Betadine vaginal suppositories - instructions for use. Betadine solution Betadine iodine solution

100 ml solution contains

active substance- povidone-iodine 10 g (corresponding to active iodine 0.9 - 1.2 g),

Excipients: glycerin 85%, nonoxynol 9, anhydrous citric acid, disodium hydrogen phosphate anhydrate, sodium hydroxide (10% solution (m / o) for pH adjustment), purified water.

Description

The solution is dark brown in color, with the smell of iodine, not containing suspended or precipitated particles.

Pharmacotherapeutic group

Antiseptics and disinfectants. Iodine preparations. Povidone-Iodine

ATX code D08AG02

Pharmacological properties

Pharmacokinetics

In healthy people, the absorption of iodine with topical application of the drug is insignificant. The absorption of povidone and its excretion by the kidneys depends on the average molecular weight (mixture). For substances with a molecular weight above 35000-50000, a delay in the body is possible. With intravaginal application, the fate of absorbed iodine or iodide in the body is basically the same as the fate of iodine administered in any other way. The biological half-life is approximately 2 days. Iodine is excreted almost exclusively by the kidneys.

Pharmacodynamics

Povidone-iodine is a complex of a polymer of polyvinylpyrrolidone (povidone) with iodine. After application to the surface of the skin, iodine is released from this complex for some time. It has long been known that elemental iodine (I2) is a highly effective microbicidal substance capable of in vitro quickly destroy bacteria, viruses, fungi and some protozoa using two mechanisms: free iodine quickly kills microorganisms, and the PVP-iodine complex is a depot of iodine. Upon contact with the skin and mucous membranes, an increasing amount of iodine dissociates from the complex with the polymer.

Free iodine reacts with oxidizable groups of SH- or OH- amino acid units of enzymes and structural proteins of microorganisms, inactivating and destroying these enzymes and proteins. In conditions in vitro most vegetative microorganisms are destroyed in 15-30 seconds. At the same time, iodine becomes discolored, and therefore the intensity of brown staining serves as an indicator of the effectiveness of the drug. After discoloration, it is possible to re-apply the drug. There have been no reports of the development of resistance.

Indications for use

Skin disinfection before biopsy, injections, punctures, blood sampling and transfusion, infusion therapy

Antiseptic treatment of the skin and mucous membranes, e.g. before surgery, gynecological and obstetric procedures

Aseptic wound care

Bacterial and fungal skin infections

Complete or partial preoperative skin disinfection (preoperative disinfectant preparation of the patient, “disinfectant baths”)

Dosage and administration

Betadine solution is intended for topical external use.

Do not pour Betadine solution into hot water.

Do not heat the solution before use.

The solution should be prepared immediately before use and used as soon as possible.

Betadine solution can be used undiluted or diluted with water as a 10% (1:10) or 1% (1:100) solution, depending on the area to be disinfected.

The drug should be left on the skin for 1-2 minutes before injection, blood sampling, biopsy, blood transfusion, infusion therapy or before any other surgical intervention on intact skin.

For aseptic treatment of wounds, burns, for disinfection of mucous membranes, for bacterial and fungal infections of the skin, a 10% solution is used (dissolving Betadine with water in a ratio of 1:10).

For preoperative "disinfectant baths" a 1% solution of Betadine (1:100) is used. The entire surface of the body should be evenly treated with a 1% solution of Betadine and, after a 2-minute exposure, wash off the solution with warm water.

Betadine solution should be diluted immediately before use. The prepared solution cannot be stored.

Betadine solution is easily removed with warm water. Stubborn stains should be treated with sodium thiosulfate solution.

During preoperative disinfection of the skin, it is necessary to ensure that excess solution does not accumulate under the patient. Prolonged contact with the solution may cause skin irritation and, in rare cases, severe skin reactions. The accumulation of the solution under the patient can cause a chemical burn.

