Ubistezin release form. The drug 'Ubistezin' - instructions for use, description and reviews
If long-term surgical intervention on the face is required, a sensitivity reaction is observed to many local anesthetics, with an unstable mentality of the patient, general anesthesia or sedation (drug sleep) is used.
It is also possible to lubricate tissues with an anesthetic. This method is well suited for the treatment of small patients or when removing dental deposits. The drug is applied with a cotton swab. Very rarely, anesthesia is used by electrophoresis or inkjet method, using an injector, an electromagnet and a laser, freezing.
Local complications of local anesthesia in dentistry are short-lived. So, when using disposable needles, they are very rare, but they can break. To prevent this from happening, the needle is not inserted to its full length.
To ensure that the patient does not feel pain during the injection, the anesthetic is injected very slowly. There are also nerve injuries that slightly reduce sensitivity for a month. The frequency of this complication is about 20%. Sometimes a spasm of the chewing muscles can occur. It is associated with needle injury to blood vessels. Tissue necrosis may also develop.
The advantages of local anesthesia in dentistry over anesthesia are obvious: in most cases, local anesthesia is easily tolerated, and the toxicity of local anesthetics is minimal.
However, there are times when general anesthesia is justified. It can be mask anesthesia, endotracheal or intravenous. For general anesthesia, the dental clinic must have a special permit. Most often, general anesthesia is used for dental implants. Before general anesthesia, the patient undergoes an examination, as before an operation, doctors study his anamnesis in detail. Under general anesthesia, you can treat many diseased teeth at once and save time. General anesthesia is contraindicated in case of heart disease, stroke, asthma, diabetes mellitus, liver and kidney diseases with a significant decrease in their function, pregnancy.
Care should be taken with anesthesia in patients with diabetes mellitus and a recent myocardial infarction.
Pain relief reinforces the normal response to dental treatment. Dentistry and pain today are incompatible concepts. Therefore, fewer people are afraid of dental treatment. You can always choose an anesthetic that is right for you. No longer uses toxic novocaine. The patient does not experience stress and negative emotions when visiting the dentist, and the doctor calmly performs all the manipulations. The success of treatment is determined not only by the extent to which new tools and technologies are used, not only by the skills of the doctor, but also by the psychological mood of the patient. And it cannot be positive if the patient is afraid. This factor is especially important in dental surgical interventions, since a person who is even slightly sensitive to pain and calmly tolerates dental treatment without anesthesia will not want to remove teeth without anesthesia. Especially when it is necessary to install implants by implanting them into the bone. Most clinics use high-quality and safe imported drugs for pain relief. They can be used by pregnant women, they do not contain adrenaline. Sedatives may also be used to calm the mind. This is called premedication.
Registration number:
Brand name of the drug: UBISTESIN
Dosage form:
Solution for injection (with epinephrine)
Compound
1 ml contains:
active substances: articaine hydrochloride 40 mg, epinephrine hydrochloride 0,006 mg (equivalent to 0.005 mg epinephrine)
Excipients: water for injection, sodium sulfite (equivalent to 0 31 mg SO2), sodium chloride.
Description
Clear, colorless liquid.
Pharmacotherapeutic group
Local anesthetic + vasoconstrictor
ATX code: N018858
pharmachologic effect
Ubistezin is a combined drug for local anesthesia in dentistry. Articaine, which is part of it, is a local anesthetic of the amide type of the thiafene group. The action of the drug begins quickly - after 1-3 minutes. The duration of anesthesia is at least 45 minutes. Wound healing proceeds without complications due to good tissue tolerance and minimal vasoconstrictive effect. Due to the low content of epinephrine in the preparation, its effect on the cardiovascular system is little expressed: there is almost no increase in blood pressure and an increase in heart rate.
Pharmacokinetics. Articaine with submucosal administration in the oral cavity has a high diffuse ability. Communication with proteins is 95%. Active substances penetrate the placental barrier to a minimal extent, are practically not excreted in breast milk, the half-life is 25 minutes.
