Purified staphylococcal toxoid is a staphylococcal toxin neutralized by formaldehyde and heat, purified from ballast proteins.

1.0 ml of the drug contains from 10 to 14 EU (binding units) of staphylococcal toxoid.

The drug does not contain preservatives or antibiotics.

Transparent liquid, colorless or light yellow.

Contraindications for the use of purified staphylococcal toxoid are: acute infectious and non-infectious diseases of non-staphylococcal etiology, chronic diseases of non-staphylococcal etiology in the acute stage or decompensation - vaccinations are carried out no earlier than 1 month after recovery (remission).

Use with caution if you have a history of severe allergic reactions(anaphylactic shock, Quincke's edema); during pregnancy (since there is insufficient data on the safety of the drug in pregnant women).

Staphylococcal toxoid, purified, is injected subcutaneously under the lower corner of the scapula, alternating the right and left sides with each subsequent injection. Intramuscular use the drug is not allowed.

The drug contained in ampoules with damaged integrity, labeling, or changes is not suitable for use. physical properties(presence of turbidity, flakes), expired, in violation of storage conditions. Opening the ampoules and administering the drug to patients is carried out in strict compliance with the rules of asepsis and antisepsis.

The drug cannot be stored in an opened ampoule.

Full course treatment includes 7 injections of the drug, carried out with an interval of 2 days, in the following increasing doses: 0.1-0.3-0.5-0.7-0.9-1.2-1.5 ml.

With a rapid clinical effect, the course of therapy at the discretion of the attending physician can be reduced to 5 injections.

Administration of the drug may be accompanied by general, local and focal reactions.

General reactions characterized by mild weakness, malaise, and occasionally an increase in temperature up to 37.5 °C.

For local reactions Characterized by hyperemia and mild pain at the injection site, disappearing after 1-2 days.

Often, after injection of the drug, a focal reaction may occur, i.e. exacerbation of the process at the place of its localization.

The occurrence of these reactions is not a contraindication for continued treatment. However, if there are both general and local reactions, the interval between the previous and subsequent injections of the drug is recommended to be increased by 1 day. The development of a focal reaction does not require an increase in the interval between injections.

Treatment with purified staphylococcal toxoid can be carried out simultaneously with other general and local therapy, with the exception of immunoglobulins and antistaphylococcal plasma.

Transportation. In accordance with SP 3.3.2.1248-03 at temperatures from 2 to 8 °C. Freezing is not allowed.

"Staphylococcal toxoid" is used to stimulate immune system to further production of antibodies against pathogenic microorganisms, including staphylococci.

Indications for use

The drug is used to prevent infections caused by staphylococci in patients with high risk development of the disease.

“Staphylococcal toxoid” is also used to maintain the immunity of donors when receiving anti-staphylococcal immunoglobulin and plasma.

Using this drug, it is possible to carry out specific immunotherapy during the treatment of staphylococcal infections in acute and chronic forms.

Compound

Main active ingredient The drug is staphylococcal toxoid. There are no antibacterial components or preservatives in the composition.

Medicinal properties

Anatoxins are immunobiological agents used to activate immunity against staphylococci in vaccinated people. Toxoid-based vaccines are used to prevent a number of diseases.

The production of toxoid is carried out during the specific processing of exotoxins of pathogenic microorganisms. This results in a highly effective drug wide range actions. The vaccine does not have a pronounced effect toxic effect on the body, helps in inducing antibodies to pathogens.

Often, toxoids are presented in a purified solution - a concentrate; “Staphylococcal toxoid” can also be classified as one of them. Vaccination using this drug recommended for the prevention of various diseases infectious nature, and for the treatment of immunodeficiency conditions.

The drug is effective not only in the fight against staphylococcus pathogens, active substance It also has a detrimental effect on other types of bacteria (unrelated antigens). Therefore, vaccination with Anatoxin is also possible for diseases caused by pathogenic microorganisms of various kinds.

The average price is from 500 to 1200 rubles.

Release form

The drug "Staphylococcal anatoxin" is a solution of homogeneous white shade without flakes and turbidity, available in ampoules.