Side effects

Rare (≥1/10,000 -<1/1,000)

Hypersensitivity

Contact dermatitis (with symptoms such as erythema, small blisters on the skin, itching)

Very rarely

Anaphylactic reaction

Hyperthyroidism (sometimes accompanied by symptoms such as tachycardia and restlessness). In patients with a history of thyroid disease after the use of povidone-iodine in large quantities (for example, after prolonged use of a solution of povidone-iodine to treat wounds and burns on a large surface of the skin)

Angioedema

Frequency not known (cannot be determined from the available data):

Hypothyroidism (after taking large amounts of povidone-iodine or after long-term use)

Electrolyte disturbance (possibly after high doses of povidone-iodine (eg, in the treatment of burns))

Metabolic acidosis**

Pneumonitis (complication associated with aspiration)

Acute renal failure**

Change in blood osmolarity**

Chemical burn of the skin, may develop due to the accumulation of excess solution under the patient in preparation for surgery

** may develop after the use of povidone-iodine in significant amounts on large areas of the skin or mucous membranes (for example, in the treatment of burns)

Reports of suspected adverse reactions

The provision of data on suspected adverse drug reactions is very important to enable continuous monitoring of the risk/benefit ratio of the medicinal product. Health care professionals should be provided with information about any suspected adverse reactions through the contacts listed at the end of the instructions, as well as through the national information collection system.

Contraindications

Hypersensitivity to the active substance or other excipients

hyperthyroidism

Other acute thyroid diseases

Duhring's dermatitis herpetiformis

Condition before and after the use of radioactive iodine in the treatment of the thyroid gland.

Drug Interactions

The povidone-iodine complex is effective in the pH range of 2.0 - 7.0. Probably, the drug can react with proteins and other unsaturated organic complexes, which will lead to a deterioration in its effectiveness.

The combined use of Betadine and enzyme preparations for the treatment of wounds leads to a mutual decrease in effectiveness. Preparations containing mercury, silver, hydrogen peroxide and taurolidine may interact with povidone-iodine and should therefore not be used concomitantly.

The PVP-iodine complex is also incompatible with reducing agents, preparations containing alkali metal salts and substances capable of reacting with acids.

The use of povidone-iodine at the same time or immediately after the use of antiseptics containing octenidine on the same or adjacent areas of the skin can lead to the formation of dark spots on the treated surface.

The oxidative effect of povidone-iodine can lead to false-positive results in various diagnostic tests (for example, measurement of hemoglobin and glucose in feces and urine using toluidine and guaiac resins).

Absorption of iodine from a povidone-iodine solution may alter the results of thyroid function tests.

The use of PVP-iodine may reduce the uptake of iodine by the thyroid gland, which may affect the results of some tests and procedures (thyroid scintigraphy, determination of protein-bound iodine, diagnostic procedures using radioactive iodine), and therefore planning the treatment of thyroid diseases with iodine preparations may become impossible. After stopping the use of PVP-iodine, a certain period of time should be maintained before the next scintigraphy.

special instructions

During preoperative preparation of the patient, it is necessary to ensure that excess solution does not accumulate under the patient. Prolonged contact with the solution may cause skin irritation and, in rare cases, severe skin reactions. The accumulation of the solution under the patient can cause a chemical burn. In case of skin irritation, contact dermatitis or hypersensitivity, the drug should be discontinued.

The drug should not be heated before use.

Patients with goiter, thyroid nodules, and other non-acute thyroid disorders are at an increased risk of developing hyperthyroidism when given large amounts of iodine. In this group of patients, due to the lack of unambiguous indications, the use of povidone-iodine solution for a long time and on extensive skin surfaces is unacceptable. Such patients should be monitored for early signs of hyperthyroidism and, if necessary, monitor thyroid function, even after discontinuation of the drug.

Betadine should not be used before or after radioactive iodine scintigraphy or radioactive iodine treatment of thyroid carcinoma.

When using the oropharyngeal solution, avoid getting povidone-iodine into the respiratory tract, as this can cause pneumonitis. This is especially important in intubated patients.

The dark red color of the solution indicates its effectiveness. Discoloration of the solution indicates a deterioration in its antimicrobial properties. Degradation of the solution occurs in the light and at temperatures above 40°C. Avoid getting the drug in the eyes.

Application in pediatrics

Newborns and children at an early age are at increased risk of developing hypothyroidism with the use of large amounts of iodine. Since children of this age have increased sensitivity to iodine and increased skin permeability, the use of PVP iodine in children of this age group should be minimal. If necessary, thyroid function should be monitored (the level of hormones T4 and thyroid-stimulating hormone / TSH /). Any possible oral exposure to povidone-iodine in children should be strictly avoided.

