Nazol – spray and drops for nasal congestion. An active assistant in the fight against runny nose...

Instituto de Angeli S.R.L. Instituto de' Angeli S.r.L. / Sagmel Inc. Sagmel Inc.

Country of origin

Italy Italy/USA UNITED STATES

Product group

Respiratory system

Vasoconstrictor drug for local use in ENT practice

Release forms

• 10 ml - polyethylene bottles (1) - cardboard packs 5 ml - low-density polyethylene bottles (1) - cardboard packs. 10 ml - low density polyethylene bottles (1) - cardboard packs. 15 ml - low density polyethylene bottles (1) - pack

Description of the dosage form

• Nasal drops 0.125% in the form of a clear solution, from colorless to light yellow color, without smell.

pharmachologic effect

A vasoconstrictor drug for local use in ENT practice, it is an alpha1-adrenergic receptor agonist (sympathomimetic). Renders vasoconstrictor effect due to stimulation of alpha1-adrenergic receptors in the nasal mucosa: reduces swelling, congestion and tissue hyperemia in the nasal mucosa, and also improves nasal patency respiratory tract

Pharmacokinetics

At local application systemic absorption of the drug is low.

Special conditions

In children under 1 year of age, the drug should be used strictly as prescribed by a doctor and no more often than every 6 hours. In children, the systemic absorption of phenylephrine and the associated risk of side effects is higher than in adults. Phenylephrine should not be prescribed to patients within 2 weeks of stopping MAO inhibitors, as they may enhance the adrenergic effects of sympathomimetics and increase the risk of side effects. of cardio-vascular system. Overdose There are no data on drug overdose. Symptoms: possible with systemic absorption - ventricular extrasystole, short paroxysms ventricular tachycardia, feeling of heaviness in the head and limbs, excessive increase in blood pressure, agitation. Treatment: intravenous administration of alpha-blockers short acting(phentolamine) and beta-blockers (for rhythm disturbances).

Compound

• 100 ml phenylephrine hydrochloride 0.125 g Excipients: benzalkonium chloride - 0.018 g, glycerol - 5 g, macrogol 1500 - 1.5 g, sodium hydrogen phosphate dihydrate - 0.226 g, potassium dihydrogen phosphate - 0.101 g, disodium edetate dihydrate - 0.02 g, purified water - 94.76 g, phenylephrine hydrochloride 1.25 mg Vsp harmful substances : benzalkonium chloride 50%, disodium ethylenediaminetetraacetic acid (disodium edetate), polyethylene glycol, glycerol, disodium phosphate, potassium phosphate, purified water

Nazol Baby indications for use

• To facilitate breathing through the nose during: - colds and flu; - hay fever or other allergic diseases upper sections respiratory tract, accompanied acute rhinitis or sinusitis.

Nazol Baby contraindications

• - diseases of the cardiovascular system (including coronary sclerosis, angina pectoris); - hypertensive crisis; - thyrotoxicosis; - diabetes; - hypersensitivity to the components of the drug. Use the drug with caution in children under 6 years of age.

Nazol Baby dosage

• 0,125 %

Nazol Baby side effects

• From the side of the central nervous system: headache, dizziness, tremor, sleep disturbance. From the cardiovascular system: palpitations, arrhythmia, increased blood pressure. Local reactions: sometimes - burning, tingling or tingling in the nose. Other: sweating, pallor.

Drug interactions

MAO inhibitors (procarbazine, selegiline), tricyclic antidepressants, maprotiline, guanedrel, guanethidine enhance the pressor effect and arrhythmogenicity of phenylephrine (with systemic absorption). Thyroid hormones increase (mutually with systemic absorption of phenylephrine) the associated risk of developing coronary insufficiency(especially when coronary atherosclerosis).

Overdose

possible with systemic absorption - ventricular extrasystole, short paroxysms of ventricular tachycardia, feeling of heaviness in the head and limbs, excessive increase in blood pressure, agitation

Storage conditions

• store in a dry place
• store at room temperature 15-25 degrees
• keep away from children
• store in a place protected from light

Information provided

Nasal drops 0.125% in a dropper bottle of 5, 10, 15, 30 ml.

pharmachologic effect

Nazol Baby drops, which can also be used for newborns, have vasoconstrictor action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Phenylephrine hydrochloride , being an agonist of alpha1-adrenergic receptors, causes vasoconstrictor effect . Due to vasoconstriction, it decreases mucous membrane , is eliminated hyperemia , drainage increases paranasal sinuses nose and the secretion of the mucous membrane is normalized.

