Codelac prescription. Composition and features of the use of Codelac preparations for dry cough: a review of instructions, reviews and analogues for children and adults

The Codelac cough line today has a diverse composition of active ingredients: Phyto tablets and syrup based on Codeine (Pharmstandard), as well as a series of products with another active substance - Butamirate citrate (OTCPharm).

All remedies very effectively relieve obsessive coughing fits by suppressing the development of infection, as well as accelerating the liquefaction of sputum, mucous secretion that accumulates in the respiratory organs.

Description of drugs

General medicinal properties: due to the effect on neurons, drugs reduce the intensity and frequency of unproductive cough. Codelac® Cough Tablets and Codelac® Phyto Elixir are designed to relieve unproductive (without sputum production) and unproductive cough.

The drugs are highly effective in rapid suppression. However, they are unsafe for long-term use due to the content of codeine, which is addictive. They have many contraindications and side effects, so they are usually not prescribed for small patients under 12 years of age.

A series of drugs Codelac (Butamirat): NEO, Broncho, Pulmo in drops, syrups, creams, safer to use because they do not contain codeine. Means are allowed for use from the age of 2 months. When suppressing reflex urges, the hyperreactivity of the mucous membranes of the respiratory organs is reduced in relation to irritating external factors.

Clinical and pharmacological group

A group of drugs with a central effect with pronounced antitussive, as well as expectorant and analgesic properties. Cough tablets and syrups Codelac® Phyto based on codeine are products containing opium alkaloids. A series of drugs Neo, Broncho, Pulmo does not belong to narcotic drugs.

The effectiveness of drugs depends little on the totality of active ingredients, however, it should be taken into account according to the criteria for the treatment of patients with weakened immunity. It is important to know what can cause addiction.

Table of release forms and compositions

Names Main active ingredient Additional medicinal ingredients
Codelac® cough tablets. The content of substances in 1 pc.

In a contour package 10 pcs. or in 1 box 2 blisters.

Codeine (8 mg). Licorice Root (200mg), Sodium Bicarbonate (200mg), Thermopsis (20mg).
Phyto, syrup. Composition per 5 ml.

Dark glass bottles of 100, 125, 50 ml.

Codeine (4.5 mg). Thermopsis (10 mg), thyme (liquid extract 1 gr.),

Licorice (200 mg).

Neo drops.

Bottle with dropper 20 ml 440 dosed drops.

Butamirate citrate (100 mg). Ethanol, sorbitol syrup, glycerol, sodium hydroxide, benzoic acid, sodium saccharinate, water.
Neo syrup, 5 ml

Dark bottles 100, 200 ml.

The box contains convenient spoons for volumes of 2.5 and 5 ml.

Butamirate citrate (7.5 mg). Ethanol, sorbitol syrup, sodium saccharinate, glycerin, sodium hydroxide, benzoic acid, vanillin, water,
Neo, in 1 tablet.

The box contains a blister with 10 tablets.

Butamirate citrate (50 mg). Lactose, silicon dioxide, hypromellose, povidone, magnesium stearate, talc, maltodextrin, titanium dioxide, polydextrose.
Broncho in the form of an elixir with thyme, 5 ml.

Vials dark 100, 200 ml.

Tablets 10 pcs. in blister

In syrup: Ambroxol (10 mg), sodium glycyrrhizinate (30 mg), liquid thyme extract (500 mg).

In tablets:

Ambroxol (20 mg), thermopsis (10 mg), sodium glycyrrhizinate (30 mg), sodium bicarbonate (200 mg).

In syrup: Nipagin, sorbitol, nipasol, water.

In tablets:

potato starch, povidone (K 25), sodium starch glycolate, cellulose,

Pulmo gel.

Tube plastic 50 ml.

Gum turpentine, camphor, vegetable oils, fir extract, aristoflex, germaben, red pepper, PEG 400. Nipagin, sorbitol, nipazole, water, glycerin, stearic acid, talc.

Codelac tablets are allowed to be taken from the age of 18, Codelac syrup and elixirs from 2-3 years old, drops - from 2 months from birth.

pharmachologic effect

All combined antitussive drugs Codelac are intended for use to reduce the excitability of the neuroreceptors of the cough center of the human brain. As well as the normalization of the process of mucus formation in the bronchi: it stabilizes the improvement of liquefaction of sputum and the acceleration of its rejection from the respiratory system.

How medicinal components work:

  • Alkaloids cause an expectorant effect, activate the formation, rejection of sputum.
  • Codeine - reduces the excitability of neurons, has an analgesic effect, stops attacks of dry cough.
  • Sodium bicarbonate thins mucus, reducing its viscosity.
  • Licorice softens the inner epithelium, relieves muscle spasms, stops the inflammatory process. Accelerates the liquefaction of sputum.
  • with vegetable essential oils helps to accelerate sputum rejection, has an antibacterial and anti-inflammatory effect.
  • Butamirate is characterized by a bronchodilating effect (expands the bronchi). Reduces the frequency and intensity of coughing.
  • has a secretolytic, secretomotor, expectorant effect, does not depress the respiratory center.
  • Glycyrate is distinguished by antimicrobial, anti-inflammatory, anti-allergic abilities.