Mode of application

The vaccine is injected under the skin in the area of ​​the lower angle of the scapula. During subsequent injections, you should alternate its administration into the right and left shoulder blade. The initial dosage of the drug is 0.1 ml. Subsequent injections are carried out by administering a dose of 0.2 ml. Once the volume of administered medication reaches 0.9 ml, the next dosage will be 1.2 ml, then 1.5 ml.

Therapy is designed for 7 subcutaneous injections, held at intervals of two days. When observing high therapeutic effectiveness vaccination can take place with only 5 injections.

During pregnancy and breastfeeding

During pregnancy, vaccination with the drug is contraindicated. The medicine cannot be used for prevention or treatment during lactation, since there is no data on the effect of the components on the baby’s body.

Contraindications

The instructions for the drug "Anatoxin" contain information about a number of diseases and symptoms for which injections are contraindicated:

• Chronic forms of diseases of non-infectious origin during exacerbation
• Serious allergic manifestations
• Pathologies of the kidneys and liver
• Brain stroke
• Pathological changes occurring in the pancreas
• Severe heart disease
• Bronchial asthma
• The first signs of myocardial infarction.

Precautionary measures

The process of opening ampoules with medicine, as well as its further administration, is carried out in accordance with existing rules antiseptics and aseptics.

Cross-drug interactions

The use of the drug is possible in combination with a general or local treatment regimen. The combination of the drug with immunoglobulin drugs, as well as anti-staphylococcal plasma, is not recommended.

Side effects

Vaccination for preventive purposes, as well as treatment with the use of the drug "Anatoxin" may be accompanied by adverse reactions, which are observed in the form allergic manifestations. Along with this, it is possible slight increase body temperature, general malaise and weakness, exacerbation of an existing infectious disease cannot be ruled out.

The presence of the symptoms listed above is not the main reason for stopping treatment. It is often possible to get rid of an adverse reaction by increasing the time interval between injections.

Conditions and shelf life

Ampoules with solution must be stored at a temperature of 2 to 8 degrees for 2 years from the date of production. The Staphylococcal Anatoxin solution must not be frozen.

If the integrity of the bottle, its labeling is damaged, in case of changes appearance solution (formation of flakes, cloudiness), if the expiration date has expired or the storage conditions have not been met, the drug cannot be used in the future.

An opened ampoule of the drug "Anatoxin" cannot be stored.

Analogues

Microgen, Russia
Price from 735 to 945 rub.

"Staphylococcal bacteriophage" is indicated for use when various diseases caused by staphylococcal pathogens, can be used for prevention purposes purulent processes on damaged skin. The drug is available in the form liquid solution in bottles, aerosols, suppositories.

pros

• Can be purchased at almost any pharmacy
• No contraindications for use
• Ease of use thanks to various forms release

Minuses

• When administered subcutaneously, slight redness of the skin may occur.
• There is no data on use during pregnancy or lactation.

PHARMSTANDARD-TOMSKKHIMFARM, Russia
Price from 440 to 969 rub.

Spray for local application"IRS-19" contains a mixture of lysates that have an immunostimulating effect. Used for the prevention and treatment of diseases of the upper respiratory tract viral and bacterial nature.

pros

• Acceptable price
• Promotes recovery local immunity after operations on ENT organs
• Can be used to treat children from 3 months

Minuses

• Not recommended for use in autoimmune disorders
• Adverse reactions from the gastrointestinal tract and allergic manifestations are possible.

The long course of infectious pathologies is usually caused by the presence of staphylococcus in the body. This pathogen is contagious and dangerous; it can cause furunculosis, inflammation of the genital organs, mastitis, otitis media, sore throat, meningitis, and pneumonia. Infection of any location can lead to blood poisoning and death.

Diseases caused by Staphylococcus aureus. Taking antibiotics in this case does not help. Staphylococcal toxoid is used to treat and prevent pathologies.

Composition and release form

The manufacturer of the product is a branch of the Research Institute named after. N.F. Gamaleya "Medgamal", located on the territory of Russia.

The medication is available in the form of a clear, colorless liquid (a light yellow tint is allowed).

A milliliter of solution contains the following components:

• staphylococcal toxoid – 10-14 binding units;
• aluminum – 1.3 mg;
• merthiolate – 80 mcg.

