Mexidol before or after meals. Don't worry, it won't hurt

Read the instructions, everything is written there

Disadvantages The drug did not help. Mexidol was prescribed to our family members more than once. Once upon a time, a long time ago, it was prescribed to an elderly father suffering from cerebral atherosclerosis.

Like prin. Mexidol (before, during or after meals)? Is it possible to take it? simultaneously with Tanakan? Are there better drugs? Which ones?

Method of administration and dose: IM or IV (stream or drip). When administered by infusion, the drug should be diluted in an isotonic sodium chloride solution.
Doses are selected individually depending on the pathology and severity of the patient's condition.
The recommended dose is 5-10 mg/kg/day, depending on the condition.
Mexidol is injected slowly over 1-3 minutes, dropwise at a rate of 40-60 drops per minute.
In the treatment of acute cerebrovascular accident, Mexidol is used intravenously in drops from 100 to 1000 mg/day, depending on the severity of the condition, for 10-14 days (the daily dose is divided into 2-4 administrations), then intravenously in a stream or i.v. m 200 mg 2 times a day for another 10-14 days.
For acute traumatic brain injury, Mexidol is administered intravenously at a dose of 100-1000 mg/day, depending on the severity of the injury and the patient’s condition. The daily dose is divided into 2-4 injections.
For encephalopathies in the decompensation phase, Mexidol is used intravenously in a stream or drip at a dose of 200-300 mg 2-3 times a day for 10-14 days, then intramuscularly at 200-300 mg/day for 10-14 days.
For course prophylaxis for encephalopathies of various origins, Mexidol is administered intramuscularly at a dose of 200 mg 1-2 times a day for 10-14 days. In the future, they switch to using it in tablet form.
For vertebrobasilar insufficiency in the decompensation phase, Mexidol is administered 200 mg 2-3 times a day intravenously or intravenously, for 10-15 days; in the subcompensation phase - 200 mg 1-2 times a day intravenously or intramuscularly for 10-14 days with a further transition to the tablet form; in the compensation phase (preventive course) - 100-200 mg (1-2 amp.) IM daily for 10-15 days or in tablet form.
Epilepsy and episyndromes: 200-400 mg 1-2 times a day intravenously for 10-15 days, followed by transition to long-term oral administration.
For cognitive disorders of atherosclerotic origin in elderly patients, neurotic and psychoorganic syndromes - IM at a dose of 100-300 mg/day for 14-30 days, followed by switching to tablet form.
For alcohol and drug intoxication - IV drip at a dose of 300-400 mg 2-3 times a day until the intoxication is relieved.
For withdrawal syndromes (alcohol and drugs) - at a dose of 200-300 mg intravenously or intramuscularly 2 times a day for 5-7 days.
In case of acute intoxication antipsychotics- IV drip, in a daily dose of 400-800 mg, divided into 2 injections.
For asthenic disorders - at a dose of 100-200 mg/day IM daily for 10-15 days. Then they switch to tablet form.
In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), Mexidol is prescribed on the first day both in the preoperative and postoperative periods. The dose of the drug depends on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. For acute edematous (interstitial) pancreatitis - 200-600 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis of mild severity - 200-400 mg 2-3 times a day intravenously and intramuscularly. For necrotizing pancreatitis of moderate severity - 200-600 mg 2-3 times a day intravenously; in case of severe course of the process - on the first day, a pulse dose of 800 mg is prescribed, divided into 2 injections, then 300 mg 2 times a day with gradual decline daily dose. In case of extremely severe necrotizing pancreatitis, the initial dose is 800 mg/day until the manifestations of pancreatogenic shock are persistently relieved, when the condition stabilizes - 300-400 mg 2 times a day intravenously, with a gradual reduction in the daily dose.
Course therapy with Mexidol is completed gradually, reducing the dose of the drug over 2-3 days.

The medical drug Mexidol was developed in Russia and is part of the group of nootropic drugs that improves metabolism in the brain. Acts directly on brain cells, Mexidol protects them from oxygen starvation and protects them from death as a result of ischemia.

Mexidol is a good drug (another similar drug is Actovegin, about the same level). You can take it with tanakan. Take regardless of food.

Please tell me how to take Mexidol: before meals, after or during meals

How to drink Mexidol tablets correctly (before, after or regardless of food)? (specify the source)

This is indifference to one end....

Mexidol improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation.

Sveta, did you read the summary? There is a phrase there: “It is possible that individual adverse reactions dyspeptic or dyspeptic nature." Hence the conclusion. Eat Mexidol after meals. About two hours later.

Doctors need advice. What should be used first, Mexidol or Gliatilin. Or can it be used simultaneously? Thank you

WHAT SHOULD I DO? I CAN NOT TAKE IT ANYMORE.

Go tell this to your district military officer))))))

The manufacturer also stated that Mexidol improves blood fluidity, which improves blood circulation in the smallest vessels, and hence the nutrition of tissues, including brain neurons

Are you 23 years old? You write well. Have you tried writing books?

Look for an adequate psychotherapist. No kidding.

Just based on teenage maximalism, hormonal changes and 100 percent of a bad example - you suffered so much. happens to many people. will pass. don't get carried away.

Follow a warm diet. You can only eat warm food and drink only warm food. If you eat or drink something cold, then in three days illnesses will begin.
Sugar and sweets are not allowed.
Every day you need to read the book Medical Encyclopedia

Kvelo made it up.

Please tell me how to take nootropil before or after meals? Or is this not so significant? Not the best choice, although it is often prescribed. For me, Cortexin, Mexidol, Cavinton, Mildronate are the best medicines for VSD. Everything is in droppers in...

You should stop jerking off when you're 15, Danya. Masturbation has such an effect on the psyche. Give it up and everything will return to normal in a couple of months.

Well, if seriously you will no longer be the same, I know good advice for you, come to God, learn to pray, look for only the good in everything, even if it is bad, with a good intention in everything and the main thing is to understand that everything does not happen quickly, you need to sincerely want it, even if it seems to you that you you sincerely want to recover and nothing works out, this means you are at the testing stage, you need a lot of patience and will, and the sooner you turn to God, the sooner everything will work out for you, because you only have 15 years so much time to fix everything....

Fight! Read articles on the Internet about your ailments and treatment methods are also indicated there. You just need to read a lot medical literature. But doctors can only do tomography or x-rays, they really can’t do anything else. And think less about your sores, go in for sports, sports have pulled out the wrong kind from any swamp.

You can do sports + be sure to find yourself a hobby that would involve you completely, so that there is no time left for stupid things... stupid thoughts all come from idleness, the brain is not busy... And start reading. Try it with the Bible.

Go to the priest and tell him, he will explain to you what it is and what to do

The drug Mexidol is an effective antioxidant that can improve brain metabolism and blood supply to the brain. The medicine relieves withdrawal symptoms and helps with acute purulent inflammation of the abdominal cavity.

They finished you off with pills. For angina, they are not needed at all and hardening would be necessary. But the fact that the heart as a consequence frequent illness They also began to treat sore throat with pills - this is a complete mess... There is a way out, but it’s not for everyone

News healthy image life and not swallow tons of all kinds of medicines

The main thing is not to hang your nose. Find yourself a hobby, new friends, go for a walk :) Thoughts are material, you will think that everything is so bad - so it will be. Watch the movie "The Secret", it's very motivating.

Orientation cannot change against the background of tablets
try to return to your previous lifestyle, adjusted for healthy habits, and the psyche will gradually recover.
It’s not for me to say that any disruptions are contraindicated for you (alcohol, drugs or other psychotropics). try to concentrate on a specific activity - crossword puzzles, for example
It seems to me that the whole problem is that the therapy was carried out incorrectly, and its abrupt cancellation caused an increase in problems, therefore more healthy eating. You can take Glycine - a harmless remedy that helps the brain quite well (because of it they say that eating nuts is healthy).
And don’t worry about appearance at all. all people are ugly in their own way.

So that's it. Your heartbeat has increased because your immunity has dropped significantly - weakness of the whole body has arisen, and your heart began to perceive any load as if you were lifting an elephant. Yours say the same thing frequent colds. Then your body underwent a restructuring under the influence of hormones - and perhaps you turned to the heart specialist in vain. Panic, a feeling of unreality - these are clinical signs of panic attacks, possibly VSD. In such situations, a psychologist will not help. Only a psychiatrist can help (don’t be afraid of this) or you yourself. You are not yet at the last stage - further phobias may arise, because of which you will be afraid to leave the house, for example.

Food and drinks. Law. Health. The drugs Mexicor and Mexidol perfectly fit this definition. What's the difference? Where are medicines produced?

Drink natural water propolis - your immunity will increase. drink 200 grams of bee bread. - you will develop harmoniously. LOVE BEE PRODUCTS - YOU WILL NEVER BE SICK.

Don't whine, but lead a healthy lifestyle!

This is called adolescence and male maturation. We need to play more sports and find an interesting hobby! And everything will get better!

Transitional age. Think less.

Mexidol was prescribed, 1 tab 3 times a day. I took it for two days, I felt relief immediately, I stopped feeling dizzy and had headaches, my mood improved, my blood pressure dropped. A very good drug. I take it with meals...

You definitely need to see a psychotherapist

Sleep at 21.00 - get up at 7 am. Read the Gospel of Matthew - many wise things are said there.
From the age of 15, I often suffered from tonsillitis - it caused a complication on the heart - release from the army (a dubious plus). At 30 years old - panic attacks = VSD. At 31 I went and took communion - 2 years without pills. Although recently I walked around in just a shirt when everyone was wearing coats and sweaters—I was sick with ARVI for a week. (I shouldn't have been proud)

There is no need to take everything to heart, this is so that mental pathology does not arise. At your place weak immunity, go in for sports, drink tea from mint, chamomile, various medicinal herbs, everything else is the consequences of puberty, because of the violent hormonal levels you have such a mess in your head. Sit down, relax, think about what you want in life, develop a plan on how to achieve it all, motivate yourself, and you won’t notice the rest... you have it ideal age to improve health and everything else too!!! The main thing is not to panic, make friends with yourself, and of course, if you realize that you can’t cope on your own, go to a psychologist, he will guide you..

The heart most likely gave in to a sore throat. Sometimes you need to be examined by a cardiologist. Everything else is a transitional age, find something you like, maybe it’s sports, travel, outdoor recreation, photography, there are many interests, the main thing is to find something
which is actually interesting. Everything will get better soon, think about the good, only the good. Good luck to you.

The best option is self-analysis to begin with. And then, you can turn to science; clearly this is the case, your energy field is probably disturbed. he was well beaten by something very strong. These stresses also say a lot. For some reason I think that this is exactly the issue.

The drug Mexidol belongs to the group of antioxidants and is a round, biconvex tablet of white or slightly cream color. Mexidol tablets are supplied in blister packs of 10 pieces...

The pills could have had an effect on your head, but it’s already gone for you, and now you’ve just gone off the rails. You need to find a hobby or a job and get rid of the nonsense from your head. Otherwise you'll go crazy.

Weren't the pills hormonal?

Hello Danil,
The most important thing (I think) is not to paint yourself into a corner. Fear and stress aggravate the condition and literally paralyze the body, mind and soul. Relax and let go of all your fears and speculations.
Transition and changes in the hormonal system are often accompanied by physical and mental crises. This happens to everyone, only it is expressed in varying degrees. We are all different and each body reacts to changes in its own way. As for heart failure, this also occurs quite often in young people and goes away on its own or with the help of medications. Nothing wrong with that. You just need to try not to add fuel to the fire by making any hasty conclusions and attributing to yourself one or another orientation. It's not time yet! Relax and wait out this period. I liked someone’s advice: “try to look for the good in everything.” Will you do this with the help of turning to God, autotraining, or awareness/admiration of nature and simply rejoice in the fact that you live, breathe, walk - it’s up to you to choose. You need to remember 2 things: everything that is not done is for the better, and everything is good in moderation. Avoid sects and all kinds of extreme trends. So as not to interfere bad thoughts It’s good to get involved in sports, but it’s even better to accustom yourself to doing exercises every day in the morning for 10 minutes is more than enough (but EVERY DAY). You will develop willpower and gain self-confidence. Take care of yourself! Only when you learn to love yourself, respect yourself, make yourself happy. You will be able to meet another person and have the best relationship in the world. Everything will be but not immediately. I wish you patience and good luck.

And this is the future defender of the Fatherland, husband and father of the family.... Fuck...

Well, if from a medical point of view, “I’ll say it as a doctor.” The same panacea is sports, diet, vitamins and normal sleep. Everyone goes through adolescence in their own way. And at this time, no current appears for anyone.
p/s No need to get angry because “I have a headache.” And go to doctors less, because 60% are of little use, or even worse. Well, if you want to use their services, then go to at least 3 and choose the middle one.

Afobazole is not toxic drug. Afobazole is taken orally after meals. What contraindications does Afobazole have? Mexidol slows down free radical processes. Mexidol helps increase the body's resistance to hypoxia, has an anti-anxiety...

I tried this and it turned out, imagine a pulp fiction movie in a goblin translation

Danil, accept Islam. Everything will be fine for you.
http://www.whyislam.ru/

Start looking for Jesus Christ, He will help. I had the same thing and even worse.

This is a side effect of the pills.

Life does not stand still, everything is in motion, everything changes, both us and the world! “Stop a moment, you are wonderful!” - this is only in fairy tales. You set yourself an impossible task and are upset that you cannot complete it. To bring back the past, to return to the past, to be like in the past is again from the “fantasy” series. This is not only not possible, but also unnecessary, it contradicts the laws of nature. Imagine this situation using the example of a street, city, country, science, art, weather, climate, trip, celebration, etc. nothing goes in the opposite direction, only forward. Beautiful moments remain in our memory, in photos and videos, and thus, according to our desire, the past is always with us. Each age period opens up new opportunities for us and covers up the old ones, and this is normal.. You will be 20, 30 and 50, and every time you will go into stress, that you cannot lose a dozen, or even two years, that your strength is not the same, your eyes are not so sharp, etc. and you won’t see what life has given you at the moment..
It might have been good to be carried in a stroller, but you couldn’t do anything on your own.. Transitional age accompanies us from infancy, first at 1.5 years, then at 3, then 5-7 years, etc. but we don’t remember it, or maybe we remember certain moments when we wanted to insist on our own...
In general, everything is fine, you are normal... and don’t get carried away with pills, because this chemistry
They can prescribe to patients both as a medicine and in the form of testing, and for economic purposes, they say, the young body will withstand it, maybe it will go away on its own, but let him think that the pills.. Roulette!! If we get lucky!

Mexidol helps with headaches and dizziness. It normalizes blood pressure, improves blood circulation, and relieves many unpleasant sensations. Dizziness after eating.

Run in the morning

Direct road to the army, to intelligence. There you have to sit in one place for hours, no special loads are expected.

Don't eat sugar.

Gym, football, studying, if you have a lot of thoughts, then there is nothing to do, and you are unlikely to experience childhood carefreeness, it’s just a transition to adulthood

It’s just a transitional age, everything will pass, everyone just goes through it differently

Description of the drug Mexidol, reviews about this drug, the opportunity to discuss its effect on the forum, where all side effects, contraindications and instructions for using the drug Actovegin are discussed.