All Codelac preparations, when coughing, stimulate the rejection and disinfection of the mucosa, sputum infected with microbes from the respiratory organs. Actively acting on the cough central center, they suppress reflex urges.

The maximum time for the onset of action of the Codelac cough remedy: from half an hour to an hour. The duration of drug efficacy of one dose of the drug is 6 hours.

Indications for use

Depending on the composition of Codelac preparations, drugs, according to the instructions, are prescribed to cure unproductive and wet cough in diseases of the respiratory system of various nature:

  • SARS.
  • Flu.
  • Laryngitis.
  • Bronchitis.
  • COPD smokers.
  • Pneumonia.

Codelac cough is also prescribed in the postoperative periods, in order to reduce the risk of rupture of the sutures (from stress).

Contraindications

It is not allowed to use Codelac for coughing in the following cases:

  • With asthma.
  • During periods of acute respiratory failure.
  • If you are allergic to the ingredients of the drugs.
  • In cases of bronchiectasis.

Medicines with codeine, as well as tablets with butamirate, are prohibited for children under 18 years of age and women who are pregnant, as well as breastfeeding babies.

Instructions for use

Codelac line preparations for coughing are allowed to be used for treatment only when prescribed by a doctor, since the methods and dosages of drugs are individual.

General consumption rates are shown in the table.

Name Dosages for the children's group Norms for adults special instructions
Codelac® tablets Only from 18 years old 1 tablet 2 or 3 times a day. The norm of codeine is not higher than 0.2 g per day. Single dose - no more than 0.05 g.

After meal.

Phyto 2-5 year olds: 5 ml.

From 5 years - 8-10 ml.

8-12 year olds: 15 ml

Over 12 years old from 15 to 20 ml. In between meals.
neo drops 2 months up to a year: 4 times a day, 10 drops.

1-3 gr. 15 cap.

From 3 years of age 25 cap.

Not applicable Before meals.

The number of drops in 1 ml is 22 units.

Neo Elixir 3-6 years: 3 doses of 5 ml.

6-12: 3 times 10 ml.

12 years and over: 3 servings of 15 ml.

4 doses of 20 ml. Before eating. Use the measuring spoon from the box.
Neo and Broncho tablets It is forbidden. 1 PC. with an interval of 8 to 10 hours Before eating, do not chew.

broncho elixir

2-6 years old: 3 doses of 0.5 measuring l.

6-12 years old: 3 times 1 scoop.

Adults and children over 12 years old - 10 ml 4 times a day. Before eating.

Fill measuring spoon.

Pulmo gel From 3 years to 12, lubricate the back with a thin film 1-2 times. From 12 years old 2-3 times a day. With the formation of hyperemia, rash on the skin, discontinue use.

If the cough does not disappear after 5 days, you need to contact the doctor again.

If the cough does not go away after 5 days, you should consult a doctor

special instructions

Codelac medicines are used with caution for coughing in the following situations:

  • If the patient has intracranial pressure.
  • With hypersensitivity to any component.
  • People with heart and lung failure.
  • With diseases of the kidneys and gastrointestinal tract.

You should not take the drug Codelac before traveling by transport as a driver, since the drug has a pronounced sedative effect.

Reception during pregnancy and lactation

The use of tablets is not allowed. Treatment with syrups only when prescribed by a doctor.

Drug incompatibility and interaction

Simultaneous consumption with drugs that cause CNS depression is prohibited:

  • Sleeping pills.
  • Antipsychotics.
  • Analgesics.
  • Antihistamines.
  • Tranquilizers.
  • Cardiac glycosides.
  • adsorbent substances.
  • Expectorants.

It is forbidden to drink alcohol for the entire period of treatment.

Overdose

In case of excessive consumption of Codelac, the following dangerous symptoms may occur when coughing:

  • Drowsiness.
  • Confused respiratory rhythm or its slowdown.
  • Bradycardia or arrhythmia.
  • Skin itching, rash.
  • Atony of the intestine or bladder.
  • Vomit.

It is necessary to immediately do a gastric lavage, call an ambulance.

Side effects

Individual intolerance can be expressed by undesirable symptoms:

  • Allergic dermatitis.
  • Constipation, nausea, diarrhea.
  • Headaches, pain in the eyes, drowsiness.
  • Dizziness, lethargy.

Be sure to tell your doctor about any discomfort. You may need to stop taking Codelac and replace it with another drug.

Terms and conditions of storage

Shelf life and storage periods depend on the form of release:

  • Tablets - 4 years at a temperature not exceeding 25 degrees.
  • Syrups are stored from six months to a year, the temperature is 12-16 degrees.
  • Drops in a closed vial - 2 years, open - 15 days.

Syrups and drops should be kept inside the refrigerator.

