Regidron - Indications for use. Powder Regidron: what helps
It is well known that almost 70 - 80% of the human body consists of water. In fact, this common expression is not entirely true. The liquid medium that fills the human body is a kind of physiological solutions, consisting of various chemical compounds. Therefore, excessive loss of moisture brings with it dehydration and the loss of useful substances dissolved in the liquid, which are necessary to maintain the normal functioning of the human body.
For this reason, diseases accompanied by severe vomiting and prolonged diarrhea are extremely dangerous. Such ailments include infectious lesions (dysentery, cholera), inflammation of the large intestine (enterocolitis) and small intestine (enteritis), diseases of the gallbladder and pancreas, and toxicosis in pregnant women. As a rule, such diseases lead to a significant loss of fluid - dehydration.
An aqueous solution of Regidron powder not only replenishes the body's fluid loss, it effectively corrects the acid-base balance, therefore it is recommended as an additional therapeutic agent in the complex treatment of diarrhea caused by an infectious lesion, for example, with cholera.
Also, to prevent acid-base imbalance (acidosis), Regidron is prescribed to people with increased sweating, hot shop workers, and also with increased physical exertion. Everyone knows how much fluid an athlete loses during training sessions.
The main advantage of Regidron powder is the low content of sodium chloride, which prevents a person from oversaturating the body with salt. But a sufficient amount of potassium chloride contributes to the rapid restoration of this trace element in the blood. This is extremely important for the normal functioning of the heart muscle.
Of course, in any case, the doctor prescribes treatment. Preparation of the drug is not difficult. To do this, add a liter of boiled water to the contents of the sachet and cool the remedy. Then, after shaking the liquid, take it in small sips after each bout of diarrhea. To obtain the desired effect, it is recommended to drink approximately 10 ml / kg of body weight within an hour. With a decrease in dehydration, the dose of the drug taken is reduced to 5 ml / kg of body weight. The presence of severe vomiting also contributes to excessive fluid loss, therefore, after each vomiting attack, an additional 10 ml / kg of solution is required.
As a rule, the course of application of Regidron lasts no more than 3-4 days. If diarrhea ends earlier, treatment is stopped. During the period of treatment, you should avoid eating foods that are rich in simple carbohydrates and fats.
Do not consider the remedy Regidron absolutely safe. Indications for the use of this powder indicate that its overdose threatens with muscle and nerve strain, loss of strength, clouding of consciousness, and even respiratory arrest. A slight excess of the proposed dosage makes sense only if additional administration of the solution is confirmed on the basis of special laboratory tests.
The drug Regidron has contraindications, which include diseases such as intestinal obstruction, impaired renal function, type 1 and 2, excessive susceptibility to some of the ingredients included in this drug. In addition, before taking this drug, an additional medical consultation is required in the presence of chronic fatigue syndrome, slow speech, high body temperature, anuria, diarrhea with blood impurities and a duration exceeding 5 days.
It should be noted that the drug interaction of Regidron with other medicines has not been fully studied. Therefore, a preliminary consultation with a doctor is required. Such a warning is quite justified, although the drug is sold without a prescription in the network of pharmacies. Do not self-medicate. Take care of yourself!
Regidron is a fairly well-known pharmaceutical brand from the Finnish company Orion Corporation. This drug is designed to compensate for the lack of fluid in the body and rid it of toxins. Produced in the form of a powder for the preparation of a solution for oral administration. This powder dissolves well in water to form a clear solution with a salty-sweet aftertaste. The composition of rehydron includes four substances: sodium chloride and citrate, potassium chloride and dextrose (the sweetness of the rehydron solution is due precisely to the presence of the latter).