Indications for use
Infiltration and conduction anesthesia in dentistry (especially in patients with concomitant severe somatic diseases), including during the following manipulations:
It is possible to use the drug during pregnancy. If it is necessary to use the drug in a nursing mother, there is no need to interrupt feeding, since the active substances are not excreted in breast milk in clinically significant amounts. Dosage and administration
With uncomplicated extraction of the teeth of the upper jaw in the absence of inflammation, 1.7 ml of the drug is usually injected into the submucosa in the region of the transitional fold from the vestibular side (for each tooth). In some cases, an additional injection of 1 to 1.7 ml of the drug may be required to achieve complete anesthesia. In most cases, it is not necessary to perform painful injections from the palatal side. For anesthesia with palatine incisions and suturing in order to create a palatine depot, about 0.1 ml of the drug is needed per injection. When removing several adjacent teeth, the number of injections can usually be limited. In the case of removal of the mandibular premolars in the absence of inflammation, mandibular anesthesia can be dispensed with, because. infiltration anesthesia provided by an injection of 1.7 ml per tooth is usually sufficient. If this way it was not possible to achieve the desired effect, an additional injection of 1-1.7 ml of the drug should be performed into the submucosa in the region of the transitional fold of the lower jaw from the vestibular side. If, in this case, it was not possible to achieve complete anesthesia, it is necessary to block the mandibular nerve.
To prepare the cavity of the tooth for filling or processing under the crown of any tooth, with the exception of the lower molars, the administration of the drug at a dose of 0.5 to 1.7 ml per each tooth is indicated according to the type of infiltration anesthesia from the vestibular side. The exact amount depends on the desired depth and duration of the procedure. When performing one medical procedure, adults can enter up to 7 mg of articaine per 1 kg of body weight. The duration of anesthesia during which the intervention can be performed is 30-45 minutes. Side effect
The drug is usually well tolerated by patients, but the following side effects may develop:
From the side of the central nervous system(depending on the size of the applied dose): headache, impaired consciousness up to its loss, respiratory failure up to its stop, muscle tremor, involuntary muscle twitching, sometimes progressing to generalized convulsions;
From the side of the digestive system: nausea, vomiting, diarrhea;
From the side of the organ of vision: rarely - "clouding" in the eyes, transient blindness.
From the side of the cardiovascular system: moderate hemodynamic disturbances, manifested in a decrease in blood pressure, tachycardia or bradycardia, depression of cardiovascular activity, which in extreme manifestation can lead to collapse and cardiac arrest, which threatens the patient's life.
Allergic reactions: swelling or inflammation at the injection site; in other areas - skin redness, itching, conjunctivitis, rhinitis, angioedema of varying severity (including swelling of the upper and / or lower lip and / or cheeks, glottis with difficulty swallowing, urticaria, difficulty breathing). All these phenomena can progress to the development of anaphylactic shock.
Local reactions: swelling or inflammation at the injection site; the appearance of ischemic zones at the injection site (up to the development of tissue necrosis - with accidental intravascular injection);
Others: headaches are often observed, probably associated with the presence of epinephrine in the preparation; other side effects caused by the action of epinephrine (tachycardia, arrhythmia, increased blood pressure) are extremely rare; nerve damage (up to the development of paralysis) - occurs only if the injection technique is violated. Overdose
Symptoms: dizziness, restlessness, impaired consciousness, lowering blood pressure, tachycardia, bradycardia.
