Phezam before or after meals. Phezam - instructions for the use of capsules, indications, active substance, side effects, analogues and price

The modern rhythm of life and frequent stresses have significantly increased the frequency of various diseases of the nervous system. Cerebral vascular diseases also contribute to these statistics. Therefore, nootropics and drugs that affect cerebral blood flow are among the most popular in the pharmacy network.

Regardless of the etiological cause of the disease, the mechanism of damage to brain cells is cell hypoxia and impaired intracellular neuronal exchange. Traumatic brain injuries, tumors, hypertension, cerebral atherosclerosis, cervical osteochondrosis and many other reasons can adversely affect the tone of the cranial vessels and the volume of blood entering the brain. Violation of the blood supply inevitably leads to a decrease in the delivery of oxygen and glucose to the tissues. The result is brain hypoxia and disruption of energy metabolism in cells. The situation is further aggravated by the fact that blood flow in the cerebral vessels most directly affects the pressure of the cerebrospinal fluid in the ventricles of the brain and meninges, and increased intracranial pressure leads to additional compression of the intracranial vessels and deterioration in the nutrition of brain cells. Cell resources are exhausted, and their death occurs. In this regard, it becomes clear that the main task of therapy for brain damage is the normalization of its blood supply and the activation of metabolic processes in cells.

For many years, cinnarizine and piracetam have been the basis for the treatment of neurological pathology. Cinnarizine is a selective calcium channel blocker. A decrease in the supply of calcium ions to the smooth muscle cells of arterioles leads to a decrease in their response to biogenic active substances that have a vasoconstrictive effect (dopamine, vasopressin, norepinephrine, etc.), and to a decrease in the tone of the vascular wall. A unique property of cinnarizine is an effective, but not excessive, vasodilating effect in relation to the vessels of the brain in the absence of a pronounced effect on peripheral arterial pressure. In addition, cinnarizine reduces blood viscosity and increases the plasticity of erythrocyte membranes, which favorably affects microcirculation processes. The moderate antihistamine activity of cinnarizine helps to reduce tissue swelling, which, combined with a decrease in the tone of the sympathetic nervous system and a decrease in the excitability of the vestibular apparatus, has the most favorable effect on the patient's condition.

Piracetam is a classic nootropic. Its main effects: stimulation of energy and protein metabolism in brain cells, improved glucose utilization, increased cell resistance to hypoxia and interneuronal transmission of nerve impulses in the central nervous system.

Since patients have to take several drugs at once for a long time, the combined drug Phezam ® was developed for the convenience of treatment. each capsule contains 400 mg of piracetam and 25 mg of cinnarizine.

The combination of these two active ingredients in one capsule allowed not only to reduce the number of tablets taken simultaneously, but also had the most favorable effect on the clinical effect of Phezam®. cinnarizine reduces excitability caused by piracetam; substances have a mutually potentiating effect in relation to the blood supply to brain tissues and metabolic processes in cells. This, in turn, reduced the likelihood of side effects. An additional plus for buyers is the affordable price of the medicine.

The use of Phezam ® helps patients with chronic cerebrovascular accident maintain a high intellectual level and physical activity, prevent disability and improve the quality of life.

Phezam ® is prescribed for children with intellectual retardation, with asthenic syndrome, problems associated with previous perinatal encephalopathy or traumatic brain injury. The existing age limit (the drug is not prescribed to children under 5 years of age) is associated exclusively with the form of release in the form of capsules: in young children, preference is given to liquid forms of drugs.

For young and middle-aged people, Phezam® helps to quickly recover from traumatic brain injuries, it is easier to endure mental stress during a session at an institute or at work. The drug is effective as a prophylactic for frequent headaches, including migraine.

Since 2010, Phezam ® has appeared in pharmacies in a new package.

The high safety profile of Phezam ® makes it indispensable in geriatric practice. Phezam ® is widely used in the treatment of encephalopathies of various origins, in senile dementia, in the complex therapy of strokes in the recovery period, both hemorrhagic and ischemic. The course use of the drug 2-3 times a year allows you to increase mental and physical activity in the elderly, significantly improve their quality of life.

The pharmacist can inform the patient about Phezam®. being confident in the effectiveness and safety of the proven drug, and the affordable price and large package containing 60 capsules, make it profitable and convenient for customers.

Phezam - instructions for use, analogues, reviews, price

Phezam is a combined drug from the group of nootropics that improve cerebral circulation and, as a result, brain function. The drug is used in the treatment of cerebrovascular disorders (eg, vascular atherosclerosis, cerebrovascular insufficiency), strokes. encephalopathies of various origins (for example, against the background of hypertension, craniocerebral injuries, past infections, etc.), dementia (dementia) of vascular origin, disorders of memory, attention and mental work, as well as labyrinthopathy, Meniere's syndrome and neurological pathology of childhood .

Composition, names and formulations Phezam

Currently, Phezam is available in a single dosage form - capsules for oral administration. Often these capsules are called tablets, which is not scientifically correct, but it is quite suitable for denoting a dosage form intended for oral administration. However, it should be remembered that when people say "Phezam tablets", they mean exactly the form for oral administration, that is, capsules. In addition, there is a common misnomer for the drug "Phezama", which is often used in everyday speech. Therefore, when you hear the term "Phezam", you should know that we are talking about the drug "Phezam".

Phezam contains two active ingredients:

1. Cinnarizine - 25 mg;

This means that each capsule contains 400 mg of Piracetam and 25 mg of Cinnarizine. Due to this content of active substances, the drug is often called "Phezam 400 + 25" in the slang of medical workers. When a person sees a similar name, do not be afraid, since we are talking about the same Phezam.

Phezam contains the following substances as auxiliary components:

Lactose;
Silicon dioxide colloidal;
magnesium stearate.

The capsule shell is 98% gelatin and 2% titanium dioxide dye.

Phezam capsules are dense, cylindrical in shape, painted white. Inside the capsules is a powdery mixture, painted in white or cream color. The powder inside the capsules may have small lumps, which, when lightly pressed with a dense object (for example, a spoon, glass rod, etc.), crumble and turn into powder. Phezam is available in packs of 60 capsules.

Phezam - mechanisms of action and scope of therapeutic application

The mechanism of action and therapeutic effects of Phezam are due to the active components that make up its composition. The general, resulting therapeutic and clinical property of Phezam is its ability to improve cerebral circulation and metabolism in the cells and nerve fibers of the brain. In fact, all other effects of Phezam are due precisely to the activation of blood flow and the intensification of metabolism in brain cells.

Since Phezam is a combination drug, which includes two active components, we will consider the properties of each of them and their resulting cumulative effect.

Piracetam is a nootropic agent that improves brain activity, having a positive effect on metabolic processes. Piracetam increases the rate of glucose consumption. which is the main nutrient for the brain, since the cells of the central nervous system are not able to receive the energy necessary to maintain vital activity and functioning from any other compounds. That is, under the influence of Piracetam, brain cells begin to actively feed, producing more energy, which is quite enough to ensure the intensive work of the organ. It is thanks to this that the speed of transmission of impulses between neurons increases, memory is activated, attention is concentrated and there is a general improvement in intellectual function.

