Alcohol solution of iodine: instructions and use. Iodine: instructions for use Alcoholic iodine

One vial (10 ml) contains: active ingredient: iodine - 0.5 g, Excipients
One vial (800 ml) contains: active ingredient: iodine - 40 g, Excipients- potassium iodide, ethyl alcohol, purified water.
One vial (900 ml) contains: active ingredient: iodine - 45 g, Excipients- potassium iodide, ethyl alcohol, purified water.

Pharmacotherapeutic group

Antiseptic.
ATX code: D08AG03.

Pharmacological properties

Pharmacodynamics
Antiseptic. The main active ingredient is molecular iodine, which has antimicrobial and antifungal properties. Iodine is able to oxidize and denature the proteins of microorganisms, causing their death. Molecular iodine preparations are characterized by a pronounced local irritating effect on tissues, and in high concentrations - a cauterizing effect. When absorbed and entering the blood, it can have a systemic effect, participating in the synthesis of thyroid hormones.
Pharmacokinetics
Upon contact with the skin, 30% is converted into iodides, and the rest remains in the form of elemental iodine. Partially absorbed from the skin surface. The absorbed part can enter tissues and organs, being selectively absorbed by the thyroid gland. Iodine is excreted by the kidneys (mainly), intestines, sweat and mammary glands.
Absorption of iodine through damaged skin and mucous membranes can be significant.

Indications for use

It is used externally as an antiseptic for infectious and inflammatory diseases of the skin, for the treatment of the surgical field, for the prevention of infection of small damage to the integrity of the skin.

Contraindications

Individual intolerance (including history of hypersensitivity).
Patients with impaired thyroid function (hyperthyroidism and adenoma) or receiving lithium therapy.
Skin treatment for furunculosis, acne, hemorrhagic diathesis, urticaria, diabetic trophic ulcers is not allowed.
Duhring's dermatitis herpetiformis.
Neonatal period.

Dosage and administration

When applied externally, a cotton swab is moistened with a solution of iodine, which is used to treat the affected areas of the skin. Do not use the drug for more than 10 days. When processing the surgical field, the skin is wiped twice with a sterile gauze swab dipped in a solution of the drug. The total processing time is 4-6 minutes.

Side effect

Skin irritation, allergic reactions, including angioedema, urticaria, contact dermatitis, with prolonged use on extensive wound surfaces - "iodism" (lacrimation, hypersalivation, rhinorrhea, bronchorrhea, swelling of the mucous membranes).
May cause skin hemorrhages or purpura, fever, arthralgia, lymphadenopathy and eosinophilia.

Overdose

In case of an overdose, iodism, irritation and burns are possible.
When inhaling concentrated vapors - damage to the upper respiratory tract (burn, laryngo- and bronchospasm); if concentrated solutions get inside - severe burns of the digestive tract; in case of ingestion - the development of hemolysis, hemoglobinuria; the lethal dose is about 3 g.
Treatment: gastric lavage with 0.5% sodium thiosulfate solution, intravenous administration of 30% sodium thiosulfate solution - up to 300 ml. In case of a severe skin reaction to iodine, the drug should be removed immediately with 70% ethyl alcohol. It is also recommended to wash the skin with plenty of water for 15 minutes. In case of accidental swallowing, if the patient is conscious - milk inside every 15 minutes.
If the drug is not used to treat large open wounds or is used for no more than 10 days, clinically significant systemic absorption is unlikely. Systemic toxicity can lead to shock, tachycardia, fever, metabolic acidosis, and renal failure. Death can be caused by circulatory failure, epiglottis edema leading to asphyxia, aspiration pneumonia, or pulmonary edema.

Precautionary measures

It is not recommended to use the drug in children under two years of age due to an increased risk of hypothyroidism.
The undiluted drug should not be allowed to come into contact with the mucous membranes of the mouth, eyes, vagina and rectum.
It is not recommended for use in deep or puncture wounds, severe burns, as the use of the drug may cause excessive absorption of iodine and tissue irritation.
Do not use the drug for more than ten days!
It is not recommended to treat large areas of the skin with the drug.
The use of the drug may affect the results of thyroid function tests.

Pregnancy and lactation

Children

The use of the drug in newborns is contraindicated and the use of the drug in children under two years of age is not recommended due to the high probability of systemic absorption of iodine when applied topically.
Topical application in children can lead to severe skin reactions to iodine, iodism, transient hypothyroidism.

◊ Solution for external use alcohol 1% transparent, red-brown in color, with a characteristic odor.

Excipients: ethanol 95%.

15 ml - vials.

pharmachologic effect

Elemental iodine has strong antimicrobial properties. Elemental iodine preparations are characterized by a pronounced local irritating effect on tissues, and in high concentrations - a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Preparations that split off elemental iodine have a much less pronounced irritant effect, and iodides have local irritating properties only in very high concentrations.