Market prices

The average cost of Codelac preparations is expressed by the following figures:

Minimum prices for cough medicines are indicated.

The following pharmaceuticals have the same medicinal effect:

All antitussive drugs of the Codelac line are highly effective, have a quick expectorant effect. However, the appropriateness of treatment is determined by the doctor, self-medication can be harmful. Uncontrolled use is especially dangerous for children, the elderly and people with weakened immune systems.

With the beginning of autumn, the number of colds increases sharply. If the autumn is also cold, windy and rainy, the number of people coughing and blowing their nose reaches a critical size.

At this time, the demand for medicines for the common cold and is increasing. We all want to find a remedy that will have the most natural composition, while being very effective. One of the most popular cough medicines is Codelac.

At the beginning of a cold, the patient is pestered by dry, barking, sometimes indomitable, which doctors call unproductive. This name is due to the fact that with such a cough, sputum is not formed, which alleviates the condition of a sick person.

The purpose of using drugs for non-productive cough is to cause the production of sputum and increase its separation. Due to this, the patient's condition will improve, he will suffer less from coughing attacks, and sputum will be easily expectorated, accelerating the patient's recovery.

Codelac cough is a combination remedy based on codeine and plant extracts.

It has an active property to act on, reducing its frequency and strength. The drug has an excellent effect on dry non-productive cough, contributing to the active removal of sputum.

The medicine helps with different types of colds, regardless of what caused the disease - a virus, bacteria or fungi. It helps to cope with an acute condition and prevent the spread of pathogens during severe coughing and sneezing.

There are several forms of drug release, the appointment of which depends on many reasons - the age of the patient, his susceptibility and preferences.

Codelac can be produced in the form and, in the form of Codelac Broncho and Codelac with thyme. The main composition of the remedy is the same, only in some of them other medicinal substances are added to enhance its effect.

Dosage and application

Adults and adolescents from 12 years of age are prescribed Codelac for cough, 1 tablet 2 or 3 times a day for several days. Abuse of the drug should not be in order to avoid addiction.

If the medicine is in the form of a syrup, it is taken 10 ml up to 4 times a day, with or immediately after meals, to avoid digestive problems. If the patient has problems with the kidneys, the drug should be taken less frequently - codeine in Codelac is slowly excreted by diseased kidneys.

For children, this medicine is usually prescribed in the form of a syrup, since babies do not like to swallow tablets, and it can be dangerous if the child coughs all the time - he can inhale the medicine.

Syrup is given to babies strictly dosed, depending on age:

  • From 2 to 5 years - 5 ml per day.
  • From 5 to 8 years - 10 ml per day.
  • From 8 to 12 years - 10 - 15 ml per day.
  • From 12 to 15 years - 15 - 20 ml per day.

In order not to expose yourself to the risk of addiction, Codelac should not be used for more than 5 days in a row.

If you need to continue treatment, you should consult with your doctor.

Do not self-administer this remedy, especially to young children. You don’t know how a baby’s body can react to this medicine, and it’s better for an adult not to risk health. Consult with your doctor, it is easier for him to assess the possible benefits or harms of this drug.

Use during pregnancy

The use of the drug during pregnancy and while breastfeeding is prohibited. The use of codeine-based products can adversely affect both the course of pregnancy and the health of the fetus.

The risk of taking the drug is not justified by its action, since the modern pharmacopoeia offers many cough medicines that do not affect either the pregnant woman or the fetus or newborn. The doctor will select a remedy that will be harmless to the mother and fetus or baby, but will be useful against coughing.

Contraindications Codelac

Codelac cough, like many other drugs, has some contraindications:

  • breastfeeding period
  • Children under 2 years old
  • Bronchial asthma
  • Respiratory dysfunction
  • Reception of alcoholic beverages
  • Concomitant use of centrally acting analgesics
  • Sensitivity or allergies to drug components

Before taking this drug, analyze your own health and exclude the possibility of side effects. If there is any doubt about the safety of the drug, consult your doctor if the effectiveness of the drug can justify the possible risk of its use.

Particular care should be taken when using the drug for people suffering from allergies.

Since the product contains extracts and extracts from plant materials, the risk of allergic reactions can be very high. The use of codeine in Codelac can be very dangerous for people suffering from chronic respiratory problems, especially constrictions.

Codeine causes depression of the respiratory center, which in people with breathing problems can provoke an attack of suffocation.

Side effects

A side effect that can cause the use of Codelac is:

  1. Habituation and, as a consequence, drug dependence. Codeine can quickly cause the need to increase the dose of the drug, and this is very dangerous and can lead to respiratory arrest.
  2. The medicine may cause nausea and vomiting. Basically, these phenomena are caused by plant extracts such as licorice root, which have a sweet, sugary taste. Mostly these symptoms are experienced by people with a sensitive stomach or who have some kind of digestive system disease.
  3. A clear manifestation of side effects is allergic reactions. Most often they are manifested by a skin rash - urticaria, accompanied by redness, swelling and severe itching.
  4. In some people, the composition of the drug may cause lethargy, drowsiness, impaired attention and concentration. Taking the medicine limits the management of transport or work with complex devices. The risk of dangerous violations increases with increasing doses of the drug.
  5. Headache is a frequent companion of codeine-based medications, especially in people with fragile sensitive vessels and low blood pressure.
  6. In some cases, instead of indigestion, constipation is observed.