There are no preservatives or antibacterial substances in Staphylococcal toxoid. The drug is packaged in ampoules. Each container contains 1 ml of solution, designed for several doses.

pharmachologic effect

Anatoxin is intended to produce defensive reaction the body in response to the penetration of staphylococci. After the drug is introduced into the blood, specific antibodies begin to be produced. As a result, the likelihood of developing pathology is reduced, pathogenic microorganisms they die immediately. Doctors also note the drug’s activity against unrelated antigens. Therefore, the medication is sometimes used in the treatment of diseases caused by other pathogens.

Toxoid suspension

After an injection course of anti-staphylococcal drug, a person becomes protected for at least a year. The immunomodulatory and immunocorrective activity of the drug has been proven laboratory and clinically.

Indications and contraindications for use

Staphylococcal toxoid is prescribed by doctors for the purpose of immunoprophylaxis and treatment acute infections or chronic pathologies. The drug is used for adults. Need in this medicine determined by a specialist based on the results of immunological and microbiological studies.

The product has a number of contraindications:

• bronchial asthma;
• pregnancy at any stage;
• cerebral stroke;
• asthmatic type bronchitis;
• exacerbation of pathologies of non-infectious nature;
• angina pectoris;
• myocardial infarction;
• problems with the pancreas;
• severe liver failure;
• third stage hypertension;
• nervous system disorder;
• vitamin D deficiency of the second degree;
• active stage tuberculosis;
• anorexia;
• Quincke's edema;
• circulatory diseases;
• childhood;
• dysfunction of the endocrine system;
• malnutrition;
• presence in anamnesis anaphylactic shock and other manifestations of severe allergies.

Staphylococcal purified adsorbed Anatoxin: instructions for use

Therapy with staphylococcal adsorbed purified toxoid is carried out according to a specific scheme. Medicine is administered subcutaneously to the area of ​​the lower angle of the scapula. For repeated injections, it is recommended to alternate between the right and left sides. The product cannot be injected into the muscle.

It is prohibited to use toxoid:

• expired;
• with damaged integrity of the ampoule;
• at wrong conditions storage

The ampoule must be opened immediately before manipulation, strictly observing the rules of antisepsis and asepsis.

• The course of treatment includes seven injections, which are given at two-day intervals.
• first injection – 0.1 ml;
• second – 0.3 ml;
• third – 0.5 ml;
• fourth – 0.7 ml;
• fifth – 0.9 ml;
• sixth – 1.2 ml;

seventh – 1.5 ml.

Possible side effects and complications Vaccination creates reliable protection from diseases. But at the same time, it can provoke adverse reactions and complications. Usually negative symptoms

arise during the use of the drug in the presence of contraindications, violation of asepsis rules. Most common common:

• side effects
• increase in temperature to subfebrile condition;
• lethargy;
• malaise;
• headache;

apathy.

Negative symptoms of vaccination can also appear locally. In this case, the patient complains of compaction, mild pain, and swelling in the injection area. Such phenomena usually resolve within two days and do not require medical intervention.

If, simultaneously after vaccination, a person experiences local and general adverse reactions, then the doctor can increase the interval between vaccinations to three days. Such patients require monitoring by medical staff, as they have an increased risk of developing severe allergic conditions. IN in rare cases

• Staphylococcal toxoid leads to the following complications:
• fever (temperature rises to 38-40 degrees);
• unbearable pain at the injection site;

the formation of accumulations of blood and lymph under the skin with a diameter of more than two centimeters. To avoid negative results from vaccination, the patient must undergo thorough examination

and consult a doctor.

The cost of Staphylococcal toxoid starts from 1250 rubles per package of 10 ampoules of one milliliter. The drug is supplied exclusively to outpatient and outpatient medical institutions stationary types : purchase the product yourself in pharmacy outlets

Staphylococcal toxoid should be stored in the refrigerator at temperatures from +2 to +8 degrees Celsius for two years from the date of production.

It is prohibited to hold the product at sub-zero temperatures. If accidentally frozen, the drug becomes ineffective and must be disposed of. It is also important to keep the medicine away from direct sunlight.

Analogues of liquid staphylococcal polyvalent vaccine

Staphylococcal liquid polyvalent vaccine has analogs in the form Staphylococcal bacteriophage and IRS-19. The drugs differ in cost, features of use and list of possible adverse reactions.