Treatment: when the first signs of an overdose appear during the injection, it is necessary to stop the administration of the drug, give the patient a horizontal position, ensure free airway patency, control heart rate and blood pressure. In case of respiratory failure - oxygen, endotracheal intubation, artificial ventilation of the lungs (central analeptics are contraindicated); with convulsions - intravenously slowly short-acting barbiturates with simultaneous oxygen supply and hemodynamic control; with severe circulatory disorders and shock - intravenous infusion of electrolyte solutions and plasma substitutes, glucocorticosteroids, albumin; with vascular collapse and increasing bradycardia - intravenously slowly epinephrine 0.1 mg, then intravenously drip under the control of heart rate and blood pressure; with severe tachycardia and tachyarrhythmia - intravenous beta-blockers (selective); with an increase in blood pressure - peripheral vasodilators. Oxygen therapy and monitoring of blood circulation parameters are necessary in all cases. Interaction with other drugs
The hypertensive effect of sympathomimetic amines such as epinephrine can be enhanced by tricyclic antidepressants and monoamine oxidase inhibitors.
An interaction of this type has been described for epinephrine and norepinephrine when used as vasoconstrictors at concentrations of 1:25,000 and 1:80,000, respectively.
The drug should not be prescribed during treatment with non-selective beta-blockers, since in this case there is a high risk of developing a hypertensive crisis and severe bradycardia.
The local anesthetic effect of articaine is enhanced and lengthened by vasoconstrictor drugs. special instructions
Ubistezin contains sulfites, which may increase the anaphylactic reaction.
The drug should not be administered intravenously. Do not inject into the area of inflammation.
Eating is possible only after the restoration of sensitivity.
To prevent infection (including hepatitis), it is necessary to always use new sterile syringes and needles every time a solution is taken from vials or ampoules. Opened cartridges must not be used again for other patients (risk of hepatitis).
Do not use a damaged cartridge.
It does not have a harmful effect on the fetus (with the exception of possible bradycardia) with any application technique and dosage. Influence on the ability to drive vehicles and control mechanisms.
In special tests, there was no clear effect of the drug on the concentration of attention and the speed of motor reactions. However, due to the fact that the patient's preoperative anxiety and stress caused by surgery can affect the effectiveness of the activity, the dentist must individually, in each case, decide on the admission of the patient to driving transport or working with mechanisms. Release form
Solution for injection with epinephrine in cartridges of 1.7 ml; 50 cartridges with instructions for use in a metal container with a metal and plastic lid. Storage conditions
List B.
At a temperature not exceeding 25 ° C, in a place protected from light and out of the reach of children. Best before date
2 years. Do not use after the expiry date stated on the package. Terms of dispensing from pharmacies
On prescription Manufacturer and address
3M ESPE AG, Seefeld, Germany
Compound
1 ml contains:
active substances: articaine hydrochloride 40 mg, epinephrine hydrochloride 0,006 mg (equivalent to 0.005 mg epinephrine)
Excipients: water for injection, sodium sulfite (equivalent to 0 31 mg SO2), sodium chloride.
Description
Clear, colorless liquid.
Pharmacotherapeutic group
Local anesthetic + vasoconstrictor
ATX code
pharmachologic effect
Ubistezin is a combined drug for local anesthesia in dentistry. Articaine, which is part of it, is a local anesthetic of the amide type of the thiafene group. The action of the drug begins quickly - after 1-3 minutes. The duration of anesthesia is at least 45 minutes. Wound healing proceeds without complications due to good tissue tolerance and minimal vasoconstrictive effect. Due to the low content of epinephrine in the preparation, its effect on the cardiovascular system is little expressed: there is almost no increase in blood pressure and an increase in heart rate.
Pharmacokinetics. Articaine with submucosal administration in the oral cavity has a high diffuse ability. Communication with proteins is 95%. Active substances penetrate the placental barrier to a minimal extent, are practically not excreted in breast milk, the half-life is 25 minutes.
Indications for use
Infiltration and conduction anesthesia in dentistry (especially in patients with concomitant severe somatic diseases), including during the following manipulations: uncomplicated extraction of one or more teeth; filling of carious cavities, grinding of teeth before preparation.