In addition, Piracetam improves the blood supply to various parts of the brain in which there is vascular damage and moderate or mild oxygen starvation (ischemia). Due to the improvement of microcirculation in the brain, ischemia zones suffering from oxygen deficiency disappear, and the entire volume of neurons is included in intensive work. Improving blood flow is achieved not only through direct effects, but also indirectly, which consists in inhibiting platelet adhesion and, consequently, in preventing the formation of blood clots. Thus, Piracetam improves not only blood circulation, but also the properties of blood, making it as suitable as possible for circulation through microvessels. In areas of the brain prone to ischemia, Piracetam has a protective effect, increasing the resistance of neurons to hypoxia and death.

That is, Piracetam is able not only to improve cerebral circulation, but also to enhance the integrative function of the brain (the ability to synthesize and analyze, generalize, non-standard solutions, etc.), increase the productivity of intellectual work, consolidate memory, facilitate the learning process and the assimilation of new material and to restore and maintain brain function in the elderly.

Cinnarizine is a substance that has a pronounced effect directly on the vessels of the brain. Thus, cinnarizine dilates the vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances that constrict blood vessels. Cinnarizine dilates blood vessels, due to which the blood flow is activated, and the supply of various parts of the brain with oxygen and nutrients is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissues to a lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and arterial pressure.

Together, Cinnarizine and Piracetam enhance the effects of each other, so the severity of the resulting action of Phezam is higher compared to the use of drugs in isolation with a separation in time of administration. However, in Phezam, the sedative effect of Cinnarizine prevails, due to which a person does not feel psychomotor agitation, as when using Piracetam.

Phezam - indications for use (from which Phezam tablets)

Phezam is currently indicated for use in the treatment of various diseases and conditions associated with cerebrovascular accidents and injuries. as well as disorders of integrative function. However, not all of these conditions are included in the list of official indications for the use of the drug, since their effectiveness has not been scientifically proven. Therefore, we provide only a list of approved, official indications for the use of Phezam.

So, indications for the use of Phezam is the treatment of the following diseases or conditions:

Violation of the mental function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or think about the situation from different points of view, etc.);
Violation of concentration;
mood disorders;
Intoxication of any origin;
Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
Encephalopathy of various origins (against the background of chronic hypertension, traumatic brain injury, infection, surgery, anesthesia, etc.);
Dementia (dementia) due to vascular pathology;
Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
Labyrinthopathy (pathology of the structures of the inner ear), manifested by tinnitus. nausea, vomiting, nystagmus. motion sickness;
Meniere's syndrome;
Aphasia (speech disorder) provoked by vascular pathology;
Prevention of kinetosis (sickness, "seasickness", etc.);
Prevention of migraine;
Mild neurological pathology in children (poor learning, low concentration, insufficient long-term memory, etc.);
In a comprehensive methodology for teaching children who have a lag in intellectual development.

Phezam (tablets) - instructions for use

Phezam capsules must be taken orally, swallowed whole, without chewing, without violating the integrity of the shell and without pouring the powder into a glass of water. The capsule should be washed down with a small amount of water (at least half a glass) or any other liquid, with the exception of carbonated sugary drinks, coffee and caffeinated energy drinks. For example, Phezam capsules can be washed down with mineral water. juice, tea, compote, fruit drink and other drinks. The only condition that Phezam's drinking liquid must satisfy is a low temperature, that is, the drink should not be hot, but warm or cool.

Phezam capsules can be taken at any convenient time, regardless of the meal. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after eating. Moreover, a light snack, for example, an apple, is quite suitable as a meal. banana or other fruit, sandwich, piece of meat, etc.

You should try to always take Phezam capsules at the same time, for example, every day at 9-00 am, or daily at 8-00 and 18-00, depending on how many times a day it is recommended to drink the drug. Moreover, if a person missed a dose at the set time, then you should drink the capsule immediately, if the next term for taking Phezam has not come. If, after the missed capsule, the time for taking the next one has come up, then you should drink only one, not two, without trying to compensate for the forgotten dose of the drug.

For the treatment of various diseases, adults should take Phezam 1 - 2 capsules three times a day, for one to three months. Children over 5 years old, but under 18 years of age, also for the treatment of various diseases and conditions, Phezam should take 1 - 2 capsules, but only once or twice a day for 1.5 - 3 months. The duration of the course of therapy is determined by the severity of the disease and the rate of clinical improvement. You can not take Phezam for more than three months without a break. If necessary, treatment courses can be repeated 2-3 times during one calendar year.

Phezam overdose

An overdose of Phezam during the entire period of use of the drug has been recorded in a very limited number of times. The drug is safe, and even exceeding the therapeutic dosage by several times did not cause pronounced side effects that would force a person to stop taking Phezam. The only symptom of Phezam overdose in adults may be abdominal pain. which, as a rule, is normally tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations or convulsions.

If any symptoms of an overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at stopping discomfort. In addition, it is recommended to carry out a gastric lavage. An overdose of Phezam can also be removed with hemodialysis.

Special instructions for the use of Phezam

Athletes should cancel the drug 2 to 3 days before doping tests, since cinnarizine contained in Phezam can give a positive test result.

In addition, the use of Phezam can give a false positive result of a study for the determination of radioactive iodine. since the composition of the capsule dye contains this trace element. Phezam also activates the thyroid gland. as a result, a person may experience tremor (trembling) of various parts of the body and anxiety.

If Piracetam causes insomnia and tension in a person, then Phezam should be replaced, which in such situations is the optimal drug. Phezam is also the drug of choice if doctors have prescribed Cinnarizine and Piracetam at the same time (this may be the appointment of different doctors).

Against the background of the use of Phezam, care should be taken when working with various mechanisms, including when driving, since cinnarizine at the initial stages of therapy can provoke drowsiness.

While taking Phezam, you should refrain from drinking alcohol, as this will provoke a massive death of brain cells.

When Phezam is used in people suffering from liver diseases. transaminase activity (AST, ALT) should be monitored once a week. With an increase in transaminase activity by more than 1.5 times from the upper limit of the norm, Phezam should be discontinued.

If a person has kidney disease, before prescribing Phezam, creatinine clearance should be determined using the Reberg test. If the creatinine clearance is more than 60 ml / min, then Phezam can be taken at the usual dosage, monitoring this laboratory indicator every 3 to 4 days. If the creatinine clearance was initially less than 60 ml / min or fell during the use of the drug, then the Phezam dosage should be halved and the intervals between doses should be increased.

Use during pregnancy and lactation

During experiments on animals, the absence of any negative effect of Phezam on the growth and development of the fetus was revealed. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in the mental state of a woman, increased anxiety. lability of the emotional sphere and mood, which theoretically can have a bad effect on the course of pregnancy.

