Thyroxine Triiodothyronine Androgens Glucorticoids

Estrogens

In turn, the release of all 7 of these hormones of the adenohypophysis depends on the hormonal activity of neurons in the hypophysiotropic zone of the hypothalamus - mainly the paraventricular nucleus (PVN). Hormones are formed here that have a stimulating or inhibitory effect on the secretion of hormones of the adenohypophysis. Stimulants are called releasing hormones (liberins), inhibitors are called statins. Thyreoliberin, gonadoliberin are isolated. somatostatin, somatoliberin, prolactostatin, prolactoliberin, melanostatin, melanoliberin, corticoliberin.

Releasing hormones are released from the processes of the nerve cells of the paraventricular nucleus, enter the portal venous system of the hypothalamic-pituitary gland and are delivered with blood to the adenohypophysis.

The regulation of the hormonal activity of most endocrine glands is carried out according to the principle of negative feedback: the hormone itself, its amount in the blood regulates its formation. This effect is mediated through the formation of the corresponding releasing hormones (Fig. 6.7)

In the hypothalamus (supraoptic nucleus), in addition to releasing hormones, vasopressin (antidiuretic hormone, ADH) and oxytocin are synthesized. Which in the form of granules are transported along the nerve processes to the neurohypophysis. The release of hormones by neuroendocrine cells into the bloodstream is due to reflex nerve stimulation.

Rice. 7 Direct and feedback connections in the neuroendocrine system.

1 - slowly developing and prolonged inhibition of the secretion of hormones and neurotransmitters , as well as behavior change and memory formation;

2 - rapidly developing but prolonged inhibition;

3 - short-term inhibition

pituitary hormones

The posterior lobe of the pituitary gland, the neurohypophysis, contains oxytocin and vasopressin (ADH). ADH affects three types of cells:

1) cells of the renal tubules;

2) smooth muscle cells of blood vessels;

3) liver cells.

In the kidneys, it promotes the reabsorption of water, which means its preservation in the body, a decrease in diuresis (hence the name antidiuretic), in blood vessels it causes contraction of smooth muscles, narrowing their radius, and as a result, it increases blood pressure (hence the name "vasopressin"), in liver - stimulates gluconeogenesis and glycogenolysis. In addition, vasopressin has an antinociceptive effect. ADH is designed to regulate the osmotic pressure of the blood. Its secretion increases under the influence of such factors: an increase in blood osmolarity, hypokalemia, hypocalcemia, an increase in the decrease in BCC, a decrease in blood pressure, an increase in body temperature, and activation of the sympathetic system.

With insufficient ADH release, diabetes insipidus develops: the volume of urine excreted per day can reach 20 liters.

Oxytocin in women plays the role of a regulator of uterine activity and is involved in lactation processes as an activator of myoepithelial cells. An increase in the production of oxytocin occurs during the opening of the cervix at the end of pregnancy, ensuring its contraction in childbirth, as well as during the feeding of the child, ensuring the secretion of milk.

The anterior pituitary gland, or adenohypophysis, produces thyroid-stimulating hormone (TSH), somatotropic hormone (GH) or growth hormone, gonadotropic hormones, adrenocorticotropic hormone (ACTH), prolactin, and in the middle lobe - melanocyte-stimulating hormone (MSH) or intermediates.

A growth hormone stimulates protein synthesis in bones, cartilage, muscles and liver. In an immature organism, it provides growth in length by increasing the proliferative and synthetic activity of cartilage cells, especially in the growth zone of long tubular bones, while simultaneously stimulating the growth of the heart, lungs, liver, kidneys and other organs. In adults, it controls the growth of organs and tissues. STH reduces the effects of insulin. Its release into the blood increases during deep sleep, after muscle exertion, with hypoglycemia.

The growth effect of growth hormone is mediated by the effect of the hormone on the liver, where somatomedins (A, B, C) or growth factors are formed that cause the activation of protein synthesis in cells. The value of STH is especially high during the period of growth (prepubertal, pubertal periods).

During this period, GH agonists are sex hormones, an increase in the secretion of which contributes to a sharp acceleration of bone growth. However, the long-term formation of large amounts of sex hormones leads to the opposite effect - to the cessation of growth. An insufficient amount of GH leads to dwarfism (nanism), and an excessive amount leads to gigantism. The growth of some bones in an adult can resume in case of excessive secretion of growth hormone. Then the proliferation of cells of the growth zones resumes. What causes growth

In addition, glucocorticoids inhibit all components of the inflammatory reaction - they reduce capillary permeability, inhibit exudation, and reduce the intensity of phagocytosis.

Glucocorticoids sharply reduce the production of lymphocytes, reduce the activity of T-killers, the intensity of immunological surveillance, hypersensitivity and sensitization of the body. All this allows us to consider glucocorticoids as active immunosuppressants. This property is used in the clinic to stop autoimmune processes, to reduce the host's immune defenses.

Glucocorticoids increase sensitivity to catecholamines, increase the secretion of hydrochloric acid and pepsin. An excess of these hormones causes demineralization of bones, osteoporosis, loss of Ca 2+ in the urine, and reduces the absorption of Ca 2+. Glucocorticoids affect the function of VND - increase the activity of information processing, improve the perception of external signals.

Mineralocorticoids(aldosgeron, deoxycorticosterone) are involved in the regulation of mineral metabolism. The mechanism of action of aldosterone is associated with the activation of protein synthesis involved in the reabsorption of Na + - Na +, K h -ATPase. By increasing reabsorption and reducing it for K + in the distal tubules of the kidney, salivary and gonads, aldosterone contributes to the retention of N "and SG in the body and the excretion of K + and H from the body. Thus, aldosterone is a sodium-sparing, as well as kaliuretic hormone. Due to delay Ia \ and after it water, it helps to increase BCC and, as a result, increase blood pressure.Unlike glucocorticoids, mineralocorticoids contribute to the development of inflammation, because increase capillary permeability.

sex hormones the adrenal glands perform the function of developing the genital organs and the appearance of secondary sexual characteristics at a time when the sex glands are not yet developed, that is, in childhood and in old age.

The hormones of the adrenal medulla - adrenaline (80%) and norepinephrine (20%) - cause effects that are largely identical to the activation of the nervous system. Their action is realized through interaction with a- and (3-adrenergic receptors. Therefore, they are characterized by activation of the activity of the heart, vasoconstriction of the skin, dilation of the bronchi, etc. Adrenaline affects carbohydrate and fat metabolism, enhancing glycogenolysis and lipolysis.

Catecholamines are involved in the activation of thermogenesis, in the regulation of the secretion of many hormones - they increase the release of glucagon, renin, gastrin, parathyroid hormone, calcitonin, thyroid hormones; reduce insulin release. Under the influence of these hormones, the efficiency of skeletal muscles and the excitability of receptors increase.

With hyperfunction of the adrenal cortex in patients, secondary sexual characteristics noticeably change (for example, male sexual characteristics may appear in women - a beard, mustache, voice timbre). Obesity is observed (especially in the area of ​​the neck, face, torso), hyperglycemia, water and sodium retention in the body, etc.

Hypofunction of the adrenal cortex causes Addison's disease - bronze skin tone (especially of the face, neck, hands), loss of appetite, vomiting, increased sensitivity to cold and pain, high susceptibility to infections, increased diuresis (up to 10 liters of urine per day), thirst, decreased performance.