You won’t believe it... all this kind of bullshit happens even at 27... everything seems to be fine... I have a job, I have money, but I’m still depressed. husband, family, children... everything is fine... but bullshit creeps into my head, and as you rightly said, it’s a complete mess... I’ve been struggling with apathy for six months now - a terrible disease... and no amount of self-hypnosis helps, because you understand that everything is fine, that’s how it is, life is good, and life is good, but the brain doesn’t work except for self-flagellation and awareness of the meaninglessness of life... It helped me to abstract myself from all matters, no matter how important they are... give the opportunity to rest for 3-4 days, if possible, leave the house as little as possible, communicate with people less during this time, do not oblige yourself to do anything, relax, watch your favorite TV series, read, play, the main thing is to get a good night’s sleep, and during the breaks of doing nothing, imagine something you want from several dozen of your life years - the years are very fleeting.... sooooo... it seems to me that I myself was 15, and already 27, 2nd children, second marriage and all that)) horror... you don’t have time to live. .. so think about how you want to see yourself in 5 years, and in 15... draw a clear image of yourself in your head, what you want to be and what you could do for this... and then slowly come out of suspended animation - do it one thing a day, even if it’s small, but necessary to achieve your ideal self... no matter how thin, fat, pumped up, straight or bi, brunette or red... you are unique! love yourself! you are given so little time to enjoy this world... just a few hours... it’s rightly said - you cannot change two dates - the date of birth and the date of death, the rest is in your hands. feel that you have already become the way you want to see yourself... and now go and prove to the whole world that you are exactly that - a musician, a singer or the best welder at a factory... and also on a physiological level, nootropic drugs help well - from light, inexpensive and available - this is piracetam - it makes the brain work, makes you act, removes outbreaks of depression... just take it strictly according to the instructions, according to age - there will be no overdose, but diarrhea is quite)) don’t be discouraged - there is still so much waiting for you - good and bad -get a thrill from everything - even from your depression - everything will pass, everything will change an impossible number of times... and in a year you will regret something that you didn’t start now... and in a year you will be so funny at yourself that you were worried about something, regretted... you are looking within yourself, digging, which means you are growing... it’s great... life is like a complex puzzle and it’s so wonderful to watch how it comes together into a picture - that’s it, and this is here - some are trying to harm, some are helping, some are hypocrites, some are sincere. .. Feel life! To do this, you don’t have to jump from a parachute, write a hit song or hang out at discos... like the “secret” was - if you feel happiness from a sausage sandwich, eat it... live, enjoy! love yourself! everything will pass... I’m finally able to set myself up, although I was already thinking about going to bed... so don’t give up, everything is gradual, bit by bit, bit by bit... if you’re interested in chatting with an over-aged woman, find VK Comme il faut Maine Coon (people, Novokuznetsk)

Also only at 14 years old

So many letters. this is called adolescence, everyone goes through it

Everything will pass - everything will be fine.

We worked with my grandfather a lot: speech therapists, proper nutrition, exercise therapy and medications. As for the medications, I remember the doctor prescribed Mexidol for him. I took it as prescribed and at the beginning of the meal. Therefore, a link to an incorrect technique does not work.

Open up!

Look at your email, I wrote something to you there.
1. the most important thing in your life is that you are alive. loved ones are alive. Everything else can be adjusted. Remember once and for all - your most important treasure is yourself, and not whether someone likes your appearance, what orientation - this is all crap, you can always find the right environment and friends.
2. To calm down, you need to figure everything out for yourself. Now I’ll try to give a couple of tips and important comments.
Anxiety can be caused by a variety of reasons. Let's figure it out:
Your main reason is most likely adolescence Yes!! there the aggression intensifies, and for several years!! When I grew up, I was still angry, but you are a guy - your rage is stronger! At this age, EVERYONE doubts that they are beautiful. Previously, I didn’t care because my body was doing other things. Now the body wants to be an adult... and is afraid that those who need it will not like it. Don't like that you're skinny? But your heart is acting up (by the way, once you get over your age, maybe your heart will calm down. It also played havoc with me when I was 14)? Consult your doctor about what kind of exercises you can do - and go in for sports. You will be more confident in yourself.
Then some other pills also cause anxiety. It's funny, but so are some types of worms). You clearly have an anxious state, for which your body is to blame. Tell yourself - I just think everything is bad, I'll figure it out soon. You can even draw a poster for yourself (no joke - you look at it, read it, and it’s not so scary anymore). Eat vitamins (live - fruits, vegetables, eat fish - it is good for the brain and bones. Health depends very much on what we eat, if the body is healthy - it and hormones will disturb it less. Stop eating chips, drinking soda, pasta - also bad food, it’s better not to drink alcohol at all, your body will thank you) Exercise in the morning, a walk before bed + Sports - and your body will stop messing with you.
Find interesting activities. Read. At least to show off. There is nothing more attractive than a sports guy who understands literature, history, philosophy... and how to assemble an atomic bomb (a joke, although there is some truth)) Next is a list of the first things that came to mind, which will clearly make you a more interesting person, and interesting personalities will never disappear:
Take up modeling (for example) - why not glue together a plane from the 2nd World War, while at the same time studying the aviation of those times? Or can you assemble Captain Blood's boat? At the same time, read about him - the author Sabatini, there will be something to show and tell both girls and boys. Fencing? I’m telling you honestly, even if there’s something wrong with your orientation, EVERYONE will be delighted with your activity. Maybe dancing? Just don't laugh. If you go to couples' dances - you love to cuddle some girl - that's where you'll decide what your sexuality is. If only she wasn't a scary girl. Try to draw if you haven’t really done it (art doesn’t count at school), but don’t give up if it doesn’t work out right away. Why not understand how the Chinese brew tea? Brew it for friends or parents - arrange a tea ceremony according to all the rules.
Now about orientation. Most likely, this is simply a product of your anxiety - your brain (quietly, at the subconscious level) begins to think that it is difficult to win a girl - they are so strange, incomprehensible, capricious. And guys are just like you, at least you know how to communicate with them. So your brain offers you a simpler option.

Stop paying attention to your body and any symptoms, distract yourself with an interesting activity and actively engage in it...

How hard do medications damage the liver? I can't live without them

Do you think you can live without a liver?!

Doctors choose Mexidol! Russian Pharma Awards 2014! In 2014, according to the results of an anonymous vote that took place on the Doctor at Work website, where more than 340 thousand doctors are registered...

Try to minimize the intake, if possible, refuse. 99% of drugs are useless or harmful. The power is in you bro! God gives you life without drugs. Don't trust anyone, you will live! You must live!

A LIVER NEEDS NOT ONLY TO BE PLANTED, BUT ALSO TO GROW

Eat Mexidol.

This means you need to support your liver. The doctor must prescribe medicine for the liver. I recommend what helped me. Milk thistle. Buy milk thistle seeds (fruits) at the pharmacy. Grind in a coffee grinder and take milk thistle powder in its raw form, a teaspoon 3-4 times a day. Just eat a spoonful of milk thistle.

Mexidol is a drug for improving blood supply to the brain. What does Mexidol help with? Instructions for use of Mexidol in tablets and injections. Use of Mexidol during pregnancy. Can Mexidol be given to children? Composition and analogues of Mexidol...

Well, no more than alcohol! I've been drinking alcohol for many years, so far nothing! There are absolutely no pills, except maybe allochol and corvalol.

In parallel with medications, take Essentiale-Forte, or Essliver-Forte, or milk thistle oil in capsules in good quantities.

Off topic, but to the address
from cosmetics:
- the liver is responsible for ALL skin, including hair and the skin under the hair
- dandruff is a result of poor nutrition;
- dry / greasy hair- the same thing.
- intake of animal fat (beef, pork, etc.) - during the period of hormonal “surge” (critical days) - causes an acute reaction of the liver / skin... pimples...
A simple refusal of heavy animal fat (primarily pork) will calm your liver.
Ideal (light) animal fats: fish, lamb.
- ideal soap (for fighting acne) - with increased Ph - the most ordinary laundry or tar soap.
The main destroyers of tooth enamel are weak acids - lactic, sugar, etc.
Saving teeth - rinsing oral cavity- after eating any food. A simple rinse, mind you.
obstructed outflow of venous blood and a bloated abdomen are the cause of many diseases:
- pulling the hip joint with a trouser belt or clothing - impedes the outflow of venous blood (and lymph), which leads to stagnation of blood (and lymph!)... prostatitis, thrombophlebitis, joint deposits of salts and tede...
- in women - pulling the chest lift with a lift leads to a “headache”...
- swallowing air when drinking water or eating other food - leads to the formation of air “plugs” in the intestines, bloating, constipation - learn NOT to swallow air!
- eating gas-forming food - see above - exclude cabbage, onions, peas (no milk) from your diet or learn to cook properly!
- a swollen belly (and also) puts pressure on the heart with the diaphragm...
from shoes:
- the leather insole is very hygienic!
- constant walking in shoes without heels leads to flat feet, the cut is easily corrected with a simple heel pad - made of thick felt (washed, odorless). Control your children's shoes!
Wear sneakers for your health!
Once a day you need to climb up to the third floor...
go up to the first floor slowly, to the second quickly (in jerks), to the third - slowly - through two steps.
This will stimulate the work of the hip joint.
in any Religion - during hot months, weeks, days - Lent!
because salty (and sweet) food forces the body to take more water... even more... increased load on the kidneys, heart... sweating... hypothermia (local) from the slightest draft (!)... colds.
Krch, - I abstain from meat in the summer.
to topic:
- eat solid food once a day, irritating wall esophagus, which causes the release of bile by this irritation, sharply activating the work of the stomach and intestines => regular bowel movements every day. For example, apples, cucumbers, vinaigrettes, salads, undercooked cereals (buckwheat, rice, etc.). BUT - a separate technique - from “liquid” food (soup, drink, tea).
Regular bowel movements are the basis of longevity!
Sim, I’m approaching my 63rd year.
No matter how hard the doctors tried... he survived.
No faith in doctors / they are silent like partisans during interrogation / or - they DO NOT know...

How to cure trichomanasic prostatitis? I’ve been in treatment for a year now... of course it’s become 70 percent easier

Afala try it. And among antibiotics, Abaktal is a good one.

Luda, writes February 1, 2012, 17 41. A neurologist, a vertebroneurologist is required. Please tell me MEXIDOL tablets are taken before or after meals.

It's too late, my friend, to drink Borjomi

The course of treatment must include physical therapy, a magnet, a laser, follow a diet and maintain motor activity in the pelvic area. Well, get treatment for STDs together with your partner...

Drink an antibiotic

You're up to your ears in used chocolate. I read the questions. Are you like 25?

Go to the hospital

How to take Mexidol tablets before or after meals? medication tags, Mexidol. Doctors say that Mexidol tablets can be taken regardless of the time of meal.

Treat yourself only with the help of doctors!

You don't mean protection with your wife repeated infections There is no cure for it, although it looks like you infected it. That’s why your case is very difficult. Don’t even think about children and how to get treatment because she must be examined together with you and only then treated according to indications. And if you want everything to work out, contact us

Who is Trichomonas? Worms?

Every day you stand on the applicator under your right thumb until the pain goes away.

Change hospital.

Consultation on the topic - Using MEXIDOL - Hello! Please tell me when to take MEXIDOL tablets, before or after meals.

You can only heal

Now this can be treated with currents and is much more effective than tablets

Do you, little guy, maintain sexual rest during treatment?

Go to a urologist

Unfortunately, doctors, out of ignorance or intentionally, do not take into account the rule that this is treated ONLY together with a sexual partner (partners). Otherwise, all treatment is useless. And by the way, the treatment is very good and inexpensive.

Mexidol is a good drug and also similar to Actovegin, at about the same level. You can take it with tanakan. Take regardless of food.

Go to the hospital

Doctors don't treat people these days... especially in Russia

Have you been prescribed Metronidazole? Prostasabal in capsules? Mexidol and milgamma injections intramuscularly.

This is still an infection, maybe it’s not a microbe. and the virus

Immediately I asked what is the best way to take Mexidol tablets before or after meals, because... I don’t always manage to have a snack at work. The doctor prescribed taking 3 tablets. per day after meals.

U3pikirfkurfuk

Combine the treatment that the doctor prescribed and a complex for those who carelessly caught a cold: daily push-ups, squats and abs. maybe this will help? take care of yourself

Have you tried Vitaprost Plus? They prescribed it to me, it helped. All sorts of simpletons, afala - these are dummies, you need serious artillery. I also took tests, but before and after treatment

No vitality. How to cheer up?

Should Mexidol tablets be taken before or after meals, is this not written in the instructions? And the child also started vomiting from anxiety, while crying, while eating.

To the village to grandma ---sunbathe-------

The best antidepressant is new man. Buy a gym or pool membership.

Sorry, this is not a dating site. .

If you do everything listed above and don’t fall on the couch right after work, then everything is fine with your energy.

Maybe your unsuccessful marriage is leaving sediment on your soul? Over time it will pass, and a craving for a new life will appear.

Girls, please tell me, we visited Bessonova, she prescribed us this drug and quickly ran away. I didn’t have time to ask whether to take it before or after meals, it’s not indicated in the instructions? You can take Mexidol in different times days.

After work, go to and practice line dancing.. drink a glass of clean water every 2 hours.. eat lentils.. Bolivian gruel.. drink green tea.... etc.. and life is super.. even for me..

Go travel somewhere, shake yourself up, change your surroundings.

healthy lifestyle pure form this is a perversion. Learn to relax, drinking, smoking, company, sex. Or you will regret your worthless life by 40

Only children

Cruise

How to take Mexidol tablets 0.125 correctly, before meals, after meals, or it doesn’t matter is not indicated in the annotation.

Help kill chronic fatigue syndrome in yourself! I have been suffering for many years, but in the last year it has gotten even worse.

Make an appointment with the doctor. At least he's an expert.

Mexidol is taken orally after meals in two tablets in the morning and evening for seven days. Side effect. Rarely possible individual allergic reactions, nausea, vomiting, dry mouth.

In a word, lazy and dreamer...
You need a good psychologist, otherwise you will soon become a client of a psychiatrist.

Syndrome chronic fatigue--- a fictitious disease. In Stalin's time, this condition was treated by working from 9 am to 9 pm without lunch, smoking breaks for a crust of bread.

You need to understand as an alcoholic that if he doesn’t stop drinking, he will disappear. You need to take full charge of yourself, stop eating sweets, you need to understand that this can lead you to diabetes mellitus, which cannot be cured, you need to take care of your appearance, lose excess weight, eat less delicious buns, if you run often you will immediately feel changes to to the best.

Heh.... I see that there is a desire, but no strength. I’m afraid this is not a matter of chronic fatigue, but of some kind of hidden but progressive disease.
First, donate blood for sugar, rule out diabetes. Complete blood test to look at hemoglobin and rule out anemia. With anemia, similar sensations and drowsiness occur. Any physical effort... is unbearable, even to the point of shortness of breath. Well then... we'll see.