Because Phezam passes into milk. it is also contraindicated during breastfeeding. If a woman who is breastfeeding must take Phezam for any reason, then the baby should be transferred to artificial mixtures.

Interaction with other drugs

Phezam, when taken simultaneously, enhances the effect of sedatives, other nootropics, antihypertensives and alcoholic beverages. Moreover, Phezam enhances only the inhibitory effect on the central nervous system of all the listed groups of drugs.

Taking drugs that dilate blood vessels and lower blood pressure. causes all Phezam effects to be enhanced. Accordingly, drugs that narrow blood vessels and increase pressure, on the contrary, weaken the effects of Phezam.

Phezam improves the subjective tolerance of drugs from the group of neuroleptics and antidepressants.

Phezam: before or after meals - how to take

In many instructions for the use of Phezam, which are available on the leaflets, the inserts do not indicate how to take the drug with respect to food intake. Usually, if it is not specifically indicated how to take the drug - before, during or after a meal, this means that it can be used regardless of food, at any convenient time. This rule is also true for Phezam, which can really be taken regardless of food intake at any time convenient for a person.

However, experienced doctors or people who have used this drug repeatedly recommend taking it half an hour after eating. This option was chosen empirically as the optimal one, when they tried various ways of taking Phezam - during, before or after meals. The empirical conclusion that it is best to take Phezam half an hour after a meal is based on the fact that it is with this option that side effects are the least likely to develop, and the drug is well tolerated.

If Phezam needs to be taken several times a day, and full meals are not possible for some reason, then you can just have a snack with something, for example, an apple, a banana, nuts, a bun, a sandwich, etc. instead of lunch, afternoon tea or dinner. A small amount of food that has entered the stomach will completely replace a full meal in terms of minimizing the discomfort from the use of Phezam. Remember that the phrase "after a meal" does not mean that you must consume a complete lunch, dinner, breakfast or afternoon snack from your point of view. It only means that before taking the drug, you need to eat something, for example, a piece of bread, fruit, a sandwich, a piece of jelly or cold meat from soup, etc.

Phezam children

Phezam is used for therapy in children older than 5 years of age. If necessary, the use of Phezam in children from one year is allowed.

Phezam in children and adolescents normalizes sleep, eliminates nightmares, stops night awakenings, and reduces fatigue. increases efficiency, both mental and physical, and also relieves irritability. emotional instability, mood lability and excessive vulnerability. In addition, Phezam reduces the frequency of headaches in children, improves adaptation in a school or preschool team, stabilizes and maintains normal blood pressure, preventing its jumps. In general, Phezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Phezam is used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist. and not a psychiatrist, since it is not suitable for the treatment of severe mental illness, but it can be successfully used to eliminate minor disorders.

After the course of application, the child becomes balanced, less whiny, focused, attentive, he is not so quickly and easily upset, his mood does not change within one minute several times, he sleeps much more calmly at night, and mastering speech and other skills is more successful and faster. . Such positive changes, combined with good tolerability of the drug, allow doctors and parents to consider Phezam an effective drug and use it to improve mental performance and development of children.

In addition, Phezam is successfully used in children for the treatment of perinatal lesions of the central nervous system, recovery from traumatic brain injuries and past infectious diseases. In such situations, the drug normalizes brain function, reduces headaches, stabilizes night sleep, and also improves adaptation in a team and learning ability. Phezam can also improve the condition and promote the recovery of children with autism and mild neurological disorders.

Phezam side effects

Phezam is overwhelmingly well tolerated and rarely causes side effects. According to international standards, all side effects are classified into several groups depending on the frequency of their occurrence. Regarding Phezam, it was found that all side effects are recorded either sometimes or rarely. Moreover, “sometimes”, according to the international classification, means that the effect develops in less than one person out of a hundred, but more than 1 out of 1000. And “rarely” means that a side effect develops in more than 1 person out of 10,000 , but less than 1 in 1000. All Phezam side effects are transient, that is, they disappear on their own after the drug is discontinued and do not require any special treatment.

The side effects of Phezam include the following symptoms from various organs and systems:

1. From the side of the central nervous system:

Hyperkinesis (twitching of limbs, excessive movements, etc.);
Nervousness;
Drowsiness;
Depression;
Dizziness;
Headache;
Ataxia (impaired coordination of movements);
imbalance;
Insomnia;
Confusion;
Excitation;
Anxiety;
hallucinations.

2. From the gastrointestinal tract:

Disinhibition of sexual behavior;
Increased sexual desire;
Increase in body weight;
Tremor of the limbs;
Increased muscle tone.

Contraindications to the use of Phezam

There are relative and absolute contraindications to the use of Phezam. Absolute conditions are those in which the drug cannot be used under any circumstances. And contraindications are relative, in which the drug can be used with caution and under the supervision of a physician.

Absolute contraindications to the use of Phezam are the following diseases and conditions:

Severe renal failure. at which the creatinine clearance is less than 20 ml / min;
severe liver failure;
Psychomotor agitation present at the time of administration of the remedy;
Chorea of Huntington;
Acute hemorrhagic stroke;
Pregnancy;
Breast-feeding;
Age under 5 years;
Sensitivity or individual intolerance to the components of the drug.

Relative contraindications to the use of Phezam are the following conditions or diseases:

Phezam - analogues

Currently, there are analogues and synonyms of Phezam on the pharmaceutical markets of Russia and the countries of the former USSR. Synonyms are called drugs containing exactly the same active substances as Phezam. Analogues are drugs containing various active substances (not the same as in Phezam), but having similar therapeutic and pharmacological effects.

Today, the following preparations-synonyms of Phezam are on sale:

Combitropil capsules;
NooKam capsules;
Omaron tablets;
Piracesin capsules.

Phezam's analogues are the following drugs:

1. Acephen tablets;

2. Bravinton concentrate;

3. Vero-Vinpocetine tablets;

6. Vinpocetine forte tablets;

26. Nooklerin solution;

27. Noopept tablets;

28. Nootropil capsules, tablets and solution;

29. Omaron tablets;

30. Pantogam syrup and tablets;

31. Pantocalcin tablets;

32. Picamilon tablets and solution;

33. Piracesin capsules;

39. Celestab capsules;

40. Cellex solution;

41. Ceraxon solution;

42. Cerebrolysate solution;

44. Encephabol tablets and suspension;

45. Epithalamin powder;

46. Escotropil solution.

Instructions for use of Phezam: pharmacological action, indications, method of administration and doses, side effects, contraindications, analogues - video

Phezam (tablets) - reviews

Reviews about Phezam vary, among them approximately 60% are positive and 40% are negative. Positive feedback is due to a visible clinical improvement in a person's condition, normalization of memory, attention and increased mental performance, which were observed after a course of application. Also, positive reviews about Phezam are associated with its ability to reduce stress and anxiety during any stressful moments in life, for example, passing exams, interviewing for a good job, etc. In addition, people, as a positive effect of Phezam, note its ability to stop dizziness and headaches caused by vascular pathology. In such cases, people take Phezam not in a course, but periodically as needed, as a remedy, for example, for a headache.