Bacteriophage

Used when various pathologies caused by staphylococcus, as well as to prevent purulent processes on the skin. Available in the form of a solution and packaged in a bottle. The cost varies from 730 to 950 rubles. The advantages of bacteriophage are availability, lack of contraindications, and ease of use. The product can cause slight redness of the epidermis at the injection site.

Bacteriophage

This is a mixture of lysates that stimulate protective forces body to fight infectious pathologies. Used for the treatment and prevention of upper respiratory tract diseases bacterial origin. The medicine costs about 440-970 rubles. Its advantages include an affordable price and the development of local immunity after surgical intervention on ENT organs.

Immunomodulatory drug Pharmstandard IRS

The disadvantages of the medicine are a wide list of contraindications: it is prohibited to use it for allergies, autoimmune disorders, and disorders of the gastrointestinal tract.

Also, to protect and treat pathologies caused by staphylococcus, the following toxoid analogues are used in Russia:

• VP-4 vaccine;
• antistaphylococcal immune human plasma;
• homologous liquid antistaphylococcal immunoglobulin.

Antistreptococcal serum, toxoid or antifagin: which is better?

The serum is intended for the treatment of pathologies caused by staphylococcus. Antifagin allows you to develop immunity against pathogens for a year infectious diseases. Anatoxin is used for treatment and prevention. Which drug is better, antistreptococcal serum, antifagin or toxoid, depends on the situations and purposes of use. Doctors prefer antifagin, which protects against all existing types staphylococcus.

Enter the medicine into the search

Click the find button

Get an answer instantly!

Staphylococcal anatoxin instructions for use, analogues, contraindications, composition and prices in pharmacies

Latin name: Anatoxinum staphylococcus

Active substance: Staphylococcal anatoxin (Anatoxinum staphylococcus)

ATX code: J07AX

Manufacturer: Medgamal, NIIEM im. N.F. Gamaleyi RAMS (Russia)

Shelf life of the drug staphylococcal toxoid: 2 years

Storage conditions of the drug: This product must be kept in a dry, dark place out of reach of children. Storage temperature – 2-8°C. Ampoules should not be frozen.

Conditions for dispensing from pharmacies: Supplied only to medical institutions. You cannot buy it at a pharmacy.

Composition, release form, Pharmacological action staphylococcal toxoid

Composition of the drug: staphylococcal toxoid

The composition of the drug includes staphylococcal toxoid . The medicine does not contain preservatives or antibiotics .

Release form of the drug Staphylococcal toxoid

The drug is available in ampoules. The solution is whitish in color.

Pharmacological action of the drug staphylococcal toxoid

This drug serves to induce an immune response in the body aimed at pathogens and their toxins.

Indications for use of the drug staphylococcal toxoid

Indications for use of the drug staphylococcal toxoid are:

This drug is indicated for specific immunotherapy of acute or chronic staphylococcal infection in adult patients.

Contraindications for use staphylococcal toxoid

Contraindications to the use of the drug staphylococcal toxoid are:

The use of the drug is contraindicated in:

• exacerbation of chronic diseases of non-infectious origin;
• the presence of severe allergic reactions;
• cerebral stroke;
• severe liver and kidney diseases;
• complicated liver failure;
• diseases of the pancreas and cardiovascular system;
• bronchial asthma;
• angina pectoris;
• hypertension (stage III);
• pregnancy;
• early stage of myocardial infarction.

staphylococcal toxoid— Instructions for use

The instructions for Staphylococcal Anatoxin indicate that the drug is injected subcutaneously into the lower corner of the scapula. With each injection, the right and left sides alternate.

This product should not be used if the integrity of the ampoule has been damaged or it has been stored incorrectly. It is necessary to open ampoules with medicine and administer it, strictly observing the rules of asepsis.

The course consists of seven injections. They are done after 2 days, gradually increasing the dosage. At the beginning, 0.1 ml of the drug is administered. Each time the dose is increased by 0.2 ml. Once the dosage of 0.9 ml is reached, the next dose is 1.2 ml, then 1.5 ml.

In case of rapid clinical effect, the course can be reduced to 5 injections.