Tell me, does anyone know whether to give Mexidol and Glycine to a child before or after meals???

There is no need to panic... According to the symptoms described, your serotonin levels are low. You can take drugs that increase its level. (paroxetine, sertraline, citalopram, fluvoxamine, etc. The pharmacy will tell you)
The simplest and most effective non-drug way to increase the amount of serotonin in the blood is to be in the sun as often and as long as possible. It is necessary to eat right, preferring foods that increase serotonin levels:
milk and fermented milk
banana (ripe, not green)
legumes (especially beans and lentils)
dried fruits (dates, figs, dried bananas)
sweet fruits (plum, pear, peach)
nightshades (tomato, bell pepper)
bitter dark chocolate
eggs (chicken or quail)
cereals (buckwheat and millet porridge).

In this article you can read the instructions for use of the drug Mexidol. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Mexidol in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Mexidol analogues, if available structural analogues. Use for the treatment of encephalopathies of various origins, cranial brain injuries, asthenic conditions and many other brain disorders in adults, children, as well as during pregnancy and lactation.

Mexidol- antioxidant drug.

Mexidol is an inhibitor of free radical processes and a membrane protector. It has antihypoxic, antistress, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotics /neuroleptics).

The mechanism of action of Mexidol is due to its antioxidant, antihypoxic and membrane protective effects. The drug inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, neurotransmitter transport and improve synaptic transmission. Mexidol increases dopamine levels in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has a hypolipidemic effect, reduces the content total cholesterol and LDL.

The anti-stress effect is manifested in the normalization of post-stress behavior, somato-vegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures brain.

Mexidol has a pronounced antitoxic effect in withdrawal symptoms. Eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Pharmacokinetics

After taking the drug orally in doses of 400-500 mg, it is quickly absorbed. Quickly distributed in organs and tissues. It is rapidly excreted in the urine, mainly in the form of metabolites and in small quantities unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug.

Indications

• consequences of acute cerebrovascular accidents, incl. after transient ischemic attacks, in the subcompensation phase as preventive courses;
• mild traumatic brain injury, consequences of traumatic brain injury;
• encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
• autonomic dystonia syndrome;
• mild cognitive disorders of atherosclerotic origin;
• anxiety disorders in neurotic and neurosis-like conditions;
• relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;
• conditions after acute intoxication with antipsychotic drugs;
• asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and stress;
• exposure to extreme (stress) factors.

Release forms

Solution for intravenous and intramuscular administration (in injections (ampoules)) 50 mg/ml (5%).

Film-coated tablets 125 mg.

Instructions for use and dosage regimen

The drug is prescribed orally at 125-250 mg 3 times a day. The initial dose is 125-250 mg (1-2 tablets) 1-2 times a day with a gradual increase until a therapeutic effect is obtained. The maximum daily dose is 800 mg (6 tablets).

Duration of treatment is 2-6 weeks, for relief of alcohol withdrawal - 5-7 days.

Treatment is stopped gradually, reducing the dose over 2-3 days.

Side effect

• dyspepsia;
• allergic reactions.

Contraindications

• acute liver failure;
• acute renal failure;
• hypersensitivity to the drug.

Due to insufficient knowledge of the effect of the drug:

• childhood;
• pregnancy;
• lactation period ( breastfeeding).

Use during pregnancy and breastfeeding

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug's effect.

special instructions

Mexidol can be combined with all drugs used to treat somatic diseases.

Use in pediatrics

Mexidol is not prescribed to children due to insufficient knowledge of the drug's effect.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug interactions

When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants.

Mexidol reduces toxic effect ethyl alcohol (alcohol).

Analogues of the drug Mexidol

Structural analogues of the active substance:

• Medomexy;
• Mexidant;
• Mexico;
• Mexiprim;
• Mexicofin;
• Metostabil;
• Neurox;
• Cerecard;
• Ethylmethylhydroxypyridine succinate.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

The cardiovascular system often fails, especially due to age-related changes in organism. Weakness, drowsiness, autonomic disorders, or even atherosclerosis and heart failure appear. All these conditions are successfully relieved by the drug Mexidol. The question of when to inject Mexidol in the morning or evening worries many

Brief description of the drug

Mexidol is prescribed by a neurologist or cardiologist for the treatment of diseases of the brain, heart and nervous system. It helps perfectly both with mild vegetative-vascular disorders and with serious pathologies:

• asthenic syndrome due to alcohol dependence;
• acute cerebrovascular accident;
• coronary heart disease;
• stroke and heart attack;
• severe intoxication with neuroleptics;
• neurosis-like and psychosomatic disorders;
• oxygen starvation of tissues of various etiologies (hypoxia).

It is actively used during the recovery period after traumatic brain injuries and purulent inflammation of the abdominal organs. Approved for use by almost everyone except children (under 12 years old) and pregnant women. It is well tolerated, with the rare exception of individual intolerance to the components.

Mexidol is available in tablets and injections, which allows it to be used in different ways - orally, intramuscularly, intravenously. In this case, it can be administered in a stream or drip, depending on the severity of the condition. Doctors are inclined to believe that it is better to inject Mexidol for a more systemic and rapid effect.

When is the best time to inject Mexidol?

The injection form of the drug is available in the form of a concentrated solution in ampoules. 1 ml of medicine contains 50 mg of the active substance (ethylmethylhydroxypyridine succinate). There are no universal instructions for use. In each individual clinical case, an individual treatment regimen and course duration are selected:

• for mild autonomic disorders, an injection of Mexidol is given intramuscularly at a dosage of 50-100 mg per day for 2-4 weeks;
• severe conditions associated with cerebral circulatory dysfunction require drip or jet administration of the drug in an amount of 200-500 mg 2-4 times a day

Most experts agree that Mexidol should be injected in the morning, that is, in the first half of the day. There is good reason for this recommendation. The drug has a tonic effect, it invigorates and activates the cardiovascular system. If you inject before bedtime, it will be difficult to fall asleep. Therefore, for a one-time use, it is advisable to give the injection in the morning. If the treatment regimen involves dividing it into several doses, then the evening procedure should be carried out several hours before bedtime.

Mexidol is used exclusively as prescribed by a doctor, so the nuances of the timing of the injection are discussed individually.

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pillsman.org

Mexidol tablets: instructions for use

Mexidol is an antioxidant drug that realizes its effects through the inhibition of free radical processes. It also has membrane protective properties and can have nootropic, mild anticonvulsant, vasoactive and anxiolytic effects.

Available in biconvex form round tablets white or cream color. The active ingredient of Mexidol tablets isate, content 125 mg in 1 tablet. The substance was first synthesized in the 1980s at the State Research Institute of Pharmacology of the Russian Academy of Medical Sciences. Included in many standards for the provision of medical care in the Russian Federation. In addition to the active substance, the tablets contain excipients: macrogol, polyvinyl alcohol, talc and titanium compounds. It is also available in injections for intramuscular or intravenous injections.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication with alcoholic beverages or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes. Taking Mexidol improves the functioning of synapses, enhances the mechanism of compensatory glycolysis and reduces the inhibition of oxidative processes in the Krebs cycle under conditions of low oxygen content in cells.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence. Reduces the manifestations of acute alcohol intoxication, normalizes behavior, and relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.

Indications

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

• ACVA (hemorrhagic and ischemic stroke), as well as their consequences.
• TBI (concussion).
• Encephalopathy.
• Encephalopathy of combined origin.
• Anxiety disorders.
• Abstinence.
• Poisoning with antipsychotics.
• Asthenia.
• Weakness and dizziness as part of asthenia.
• Dizziness of various origins (with vascular diseases of the brain).

Contraindications

There are a number of contraindications to the use of the drug:

• Acute renal failure.
• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol for significant liver dysfunction.

Mode of application

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (125-250 mg) three times a day. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

For alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Overdose

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, general weakness or drowsiness may develop.

special instructions

When taking Mexidol tablets, you should remember special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, you should be careful when driving a car or performing potentially dangerous work that requires quick reaction and attention.

Storage conditions

Mexidol tablets should be stored in a dark, dry place at temperatures no higher than 24-25 degrees Celsius. The storage period should not exceed 3 years.

Analogues

Mexidol tablets are an original medicine. Generic drugs, the active ingredient of which is alsoate, are such drugs as Neurox, Mexifin, Mexiprim, Armadin, Mexidant, Mexicor, Cerecard, Metostabil, as well as some other drugs that are not widely used on the market.

Price

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices do not vary widely due to various factors and make up:

• Pack of 30 tablets 233-290 rubles.
• Pack of 50 tablets 350-475 rubles.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Video commentary by the author

vertigonet.ru

Mexidol tablets and injections: instructions for use, analogues

Mexidol - popular medicinal product, which was developed in 1996 by Russian scientists. Refers to a new generation of antioxidants, used to improve cerebral circulation. Member of the group nootropic drugs, the action of which is aimed at normalizing metabolic processes in brain cells and protecting them from free radicals. This allows Mexidol to be widely used in neurological practice.

Its use is not limited to one area of ​​medicine; the drug is used to treat various pathologies in psychiatry, surgery and narcology. The unique properties of the antioxidant allow not only to restore memory, speech and skills lost as a result of a stroke or ischemic brain damage, but also increase the body’s resistance to various intoxications and stressful situations. In addition, Mexidol, as part of complex therapy, helps to stop acute purulent-inflammatory processes in the abdominal cavity. Let us dwell in more detail on the therapeutic effect of this medicine, how to use it and tell you what it helps with.

Mexidol - the effect of the drug

Mexidol is an antioxidant agent with nootropic, antihypoxic, anticonvulsant and antistress effects. The main active ingredient is ethylmethylhydroxypyridine succinate. The main objective of the drug is to increase the body's resistance to the action of various damaging factors (hypoxia, cerebrovascular accident, ischemia, intoxication).

Mexidol helps improve blood microcirculation, better blood supply to the brain and restore metabolism in nerve cells. Under its action, the structure of cell membranes is stabilized, platelet aggregation is reduced, and cholesterol levels in the blood are reduced.

The nootropic effect of the drug is expressed in the activation of mental activity, increasing the ability to learn and assimilate information, and improving memory. As an antioxidant, the drug protects body cells from excessive oxidation, reduces the harmful effects of free radicals, slows down aging and increases the resistance of organs and tissues to oxygen starvation.

The use of Mexidol helps restore the disrupted sleep-wake cycle and reduce the rate of development of degenerative processes. When using the drug, the production of the “hormone of joy” - dopamine - increases, which makes Mexidol an excellent remedy for the treatment of depressive conditions.

This hormone helps relieve anxiety, suppresses anxiety and fear, helps with sleep disorders, neurological and autonomic disorders Oh. The drug has anti-stress, anticonvulsant and antihypoxic effects, promoting oxygen saturation in the blood.

The drug helps to weaken the toxic effect of alcohol, relieves acute withdrawal syndrome, restores behavioral disorders, and has an anticonvulsant effect. The combined use of Mexidol with tranquilizers, antidepressants, sleeping pills, and antipsychotics enhances their effect, which makes it possible to reduce the doses of these drugs and reduce adverse reactions.

When taken orally, Mexidol is quickly absorbed and distributed in organs and tissues. The drug is excreted from the body in the urine in the form of metabolites; a small amount of the drug is excreted unchanged. The greatest intensity of excretion is observed within 4 hours after taking a dose of the drug.

Composition and release form

Photo: Medicine Mexidol in the form of oral tablets

Mexidol is produced in two dosage forms:

• Medicine Mexidol in the form of oral tablets
• Mexidol in ampoules for IV and intramuscular administration

Mexidol tablets are biconvex, coated with a white or slightly cream color. In a cross section, two layers are visible: a gray core and a white outer shell. One tablet contains 125 mg of active ingredient. The drug is packaged in contour cell blisters of 10 tablets each (3-5 blisters per package) or plastic jars containing 90 tablets. For hospitals, the drug is sold in plastic containers containing 450 or 900 tablets.

The drug solution is produced in ampoules made of colorless or dark glass, with a white break point, which are packaged in 5 or 10 pieces in contour cellular blisters. One or two blisters are placed in a cardboard package with the drug. Mexidol ampoules have a volume of 2 and 5 ml. This form of the drug is a clear, colorless or slightly yellowish solution intended for infusion or intramuscular injection. 1 ml of solution contains 50 mg of active substance.

Mexidol is stored in a dry place, protected from light. Storage temperature should not exceed 25°C; all forms of the drug are suitable for use for 3 years.

When is Mexidol prescribed - indications

In medical practice, the list of diseases for which Mexidol is used is quite extensive. It is primarily used in neurology to treat the following conditions:

• Prevention and treatment of strokes in acute and recovery period
• Manifestations of vegetative-vascular dystonia
• Progressive cerebrovascular insufficiency (encephalopathy)
• Mild traumatic brain injury and its consequences
• Cognitive disorders resulting from atherosclerosis (impaired intelligence, memory, speech)
• Ischemic disease
• Asthenic syndrome

In psychiatry:

• Prevention of somatic neuroses
• Neurotic disorders: anxiety, sleep disorders
• For symptoms of antipsychotic poisoning
• Under extreme stress factors

In narcology:

• Relieving withdrawal symptoms
• Relieving alcohol withdrawal, manifested in vegetative-vascular and neurotic symptoms

In surgery:

• As part of complex therapeutic treatment for acute purulent-inflammatory pathologies of the peritoneum (peritonitis, necrotizing pancreatitis).

Experts consider the most appropriate use of Mexidol for sclerosis and encephalopathies of various etiologies, vegetative-vascular dystonia, convulsive conditions, epilepsy, neuroses, phobias and traumatic brain injuries.

Instructions for use (tablets, solution for injections)

Photo: Instructions for use (tablets, solution for injections)

According to the instructions for use of Mexidol, the drug, when taken orally, is prescribed 1-2 tablets three times a day. At the beginning of treatment, the recommended dose is taken once or twice a day, then the frequency of administration is increased to achieve the desired effect. The maximum daily dose should not exceed 800 mg (6 tablets). The duration of treatment is from 2 to 6 weeks; to relieve withdrawal symptoms, it is enough to take the drug for 7 days.

Treatment cannot be abruptly interrupted; the dose should be gradually reduced over 3 days until the drug is completely discontinued. The optimal treatment regimen is selected by the doctor, taking into account the individual characteristics of the patient, general condition and severity of symptoms. For ischemic disease, the course of treatment is longer - up to 8 weeks; if necessary, the doctor can prescribe a second course of therapy after a break. The most optimal period for a second course of treatment is spring and autumn.

Mexidol solution can be administered intravenously and intramuscularly. Before infusion administration using a dropper, the drug should be diluted in an isotonic sodium chloride solution. The rate of drip infusion should not exceed 40-60 drops per minute. The recommended volume of the drug is 100-150 ml. Jet injection must be done very slowly, over 5-6 minutes.