If at least one of the listed side effects appears while taking the medicine, it should be canceled and the doctor should be informed about the incident. He will be able to find a harmless replacement for the drug.

In this article, you can read the instructions for using the drug Codelac. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Codelac in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Codelac in the presence of existing structural analogues. Use for the treatment of cough in adults, children, as well as during pregnancy and lactation.

Codelac- an antitussive preparation of a combined composition.

Codeine has a central antitussive effect, reduces the excitability of the cough center. When used in doses exceeding those recommended, to a lesser extent than morphine, it depresses respiration, inhibits intestinal motility, rarely causes miosis, nausea, and vomiting, but can cause constipation. In small doses, codeine does not cause respiratory depression, does not impair the function of the ciliated epithelium, and does not reduce bronchial secretions. Long-term use of codeine can cause drug dependence.

Thermopsis herb contains isoquinoline alkaloids that excite the respiratory center and stimulate the vomiting center. Herb thermopsis has a pronounced expectorant effect, manifested in an increase in the secretory function of the bronchial glands, increased activity of the ciliated epithelium and accelerated secretion evacuation.

Sodium bicarbonate changes the pH of bronchial mucus to the alkaline side, reduces the viscosity of sputum, and to a certain extent also stimulates the motor function of the ciliated epithelium.

Licorice root has an expectorant effect due to the content of glycyrrhizin, which stimulates the activity of the ciliated epithelium in the trachea and bronchi, and also enhances the secretory function of the mucous membranes of the upper respiratory tract. In addition, licorice root has an antispasmodic effect on smooth muscles, because. contains flavone compounds.

The drug promotes the evacuation of mucus from the respiratory tract when coughing, weakens the cough reflex. The maximum effect occurs 30-60 minutes after ingestion and lasts 2-6 hours.

Indications

  • symptomatic therapy of dry cough of various etiologies in bronchopulmonary diseases.

Release form

Pills.

Syrup Codelac Phyto.

Tablets Codelac Broncho.

Elixir Codelac Broncho with thyme.

Instructions for use and dosing regimen

Pills

The drug is prescribed orally, 1 tablet 2-3 times a day for several days. Treatment should be short.

It should be borne in mind that the maximum doses of codeine for adults when taken orally are: single - 50 mg, daily - 200 mg.

In patients with impaired renal function, the excretion of codeine is slowed down, therefore it is recommended to increase the interval between doses of Codelac.

Syrup

The drug is prescribed orally depending on age:

  • Children 2-5 years old - 5 ml;
  • Children 5-8 years old - 10 ml;
  • Children 8-12 years old - 10-15 ml;
  • Children 12-15 years old and adults - 15-20 ml.

The daily dose should be divided into 2-3 doses.

The drug should be taken between meals. Treatment should be short (several days).

Elixir with thyme

It is taken orally during a meal, with a small amount of water.

Adults and children over 12 years old - 10 ml 4 times a day.

Children aged 2 to 6 years are prescribed 2.5 ml 3 times a day, aged 6 to 12 years - 5 ml 3 times a day.

The maximum duration of treatment without consulting a doctor is 5 days.

Side effect

  • nausea, vomiting;
  • constipation;
  • headache;
  • drowsiness;
  • skin itching;
  • hives;
  • with prolonged use, the development of drug dependence on codeine is possible.

Contraindications

  • respiratory failure;
  • bronchial asthma;
  • pregnancy;
  • lactation period (breastfeeding);
  • children's age up to 2 years;
  • taking centrally acting analgesics (buprenorphine, nalbuphine, pentazocine);
  • alcohol intake;
  • hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

special instructions

Use the drug with caution in patients with increased intracranial pressure.

Long-term treatment with the drug in high doses can lead to the development of drug dependence.

Do not prescribe Codelac simultaneously with mucolytic and expectorant drugs.

Before prescribing antitussives, the cause of the cough should be clarified and the need for special treatment determined.

It should be borne in mind that the drug is doping, because. contains codeine (which is a narcotic analgesic).

Influence on the ability to drive vehicles and control mechanisms

Due to the possibility of developing a sedative effect, during treatment it is not recommended to engage in activities that require increased attention and speed of psychomotor reactions.

drug interaction

Simultaneous use with other drugs that depress the activity of the central nervous system due to increased sedative effect and inhibitory effect on the respiratory center with hypnotics, sedatives, antihistamines, centrally acting analgesics, anxiolytics, antipsychotics is not recommended.

Chloramphenicol inhibits the biotransformation of codeine and thereby enhances its action.