Contraindications
Hypersensitivity to articaine, epinephrine, sulfites, as well as to any of the auxiliary components of the drug; paroxysmal tachycardia and other tachyarrhythmias; bronchial asthma with increased sensitivity to sulfites; angle-closure glaucoma, simultaneous use of non-selective beta-blockers; severe form of liver failure (porphyria); hyperthyroidism; concomitant therapy with monoamine oxidase inhibitors or tricyclic antidepressants, cardiogenic shock. It is used with caution in the following cases: chronic heart failure, intraventricular and atrioventricular heart block, inflammation in the area of supposed anesthesia, cholinesterase deficiency, renal failure, diabetes mellitus, arterial hypertension, childhood, old age, severe general condition, debilitated patients. Use during pregnancy and lactation
It is possible to use the drug during pregnancy. If it is necessary to use the drug in a nursing mother, there is no need to interrupt feeding, since the active substances are not excreted in breast milk in clinically significant amounts. Method of application and dosage
With uncomplicated extraction of the teeth of the upper jaw in the absence of inflammation, 1.7 ml of the drug is usually injected into the submucosa in the region of the transitional fold from the vestibular side (for each tooth). In some cases, an additional injection of 1 to 1.7 ml of the drug may be required to achieve complete anesthesia. In most cases, it is not necessary to perform painful injections from the palatal side. For anesthesia with palatine incisions and suturing in order to create a palatine depot, about 0.1 ml of the drug is needed per injection. When removing several adjacent teeth, the number of injections can usually be limited. In the case of removal of the mandibular premolars in the absence of inflammation, mandibular anesthesia can be dispensed with, because. infiltration anesthesia provided by an injection of 1.7 ml per tooth is usually sufficient. If this way it was not possible to achieve the desired effect, an additional injection of 1-1.7 ml of the drug should be performed into the submucosa in the region of the transitional fold of the lower jaw from the vestibular side. If, in this case, it was not possible to achieve complete anesthesia, it is necessary to block the mandibular nerve.
To prepare the cavity of the tooth for filling or processing under the crown of any tooth, with the exception of the lower molars, the administration of the drug at a dose of 0.5 to 1.7 ml per each tooth is indicated according to the type of infiltration anesthesia from the vestibular side. The exact amount depends on the desired depth and duration of the procedure. When performing one medical procedure, adults can enter up to 7 mg of articaine per 1 kg of body weight. The duration of anesthesia during which the intervention can be performed is 30-45 minutes.
Side effect
The drug is usually well tolerated by patients, but the following side effects may develop:
From the side of the central nervous system(depending on the size of the applied dose): headache, impaired consciousness up to its loss, respiratory failure up to its stop, muscle tremor, involuntary muscle twitching, sometimes progressing to generalized convulsions;
From the side of the digestive system: nausea, vomiting, diarrhea;
From the side of the organ of vision: rarely - "clouding" in the eyes, transient blindness.
From the side of the cardiovascular system: moderate hemodynamic disturbances, manifested in a decrease in blood pressure, tachycardia or bradycardia, depression of cardiovascular activity, which in extreme manifestation can lead to collapse and cardiac arrest, which threatens the patient's life.
Allergic reactions: swelling or inflammation at the injection site; in other areas - skin redness, itching, conjunctivitis, rhinitis, angioedema of varying severity (including swelling of the upper and / or lower lip and / or cheeks, glottis with difficulty swallowing, urticaria, difficulty breathing). All these phenomena can progress to the development of anaphylactic shock.
Local reactions: swelling or inflammation at the injection site; the appearance of ischemic zones at the injection site (up to the development of tissue necrosis - with accidental intravascular injection);
Others: headaches are often observed, probably associated with the presence of epinephrine in the preparation; other side effects caused by the action of epinephrine (tachycardia, arrhythmia, increased blood pressure) are extremely rare; nerve damage (up to the development of paralysis) - occurs only if the injection technique is violated.
Overdose
Symptoms: dizziness, restlessness, impaired consciousness, lowering blood pressure, tachycardia, bradycardia.