Pharmacokinetics

When applied topically, penetration of the drug into (systemic absorption) is negligible. The effect of the drug is observed within 3-6 minutes after use. The duration of the vasoconstrictor effect is 6 hours. Symptoms disappear 3-5 days after the start of treatment.

Indications for use

Nazol nasal drops are used for symptomatic treatment of:

• acute rhinitis for colds;
• caused by plant pollen, accompanied by acute rhinitis.

Contraindications

• Increased sensitivity to the drug;
• Diseases thyroid gland And ;
• Heart , And increased .

Side effects

Local reaction appears burning, tingling And tingling in the nose .

Systemic reactions: flushing of the face, hands, palpitations, pale skin, causeless fear And sleep disturbance .

Side effects are possible with long-term use and when recommended doses are exceeded.

Nazol Baby, instructions for use (Method and dosage)

Drops are applied intranasally . During instillation, the head should be thrown back. Holding the bottle upside down, press it several times depending on required quantity drops To avoid side effects The instructions for Nazol Baby must be strictly followed.

Children from 2 months to 1 year - 1 drop no more than 4 times a day and no more often than every 6 hours.

Children over 6 years of age are prescribed 3-4 drops.

For the treatment of rhinitis in children starting from 6 years of age, the drug Nazol Kids is offered.

Treatment is carried out for no more than 3 days.

Overdose

If the recommendations are followed, the use of Nazol Baby is not accompanied by an overdose. When using high doses possible heaviness in the head, ventricular extrasystole, short-term attacks ventricular tachycardia, increased blood pressure And excessive excitability . In case of overdose, you must stop treatment with the drug and consult a doctor.

Interaction

The drug is not recommended for use simultaneously with other vasoconstrictors. The drug is not recommended to be prescribed simultaneously with monoamine oxidase inhibitors (procarbazine, selegin), guanedrel And guanethidine , which enhance the vasoconstrictor effect of phenylephrine.

The most popular drugs in the treatment of runny nose are vasoconstrictors, which are introduced into nasal cavity. A representative of this group of drugs is Nazol Baby. In what cases is it prescribed to children, at what age and in what dose is it used?

Release form

Nazol Baby is available in the form of nasal drops. Medicine presented clear liquid without smell. This liquid is usually colorless, but can also be light yellow. The solution is sold in polyethylene bottles with a spout, the capacity of which is 5, 10 and 15 ml, as well as 30 ml.

Compound

The compound that provides Nazol Baby drops healing effect, is phenylephrine hydrochloride. The concentration of this substance in the drug is 0.125%, that is, 100 ml of drops contains 0.125 g of phenylephrine. Auxiliary components Macrogol 1500, purified water, glycerol, potassium dihydrogen phosphate and benzalkonium chloride are used. The drug also includes disodium edetate and sodium hydrogen phosphate, presented in the form of dihydrate.

A drug similar in composition is Nazol Kids. The only difference is the release form (it is produced in the form of a nasal spray) and the concentration of phenylephrine (100 ml of the drug contains 0.25 g of such an active ingredient, so the concentration of the solution is 0.25%), as well as the addition of eucalyptol to the composition.

Nazol Baby and Nazol should not be confused, because active ingredient The second drug is another substance - oxymetazoline. In addition, Nazol is produced only in the form of a spray, so it is used from the age of 6. Oxymetazoline is the main ingredient in the drug Nazol Advance. It is also available as a nasal spray and is used for ages 6 years and older.

Separately, we note the drug Nazol Aqua, which does not contain vasoconstrictors. The base of this nasal spray is sodium chloride at a concentration of 0.65%. It is completely safe for children, so it is used from birth.

Operating principle

Phenylephrine, present in Nazol Baby, is an alpha-adrenergic stimulating substance. It activates alpha-adrenergic receptors in the nasopharyngeal mucosa, as a result of which hyperemia and swelling of the tissues decrease and congestion disappears. The use of such a medicine helps improve the passage of air through the nasopharynx and alleviates inflammation of the nasal mucosa.