When Codelac is used in large doses, the effect of cardiac glycosides (including digoxin) may increase, because. with the weakening of peristalsis, their absorption increases.

Adsorbents, astringents and coating agents can reduce the absorption of codeine, which is part of the drug, from the gastrointestinal tract.

Analogues of the drug Codelac

Structural analogues for the active substance:

  • Cough tablets.

Analogues by pharmacological group (antitussives in combinations):

  • Alex Plus;
  • Bronchitusen Vramed;
  • Broncholine sage;
  • Broncholitin;
  • Bronchoton;
  • Bronchocin;
  • Glycodin;
  • Codelmixt;
  • Codipront;
  • Codterpin;
  • Cofanol;
  • Libeksin;
  • Neo-Codion;
  • Omnitus;
  • Padevix;
  • paracodamol;
  • Rengalin;
  • Tedein;
  • Terasil-D;
  • Terkodin;
  • Terpincode;
  • Tussin plus;
  • Fervex for dry cough.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

ABON BIOPHARM(Hangzhou) Co.,LTD I.D.T. Biological GmbH BIOLIT CO., LTD. Biotechnos S.A. THFZ ICN Pharmstandard, OOO Pharmstandard-Leksredstva OJSC Pharmstandard-Tomskchimpharm, OJSC Pharmstandard-Ufimsky Vitamin Plant, OJSC

Country of origin

Russia

Product group

Respiratory system

A drug with mucolytic, expectorant and anti-inflammatory action

Release form

  • 10 - cellular contour packs (1) - packs of cardboard. 10 - blister packs (2) - packs of cardboard 10 - packs of blister packs (1) - packs of cardboard. 10 - cellular contour packs (2) - packs of cardboard. 10 pieces. - cellular contour packings (1) - packs of cardboard. 100 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 50 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 100 ml - dark glass bottles (1) complete with a measuring spoon - packs of cardboard. 125 ml - dark glass bottles, 100 ml bottle 20 ml each in dark (amber) glass dropper bottles. One bottle together with instructions for use in a pack of cardboard. 200 ml vial tube 50 ml in ind/pk vial 200 ml in ind/pk with measuring spoon.

Description of the dosage form

  • drops for oral administration. colorless liquid with vanilla odour. gel Gel with essential oils of coniferous trees liquid from light brown to brown. Precipitation may occur during storage. Brown syrup with a characteristic aromatic odor. Tablets are yellow to brown with white to dark brown patches. Tablets from light cream to cream with a yellowish tinge in color with darker and lighter patches, flat-cylindrical, with a risk and a chamfer. Tablets with modified release, film-coated, white, round, biconvex; on a cross section of a tablet of white or almost white color.

pharmachologic effect

Thanks to the balanced composition of biologically active substances, CODELAK® PULMO gel: - helps to improve the blood supply to the tissues of the broncho-pulmonary system; - has a locally irritating, "distracting" effect; - promotes sputum discharge and reduction of congestion in the bronchopulmonary system, thereby facilitating cough; - stimulates the protective functions of the body and can be used in case of hypothermia as a means for a preventive general strengthening massage. The components of the gel have an anti-inflammatory and bactericidal effect, have a beneficial effect on the respiratory tract due to a sufficiently high concentration of vapors of essential oils and other components of the gel in the inhaled air (aromatherapy). This makes it possible to use CODELAC® PULMO gel in acute respiratory infections and other respiratory diseases, including to relieve cough and improve sputum discharge. The composition of CODELAC® PULMO includes natural components obtained from coniferous plants growing in ecologically clean areas of Siberia. The properties of CODELAC® PULMO gel are due to the complementary action of its constituent components. Fir oil has a complex effect due to the content of a large number of biologically active compounds that determine its anti-inflammatory, antiseptic, tonic and improves blood circulation effects. Fir oil has a local irritating effect, helps to improve microcirculation, the essential oils included in its composition can have a bactericidal effect. Due to the complex anti-inflammatory and bactericidal action, fir oil is used for diseases of the upper respiratory tract, for acute respiratory infections. Camphor, affecting the nerve endings of the skin, causes a reflex expansion of blood vessels and blood flow to the area of ​​application, as well as to the tissues of the bronchi and lungs, improving their nutrition and oxygen saturation, facilitating sputum discharge. These properties of camphor determine its local irritating, distracting, local analgesic, anti-inflammatory and moderate expectorant action. In addition, camphor also has an antiseptic effect. Camphor is widely used for colds and inflammatory diseases, including to relieve cough and improve sputum discharge. Turpentine has a "distracting", analgesic and antiseptic effect, therefore it is used as part of a number of ointments, including in the initial stages of diseases of the upper respiratory tract.