Phezam causes insurmountable drowsiness in some people, which forces them to take the drug only in the evenings or after work. However, someone is ready to tolerate this minus of the drug, generally considering it good because of other positive effects, and, accordingly, leaving a positive review. And other people cannot tolerate such a property of the drug, as a result of which they are forced to refuse to take it, and therefore leave a negative review about Phezam.

In addition, the negative reviews about Phezam are due to the lack of the expected effect and unpleasant side effects that forced them to stop taking the drug. People also leave negative reviews with the development of a slight improvement, which does not significantly change the general condition of a person.

Reviews of doctors

Doctors' reviews of Phezam are usually positive, which is due to the effectiveness of the drug in many people, as well as the fact that it can replace several drugs. In addition, the positive opinion of doctors is due to the rare side effects that occur when Phezam is used, which allows you to be calm about the patient's condition and not select the dosage for a long time. Also, an important advantage of the drug is its low cost, at which it can be purchased by almost all patients.

Negative reviews of doctors about Phezam are usually due not to clinical observations and experience, but to the lack of scientific evidence of its effectiveness. Based on the fact that the clinical effects of the drug have not been scientifically proven, some doctors a priori consider Phezam not a medicine, but a “dummy”, and leave only negative reviews about it.

However, such categoricalness does not always reflect the truth, since even a drug with unproven efficacy can have a pronounced therapeutic effect in many people, subjectively improving their condition. And even such an effect cannot be called useless, because a person’s well-being improves and the quality of life, respectively, too. Of course, Phezam may not cure severe diseases, but mild disorders and painful symptoms can help to eliminate.

What is better than Phezam?

In medical science and practice, the term “best” is not used, since each person is individual, and all possible effects from the interaction of the body with a chemical compound cannot be predicted, and therefore it is simply impossible to single out a drug that is equally good for everyone. Doctors and scientists instead of the concept of "best" use the term "optimal", the meaning of which is that this particular drug in this particular situation is the best for a person. All this is true for Phezam.

Therefore, if Phezam is not suitable for a person, or he wants to get the best effect, then you should look for another drug with similar properties among analogues. And the one that satisfies all wishes will be "better than Phezam."

Phezam - price

Since Phezam is produced by domestic pharmaceutical factories, its cost is relatively low. And differences in cost in retail sales are due to the selling price, transportation and storage costs, as well as the retail markup of a particular pharmacy chain. In principle, the drug production technology is the same and is used in all pharmaceutical enterprises, so there is no difference between a more expensive and a cheaper drug. Because of this, you can safely buy the drug at the lowest price offered. Currently, Phezam is sold in pharmacies in Russian cities at a price of 170 to 238 rubles per pack of 60 capsules.

Where can I buy?

Currently, Phezam is officially sold by prescription, so you can only buy the drug in a regular pharmacy. However, pharmacists often sell the drug without a prescription or only on the basis of an entry in a person's medical record. But such luck may not be permanent, so if you need to buy Phezam, it is better to consult a doctor for a prescription.

When buying, you should pay attention to the shelf life of the drug, which is 3 years from the date of production. Phezam must be stored in a dark place at an air temperature not exceeding 25 o C. Violation of storage conditions leads to the loss of active properties, which weakens the therapeutic effect of Phezam.

Before use, you should consult with a specialist.

heal-cardio.ru

Phezam

Phezam is a nootropic and psychostimulant drug based on the active ingredients Cinnarizine and Piracetam. The drug is widely used to normalize blood flow in the brain, activate mental processes in various pathologies. The instructions for use presented in this article contain all the information on the rational use of the product. Data on prices, Russian and foreign analogues of Phezam (substitutes), reviews of patients and doctors will allow patients to choose the most suitable drug.

Compound

The active substances in Phezam (international name Phezam) are:

Cinnarizine - 25 mg per dose.
Piracetam - 400 mg per dose.

Other Ingredients:

gelatin;
lactose;
titanium oxides;
silicon oxides;
magnesium salts.

Phezam is produced in the form of hard capsules having a cylindrical shape (for internal use), painted white. The manufacturer Balkanfarma produces a medical product of 20 or 60 capsules in one package, which contains the official version of the annotation approved in Russia (instructions for use).

pharmachologic effect

The combined medicine Phezam belongs to the pharmacological groups of psychostimulants, nootropic drugs. Different mechanisms of action of the ingredients of the product provide the following pharmacological actions:

improvement of cognitive functions;
activation of metabolism in the brain;
stimulation of the propagation of nerve impulses in neurons;
acceleration of blood flow due to improved blood viscosity;
improving the connections that exist between the hemispheres of the brain;
blocking of calcium channels;
antihistamine effect (slightly expressed) due to Cinnarizine, which is present in the preparation;
decrease in the vasoconstrictive action of serotonins and epinephrines;
increasing the resistance of nerve tissues to oxygen deficiency;
prevention of attacks of dizziness.

The drug is rapidly absorbed, excreted mainly in the urine.

Indications for use

The manufacturer, based on the descriptions of the studies of the drug, approved the following indications for use:

circulatory failure in the brain;
violation of blood flow in the brain due to a stroke;
cerebrostenia, which develop as a result of various brain injuries;
encephalopathy;
syndromes accompanied by impaired attention, thinking, memory, learning abilities;
labyrinthopathy, which are characterized by dizziness, bouts of nausea, tinnitus, frequent vomiting;
prevention of motion sickness and seasickness;
Meniere's syndromes.

Among the contraindications for use, the manufacturer identifies a number of diseases and conditions:

allergy to the ingredients of the medicine;
insufficiency of functioning of the kidneys, especially in severe forms;
violations of blood flow in the brain in acute forms;
Parkinson's disease;
chorea;
porphyria;
different types of psychomotor agitation;
childhood. Phezam is not prescribed for children under 16 years of age;
increased intraocular pressure;
pregnancy;
feeding the baby with breast milk. Phezam is not used by breastfeeding women during postpartum lactation.

Adults use Phezam (nootropic agent) only inside after meals. The drug is important to drink at least 100 ml of water.

Reception schedule - 1-2 capsules three times a day - before lunch (morning), lunch and evening (after lunch). Duration of admission - from 1 to 3 months (taking into account the patient's condition).

Important! It is forbidden to repeat more than three courses of treatment in a row.

It is allowed to conduct 2 or 3 courses of taking the drug throughout the year in compliance with the method of application indicated in the instructions.

Overdose

The most common consequences of an overdose of the drug are the following symptoms (according to information in the Vidal reference book):

dyspepsia (soreness in the abdomen, vomiting, diarrhea with blood impurities);
disturbances of consciousness;
drowsiness;
hypotension (lowering pressure);
anxiety;
sleep disorders;
trembling of the limbs;
nightmares;
convulsions.

The most effective measures of assistance are the following:

gastric lavage;
reception of sorbents (activated carbon);
hemodialysis;
symptomatic treatment.