Indications

Nazol Baby drops are prescribed for difficult nasal breathing, which is noted with allergic rhinitis, acute viral sinusitis or rhinitis, flu, colds and other diseases.

In this video, Doctor Komarovsky will tell us everything about children's runny nose and the most popular medications for the common cold.

At what age is it allowed to take it?

The instructions for Nazol Baby drops specify that up to the age of six, this medication should be used only after consultation with a doctor. A pediatrician can prescribe such drops at any age, including children under one year old, if there are indications for this.

The drug Nazol Kids can be used from the age of 4, but in children 4-6 years old this spray is used with extreme caution.

Contraindications

Treatment with nasal drops Nazol Kids is prohibited when hypersensitivity to the components of the drug. Also, this medication is not prescribed:

• With thyrotoxicosis.
• For arterial hypertension.
• For pathologies of the cardiovascular system.
• For diabetes mellitus.
• When treated with MAO inhibitors (including the period 2 weeks after stopping such medications).

Side effects

In some children, the use of Nazol Baby drops leads to tingling, pinching or burning sensations in the nasopharynx. Very rarely children's body reacts to treatment with this remedy with headaches, tremors, pale skin, increased blood pressure, dizziness, irregular heartbeat, sweating, and sleep problems.

Instructions for use

The bottle needs to be turned upside down and pressed slightly so that the drops get into the nasal passages little patient. As soon as the child’s nose is dripped, the bottle pipette must be wiped dry and then the cap must be screwed on tightly.

The pediatrician determines the dosage of Nazol Baby by age. For babies in the first year of life (for example, for a 3-month-old baby), a single dose will be only one drop in each nostril. For children over a year old up to 6 years of age, you can instill 1-2 drops, and for a child six years old or older - 3-4 drops at once.

Nazol Baby drops should be administered into the nose at intervals of at least 6 hours. The duration of treatment with this medication should not exceed three days.

Overdose

If you use Nazol Baby in too high a dose, it will lead to the appearance of system effects such as headache, nervous excitement, heaviness in the limbs and head, arrhythmic contraction of the heart, hypertension, increased sweating and dizziness. To eliminate such symptoms, alpha or beta blockers are prescribed.

Interaction with other drugs

Nazol Baby is not used simultaneously with thyroid hormones, tricyclic antidepressants, MAO inhibitors and some other drugs, as this increases the risk side effects on the heart and blood vessels. In addition, treatment with Nazol Baby drops and other nasal agents with a vasoconstrictor effect should not be combined.

Terms of sale

You can buy Nazol Baby at a pharmacy without having to present a prescription from a doctor. average price a bottle of drops with a capacity of 10 ml is 170-190 rubles.

Storage conditions and shelf life

Nazol Baby should be kept at home away from sunlight, and the storage temperature should not exceed the limit from +15 to +30 degrees Celsius. It is very important that such a drug cannot be accidentally taken out and drunk Small child. The shelf life of the drops is 2 years from the date of production.

If children have a cold and their nose can’t breathe, it will cope with the problem perfectly. medicinal product Nazol. The main effect of the medicine is its ability to constrict blood vessels and relieve swelling. The drug is quite safe and effective for children, has minor side effects, which can be avoided by strictly following the instructions.

When choosing a medicine for children for nasal congestion, you must first find out about the quality of the product, contraindications and possible side effects. Nazol should be used if the baby’s nose stops breathing and you notice that the child is breathing through his mouth. The reason for this may be colds in children, such as acute respiratory viral infections, influenza, or nasal swelling caused by allergies.

Drops or spray

There are several forms of release this drug, child-friendly. Firstly, the form that is already classic for many is Nazol drops, its other name Nazol Advance. Thanks to the properties of the substances that make up the medicine, it can be quickly, effectively, and most importantly, carefully removed. Such drops act for quite a long time and the effect of one application can last half a day. But use Nazol Advance infants it is not possible, since it contains substances that irritate the baby’s nasal mucosa and cannot ensure complete safety for the baby’s health.