Pharmacokinetics

Absorption After oral administration, butamirate is rapidly and completely absorbed from the gastrointestinal tract. After taking 150 mg of butamirate, the maximum concentration of the main metabolite (2-phenylbutyric acid) in blood plasma is reached after about 1.5 hours and is 6.4 μg / ml. Distribution and metabolism Hydrolysis of butamirate initially to 2-phenylbutyric acid and diethylaminoethoxyethanol begins in the blood. These metabolites also have antitussive activity and, like butamirate, are highly (about 95%) bound to plasma proteins, resulting in their long half-life. 2-phenylbutyric acid is partially metabolized by hydroxylation. With repeated administration of the drug, cumulation is not observed. Withdrawal The half-life of butamirate is 6 hours. Metabolites are excreted mainly by the kidneys. Moreover, 2-phenylbutyric acid is mainly excreted in the form associated with glucuronic acid.

Special conditions

* prolonged treatment with high doses may lead to dependence on the drug; * you should not prescribe Codelac phyto simultaneously with mucolytic and expectorant drugs; * before prescribing antitussives, the cause of the cough should be clarified due to the possible need for special treatment; * due to the possibility of developing a sedative effect, during treatment it is not recommended to engage in activities that require increased attention, speed of mental and motor reactions; * Athletes should remember that the drug contains codeine and is doping; * care must be taken in case of increased intracranial pressure; * in patients with impaired renal function, the excretion of codeine is slow, so it is recommended to lengthen the intervals between doses of the drug; * Do not drink alcohol while taking Codelac® Phyto.

Compound

  • 1 tab. butamirate citrate 50 mg Excipients: lactose monohydrate - 241 mg, hypromellose - 85 mg, talc - 4 mg, magnesium stearate - 4 mg, colloidal silicon dioxide 6 mg, low molecular weight povidone 5 mg. ambroxol hydrochloride 10 mg sodium glycyrrhizinate 30 mg thyme liquid extract 500 mg Excipients: methyl parahydroxybenzoate (nipagin), propyl parahydroxybenzoate (nipazole), sorbitol (sorbitol), purified water. ambroxol hydrochloride 20 mg sodium glycyrrhizinate 30 mg dry extract of thermopsis 10 mg sodium bicarbonate 200 mg Excipients: potato starch, microcrystalline cellulose, povidone K25 (kollidon K25), talc, stearic acid, sodium carboxymethyl starch (sodium starch glycolate, primogel). butamirate citrate (in terms of 100% substance) - 100 mg; Excipients: sorbitol (Neosorb 70/70 V, sorbitol syrup) 8100 mg, glycerol (glycerol) 5800 mg, ethanol 96% (ethyl alcohol) 60 mg, sodium saccharinate 23 mg, benzoic acid 23 mg, vanillin 23 mg, sodium hydroxide 30% solution (sodium hydroxide) 10 mg, purified water up to 20 ml. water, fir oil, glycerin, racemic camphor, vegetable oil, red pepper extract, PEG 400 aristoflex, vinylin. codeine phosphate 4.5 mg dry extract of thermopsis 10 mg thick extract of licorice root 200 mg liquid extract of thyme 1 g Excipients: sorbitol, nipagin, nipazole, water. per 5 ml: Active substance: butamirate citrate - 7.5 mg; Excipients: sorbitol (Neosorb 70/70, sorbitol syrup) 2025.0 mg, glycerol (glycerin) 1450.0 mg, ethanol 96% (ethyl alcohol) 12.5 mg, sodium saccharinate 3.0 mg, benzoic acid 5, 75 mg, vanillin 3.0 mg, sodium hydroxide solution 30% (sodium hydroxide) 1.55 mg, purified water up to 5 ml.

Codelac indications for use

  • to eliminate dry cough in children from 2 months; Dry cough of any etiology, including whooping cough; to suppress cough in the preoperative and postoperative period, during surgical interventions and bronchoscopy.

Codelac contraindications

  • - pregnancy; - lactation period (breastfeeding); - children's age up to 2 years; - Hypersensitivity to the components of the drug. The drug should be used with caution in patients with hepatic and / or renal insufficiency, peptic ulcer of the stomach and duodenum, bronchial asthma.

Codelac dosage

  • 1.5 mg/ml 5 mg/ml

Codelac side effects

  • From the side of the central nervous system: rarely - weakness, headache. From the digestive system: rarely - diarrhea, dry mouth, constipation; with prolonged use in high doses - gastralgia, nausea, vomiting. From the respiratory system: rarely - dryness of the mucous membrane of the respiratory tract, rhinorrhea. Other: rarely - dysuria, exanthema, allergic reactions.

drug interaction

It is undesirable to use with other drugs that depress the activity of the central nervous system, due to increased sedative effect and inhibitory effect on the respiratory center: hypnotics, sedatives, antihistamines, narcotic analgesics, morphine derivatives, anxiolytics, antipsychotics. Codeine enhances the effect of ethanol on psychomotor function. Chloramphenicol inhibits the biotransformation of codeine in the liver and thereby enhances its action. When codeine is used in high doses, the effect of cardiac glycosides (digoxin, etc.) may increase, since their absorption increases due to the weakening of peristalsis. Adsorbents, astringents and coating agents can reduce the absorption of codeine, which is part of the drug, in the gastrointestinal tract.