Betadine is one of the popular antiseptics used in surgery, gynecology, pediatrics and other areas of medicine. At what age can you use this medicine in children and what features of the application is important for parents to know?

Release form

In the pharmacy assortment you can find such Betadine:

The solution used for external processing. This brown transparent liquid contains 10% of the active substance. The solution is poured into polyethylene bottles of different volumes - 30 ml, 120 ml and 1000 ml.
Ointment for external use. It is represented by a homogeneous mass of brown color, which has an unexpressed smell of iodine. One tube contains 20 g of ointment with a 10% content of the active ingredient.
Vaginal suppositories. They are distinguished by dark brown color, elongated shape and homogeneous structure. One package contains 7 or 14 suppositories.

Compound

The main ingredient in any form of Betadine is called povidone-iodine. In 1 ml of solution and 1 gram of ointment, it is contained in a dose of 100 mg. In one suppository, such a substance is contained in an amount of 200 mg.
Water, glycerol, Na hydroxide solution and disodium hydrogen phosphate are added to the liquid form. In addition, citric acid and nonoxynol 9 act as auxiliary components of the solution.
In Betadine ointment, in addition to povidone-iodine, purified water and Na bicarbonate, 4 types of macrogol (400, 1000, 1500 and 4000) are added.
In candles, macrogol 1000 is an additional component.

Operating principle

Betadine is classified as an antiseptic used topically and externally. Iodine, which is released from such a drug upon contact with the mucous membrane or skin surface, combines with microbial proteins, causing the bacteria to die within 15-60 seconds after treatment.

The drug has a bactericidal effect against many gram-positive and gram-negative microorganisms. Also, the tool affects fungi, protozoa and viruses. Only tuberculosis mycobacteria are resistant to it.

The principles of action of Betadine are very well shown in this video:

Indications

Betadine in solution is used for various purposes:

This preparation is used to treat the patient's skin during surgical treatment - both before the operation and after the intervention.
Betadine is used in various medical procedures, such as injections, punctures, or biopsies. Lubricate the skin around the probe, catheter or drainage with this solution.
Surgeons and other medical professionals apply this medicine to their hands before various procedures.
Betadine is advised to treat the hands of people who care for an infected patient.
Such a drug is also in demand for the processing of patient care items.
The agent is used topically for infection of the nasopharynx (drip into the nose), as well as the oral cavity (the mucosa is treated with stomatitis, used for gargling).
Betadine is successfully used for various skin infections. It helps with viral lesions (for example, with chickenpox), with a fungal infection and purulent skin lesions.
Treatment with Betadine is prescribed for trophic ulcers, as well as for bedsores.

Betadine in the form of an ointment is in demand for purulent dermatitis, wounds, burns, trophic ulcers and other skin problems.

Betadine suppositories are prescribed for vaginosis, candidiasis, vaginitis and trichomonas infection, as well as for diagnostic or surgical procedures in the vagina.

At what age is it allowed to take?

Instructions for use of the ointment or solution prohibit the treatment with Betadine in children during the neonatal period.

The use of the drug in the first 4 weeks of life is permissible only if absolutely necessary and only after tests that determine the state of the thyroid gland.

For children older than a month, such forms of medicine can be used without fear, and in candles it is prescribed for girls over 8 years old.

Contraindications

Treatment with Betadine is prohibited:

With renal failure.
With thyroid adenoma.
With hypersensitivity to iodine.
With hyperthyroidism.
With dermatitis herpetiformis.

Side effects

If the patient has an increased sensitivity to iodine, treatment with Betadine will cause him to flush, itching and other local symptoms, after which the drug should be immediately discontinued. To make sure that there is no iodine intolerance, the first use of the drug should be trial - in a small amount on a small area of \u200b\u200bthe skin.

If Betadine is used in large quantities, treating a large area of the skin or mucous membrane, iodine from the drug will be absorbed, which can worsen thyroid function. The same side effect can be observed with a very long use of the drug.

Instructions for use and dosage

Liquid Betadine is used according to the following recommendations:

To treat the skin with Betadine solution, it is not required to dilute it. For the treatment of mucous membranes, drains, burn surfaces and in some other cases, the drug is diluted to a concentration of 0.1% to 5%.
Liquid Betadine must not be heated.
The medicine should not get into the eyes.
If Betadine comes into contact with blood when treating wounds, this will reduce its bactericidal effect.
The drug should not be used for animal or insect bites.
The surface treated with Betadine turns brown due to the formation of a film from which iodine is released. When it disappears, the effect of the drug ends. If necessary, such a film can be easily removed with water.