The following release form is Nazol spray. Already in the name it is clear how this drug differs from the previous one - convenient form release with a spray nozzle provides excellent drug delivery and ease of use. The advantage of the spray attachment is that using the drug, the risk of overdose is significantly reduced. One injection - one dose.

Another type of drug - Nazol Kids. This drug is designed specifically for children. The composition includes the substance phenylephrine, which is the safest when applied to children; it acts gently, without irritating the child’s mucous membranes. The nozzle is also in the form of a spray, the effectiveness of which was mentioned above.

And the last form from the list is Nazol Baby. This, just like Nazol Kids, contains substances that are as safe as possible for children. Nazol Baby contains eucalyptus extract to keep baby's nose moisturized. Distinctive feature Nazol Baby is equipped with a convenient pipette. Nazol Baby can be given to children up to one year old and the pipette makes it very easy to administer the medicine into the nose.

How to use

Nazol is a medicine for intranasal administration, where active substance which is phenylephrine. When we use drops, phenylephrine helps to constrict the vessels of the nasal cavity, which makes breathing easier and removes swelling of the nasal mucosa. And eucalyptus extract moisturizes and softens inner surface nose The drug is used for diseases such as rhinitis, sinusitis, etc.

Dosage

The dosage is selected according to the chosen release form. Nazol Baby is suitable for children from birth. As for other types of the drug, there are age restrictions. So, if these are Nazol Advance drops or Nazol Spray, then, as the instructions show, the drug should be used by children at least six years old. We administer 2-3 drops into each nostril for a sick child a maximum of 2 times a day, and for children from six to twelve years old – one drop.

According to the instructions, Nazol Kids can be used by children from four to twelve years old. For children aged four to six years, we give two injections into each nostril. According to the instructions, the procedure can be repeated after 6 hours. Children from six to twelve years old can receive up to three injections. The procedure can be repeated after 4 hours. It is worth remembering that you can treat yourself for a maximum of five days and if the situation does not change for the better, you need the help of a doctor.

Using Nazol Baby, children from birth to one year usually receive one drop in each nostril. Children from two to six years old need to drip 2-3 drops. Here the instructions say that you can use Nazol Baby a maximum of 4 times per day. It is important to wait at least 6 hours between uses. If the effect is not visible within three days and the child still has a stuffy nose, you should consult a doctor and stop self-treatment.

It is not recommended to use one bottle of medicine when treating several family members at once, as this may contribute to the infection of healthy children.

Contraindications and side effects

Nazol has few side effects and contraindications for children, but they still exist. Very rarely, a burning sensation and tingling sensation inside the nose, redness of the face, rapid heartbeat, dizziness and a feeling of internal discomfort, or rather fear, may appear. As noted in the instructions, this can only happen if Nazol is used beyond the prescribed period or if it is administered at large quantities, violating the dosage. Contraindications for the medicine, according to the instructions, are individual intolerance children of the components included in the medicine. Nazol is also contraindicated in children with thyroid diseases, diabetes mellitus, children with arrhythmia and high blood pressure.

Price and analogues

Compared to other drugs in this group, the price of Nazol is quite reasonable and amounts to approximately 150-170 rubles, depending on the region and pharmacy chain. TO similar drugs One can safely include such nasal remedies as, which is purified sea water. The safety of this medicine is definitely higher; if Nazol is contraindicated for your child, then Aqua Maris is perfect, but in terms of effectiveness it is inferior to drugs with vasoconstrictor properties. The price of Aqua Marisa is about 250 rubles.

Another drug based sea ​​water– Aqualor Baby. Suitable for children from birth, cleanses and relieves nasal inflammation, can be used every day as a preventive measure. Its price is 320 rubles

– the drug in separate dropper bottles is a saline solution. Otrivin Baby helps cleanse the nose and moisturize it, acts gently and effectively, and helps improve immunity. Can also be used from birth. The price of Otrivin Baby is 168 rubles.

- a drug that contains two active components. One helps in relieving nasal swelling, while the other helps reduce itching and sneezing. Vibrocil acts gently and effectively, and the safe substances included in its composition allow you to use the drug for up to 7 days. This drug relieves swelling of the nasal cavity and makes breathing easier. Its price is 245 rubles.