Side effects often develop with prolonged use of the drug. The most likely adverse reactions to Phezam are as follows:

allergy;
disorientation in space;
trembling of the limbs;
headache;
stomach ache;
increased fatigue;
stagnation of bile;
skin rashes;
depressive states;
increased sweating;
weight gain;
diarrhea.

Important! To prevent side effects of the drug, you should adhere to the prescribed doses.

Phezam enhances the effect of such means:

Thyroid hormones.
Antidepressants.
Nootropics.
Vasodilators.
Hypotensive.
Anticoagulants.

Phezam does not have a significant effect on the effectiveness of other drugs.

During pregnancy and lactation

Phezam is not prescribed for breastfeeding children and pregnancy. It has been proven that the drug is characterized by rapid penetration through the placenta and into breast milk, which can have a negative effect on the condition of the fetus and newborn.

With alcohol

In the case of the interaction of Phezam with alcohol, the sedative effect of ethanol is enhanced. It is important to exclude the combination of Phezam and alcohol during treatment due to poor compatibility.

Analogues

The following analogues (synonyms) of Phezam in Russia are presented on the market:

Memozam;
Noosam;
Evryzam;
Omaron - domestic analogue of Phezam (Russian);
Neuro-Norm;
Cinatropil;
Cysam;
Fescetam.

Important! The combination of Piracetam with other nootropic drugs (Cinnarizine, etc.) is more effective in many diseases than single-component drugs.

products containing Citicoline - Kvanil, Somazina, Neuroxon, Somazina;
Aminalon;
preparations containing Piracetam - Lucetam (tablets), Nootropil, Piracetam;
products containing Phenibut - Noofen, Bifren, Phenibut;
medicines containing Vinpocetine - Vinpocetine, Neurovin, Cavinton;
Glycine;
products containing hopantenic acid - Pantocalcin, Cognum;
Betaserc;
Noopept;
combined drugs - Ceregin, Olatropil, Thiocetam;
Picamilon;
Cortexin;
Pramistar;
Phenotropil;
Cerebrolysin;
Mexidol. Phezam in severe cases can be combined with Mexidol at the discretion of the doctor;
Mexicor;
Cerepro;
Encephabol.

Important! Lists of analogues, including cheaper ones, are quite large. Phezam can be replaced by other means only on the recommendation of the attending physician.

Phezam is stored for three years from the date of production. After the expiration date, the medicine should not be taken.

Terms of sale and storage

Phezam is sold in pharmacies with prescriptions written by doctors in Latin. Be sure to indicate the INN of the active substances in the prescription form or the name of the drug in Latin.

Phezam is stored at a temperature not exceeding 25 ° C in dry, well-ventilated areas away from direct light rays and children (parents should be especially careful).

special instructions

It is important to adjust the dose of the drug in patients who suffer from kidney disease. For them, it is required to reduce the dosage or increase the intervals between Phezam's doses.

During treatment with the drug in patients with liver pathologies, the level of liver enzymes should be regularly examined.

Phezam should be used with caution in persons suffering from an increased tendency to hemorrhage, bleeding, stroke. The dose should be adjusted in patients who regularly or temporarily take anticoagulants. The use of the drug in patients with lactase deficiency should be avoided.

Care should be taken to drive a car during treatment with the drug, as dizziness and vestibular disorders may occur.

Price

The cost of Phezam No. 60 differs in different regions of the country. One pack of Phezam costs from 300 rubles.

Phezam capsules contain two active ingredients - piracetam And cinnarizine .

As additional ingredients in the composition of the product are present: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

The capsule shell consists of gelatin and titanium dioxide.

Release form

The Phezam preparation is produced in the form of cylindrical capsules, gelatinous, hard, size No. 0. Capsules are white, inside is a mixture of powder, which has a white or almost white color. The composition of the contents inside may contain conglomerates that turn into powder if you press on them.

Contains in blisters on 10 pieces, blisters are put into cardboard packs.

pharmachologic effect

The abstract indicates that Phezam is a combined remedy that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in the resistance of cerebral vessels, improving blood flow in these vessels.

As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that make up Phezam. The main effect that is noted after taking the medicine is an improvement blood circulation in the brain and metabolic processes in nerve fibers and brain cells.

Substance piracetam It has a nootropic effect, activating the activity of the brain, positively affecting the metabolism in the body. Under the action of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active nutrition of cells occurs, which leads to the production of more energy and activation of brain function. Piracetam helps to increase the speed of transmission of impulses between neurons. As a result, memory increases, concentration of attention improves, which leads to an increase in intellectual function.

Also, piracetam helps to improve blood flow in those parts of the brain where there are damaged vessels, and it is also noted i.e. oxygen starvation. Since microcirculation improves, the ischemic zones that have arisen due to lack of oxygen disappear, and the entire volume of neurons participates in the work of the brain.

In addition, there is an indirect effect of this component, which contributes to the activation of blood flow. It is provided by inhibiting the process of gluing platelets, which in fact is the prevention of the appearance of blood clots. That is, the piracetam component not only activates blood flow, but also improves its properties. Thus, the blood circulates more actively through the microvessels.

Under the influence of piracetam, the resistance of neurons to . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and provides restoration and support of brain functions in elderly people.

Substance cinnarizine expressed directly affects the vessels of the brain, expanding them. Also, under the influence of this substance, the tone of smooth muscles decreases, their reaction to active substances that constrict blood vessels decreases. Due to the fact that the substance expands the blood vessels, the blood flow is activated, and more oxygen and nutrients enter the brain. In view of the improvement in blood flow, the resistance of brain tissues to oxygen deficiency also increases. At the same time, despite the vasodilating effect, cinnarizine does not affect the indicators of arterial and .

The presence of two of these components in Phezam at once provides a mutual enhancement of the effects of the active components. Therefore, the severity of the effect of the drug is more pronounced compared to taking these components separately.

When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the drug does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.

Pharmacokinetics and pharmacodynamics

After the patient has taken Phezam tablets, the active substances are completely absorbed from the gastrointestinal tract.

The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The level of bioavailability of piracetam is 100%.

Piracetam does not bind to plasma proteins, cinnarizine binds by 91%. Penetrates through the BBB, is determined in all tissues and organs, passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.

The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.

The half-life of piracetam is 4-5 hours (from the blood), 8.5 hours (from the cerebrospinal fluid). It is mainly excreted through the kidneys.

The half-life of cinnarizine is 4 hours. Metabolites are excreted for the most part in the urine, as well as in the feces.

In people with renal insufficiency, the half-life of piracetam is increased.