Overdose

Symptoms: drowsiness, vomiting, headache, itching, miosis, depression of the respiratory center, bradypnea, arrhythmias, bradycardia, urinary retention, bladder atony. Symptomatic treatment, including restoration of breathing and cardiovascular activity, gastric lavage

Storage conditions

  • store in a dry place
  • keep away from children
  • store in a place protected from light
Information provided

Cough is a debilitating symptom, for the treatment of which the Codelac line of drugs is recommended.

Instructions for use contains complete data on the composition, dosage and method of application of each product manufactured under this brand.

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Release forms Codelac and their composition

The name is a collective name for funds that have a different composition and are available in several dosage forms Codelac. The instruction describes the complete list of components and their quantity. The table lists the most important ingredients.

Table 1. Composition of Codelac and dosage forms of the drug

ComponentDecryption

Codelac for dry cough (codeine)

Active substances

CodeineOpium alkaloid, which has an analgesic effect and depresses the cough center
thermopsisExpectorant, accelerating the movement of the cilia of the epithelium of the respiratory system
drinking sodaDisinfectant and acid neutralizer
Liquorice rootExpectorant, emollient, relieves inflammation

Active ingredient

ButamiratSuppresses the cough center, produces an expectorant effect, stops inflammation, expands the bronchi

Additional Ingredients

syrup/drops

SorbitolSweetener, recommended with caution in diabetes mellitus. Included in Codelac cough, but can cause allergies
ethanolAlcohol is prohibited in alcoholism, intolerance and in childhood

Pills

Lactose monohydrateFiller. Forbidden for people with lactose intolerance
TalcStabilizer, filler, preservative. Toxic in high doses

Active ingredient

AmbroxolMucolytic, produces a secretory and secrolytic effect. Has an expectorant effect
thermopsis-
GlycyrrhizinIt is extracted from licorice root. Stops inflammation, relieves swelling, has an expectorant effect
drinking soda-

Recipes in Latin

Analogue drugs can have many names. The name Codelac also belongs to the trademark. A prescription in Latin will help you not to get confused in a pharmacy when choosing medicines that have the same composition of active substances. Consider the names of the active substances entered into the prescription form.

Table 2. Composition of Codelac in Latin for each type of drug

NameCompound
With codeineCodeini/Natrii hydrocarbonatis/radicum/Glycyrrhizae/herbae Thermopsidis lanceolatae
NeoButamirati
bronchoAmbroxoli/Natrii glycyrrhizinatis/herbae Thermopsidis lanceolatae

Codelac with codeine for dry cough

In 2012, Russia introduced a ban on the free sale of drugs containing codeine. Codelac, like many other opium alkaloid-based products, has disappeared from pharmacy shelves.

The consumption of codeine in large quantities entails euphoria and leads to the development of addiction. However, the license for the drug is currently valid.

Pills

A complex action tool in . According to the instructions for use, the tablets are round, yellow or brownish in color. The presence of inclusions is allowed in the structure.

For children, Codelac containing codeine is prohibited until children reach the age of 2 years.

Syrup

The drug is recommended for the symptomatic treatment of dry cough. It is a thick brownish liquid with a sweet taste. Due to the opium alkaloid included in the composition, it can enhance the effect of painkillers, sedatives and hypnotics. Children under 3 years of age are prohibited from prescribing. The dosage and duration of treatment are indicated in the instructions for use.

In the annotation it is called a phytoelixir. Manufactured using the same active ingredients as the above forms of Codelac. The active substance that distinguishes the composition of the phytoelixir is thyme extract. The herbal extract produces an expectorant effect, relieves inflammation, and is a local anesthetic.

Codelac Neo with butamirate antitussive

A line of drugs is recommended to get rid of dry cough. Codelac for children and adults of the Neo series is available in various dosage forms. According to the instructions for use, the listed funds are not allowed to be combined with mucolytics.

Recommended for whooping cough, with. Codelac tablets should not be taken before the age of 18. The tool is distinguished by an innovative formula that accelerates the release of butamirate. According to the instructions for use, twice a day is enough for a therapeutic effect.

Convenient liquid form suitable for children and their parents. Sold in dark glass bottles 100/200 ml. The advantage is the vanilla taste and aroma of Codelac syrup. For children, cough is recommended to use this particular form. However, up to 3 years, drinking the drug is prohibited.

Drops

Designed for the smallest patients, but also suitable for therapy in adults. According to the instructions for use, they are prescribed for children from 2 months. Before use in babies under 2 years old, it is recommended to discuss Codelac drops with a pediatrician. Side effects and possible limitations do not always allow us to call the remedy the drug of choice for infants.

For babies and older children, both drops and syrup are recommended. According to the instructions for use, only the tablet form is prohibited. The tool begins to act within 15-30 minutes after administration. The effect persists for 12 hours.

A wet, or productive, cough is a symptom accompanied by the separation of a viscous tracheobronchial secret. Suppression of the antitussive center in the productive form leads to the development of complications.