Restoring the balance of fluid and electrolytes and achieving a stable level of fluid volume is a key therapeutic "background" in many diseases, against which the recovery process is much faster. These goals can be achieved in two ways: either by intravenous administration of isotonic electrolyte solutions, or by enteral administration of the same solutions. For the first time, the idea of compensating fluid and electrolytes in patients arose in 1830 among domestic doctors from the Moscow Institute of Artificial Mineral Waters: in this way they treated cholera. However, it took another 120 years or so for the principle of rehydration to become widespread in the treatment of debilitating diarrhea caused by cholera. At the same time, along with the intravenous administration of replacement solutions, their oral administration began to be practiced. The use of enteral solutions was based on the ability of glucose (dextrose) to increase the absorption of sodium in the small intestine, and even against the background of secretory losses caused by the action of bacterial toxins. Regidron embodies a group of enteral preparations-correctors of water-electrolyte balance, shifted due to dehydration of the body. Compared to standard oral rehydration solutions recommended by the World Health Organization, rehydron has a slightly lower osmolality (content of osmotically active particles): solutions with reduced osmolality have been proven to be very effective in restoring the target level of fluid and electrolytes in the body.
The concentration of sodium in rehydron is also lower than that traditionally used in such preparations (the purpose of which is to reduce the risk of developing hypernatremia), and potassium, on the contrary, is higher: thus, it is possible to quickly restore its level.
To prepare a solution of rehydron, you need 1 liter of boiled and chilled water. You need exactly a liter of water, because. a smaller amount will increase the concentration of the solution, which can provoke hypernatremia. The finished solution should be used within 24 hours, while all this time it should be stored at a temperature of 2 ° to 8 ° C, i.e. in a refrigerator. The solution must be pristine: the addition of any other components may interfere with the effect of the drug. Before treatment, it is necessary to assess the overall weight loss and the degree of dehydration. In order to avoid severe dehydration, it is recommended to start taking the drug at the first sign of diarrhea. As a rule, rehydron is applied within 3-4 days. The end of treatment is indicated by the end of diarrhea. The tactics of taking rehydron for the purpose of rehydration is as follows: for the first 6-10 hours, a solution should be taken in amounts twice the weight loss due to diarrhea (i.e. if the patient has lost 400 g, 0.8 l of rehydron should be taken); no other liquid is required during this period. If diarrhea does not stop, then further administration of the drug is carried out according to a special scheme given in the instructions for use. Pronounced dehydration is corrected by intravenous administration of rehydration agents, after which the patient can be transferred to rehydron.
Pharmacology
Preparation for the correction of energy and electrolyte balance.
Restores water-electrolyte balance, disturbed by dehydration; corrects acidosis.
The osmolality of the Regidron solution is 260 mosm/l, pH is 8.2.
Compared to standard oral rehydration solutions recommended by WHO, the osmolality of Regidron is slightly lower (the effectiveness of solutions for rehydration with reduced osmolality is well proven), the sodium concentration is also lower (to prevent the development of hypernatremia), and the potassium content is higher (for faster restoration of potassium levels). ).
Pharmacokinetics
Data on the pharmacokinetics of the drug Regidron are not available.Release form
Powder for oral solution white, crystalline, soluble in water; the prepared solution is clear, colorless, odorless, with a salty-sweet taste.
Laminated aluminum foil bags (4) - cardboard packs.
Laminated aluminum foil bags (20) - cardboard packs.
Dosage
One sachet is dissolved in 1 liter of water, the prepared solution is taken orally. If there is no certainty that the water is potable, it must be boiled and cooled before preparing the solution. The prepared solution should be stored in a cool place at a temperature of 2 ° to 8 ° C and used within 24 hours. Do not add any other components to the solution so as not to disrupt the effect of the drug.
Before starting treatment, the patient should be weighed to assess weight loss and degree of dehydration.
Patient nutrition or breastfeeding should not be interrupted during oral rehydration therapy or should be continued immediately after rehydration. It is recommended to avoid foods rich in fats and simple carbohydrates.
To prevent dehydration, Regidron should be taken as soon as diarrhea begins. Usually the drug is used for no more than 3-4 days, treatment is stopped with the end of diarrhea.
