat hyperkinesis and tics, muscle rigidity, and autonomic lability.

Contraindications

myasthenia gravis;
severe dysfunction of the liver and kidneys;
tranquilizer poisoning, antipsychotics(neuroleptics), sleeping pills, drugs, ethyl alcohol;
pregnancy;
lactation period.

With caution - old age.

special instructions

The drug should be used with caution in elderly and debilitated patients.

Frequency and character side effect depend on individual sensitivity, dose and duration of treatment. When you reduce the dose or stop taking phenazepam, the side effects disappear.

Similar to other benzodiazepines. has the ability to cause drug dependence when long-term use in large doses (more than 4 mg per day). If you suddenly stop taking it, withdrawal syndrome may occur (depression, irritability, insomnia, increased sweating), especially with long-term use (more than 8-12 weeks).

The drug enhances the effect of alcohol, so drinking alcohol during treatment with phenazepam is not recommended.

Impact on the ability to drive vehicles and operate machinery

Phenazepam is contraindicated during work for transport drivers and other persons performing work that requires quick reactions and precise movements.

Side effect

impaired memory, concentration, coordination of movements (especially at high doses);
drowsiness;
muscle weakness;
ataxia;
possible paradoxical arousal;
dizziness, headache;
dry mouth;
nausea;
diarrhea;
menstrual irregularities;
decreased libido;
dysuria;
addiction (drug dependence);
skin rash, itching.

Drug interactions

Phenazepam is compatible with other drugs that cause depression of the central nervous system (hypnotics, anticonvulsants, antipsychotics), however complex application it is necessary to take into account the mutual strengthening of their action.

Reduces the effectiveness of levodopa in patients with parkinsonism.

May increase the toxicity of zidovudine.

Microsomal oxidation inhibitors increase the risk of toxic effects.

Increases the concentration of imipramine in the blood serum.

Antihypertensive drugs may increase the severity of the decrease in blood pressure.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Analogs medicinal product Phenazepam

Structural analogues of the active substance:

Tranquesipam;
Fezanef;
Fesipam;
Phenorelaxan;
Elzepam.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

Instructions for use:

pharmachologic effect

Phenazepam is a highly active tranquilizer, has anxiolytic, anticonvulsant, central muscle relaxant and sedative effect. The tranquilizing and anti-anxiety effect is superior in strength to the analogues of Phenazepam. The drug also has anticonvulsant and hypnotic effect. The anxiolytic effect of the drug is expressed in reducing emotional stress, easing fear, anxiety and restlessness.

According to the reviews received, Phenazepam has virtually no effect on affective, hallucinatory and acute delusional disorders.

Phenazepam dosage and instructions for use

Intramuscularly and intravenously: for rapid relief of psychomotor agitation, anxiety, fear, as well as in psychotic states and vegetative paroxysms - an initial dose of up to 1 mg, average dose per day – 3-5 mg, maximum – 7-9 mg.

Oral administration: for sleep disorders, from 250 to 500 mcg, 20-30 minutes before bedtime. When treating psychopathic, neurotic, psycho-like and neurosis-like conditions, the first dose is up to 1 mg, 2-3 times a day. The dosage can be increased after 2-4 days, if available. positive effect, up to 4-6 mg per day. For severe fear, agitation, and anxiety, the first dose is 3 mg per day, with a rapid increase until a therapeutic effect is achieved. For the treatment of epilepsy, 2-10 mg per day. For the treatment of diseases with muscle hypertonicity, take 2-3 mg of the drug 1-2 times a day. The maximum dose is 10 mg/day.

To avoid becoming dependent on Phenazepam, the instructions recommend that the course of therapy should not last more than two weeks. In exceptional cases, it is possible to increase the duration of the course to 2 months. The dosage reduction should occur gradually.

Indications for use of Phenazepam

Phenazepam is indicated for neurotic, neurosis-like, psychopathic and psycho-like conditions. For reactive psychoses, senesto-hypochondriacal disorders, insomnia, alcoholism, substance abuse, status epilepticus, epileptic seizures.

For the treatment of muscle rigidity, hyperkinesis, athetosis, tics, autonomic lability.

Contraindications to the use of Phenazepam

coma;
myasthenia gravis;
severe form of depression;
angle-closure glaucoma;
analgesic poisoning or acute poisoning alcohol;
acute respiratory failure;
I trimester of pregnancy;
children under 18 years of age;
during lactation;
intolerance to benzodiazepines.

special instructions

Caution is required when using Phenazepam in patients with hepatic or renal failure, persons prone to abuse psychoactive substances, with organic brain damage, in elderly patients.

Like its analogues, Phenazepam can cause drug dependence when long-term therapy large doses. When carrying out treatment with Phenazepam, the use of ethanol is strictly prohibited. There are no reviews on the treatment of persons under 18 years of age with Phenazepam; the effectiveness and safety of the drug have not been established. Phenazepam affects concentration, so special care is required when driving for persons receiving treatment with Phenazepam.

Overdose of Phenazepam

Symptoms of Phenazepam overdose: decreased reflexes, drowsiness, tremor, nystagmus, prolonged dysarthria, shortness of breath or difficulty breathing, bradycardia, coma, decreased blood pressure.

Interaction of Phenazepam with other drugs

According to reviews, Phenazepam reduces the effectiveness of levodopa in patients with Parkinson's disease. Phenazepam increases the toxicity of zidovudine.

A mutual enhancement of the effect was noted when combined with antipsychotic, antiepileptic and sleeping pills, and also with central muscle relaxants, narcotic analgesics and ethanol.

When combined with antihypertensive drugs, their effect may be enhanced. At simultaneous administration clozapine may cause respiratory depression.

Pregnancy and lactation

The use of Phenazepam by pregnant women is permissible only according to vital signs. The drug has toxic effects on the fetus, increasing the risk of development birth defects, when used in the 1st trimester of pregnancy. Use of Phenazepam for more than later causes central depression in the newborn nervous system. Regular use during pregnancy may develop dependence and withdrawal symptoms in the newborn.

The use of Phenazepam during childbirth, or immediately before it, can cause the appearance in a newborn of: depressed breathing, hypothermia and hypotension.

Side effects of Phenazepam

From the central and peripheral nervous system: in the first days of treatment (especially in elderly patients) - a feeling of fatigue, confusion, drowsiness, dizziness, ataxia, decreased concentration, disorientation, slow reactions; rarely - depression, euphoria, headache, tremor, loss of coordination, memory impairment, uncontrolled movements, asthenia, dysarthria, myasthenia, epileptic seizures(in patients with epilepsy); extremely rarely – aggressive outbursts, fear, psychomotor agitation, suicidal tendencies, muscle spasms, hallucinations, irritability, agitation, insomnia, anxiety.

From the circulatory system: leukopenia, agranulocytosis, neutropenia, thrombocytopenia, anemia.

From the outside digestive system: heartburn, vomiting, diarrhea or constipation.

Possible allergic reactions in the form of itching or skin rash.

Others possible reactions: like its analogues, Phenazepam causes drug dependence and a decrease in blood pressure; rarely - visual impairment, tachycardia. With abrupt withdrawal or dose reduction, withdrawal syndrome occurs.