That is why a special Codelac for wet cough for children and adults has been developed for symptomatic therapy. It is necessary to use the product according to the instructions for use.

thyme syrup

The composition of the drug does not contain ethanol, sugar and artificial colors. The liquid form and pleasant taste make it easy to use Codelac in children. For the convenience of portioning the syrup, each bottle is equipped with a special measuring spoon.

They are flat, round tablets that have a yellowish or brownish tint with dark patches. You should not recommend Codelac tablets for children. Instructions for use allow you to take the drug only from the age of 12.

Instructions for taking medicines

Before the first reception it is necessary to study the instruction Codelac. The method of application differs from the type of drug, its dosage form and the individual characteristics of the patient.

Indications

Table 3. Types of Codelac, indications for the use of the drug

NameIndications
With codeinePathologies accompanied by dry cough and caused by various reasons. It is used for the treatment of infectious and inflammatory diseases, allergies, etc.
NeoIt is important to understand what kind of cough Codelac Neo is. This form is used for therapy with a dry type. The product is recommended for children and adults with whooping cough, as well as before / after surgery and before bronchoscopy
bronchoAccording to the instructions for use, it is prescribed for diseases of various etiologies to get rid of a productive cough. Among the probable diagnoses: SARS, etc.

Mode of application

Each dosage form implies following certain rules in the treatment process. All of them are listed in the instructions for use.

Table 4 Use in children and adults

NameForm of the drugWay
With codeinePillsRegardless of the meal, drinking water. Any form of codeine should not be combined with centrally acting analgesics.
Syrup60 minutes after eating
PhytoelixirBetween meals
NeoSyrupInside before meals
PillsAccording to the instructions for use, drink before eating, without chewing.
DropsBefore eating
bronchoElixirTogether with food, washing down with a small amount of water
PillsDuring a meal

Dosages

Table 5. The amount of the drug needed to treat children and adults

NameForm of the drugDosage
With codeinePills1* 2-3 times / day.
SyrupFor a day for children 2-5 years old - 5 ml;

from 12 and adults - 15-20.
PhytoelixirFor a day for children 2-5 years old - 5 ml;
5-8 years - 10; 8-12 - 10-15 ml;
from 12 and adults - 15-20.
The indicated amount is divided into 3 doses
NeoSyrup3-6 years - 5 ml * 3 times / day.
6-12 years - 10 ml * 3 times / day.
For children from 12 years old and adults - 15 ml * 4 times / day.
Pills1 every 8-12 hours
DropsToddlers 2-12 months. - 10cap. *4 times/day;
1-3 years - 15cap. *4 times/day;
older - 25cap. *4 times/day.
bronchoElixir2-6 years - 2.5 ml * 3 times / day.
6-12 years - 5 ml * 3 times / day.
For children from 12 years old and adults - 10 ml * 4 times / day.
Pills1*3 times/day
If there is no effect within 3-6 days, it is necessary to stop treatment with this remedy.

Possible side effects

Despite the fact that the drug is safe, its use can cause negative reactions of the body.

Table 6. Possible side effects of Codelac

Probability of overdose

Excessive consumption of the drug adversely affects the body.

Table 7. Codelac overdose and its consequences

Overview of reviews

There are many opinions about Codelac. Reviews describe both the pros and cons of the tool.

Table 8. Overview of drug opinions

NameprosMinuses
With codeineFast acting, long lasting effect, convenient dosage regimenIt is impossible to purchase Codelac - a prescription is required. The composition contains an opium derivative, can cause side effects and has contraindications. Is a drug
NeoVariety of dosage forms, availability in pharmacies, high efficiency, long-term effectLess effective than codeine. Inconvenient measuring spoon for syrup, unpleasant aftertaste, not always effective, causes allergies
bronchoQuickly relieves cough, has a pleasant taste, available in pharmaciesAddictive
You should not rely on reviews when choosing a remedy. Codelac for children and adults is effective only if the type of cough is correctly identified.

Analogues

Analogues are drugs that have an identical active substance in the composition and have a similar effect.

Table 9. Codelac analogs of various types

Substitutes are cheaper

Perhaps without spending extra money on Codelac. Analogues cheaper are widely represented in pharmacies.

Table 10. How to replace the drug

To choose a remedy, it is worth studying the composition in Latin. Codelac and substitute must have the same active ingredients. However, you can buy a drug-synonymous.

Which is better - Codelac or Sinekod?

Sinekod is an analogue of only one of the listed means. It can only be compared with Neo. In other cases, it is impossible to say which is better - Codelac or Sinekod. Sinekod can be used for therapy with a wet cough, but only in consultation with the doctor.

Useful video

Useful information about the treatment of bronchitis can be found in this video:

conclusions

  1. The high efficiency of the drug allows us to recommend it for both adults and children.
  2. Codelac, instructions for use of which are contained in each package, is used for the treatment of dry and wet cough.
  3. The key point in the treatment is the appointment of funds in accordance with the indications.

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