In case of nausea or vomiting, it is advisable to give the solution chilled in small repeated doses. You can also use a nasogastric tube under medical supervision.
For rehydration, Regidron is taken during the first 6-10 hours in an amount that is twice the weight loss caused by diarrhea. For example, if the body weight loss is 400 g, the amount of Regidron is 800 g or 8.0 dl. During this phase of treatment, the use of other fluids is not required.
If diarrhea continues after correction of dehydration, it is recommended to administer Regidron, water and other liquids within 24 hours according to the following scheme:
| Body weight (kg) | Total Fluid Required (dl) | Regidron (dl) | Water (dl) | Other fluids (dl) |
| 5 | 8.3 | 3.5 | 2.1 | 2.7 |
| 6 | 10.0 | 4.2 | 2.5 | 3.3 |
| 7 | 10.5 | 4.4 | 2.6 | 3.5 |
| 8 | 11.0 | 4.6 | 2.8 | 3.6 |
| 9 | 11.5 | 4.8 | 2.9 | 3.8 |
| 10 | 12.0 | 5.0 | 3.0 | 4.0 |
| 12 | 13.0 | 5.4 | 3.2 | 4.4 |
| 14 | 14.0 | 5.8 | 3.5 | 4.7 |
| 16 | 15.0 | 6.2 | 3.7 | 5.1 |
| 18 | 16.0 | 6.6 | 4.0 | 5.4 |
| 20 | 17.0 | 7.0 | 4.2 | 5.8 |
| 25 | 18.0 | 7.5 | 4.5 | 6.0 |
| 30 | 19.0 | 8.0 | 4.8 | 6.2 |
| 40 | 21.0 | 9.0 | 5.4 | 6.6 |
| 50 | 23.0 | 10.0 | 6.0 | 7.0 |
| 70 | 27.0 | 12.0 | 7.2 | 7.8 |
Overdose
Symptoms: with the introduction of a solution of Regidron in a large volume or excessive concentration, hypernatremia is possible (weakness, neuromuscular excitation, drowsiness, confusion, coma, sometimes even respiratory arrest); in patients with impaired renal function, metabolic alkalosis may develop, which manifests itself in a decrease in lung ventilation, neuromuscular excitation and tetanic convulsions.
Treatment: in case of significant overdose, medical supervision is required. Correction of the balance of electrolytes and fluids should be carried out on the basis of laboratory data.
Interaction
The drug interaction of the drug Regidron has not been studied.
The solution of the drug has a slightly alkaline reaction, therefore, it can affect the effectiveness of drugs, the absorption of which depends on the pH of the intestinal contents.
Diarrhea itself can alter the absorption of many drugs that are absorbed in the small or large intestine, or drugs that are metabolized through intrahepatic circulation.
Side effects
Indications
- restoration of water and electrolyte balance, correction of acidosis in acute diarrhea (including cholera), with thermal injuries associated with impaired water and electrolyte metabolism; for the purpose of prevention - thermal and physical activity, leading to intense sweating;
- oral rehydration therapy for acute diarrhea with mild (weight loss 3-5%) or moderate (weight loss 6-10%) degree of dehydration.
Contraindications
- impaired renal function;
- insulin-dependent diabetes mellitus;
- non-insulin dependent diabetes mellitus;
- unconscious state;
- intestinal obstruction;
- hypersensitivity to the components of the drug.
Application features
Use during pregnancy and lactation
In recommended doses, Regidron can be prescribed during pregnancy and lactation.Application for violations of kidney function
The drug is contraindicated in violations of kidney function.special instructions
Severe dehydration (weight loss >10%, anuria) should be corrected with intravenous rehydration agents, after which Regidron can be prescribed.
A packet of Regidron is dissolved in 1 liter of water. If a too concentrated solution is given in the recommended volume, the patient may develop hypernatremia.