The nature of the resorptive action of preparations of elemental iodine and iodides is the same. The most pronounced effect in the resorptive action of iodine preparations is on the function of the thyroid gland. With iodine deficiency, iodides contribute to the restoration of impaired synthesis of thyroid hormones. With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, the sensitivity of the thyroid gland to pituitary TSH decreases and its secretion by the pituitary gland is blocked. The effect of iodine preparations on metabolism is manifested by an increase in dissimilation processes. When they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of blood serum and slow down the rate of blood clotting.

Accumulating in syphilitic gums, iodine contributes to their softening and resorption. However, the accumulation of iodine in tuberculous foci leads to an increase in the inflammatory process in them. The excretion of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion. This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can cause lactation suppression.

Pharmacokinetics

Upon contact with the skin or mucous membranes, 30% turns into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates into tissues and organs and is selectively absorbed by the thyroid gland. It is excreted mainly by the kidneys, intestines, sweat and mammary glands.

Indications

For external use: infectious and inflammatory skin lesions, injuries, wounds, myalgia.

For local use: chronic tonsillitis, atrophic rhinitis, purulent, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

For oral administration: prevention and treatment of atherosclerosis, tertiary.

Contraindications

Hypersensitivity to iodine. For oral administration - pulmonary tuberculosis, nephritis, nephrosis, adenomas (including the thyroid gland), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, children under 5 years of age.

Dosage

When applied externally, iodine is used to treat damaged areas of the skin.

For oral administration, the dose is set individually, depending on the indications and the age of the patient.

Locally used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation into the ear and washing - for 2-4 weeks; in surgical practice and in case of burns, gauze wipes applied to the affected surface are moistened as needed.

Side effects

For external use: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, salivation, lacrimation, acne).

When taken orally: skin allergic reactions, tachycardia, nervousness, sleep disturbances, excessive sweating, diarrhea (in patients over 40 years of age).

Composition and form of release of the drug

◊ Solution for external use alcohol 5% transparent, red-brown in color, with a characteristic odor.

Excipients:, ethanol 95%.

10 ml - vials.
15 ml - vials.
25 ml - vials.

pharmachologic effect

Pharmacokinetics

Indications

For external use: infectious and inflammatory skin lesions, injuries, wounds, myalgia.

For local use: chronic tonsillitis, atrophic rhinitis, purulent, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

Contraindications

Hypersensitivity to iodine.

Dosage

When applied externally, iodine is used to treat damaged areas of the skin.

Locally used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation into the ear and washing - for 2-4 weeks; in surgical practice and when moistened as needed, gauze wipes applied to the affected surface.

Side effects

For external use: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).

drug interaction

Pharmaceutically incompatible with essential oils, white sedimentary mercury (an explosive mixture is formed). Alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity.

Iodine is a drug that has a locally irritating, anti-inflammatory, antiseptic, pronounced antimicrobial and, in high concentrations, a cauterizing effect. It has bactericidal activity against gram-positive and gram-negative microflora (especially Proteus spp., Escherichia coli and Streptococcus spp.), pathogenic fungi and yeasts. Causes the death of spores of the pathogen Bacillus anthracis.

Release form and composition

Dosage form Iodine - 5% alcohol solution.

Ingredients: iodine, potassium iodide, 95% ethanol, purified water.

Indications for use

According to the instructions for Iodine, indications for the use of the drug are:

For external use: abrasions, injuries, wounds, myalgia, infectious and inflammatory skin lesions, inflammatory infiltrates, myositis, neuralgia;
For local use: purulent otitis, atrophic rhinitis, chronic tonsillitis, varicose and trophic ulcers, wounds, chemical and thermal burns of I-II degrees, infected burns;
For oral administration: tertiary syphilis, atherosclerosis (treatment and prevention).

In addition, Iodine is used to disinfect the surgeon's fingers, the edges of wounds and the surgical field (before and after surgery), for antiseptic treatment of body parts during catheterization, puncture and injection.

Contraindications

Regardless of the method of application, iodine, according to the instructions, is contraindicated in case of hypersensitivity to the drug.

Inside the medicine is prohibited to take:

Children under 5 years old;
Pregnant women;
With pulmonary tuberculosis;
Patients with chronic pyoderma;
With nephritis and nephrosis;
With furunculosis and acne;
Patients with hemorrhagic diathesis;
With urticaria.

Method of application and dosage

When applied externally, iodine lubricates damaged or treated areas of the skin.

Place apply:

For washing the lacunae (recesses on the surface) of the tonsils and supratonsillar spaces (adjacent to the tonsils) - 1 procedure once every 2-3 days, a total of 4-5 procedures are performed;
For irrigation of the nasopharynx - 2-3 times a week, treatment - up to 3 months;
For instillation into the ear and washing - as directed by a doctor;
For gargling - several times a day with an aqueous solution (5 ml of iodine per 50 ml of water);
In surgical practice and for burns - as needed, gauze wipes soaked in Iodine are applied to the affected areas.