Treatment: when the first signs of an overdose appear during the injection, it is necessary to stop the administration of the drug, give the patient a horizontal position, ensure free airway patency, control heart rate and blood pressure. In case of respiratory failure - oxygen, endotracheal intubation, artificial ventilation of the lungs (central analeptics are contraindicated); with convulsions - intravenously slowly short-acting barbiturates with simultaneous oxygen supply and hemodynamic control; with severe circulatory disorders and shock - intravenous infusion of electrolyte solutions and plasma substitutes, glucocorticosteroids, albumin; with vascular collapse and increasing bradycardia - intravenously slowly epinephrine 0.1 mg, then intravenously drip under the control of heart rate and blood pressure; with severe tachycardia and tachyarrhythmia - intravenous beta-blockers (selective); with an increase in blood pressure - peripheral vasodilators. Oxygen therapy and monitoring of blood circulation parameters are necessary in all cases. Interaction with other drugs
The hypertensive effect of sympathomimetic amines such as epinephrine can be enhanced by tricyclic antidepressants and monoamine oxidase inhibitors.
An interaction of this type has been described for epinephrine and norepinephrine when used as vasoconstrictors at concentrations of 1:25,000 and 1:80,000, respectively.
The drug should not be prescribed during treatment with non-selective beta-blockers, since in this case there is a high risk of developing a hypertensive crisis and severe bradycardia.
The local anesthetic effect of articaine is enhanced and lengthened by vasoconstrictor drugs.
Ubistezin (Ubistesin) refers to drugs that have a local anesthetic effect. The drug is one of the most modern and effective representatives of the group of local anesthetics.
Ease of use, a small amount of preservatives and adverse reactions allowed Ubistezin to become a choice in the presence of somatic pathologies in a patient. Dentists widely use anesthetic for and.
Anesthetic components and features of carpule
The preparation contains:
- articaine hydrochloride 40 mg;
- epinephrine hydrochloride or adrenaline;
- water for injections;
- sodium chloride;
- sodium sulfite.
The product is produced in 2 versions: Ubistezin 1/200000 and Forte version 1/100000. They differ in the amount of vasoconstrictor. In the first case, the amount of epinephrine will be 5 μg / ml, and in the second - 10 μg / ml.
The anesthetic itself is produced in the form of a 1.7 ml cartridge. They are packed in special cans with a soft surface on the inside.
Thanks to this, integrity is maintained during transportation, and further storage proceeds without any difficulties.
Moreover, each individual carpula has its own characteristics: 
- Coating of the inner surface with a special silicone layer. As a result, the injection becomes smooth and controlled, the piston moves more smoothly, and the amount of force applied is much less.
- All the necessary information is printed on the carpool with a marking tape. which replaced printing on glass. Accordingly, the risk of damage by fragments in the event of its destruction has decreased. This point is very important when conducting, since the pressure exerted in this case is very high.
Pharmacological properties
All properties of the drug are achieved due to the main active ingredients: articaine and epinephrine.
Articaine is a local anesthetic of the amide type. Its effect occurs within 2-3 minutes after administration and lasts approximately 50-60 minutes. Compared to older substances, such as novocaine or lidocaine, the effect of articaine is 2 times stronger.
It is also more quickly excreted from the body, does not increase the time of wound healing and has less toxicity. Therefore, Ubistezin can be used by the elderly, pregnant women and children over 5 years of age.
Epinephrine is responsible for blood vessels. It has a vasoconstrictive effect, which significantly increases the time of the anesthetic effect.
Thanks to this component, the drug has a high penetrating ability and almost completely binds to blood plasma proteins. This ensures the safety of its use in the treatment of pregnant and lactating women. The drug does not pass into breast milk and does not cross the placenta.
Scope of application and contraindications
The anesthetic is used for and during the following dental procedures:
Ubistezin, and even more so Ubistezin Forte, cannot be used for:
- individual intolerance to the components of the drug;
- paroxysmal ventricular tachycardia and atrial tachyarrhythmias;
- hyperthyroidism;
- angle-closure glaucoma;
- the use of non-selective beta-blockers;
- severe forms of liver failure;
- bronchial asthma;
- treatment with tricyclic antidepressants and drugs containing monoamine oxidase;
- cardiogenic shock;
- methemoglobinemia;
- B12 deficiency anemia.