Do not add sugar to the solution. Food can be given immediately after rehydration. In case of vomiting, wait 10 minutes and give the solution to drink slowly, in small sips. Patients who develop dehydration on the background of renal failure, diabetes mellitus or other chronic diseases in which acid-base, electrolyte or carbohydrate balance are disturbed require careful monitoring during treatment with Regidron.
When using the drug Regidron, a doctor's consultation is required in the following cases: slowing down of speech, rapid fatigue, drowsiness, the patient does not answer questions, an increase in body temperature over 39 ° C, cessation of urine output, the appearance of loose bloody stools, diarrhea lasting more than 5 days, sudden cessation diarrhea and the appearance of severe pain if home treatment is ineffective and impossible.
Influence on the ability to drive vehicles and control mechanisms
Regidron does not affect the ability to drive vehicles and control mechanisms.
Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.
Regidron: instructions for use
Compound
active substance: 1 sachet contains 2.5 g potassium chloride, 3.5 g sodium chloride, 2.9 g sodium citrate, 10 g anhydrous glucose;
pharmachologic effect
Pharmacotherapeutic group. Preparations of electrolytes with carbohydrates. Salt formulations for oral rehydration. pharmacological properties. Regidron solution is used to correct the loss of electrolytes and fluid during diarrhea and vomiting. Glucose promotes the absorption of salts and citrates, which helps to balance the acid-base balance of the blood. The osmolarity of the Regidron solution is 260 mosm/l, the pH is slightly alkaline - 8.2.
Compared to standard oral rehydration solutions recommended by WHO, the osmolarity of Regidron is slightly lower (the effectiveness of solutions for rehydration with reduced osmolarity is well proven), the sodium concentration is slightly lower (to prevent the development of hypernatremia), and the potassium content is higher (for faster restoration of potassium levels). ).
Pharmacokinetics
The pharmacokinetics of water, electrolytes and glucose, which are part of Regidron, correspond to the natural pharmacokinetics of these substances in the body.
Indications for use
Restoration of water and electrolyte balance, correction of acidosis in acute diarrhea (including cholera), diarrhea with mild (weight loss is 3-5%) or moderate (weight loss 6-10%) degree of dehydration, with thermal injuries associated with impaired water electrolyte exchange. For preventive purposes: heat and exercise, leading to intense sweating.
Contraindications
Hyperkalemia, renal failure, diabetes mellitus, severe forms of hypertension. Interaction with drugs. During treatment with Regidron, drugs should not be taken, the absorption of which depends on the pH of the intestinal contents.
The solution of the drug has a slightly alkaline reaction, therefore, it can affect drugs, the absorption of which depends on the pH of the intestinal contents.
Dosage and administration
The drug Regidron, a dosed powder, is intended for the preparation of a solution for oral administration.
Powder of 1 sachet is dissolved in 1 liter of boiled water. The finished solution is cooled to room temperature and stirred again before use.
The prepared solution should be taken after each liquid stool, in small sips at the dose recommended by the doctor. For 4-10 hours 50-100 ml/kg of body weight. After the first stage of rehydration, Regidron solution should be given at 10 ml / kg of body weight after each liquid stool. In children older than 3 years and adults, in the first 4-6 hours, the dose of Regidron solution can be 500-1000 ml, then 200 ml after each liquid stool. If diarrhea is accompanied by vomiting, then it is necessary to again give the patient a drink of Regidron solution after 10 minutes. after vomiting.
Side effect
In case of any unusual reactions, be sure to consult your doctor regarding the further use of the drug!
Overdose
With the introduction of too much or with the introduction of a too concentrated solution of Regidron, hypernatremia and hyperkalemia may occur. Metabolic alkalosis may occur in patients with reduced renal function. Symptoms of hypernatremia include weakness, neuromuscular agitation, drowsiness, confusion, coma, and sometimes even respiratory arrest. Metabolic alkalosis can manifest as decreased ventilation, neuromuscular excitation, and tetanic convulsions.