Phezam indications for use

Before using Phezam, the indications for use must be taken into account. The drug is prescribed in such cases:

with insufficient blood flow in the brain (in the case of vessels, during the recovery period after suffering an ischemic or hemorrhagic , with encephalopathy of various origins, after traumatic brain injury);
when intoxication ;
in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, a deterioration in attention, memory, mood;
with psychoorganic syndrome, in which symptoms predominate asthenia And adynamia ;
consequences of traumatic brain injury;
labyrinthopathy (sensation of tinnitus, dizziness, nausea and vomiting);
asthenic syndrome associated with psychogenic origin;
Meniere's syndrome ;
for the purpose of prevention , kinetosis ;
in the complex therapy of children with psychoorganic syndrome, which led to low learning ability.

Contraindications

Phezam should not be taken in the following cases:

in severe forms of renal and hepatic insufficiency;
during the period of increased psychomotor agitation;
at chorea of Huntington ;
during pregnancy and breastfeeding;
at the age of the patient up to 5 years;
with high sensitivity to the components of the remedy.

The drug is prescribed with caution to those patients who are diagnosed with , violations hemostasis , liver or kidney dysfunction, severe.

Phezam side effects

During treatment, the following side effects are possible:

nervous system: nervousness, feeling of drowsiness, hyperkinesia; in rare cases - headaches, , , ataxia , agitation, anxiety;
allergic manifestations: in rare cases - a rash on the skin, , swelling, itching, photosensitivity.
digestive system: severe salivation, nausea, vomiting, abdominal pain, ;
other manifestations: increased libido.

Phezam tablets, instructions for use (Method and dosage)

That instruction for the use of Phezam, which is provided in the annotation to the drug, indicates that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years of age are indicated to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. You need to take the capsules by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of water, and it should not be hot.

Many users ask about the capsules, how to take it - before or after a meal. The instructions say that there is no particular difference in whether to take the remedy before meals or after meals. But it is optimal to drink capsules 20-30 minutes after a meal. It is advisable to drink the medicine at the same time every day.

Doctors warn that it is impossible to take the medicine for longer than 3 months - a break is needed between courses.

Overdose

As a rule, Phezam is well tolerated by patients and when taking large doses of the drug, there are no significant side effects, which requires discontinuation of treatment. In case of overdose, patients may experience abdominal pain. When taking too large doses of the drug, you need to rinse the stomach, induce vomiting. If there is such a need - to carry out hemodialysis and symptomatic treatment. There is no specific antidote.

Interaction

Not all drugs can be taken Phezam tablets at the same time, from which the interaction of this drug with other drugs should be taken into account.

When taken simultaneously with Phezam, drugs that inhibit the action of the central nervous system, ethanol, tricyclic antidepressants, their sedative effect may increase.

When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.

Vasodilator drugs enhance the effect of Phezam.

Due to the presence of cinnarizine in the composition of the drug, the activity decreases hypertensive drugs .

With the simultaneous administration of Phezam, an increase in the activity of thyroid hormones is noted, which can lead to the manifestation of tremor and anxiety.

Due to the antihistamine action, cinnarizine can mask the manifestation of positive reactions in relation to skin reactivity factors during skin tests. To avoid this effect, it is necessary to stop using the drug 4 days before such tests.

Phezam may enhance the effect of oral anticoagulants.

Terms of sale

You can buy Phezam capsules by prescription.

Storage conditions

It is necessary to store the medicine at temperatures up to 25 ° C, in a dark place. Keep out of reach of children.

Best before date

The shelf life of the capsules is 3 years.

special instructions

If Phezam is prescribed to patients who have impaired liver function, it is necessary to monitor the content of liver enzymes.

The drug activates the functions of thyroid hormones, which is why patients undergoing treatment may experience a feeling of anxiety and tremor.

Since cinnarizine can provoke drowsiness, during the period of treatment you need to drive carefully and work with precise and dangerous mechanisms.

In the treatment of elderly people, it is necessary to regularly monitor the indicators of kidney function and, if necessary, adjust the dose.

Active components are able to penetrate through the filter membranes of devices for .

The medication should be avoided if porphyria .

When taking Phezam, a false positive result may occur during doping control among athletes, also due to the presence of iodine-containing dyes in the capsule shell, there may be a false positive result in the test for the determination of radioactive iodine.

Since piracetam reduces aggregation platelets , it is necessary to carefully prescribe it in violation of hemostasis in patients, as well as in conditions accompanied by hemorrhages. You should not take medicine for complex surgical operations, with severe bleeding and hemorrhagic strokes in history.

Phezam can provoke irritation in the epigastric region, when it is used after eating, there may be a decrease in the severity of gastric irritation, for which the medicine should be carefully used by patients suffering from gastrointestinal diseases.

It should be noted that the composition of the product as an auxiliary component contains lactose .

Phezam's analogs

Coincidence in the ATX code of the 4th level:

Both Phezam and its analogues should be prescribed by a doctor after an accurate diagnosis. Active ingredients similar to those contained in Phezam are included in the preparations combitropil , , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.

Also, drugs have a similar pharmacological effect on the patient's body:, Vinpocetine , Demanol , Memotropil , combitropil , Pantogam , Pyriditol , Cellex , encephabol and etc.

Omaron or Phezam - which is better?

The tool is an analogue of this drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the medicine Omaron is lower compared to Phezam.

Alcohol compatibility

Alcohol and Phezam cannot be used at the same time, according to the instructions for the drug. With their simultaneous administration, the risk of stroke increases, and a negative effect on the state of the liver is also noted. Therefore, during the treatment period, you must completely abandon alcohol.

children

Children under 5 years of age are not prescribed these capsules. Children after 5 years of age should be given the medicine strictly according to the scheme prescribed by the doctor. Reviews of doctors and parents indicate that with the help of this medicine in school-age children, you can normalize sleep, improve performance, and relieve irritability.

During pregnancy and lactation

The use of Phezam during pregnancy is contraindicated, although there is no information on the negative effect of the active components. Piracetam passes into breast milk, so the drug should not be used during lactation.

Thank you

Phezam is a combined drug from the group of nootropics that improve cerebral circulation and, as a result, brain function. The drug is used in the treatment of cerebral circulation disorders (for example, vascular atherosclerosis, cerebrovascular insufficiency), strokes, encephalopathies of various origins (for example, against the background of hypertension, traumatic brain injuries, previous infections, etc.), dementia (dementia) of vascular origin, disorders of memory, attention and mental work, as well as labyrinthopathy, Meniere's syndrome and neurological pathology of childhood.

Composition, names and formulations Phezam

Phezam is currently available in a single dosage form - capsules for oral administration. Often these capsules are called tablets, which is not scientifically correct, but it is quite suitable for denoting a dosage form intended for oral administration. However, it should be remembered that when people say "Phezam tablets", they mean exactly the form for oral administration, that is, capsules. In addition, there is a common misnomer for the drug "Phezama", which is often used in everyday speech. Therefore, when you hear the term "Phezam", you should know that we are talking about the drug "Phezam".

Phezam contains two active ingredients:
1. Cinnarizine - 25 mg;
2. Piracetam - 400 mg.

Phezam contains the following substances as auxiliary components:

Silicon dioxide colloidal;
magnesium stearate.

The capsule shell is 98% gelatin and 2% titanium dioxide dye.