For the treatment of acute cerebrovascular accidents, the drug should be infused according to a specific schedule. In the first 10-14 days, a volume of 200-500 mg is given intravenously by drip 2 to 4 times a day. In the next 2 weeks, intramuscular injections are carried out, administering 200-250 mg of the drug 2-3 times a day.

To eliminate the consequences of traumatic brain injury, the drug is administered by drip in a volume of 200-500 mg from 2 to 4 times a day, depending on the patient’s condition. The course of therapy is 10-15 days.

For slowly progressing circulatory failure, the dose is selected individually by the attending physician. The drug is administered intravenously or by bolus once a day for 2 weeks. Further treatment is carried out using intramuscular injections.

At anxiety disorders and cognitive impairment in the elderly, the drug is administered intramuscularly in a daily dose of 100 to 300 mg. Treatment is carried out for 2-4 weeks.

To eliminate alcohol withdrawal, the medicine is infused intramuscularly or using a dropper. 2-3 procedures are performed per day, administering the drug in a volume of 200 to 500 mg.

At purulent abscesses abdominal cavity, Mexidol can be administered intravenously or intramuscularly the day before surgery, or on the first day after surgery. The dose is selected individually, it depends on the severity of the disease, the degree of damage and the general condition of the patient.

Contraindications

Contraindications to the use of the drug are:

• Individual intolerance to the components of the drug
• Pregnancy and breastfeeding period
• Childhood
• Acute dysfunction of the liver and kidneys

Since the effect of the drug has not been sufficiently studied, it is not used to treat children, pregnant and lactating women. Particular caution is taken when using Mexidol in patients with hypertension, low blood pressure, arterial hypertension accompanied by crises.

The instructions for the drug say that it is not prescribed in childhood, but in pediatrics it is still used in the treatment of traumatic brain injuries and purulent neuroinfections. As an emergency aid for injuries, a single use of Mexidol at a dose of 100 mg is indicated. In other cases, the dose of the drug is selected individually by the pediatrician and depends on the child’s condition, the severity of the pathological process and the general clinical picture. The treatment is carried out under the supervision of a specialist.

Side effects

Side effects

Side effects from the use of the drug are insignificant. Mexidol is characterized by low toxicity and does not have a negative effect on blood composition, respiratory rhythm, or heart rate. In rare cases, adverse reactions from the gastrointestinal tract may occur. After taking the pills, symptoms of a dyspeptic nature are noted, which manifest themselves as discomfort and painful sensations in the abdomen.

Patients complain of nausea, heartburn, a feeling of fullness and heaviness in the abdomen. This condition may be accompanied by the development of diarrhea. In some cases, individual reactions are expressed in appetite disturbance, flatulence, a feeling of weakness, and lethargy. With increased sensitivity to the components of the drug, allergic reactions occur.

When treated with Mexidol solution, patients may experience attacks of nausea, increased dry mouth, weakness and drowsiness. In rare cases, allergic reactions develop.

Taking the drug in high doses can provoke surges in blood pressure, increased emotional excitability, symptoms of hyperhidrosis, and impaired coordination of movements. In case of overdose, gastric lavage and other methods are used. symptomatic therapy.

Drug interactions with other drugs

Mexidol has good compatibility with all drugs used to treat somatic diseases. Simultaneous use with neuroleptics, antidepressants, tranquilizers and anticonvulsants enhances them therapeutic effect, which allows you to reduce the dose of these drugs and avoid the development of unwanted side reactions of the body.

Mexidol reduces the toxic effect of ethanol and promotes the removal of alcohol from the body. This feature of the drug is used to eliminate withdrawal symptoms in the treatment of alcohol addiction.

special instructions

The use of Mexidol in patients with bronchial asthma suffering from hypersensitivity to sulfites can cause the development of severe allergic reactions.

The drug can slow down the speed of reactions and reduce concentration, so it should be used with extreme caution when driving a vehicle or performing work involving dangerous mechanisms and requiring rapid psychomotor reactions.

Analogues

Mexidol has a number of analogues that are similar in composition and pharmacological action:

• Mexidant
• Mexiprim
• Mexicor
• Neurox
• Cerecard
• Combilipen
• Hypoxene

Many patients during treatment are interested in whether it is possible to replace Mexidol with cheaper analogues? Despite the fact that the drug is not cheap, it has established itself in the domestic market as the most effective and successful product. Many of its analogues, which have similar therapeutic effects, differ only in the composition of the excipients and, according to the doctor’s decision, can be used as part of combination therapy together with Mexidol.

But it is not recommended to independently replace the medicine with analogues, since many of them have undesirable side effects or may have insufficient therapeutic effect. The decision to replace should be made by a specialist who will take into account possible contraindications and select the required dosage.

Price

Average prices for the drug in the pharmacy chain:

• Mexidol tablets (30 pieces) – 220-280 rubles
• Mexidol tablets (50 pieces) – 350-380 rubles
• Mexidol solution (5 ampoules) – 350-470 rubles
• Mexidol solution (10 ampoules) – 380-500 rubles.

Reviews about the application

Review #1

Vegeto - vascular dystonia– a very unpleasant companion who has been accompanying me for the last few years. It becomes especially unpleasant when the seasons change: incessant headaches, dizziness and drowsiness. I had to seek help from a local clinic. The doctor advised Mexidol intramuscularly.

I read the instructions for use and realized that it suits me. To be honest, I did not expect any stunning effect from the drug. However, Mexidol not only met all my expectations, but also became a savior for me. The injections themselves turned out to be painless, and after ten such procedures I felt like a human being.

The most real person who leads active life and does not constantly suffer from dizziness, migraines and loss of energy. Plus, my concentration has improved, I can now do anything and not fall asleep on the go or lie on the bed suffering from a headache. I did not find any side effects during the treatment. The course of treatment has ended, the therapeutic effect is still lasting. If in the future old problems make themselves felt, now I know what will help me out.

Galina, Novosibirsk

Review #2

I myself have not taken this drug, but I had the opportunity to see it in action with my own eyes. Grandfather had a mini-stroke, his leg was partially paralyzed, he dragged it a lot when walking, speech was difficult. The attending physician prescribed Mexidol as one of the elements of complex treatment. As a result, after taking this drug, my grandfather began to feel better.

Over time, speech returned to normal, memory returned, and you can communicate with him as before. Today, no signs of the attack are visible. Grandfather talks, walks independently, leads familiar image life. Everything returned to normal, and I am sure that Mexidol contributed to this.

Nastya, St. Petersburg

Review #3

My work involves mental activity. I have to spend almost the whole day at the computer. I began to suffer from severe headaches. The attacks were so strong that nausea set in. I went to the clinic. We conducted an examination and the doctor said that the headaches were caused by increased intracranial pressure and worsening cerebral circulation.

That is why I started having these attacks. The doctor prescribed Mexidol. I was afraid that the price would be too high, but for such an effective drug it turned out to be quite acceptable. I bought a pack of tablets (50 pieces) and started taking them. Within a week after starting treatment, the headache began to hurt less. And the work became easier, my concentration improved.

True, I felt discomfort in my stomach for some time, and dry mouth appeared, but these phenomena soon passed. After a month of taking the drug, I completely forgot about headaches. I even slept better. Two months have passed since the course of treatment, and so far everything is good: my head doesn’t hurt, I feel much better.

Olga, Moscow

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glavvrach.com

Instructions for use of the drug "Mexidol"

Mexidol comes with instructions for use, which allow you to understand all the properties of the drug, recommendations for use, and contraindications. The medication is sold in pharmacies only with a doctor's prescription, complete with official instructions from the manufacturer.

Composition of the drug and its pharmacological properties

The 1st ampoule of solution contains 50 mg of ethylmethylhydroxypyridine succinite. Auxiliary components: sodium metabisulfite, saline solution, magnesium stearate, sodium carmellose, lactose monohydrate, polyvinyl alcohol, talc, titanium dioxide. "Mexidol" tablets contain 125 mg of active substance.

The drug belongs to the group of nootropics and has a positive effect on all mental processes in the human body. Under the influence of the drug, many pathological changes stop their development. Thanks to the action of the medicine, a person sleeps better.

All this is achieved due to the fact that the active component in the drug is able to restore the functionality of cell membranes and remove free radicals from the body. Taking the drug helps saturate the blood with oxygen, relieves stress, and has anticonvulsant and antioxidant effects. Thanks to improved circulation in the circulatory system, cholesterol levels are reduced and the physiological qualities of plasma (viscosity, flow rate, etc.) are improved. In cellular mitochondria, the drug promotes the active formation of energy, and in nerve cells the transmission of synoptic impulses is significantly accelerated.

It is recommended to take Mexidol in combination with tranquilizers, antidepressants, antipsychotics, sleeping pills and anticonvulsants. The active substance in the medicine only enhances the effect of the above medications. This combination allows you to reduce the dose, which eliminates many side effects.

Wide Application"Mexidol" was found in dentistry.

Treatment with Mexidol during pregnancy is not recommended, since there is no reliable data on clinical studies on patients taking this drug during pregnancy.

The drug is often used in complex therapy of children with traumatic brain injuries and purulent neuroinfections. A single dosage is prescribed only by the attending physician. The child is closely monitored while taking the medicine.

In what situations is it used and possible contraindications?

The use of the drug "Mexidol" is indicated for the following diseases:

• vegetative-vascular dystonia;
• disturbances of speech function, intellectual activity, memory and attention;
• vascular diseases in brain tissue;
• withdrawal syndrome that occurs during alcoholism;
• neuroses;
• poisoning antipsychotic drugs;
• inflammatory processes with purulent formations in the peritoneal organs.

Taking the drug is contraindicated for persons who have been identified as individual intolerant to Mexidol. It is also not recommended to drink Mexidol for acute renal and liver failure.

The medicine is practically non-toxic, so the side effects of Mexidol occur very rarely. Regardless of dosage, it does not affect the patient's physical activity level or physiological functions. All reflexes, hemodynamic processes, blood pressure, body temperature remain normal. An overdose may cause nausea and drowsiness. Dry mouth occurs, but quickly goes away on its own. Hypersensitivity to the active substance sometimes causes allergic manifestations in the form of a skin rash.

Due to the drug’s ability to quickly remove toxins and free radicals from the body, it is used to relieve painful symptoms of alcohol intoxication.

Types of drug

"Mexidol" tablets. The initial dosage is 1 – 2 tablets 2 times a day, after which the frequency of administration is increased to 3 times a day. Treatment therapy lasts on average 2–6 weeks, depending on the severity of the disease and the general condition of the patient. The dosage is gradually reduced, approaching the completion of the therapeutic course of treatment. So, people suffering alcohol addiction, drank Mexidol for 7 days.

Rinsing and applying applications. In dental practice, Mexidol injection solutions are successfully used for rinsing the mouth and washing periodontal pockets. Good effect give local applications with the solution. Procedures must be performed regularly, at least 3 times a day. Treatment takes as long as necessary to achieve positive dynamics in the development of the pathology.

Injection. The 5% solution is produced in ampoules of 2 ml. It can be used for intravenous, intramuscular injections, droppers. Saline solution is used as a solvent.

The dose is strictly individually selected by the attending physician depending on the purpose, disease and severity of its course. Treatment is started with the minimum dose, then increased to the maximum allowable. Up to 0.8 g of the drug can be administered per day.

Treatment of dementia in older patients is carried out using intramuscular injections. The drug, administered intravenously, is good for acute intoxication of the body and inflammatory diseases of the peritoneal organs.

The drug "Mexidol" is well absorbed and quickly eliminated from the body. It undergoes breakdown in the liver within 5 hours after the first dose, then is completely excreted in the urine.

"Mexidol" in dentistry

Due to the property of Mexidol to have an anti-inflammatory and antioxidant effect, it is widely used in dentistry as a therapeutic and prophylactic agent for stomatitis, gingivitis, and caries. It is added to toothpaste, which fights periodontitis, stops bleeding gums, reduces their sensitivity, eliminates pathogenic bacteria, and significantly increases immunity in the oral cavity. After regular use of Mexidol Dent toothpaste, patients note healing of wounds, restoration of the oral mucosa, and the disappearance of unpleasant odor.

It is recommended to brush your teeth with Mexidol Dent 3 times a day or after meals. If the sensitivity of the gums is excessively high, then doctors prescribe Mexidol Dent Sensitive. The paste contains potassium nitrate. This substance allows you to block nerve endings, which reduces the general sensitivity of teeth that occurs in many diseases. With regular use of the paste, many painful symptoms go away.

Toothpaste has an effective whitening effect and quickly relieves inflammation. Plaque is removed with papain. It contains calcium citrate and hydroxyapatite. These substances penetrate deep into the enamel of the teeth after the plaque from their surface is completely removed. For a long period of time, teeth remain fresh, clean and White color.

The effect of Mexidol in the treatment of other diseases

For the drug to be effective, it is necessary to adhere to a strictly defined treatment regimen:

1. If blood circulation in the brain tissue is impaired, the drug is administered via a dropper for 2 weeks. The maximum permissible dose per day is 500 mg. Then they begin to gradually reduce the dosage of the drug, bringing it to 250 mg per day.
2. Encephalopathy in the acute phase. The medicine is administered intravenously 2 times a day for 2 weeks. The dosage ranges from 250 to 500 ml of Mexidol. After this, over the next 2 weeks, reduce the administration of the drug to half the original dosage.
3. Mild disorders of the mental processes of the central nervous system in older patients require treatment with intramuscular injections. The course of therapy ranges from 2 weeks to 30 days. 100–300 ml of the drug is administered. The medication is also used to prevent many mental illnesses.
4. To eliminate withdrawal symptoms alcohol syndrome or withdrawal symptoms, the doctor prescribes up to 250 mg of Mexidol, administered intravenously or intramuscularly. The duration of treatment is 5 – 6 days.
5. Neuroleptic poisoning occurs from uncontrolled use of the drug. Painful symptoms are quickly relieved with intravenous injections with a maximum dose of 500 mg.
6. In case of purulent infections of the peritoneum, as well as inflammatory processes of its organs, Mexidol is used from the first hours after surgery. The doctor calculates the dosage of the drug depending on the severity of the disease, form and individual characteristics. As soon as the therapeutic effect is achieved, the drug begins to be gradually withdrawn.
7. Acute pancreatitis accompanied by swelling. A maximum dosage of up to 500 mg per day 3 times a day is allowed. The medication is administered using a dropper or intramuscularly.
8. Moderate purulent pancreatitis. Treat only with a dropper using 200 mg of the drug. The course of treatment lasts from 2 to 4 weeks. Droppers must be placed 3 times a day.
9. Necrotizing pancreatitis. Treatment is prescribed using a large dose (up to 500 mg per day). The medicine is administered intravenously for 2 weeks. After this, they begin to gradually reduce the dosage.

Necrotizing pancreatitis is extremely severe. It is necessary to take up to 800 mg of medication per day or until the painful symptoms and shock completely disappear. After the patient's condition becomes stable, the dosage is gradually reduced. The medication is administered only after meals.