Ointment Betadine gently lubricate the damaged skin. This dosage form is applied in a thin layer 2 to 3 times during the day. If required, the treated surface can be covered with an occlusive dressing. The ointment should not get on the mucous membrane of the eye, and the skin after lubrication, as in the case of treatment with a solution, acquires a brown tint, which can be easily eliminated by washing with plain water.

The Betadine suppository should be moistened with water and carefully inserted into the vagina (this form is especially carefully used in virgins). The medicine is used at night for 7-14 days.

Overdose

With very severe poisoning, laryngeal edema, deterioration of kidney function and blood circulation, as well as pulmonary edema, are possible. For treatment, the doctor prescribes symptomatic therapy.

Interaction with other drugs

Liquid Betadine should not be mixed with any disinfectant and antiseptic preparations, especially if they contain enzymes, mercury or alkali. The same restriction is provided for the ointment.

Terms of sale

The purchase of any form of the drug in a pharmacy is available without a prescription. The average price of 30 ml of solution is 160-170 rubles, tubes of ointment - 240-250 rubles, and packages of 7 suppositories - 350-400 rubles.

Storage conditions and shelf life

For storage, choose an unlit, dry place where a small child does not have access. The liquid form should be stored at room temperature (below + 30 ° C), the optimal temperature range for storing the ointment is + 15 + 25 ° C, and for storing candles - + 5 + 15 ° C. The shelf life of the solution and ointment is 3 years, for suppositories - 5 years.

Betadine is an antiseptic and disinfectant drug for local and external use.

Being released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms.

On this page you will find all the information about Betadine: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Betadine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiseptic.

Terms of dispensing from pharmacies

Released without a prescription.

Prices

How much does Betadine cost? The average price in pharmacies is at the level of 450 rubles for candles, the ointment costs 250 rubles, and the solution can be bought for 300 rubles.

Release form and composition

Betadine is available in the following dosage forms:

10% ointment for external use in aluminum tubes of 20 g, one tube in a cardboard box. 1 g of Betadine ointment contains 100 mg of povidone-iodine and auxiliary components (macrogol - 400, 1000 and 4000, sodium bicarbonate and purified water);
10% solution for local and external use in dropper bottles of 30 and 120 ml (in cardboard boxes) or 1000 ml (without box). The main active ingredient of the drug is povidone-iodine (100 mg in 1 ml of solution), and the auxiliary ones are glycerin, anhydrous citric acid, nonoxynol 9, sodium hydroxide 10%, disodium dihydrogen phosphate and purified water;
Vaginal suppositories dark brown torpedo-shaped. One suppository contains 200 mg of povidone-iodine and macrogol 1000 as an excipient. Candles are packed in blisters of 7 pieces, in a cardboard bundle 1 or 2 blisters.

Pharmacological effect

The drug is a complex compound of iodine and polyvinylpyrrolidone (PVP). PVP, an inert synthetic polymer, acts as a carrier. Accordingly, all the pharmacological properties of the drug are associated only with iodine, which belongs to the group of halogen antiseptics; The spectrum of action of iodine extends to Gram-positive and Gram-negative bacteria, fungi, protozoa, treponemas, viruses and acid-fast bacteria.

The bactericidal effect of iodine is explained by its strong oxidizing properties, it actively interacts with the amino acids of proteins, as a result of which the quaternary structure of the protein changes, its catalytic and enzymatic activity is lost. Basically, iodine disrupts the structures of bacterial transmembrane proteins and enzymes that do not have membrane protection. The concentration of active iodine in Betadine is 0.1-1%. Suppositories are made on a water-soluble basis and do not irritate the mucous membrane. When applied topically, there is almost no resorption of iodine from the mucous membrane.

Indications for use

Candles Betadine is used in the following cases:

(as part of combination therapy);
fungal infections of the vagina resulting from treatment with steroid and antibacterial drugs;
chronic and acute infections of the vagina of a specific and non-specific nature (vaginitis, bacterial, etc.);
treatment before and after transvaginal interventions during obstetric and diagnostic procedures.