Conditions in which the use of the product should be carried out with caution:
- cholinesterase deficiency;
- failure of the kidneys;
- diabetes;
- hypertonic disease;
- children under 4 years old.
How is the drug administered and in what dosages?
The method of administration and dosage of the anesthetic depends on the goals of the dentist:
The maximum dosage is calculated from the ratio of 7 mg of articaine per 1 kg of body weight. One cartridge contains 40 mg of anesthetic.
Application in special cases
Due to the low content of the vasoconstrictor, the risk of side effects is quite low. Therefore, the use of the drug in the treatment of patients with diseases of the cardiovascular system is not excluded.
During pregnancy, Ubistezin can be used, it does not have a harmful effect on the fetus. Only in rare cases does bradycardia develop. The drug of choice in such situations is a drug at a dosage of 1/200,000.
special instructions
Intravenous administration is completely excluded. To prevent the occurrence of such situations, an aspiration test should be carried out.
The drug can not be used in the area of a pronounced inflammatory process. It is recommended to inject the drug near the inflamed area.
To prevent the development of infections, needles and syringes must be changed during each collection from a vial or ampoule. Open carpules are not reused. It also excludes the use of damaged cartridges.
Possible adverse reactions and cases of overdose
Ubistezin can have the following inhibitory effect on body systems:
- Effect on the central nervous system. The patient may develop headache, loss of consciousness, respiratory failure, convulsions.
- Influence on the gastrointestinal tract. In some cases, nausea, vomiting and diarrhea occur.
- Changes in the functioning of the sense organs are rare. Sometimes, if the technique of anesthesia is violated, diplopia or a temporary impairment of visual acuity is possible.
- Effect on the heart and blood vessels. There is a possibility of lowering the level of blood pressure, tachy- or bradycardia, arrhythmia.
- allergic reactions. The skin may appear flushed and itchy. There is also a risk of developing allergic conjunctivitis and rhinitis. More serious complications include angioedema and anaphylactic shock.
- Local manifestations. Swelling or inflammation may occur at the injection site. If the anesthesia technique is violated, ischemia zones appear and the nerve trunk is damaged.
Symptoms of overdose of the drug are: 
- dizziness;
- change of consciousness;
- lowering blood pressure;
- tachy or bradycardia.
What to do if unwanted reactions occur:
- immediate stop of drug administration;
- giving the patient a horizontal position;
- providing oxygen;
- monitoring of pulse and pressure;
- in case of respiratory failure, the introduction of air ducts and artificial ventilation of the lungs is recommended;
- if convulsions appear, then barbiturates are used;
- circulatory disorders are corrected with electrolyte solutions;
- bradycardia is treated with intravenous administration of 0.1 mg of adrenaline;
- with tachycardia, selective beta-blockers are used;
- pressure is reduced by peripheral vasodilators.
Cost and analogues
The price of the Ubistezin Forte solution is 1500-2000 rubles for 50 cartridges, the drug at a dosage of 1/200000 - 1800-2200 rubles per pack.
The following drugs have similar pharmacological properties:
In 1 ml of solution articaine hydrochloride - 40 mg, epinephrine hydrochloride - 0.006 mg, which corresponds to 0.005 mg . Water for injection, sodium chloride, sodium sulfite - as excipients.
Release form
Solution in carpules in a metal container.
pharmachologic effect
Local anesthetic.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Combined preparation intended for local anesthesia for minor surgical interventions, including dentistry . Its action is determined by its constituent components.
Pharmacokinetics
Articaine has a high penetrating power. 95% protein bound. It practically does not penetrate the placental barrier, and is not excreted with a woman's milk. The half-life is 22-25 minutes.