Analogues

Mexidol appeared on the domestic market relatively recently, but has already established itself due to its effectiveness and speed of action. However, its clinical studies have not yet been fully completed and continue to this day. If a drug does not give a good result over a certain period of time, then it is necessary to replace it with a drug of a similar composition and effect. The choice is made only by the doctor, based on the individual characteristics of the patient, the type of disease and its severity.

"Mexiprim" is an analogue of the Russian "Mexidol", produced in Germany. Mexiprim and Mexidol have the same active ingredient. The only difference is in the composition of the excipients. If you compare which is better - Mexidol or Mexiprim, then it is advisable to leave the choice to your doctor. Before you start using Mexiprim, you must carefully study the instructions for use.

In addition to Mexiprim, the medicine has many other analogues: Cavinton, Mildronate, Neurox, Cortexin, Nootropil and others.

As for Cavinton, it is not advisable to take it simultaneously with Mexidol. When used separately, both drugs give excellent results in therapeutic therapy. "Cavinton" gives a positive effect when trying to restore cerebral circulation, improve blood pressure, and restore the supply of oxygen to brain tissue. This drug is often used in the treatment of ophthalmological diseases and ENT organs.

"Neurox" is a complete analogue of "Mexidol", since it contains the same active component.

Mildronate is an effective vasodilator. With its help, you can quickly and effectively restore the supply of oxygen to brain tissue and improve blood supply. The medicine is often taken during the complex treatment of coronary artery disease. It lowers high blood pressure, has effective impact on humoral and cellular immunity.

"Cortexin" is a drug created on the basis of an extract from the brain of cattle. It has a particularly powerful effect in the treatment of newborn patients with hypoxia of brain tissue.

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An original domestic antihypoxant and direct-acting antioxidant that optimizes the energy supply of cells and increases the body's reserve capabilities

Mexidol main effects, mechanism of action, application

Domestic drug of a new generation

T.A. Voronina

REVIVING THE ENERGY OF LIFE!

NEUROLOGY: acute cerebrovascular accidents (stroke), atherosclerotic disorders of brain function, dyscirculatory encephalopathy.

SURGERY: acute purulent-inflammatory processes of the abdominal cavity (acute destructive pancreatitis, peritonitis).

PSYCHIATRY: relief of withdrawal syndrome with the presence in the clinical picture of neurosis-like and vegetative-vascular disorders, as well as acute intoxication with neuroleptics

MEXIDOL (ethylmethylhydroxypyridine succinate)

Dosage form:

5% solution for injection in ampoules of 2 ml No. 10,

film-coated tablets 125 mg No. 30 Mexidol - 2-ethyl-6-methyl-3-hydroxypyridine succinate was synthesized at the Institute of Biochemical Physics of the Russian Academy of Sciences; studied and developed at the Research Institute of Pharmacology of the Russian Academy of Medical Sciences and the All-Russian Scientific Center for the safety of biologically active substances. Mexidol is approved for wide use medical use and is indicated for the treatment of acute cerebrovascular accidents, discirculatory encephalopathy, vegetative-vascular dystonia, atherosclerotic disorders of brain function, neurotic and neurosis-like disorders with anxiety, for the relief of withdrawal syndrome in alcoholism, for the treatment of acute intoxication with neuroleptics and a number of other diseases. Mexidol is a new type of drug, both in mechanism and in the spectrum of pharmacological action and has significant advantages over known neuro- psychotropic drugs. MECHANISM OF ACTION Mexidol has an original mechanism of action, the fundamental difference of which from the mechanism of action of traditional neuropsychotropic drugs is its lack of specific binding to known receptors. Mexidol is an inhibitor of free radical processes, lipid peroxidation, it activates superoxide dismutase, affects the physicochemical properties of the membrane, increases the content of polar lipid fractions (phosphotidylserine and phosphotidylinositol, etc.) in the membrane, reduces the cholesterol/phospholipid ratio, reduces the viscosity of lipid layer and increases the fluidity of the membrane, activates the energy-synthesizing functions of mitochondria and improves energy metabolism in the cell and, thus, protects the cell apparatus and the structure of their membranes. The change in the functional activity of the biological membrane caused by Mexidol leads to conformational changes in the protein macromolecules of synaptic membranes, as a result of which Mexidol has a modulating effect on the activity of membrane-bound enzymes, ion channels and receptor complexes, in particular, benzodiazepine, GABA, acetylcholine, enhancing their ability to bind to ligands, increasing the activity of neurotransmitters and the activation of synaptic processes. Along with this, Mexidol has a pronounced lipid-lowering effect, reduces the level of total cholesterol and low-density lipoproteins and increases high-density lipoproteins. Thus, the mechanism of action of Mexidol is determined primarily by its antioxidant properties, the ability to stabilize cell biomembranes, activate the energy-synthesizing functions of mitochondria, modulate the functioning of receptor complexes and the passage of ionic currents, enhance the binding of endogenous substances, improve synaptic transmission and the interconnection of brain structures. Thanks to this mechanism of action, Mexidol influences the key basic links in the pathogenesis of various diseases, has a wide range of effects, extremely few side effects and low toxicity, and has the ability to potentiate the action of other centrally active substances, especially those that act as direct receptor agonists. PHARMACODYNAMICS Mexidol, unlike well-known drugs, has wide range pharmacological effects, realized at least at two levels - neuronal and vascular. It has cerebroprotective, anti-alcohol, nootropic, antihypoxic, tranquilizing, anticonvulsant, antiparkinsonian, anti-stress, vegetotropic effects. In addition, it has the ability to improve cerebral circulation, inhibit platelet aggregation, reduce general level cholesterol, have an antiatherosclerotic effect. The therapeutic effects of Mexidol are detected in the dose range from 10 to 300 mg/kg. Mexidol increases the body's resistance to various extreme damaging factors, such as sleep disturbance, conflict situations, stress, brain injury, electric shock, physical activity, hypoxia, ischemia, various intoxications , including ethanol. Mexidol has a pronounced tranquilizing and anti-stress effect, the ability to eliminate anxiety, fear, tension, restlessness, in particular in conflict situations. When administered parenterally, it has a similar depth of effect to diazepam (Seduxen) and alprazolam (Xanax). The anti-stress effect of Mexidol is expressed in the normalization of post-aggressive behavior, somatovegetative indicators, restoration of sleep-wake cycles and impaired learning and memory processes, reduction of stomach ulcers, reduction of dystrophic, morphological changes that occur after stress in various structures of the brain and in the myocardium. Mexidol has a distinct anticonvulsant effect, influencing both primary generalized seizures, caused primarily by the administration of GABAergic substances, and the epileptiform activity of the brain with a chronic epileptogenic focus. The nootropic properties of Mexidol are expressed in the ability to improve learning and memory, promote the preservation of a memorable trace and counteract the process of extinction of acquired skills and reflexes. Mexidol has a pronounced anti-amnestic effect, eliminating memory impairment caused by various influences (electric shock, brain injury, sleep deprivation, administration of scopolamine, ethanol, benzodiazepines, etc.). Mexidol has a distinct antihypoxic and antiischemic effect, which is expressed in the ability of the drug to increase life expectancy and the number of surviving animals under various hypoxic conditions: hypobaric hypoxia, hypoxia with hypercapnia in a hermetic volume and hemic hypoxia. In terms of antihypoxic activity, Mexidol is significantly superior to pyritinol and piracetam, which at doses of 300 and even 500 mg/kg have weak antihypoxic activity under conditions of acute hypobaric hypoxia and hypoxia with hypercapnia. In addition, Mexidol has a pronounced antihypoxic effect on the myocardium in experiments on an isolated, perforated, contracting heart. According to the mechanism by which these effects are realized, Mexidol is an antihypoxant with a direct energizing effect, the effect of which is associated with the influence on the endogenous respiration of mitochondria, with the activation of the energy-synthesizing function of mitochondria. The antihypoxic effect of Mexidol is due not only to its own antioxidant properties, but also to its constituent succinate, which, under hypoxic conditions, entering the intracellular space, can be oxidized by the respiratory chain. Mexidol has a pronounced anti-alcohol effect. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication caused by a single injection of high doses of ethanol, and also restores behavioral disorders of the vegetative and emotional status, deterioration of cognitive functions, learning and memory processes caused by long-term (5 months) administration of ethanol and its withdrawal, and prevents accumulation of lipofuscin in the brain of alcoholized animals. Mexidol has a pronounced geroprotective effect, has a clear corrective effect on learning and memory processes impaired during aging, improving the process of fixation, storage and reproduction of information, helps restore emotional and vegetative status, reduces manifestations of neurological deficits, reduces the level of aging markers - lipofuscin - in the brain and blood , malonaldehyde, cholesterol. The mechanism of the geroprotective action of Mexidol is associated with its antioxidant properties, the ability to inhibit lipid peroxidation processes, its direct membranotropic effect, the ability to restore ultrastructural changes in the granular endoplasmic reticulum and mitochondria, and modulate the functioning of receptor complexes. Mexidol has an antiatherogenic effect. The drug inhibits the humoral manifestations of atheroarteriosclerosis: reduces hyperlipidemia, prevents the activation of lipid peroxidation, increases the activity of the antioxidant system, prevents the development of pathological changes in vascular wall and reduces the degree of damage to the aorta. Mexidol reduces the content of atherogenic lipoproteins and triglycerides, increases the level of high-density lipoproteins in the blood serum, and prevents deficiency of highly unsaturated phospholipids. Mexidol not only causes regression of atherosclerotic changes in the main arteries and restores lipid homeostasis, but also corrects disturbances in the regulatory and microcirculatory systems, which is expressed in the fact that there is no structure of arterioles and precapillaries, and their diameter differs little from the control, only focal ones are determined in venules aggregates, and complete elimination of spasm of afferent microvessels is observed. In addition, 2-ethyl-6-methyl-3-hydroxypyridine derivatives, which include Mexidol, suppress platelet aggregation caused by collagen, thrombin, ADP and arachidonic acid, inhibit platelet cyclic nucleotide phosphodiesterase, and also protect blood cells during mechanical injury. In particular, stabilizing resistance of erythrocyte membranes to hemolysis is observed and the process of hematopoiesis (restoration of the number of erythrocytes) after acute blood loss or chemical hemolysis is accelerated. The hepatoprotective effect of Mexidol was established in three models of acute toxic damage livers in which hepatocyte cytolysis syndrome was caused by various hepatotoxins. In conditions of liver damage caused by carbon tetrachloride, Mexidol reduces areas of liver tissue necrosis and the volume of fatty degeneration of hepatocytes, normalizes the energy balance of hepatocytes, and has a protective effect on the nuclear and cytoplasmic pool of nucleic acids. In case of alcoholic liver damage, the effect of Mexidol is expressed in a decrease in the number of hepatocytes with lysis of nuclei and chromatin, acceleration of restoration of the total genome of hepatocytes and an increase in the content of nucleic acids in the liver tissue and nuclei of hepatocytes. 3-hydroxypyridine derivatives have a protective effect against the toxic effect on the liver of the strong hepatotropic carcinogen diethylnitrosoamine (DENA), since they form complexes with cytochrome P-450 and thereby prevent its complex formation with DENA. Mexidol has a pronounced ability to have a potentiating effect on the effects of other neuropsychotropic drugs. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects. In particular, when Mexidol is combined with carbamazepine, the dose of the anticonvulsant can be reduced by 2 times without reducing its therapeutic effect. Combined use Mexidol with carbamazepine allows for adequate pathogenetic therapy of partial epilepsy, reducing side effect carbamazepine with long-term use, without reducing its therapeutic effectiveness and thereby optimizing the treatment of patients with epilepsy. Side effects and toxicity A significant advantage of Mexidol is that it has minor side effects and low toxicity. When studying the side effects of Mexidol, it was found that it is even in the upper range therapeutic doses has neither a depressing nor a stimulating effect on spontaneous motor activity, does not change the coordination of movements, the orientation-exploratory behavior of animals, rectal temperature, corneal and pineal reflexes, and does not cause drowsiness. The drug maintains the adequacy of the animals' response to the stimuli provoking the test, and simple reflexes are not impaired. With an increase in the average therapeutic dose by 4-5.5 times, Mexidol does not have a muscle relaxant effect. Along with this, Mexidol, even in extremely high doses, does not impair memory and does not cause amnesia, but, on the contrary, has an anti-amnestic effect in case of memory impairment. Mexidol does not have a negative effect on the liver, but on the contrary, has a hepatoprotective effect. The drug does not change the heart rate, does not change blood pressure, ECG, hemodynamics and breathing rhythm, does not cause changes in the composition of the blood, skin color and mucous membranes, urination, bowel movements and salivation. Side effects Mexidol is expressed mainly in inhibition of motor activity and impaired coordination of movements and begins to appear in individual animals when doses are increased to 300 mg/kg and higher when administered intraperitoneally and in doses of 400 mg/kg and higher when Mexidol is administered orally. Long-term administration Mexidol (2-3 months) does not cause a decrease in its therapeutic effect or the appearance of additional undesirable manifestations. After stopping long-term administration of Mexidol, no withdrawal syndrome is observed. Acute toxicity Mexidol was determined by recording the death of animals 24 hours after administration of the drug. The lethal dose of Mexidol, causing the death of 50% of animals (LD50) is 820 (625 - 1025) mg/kg for rats and 475 (365 -617) mg/kg for mice, and when administered orally - more than 3000 mg/kg in rats and 2010 (1608 - 2513) mg/kg in mice. Studying chronic toxicity Long-term use of Mexidol orally and parenterally in experimental animals did not reveal significant changes in the organs and tissues of the body. Comparison of effective therapeutic doses of Mexidol with doses that cause side effects (sedation, incoordination, ND50) or toxic, lethal doses(LD50) shows the significant therapeutic breadth of Mexidol. The therapeutic index calculated from the LD50/ED50 ratio is 6.2, and from the LD50/ED50 ratio is 16.4, which indicates the harmlessness and safety of the drug. PHARMACOKINETICS AND METABOLISM Mexidol has high bioavailability. When administered parenterally to rats, it is rapidly absorbed from the abdominal cavity with a half-absorption period of 0.94 hours and maximum concentrations in plasma are reached after 3 hours, and in the brain and liver of animals after 2-3 hours. A study of the binding ability of the membranes of the endoplasmic reticulum of the liver and brain of rats with Mexidol showed that the substance is determined in significant quantities in the membranes for 72 hours, which indicates the membranotropic properties of Mexidol. After intravenous administration of Mexidol to rabbits, the substance is eliminated from the blood plasma bioexponentially and can be determined according to theoretical calculations in fairly high concentrations for 6-12 hours. The high lipophilicity of Mexidol, its ability to bind to blood plasma proteins and endoplasmic reticulum membranes suggest the formation of tissue and blood depots of Mexidol in the body of animals. Analysis of the pharmacokinetic parameters of Mexidol in patients in the clinic showed that both with a single dose and with course application, the concentration of Mexidol in the blood increases quite quickly, reaching a maximum after an average of 0.58 hours. At the same time, Mexidol is quickly eliminated from the blood and after 4 hours it is practically not registered. The pharmacokinetic profiles of the drug did not differ significantly between single and chronic administration. A study of the excretion of Mexidol in the urine showed that it is excreted both unchanged and in the form of a glucuronoconjugate, which constitutes a significant amount. When studying the metabolism of Mexidol in rats, 5 metabolites were identified. Metabolite I is phosphate (at the hydroxy group) of 3-hydroxypyridine, the formation of which occurs in the liver. In the blood under the influence alkaline phosphatase 3-hydroxypyridine phosphate is split into phosphoric acid and 3-hydroxypyridine. Metabolite II - 2-methyl-6-methyl-3-hydroxypyridine - is formed in large quantities and is found in urine on the first and second days after Mexidol administration; this metabolite has a spectrum of pharmacological activity close to Mexidol. Metabolite III - 6-methyl-3-hydroxypyridine is contained and excreted in large quantities in the urine. Metabolite IV is a glucuronic conjugate with 2-ethyl-6-methyl-3-hydroxypyridine. Metabolite V is a glucuronic conjugate with 2-ethyl-6-methyl-3-hydroxypyridine phosphate. APPLICATION OF MEXIDOL IN NEUROLOGY AND PSYCHIATRY Mexidol is an effective means of anti-ischemic protection of the brain in cerebral strokes. The drug has a pronounced therapeutic effect in patients with acute cerebrovascular accidents, including patients with ischemic and hemorrhagic stroke located in the circulation zone of the internal carotid artery and its branches, as well as in the vertebrobasilar system. Mexidol, as a rule, is administered to patients in the first hours of admission to the clinic intravenously in a stream or intravenously drip and intramuscularly, in doses of 50 mg. up to 400 mg. once, from 50 mg. up to 900 mg. per day with a frequency of administration of 3. The duration of action of the drug is about 4 hours. During the same time, the drug is detected in the blood of patients. One of the most significant manifestations of the effect of Mexidol when included in the complex therapy of cerebral stroke is a significant decrease in the daily mortality of patients in the acute period of stroke, as well as a tendency to an overall decrease in mortality in this disease. In the acute period of cerebral stroke, the mortality rate of patients was -31.5% for those taking Mexidol, and -52.5% without it; The bed days also decreased significantly: 38.2±2.7 with Mexidol and 45.2±4.0 days without Mexidol (B.A. Spasennikov). When using Mexidol in the treatment of cerebral stroke, first of all, a more rapid regression of neurological symptoms, assessed on the Matthew scale, is observed. Thus, in patients who are in in serious condition at the time of admission to the clinic, Matthew’s score at the end of the acute period (21 days) was 51.5±2.1, and after treatment with Mexidol it significantly increased to 59.7±1.0. When treating patients with Mexidol, the dynamics of improvement in motor functions, revealed when using the ADL index, was also indicative. So, after 21 days this indicator was 76.6±3.1 in patients using Mexidol, and in the group of patients without using Mexidol it was 63.2±4.6 (the difference is significant at P< 0,05). По данным ЭЭГ эффект Мексидола выявляется в виде повышения мощности спектра и активации быстроволновой ритмики. По результатам ультразвуковой плерографии магистральных сосудов мозга объемный кровоток в магистральных артериях головы после введения Мексидола увеличивается на 25-40 %. Мексидол оказывает церебральный вазодилятационный эффект, снижает показатели мозгового сосудистого сопротивления, существенно увеличивает пульсовые колебания мозговых сосудов и способствует гемодинамическим сдвигам, обеспечивающим отток крови в мозговые вены, не оказывая при этом существенного влияния на системное артериальное давление. У больных, получавших Мексидол, отмечается существенный регресс расстройств сознания при их оценке по платам Глазго-Питтсбург и А.Н. Коновалова. У этих больных значительно быстрее и отчетливее, в более ранние сроки восстанавливаются функции двигательной сферы, наблюдается положительная динамика в восстановлении координации движений. Мексидол заметно улучшает субъективное состояние больных, уменьшая проявления вегетативной дисфункции (чувство страха смерти, головные боли, колебания настроения, сердцебиения и т.д.). Под воздействием Мексидола редуцируются признаки вазомоторной нестабильности, гипертермия; потливость, тахикардия и др., уменьшается или устраняется psychomotor agitation, sleep improves significantly. Mexidol is highly effective in the treatment of dyscirculatory encephalopathy (DE), which is defined as a progressive multiple diffuse small-focal lesion of the brain of vascular origin and is characterized by ischemic-hypoxic damage to neurons, a progressive decrease in energy processes, activation of lipid peroxidation processes, and disruption of ionic homeostasis. Under these conditions, Mexidol, which has a normalizing effect on cerebral metabolism and fine neurochemical regulation, is of particular value. Cerebroprotective therapy with Mexidol differs from traditional effects on homeostasis and hemodynamics in the safety of use, the possibility of long-term use, and the ability to influence different levels and types of neurological and mental disorders. Mexidol in ampoules (5% solution) is used intravenously by stream, drip or intramuscularly in a dose of 2 to 3 mg/kg once, from 100 to 1000 mg per day (1-3 injections). The course of use of the drug was 6-14 days. Mexidol has a therapeutic effect in patients with DE of all three stages. The drug causes a decrease in complaints of headaches of a frontotemporal localization of a compressive nature and pain of a diffuse localization of a dull, aching nature, combined with a feeling that the ears are stuffed with cotton. Under the influence of Mexidol, regression of symptoms is observed in patients with complaints of flickering spots, the appearance of a grid, fog before the eyes, and noise in the head decreases; After a course of treatment with Mexidol, there was a statistically significant improvement in the main indicators of neuropsychological tests: an increase in the number of words learned, an increase in accuracy, quality and pace of work, a decrease in the number of errors, this indicates that Mexidol improves memory. Along with this, Mexidol reduces the feeling of fatigue, weakness, eliminates the feeling of anxiety and fear that arises in specific situations, and also has a therapeutic effect in sleep disorders of a presomnic, post-somnic and especially intrasomnic nature, increases the coefficients social adaptation. Mexidol provides positive influence on patients who have vestibular disorders, reducing uncertainty when walking, non-systemic dizziness, a feeling of loss of balance when walking. Mexidol reduces the phenomena of hyperesthesia and senestopathy; patients do not experience progression of oral automatism reflexes or smoothness of the nasolabial fold. The greatest dynamics during therapy with Mexidol are such symptoms as decreased performance, motor activity, dizziness, headache, memory impairment, anxiety, social maladjustment. Subjective and objective positive effects during treatment with Mexidol are observed, as a rule, by the end of the week of therapy. Echopulsography of intracranial arteries and veins after intravenous administration of Mexidol showed that already 30 minutes after the injection and for 4-6 hours, there is an increase in the amplitude (on average by 25.5%) of pulse oscillations of the cerebral vessels and the outflow of blood into the cerebral veins is facilitated. Under the influence of Mexidol, an increase in linear and volumetric blood flow in the extracranial regions is observed main arteries head, which is recorded within 6 hours after administration of the drug. Registration of rheoencephalography after a course of treatment with Mexidol revealed normalization of waveforms in 67% of patients, and improvement in venous outflow in 38%. There is an increase in pulse blood supply in the external carotid artery system and in the vertebrobasilar system, with its initially low level, and normalization of the tone of small arteries and veins in both vascular systems. Mexidol causes normalization of the EEG of patients with DE, which is expressed in an increase in the total power of the spectrum due to the alpha and beta ranges without a significant change in the slow wave part of the spectrum. In patients receiving Mexidol, the increased content of hemoglobin and leukocytes decreases, blood viscosity decreases, cholesterol levels decrease, and the lecithin-cholesterol ratio increases. Thus, Mexidol has a pronounced therapeutic effect in patients with discirculatory encephalopathy of stages 1, 2 and 3. Under the influence of Mexidol, remission or regression of neurological syndromic deficit is observed. As a result of treatment with Mexidol, 64% of patients showed a marked improvement in their condition, 32% had a moderate improvement, 20% had a slight improvement, and 16% had no effect. A comparison of the clinical effectiveness of Mexidol and known drugs showed that the index of overall effectiveness in the treatment of DE was 2.05 for Mexidol. for Cavinton, Trental and Sermion -2.1, Arsdergin -1.8. Mexidol is effective in patients with vegetative-vascular dystopia with symptoms of autonomic crises of a sympatho-adrenal nature, in whom improvement occurred within 5-14 days after the start of treatment. The intensity and frequency of headaches decreased, vasoactive imbalance and excitability decreased, and sleep improved. In 13% of patients, vegetative crises completely stopped and did not reappear over the next 2-3 months. Mexidol has a positive effect in patients with mental pathology of late age, especially with atherosclerotic dementia, in whom Mexidol was administered intramuscularly (patients received 100 mg for the first 5 days, and 300 mg daily for the remaining days, course - 3 weeks). Mexidol had a positive effect on memory, especially on current events, improved concentration, learning instructions, caused a decrease in headaches and symptoms of anxiety and depression. The degree of dysarthria and tearfulness in patients decreased. In some patients, dizziness completely disappeared, a confident gait appeared, and asthenia decreased. In some patients with initial manifestations senile-atrophic process and in patients with atherosclerotic dementia after treatment with Mexidol, there was a “clearing” in the head, an increase in activity, and an improvement in mood. Thus, the use of Mexidol improves intellectual-mnestic activity in patients with age-related organic weakening processes, mainly in patients with atherosclerotic dementia, helping to improve concentration, follow instructions, memory for the present, reduce headaches, dizziness, tearfulness, dysarthria, and increase activity . Mexidol has a pronounced positive effect in the treatment of chronic neuroleptic syndrome with symptoms of tardive dyskinesia and subacute neuroleptic syndrome. Before treatment with Mexidol, all patients received active therapy for neuroleptic syndrome with the drugs cyclodol, norparkin, midantan, tiapride, cerucal, tremblex, detoxification therapy with intravenous administration of nootropil, vitamins B and C, which was assessed as ineffective. Mexidol had a pronounced antiparkinsonian and vegetotropic effect in these patients who were difficult to treat. The effect of Mexidol began to manifest itself already from the 2-3rd day of therapy and consisted of a decrease in the severity of oral-lingual hyperkinesis, which completely disappeared by the 7-14th day of treatment, then, under the influence of the drug, a decrease in limb tremor, stiffness, hypokinesia and hypomimia was noted, it improved, became more confident, free gait of patients, which ceased to be shuffling and mincing. The phenomena of orthogatism and dizziness decreased and disappeared, there was a tendency to normalize blood pressure with drug-induced hypotension, and Mexidol had no effect on normal blood pressure, weakness, lethargy, and dizziness decreased. The antiparkinsonian effect of Mexidol persisted for another 3-5 days after its discontinuation. Mexidol also has the ability to overcome the body's resistance to the effects of psychotropic drugs. Mexidol for this pathology was used at a dose of 300-500 mg per day with a treatment duration of 2-4 weeks. The effect of Mexidol began to appear already on the 3rd day of administration. Patients noted an improvement in the appearance, color and turgor of the skin, appetite, a decrease in lethargy, weakness, dizziness, dry mouth, and they became less lethargic. Against the background of Mexidol, it was possible to increase the doses of antidepressants and antipsychotics by 1.5-2 times without the occurrence of side effects. In a number of cases, the administration of previously ineffective drugs against the background of Mexidol made it possible to overcome the body's resistance and caused a significant decrease in depressive disorders and improvement in condition. In neurotic and neurosis-like conditions, Mexidol has a distinct tranquilizing effect, combined with a vegeto-normalizing effect. The therapeutic effect of Mexidol was most fully manifested in patients with neuroses and organic damage to the central nervous system with asthenic and astheno-vegetative disorders. The drug was effective and well tolerated by elderly patients. In 6 patients with asthenic disorders, there was a reverse development of anxiety and emotional stress against the background of Mexidol was accompanied by a peculiar activation with an increase in the background mood, a reduction in the actual asthenic symptoms . The tranquilizing effect of Mexidol is comparable in power to the effect of uxepam. Mexidol has a positive effect on sleep, restoring its duration and depth. The effect of Mexidol appears after 3-7 days of therapy. According to its spectrum of action, Mexidol can be classified as a daytime tranquilizer, which is effective both in hospital and outpatient settings, as well as in the elderly. Mexidol has shown high effectiveness in the treatment of alcohol withdrawal syndrome with somato-neurological and mental symptoms. The dose of Mexidol was 100-400 mg per day intramuscularly with a course duration of 5-7 days (against the background of conventional detoxification agents). Mexidol is an effective remedy for the rapid relief of alcohol withdrawal syndrome with a wide range of effects, both on its psychopathological components and on vegetative-vascular manifestations. The effect of Mexidol is observed within 1-1.5 hours after administration of the drug, and a persistent improvement in the condition occurs after 2-3 days. Patients experience a feeling of enlightenment, clarity in the head, headaches disappear, the process of concentration and comprehension when reading literature improves, anxiety, unaccountable fear, internal tension decrease, relaxation and a comfortable state appear, nightmares disappear, hypnotic hallucinations disappear, dreams become alcohol-free topics, sleep disorders disappear. Patients note the appearance of vigor and activity. Along with this, under the influence of Mexidol, alcohol motivation was significantly suppressed. Side effects. Comparison with cerebroprotective and psychotropic drugs. Mexidol is well tolerated by patients and causes only isolated side effects, which quickly disappear on their own or when the drug is discontinued. Of the hundreds of patients treated with Mexidol, side effects occurred in exceptional cases. Two patients with discirculatory encephalopathy experienced nausea and dizziness a few minutes after the intramuscular injection of Mexidol, which went away on their own. Two patients with alcoholism experienced bitterness and dry mouth, dizziness, and weakness, which quickly disappeared when the drug was discontinued. In three patients with resistant depression combined with manifestations of chronic neuroleptic syndrome, after the first two or three injections a slight drowsiness appeared, which then disappeared on its own. One patient with neurosis, at the beginning of therapy, had a pinpoint rash on the skin of the forearms, not accompanied by itching and peeling, which self-reduced within three days with continued therapy. The insignificance of side effects makes Mexidol stand out among the known neuroprotective, nootropic and tranquilizing agents. The arsenal of drugs used in modern medicine that improve cerebral circulation and are used in injection form is quite limited and includes pentoxifylline (Trental), vinpocetine (Cavinton), nicergoline (Sermion), dihydroergotoxin (Redergan). Cinnarizine (stugeron), flunarizine, nimodipine are used in the form of tablets and capsules. A significant drawback of these known drugs, which in many cases limits their use, is the significant number and frequency of side effects. Pentoxifylline (trental) causes headache, dizziness, tachycardia, facial flushing, palpitations, angina pectoris, arterial hypotension, nervousness, drowsiness or insomnia, bleeding from the vessels of the skin and mucous membranes, urticaria, skin rashes, itching, nausea, vomiting, a feeling of heaviness in the epigastrium, increased fragility of nails, changes in body weight, swelling, and in case of an overdose of the drug, convulsions, loss of consciousness, and fever may occur. In this regard, contraindications to the use of trental are acute myocardial infarction, massive bleeding, cerebral hemorrhage, retinal hemorrhage, severe atherosclerotic damage to the blood vessels of the brain and heart, severe violations heart rate, pregnancy, lactation. Characteristic side effects of vinpocetine (Cavinton) are a decrease in blood pressure and tachycardia, and contraindications to the use of the drug are coronary heart disease and severe forms of arrhythmias. Nicergoline (sermion) causes arterial hypotension, dizziness, a feeling of heat and flushing, drowsiness and sleep disturbance. Side effects of dihydroergotoxin (redergin) are nausea, vomiting, a feeling of heaviness in the stomach, loss of appetite, blurred vision, hyperemia of the nasal mucosa, skin rash, orthostatic hypotension, and contraindications to the use of the drug are severe coronary heart disease, severe bradycardia and arterial hypotension . Thus, all drugs currently used to treat cerebrovascular accidents are associated with significant side effects. In conditions of oxygen and energy deficiency that occurs with cerebrovascular lesions of the brain, Mexidol, which has a normalizing effect on cerebral metabolism, on fine neurochemical regulation and has minimal side effects, is of particular value. Cerebroprotective therapy with Mexidol differs from traditional effects on homeostasis and hemodynamics in its safety of use, the possibility of long-term use, and the ability to influence various levels and types of neurological and mental disorders. In contrast to traditional drugs, Mexidol does not cause a decrease in blood pressure, hemodynamic or ECG disturbances, and does not affect the heart rate. The positive effects of Mexidol in comparison with well-known drugs are its therapeutic effect on vasomotor instability, reduction of autonomic dysfunction, reduction of tachycardia, hyperemia, sweating, etc. In addition, Mexidol has a restorative effect on the functions of the motor sphere, improving coordination of movements and reducing psychomotor agitation, improves sleep, eliminates nervousness. Thus, having a high therapeutic effect, Mexidol does not have the side effects characteristic of other neuroprotective drugs. In contrast to sodium hydroxybutyrate and seduxen, Mexidol does not change the rhythm and frequency of breathing, i.e. does not cause the cardiorespiratory depression inherent in these drugs. In contrast to noopropic drugs, when using Mexidol, there is no activating effect, sleep disturbances or increased convulsive readiness. In addition, Mexidol is significantly more effective than piracetam (nootropil). In comparison with benzodiazepine tranquilizers (seduxen, elenium, oxazepam, lorazepam, phenazepam, etc.), Mexidol does not have a muscle relaxant effect even in doses exceeding the average therapeutic anxiolytic dose by 4-5.5 times and does not cause such manifestations as impaired coordination movements, decreased muscle tone and muscle strength. Mexidol, in contrast to anxiolytics, does not have a sedative or amnesic effect, but, on the contrary, has a positive effect on memory, especially in conditions of impaired cognitive functions. With long-term administration of Mexidol and cessation of its use, there are no signs of withdrawal syndrome characteristic of benzodiazepine tranquilizers. Thus, Mexidol is a selective tranquilizer of “daytime” action, in which the anxiolytic and anti-stress effects are carried out without layering sedative, muscle relaxant and amnesic effects. Possessing a high therapeutic effect, Mexidol does not cause side effects characteristic of known neuroprotective, nootropic and tranquilizing drugs, which indicates its safety and significantly expands the possibilities of use. Directions for use and doses Mexidol is prescribed intravenously (stream or drip), intramuscularly and orally. When administered intravenously, the drug should be diluted with water for injection or in physiological sodium chloride solution. For infusion administration physiological NaCl solution should be used. Mexidol is administered in a stream over 1.5-3.0 minutes, and dropwise at a rate of 80-120 drops per minute. The duration of treatment and the daily dose of the drug depend on the nosology of the disease and the severity of the patient’s condition. For the treatment of acute cerebrovascular accident, Mexidol is prescribed intravenously by drip of 400 mg (8 ml) in isotonic sodium chloride solution (100-150 ml) twice a day for the first 15 days in intensive care or a specialized neurological department (maximum daily dose 1600 mg) . Then 400 mg (8 ml) 1 time per day intravenously on a physiological NaCl solution daily for 15 days. In the future, it is recommended to administer Mexidol intramuscularly at a dose of 200 mg (4 ml) once a day for 10-15 days. In subsequent complex drug therapy, it is advisable to include a tablet form of the drug, 0.25-0.5 g/day for 4-6 weeks. The daily dose is distributed into 2-3 doses during the day. For the treatment of dyscirculatory encephalopathy (both against the background of cerebral atherosclerosis and against the background of hypertension):