Ointment Betadine has the following indications:

treatment of bacterial and fungal skin infections;
treatment of bedsores infected;
prevention of injury or infection of the skin (with small cuts and abrasions, minor burns and surgical interventions).

According to the instructions, Betadine solution is used in the following cases:

for disinfection of wounds and burns;
as first aid for contamination of mucous membranes or skin with infected material;
for antiseptic treatment of the operating room before gynecological, obstetric and surgical procedures and operations;
for disinfection of hands before taking a biopsy, performing punctures, injections, catheterization of the bladder.

Contraindications

The use of this remedy is contraindicated in such diseases and conditions:

subject to the simultaneous use of radioactive iodine;
at the age of a child under 1 year;
hyperthyroidism;
dermatitis herpetiformis Dühring;
thyroid adenoma;
with high sensitivity to iodine, as well as to other components of this remedy.

The use of the drug for newborns and premature babies is contraindicated. It is carefully used for chronic inflammation of the skin, during pregnancy, as well as during lactation.

Instructions for candles

At acute vaginitis appoint 1 suppository 1-2 times / day for 7 days.
At chronic and subacute vaginitis- 1 suppository 1 time / day at bedtime for 14 days, if necessary - longer.

Instructions for ointment

Apply only externally. On the affected surface of the skin, the ointment is applied in a thin layer 2-3 times / day. Can be used under occlusive dressings.

Instructions for the solution

For the treatment of the skin and mucous membranes, the Betadine solution is used undiluted for lubrication, washing, or as a wet compress.

For use in drainage systems, a 10% solution is diluted 10 to 100 times. The solution is prepared immediately before use, diluted solutions are not stored.

Side effects

The following side effects of suppositories and other forms of release of the drug are noted:

local manifestations of an allergic reaction to iodine in the form of redness, rash, itching;
vaginal dysbacteriosis (with prolonged use of suppositories);
thyrotoxicosis (with a hereditary predisposition).

Overdose

In case of an overdose, the following symptoms may be observed:

Dermatitis and redness of the skin.
Diarrhea.
Impaired renal function.
Intestinal disorders.
Metallic taste in the mouth.
Eye irritation and swelling.
Burning in mouth and throat.
Pulmonary swelling.
Hypernatremia.

special instructions

The use of Betadine may reduce the uptake of iodine by the thyroid gland and distort the results of diagnostic studies (thyroid scintigraphy, determination of protein-bound iodine, measurements using radioactive iodine) or interfere with iodine therapy of the thyroid gland. After using the drug Betadine before carrying out the listed procedures, a period should be maintained, the duration of which should be determined by the doctor.
Prolonged use of Betadine can lead to absorption through the skin and mucous membranes of a significant amount of iodine. Therefore, after prolonged use of suppositories, it is necessary to perform a study of thyroid function.
The use of Betadine suppositories in children before puberty is contraindicated. The doctor should decide on the possibility of using the drug in virgins and at least the first administration of the suppository.
Contamination with povidone-iodine can cause false-positive results in some diagnostic tests, such as fecal occult blood or urine glucose.
Accidental ingestion of suppositories by children should be avoided.

drug interaction

It is forbidden to use Betadine vaginal suppositories together with other antiseptics: alcohol, salicylic acid, hydrogen peroxide, etc. So the risk of getting a burn on the membranes of the genital organs increases significantly, the effectiveness of the use of both drugs decreases. The complex use of suppositories with preparations that contain taurolidine, silver, mercury, lithium and enzymes is unacceptable.

Content

There is a wide range of medicines that have a disinfecting effect. These include Betadine solution - an antiseptic that is used by gynecologists, surgeons and other doctors, the drug is successfully used for the treatment and prevention of many diseases. The main component of Betadine is iodine, so the product has a very wide spectrum of action aimed at combating bacteria, fungi and similar harmful organisms. According to reviews, the drug is distinguished by low toxicity, safety and high efficacy of the drug.

Betadine solution - instructions for use

A special topical solution with an antiseptic effect is Betadine. This medication combines iodine and polyvinylpyrrolidone, which binds it. The drug is also called povidone-iodine (generic international name). It has antiviral, disinfectant, disinfecting, bactericidal action.