Phezam - mechanisms of action and scope of therapeutic application

Since Phezam is a combination drug, which includes two active components, we will consider the properties of each of them and their resulting cumulative effect.

Piracetam is a nootropic agent that improves brain activity, having a positive effect on metabolic processes. Piracetam increases the rate of consumption of glucose, which is the main nutrient for the brain, since the cells of the central nervous system are not able to receive the energy necessary to maintain life and function from any other compounds. That is, under the influence of Piracetam, brain cells begin to actively feed, producing more energy, which is quite enough to ensure the intensive work of the organ. It is thanks to this that the speed of transmission of impulses between neurons increases, memory is activated, attention is concentrated and there is a general improvement in intellectual function.

Cinnarizine is a substance that has a pronounced effect directly on the vessels of the brain. Thus, cinnarizine dilates the vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances that constrict blood vessels. Cinnarizine dilates blood vessels, due to which the blood flow is activated, and the supply of various parts of the brain with oxygen and nutrients is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissues to a lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and arterial pressure.

Phezam - indications for use (from which Phezam tablets)

Phezam is currently indicated for use in the treatment of various diseases and conditions associated with cerebrovascular accident, trauma, and integrative function disorders. However, not all of these conditions are included in the list of official indications for the use of the drug, since their effectiveness has not been scientifically proven. Therefore, we provide only a list of approved, official indications for the use of Phezam.

So, indications for the use of Phezam is the treatment of the following diseases or conditions:

Cerebral circulation disorders of any origin (atherosclerosis of cerebral vessels, subacute or chronic stroke, recovery period after hemorrhagic stroke, traumatic brain injury, osteochondrosis of the cervical spine, etc.);
Recovery after a traumatic brain injury;
memory impairment;
Violation of the mental function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or think about the situation from different points of view, etc.);
Violation of concentration;
mood disorders;
Intoxication of any origin;
Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
Encephalopathy of various origins (against the background of chronic hypertension, traumatic brain injury, infection, surgery, anesthesia, etc.);
Dementia (dementia) due to vascular pathology;
Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
Labyrinthopathy (pathology of the structures of the inner ear), manifested by tinnitus, nausea, vomiting, nystagmus, motion sickness;
Meniere's syndrome;
Aphasia (speech disorder) provoked by vascular pathology;
Prevention of kinetosis (sickness, "seasickness", etc.);
Prevention of migraine;
Mild neurological pathology in children (poor learning, low concentration, insufficient long-term memory, etc.);
In a comprehensive methodology for teaching children who have a lag in intellectual development.

Phezam (tablets) - instructions for use

Phezam capsules must be taken orally, swallowed whole, without chewing, without violating the integrity of the shell and without pouring the powder into a glass of water. The capsule should be washed down with a small amount of water (at least half a glass) or any other liquid, with the exception of carbonated sugary drinks, coffee and caffeinated energy drinks. For example, Phezam capsules can be washed down with mineral water, juice, tea, compote, fruit drink and other drinks. The only condition that Phezam's drinking liquid must satisfy is a low temperature, that is, the drink should not be hot, but warm or cool.

Phezam capsules can be taken at any convenient time, regardless of the meal. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after eating. Moreover, a light snack is quite suitable as a meal, for example, an apple, a banana or other fruit, a sandwich, a piece of meat, etc.

Phezam overdose

An overdose of Phezam during the entire period of use of the drug has been recorded in a very limited number of times. The drug is safe, and even exceeding the therapeutic dosage by several times did not cause pronounced side effects that would force a person to stop taking Phezam. The only symptom of Phezam overdose in adults may be abdominal pain, which is usually well tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations or convulsions.

If any symptoms of an overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at stopping discomfort. In addition, it is recommended to carry out gastric lavage. An overdose of Phezam can also be removed with hemodialysis.

Special instructions for the use of Phezam

Athletes should cancel the drug 2 to 3 days before doping tests, since cinnarizine contained in Phezam can give a positive test result.

In addition, the use of Phezam can give a false positive result of a study for the determination of radioactive iodine, since this microelement is contained in the capsule dye. Phezam also activates the thyroid gland, as a result of which a person may experience tremor (trembling) of various parts of the body and anxiety.

While taking Phezam, you should refrain from drinking alcohol, as this will provoke a massive death of brain cells.

When Phezam is used in people suffering from liver diseases, the activity of transaminases (AST, ALT) should be monitored once a week. With an increase in transaminase activity by more than 1.5 times from the upper limit of the norm, Phezam should be discontinued.

Use during pregnancy and lactation

During experiments on animals, the absence of any negative effect of Phezam on the growth and development of the fetus was revealed. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in the mental state of a woman, increased anxiety, lability of the emotional sphere and mood, which theoretically can have a bad effect on the course of pregnancy.

Since Phezam penetrates into milk, it is also contraindicated during breastfeeding. If a woman who is breastfeeding must take Phezam for any reason, then the baby should be transferred to artificial mixtures.

Interaction with other drugs

Taking drugs that dilate blood vessels and reduce pressure leads to an increase in all the effects of Phezam. Accordingly, drugs that narrow blood vessels and increase pressure, on the contrary, weaken the effects of Phezam.

Phezam improves the subjective tolerance of drugs from the group of neuroleptics and antidepressants.

Phezam: before or after meals - how to take

If Phezam needs to be taken several times a day, and full meals are not possible for some reason, then you can just have a snack with something, for example, an apple, a banana, nuts, a bun, a sandwich, etc. instead of lunch, afternoon tea or dinner. A small amount of food that has entered the stomach will completely replace a full meal in terms of minimizing the discomfort from the use of Phezam. Remember that the phrase "after a meal" does not mean that you have to eat a complete lunch, dinner, breakfast or afternoon snack from your point of view. It only means that before taking the drug, you need to eat something, for example, a piece of bread, fruit, a sandwich, a piece of jelly or cold meat from soup, etc.

Phezam children

Phezam is used for therapy in children older than 5 years of age. If necessary, the use of Phezam in children from one year is allowed.

Phezam in children and adolescents normalizes sleep, eliminates nightmares, stops nighttime awakenings, reduces fatigue, improves performance, both mental and physical, and also relieves irritability, emotional instability, mood lability and excessive vulnerability. In addition, Phezam reduces the frequency of headaches in children, improves adaptation in a school or preschool team, stabilizes and maintains normal blood pressure, preventing its jumps. In general, Phezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Phezam is used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist, not a psychiatrist, since it is not suitable for the treatment of severe mental illness, and it can be used successfully for the elimination of mild disorders.

Phezam side effects

Phezam is overwhelmingly well tolerated and rarely causes side effects. According to international standards, all side effects are classified into several groups depending on the frequency of their occurrence. Regarding Phezam, it was found that all side effects are recorded either sometimes or rarely. Moreover, "sometimes", according to the international classification, means that the effect develops in less than one person out of a hundred, but more than 1 out of 1000. And "rarely" means that a side effect develops in more than 1 person out of 10,000 , but less than 1 in 1000. All Phezam side effects are transient, that is, they disappear on their own after the drug is discontinued and do not require any special treatment.