In the decompensation phase, Mexidol is administered:
- either 400 mg (8 ml) intravenously in drops per 100 ml of isotonic NaCl solution daily for 10-15 days;
- either 200 mg (4 ml) intravenously in 16.0 ml of water for injection or in isotonic sodium chloride solution (16.0 ml) twice a day, for 10-15 days. Then the drug is administered intravenously in a stream of 100 mg (2 ml) per 10.0 ml of isotonic sodium chloride solution, daily, for a course of 10 days. Or 200 mg (4 ml) intramuscularly, daily for 10 days. Subsequently, oral administration of Mexidol 0.125 g three times a day is recommended for 4-6 weeks.

In the subcompensation phase, Mexidod is used:
- either 200 mg (4 ml) intravenously in a stream of 16.0 ml of physiological NaCl solution (or 16.0 ml of water for injection), daily, for 10-15 days;
- either 200 mg (4 ml) intramuscularly, twice a day, for 10-15 days. Then you can continue treatment with a tablet form of 0.125 g three times a day, for a course of 4-6 weeks. For course prevention of dyscirculatory encephalopathy (compensation phase), Mexidol is recommended to be administered:
- either 100 mg (2 ml) intravenously in a stream of 10.0 ml of physiological NaCl solution, daily for 10 days;
- either 200 mg (4 ml) intramuscularly, daily, for a course of 10 days. Subsequently, it is advisable to take the tablet form, 0.125 g three times a day, for 2-6 weeks (in both cases - with intravenous and intramuscular administration);
- or initially, a course of prophylaxis can be started with the use of a tablet form of 0.125 g three times a day, for at least 4-6 weeks. For vertebrobasilar insufficiency due to osteochondrosis cervical region spine Mexidol is used:

In the decompensation phase:
- either 400 mg (8 ml) intravenously, in 100 ml of physiological NaCl solution, daily, 10 days;
- either 200 mg (4 ml) intravenously in a bolus of 16.0 ml of isotonic sodium chloride solution, twice a day, for 10 days; Subsequently, intramuscular administration of 200 mg (4 ml) is recommended for 10-15 days. Upon completion of intramuscular injections, switch to oral administration of the drug at 0.125 mg three times a day, for a course of 2-6 weeks.

In the subcompensation phase:
- either 200 mg (4 ml) of Mexidol is administered intravenously, in 16.0 ml of isotonic sodium chloride solution, for 10 days;
- either 200 mg (4 ml) intramuscularly, twice a day, 10 days. In the future, it is advisable to prescribe the tablet form in the doses described above. In the acute period of traumatic brain injury, the prescription of Mexidol is pathogenetically justified, since, in addition to its cerebroprotective properties, its anticonvulsant activity and potentiation of the action of dehydration agents are of great importance. Recommended doses of the drug:
- in the acute period - 200 mg (4 ml) intravenously, per 16.0 ml of isotonic sodium chloride solution, twice a day, 10-15 days;
- in the subacute period - 200 mg (4 ml) intravenously in a bolus per 16.0 ml of isotonic sodium chloride solution, daily for 10 days; or 200 mg (4 ml) intramuscularly, twice a day, 10-15 days. During the rehabilitation period, it is recommended to take the tablet form 0.125 g three times a day for 4-6 weeks. The administration of the drug is very effective in the treatment of dysmetabolic, and, first of all, diabetic encephalopolyneuropathies. Mexidol, used for diabetes mellitus, improves the course of the disease itself, and also improves the uptake of glucose by cells in conditions of insulin resistance. It is recommended to administer the drug 200 mg (4 ml) intravenously in a bolus, per 16.0 ml of physiological NaCl solution, twice a day, for 10-15 days. In the future, 100 mg (2 ml) is administered intramuscularly daily for 15-30 days. Upon completion of parenteral administration, switch to tablet form - 0.125 g three times a day, for at least 4-6 weeks. Considering the lack of a direct stimulating effect on the cerebral cortex, and having a pronounced anticonvulsant effect, Mexidol can also be used in the treatment of epilepsy. The drug enhances the effect of anticonvulsants, which allows, when prescribed, to reduce the doses of traditional medications used and, thereby, reduce their side effects. Mexidol is recommended to be administered 100 mg (2 ml) intravenously in a bolus of 18.0 ml of isotonic sodium chloride solution (or in the same amount of water for injection), twice a day, for 15 days. Then the drug is administered intramuscularly at 100 mg (2 ml) daily for 15 days. Degenerative-dystrophic lesions of the central nervous system. Mexidol has a pronounced positive effect in the treatment of chronic neuroleptic syndrome with symptoms of tardive dyskinesia and subacute neuroleptic syndrome. The drug reduces the severity of oral-lingual hyperkinesis, reduces limb tremors, stiffness, hypomimia and hypokinesia, improves motor functions sick. In addition, it potentiates the effect of antiparkinsonian drugs, which makes it possible to reduce the doses of drugs used and reduce their side effects. For the treatment of degenerative-dystrophic lesions of the central nervous system, Mexidol is recommended to be used 200 mg (4 ml) intravenously in a stream of 16.0 ml of isotonic sodium chloride solution, twice a day, for 10 days. Then the drug is administered intramuscularly at 200 mg (4 ml), daily, for 15 days. In the next 4-6 weeks, it is advisable to prescribe the tablet form - 0.125 g three times a day. Autonomic dysfunction syndrome, neurotic and neurosis-like states. Mexidol has shown its high effectiveness in vegetative-vascular dystonias, especially those of the paroxysmal type. It has a vegetative-normalizing and distinct tranquilizing effect in neurotic and neurosis-like conditions. Dosage regimen of the drug: 100-200 mg (2-4 ml) intravenously in a bolus of 10.0-16.0 ml of isotonic sodium chloride solution, daily for 10 days. It is possible to administer the drug intramuscularly at 200 mg (4 ml), daily, for 15 days. After injections, it is advisable to prescribe a tablet form of 0.25-0.50 g per day. The daily dose is distributed into 2-3 doses. The course of treatment is 2-6 weeks. In this case, the course therapy is completed gradually, reducing the dose of the drug over 2-3 days. Parasomnic disorders. Mexidol has a positive effect on sleep, restoring its duration and depth, while helping to restore the correct sleep rhythm. This is combined with the absence of sedation effects when taking the drug during the day. In this case, the drug is recommended to be administered intramuscularly, 100-200 mg (2-4 ml), daily for 15-20 days. Then use the tablet form of 0.125 g three times a day for 4-6 weeks. Before discontinuation, the dose of the drug is reduced gradually over 2-3 days. Memory disorders and intellectual disability in the elderly. Mexidol is effective drug for revitalization of elderly people. The drug has positive action on hypomnesia, increased distractibility and difficulty concentrating, improves the ability to concentrate and count, improves short-term memory for current events and long-term memory for the past. Recommended dosage regimen: 100-200 mg (2-4 ml) intramuscularly (depending on the degree of intellectual disability) for 10-15 days, then the drug is given orally at 0.125 g three times a day for at least 4-6 weeks Such courses are repeated every 5-6 months. Periods of extreme stress. Mexidol has a pronounced ability to improve mental and physical performance, especially under conditions of extreme influences. In such cases, it is advisable to start with intravenous administration of 200 mg (4 ml) intravenously in a stream, per 16.0 ml of isotonic sodium chloride solution, daily for 10-15 days. Then the drug is administered intramuscularly at 200 mg (4 ml) per day for 10 days, followed by a transition to taking the tablet form at 0.25-0.50 g per day; course of treatment - 2-6 weeks. It is possible to switch to the tablet form immediately after intravenous administration. Exogenous-organic diseases of the brain. The causes of exogenous-organic brain damage are: previous traumatic brain injuries, intoxication (excluding alcohol), neuroinfections, as well as combinations of these factors. Patients with exogenous-organic diseases are known to have poor tolerance to a number of drugs. Mexidol, as studies have shown, is not one of them. When used, there is a clear positive effect on existing neurological deficits in this category of patients. Recommended dosage regimen: intravenous bolus of 200 mg (4 ml) per 16.0 ml of isotonic sodium chloride solution, daily, for 10-15 days; then the drug can be administered intramuscularly at 100-200 mg (2-4 ml) per day for 10-15 days, or switch to the tablet form at 0.125 g three times a day for 4-6 weeks. Intoxication with ethyl alcohol. Considering the antihypoxic, antioxidant, tranquilizing and hepatoprotective effects of Mexidol, it can be used as part of complex therapy to relieve ethyl alcohol intoxication. Mexidol prevents and weakens the toxic effects of alcohol. Dosage regimen: 400 mg (8 ml) intravenously in 150.0 ml of isotonic sodium chloride solution twice a day for 3 days; then 200 mg (4 ml) intravenously in a bolus with 16.0 ml of physiological NaCl solution, twice a day, for 7 days. If necessary, treatment can be continued using the tablet form of the drug, 0.125 g three times a day for 2-6 weeks. Alcohol withdrawal syndrome. Mexidol is effective as a means for relieving alcohol withdrawal syndrome with somato-neurological and mental symptoms due to its pronounced antioxidant and tranquilizing effects. When comparing the speed of the relief effect of Mexidol in relation to individual symptoms of alcohol withdrawal syndrome with the effectiveness of traditional detoxification agents, a significant advantage of this drug was established. Mexidol is an effective remedy for the rapid relief of alcohol withdrawal syndrome with a wide range of effects, both on its psychopathological components and on vegetative-vascular manifestations. The injectable form, in contrast to the tablet form, turns out to be more effective in relation to affective pathology, eliminating anxiety in a significantly more short time. Recommended dosage regimen: 200 mg (4 ml) intravenously in a bolus, per 16.0 ml of isotonic NaCl solution, daily, for 10-15 days, then it is possible to switch to intramuscular administration of the drug at a dose of 200 mg (4 ml), daily, for 10 days, followed by switching to the tablet form, 0.125 g three times a day, 4-6 weeks. In some cases, a combination of only intramuscular administration of the drug (in the described dosages) and tablet form is possible. It is also possible to use only the tablet form at a dose of 0.5 g per day (2 tablets twice a day) throughout the entire period of existence hangover syndrome. Anxiety disorders in neurotic and neurosis-like conditions. For anxiety disorders - psychogenic (neurotic), for endogenous diseases, for organic brain damage of traumatic, intoxication and vascular origin, Mexidol, used as an anxiolytic agent, is most effective for generalized anxiety and anxiety-asthenic conditions that are simple in structure. The anxiolytic effect of the drug, combined with an activating component and a vegetative-normalizing effect, contributes to the rapid reduction of emotional stress, anxiety, asthenic and autonomic disorders, and sleep disorders. For the treatment of these disorders, the drug is used intramuscularly in a daily dose of 200 - 400 mg, divided into 2 doses for 14 - 30 days or orally 0.25 g (2 tablets of 0.125 g) twice a day for at least 4 weeks Mild cognitive disorders of atherosclerotic origin. For mild cognitive impairment of vascular origin, including those developing in elderly patients, the use of Mexidol has a positive effect on dysmnestic disorders, reduces the severity of cerebroasthenic symptoms and emotional instability. The drug is used intramuscularly at a dose of 200 - 400 mg per day, divided into 2 doses for 14-30 days or orally at 0.25 g (2 tablets of 0.125 g) for 4 weeks. Acute intoxication with antipsychotic drugs (neuroleptics). In acute intoxication with neuroleptics with symptoms of neuroleptic syndrome, Mexidol causes a decrease in the severity of hyperkinesis, tremor, and muscle rigidity. When used in combination with antiparkinsonian drugs, Mexidol potentiates their effect. In case of acute intoxication with neuroleptics, the drug is administered intravenously at a dose of 50 - 300 mg per day for 7-14 days. Intellectual-mnestic disorders of various origins. In organic psychosyndrome caused by chronic disorders cerebral circulation, traumatic brain injuries, neuroinfections and intoxications, initial manifestations of senile-atrophic processes, increased manifestations of mental aging, Mexidol therapy begins with parenteral administration of the drug 200 mg (4 ml) intramuscularly, daily, for 10-15 days. In the future, they switch to the tablet form of the drug - 0.125 g three times a day, for at least 4-6 weeks. Correction of insulin resistance. The inclusion of Mexidol in the complex therapy of diabetes mellitus makes it possible to achieve compensation for the disease, reduce the doses of glucose-lowering drugs, stop the progression of late complications and, thus, improve the quality and prognosis of life. The use of Mexidol is especially effective for correcting chemical homeostasis in the group of diabetic patients whose hypoglycemia cannot be stabilized by traditional therapy and who have high levels of atherogenic lipids in the blood, severe neuropathy, impaired microcirculation, and hemostasis. Mexidol is especially necessary in the prevention of late complications of diabetes: retinopathy, nephropathy, diabetic foot syndrome. At the same time, it is possible to correct tissue trophism by stimulating microcirculation, detoxification, enhancing oxidative processes in the energy cycle. A decrease in glycemia when Mexidol is included in the complex therapy of diabetes helps to reduce the percentage of purulent-septic complications in surgical interventions. Positive effect The use of Mexidol in the clinic is observed with short courses of treatment (5 - 7) days at a dose of 100 - 200 mg per day. The dose is selected individually depending on the biochemical profile of lipid and carbohydrate metabolism. Complex therapy of acute purulent-inflammatory processes of the abdominal cavity. In acute destructive pancreatitis and peritonitis, Mexidol is prescribed on the first day, both in the preoperative and postoperative periods. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. Discontinuation of the drug should be done gradually, only after a stable positive clinical and laboratory effect.
- For acute edematous (interstitial) pancreatitis, Mexidol is prescribed 100 mg (2 ml) three times a day intravenously, in an isotonic sodium chloride solution.
- Mild severity of necrotizing pancreatitis - 100-200 mg (2-4 ml) three times a day intravenously (in isotonic NaCl solution).
- Severe necrotizing pancreatitis - the drug is administered in a pulse dosage of 800 mg (16 ml) on the first day, with a double administration regimen; then 300 mg (6 ml) twice a day with a gradual reduction in the daily dose.
- Extremely severe course - at an initial dosage of 800 mg/day (16 ml) for persistent relief of manifestations of pancreatogenic shock, upon stabilization of the condition, 300-400 mg (6-8 ml) twice a day intravenously (in isotonic sodium chloride solution) With a gradual reduction in daily dosage. In complex therapy of peritonitis, Mexidol is administered in a dosage of 200-300 mg (4-6 ml) three times a day intravenously in an isotonic sodium chloride solution during the first 3 days, then 200 mg (4 ml) per day with a gradual decrease daily dose. Use in dental medical practice. The rationale for the use of Mexidol in the complex therapy of chronic generalized periodontitis (CGP) was the ability to inhibit free radical oxidation and increase the activity of the antioxidant system. To achieve optimal effects, it is advisable to use both local and parenteral route administration of Mexidol. For mild CGP, Mexidol is prescribed according to the following regimens. Locally in the form:
- rinsing with 2 ml of 5% solution for injection 3 times a day, for 12-14 days. Method of preparation: dilute 1 ampoule of the drug with warm boiled water and rinse for 5 minutes.
- or applications of 2 ml of 5% Mexidol solution 2-3 times a day, for 12-14 days. Method of preparation: open 1 ampoule of the drug and moisten a piece of sterile gauze or bandage, folded in 4 - 6 layers, with the solution. Apply along the outer perimeter of the gingival sulcus for 20 minutes. Additionally, it is recommended to brush your teeth with toothpaste from the "MEXIDOL dent" series 2 times a day for 3-5 minutes. Orally: 1-2 tablets orally 2 times a day, for 12-14 days. For moderate and severe degrees of CGP, Mexidol is prescribed according to the following regimens. Locally in the form:
- rinsing (2 ml of 5% solution 3 times a day) for 12-14 days.
- or applications (2 ml of 5% solution 2-3 times a day) for 1214 days. If there is a periodontal pocket, use:
- Installation of 2 ml of 5% solution for injection. Method of preparation: open 1 ampoule of the drug and moisten the turunda with the solution, which is placed in the periodontal pocket for 20 minutes. Parenteral: intramuscularly 2 ml of 5% solution (100 mg) 1 time per day for 12-14 days Oral: 1-2 tablets (0.125 - 0.25 g) 2 - 3 times per day for 12-14 days. Additionally, it is recommended to brush your teeth with toothpaste from the "MEXIDOL dent" series 2 times a day for 3-5 minutes. Contraindications The use of Mexidol is contraindicated in acute disorders of liver and kidney function. Hypersensitivity or intolerance to the drug. Side effects May be observed: from the digestive system, rarely - nausea, dry mouth. Adequate and strictly controlled clinical trials The safety of the drug during pregnancy, lactation (breastfeeding) and children has not been studied. Interaction with other drugs Not installed. The drug is combined with almost all drugs used in complex therapy for the specified nosologies. Mexidol potentiates the effect of anticonvulsants, tranquilizers, antiparkinsonian drugs, and analgesics. The drug reduces the toxic effects of ethyl alcohol.