Composition and form of release

Antiseptic medication is available in polyethylene bottles of 30, 120, 1000 ml. The kit includes a special dropper and a screw-on propylene stopper with first opening control. A container with a preparation of 30 and 120 ml is packed in a pack of cardboard, inside there is an instruction for the use of the medicine. The 1000 ml bottle is not packaged in a separate package, an annotation plus two labels is simply attached to it. Betadine solution is a dark brown liquid with the smell of iodine.

Due to the composition of Betadine, the maximum therapeutic effect is achieved. The tool contains the following active and additional components:

Substance	Quantity (per 100 ml of product)
Active element povidone-iodine
Disodium hydrogen phosphate
Nonoxynol 9
Anhydrous citric acid
Glycerol
Sodium hydroxide solution	10% solution (w/v) for pH adjustment
Purified water	Remaining volume

The mechanism of action of the drug

The disinfecting effect of the use of the drug Betadine is achieved with the help of iodine, which is released from the complex with polyvinylpyrrolidone. This occurs during the process of contact with the mucous membranes and human skin. Bottom line: the active element interacts with oxidizable groups of amino acids that are part of the structure of enzymes of microorganisms and proteins. The effect of the drug: the destruction of gram-positive, gram-negative microbes, some viruses, protozoa, spores and fungi.

After a long course of treatment of wounds, burns on large areas of the skin, an increased content of iodine is observed in the body. The values decrease to normal one to two weeks after the last use of povidone-iodine. It is excreted exclusively through the kidneys. In patients with a healthy thyroid gland, an increase in the level of the active substance does not affect the hormonal background.

Indications for use

A drug antiseptic is sold without a prescription, but it can be taken only according to indications. Otherwise, you can aggravate the disease and worsen the state of health in general. The main pathologies for which Betadine is prescribed:

bedsores;
disinfection of the skin with microdamages, ulcers;
diabetic foot;
domestic burns, wounds;
antiseptic burns in traumatology and surgery;
bactericidal activity;
trophic ulcers;
disinfection of the skin area in which the catheter, probe or drainage system is installed;
therapy of bacterial, fungal, viral skin infections;
disinfection of the oral cavity in the presence of stomatitis and similar infections, during a dental operation;
Betadine solution is used in dermatology to avoid the development of a severe form of infection;
gynecology: treatment of mucous membranes before minor surgery (abortion, removal of erosion and polyps, insertion of an IUD);
obstetrics: antiseptics of the birth canal of a woman;
venereology: trichomoniasis, mycosis;
disinfection of parts of the mucous membranes, skin in the process of preparing for surgery or installing a dropper.

Betadine throat gargle

The drug is considered effective in infectious and viral infections that affect the throat, oral cavity of a person. For rinsing, an aqueous solution of iodine is used (ratio 1:10). Often, Betadine is used to treat such diseases:

angina (tonsillitis);
pharyngitis;
laryngitis, etc.

Betadine for burns

The drug for external use has a disinfecting effect on the following skin lesions:

Treatment of small burns (solution 10%).
Antiseptic for burn wounds.
Therapy of the skin damaged by fire is carried out with 1%, 5% or 10% povidone-iodine, which depends on the severity of the wounds.

In the process of treatment, you need to be as careful as possible, since the antiseptic treatment of large areas of severely damaged skin can lead to certain consequences:

negative reactions from the exchange of electrolytes (increase in the amount of sodium in the blood serum);
changes in osmolarity;
metabolic acidosis;
disorders in the work of the kidneys.

Treatment of wounds

By means of the drug Betadine, wounds of various kinds on the skin are often treated:

bedsores;
abrasions, scratches;
cut wounds;
treatment of skin with ulcers;
superficial dermatoses;
prevention of infection in wound surfaces.

Method of application and dosage

According to the instructions, the medicine can be used concentrated or mixed with water (do not dilute hot). When treating burns, wounds, preparing for surgery, the drug is diluted with isotonic sodium chloride solution. You can warm the medicine in your hands to room temperature. The tool is used no more than two or three times a day. Features of using Betadine:

Antisepsis of minor wounds, abrasions, scratches, small burns: 10% povidone-iodine undiluted twice a day.
Disinfection of the mucosa and skin surface before surgery: undiluted preparation twice in a couple of minutes.
Bactericidal effect against wounds, treatment of their complications: pure or 5% agent 2-3 times a day.
Acne, abscesses on the skin should be treated with a cotton swab dipped in concentrated 5% or 10% povidone-iodine (1 part of the drug and 2 parts of water).
Burns are treated with 1%, 5% or 10% preparation (1 part of the active substance in 10 parts of water), depending on the severity of the damage.
According to doctors, for the treatment of fungal or bacterial dermatitis, the skin must be treated with a 1% solution.
Disinfection before medical procedures (biopsy, blood sampling, infusion, puncture) is carried out by means of a concentrate for two minutes.
The consequences of invasions (droppers) are eliminated with a 5% or 10% remedy.
Rinse the mouth, throat with a diluted solution twice a day.
Washing of serous and articular cavities is carried out once a day with 0.1% or 1% agent.
To disinfect the skin of newborns, a 0.1% solution is used, navel treatment - 10%, for the prevention of conjunctivitis in babies - 2 drops of 2.5-5% medication in each eye.
In transplantology, ophthalmology, 1% -5% medication is used.
Povidone-iodine is one-time used for hygienic disinfection of the birth canal, minor gynecological operations, surgical treatment of cysts of parenchymal organs.
Herpes, papilloma are treated with a concentrated remedy. Hygienic treatment is performed twice a day.
Before surgery, the patient's body is wiped with a sponge soaked in Betadine (0.1-0.05%). Dilution of the solution: part 10% of the drug 100 and 200 parts of water.

special instructions

There are a number of special instructions that are prescribed in the instructions for the drug. If they are not adhered to, then side effects and complications of the pathology that is being treated may occur. Warnings and tips for using an antiseptic:

If a person has problems with the functioning of the thyroid gland, then it is allowed to use the remedy only under the supervision of a specialist.
Regular use of povidone-iodine should be cautious when the patient is ill with chronic renal failure.
On the site of the skin or mucous membrane, after the preparation has dried, a colored film is formed. This colored layer persists until all active iodine has left the body. When the film disappears, the drug stops its action.
Do not decontaminate bites of domestic / wild animals, insects.
Areas of skin and tissues after treatment with Betadine have a dark brown color. Discoloration is easily achieved with plain soap and water. If the stains are poorly removed, then you can use an ammonia solution.
It is necessary to ensure that no excess solution remains under the bedridden patient, otherwise this will lead to severe skin irritation.
If a disinfectant is ingested, the stomach is washed with diluted sodium thiosulfate (5%).

drug interaction

To avoid unpleasant side effects and not worsen your health, you need to know about the interaction of povidone-iodine with other medicines. The instructions say the following:

Betadine is incompatible with preparations containing mercury. This increases the risk of formation of alkaline mercury iodide.
The disinfectant may react with unsaturated organic compounds and proteins. This effect is compensated by increasing the dosage of povidone-iodine.
Patients who are being treated with lithium preparations are advised to refrain from prolonged therapy with a solution, especially on large affected surfaces.
The interaction of iodine with hydrogen peroxide, enzyme medicines (containing tauloridine and silver) can cause a mutual decrease in the effectiveness of drugs.

Betadine for children

The disinfectant has a slightly different effect on the skin of an infant than on the skin of an adult patient. An aseptic preparation cannot be used to treat premature babies and newborns (especially in the first month of life). The use of the drug is allowed only on the recommendation of a physician, and in the most extreme cases, after an examination of the thyroid gland.

Side effects

If the antiseptic is used illiterately, then unpleasant consequences may occur. When recommendations from the instructions are ignored, the following side effects are observed:

allergies (possible skin irritation, burning, itching, swelling, hyperemia);
hyperthyroidism - a chronic thyroid disease, which is characterized by an increase in the concentration of hormones in the blood (with long-term treatment with povidone-iodine);
osmolarity of blood serum;
electrolyte imbalance;
kidney failure;
rarely, an acute generalized reaction with hypotension and asthma attacks occurs.

Contraindications

Betadine has a number of contraindications that should not be ignored. Otherwise, health problems cannot be avoided. Main restrictions:

thyroid adenoma;
lactation period, pregnancy (2nd and 3rd trimester);
hyperthyroidism;
hypersensitivity to active and additional elements of the drug;
Duhring's dermatitis herpetiformis.

Terms of sale and storage

Povidone-iodine is available in pharmacies without a prescription. The solution is stored in a dark, dry place at an air temperature of no more than 30 degrees above zero. The shelf life of the drug is 3 years.