Indications for use
Anesthesia for minor dental interventions:
- uncomplicated tooth extraction;
- filling of carious teeth;
- preparation for prosthetics (grinding of teeth).
For (retrobulbar , intercostal , paravertebral ), blockades (trigeminal nerve, stellate ganglion, brachial plexus, vulva).
Contraindications
- hypersensitivity to components;
- paroxysmal tachycardia ;
- and hypersensitivity to sulfites;
- angle-closure glaucoma ;
- concomitant therapy with non-selective beta-blockers , tricyclic antidepressants;
- heavy liver failure ;
- cardiogenic shock ;
Be careful with the following diseases and conditions:
- chronic heart failure ;
- inflammation in the area of anesthesia;
- weakened patients;
- elderly age.
Side effects
- headache, muscular, impaired breathing and consciousness (possible loss of it), muscle twitching, generalized convulsions are possible;
- nausea, vomiting;
- "clouding" in the eyes;
- drop in blood pressure, tachycardia , oppression of cardiovascular activity;
- redness of the skin, itching, swelling of the lips, glottis;
- swelling at the injection site;
- nerve damage.
Instructions for Ubistezin (Method and dosage)
It is used in practically healthy patients during dental interventions. On average, 1–1.5 cartridges are used at a time, which corresponds to 2–3 ml of solution. A maximum of 2 carpules are administered within 2 hours, a more accurate dose calculation is 7 mg / kg.
Uncomplicated tooth extraction- under the mucous membrane 1.7 ml per tooth. With a palatine incision, 0.1 ml. Anesthesia for tonsillectomy- 5-10 ml per tonsil, with suturing the perineum- 5-15 ml.
At conduction anesthesia(retrobulbar, intercostal, paravertebral, epidural, sacral), blockades (paracervical, trigeminal nerve, stellate ganglion, brachial plexus) from 1 to 30 ml of anesthetic is used, depending on the place and volume of anesthesia.
Instructions for Ubistezin forte
Ubistezin forte contains articaine 40 mg as well doseepinephrine 2 times more -10 mcg / ml. It is an anesthetic with an average content of vasoconstrictor, is the most effective of the painkillers. Ubistezin forte is used for long and complex extractions, with a large group of teeth. Recommended for use in apparently healthy patients. You can use 1–2 cartridges once, which corresponds to 2–4 ml of solution. A maximum of 2.5–3 carpules can be injected within 2 hours.
Overdose
Overdose is manifested by symptoms: dizziness, tachycardia or bradycardia, impaired consciousness, anxiety, lowering blood pressure.
It is necessary to stop the manipulation, lay the patient down and restore adequate airway patency, monitor blood pressure and heart rate. Inhalation of oxygen and artificial ventilation of the lungs are shown. In the presence of convulsions administered intravenously barbiturates ; at shocked- infusion electrolytes , glucocorticosteroids ; at vascular collapse- intravenously 0.1 mg; at tachycardia- intravenously selective beta blockers ; at increase in pressure- peripheral vasodilators .
Interaction
The anesthetic effect of the drug is enhanced by vasoconstrictor drugs.
Do not use Ubistezin during therapy with non-selective beta-blockers, as there is a risk hypertensive crisis And bradycardia .
Hypertensive effect epinephrine intensifies tricyclic antidepressants .
Terms of sale
Released by prescription.
Storage conditions
At temperatures up to 250 C.
Best before date
Analogues
Coincidence in the ATX code of the 4th level:Alfacain , Brilocaine-adrenaline , Brilocaine-adrenalineforte , Primakain , Ultracaine suprarenin , Cytopicture .
Ubistezin during pregnancy
During pregnancy, the use of this drug is possible. It does not pass through the placental barrier, so it is a safe anesthetic during this period. Does not have a negative effect on the fetus with any technique of use and dosage. Only possible bradycardia at the fetus. A nursing mother does not need to interrupt feeding, since the active substances are not excreted in milk in quantities significant for the child.