If it is necessary to take Iodine orally, the doctor sets the dose in each case individually. The required amount of the drug should be dissolved in milk, taken after meals.

For the prevention of atherosclerosis, adults are prescribed 1-10 drops once or twice a day for 30 days. It is recommended to conduct 2-3 such courses per year. In the treatment of atherosclerosis, usually take 10-12 drops three times a day. With tertiary syphilis, a single dose varies from 5 to 50 drops; Iodine solution should be taken 2-3 times a day.

The maximum single dose for adults is 20 drops, the daily dose is 60 drops.

Children inside Iodine is prescribed 3-5 drops per 1/2 cup of milk 2-3 times a day.

Side effects

In most cases, the drug is well tolerated.

When Iodine is taken orally, skin allergic reactions, excessive sweating, sleep disturbance, diarrhea, nervousness, tachycardia can occur, and when taken in high concentrations, a chemical burn occurs.

When applied externally, iodine sometimes causes skin irritation. With hypersensitivity to the drug and with prolonged use on large areas of the body, there is a possibility of developing iodism, manifested by acne, lacrimation, salivation, urticaria, cough, rhinitis, metallic taste in the mouth, thirst, Quincke's edema, diarrhea, general weakness.

special instructions

Iodine is pharmacologically incompatible with white sedimentary mercury, ammonia solutions and essential oils. Such combinations are strictly contraindicated!

Iodine reduces the hypothyroid and strumagenic effects of lithium preparations, and its antiseptic activity is weakened by acidic and alkaline environments, the presence of blood, pus and fat.

The drug should be used very carefully to prevent the solution from getting into the eyes.

High temperature (more than 40 ºС) and light accelerate the decomposition of active iodine.

The diluted solution is not subject to long-term storage.

Analogues

The following medicines belong to the same pharmacological group (“Iodine preparations”) and are characterized by a similar mechanism of action: Aquazan, Braunodin B. Brown, Brownodin B. Brown Povidone-Iodine, Betadine, Yod-Ka, Iodinol, Iodine tablets, Yodovidon, Yodonat , Iodopiron, Iodoflex, Ioduxun, Lugol, Lugol's solution with glycerin, Povidone-iodine, Octasept, Stellanin, Stellanin-PEG, Suliodovizol, Suliodopirone.

Terms and conditions of storage

According to the instructions, the drug should be stored in a dark place at a temperature not lower than 0 ºС. The shelf life of the solution is 3 years.

Description

Transparent liquid of red-brown color with a characteristic smell.

Pharmacotherapeutic group

Antiseptics and disinfectants. Iodine preparations.

ATX code D08AG03

Pharmacological properties

Antiseptic. The main active ingredient is molecular iodine, which has antiseptic properties. When applied to large areas of the skin, iodine has a resorptive effect: it affects the function of the thyroid gland. Local action is due to the ability of elemental iodine to precipitate tissue proteins. The drug that splits off elemental iodine has a much less pronounced irritant effect. The effect of the drug on metabolism is manifested by an increase in dissimilation processes.

Indications for use

For local use in surgical practice

Treatment of abrasions, cuts, small wounds

Dosage and administration

Outwardly, treat damaged areas of the skin. Locally: when processing the surgical field, the skin is wiped twice with a sterile gauze swab dipped in a solution. The total processing time is 4-6 minutes. For topical application, gauze wipes are pre-moistened with iodine solution, applied to the affected skin surface for at least 2 minutes.

Side effects

Allergic reaction to iodine (skin itching, hyperemia, urticaria, skin irritation)

Quincke's edema, intradermal hemorrhages, purpura

Fever, arthralgia, lymphadenopathy, eosinophilia

Contraindications

Hypersensitivity to iodine

Thyroid disease

Use concomitantly with lithium preparation

Dermatitis herpetiformis

Drug Interactions

The use of iodine affects the results of thyroid function tests. Pharmaceutically incompatible with essential oils, enzymes. Alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity of the drug.

special instructions

Avoid prolonged use.

For external use only.

Do not cover iodine solutions applied to the skin with occlusive dressings.

Do not use on large, open wounds.

When combined with yellow mercury ointment, the formation of mercury iodide, which has a cauterizing effect, is possible.

Application in pediatrics

Pregnancy and lactation

It is possible to use the drug as directed by a doctor.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Does not affect

Overdose

Do not take internally! In case of accidental ingestion.

Symptoms: unpleasant metallic taste in the mouth, vomiting, abdominal pain, diarrhea, thirst, headache. The lethal dose of iodine is 2-3g. Treatment: symptomatic treatment of allergic reactions; in case of acute poisoning, abundant consumption of milk and vegetable starch, activated charcoal, the use of sodium thiosulfate solution is recommended.

1% or 5%. The lack of electrolytes and water must be replaced.

Pethidine or morphine sulfate can be used for pain relief only under medical supervision. If necessary, tracheotomy.