Betadine analog

In pharmacy kiosks you can find an assortment of analogues of a disinfectant. The most popular and effective means are:

Povidone-Iodine;
Yodiksol;
Iodinol;
Octasept;
Iodoflex;
Betiod.

Price Betadine

You can buy a broad-spectrum antiseptic at any pharmacy in Moscow and the region. The cost of the drug depends on the manufacturer, the form of release and the specific place of sale. Below is a table with an average approximate price for a disinfectant in different pharmacies in the country.

Video

Antiseptics - halogens and halogenated.

Composition Betadine

The active substance is povidone-iodine.

Manufacturers

Egis Pharmaceutical Works SA (Hungary), Egis Pharmaceutical Plant (Hungary)

pharmachologic effect

Antiseptic, disinfectant.

It has a wide spectrum of antimicrobial activity (gram-positive and gram-negative bacteria - with the exception of M / tuberculosis, fungi, viruses, protozoa).

It has a longer effect than inorganic iodine solution.

Suppositories are made on a water-soluble basis and do not irritate.

When applied topically, there is practically no absorption of iodine from the skin, mucous membranes or wounds.

Side effects of Betadine

When applied to a large wound surface and mucous membranes, systemic reabsorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland, and also lead to the development of neutropenia.

In some cases, with hypersensitivity to the drug, local manifestations of allergic reactions to iodine (hyperemia, burning, itching, swelling, pain) may occur, requiring drug withdrawal.

Long-term use (more than 7-10 days) can cause the phenomenon of iodism ("metallic" taste in the mouth, increased salivation, swelling of the eyes or larynx, etc.), upon the appearance of which you should stop using the drug and consult a doctor.

Indications for use

Solution for external use 10%.

Treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry.

Treatment of bacterial, fungal and viral infections of the skin, prevention of superinfection in dermatological practice.

Treatment of bedsores, trophic ulcers, diabetic foot.

Disinfection of the skin and mucous membranes of patients in preparation for surgery, invasive studies (punctures, biopsies, injections, etc.) Disinfection of the skin around catheters, drains, probes.

Disinfection of the oral cavity during dental operations.

Disinfection of the birth canal during "small" gynecological operations (artificial termination of pregnancy, the introduction of an intrauterine device, coagulation of erosion or a polyp, etc.).

Solution 7.5% for external use foaming. "" Disinfectant bathing ", for the complete or partial treatment of patients before surgery.

Disinfection of the skin of the hands of surgical personnel.

Hygienic treatment of patients.

Hygiene treatment of hands in contact with infected patients.

Processing of non-metallic instruments and patient care items.

Concentrate for the preparation of a solution for topical use.

Inflammatory processes in the mouth and throat.

Condition after surgical interventions in the mouth and throat.

Eliminate bad breath.

Bacterial and fungal infections of the skin, burns, trophic ulcers, bedsores, infectious dermatitis, abrasions, wounds.

Vaginal suppositories.

Treatment of vaginitis (mixed, non-specific), candidiasis, trichomoniasis, genital herpes; preoperative preparation.

Contraindications Betadine

Hypersensitivity, thyroid adenoma, hyperthyroidism, Duhring's dermatitis herpetiformis, chronic renal failure, simultaneous use of radioactive iodine, pregnancy, lactation, children under 8 years of age.

Method of application and dosage

1 suppository 1-2 times a day; the duration of treatment is 7-14 days.

Overdose

No information.

Interaction

Incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury.

Activity decreases in an acidic environment.

special instructions

Solution 10%, foaming solution 7.5%.

It is necessary to ensure that no excess solution remains under the patient.

Should not be heated before use.

Concentrate 8.5% for the preparation of a solution for topical use.

It has a deodorizing effect - it destroys bad breath that occurs after eating, alcoholic beverages, tobacco.

Solutions 10, 7.5%; concentrate 8.5%; ointment 10%.

The presence of pus and blood can reduce the antimicrobial effect of the drug.

At the site of application, a colored film is formed, which persists until the entire amount of active iodine is released, which means the termination of the drug.

Do not use for insect bites, domestic or wild animals.

All dosage forms.

Coloring on skin and fabrics is easily washed off with water.

Avoid getting the drug in the eyes.