The side effects of Phezam include the following symptoms from various organs and systems:
1. From the side of the central nervous system:

Hyperkinesis (twitching of limbs, excessive movements, etc.);

In this article, you can read the instructions for using the drug Phezam. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Phezam in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Phezam analogues in the presence of existing structural analogues. Use for the treatment of cerebrovascular insufficiency in adults, children, as well as during pregnancy and lactation. Compound.

Phezam- a combined drug with a pronounced antihypoxic, nootropic and vasodilating effect.

Piracetam is a nootropic. It activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission in the central nervous system and regional blood flow in the ischemic zone.

Cinnarizine is a calcium channel blocker. It inhibits the entry of calcium ions into cells and reduces their content in the plasma membrane depot. Reduces the tone of smooth muscles of arterioles, reduces their response to biogenic vasoconstrictor substances (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without significantly affecting blood pressure. Shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, increases the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity.

Compound

Piracetam + cinnarizine + excipients.

Pharmacokinetics

Rapidly and completely absorbed from the gastrointestinal tract. Piracetam does not bind to plasma proteins. Penetrates into all organs and tissues, penetrates through the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia. Cinnarizine is actively and completely metabolized. Piracetam is not metabolized. 1/3 of the metabolites are excreted in the urine, 2/3 - in the feces.

Indications

insufficiency of cerebral circulation (atherosclerosis of the vessels of the brain, the recovery period of ischemic and hemorrhagic strokes, after traumatic brain injuries, encephalopathy of various origins);
intoxication;
diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (impaired memory, attention, mood);
psychoorganic syndrome with a predominance of symptoms of asthenia and adynamia;
asthenic syndrome;
labyrinthopathy;
Meniere's syndrome;
prevention of kinetosis;
migraine prevention;
retardation of intellectual development in children.

Release forms

Capsules 400 mg + 25 mg (sometimes erroneously called tablets, but Phezam tablet forms do not exist).

Instructions for use and dosing regimen

For adults, the drug is prescribed 1-2 capsules 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.

Children over 5 years of age are prescribed 1-2 capsules 1-2 times a day (no more than 3 months).

Side effect

dyspepsia;
headache;
sleep disorders;
allergic reactions in the form of a skin rash.

Contraindications

severe liver dysfunction;
severe renal dysfunction;
parkinsonism;
pregnancy;
lactation (breastfeeding);
children's age up to 5 years;
hypersensitivity to the components of the drug.

Use during pregnancy and lactation

Phezam is contraindicated for use during pregnancy and lactation.

special instructions

In case of mild to moderate renal failure (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses of the drug should be increased.

In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.

Drinking alcohol should be avoided while taking Phezam.

Phezam should be used with caution in patients with elevated intraocular pressure.

The drug can cause a positive reaction in athletes during a doping test, and it is also possible to change the results of the determination of radioactive iodine (the dyes in the capsule shell contain iodine).

Influence on the ability to drive vehicles and control mechanisms

While taking the drug Phezam, patients should be careful when driving vehicles and working with machines and equipment.

drug interaction

With simultaneous use with Phezam, it is possible to increase the sedative effect of drugs that depress the activity of the central nervous system, as well as ethanol (alcohol), nootropic and antihypertensive drugs.

With the simultaneous use of vasodilators enhance the effect of Phezam.

Phezam improves the tolerability of antipsychotic drugs and tricyclic antidepressants.

Phezam's analogues

Structural analogues for the active substance:

Combitropil;
NooKam;
Omaron;
Piracesin.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Phezam is a combined drug, the effectiveness of which is aimed at increasing blood circulation and metabolism in this area. As active ingredients in the composition of the drug is cinnarizine and piracetam.

In this article, we will consider why doctors prescribe Phezam, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Phezam can be read in the comments.

Composition and form of release

Phezam capsules contain two active ingredients - piracetam and cinnarizine.
As additional ingredients in the composition of the product are present: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

Clinico-pharmacological group: a drug that improves blood circulation and brain metabolism.

What helps Phezam?

Among the main indications for the use of the drug are:

depressive states and psychoorganic syndrome;
psychogenic asthenia and labyrinthopathy;
ischemic stroke and other disorders in the field of cerebral circulation;
portal form of hypertension, accompanied by encephalopathy;
underdevelopment of intellectual character in children;
prevention of kinetosis and migraine;
subcomatose and coma after brain injury and intoxication;
damage to the central nervous system, accompanied by a decrease in mnestic and intellectual functions.

Pharmacological properties

The medicine activates the blood circulation of the brain, improves visual and auditory function. The presence of piracetam in the composition enhances energy metabolism, accelerates the reproduction of protein and the breakdown of glucose. The work of cinnarizine is to increase the resistance of cerebral capillaries to hypoxia, vasodilation. In this case, no change in pressure is observed.

The complex effect of active elements allows Phezam tablets to reduce blood viscosity and normalize the functioning of the vestibular apparatus. The drug has slight antihistamine properties, improves the elasticity of erythrocyte membranes.

Instructions for use

According to the instructions for use, Phezam must be taken orally, swallowed whole, without chewing, without violating the integrity of the shell and without pouring the powder into a glass of water. The capsule should be washed down with a small amount of water (at least half a glass) or any other liquid, with the exception of carbonated sugary drinks, coffee and caffeinated energy drinks.

For adults, the drug is prescribed 1-2 caps. 3 times / day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.
Children over 5 years of age are prescribed 1-2 caps. 1-2 times / day. The course of treatment is 1.5-3 months.

Contraindications

There are a number of contraindications for the use of Phezam:

Chorea of Huntington.
Age up to 5 years.
Allergic reactions.
Psychomotor agitation.
Pregnancy and lactation.
Severe renal failure (with creatinine clearance below 20 ml per minute).
Severe liver failure.

Caution should be exercised when used in the following situations: the presence of Parkinson's disease, impaired renal or hepatic function, impaired hemostasis, bleeding.

Side effects

According to reviews Phezam may cause side effects.

Allergic reactions: dermatitis, skin rash, swelling, itching, photosensitivity.
Digestive system: nausea, increased salivation, diarrhea, vomiting, abdominal pain.
Nervous system: nervousness, hyperkinesia, depression, drowsiness, dizziness, ataxia, headaches, insomnia, imbalance, agitation, confusion, hallucinations, anxiety.
Other side effects: increased sexual activity.

Pregnancy and lactation

Despite the lack of data on the presence of teratogenic effects of piracetam and cinnarizine, Phezam is contraindicated for use during pregnancy. Piracetam is excreted in breast milk, so if you need to use the drug during lactation, breastfeeding should be discontinued.

Analogues

Structural analogues for the active substance:

Combitropil;
NooKam;
Omaron;
Piracesin.

Attention: the use of analogues must be agreed with the attending physician.