Active ingredient Mexidol is ethylmethylhydroxypyridine succinate(2-ethyl-6-methyl-3-hydroxypyridine succinate). An injection solution (50 g/l) or tablets containing 125 mg of active substance are available. This is a domestic drug, one of the drugs- antioxidants new generation.

As excipients, the Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 l).

The excipients in the tablets are magnesium stearate, sodium carboxymethylcellulose (otherwise known as carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Release form

Mexidol tablets are available in packs of 10 tablets and in plastic jars of 90 tablets.

Mexidol injection solution is available in clear or dark glass ampoules with a break point of 2 ml, which are packaged in a strip pack of 5 pieces, and boxes of 5 or 10 ampoules.

pharmachologic effect

Ethylmethylhydroxypyridine succinate is a substance that protects membranes and reduces the level of free radicals in the body. It has an antihypoxic (saturates the blood with oxygen), anti-stress, anticonvulsant effect. This medicine is a nootropic substance (Greek noos - mind, reason + tropos - direction), improves memory, mental activity, stimulates learning, levels negative impacts from the outside on these processes. Restores the sleep-wake cycle, reduces the rate of degenerative processes in the brain.

Mexidol enhances the effect of tranquilizers, neuroleptics and antidepressants, as well as substances with hypnotic and anticonvulsant effects. This allows you to reduce their doses and remove most side effects.

Indications

Mexidol is used as an antioxidant drug.

Neurology:

• acute cerebral circulatory disorders and dyscirculatory encephalopathy (otherwise known as cerebral atherosclerosis);
• cognitive problems of atherosclerotic origin (impaired speech, memory, attention, intelligence and other symptoms associated with the development of atherosclerosis).

Psychiatry:

• relief of withdrawal symptoms (otherwise known as withdrawal) in alcoholism;
• intoxication with antipsychotics (drugs intended to treat psychosis);
• anxiety in neuroses.

Surgery: used for acute purulent-inflammatory processes of the peritoneum (necrotizing pancreatitis and peritonitis) as part of a complex of therapeutic treatments.

Mexidol - instructions for use

Prescribe one or two tablets three times a day. The initial dose is 1-2 tablets twice a day, the maximum dose is two tablets three times a day (600 mg). The course of treatment is 2-6 weeks, for the treatment of alcoholism - 5-7 days. Treatment is discontinued gradually, reducing the daily dose to zero over two to three days.

In dentistry, Mexidol is used topically in the form of applications and rinses with a 5% injection solution in the oral cavity and periodontal pocket. Perform the procedure 2-3 times a day until the expected therapeutic effect.

The use of injection solution is in the appropriate section.

Contraindications

The drug should not be used by persons with hypersensitivity to the active substance or auxiliary components, as well as in case of acute dysfunction of the liver and kidneys.

Mexidol 5

A 5% solution of Mexidol is available in 2 ml clear or dark glass ampoules. Ampoules of 5 pieces are in contour packs. The box contains one contour package (5 ampoules).

Used for intravenous injection, drip or jet administration. Solvent – ​​injection water. Jet administration is 5-7 minutes, and drip administration is 60 drops per minute. The dose is selected individually.

At the beginning of treatment, 0.05-0.1 g is administered 1 to 3 times a day, after which the dose is slowly increased. You can take no more than 0.8 g per day.

In older patients, intramuscular injections of 0.1-0.3 g per day are used to treat dementia.

Mexidol toothpaste is available in several varieties:

• MEXIDOL dent Complex – against caries.
• MEXIDOL dent Sensitive – sensitive teeth.
• MEXIDOL dent Professional White – for professional whitening.
• MEXIDOL dent Fito – against bleeding.
• MEXIDOL dent Aktiv – against gum inflammation.

The paste is produced by the Russian pharmaceutical company Pharmasoft. In addition to toothpaste, the company also produces a dental elixir for mouth rinsing.

These are not only hygiene products. The Mexidol line of oral hygiene products has a pronounced therapeutic effect in the presence of gingivitis, stomatitis, periodontitis, caries.

Mexidol White (toothpaste)

MEXIDOL dent Professional White toothpaste is intended for teeth whitening. Suitable for patients with sensitive teeth.

Cleaning teeth from plaque occurs with the help of papain. Contains hydroxyapatite and calcium citrate, which penetrate well into tooth enamel after plaque removal. Mexidol, which is part of the paste, relieves inflammation of the mouth and gums, eliminates bleeding.

Side effects

The side effects of Mexidol are minor. The drug has low toxicity. Even in large doses, it does not affect involuntary motor activity, does not change the coordination of movements, does not affect reflexes, rectal temperature, and does not cause drowsiness. In animals, its use does not change orienting-exploratory behavior. Even in high doses, the medicine does not produce a muscle relaxant effect and improves memory.

The drug does not have a negative effect on the liver, does not affect blood pressure, hemodynamics, respiratory rhythm, blood composition and heart rate.

Side effects were identified in individual animals, and were expressed in a decrease in motor activity and failures in coordination of movements. These effects were observed when large doses were administered (300 mg/kg of the drug), as well as when the drug was administered into the peritoneum in doses above 400 μ/kg.

People with a large overdose experience nausea, drowsiness, and dry mouth mucous membranes, which go away on their own. In case of individual hypersensitivity to the components of the drug, allergic reactions may occur.

Mexidol during pregnancy

There have been no reliable studies on the use of Mexidol in pregnant women. Some instructions indicate that it is contraindicated during pregnancy.

Mexidol for children

The use of Mexidol in pediatrics is indicated in the treatment of purulent neuroinfections, traumatic brain injuries, as well as for emergency care in case of childhood traumatic brain injuries (100 mg once). For children, the drug should be prescribed by a doctor who will monitor the child throughout its use. There are no statistically reliable studies of the use of the drug in children.

Local application in dental practice occurs without complications.

Compatibility with other medications

This medicine can be used in conjunction with other psychotropic drugs, enhances the effect of benzodiazepines, carbamazepine and drugs for the treatment of Parkinson's disease, anticonvulsants, analgesics, tranquilizers. Compatible with all components of therapeutic treatment regimens in which it is used. Reduces the toxicity of ethyl alcohol.

Comparison with other drugs

Actovegin and Mexidol

The drugs have similar application and are often appointed jointly. Actovegin is produced on the basis of an extract from calf blood, so allergic reactions are more likely to develop to it. Improves nutrition and tissue regeneration. Unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and to treat the consequences of such disorders - trophic ulcers and angiopathy.

What's better than Mexidol?

Since the drug has recently appeared on the market, its research is ongoing. In the case of a particular patient, those remedies that give the maximum effect are always good. If there is no improvement within two to three days of using Mexidol, it is better to replace it with other drugs. There is no clear answer to the question of which drugs are better. The selection of a treatment regimen is individual and depends on the level of qualifications of the attending physician.

Mexidol or Mexiprim?

Mexiprim - German equivalent domestic drug Mexidol. Produced by the Stada Arzneimittel concern. It differs only in the excipients included in the shell and core of the tablets.

Mexidol or Cavinton?

The active ingredient of Cavinton is a semi-synthetic derivative of vincamine (devincan) contained in periwinkle - vinpocetine. It is a vasodilator used to improve blood circulation in the brain. Slightly reduces blood pressure, improves the supply of glucose and oxygen to the brain. It is also used in ophthalmology and the treatment of age-related diseases of the ENT organs.

Both drugs complement each other and are often used together in the treatment of cerebrovascular problems. It is not advisable to mix these drugs in one dropper; it is better to administer them separately.

Mexidol or Mildronate?

Mildronate (trimethylhydrazinium propionate) is a vasodilator, improves oxygen supply to tissues, increases humoral and tissue immunity, lowers blood pressure, and is used in the treatment of coronary artery disease. It can be prescribed together with Mexidol for withdrawal symptoms and disorders of the blood supply to the brain, since the drugs complement each other.

Mexidol or Neurox?

These two drugs are analogues and contain the same active ingredient.

Mexidol or Cortexin?

Cortexin contains an extract from bovine brain polypeptides. The choice of drug depends on the individual reaction of the patient’s body to it. Together, both drugs are used in the treatment of acute brain hypoxia in newborns. Prescribed only by the attending physician.

Mexidol or Nootropil?

The active ingredient of the drug Nootropil is piracetam. The drugs are often prescribed together to treat memory impairment, the consequences of ischemic stroke, alcoholism, and improving learning ability in children.

Mexidol and alcohol

Mexidol reduces the toxic effect of alcohol, removes it from the body, and is used to treat withdrawal symptoms (withdrawal) during recovery from alcohol addiction.

Synonyms and analogues

Synonyms:

• Mexidant;
• Mexico;
• Mexiprim;
• Mexicofin;
• Armadin.

Analogues:

• Medomexy;
• Mexipridol;
• Metostabil;
• Neurox;
• Cerecard.