In case of severe overdose with severe consequences, the administration of Regidron should be discontinued. You need to see a doctor. Correction of the balance of electrolytes and fluid should be carried out by a physician based on laboratory data.
Application features
Severe dehydration (weight loss >10%, anuria) should be treated first with intravenous rehydration drugs. After that, Regidron can be used to treat diarrhea.
A sachet of the drug Regidron should be dissolved in 1 liter of water. If the dose is exceeded, the patient may develop hypernatremia. Patients in whom dehydration has developed against the background of renal failure, diabetes or other chronic diseases that disrupt the acid-base, electrolyte or carbohydrate balance require careful monitoring during treatment with Regidron, up to hospitalization.
If during the use of the drug Regidron the following situations occur, you should consult a doctor:
The patient has slow speech, he is quickly exhausted, drowsiness appears, he does not answer questions;
The temperature rises above 39°C;
The excretion of urine stops;
Liquid bloody stools appear;
Diarrhea lasts more than 5 days;
Diarrhea suddenly stops, severe pain appears;
If home treatment is unsuccessful or impossible.
Patient nutrition or breastfeeding should not be interrupted during oral rehydration therapy, or they should be continued immediately after rehydration. It is recommended to avoid foods rich in fats and simple carbohydrates. To prevent dehydration, the use of the drug Regidron should be started as soon as diarrhea begins. Usually the drug should be used for no more than three to four days, treatment is stopped with the end of diarrhea.
Regidron refers to drugs that restore acid-base and water-electrolyte balance in the patient's body. Regidron actively contributes to the correction of acidosis, neutralizes the negative consequences caused by severe dehydration of the body. Restores optimal fluid and electrolyte balance. The drug is recommended for use in diarrhea, as well as heat or sunstroke with concomitant increased sweating. Produced in the form of a powder intended for the preparation of solutions taken orally.1. Pharmacological action
Regidron is used for diarrhea and vomiting, as a result of which a violation of the acid-base balance develops, due to the loss of electrolytes along with water. The composition of the drug includes, which promotes the absorption of salts and citrates, which restore the acid-base balance.2. indications for use
- Maintenance and restoration of acid-base balance;
- Regidron is used for diarrhea of infectious origin;
- Regidron is taken to prevent blood pH disturbances;
- It can be used to maintain acid-base balance during intense sweating, due to physical or thermal stress.
3. How to use
The contents of 1 sachet of Regidron are dissolved in 1 liter of boiled water, and the solution is allowed to cool. It is necessary to take in small sips, before thoroughly stirring, after each liquid stool. For an hour, you need to take 10 ml / kg of body weight, after eliminating dehydration, the dose can be reduced to 5-10 ml / kg of body weight.When vomiting, an additional 10 ml / kg of body weight is used, after each attack of vomiting.
4. Side effects
Subject to the rules for the use and dosage of Regidron, side effects do not appear.5. Contraindications
6. During pregnancy and lactation
It can be used during pregnancy, since Regidron does not have a negative effect on the fetus.7. Interaction with other drugs
It is necessary to monitor the combination with drugs that require certain pH values for absorption, since Regidron has an alkaline reaction.8. Overdose
Hypernatremia and hyperkalemia may occur. Symptoms are arrhythmia, disturbance of consciousness, drowsiness, respiratory arrest is rarely observed. In case of violation of glomerular filtration, the development of metabolic alkalosis is possible. In case of an overdose of Regidron, the electrolyte balance is corrected.9. Release form
Powder 18.9 g. 4 or 20 pcs.10. Storage conditions
The prepared solution of Regidron is stored in the refrigerator for no more than 2 days, at a temperature of 2-8 degrees.11. Composition
1 pack of powder:
- sodium chloride - 3.5 g;
- sodium citrate - 2.9 g;
- potassium chloride - 2.5 g;
- dextrose - 10 g.
12. Terms of dispensing from pharmacies
The drug is released without a prescription.Found an error? Select it and press Ctrl + Enter
* Instructions for medical use for the drug Regidron published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST