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Hormonal regulation of puberty. Carries out humoral regulation of vital processes In men and women, the function of the gonads is under the control of neurohumoral regulation, which ensures the coordination of neuronal (lat. nervus - nerve) and humoral (lat. humor - liquid) phenomena (the release of certain fluids to nerve stimuli). One of the prerequisites for their functioning is the normal activity of the cerebral appendage (pituitary gland). The secretion and release of hormones into the blood occur under the control of special centers that are located in the hypothalamus. Human sex life also depends on the cerebral cortex. Nervous regulation of sexual function. It is carried out by the sexual centers, which are located in the lumbar and sacral segments of the spinal cord, the hypothalamus and the cerebral cortex. These centers are directly (humorally) and indirectly (by the fibers of the autonomic nervous system) connected to the genitals, endocrine glands and to each other. Before puberty, the main active center of nervous regulation is the spinal cord (sacral segments). With the onset of active functioning of the anterior pituitary gland and hormone-producing cells of the gonads, the remaining nerve centers (lumbar segments of the spinal cord, midbrain and cerebral cortex) turn on. However, if, due to a malfunction, the pituitary gland is unable to produce gonadotropic hormones that stimulate the genital organs, as a result of which more advanced nerve centers begin to function, sexual development does not occur. The regulatory function of the sex centers, which are located in the sacral segments of the spinal cord, is carried out according to the type of unconditioned reflexes; centers in the lumbar segments of the spinal cord and in the midbrain - unconditionally conditional; cortical centers - conditional. Endocrine regulation of sexual function. Specific endocrine regulation of the functions of the genital organs is provided by the pituitary-gonadal system. The pituitary gland secretes gonadotropic hormones, under the influence of which sex hormones are produced in the gonads. The sensitivity of the sexual centers, the development and excitability of the genital organs depend on them. Visual, auditory, olfactory, tactile signals pass through the cerebral cortex and are transformed in the hypothalamus, causing the synthesis of its hormones, which enter the pituitary gland and stimulate the production of other hormones. Hormones are secreted directly into the bloodstream and transported through the bloodstream to the tissues they act on. Testosterone is the most important sex hormone. It is also called the male sex hormone, although women also have it in much smaller quantities. In the body of a healthy man, 6-8 mg of testosterone is produced per day (more than 95% is produced by the testicles, the rest is by the adrenal glands). In the testicles and adrenal glands of a woman, about 0.5 mg of it is produced daily. Testosterone is the main biological factor that determines sexual desire in men and women. An insufficient amount of it leads to a decrease in sexual activity, and an excess of it increases sexual desire. In men, too low testosterone levels can make it difficult to achieve and maintain an erection. in women - causes a decrease in sexual desire. There is no evidence that, in general, women's interest in sex is lower compared to men due to a smaller amount of testosterone in their blood. There is an opinion that the threshold of sensitivity of men AND WOMEN to its action is different, and women are more sensitive to a smaller amount of it in the blood. Estrogens (Greek oistros - passion and genos - birth) (mainly estradiol), which are also called female sex hormones, are also found in men. In women, they are produced in the ovaries, in men - in the testicles. The female body needs them to maintain the normal state of the vaginal mucosa and the production of vaginal secretions. Estrogens also contribute to the preservation of the structure and function of the mammary glands of a woman, her vaginal elasticity. However, they do not significantly affect a woman's interest in sex and her sexual performance, since surgical removal of the ovaries does not reduce women's sexual desire and their sexual activity. The function of estrogen in men is still not well understood. However, their too high level in men sharply reduces sexual activity, can cause difficulty in erection, enlargement of the mammary glands. Both men and women also have progesterone (lat. pro - prefix, means someone who acts in the interests of whom, what, and gestatio - pregnancy) - a hormone that is similar in structure to estrogens and androgens. It is assumed that its high level of inhibition affects the sexual activity of a person, restrains it. So, the neurohumoral regulation of sexual function is provided by the activity of the deep structures of the brain and the endocrine system, which form the expression of sexual desire and excitation of all parts of the nervous system that affect sexual life. Nervous regulation carried out with the help of electrical impulses going through the nerve cells. Compared to humoral going faster more accurate requires a lot of energy more evolutionarily young. Humoral regulation vital processes (from the Latin word humor - “liquid”) is carried out due to substances released into the internal environment of the body (lymph, blood, tissue fluid). Humoral regulation can be carried out with the help of: hormones- biologically active (acting in a very small concentration) substances secreted into the blood by endocrine glands; other substances. For example, carbon dioxide causes local expansion of capillaries, more blood flows to this place; excites the respiratory center of the medulla oblongata, breathing intensifies. All glands of the body are divided into 3 groups 1) Endocrine glands ( endocrine) do not have excretory ducts and secrete their secrets directly into the blood. The secrets of the endocrine glands are called hormones, they have biological activity (act in microscopic concentration). For example: . 2) The glands of external secretion have excretory ducts and secrete their secrets NOT into the blood, but into any cavity or onto the surface of the body. For example, liver, lacrimal, salivary, sweat. 3) Glands of mixed secretion carry out both internal and external secretion. For example iron secretes insulin and glucagon into the blood, and not into the blood (in the duodenum) - pancreatic juice; genital glands secrete sex hormones into the blood, and not into the blood - germ cells. Establish a correspondence between the organ (organ department) involved in the regulation of the life of the human body and the system to which it belongs: 1) nervous, 2) endocrine. A) a bridge B) pituitary gland B) pancreas D) spinal cord D) cerebellum Answer Establish the sequence in which the humoral regulation of respiration is carried out during muscular work in the human body 1) accumulation of carbon dioxide in tissues and blood 2) excitation of the respiratory center in the medulla oblongata 3) impulse transmission to the intercostal muscles and diaphragm 4) strengthening of oxidative processes during active muscular work 5) inhalation and air flow into the lungs Answer Establish a correspondence between the process that occurs during human breathing and the way it is regulated: 1) humoral, 2) nervous A) excitation of nasopharyngeal receptors by dust particles B) slowing down breathing when immersed in cold water C) a change in the rhythm of breathing with an excess of carbon dioxide in the room D) respiratory failure when coughing D) a change in the rhythm of breathing with a decrease in the content of carbon dioxide in the blood Answer 1. Establish a correspondence between the characteristics of the gland and the type to which it belongs: 1) internal secretion, 2) external secretion. Write the numbers 1 and 2 in the correct order. A) have excretory ducts B) produce hormones C) provide regulation of all vital functions of the body D) secrete enzymes into the stomach D) excretory ducts go to the surface of the body E) the substances produced are released into the blood Answer 2. Establish a correspondence between the characteristics of the glands and their type: 1) external secretion, 2) internal secretion. Write the numbers 1 and 2 in the correct order. A) produce digestive enzymes B) secrete into the body cavity B) secrete chemically active substances - hormones D) participate in the regulation of the vital processes of the body D) have excretory ducts Answer Establish a correspondence between the glands and their types: 1) external secretion, 2) internal secretion. Write the numbers 1 and 2 in the correct order. A) epiphysis B) pituitary gland B) adrenal gland D) salivary D) liver E) cells of the pancreas that produce trypsin Answer Establish a correspondence between an example of the regulation of the work of the heart and the type of regulation: 1) humoral, 2) nervous A) increased heart rate under the influence of adrenaline B) changes in the work of the heart under the influence of potassium ions C) changes in heart rate under the influence of the autonomic system D) weakening of the activity of the heart under the influence of the parasympathetic system Answer Establish a correspondence between the gland in the human body and its type: 1) internal secretion, 2) external secretion A) dairy B) thyroid B) liver D) sweat D) pituitary gland E) adrenal glands Answer 1. Establish a correspondence between the sign of the regulation of functions in the human body and its type: 1) nervous, 2) humoral. Write the numbers 1 and 2 in the correct order. A) is delivered to the organs by blood B) high speed of response B) is more ancient D) is carried out with the help of hormones D) is associated with the activity of the endocrine system Answer 2. Establish a correspondence between the characteristics and types of regulation of body functions: 1) nervous, 2) humoral. Write down the numbers 1 and 2 in the order corresponding to the letters. A) turns on slowly and lasts a long time B) the signal propagates along the structures of the reflex arc B) is carried out by the action of a hormone D) the signal propagates with the bloodstream D) turns on quickly and acts briefly E) evolutionarily older regulation Answer Choose one, the most correct option. Which of the following glands secrete their products through special ducts into the cavities of the organs of the body and directly into the blood 1) sebaceous 2) sweat 3) adrenal glands 4) sexual Answer Establish a correspondence between the gland of the human body and the type to which it belongs: 1) internal secretion, 2) mixed secretion, 3) external secretion A) pancreas B) thyroid B) lacrimal D) sebaceous D) sexual E) adrenal gland Answer Choose three options. In what cases is humoral regulation carried out? 1) excess carbon dioxide in the blood 2) the body's reaction to a green traffic light 3) excess glucose in the blood 4) the reaction of the body to a change in the position of the body in space 5) release of adrenaline during stress Answer Establish a correspondence between examples and types of respiratory regulation in humans: 1) reflex, 2) humoral. Write down the numbers 1 and 2 in the order corresponding to the letters. A) stop breathing on inspiration when entering cold water B) an increase in the depth of breathing due to an increase in the concentration of carbon dioxide in the blood C) cough when food enters the larynx D) a slight delay in breathing due to a decrease in the concentration of carbon dioxide in the blood D) change in the intensity of breathing depending on the emotional state E) spasm of cerebral vessels due to a sharp increase in the concentration of oxygen in the blood Answer Choose three endocrine glands. 1) pituitary gland 2) sexual 3) adrenal glands 4) thyroid 5) gastric 6) dairy Answer Choose three options. Humoral effects on physiological processes in the human body 1) carried out with the help of chemically active substances 2) associated with the activity of the glands of external secretion 3) spread more slowly than nerve 4) occur with the help of nerve impulses 5) are controlled by the medulla oblongata 6) carried out through the circulatory system Answer Choose three correct answers from six and write down the numbers under which they are indicated. What is characteristic of the humoral regulation of the human body? 1) the response is clearly localized 2) a hormone serves as a signal 3) turns on quickly and acts instantly 4) signal transmission is only chemical through body fluids 5) signal transmission is carried out through the synapse 6) the response is valid for a long time Answer © D.V. Pozdnyakov, 2009-2019 Anatomical and physiological features of puberty and the tasks of hygiene education Anatomical and physiological features of brain maturation. psychophysical aspects of the child's behavior The chromosome sets of the male and female body differ in that women have two X chromosomes, while men have one X and one Y chromosome. This difference determines the sex of the embryo and occurs at the time of fertilization. Already in the embryonic period, the development of the sexual sphere is completely dependent on the activity of hormones. The activity of the sex chromosomes is observed in a very short period of ontogenesis - from the 4th to the 6th week of intrauterine development and is manifested only in the activation of the testes. There are no differences in the differentiation of other body tissues between boys and girls, and if it were not for the hormonal influence of the testes, development would proceed only according to the female type. The female pituitary gland works cyclically, which is determined by hypothalamic influences. In men, the pituitary gland functions evenly. It has been established that there are no sex differences in the pituitary itself, they are contained in the nervous tissue of the hypothalamus and adjacent nuclei of the brain. Between the 8th and 12th week of intrauterine development, the testis must “form” the hypothalamus in a male pattern with the help of androgens. If this does not happen, the fetus will retain the cyclic type of secretion of gonadotropins even in the presence of the male set of XY chromosomes. Therefore, the use of sex steroids by a pregnant woman in the early stages of pregnancy is very dangerous. Boys are born with well-developed testicular excretory cells (Leydig cells), which, however, degrade in the 2nd week after birth. Again, they begin to develop only during puberty. This and some other facts suggest that the human reproductive system is, in principle, ready for development already at the time of birth, however, under the influence of specific neurohumoral factors, this process slows down for several years - before the onset of pubertal changes in the body. In newborn girls, a reaction from the uterus is sometimes observed, bloody discharge appears like menstruation, and there is also activity of the mammary glands up to the secretion of milk. A similar reaction of the mammary glands occurs in newborn boys. In the blood of newborn boys, the content of the male hormone testosterone is higher than in girls, but already a week after birth, this hormone is almost not found in either boys or girls. However, a month later, in boys, the content of testosterone in the blood again rapidly increases, reaching by 4-7 months. half the level of an adult male, and remains at this level for 2-3 months, after which it decreases slightly and no longer changes until the onset of puberty. What is the reason for such an infantile release of testosterone is unknown, but there is an assumption that some very important “male” properties are formed during this period. The process of puberty proceeds unevenly, and it is customary to subdivide it into certain stages, at each of which specific relationships are formed between the systems of nervous and endocrine regulation. The English anthropologist J. Tanner called these stages stages, and the studies of domestic and foreign physiologists and endocrinologists made it possible to establish what morphological and functional properties are characteristic of the organism at each of these stages. Zero stage- neonatal stage. This stage is characterized by the presence of preserved maternal hormones in the child's body, as well as a gradual regression of the activity of its own endocrine glands after the birth stress is over. First stage stage of childhood (infantilism). The period from one year to the appearance of the first signs of puberty is regarded as the stage of sexual infantilism, that is, it is understood that nothing happens during this period. However, a slight and gradual increase in the secretion of pituitary and gonadal hormones during this period takes place, and this indirectly indicates the maturation of the diencephalic structures of the brain. The development of the gonads during this period does not occur because it is inhibited by a gonadotropin-inhibiting factor, which is produced by the pituitary gland under the influence of the hypothalamus and another brain gland - the pineal gland. From the age of 3, girls are ahead of boys in terms of physical development, and this is combined with a higher content of growth hormone in their blood. Immediately before puberty, the secretion of growth hormone is further enhanced, and this causes an acceleration of growth processes - the prepubertal growth spurt. The external and internal genital organs develop inconspicuously, there are no secondary sexual characteristics. This stage ends in girls at 8-10 years old, and in boys - at 10-13 years old. Although boys grow slightly slower than girls at this stage, the longer duration of the stage results in boys being larger than girls when they enter puberty. Second stage- pituitary (beginning of puberty). By the beginning of puberty, the formation of a gonadotropin inhibitor decreases, and the pituitary secretion of the two most important gonadotropic hormones that stimulate the development of the sex glands, follitropin and lutropin, also increases. As a result, the glands "wake up" and the active synthesis of testosterone begins. At this moment, the sensitivity of the sex glands to pituitary influences increases significantly, and effective feedbacks are gradually established in the hypothalamus-pituitary-gonads system. In girls in the same period, the concentration of growth hormone is highest, in boys the peak of growth activity is observed later. The first external sign of the beginning of puberty in boys is an increase in the testicles, which just happens under the influence of gonadotropic hormones of the pituitary gland. At the age of 10, these changes can be seen in a third of boys, at 11 - in two-thirds, and by the age of 12 - in almost all. In girls, the first sign of puberty is swelling of the mammary glands, and often the enlargement of the left gland begins a little earlier. At first, the glandular tissue can only be palpated, then the areola protrudes. The deposition of adipose tissue and the formation of a mature gland occurs at subsequent stages of puberty. This stage of puberty ends in boys at 11-12 years old, and in girls at 9-10 years old. Third stage- stage of gonadal activation. At this stage, the effect of pituitary hormones on the sex glands increases, and the gonads begin to produce large amounts of sex steroid hormones. At the same time, the gonads themselves also increase: in boys, this is clearly noticeable by a significant increase in the size of the testicles. In addition, under the total influence of growth hormone and androgens, boys are greatly elongated in length, the penis also grows, almost reaching adult size by the age of 15. A high concentration of female sex hormones - estrogens - in boys during this period can lead to swelling of the mammary glands, expansion and increased pigmentation of the nipple and areola zone. These changes are short-lived and usually disappear without intervention within a few months after the onset. At this stage, both boys and girls experience intense pubic and axillary hair growth. This stage ends in girls at 10-11, and in boys at 12-16 years. Fourth stage stage of maximum steroidogenesis. The activity of the gonads reaches a maximum, the adrenal glands synthesize a large amount of sex steroids. Boys maintain a high level of growth hormone, so they continue to grow rapidly, in girls, growth processes slow down. Primary and secondary sexual characteristics continue to develop: pubic and axillary hair growth increases, the size of the genitals increases. In boys, it is at this stage that a mutation (breaking) of the voice occurs. Fifth stage- stage of final formation. Physiologically, this period is characterized by the establishment of a balanced feedback between the hormones of the pituitary gland and peripheral glands. This stage begins in girls at 11-13 years old, in boys - at 15-17 years old. Ticket 1. 1. Factors of nonspecific resistance of the organism Nonspecific protection factors are congenital, have specific features, are inherited. Animals with reduced resistance do not adapt well to any changes in the environment and are susceptible to both infectious and non-infectious diseases. The following factors protect the body from any foreign agent. Histohematic barriers are barriers formed by a series of biological membranes between blood and tissues. These include: the blood-brain barrier (between the blood and the brain), hematothymic (between the blood and thymus), placental (between the mother and the fetus), etc. They protect the organs from those agents that nevertheless penetrated into the blood through the skin or mucous membranes. Phagocytosis is the process of absorption of foreign particles by cells and their digestion. Phagocytes include microphages and macrophages. Microphages are granulocytes, the most active phagocytes are neutrophils. Light and mobile, neutrophils are the first to rush towards the stimulus, absorb and break down foreign particles with their enzymes, regardless of their origin and properties. Eosinophils and basophils have weakly expressed phagocytic activity. Macrophages include blood monocytes and tissue macrophages - wandering or fixed in certain areas. Phagocytosis proceeds in 5 phases. 1. Positive chemotaxis - active movement of phagocytes towards chemical stimuli. 2. Adhesion - adhesion of a foreign particle to the surface of a phagocyte. There is a rearrangement of receptor molecules, they approach and concentrate, then the contractile mechanisms of the cytoskeleton are launched, and the phagocyte membrane seems to float on the object. 3. The formation of a phagosome - the retraction of a particle surrounded by a membrane into the phagocyte. 4. Formation of a phagolysosome - the fusion of a lysosome of a phagocyte with a phagosome. Digestion of a foreign particle, that is, its enzymatic cleavage 5. Removing unnecessary products from the cage. Lysozyme is an enzyme that hydrolyzes the glycosidic bonds of polyamino sugars in the shells of many m / o. The result of this is damage to the membrane structure and the formation of defects (large pores) in it, through which water penetrates into the microbial cell and causes its lysis. Lysozyme is synthesized by neutrophils and monocytes, it is found in blood serum, in the secrets of exocrine glands. Very high concentration of lysozyme in saliva, especially in dogs, and in lacrimal fluid. V-lysines. These are enzymes that activate the dissolution of cell membranes, including m / o, by their own enzymes. B-lysins are formed during the destruction of platelets during blood clotting, they are found in high concentrations in the blood serum. complement system. It includes: complement, properdin and magnesium ions. Properdin is a protein complex with antimicrobial and antiviral activity, but it does not act in isolation, but in combination with magnesium and complement, activating and enhancing its action. Complement (“addition”) is a group of blood proteins that have enzymatic activity and interact with each other in a cascade reaction, that is, the first activated enzymes activate the enzymes of the next row by splitting them into fragments, these fragments also have enzymatic activity, therefore the number of participants in the reaction avalanche-like (cascade) increases. Complement components are denoted by the Latin letter C and serial numbers - C1, C2, C3, etc. Complement components are synthesized by tissue macrophages in the liver, skin, intestinal mucosa, as well as vascular endothelium, neutrophils. They are constantly in the blood, but in an inactive state, and their content does not depend on the introduction of the antigen. Activation of the complement system can be carried out in two ways - classical and alternative. The classical way of activation of the first component of the system (C1) requires the obligatory presence of AG+AT immune complexes in the blood. This is a fast and efficient way. An alternative activation pathway occurs in the absence of immune complexes, then the surfaces of cells and bacteria become the activator. Starting with the activation of the C3 component, a common path of subsequent reactions is launched, which ends with the formation of a membrane attack complex - a group of enzymes that provide lysis (dissolution) of the object of enzymatic attack. The activation of C3, a key component of complement, involves properdin and magnesium ions. The C3 protein binds to the microbial cell membrane. M / o, carrying activated SZ on the surface, are easily absorbed and destroyed by phagocytes. In addition, the released complement fragments attract other participants - neutrophils, basophils and mast cells - to the reaction site. The value of the complement system: 1 - enhances the connection of AG + AT, adhesion and phagocytic activity of phagocytes, that is, it contributes to the opsonization of cells, prepares them for subsequent lysis; 2 - promotes the dissolution (lysis) of immune complexes and their removal from the body; 3 - participates in inflammatory processes (release of histamine from mast cells, local hyperemia, increased vascular permeability), in blood coagulation processes (destruction of platelets and release of platelet coagulation factors). Interferons are substances of antiviral protection. They are synthesized by some lymphocytes, fibroblasts, connective tissue cells. Interferons do not destroy viruses, but, being formed in infected cells, they bind to receptors of nearby, healthy cells. Further, intracellular enzyme systems are switched on, blocking the synthesis of proteins and own cells, and viruses => the focus of infection is localized and does not spread to healthy tissue. Thus, nonspecific resistance factors are constantly present in the body, they act independently of the specific properties of antigens, they do not increase when the body comes into contact with foreign cells or substances. This is a primitive, ancient way of protecting the body from foreign substances. It is not "remembered" by the body. Although many of these factors are also involved in the body's immune response, the mechanisms of complement or phagocyte activation are nonspecific. Thus, the mechanism of phagocytosis is nonspecific, it does not depend on the individual properties of the agent, but is carried out against any foreign particle. So is lysozyme: its physiological significance lies in the regulation of the permeability of body cells by destroying the polysaccharide complexes of cell membranes, and not in response to microbes. In the system of preventive measures in veterinary medicine, an important place is occupied by measures to increase the natural resistance of animals. They include a proper, balanced diet, a sufficient amount of proteins, lipids, minerals and vitamins in the feed. Of great importance in the maintenance of animals is given to solar insolation, dosed physical activity, ensuring good sanitary conditions, and relieving stressful situations. 2. Functional characteristics of the female reproductive system. Terms of sexual and physiological maturity of females. Follicular development, ovulation and formation of the corpus luteum. The sexual cycle and the factors that cause it. 72 Female germ cells are formed in the ovaries, here the hormones necessary for the implementation of reproductive processes are synthesized. By the time of puberty, females have a large number of developing follicles in the cortical layer of the ovaries. The development of follicles and eggs is a cyclical process. At the same time, one or more follicles and, accordingly, one or more eggs develop. Follicle development stages: The primary follicle consists of a germ cell (oocyte of the first order), a single layer of follicular cells surrounding it and a connective tissue membrane - theca; The secondary follicle is formed as a result of the reproduction of follicular cells, which at this stage surround the germ cell in several layers; Graaffian vesicle - in the center of such a follicle there is a cavity filled with liquid, surrounded by a zone of follicular cells located in 10-12 layers. Of the growing follicles, only a part develops completely. Most of them die at different stages of development. This phenomenon is called follicular atresia. This process is a physiological phenomenon necessary for the normal course of cyclic processes in the ovaries. After maturation, the wall of the follicle breaks, and the egg in it, together with the follicular fluid, enters the funnel of the oviduct. The process of releasing an egg from a follicle is called ovulation. It is currently believed that ovulation is associated with certain biochemical and enzymatic processes in the wall of the follicle. Before ovulation, the amount of hyaluronidase and proteolytic enzymes in the follicle increases, which are significantly involved in the lysis of the follicle membrane. Synthesis of hyaluronidase occurs under the influence of LH. After ovulation, the egg enters the oviduct through the funnel of the oviduct. There are reflex and spontaneous ovulation. reflex ovulation characteristic of cats and rabbits. In these animals, the rupture of the follicle and the release of the egg occurs only after sexual intercourse (or less often, after strong sexual arousal). Spontaneous ovulation does not require sexual intercourse, the rupture of the follicle occurs when it reaches a certain degree of maturity. Spontaneous ovulation is typical for cows, goats, mares, dogs. After the release of the egg with cells of the radiant crown, the cavity of the follicles is filled with blood from ruptured vessels. The cells of the follicle shell begin to multiply and gradually replace the blood clot, forming the corpus luteum. There are cyclic corpus luteum and corpus luteum of pregnancy. The corpus luteum is a temporary endocrine gland. Its cells secrete progesterone, as well as (especially, but in the second half of pregnancy) relaxin. sexual cycle The sexual cycle should be understood as a set of structural and functional changes that occur in the reproductive apparatus and the entire body of the female from one ovulation to another. The period of time from one ovulation (hunt) to another is the duration of the sexual cycle. Animals in which sexual cycles (in the absence of pregnancy) are repeated frequently during the year are called polycyclic (cows, pigs). Monocyclic animals are those in which the sexual cycle is observed only once or twice during the year (for example, cats, foxes). Sheep are an example of polycyclic animals with a pronounced sexual season, they have several sexual cycles one after another, after which the cycle is absent for a long time. The English researcher Hipp, on the basis of morphofunctional changes occurring in the female genital apparatus, identified the following stages of the sexual cycle: - proestrus (forerunner)- the beginning of the rapid growth of follicles. Developing follicles produce estrogens. Under their influence, it increased the blood supply to the genital organs, the vaginal mucosa acquires a reddish color as a result. There is keratinization of its cells. The secretion of mucus by the cells of the mucous membrane of the vagina and cervix increases. The uterus increases, its mucous membrane becomes filled with blood and the uterine glands become active. In females, bleeding from the vagina is observed at this time. - Estrus (estrus)- sexual arousal occupies a dominant position. The animal tends to mate and allows cage. The blood supply to the genital apparatus and the secretion of mucus are enhanced. The cervical canal relaxes, which leads to the flow of mucus from it (hence the name - "estrus"). The growth of the follicle is completed and ovulation occurs - its rupture and release of the egg. - Metestrus (post-estrus)- epithelial cells of the opened follicle turn into luteal cells, yellow body. The blood vessels in the wall of the uterus grow, the activity of the uterine glands increases. The cervical canal is closed. Reduced blood flow to the external genitalia. Sexual hunting stops. - Diestrus - the last stage of the sexual cycle. dominance of the corpus luteum. The uterine glands are active, the cervix is ​​closed. There is little cervical mucus. The mucous membrane of the vagina is pale. - Anestrus - a long period of sexual rest, during which the function of the ovaries is weakened. It is typical for monocyclic animals and for animals with a pronounced sexual season between cycles. The development of follicles during this period does not occur. The uterus is small and anemic, its cervix is ​​tightly closed. The mucous membrane of the vagina is pale. The Russian scientist Studentsov proposed another classification of the stages of the sexual cycle, reflecting the characteristics of the state of the nervous system and behavioral reactions of females. According to the views of Studentsov, the sexual cycle is a manifestation of the vital activity of the whole organism as a whole, and not just the reproductive system. This process includes the following steps: - arousal stage characterized by the presence of four phenomena: estrus, sexual (general) arousal of the female, hunting and ovulation. Excitation stage begins with the maturation of the follicle. The process of ovulation completes the stage of arousal. Ovulation in mares, sheep and pigs occurs a few hours after the start of the hunt, and in cows (unlike females of other species) 11-26 hours after the extinction of the immobility reflex. You can count on successful insemination of the female only during the stage of excitation. - braking stage- during this period, there is a weakening and complete cessation of estrus and sexual arousal. In the reproductive system, involutional processes predominate. The female no longer reacts to the male or other females in the hunt (reactivity), in place of the ovulated follicles, corpus luteum begins to develop, which secrete the pregnancy hormone progesterone. If fertilization does not occur, then the processes of proliferation and secretion, which began during estrus, gradually stop. - balancing stage- during this period of the sexual cycle, there are no signs of estrus, hunting and sexual arousal. This stage is characterized by a balanced state of the animal, the presence of corpus luteum and follicles in the ovary. Approximately two weeks after ovulation, the secretory activity of the corpus luteum ceases in the absence of pregnancy. The processes of maturation of the follicles are activated again and a new sexual cycle begins. Neuro-humoral regulation of female sexual functions The excitation of sexual processes occurs through the nervous system and its higher department - the cerebral cortex. There are signals about the action of external and internal stimuli. From there, the impulses enter the hypothalamus, the neurosecretory cells of which secrete specific neurosecrets (releasing factors). The latter act on the pituitary gland, which as a result releases gonadotropic hormones: FSH, LH and LTH. The intake of FSH into the blood causes the growth, development and maturation of follicles in the ovaries. The maturing follicles produce follicular (estrogenic) hormones that cause estrus in animals. The most active estrogen is estradiol. Under the influence of estrogen, the uterus enlarges, the epithelium of its mucous membrane expands, swells, and the secretion of all sex glands increases. Estrogens stimulate contractions of the uterus and fallopian tubes, increasing their sensitivity to oxytocin, breast development, and metabolism. As estrogen accumulates, their effect on the nervous system increases, which causes sexual arousal and hunting in animals. Estrogens in large quantities act on the pituitary-hypothalamus system (by the type of negative connection), as a result of which the secretion of FSH is inhibited, but at the same time, the release of LH and LTH is enhanced. Under the influence of LH in combination with FSH, ovulation occurs and the formation of the corpus luteum, the function of which is supported by LH. The resulting corpus luteum produces the hormone progesterone, which determines the secretory function of the endometrium and prepares the uterine mucosa for implantation of the embryo. Progesterone contributes to the preservation of variability in animals at the initial stage, inhibits the growth of follicles and ovulation, and prevents uterine contraction. A high concentration of progesterone (by the principle of a negative relationship) inhibits the further release of LH, while stimulating (by the type of positive relationship) the secretion of FSH, resulting in the formation of new follicles and the sexual cycle is repeated. For the normal manifestation of sexual processes, hormones of the epiphysis, adrenal glands, thyroid and other glands are also necessary. 3. Skin analyzer 109 RECEIVING APPARATUS: four types of reception in the skin - thermal, cold, tactile, pain. CONDUCTION PATH: segmental afferent nerves - spinal cord - medulla oblongata - thalamus - subcortical nuclei - cortex. CENTRAL PART: cerebral cortex (coincides with motor areas). Temperature reception . Krause flasks perceive low temperature, papillary Ruffini's brushes , Golgi-Mazzoni bodies - high. Cold receptors are located more superficially. Tactile reception. Taurus Vater-Pacini, Merkel, Meissner - perceive touch and pressure (touch). Pain reception. Free nerve endings. They do not have an adequate stimulus: a sensation of pain occurs with any kind of stimulus, if it is strong enough or causes a metabolic disorder in the skin and the accumulation of metabolic products in it (histamine, serotonin, etc.). The skin analyzer has high sensitivity (the horse distinguishes touch at different points of the skin at a very small distance; the difference in temperature can be determined at 0.2 ° C), contrast , adaptation (animals do not feel harness, collar). Ticket 3. 1. Physiological characteristics of water-soluble vitamins. Water-soluble vitamins - C, P, vitamins of group B. Sources of water-soluble vitamins: green fodder, germinated grain, shells and germs of seeds, cereals, legumes, yeast, potatoes, needles, milk and colostrum, eggs, liver. Most water-soluble vitamins in the body of farm animals are synthesized by the microflora of the gastrointestinal tract. VITAMIN C- ascorbic acid, antiscorbutic vitamin. Meaning: factor of nonspecific resistance of the body (stimulation of immunity); participation in the metabolism of proteins (especially collagen) and carbohydrates, in oxidative processes, in hematopoiesis. regulation of capillary permeability. With hypovitaminosis C: scurvy - bleeding and fragility of capillaries, tooth loss, violation of all metabolic processes. VITAMIN R- citrine. Meaning: acts together with vitamin C, regulates capillary permeability and metabolism. VITAMIN B₁- thiamine, an anti-neuritic vitamin. Meaning: is part of the enzymes that decarboxylate keto acids; a particularly important function of thiamine is metabolism in the nervous tissue, and in the synthesis of acetylcholine. With hypovitaminosis B₁ dysfunction of nerve cells and nerve fibers (polyneuritis), exhaustion, muscle weakness. VITAMIN B 2- riboflavin. Meaning Keywords: metabolism of carbohydrates, proteins, oxidative processes, functioning of the nervous system, gonads. Hypovitaminosis- in birds, pigs, less often - horses. Growth retardation, weakness, paralysis. VITAMIN B₃- pantothenic acid. Meaning: component of co-enzyme A (CoA). Participates in fat metabolism, carbohydrate, protein. Activates acetic acid. Hypovitaminosis- chickens, piglets. Growth retardation, dermatitis, disorder of coordination of movements. VITAMIN B4- choline. Meaning: are part of lecithins, are involved in fat metabolism, in the synthesis of acetylcholine. With hypovitaminosis- fatty degeneration of the liver. VITAMIN B 5- PP, nicotinic acid, anti-pellagric . Meaning: is part of the coenzyme of dehydrogenases, which catalyze OVR. Stimulates the secretion of pschvr juices, the work of the heart, hematopoiesis. Hypovitaminosis- in pigs and birds: dermatitis, diarrhea, dysfunction of the cerebral cortex - pellagra. VITAMIN B 6- pyridoxine - adermin. Meaning: participation in protein metabolism - transamination, decarboxylation of AMK. Hypovitaminosis- in pigs, calves, birds: dermatitis, convulsions, paralysis. VITAMIN B₉- folic acid. Meaning: participation in hematopoiesis (together with vitamin B 12), in fat and protein metabolism. With hypovitaminosis- anemia, growth retardation, fatty liver. VITAMIN H- biotin, anti-seborrheic vitamin . Meaning: participation in carboxylation reactions. Hypovitaminosis biotin: dermatitis, profuse sebum secretion (seborrhea). VITAMIN B 12- cyanocobalamin. Meaning: erythropoiesis, synthesis of hemoglobin, NK, methionine, choline; stimulates protein metabolism. Hypovitaminosis- in pigs, dogs, birds: impaired hematopoiesis and anemia, disorder of protein metabolism, accumulation of residual nitrogen in the blood. VITAMIN B 15- pangamic acid. Meaning: increased OVR, prevention of fatty infiltration of the liver. PABC- para-aminobenzoic acid. Meaning: part of vitamin B c - folic acid. ANTIVITAMINS- substances similar in chemical composition to vitamins, but having the opposite, antagonistic effect and competing with vitamins in biological processes. 2. Bile formation and bile secretion. The composition of bile and its importance in the process of digestion. Regulation of bile secretion The formation of bile in the liver goes on continuously. In the gallbladder, some salts and water are reabsorbed from the bile, as a result of which a thicker, more concentrated, so-called gallbladder bile (pH 6.8) is formed from the hepatic bile (pH 7.5). It consists of mucus secreted by the cells of the mucous membrane of the gallbladder. The composition of bile: inorganic substances - sodium, potassium, calcium, bicarbonate, phosphate, water; organic matter - bile acids (glycocholic, taurocholic, lithocholic), bile pigments (bilirubin, biliverdin), fats, fatty acids, phospholipids, cholesterol, amino acids, urea. There are no enzymes in bile! Regulation of bile excretion- complex reflex and neurohumoral. parasympathetic nerves- contraction of the smooth muscles of the gallbladder and relaxation of the sphincter of the bile duct, as a result - excretion of bile. Sympathetic nerves - contraction of the sphincter of the bile duct and relaxation of the muscles of the gallbladder. Accumulation of bile in the gallbladder. Stimulates bile excretion- food intake, especially fatty food, irritation of the vagus nerve, cholecystokinin, secretin, acetylcholine, bile itself. The value of bile: emulsification of fats, enhancing the action of digestive enzymes, the formation of water-soluble complexes of bile acids with fatty acids and their absorption; increased intestinal motility; excretory function (bile pigments, cholesterol, salts of heavy metals); disinfection and deodorization, neutralization of hydrochloric acid, activation of prosecretin. 3. Transfer of excitation from the nerve to the working organ. Synapses and their properties. Mediators and their role 87 The point of contact of an axon with another cell - nerve or muscle - is called synapse. The membrane that covers the end of an axon is called presynaptic. The part of the membrane of the second cell, located opposite the axon, is called postsynaptic. Between them - synaptic cleft. In neuromuscular synapses, to transfer excitation from an axon to a muscle fiber, chemicals are used - mediators (mediators) - acetylcholine, norepinephrine, adrenaline, etc. In each synapse, one mediator is produced, and synapses are called by the name of the mediator cholinergic or adrenergic. The presynaptic membrane contains vesicles in which mediator molecules accumulate. on the postsynaptic membrane there are molecular complexes called receptors(do not confuse with receptors - sensitive nerve endings). The structure of the receptor includes molecules that “recognize” the mediator molecule and an ion channel. There is also a high-energy substance - ATP, and the enzyme ATP-ase, which stimulates the breakdown of ATP for energy supply of excitation. After performing its function, the mediator must be destroyed, and hydrolytic enzymes are built into the postsynaptic membrane: acetylcholinesterase, or cholinesterase, which destroys acetylcholine and monoamine oxidase, which destroys norepinephrine. 2. The hypothalamic-pituitary system as the main mechanism of neurohumoral regulation of hormone secretion. 3. Pituitary hormones 5. Parathyroid hormones 6. Pancreatic hormones 7. The role of hormones in the adaptation of the body under the action of stress factors Humoral regulation- this is a kind of biological regulation in which information is transmitted with the help of biologically active substances that are carried throughout the body by blood, lymph, intercellular fluid. Humoral regulation differs from nervous regulation: the carrier of information is a chemical substance (in the case of a nervous one, a nerve impulse, PD); the transfer of information is carried out by the flow of blood, lymph, by diffusion (in the case of the nervous - by nerve fibers); the humoral signal propagates more slowly (with blood flow in the capillaries - 0.05 mm/s) than the nervous one (up to 120-130 m/s); the humoral signal does not have such an exact "addressee" (nervous - very specific and accurate), the impact on those organs that have receptors for the hormone. Factors of humoral regulation: "classic" hormones Hormones APUD system Classic, actually hormones are substances synthesized by the endocrine glands. These are the hormones of the pituitary gland, hypothalamus, pineal gland, adrenal glands; pancreas, thyroid, parathyroid, thymus, gonads, placenta (Fig. I). In addition to the endocrine glands, in various organs and tissues there are specialized cells that secrete substances that act on target cells by diffusion, i.e., acting locally. These are paracrine hormones. These include hypothalamic neurons that produce certain hormones and neuropeptides, as well as cells of the APUD system, or systems for capturing amine precursors and decarboxylation. An example is: liberins, statins, neuropeptides of the hypothalamus; interstitial hormones, components of the renin-angiotensin system. 2) tissue hormones secreted by non-specialized cells of various types: prostaglandins, enkephalins, components of the kallikrein-inin system, histamine, serotonin. 3) metabolic factors- these are non-specific products that are formed in all cells of the body: lactic, pyruvic acids, CO 2, adenosine, etc., as well as decay products during intense metabolism: increased content of K +, Ca 2+, Na +, etc. The functional significance of hormones: 1) ensuring growth, physical, sexual, intellectual development; 2) participation in the adaptation of the organism in various changing conditions of the external and internal environment; 3) maintaining homeostasis.. Rice. 1 Endocrine glands and their hormones Properties of hormones: 1) specificity of action; 2) the distant nature of the action; 3) high biological activity. 1. The specificity of action is ensured by the fact that hormones interact with specific receptors located in certain target organs. As a result, each hormone acts only on specific physiological systems or organs. 2. The distance lies in the fact that the target organs on which hormones act, as a rule, are located far from the place of their formation in the endocrine glands. Unlike "classical" hormones, tissue hormones act paracrine, that is, locally, not far from the place of their formation. Hormones act in very small amounts, which is how they manifest themselves. high biological activity. So, the daily requirement for an adult is: thyroid hormones - 0.3 mg, insulin - 1.5 mg, androgens - 5 mg, estrogen - 0.25 mg, etc. The mechanism of action of hormones depends on their structure. Hormones of protein structure Hormones of steroid structure Rice. 2 Mechanism of hormonal control Protein structure hormones (Fig. 2) interact with the receptors of the plasma membrane of the cell, which are glycoproteins, and the specificity of the receptor is due to the carbohydrate component. The result of the interaction is the activation of protein phosphokinases, which provide phosphorylation of regulatory proteins, transfer of phosphate groups from ATP to hydroxyl groups of serine, threonine, tyrosine, protein. The end effect of these hormones can be - reduction, enhancement of enzymatic processes, for example, glycogenolysis, increased protein synthesis, increased secretion, etc. The signal from the receptor, with which the protein hormone has interacted, to the protein kinase is transmitted with the participation of a specific mediator or second messenger. Such messengers can be (Fig. 3): 1) cAMP; 2) Ca 2+ ions; 3) diacylglycerol and inositol triphosphate; 4) other factors. Fig.Z. The mechanism of membrane reception of the hormonal signal in the cell with the participation of secondary messengers. Steroid hormones (Fig. 2) easily penetrate the cell through the plasma membrane due to their lipophilicity and interact in the cytosol with specific receptors, forming a “hormone-receptor” complex that moves to the nucleus. In the nucleus, the complex breaks down and hormones interact with nuclear chromatin. As a result of this, interaction with DNA occurs, and then - the induction of messenger RNA. Due to the activation of transcription and translation, after 2-3 hours, after exposure to the steroid, an increased synthesis of induced proteins is observed. In one cell, the steroid affects the synthesis of no more than 5-7 proteins. It is also known that in the same cell, a steroid hormone can induce the synthesis of one protein and repress the synthesis of another protein (Fig. 4). The action of thyroid hormones is carried out through the receptors of the cytoplasm and nucleus, as a result of which the synthesis of 10-12 proteins is induced. Reflation of hormone secretion is carried out by such mechanisms: 1) direct effect of blood substrate concentrations on gland cells; 2) nervous regulation; 3) humoral regulation; 4) neurohumoral regulation (hypothalamic-pituitary system). In the regulation of the activity of the endocrine system, an important role is played by the principle of self-regulation, which is carried out by the type of feedback. There are positive (for example, an increase in blood sugar leads to an increase in insulin secretion) and negative feedback (with an increase in the level of thyroid hormones in the blood, the production of thyroid-stimulating hormone and thyreoliberin decreases, which ensure the release of thyroid hormones). So, the direct effect of blood substrate concentrations on gland cells follows the feedback principle. If the level of a substance controlled by a particular hormone changes in the blood, then “a tear responds with an increase or decrease in the secretion of this hormone. Nervous regulation is carried out due to the direct influence of the sympathetic and parasympathetic nerves on the synthesis and secretion of hormones by the neurohypophysis, the adrenal medulla), and also indirectly, “changing the intensity of the blood supply to the gland. Emotional, mental influences through the structures of the limbic system, through the hypothalamus - can significantly affect the production of hormones. Hormonal regulation It is also carried out according to the feedback principle: if the level of the hormone in the blood rises, then in the bloodstream, the release of those hormones that control the content of this hormone decreases, which leads to a decrease in its concentration in the blood. For example, with an increase in the level of cortisone in the blood, the release of ACTH (a hormone that stimulates the secretion of hydrocortisone) decreases and, as a result, Decrease in its level in the blood. Another example of hormonal regulation can be this: melatonin (a hormone of the pineal gland) modulates the function of the adrenal glands, thyroid gland, gonads, i.e. a certain hormone can affect the content of other hormonal factors in the blood. The hypothalamic-pituitary system as the main mechanism of neurohumoral regulation of hormone secretion. The function of the thyroid, sex glands, adrenal cortex is regulated by the hormones of the anterior pituitary gland - the adenohypophysis. Here are synthesized tropic hormones: adrenocorticotropic (ACTH), thyrotropic (TSH), follicle-stimulating (FS) and luteinizing (LH) (Fig. 5). With some conventionality, somatotropic hormone (growth hormone) also belongs to triple hormones, which exerts its influence on growth not only directly, but also indirectly through hormones - somatomedins, which are formed in the liver. All these tropic hormones are so named due to the fact that they provide the secretion and synthesis of the corresponding hormones of other endocrine glands: ACTH - glucocorticoids and mineralocorticoids: TSH - thyroid hormones; gonadotropic - sex hormones. In addition, intermediates (melanocyte-stimulating hormone, MCG) and prolactin are formed in the adenohypophysis, which have an effect on peripheral organs.

Humoral regulation provides longer adaptive reactions of the human body. The factors of humoral regulation include hormones, electrolytes, mediators, kinins, prostaglandins, various metabolites, etc.

The highest form of humoral regulation is hormonal. The term "hormone" in Greek means "stimulating to action", although not all hormones have a stimulating effect.

Hormones - these are biologically highly active substances that are synthesized and released into the internal environment of the body by the endocrine glands, or endocrine glands, and causing a regulatory effect on the functions of organs and body systems remote from their place of secretion, Endocrine gland - this anatomical formation, devoid of excretory ducts, the only or main function of which is the internal secretion of hormones. The endocrine glands include the pituitary gland, pineal gland, thyroid gland, adrenal glands (medulla and cortex), parathyroid glands (Fig. 2.9). Unlike internal secretion, external secretion is carried out by exocrine glands through the excretory ducts into the external environment. In some organs, both types of secretion are simultaneously present. Organs with a mixed type of secretion include the pancreas and gonads. The same endocrine gland can produce hormones that are not the same in their action. For example, the thyroid gland produces thyroxine and thyrocalcitonin. At the same time, the production of the same hormones can be carried out by different endocrine glands.

The production of biologically active substances is a function not only of the endocrine glands, but also of other traditionally non-endocrine organs: the kidneys, the gastrointestinal tract, and the heart. Not all substances formed

specific cells of these organs, satisfy the classical criteria for the concept of "hormones". Therefore, along with the term "hormone", the concepts of hormone-like and biologically active substances (BAS ), local hormones . For example, some of them are synthesized so close to their target organs that they can reach them by diffusion without entering the bloodstream.

Cells that produce such substances are called paracrine.

The chemical nature of hormones and biologically active substances is different. The duration of its biological action depends on the complexity of the hormone structure, for example, from fractions of a second for mediators and peptides to hours and days for steroid hormones and iodothyronines.

Hormones are characterized by the following main properties:

Rice. 2.9 General topography of the endocrine glands:

1 - pituitary gland; 2 - thyroid gland; 3 - thymus gland; 4 - pancreas; 5 - ovary; 6 - placenta; 7 - testis; 8 - kidney; 9 - adrenal gland; 10 - parathyroid glands; 11 - epiphysis of the brain

1. Strict specificity of physiological action;

2. High biological activity: hormones exert their physiological effects in extremely small doses;

3. Remote nature of action: target cells are usually located far from the site of hormone formation.

Inactivation of hormones occurs mainly in the liver, where they undergo various chemical changes.

Hormones perform the following important functions in the body:

1. Regulation of growth, development and differentiation of tissues and organs, which determines physical, sexual and mental development;

2. Ensuring the adaptation of the body to changing conditions of existence;

3. Ensuring the maintenance of the constancy of the internal environment of the body.

The activity of the endocrine glands is regulated by nervous and humoral factors. The regulatory influence of the central nervous system on the activity of the endocrine glands is carried out through the hypothalamus. The hypothalamus receives signals from the external and internal environment along the afferent pathways of the brain. Neurosecretory cells of the hypothalamus transform afferent nerve stimuli into humoral factors.

In the system of endocrine glands, the pituitary gland occupies a special position. The pituitary gland is referred to as the "central" endocrine gland. This is due to the fact that the pituitary gland, through its special hormones, regulates the activity of other, so-called "peripheral" glands.

The pituitary gland is located at the base of the brain. Structurally, the pituitary gland is a complex organ. It consists of anterior, middle and posterior lobes. The pituitary gland is well supplied with blood.

Somatotropic hormone, or growth hormone (somatotropin), prolactin, thyroid-stimulating hormone (thyrotropin), etc. are formed in the anterior pituitary gland. Somatotropin is involved in the regulation of growth, due to its ability to enhance the formation of protein in the body. The effect of the hormone on bone and cartilage tissue is most pronounced. If the activity of the anterior pituitary gland (hyperfunction) is manifested in childhood, then this leads to an increased growth of the body in length - gigantism. With a decrease in the function of the anterior pituitary gland (hypofunction) in a growing organism, a sharp growth retardation occurs - dwarfism Excess hormone production in an adult does not affect the growth of the body as a whole, since it has already been completed. Prolactin promotes the formation of milk in the alveoli of the mammary gland.

Thyrotropin stimulates thyroid function. Corticotropin is a physiological stimulator of the fascicular and reticular zones of the adrenal cortex, where glucocorticoids are formed.

Corticotropin causes breakdown and inhibits protein synthesis in the body. In this regard, the hormone is an antagonist of somatotropin, which enhances protein synthesis.

In the middle lobe of the pituitary gland, a hormone is formed that affects the pigment metabolism.

The posterior lobe of the pituitary gland is closely related to the nuclei of the hypothalamic region. The cells of these nuclei are able to form substances of a protein nature. The resulting neurosecretion is transported along the axons of the neurons of these nuclei to the posterior lobe of the pituitary gland. In the nerve cells of the nuclei, the hormones oxytocin and vasopressin are formed.

Or vasopressin, performs two functions in the body. The first function is associated with the effect of the hormone on the smooth muscles of arterioles and capillaries, the tone of which it increases, which leads to an increase in blood pressure. The second and main function is associated with, expressed in its ability to enhance the reverse absorption of water from the tubules of the kidneys into the blood.

The pineal body (pineal gland) is an endocrine gland, which is a cone-shaped formation, which is located in the diencephalon. In appearance, iron resembles a spruce cone.

The pineal gland produces primarily serotonin and melatonin, as well as norepinephrine, histamine. Peptide hormones and biogenic amines were found in the epiphysis. The main function of the pineal gland is the regulation of daily biological rhythms, endocrine functions and metabolism, the adaptation of the body to changing light conditions. Excess light inhibits the conversion of serotonin to melatonin and promotes the accumulation of serotonin and its metabolites. In the dark, on the contrary, the synthesis of melatonin is enhanced.

The thyroid gland consists of two lobes located on the neck on both sides of the trachea below the thyroid cartilage. The thyroid gland produces iodine-containing hormones - thyroxine (tetraiodothyronine) and triiodothyronine. There is more thyroxine in the blood than triiodothyronine. However, the activity of the latter is 4-10 times higher than that of thyroxin. The human body has a special hormone thyrocalcitonin, which is involved in the regulation of calcium metabolism. Under the influence of thyrocalcitonin, the level of calcium in the blood decreases. The hormone inhibits the excretion of calcium from the bone tissue and increases its deposition in it.

There is a relationship between the content of iodine in the blood and the hormone-forming activity of the thyroid gland. Small doses of iodine stimulate, and large ones inhibit the processes of hormone formation.

The autonomic nervous system plays an important role in regulating the formation of hormones in the thyroid gland. Excitation of its sympathetic department leads to an increase, and the predominance of parasympathetic tone causes a decrease in the hormone-forming function of this gland. In the neurons of the hypothalamus, substances (neurosecrete) are formed, which, entering the anterior lobe of the pituitary gland, stimulate the synthesis of thyrotropin. With a lack of thyroid hormones in the blood, there is an increased formation of these substances in the hypothalamus, and with an excess content, their synthesis is inhibited, which in turn reduces the production of thyrotropin in the anterior pituitary gland.

The cerebral cortex is also involved in the regulation of thyroid activity.

The secretion of thyroid hormones is regulated by the content of iodine in the blood. With a lack of iodine in the blood, as well as iodine-containing hormones, the production of thyroid hormones increases. With an excess amount of iodine in the blood and thyroid hormones, a negative feedback mechanism works. Excitation of the sympathetic division of the autonomic nervous system stimulates the hormone-forming function of the thyroid gland, excitation of the parasympathetic division inhibits it.

Thyroid function disorders are manifested by its hypofunction and hyperfunction. If the insufficiency of the function develops in childhood, then this leads to growth retardation, violation of body proportions, sexual and mental development. This pathological condition is called cretinism. In adults, hypofunction of the thyroid gland leads to the development of a pathological condition - myxedema. In this disease, inhibition of neuropsychic activity is observed, which manifests itself in lethargy, drowsiness, apathy, decreased intelligence, decreased excitability of the sympathetic division of the autonomic nervous system, sexual dysfunction, inhibition of all types of metabolism and a decrease in basal metabolism. In such patients, body weight is increased due to an increase in the amount of tissue fluid and puffiness of the face is noted. Hence the name of this disease: myxedema - mucous edema.

Hypothyroidism can develop in people living in areas where there is a lack of iodine in water and soil. This is the so-called endemic goiter. The thyroid gland in this disease is enlarged (goiter), however, due to a lack of iodine, little hormones are produced, which leads to corresponding disorders in the body, manifested as hypothyroidism.

With hyperfunction of the thyroid gland, the disease develops thyrotoxicosis (diffuse toxic goiter, Basedow's disease, Graves' disease). The characteristic signs of this disease are an increase in the thyroid gland (goiter), an increase in metabolism, especially the main one, loss of body weight, an increase in appetite, a violation of the body's heat balance, increased excitability and irritability.

The parathyroid glands are a paired organ. A person has two pairs of parathyroid glands located on the back surface or immersed inside the thyroid gland.

The parathyroid glands are well supplied with blood. They have both sympathetic and parasympathetic innervation.

The parathyroid glands produce parathormone (parathyrin). From the parathyroid glands, the hormone enters directly into the blood. Parathyroid hormone regulates calcium metabolism in the body and maintains a constant level in the blood. In case of insufficiency of the parathyroid glands (hypoparathyroidism), there is a significant decrease in the level of calcium in the blood. On the contrary, with increased activity of the parathyroid glands (hyperparathyroidism), an increase in the concentration of calcium in the blood is observed.

The bone tissue of the skeleton is the main depot of calcium in the body. Therefore, there is a definite relationship between the level of calcium in the blood and its content in bone tissue. Parathyroid hormone regulates the processes of calcification and decalcification (deposition and release of calcium salts) in the bones. Influencing the exchange of calcium, the hormone simultaneously affects the exchange of phosphorus in the body.

The activity of these glands is determined by the level of calcium in the blood. There is an inverse relationship between the hormone-forming function of the parathyroid glands and the level of calcium in the blood. If the concentration of calcium in the blood increases, then this leads to a decrease in the functional activity of the parathyroid glands. With a decrease in the level of calcium in the blood, an increase in the hormone-forming function of the parathyroid glands occurs.

The thymus gland (thymus) is a paired lobular organ located in the chest cavity behind the sternum.

The thymus gland consists of two lobes of unequal size, interconnected by a layer of connective tissue. Each lobe of the thymus gland includes small lobules, in which the cortical and medulla layers are distinguished. The cortical substance is represented by the parenchyma, in which there are a large number of lymphocytes. The thymus gland is well supplied with blood. It forms several hormones: thymosin, thymopoietin, thymic humoral factor. All of them are proteins (polypeptides). The thymus gland plays an important role in the regulation of the body's immune processes, stimulating the formation of antibodies, controls the development and distribution of lymphocytes involved in immune reactions.

The thymus reaches its maximum development in childhood. After the onset of puberty, it stops in development and begins to atrophy. The physiological significance of the thymus also lies in the fact that it contains a large amount of vitamin C, yielding in this respect only to the adrenal glands.

The pancreas is a mixed function gland. As an external secretion gland, it produces pancreatic juice, which is secreted through the excretory duct into the duodenal cavity. The intrasecretory activity of the pancreas is manifested in its ability to produce hormones that come from the gland directly into the blood.

The pancreas is innervated by sympathetic nerves coming from the celiac (solar) plexus and branches of the vagus nerve. The islet tissue of the gland contains a large amount of zinc. Zinc is also a constituent of insulin. The gland has an abundant blood supply.

The pancreas secretes two hormones, insulin and glucagon, into the blood. Insulin is involved in the regulation of carbohydrate metabolism. Under the action of the hormone, a decrease in the concentration of sugar in the blood occurs - hypoglycemia occurs. If the blood sugar level is normally 4.45-6.65 mmol / l (80-120 mg%), then under the influence of insulin, depending on the dose administered, it becomes below 4.45 mmol / l. The decrease in blood glucose levels under the influence of insulin is due to the fact that the hormone promotes the conversion of glucose into glycogen in the liver and muscles. In addition, insulin increases the permeability of cell membranes to glucose. In this regard, there is an increased penetration of glucose into the cell, where it is utilized. The importance of insulin in the regulation of carbohydrate metabolism also lies in the fact that it prevents the breakdown of proteins and their conversion into glucose. Insulin stimulates protein synthesis from amino acids and their active transport into cells. It regulates fat metabolism, promoting the formation of fatty acids from carbohydrate metabolism products. Insulin inhibits the mobilization of fat from adipose tissue.

The production of insulin is regulated by the level of glucose in the blood. Hyperglycemia leads to an increase in the flow of insulin into the blood. Hypoglycemia reduces the formation and entry of the hormone into the vascular bed. Insulin converts glucose into glycogen and blood sugar returns to normal levels.

If the amount of glucose becomes below the norm and hypoglycemia occurs, then there is a reflex decrease in the formation of insulin.

Insulin secretion is regulated by the autonomic nervous system: excitation of the vagus nerves stimulates the formation and release of the hormone, and sympathetic nerves inhibit these processes.

The amount of insulin in the blood depends on the activity of the enzyme insulinase, which destroys the hormone. The largest amount of the enzyme is found in the liver and skeletal muscles. With a single flow of blood through the liver, insulinase destroys up to 50% of insulin.

Insufficiency of the intrasecretory function of the pancreas, accompanied by a decrease in insulin secretion, leads to a disease called diabetes mellitus. The main manifestations of this disease are: hyperglycemia, glucosuria (sugar in the urine), polyuria (urine excretion increased to 10 liters per day), polyphagia (increased appetite), polydipsia (increased thirst), resulting from loss of water and salts. In patients, not only carbohydrate metabolism is disturbed, but also the metabolism of proteins and fats.

Glucagon is involved in the regulation of carbohydrate metabolism. By the nature of its action on carbohydrate metabolism, it is an insulin antagonist. Under the influence of glucagon, glycogen is broken down in the liver to glucose. As a result, the concentration of glucose in the blood rises. In addition, glucagon stimulates the breakdown of fat in adipose tissue.

The amount of glucose in the blood affects the formation of glucagon. With an increased content of glucose in the blood, inhibition of glucagon secretion occurs, with a decrease - an increase. The formation of glucagon is also influenced by the hormone of the anterior pituitary gland - somatotropin, it increases the activity of cells, stimulating the formation of glucagon.

The adrenal glands are paired glands. They are located directly above the upper poles of the kidneys, surrounded by a dense connective tissue capsule and immersed in adipose tissue. The bundles of the connective capsule penetrate the gland, passing into the septa, which divide the adrenal glands into two layers - cortical and cerebral. The cortical layer of the adrenal glands consists of three zones: glomerular, fascicular and reticular.

The cells of the glomerular zone lie directly under the capsule, collected in glomeruli. In the fascicular zone, the cells are arranged in the form of longitudinal columns or bundles. All three zones of the adrenal cortex are not only morphologically separate structural formations, but also perform different physiological functions.

The adrenal medulla is composed of tissue containing two types of cells that produce adrenaline and norepinephrine.

The adrenal glands are richly supplied with blood and are innervated by sympathetic and parasympathetic nerves.

They are an endocrine organ that is of vital importance. Removal of both adrenal glands results in death. It is shown that the cortical layer of the adrenal glands is vital.

The hormones of the adrenal cortex are divided into three groups:

1) glucocorticoids - hydrocortisone, cortisone and corticosterone;

2) mineralocorticoids - aldosterone, deoxycorticosterone;

3) sex hormones - androgens, estrogens, progesterone.

The formation of hormones occurs mainly in one zone of the adrenal cortex. So, mineralocorticoids are produced in the cells of the glomerular zone, glucocorticoids - in the bundle zone, sex hormones - in the reticular zone.

According to the chemical structure, the hormones of the adrenal cortex are steroids. They are formed from cholesterol. For the synthesis of hormones of the adrenal cortex, ascorbic acid is also necessary.

Glucocorticoids affect the metabolism of carbohydrates, proteins and fats. They stimulate the formation of glucose from proteins, the deposition of glycogen in the liver. Glucocorticoids are insulin antagonists in the regulation of carbohydrate metabolism: they delay the utilization of glucose in tissues, and in case of an overdose of them, an increase in the concentration of sugar in the blood and its appearance in the urine can occur.

Glucorticoids cause the breakdown of tissue protein and prevent the incorporation of amino acids into proteins and thereby delay the formation of granulations and subsequent scar formation, which adversely affects wound healing.

Glucocorticoids are anti-inflammatory hormones, as they have the ability to inhibit the development of inflammatory processes, in particular, by reducing the permeability of vascular membranes.

Mineralocorticoids are involved in the regulation of mineral metabolism. In particular, aldosterone enhances the reabsorption of sodium ions in the renal tubules and reduces the reabsorption of potassium ions. As a result, sodium excretion in the urine decreases and potassium excretion increases, which leads to an increase in the concentration of sodium ions in the blood and tissue fluid and an increase in osmotic pressure.

The sex hormones of the adrenal cortex stimulate the development of the genital organs in childhood, that is, when the intrasecretory function of the sex glands is still poorly developed. The sex hormones of the adrenal cortex determine the development of secondary sexual characteristics and the functioning of the genital organs. They also have an anabolic effect on protein metabolism, stimulating protein synthesis in the body.

An important role in the regulation of the formation of glucocorticoids in the adrenal cortex is performed by adrenocorticotropic hormone of the anterior pituitary gland. The influence of corticotropin on the formation of glucocorticoids in the adrenal cortex is carried out according to the principle of direct and feedback: corticotropin stimulates the production of glucocorticoids, and an excess of these hormones in the blood leads to inhibition of the synthesis of corticotropin in the anterior pituitary gland.

In addition to the pituitary gland, the hypothalamus is involved in the regulation of the formation of glucocorticoids. In the nuclei of the anterior hypothalamus, a neurosecrete is produced, which contains a protein factor that stimulates the formation and release of corticotropin. This factor through the common circulatory system of the hypothalamus and pituitary gland enters its anterior lobe and promotes the formation of corticotropin. Functionally, the hypothalamus, the anterior pituitary gland, and the adrenal cortex are closely related.

The formation of mineralocorticoids is influenced by the concentration of sodium and potassium ions in the body. An increased amount of sodium ions in the blood and tissue fluid or an insufficient content of potassium ions in the blood leads to inhibition of the secretion of aldosterone in the adrenal cortex, which leads to an increased excretion of sodium in the urine. With a lack of sodium ions in the internal environment of the body, aldosterone production increases, and as a result, the reabsorption of these ions in the renal tubules increases. An excess concentration of potassium ions in the blood stimulates the formation of aldosterone in the adrenal cortex. The formation of mineralocorticoids is influenced by the amount of tissue fluid and blood plasma. An increase in their volume leads to inhibition of aldosterone secretion, which is accompanied by an increased release of sodium ions and water associated with it.

The adrenal medulla produces catecholamines: adrenaline and norepinephrine (a precursor of adrenaline in the process of its biosynthesis). Adrenaline performs the functions of a hormone, it comes from the adrenal glands into the blood constantly. In some emergency conditions of the body (acute lowering of blood pressure, blood loss, cooling of the body, hypoglycemia, increased muscle activity: emotions - pain, fear, rage), the formation and release of the hormone into the vascular bed increases.

Excitation of the sympathetic nervous system is accompanied by an increase in the flow of adrenaline and noradrenaline into the blood. These catecholamines enhance and prolong the effects of the influence of the sympathetic nervous system. On the functions of organs and the activity of physiological systems, adrenaline has the same effect as the sympathetic nervous system. Adrenaline has a pronounced effect on carbohydrate metabolism, increasing the breakdown of glycogen in the liver and muscles, resulting in an increase in blood glucose. It increases the excitability and contractility of the heart muscle, and also increases the heart rate. The hormone increases vascular tone, and therefore increases blood pressure. However, adrenaline has a vasodilating effect on the coronary vessels of the heart, vessels of the lungs, brain and working muscles.

Adrenaline enhances the contractile effect of skeletal muscles, inhibits the motor function of the gastrointestinal tract and increases the tone of its sphincters.

Adrenaline is one of the so-called short-acting hormones. This is due to the fact that the hormone is rapidly destroyed in the blood and tissues.

Norepinephrine, unlike adrenaline, performs the function of a mediator - a transmitter of excitation from nerve endings to an effector. Norepinephrine is also involved in the transmission of excitation in the neurons of the central nervous system.

The secretory function of the adrenal medulla is controlled by the hypothalamic region of the brain, since the higher autonomic centers of the sympathetic nervous system are located in the posterior group of its nuclei. When the neurons of the hypothalamus are stimulated, adrenaline is released from the adrenal glands and its content in the blood increases.

The cerebral cortex affects the flow of adrenaline into the vascular bed.

The release of adrenaline from the adrenal medulla can occur reflexively, for example, during muscular work, emotional arousal, body cooling, and other effects on the body. The release of adrenaline from the adrenal glands is regulated by the level of sugar in the blood.

Hormones of the adrenal cortex are involved in the development of adaptive reactions of the body that occur when exposed to various factors (cooling, starvation, trauma, hypoxia, chemical or bacterial intoxication, etc.). In this case, the same type of nonspecific changes occur in the body, manifested primarily by the rapid release of corticosteroids, especially glucocorticoids under the influence of corticotropin.

Gonads (sex glands) ) - testicles (testicles) in men and ovaries in women - are glands with a mixed function. Due to the exocrine function of these glands, male and female sex cells are formed - spermatozoa and eggs. Intrasecretory function is manifested in the secretion of male and female sex hormones that enter the bloodstream.

The development of the gonads and the entry of sex hormones into the blood determines sexual development and maturation. Puberty in humans occurs at the age of 12-16 years. It is characterized by the full development of primary and the appearance of secondary sexual characteristics.

Primary sexual characteristics - signs related to the structure of the gonads and genital organs.

Secondary sexual characteristics - signs related to the structure and function of various organs, except for the genitals. In men, secondary sexual characteristics are facial hair, features of the distribution of hair on the body, a deep voice, a characteristic body structure, mentality and behavior. In women, secondary sexual characteristics include features of the location of hair on the body, body structure, development of the mammary glands.

In special cells of the testicles, male sex hormones are formed: testosterone and androsterone. These hormones stimulate the growth and development of the reproductive apparatus, male secondary sexual characteristics and the appearance of sexual reflexes. Androgens (male sex hormones) are necessary for the normal maturation of male germ cells - spermatozoa. In the absence of hormones, motile mature spermatozoa are not formed. In addition, androgens contribute to a longer preservation of the motor activity of male germ cells. Androgens are also necessary for the manifestation of the sexual instinct and the implementation of related behavioral reactions.

Androgens have a great influence on the metabolism in the body. They increase the formation of protein in various tissues, especially in muscles, reduce body fat, increase basal metabolism.

In the female genital glands - the ovaries - the synthesis of estrogen is carried out.

Estrogens contribute to the development of secondary sexual characteristics and the manifestation of sexual reflexes, and also stimulate the development and growth of the mammary glands.

Progesterone ensures the normal course of pregnancy.

The formation of sex hormones in the sex glands is under the control of gonadotropic hormones of the anterior pituitary gland.

The nervous regulation of the functions of the gonads is carried out in a reflex way due to a change in the process of formation of gonadotropic hormones in the pituitary gland.

7. The expression "sexually horny type" is widespread. What needs and motivations are constantly present in such a person?

8. What is the difference between first love and love at first sight? Needs? Hormones? structure of behavior?

9. Diogenes, a prominent representative of the Cynic philosophical school, lived in a barrel; condemned those who care about the beauty of clothing; masturbated in public; condemned those who use dishes when eating, denied patriotism. What can be said about the teachings of the Cynics, using the concept of "need"?

10. Why did Natasha Rostova, the bride of Prince Andrei, try to run away with another? What are the motives of her behavior, if we consider them from the point of view of biology?

11. What is the role of hormones in the organization of needs; motivation; movement?

12. What is a "mental state"?

Dewsbury D. Animal behavior. Comparative aspects. M., 1981.

Zorina Z. A., Poletaeva I. I., Reznikova Zh. I. Fundamentals of ethology and genetics of behavior. M., 1999.

McFarland D. Animal behavior. Psychobiology, ethology and evolution. M., 1988.

Simonov P.V. Motivated brain. M., 1987.

Simonov P.V. Emotional brain. M., 1981.

Tinbergen N. Animal behavior. M., 1978.

Chapter 3
humoral system

A common part.Differences between nervous and humoral regulation. Functional division of humoral agents: hormones, pheromones, mediators and modulators.

Major hormones and glands.The hypothalamic-pituitary system. Hypothalamic and pituitary hormones. Vasopressin and oxytocin. peripheral hormones. Steroid hormones. Melatonin.

Principles of hormonal regulation.Transmission of a hormonal signal: synthesis, secretion, transport of hormones, their action on target cells and inactivation. Polyvalence of hormones. Regulation by the mechanism of negative feedback and its important consequence. Interaction of endocrine systems: feed-forward, feedback, synergism, permissive action, antagonism. Mechanisms of hormonal influences on behavior.

The exchange of carbohydrates.The value of carbohydrates. Psychotropic effect of carbohydrates. The content of glucose in the blood is the most important constant. Humoral influences on various stages of carbohydrate metabolism. Metabolic and hedonic function of carbohydrates.

A complex example of the psychotropic effect of hormones: premenstrual syndrome.Influence of contraceptives. The effect of excess salt in the diet. Influence of dietary carbohydrates. The influence of alcohol.

Humoral (“humor” - liquid) control of body functions is carried out by substances carried throughout the body with fluids, primarily with blood. Blood and other fluids carry substances that enter the body from the external environment, in particular, with a diet, 37
A diet is not a restriction of nutrition, but everything that enters the body with food.

As well as substances produced inside the body - hormones.

Nervous control is carried out with the help of impulses distributed along the processes of nerve cells. The convention of division into nervous and humoral mechanisms of regulation of functions is already manifested in the fact that the nerve impulse is transmitted from cell to cell with the help of a humoral signal - neurotransmitter molecules are released in the nerve ending, which is a humoral factor.

Humoral and nervous systems of regulation are two aspects of a single system of neurohumoral regulation of integral body functions.

All body functions are under double control: nervous and humoral. Absolutely all organs and tissues of the human body are under humoral influence, while nervous control is absent in two organs: the adrenal cortex and the placenta. This means that these two organs do not have nerve endings. However, this does not mean that the functions of the adrenal cortex and the placenta are outside the sphere of nervous influences. As a result of the activity of the nervous system, the release of hormones that regulate the functions of the adrenal cortex and the placenta changes.

Nervous and humoral regulation are equally important for the preservation of the organism as a whole, including the organization of behavior. It should be emphasized once again that humoral and nervous regulation are not, strictly speaking, different systems of regulation. They represent two sides of a single neurohumoral system. The role and share of participation of each of the two systems is different for different functions and conditions of the body. But in the regulation of an integral function, both humoral and purely nervous influences are always present. The division into nervous and humoral mechanisms is due to the fact that either physical or chemical methods are used to study them. To study nervous mechanisms, only methods of recording electric fields are more often used. The study of humoral mechanisms is impossible without the use of biochemical methods.

3.1.1. Differences between nervous and humoral regulation

Two systems - nervous and humoral - differ in the following properties. First, neural regulation is purposeful. The signal along the nerve fiber comes to a strictly defined place: to a certain muscle, or to another nerve center, or to a gland. The humoral signal, i.e., hormone molecules, spreads with the blood stream throughout the body. Whether or not tissues and organs will respond to this signal depends on the presence in the cells of these tissues of the perceiving apparatus - molecular receptors (see Section 3.3.1).

Secondly, the nerve signal is fast, it moves to another organ - another nerve cell, muscle cell, gland cell - at a speed of 7 to 140 m / s, delaying only 1 millisecond when switching in synapses. Thanks to neural regulation, we can do something "in the blink of an eye." The blood content of most hormones in the blood increases only a few minutes after stimulation, and reaches a maximum only not earlier than 30 minutes, or even one hour. Therefore, the maximum effect of the hormone can be observed several hours after a single exposure to the body. Thus, the humoral signal is slow.

Thirdly, the nerve signal is short. As a rule, a burst of impulses caused by a stimulus lasts no more than a fraction of a second. This is the so-called inclusion reaction. A similar flash of electrical activity in the nerve nodes is noted when the stimulus is terminated - the off response. The humoral system, on the other hand, carries out slow tonic regulation, that is, it has a constant effect on the organs, maintaining their function in a certain state. This manifests the providing function of humoral factors (see section 1.2.2). The hormone level can remain elevated throughout the duration of the stimulus, and, in some conditions, up to several months. Such a persistent change in the level of activity of the nervous system is typical, as a rule, for an organism with impaired functions.

The main differences between nervous regulation and humoral regulation are as follows: the nerve signal is purposeful; nerve signal is fast; nerve signal is short.

Another difference, or rather a group of differences, between the two systems of regulation of functions is due to the fact that the study of the nervous regulation of behavior is more attractive when conducting studies on humans. The most popular method of recording electric fields in humans is the recording of an electroencephalogram (EEG), i.e., the electric fields of the brain. Its use does not cause pain, while taking a blood test to study humoral factors is associated with pain. The fear that many people feel when waiting for an injection can affect - and indeed does - affect some of the results of the analysis. When a needle is inserted into the body, there is a risk of infection. Such a danger is negligible when registering an EEG. Finally, EEG registration is more cost-effective. If the determination of biochemical parameters requires constant financial outlays for the purchase of chemical reagents, then for long-term and large-scale EEG studies, a one-time financial investment, albeit a large one, is sufficient for the purchase of an electroencephalograph.

As a result of all these circumstances, the study of the humoral regulation of human behavior is carried out mainly in clinics, that is, it is a side result of therapeutic measures. Therefore, experimental data on the participation of humoral factors in the organization of the integral behavior of a healthy person are incomparably less than experimental data on nervous mechanisms. When studying psychophysiological data, this should be borne in mind - the physiological mechanisms underlying psychological reactions are not limited to EEG changes. In a number of cases, EEG changes only reflect the mechanisms that are based on diverse, including humoral, processes. For example, interhemispheric asymmetry - differences in EEG recording on the left and right sides of the head - is based mainly on the action of sex hormones.

3.1.2. Functional division of humoral agents: hormones, pheromones, mediators and neuromodulators

The endocrine system is made up of endocrine glands - glands that synthesize biologically active substances and secrete (release) them into the internal environment (usually into the circulatory system), which carries them throughout the body. The secret of the endocrine glands is called hormones. Hormones are one of the groups of biologically active substances secreted in the body of humans and animals. These groups differ in the nature of secretion.

"Internal secretion" means that substances are secreted into the blood or other internal fluid; "external secretion" means that substances are secreted into the digestive tract or onto the surface of the skin.

In addition to internal secretion, there is also external. It includes the release of digestive enzymes into the gastrointestinal tract and various substances through sweat, urine and feces. Together with metabolic products, biologically active substances specially synthesized in various tissues, called pheromones, are released into the environment. They perform a signaling function in communication between members of the community. Pheromones, which are perceived by animals with the help of smell and taste, carry information about the sex, age, condition (fatigue, fear, illness) of the animal. Moreover, with the help of pheromones, an individual recognition of one animal by another and even the degree of relationship of two individuals occurs. Pheromones play a special role in the early stages of maturation of the body, in infancy. At the same time, pheromones of both mother and father are important. In their absence, the development of the newborn slows down and may be disturbed.

Pheromones cause certain reactions in other individuals of the same species, and chemicals secreted by animals of one species, but perceived by animals of another species, are called kairomones. Thus, in the animal community, pheromones perform the same function as hormones inside the body. Since humans have a much weaker sense of smell than animals, pheromones play a smaller role in the human community than in the animal community. However, they affect human behavior, in particular interpersonal relationships (see section 7.4).

Substances that are not classified as hormones, i.e., endocrine agents, are also involved in the humoral regulation of functions, since they are not secreted into the circulatory or lymphatic systems - these are mediators (neurotransmitters). They are released by the nerve ending into the synaptic cleft, transmitting signals from one neuron to another. Inside the synapse, they break up without entering the bloodstream. Among substances secreted by tissues that are not classified as hormones, a group of neuromodulators, or local hormones, is distinguished. These substances do not spread with the blood flow throughout the body, like true hormones, but act on a group of nearby cells, being released into the intercellular space.

The difference between types of humoral agents is a functional difference. The same chemical substance can act as a hormone, as a pheromone, as a neurotransmitter and as a neuromodulator.

It should be emphasized that the above division of secretion products into groups is called functional, since it is made according to the physiological principle. The same chemical substance can perform different functions, being released in different tissues. For example, vasopressin, secreted in the posterior pituitary gland, is a hormone. He, standing out in synapses in various structures of the brain, is in these cases a mediator. Dopamine, being a hypothalamic hormone, is released into the circulatory system that connects the hypothalamus with the pituitary gland, and at the same time, dopamine is a mediator in many brain structures. Norepinephrine, secreted by the medulla of the adrenal glands into the systemic circulation, performs the functions of a hormone, being secreted in the synapses - a mediator. Finally, getting (in a not entirely clear way) into the intercellular space in some structures of the brain, it is a neuromodulator.

Many biologically active substances, although they are distributed with the bloodstream throughout the body, do not belong to hormones, since they are not synthesized by specialized cells, but are metabolic products, i.e. they enter the circulatory system as a result of the breakdown of nutrients in the gastrointestinal tract. These are, first of all, numerous amino acids (glycine, GABA, tyrosine, tryptophan, etc.) and glucose. These simple chemical compounds influence various forms of human and animal behavior.

Thus, the basis of the system of humoral regulation of the functions of the human and animal body is hormones, i.e. biologically active substances that are synthesized by specialized cells, secreted into the internal environment, transported throughout the body with the bloodstream and change the functions of target tissues.

Hormones are biologically active substances synthesized by specialized cells, secreted into the internal environment, transported with the bloodstream throughout the body and changing the functions of target tissues.

The role of neurotransmitters and neuromodulators is not considered and hardly mentioned in this book, since they are not systemic factors that organize behavior - they act at the point of contact of nerve cells, or in an area limited by several nerve cells. In addition, consideration of the role of mediators and neuromodulators would require a preliminary presentation of a number of biological disciplines.

3.2. Major hormones and glands

Data from studies of the endocrine system, that is, the system of the endocrine glands, obtained in recent years, allow us to say that the endocrine system "penetrates" almost the entire body. Hormone-secreting cells are found in virtually every organ whose primary function has long been known to be unrelated to the endocrine gland system. So, hormones of the heart, kidneys, lungs and numerous hormones of the gastrointestinal tract were found. The number of hormones found in the brain is so great that the volume of studies of the secretory function of the brain is now comparable to the volume of electrophysiological studies of the CNS. This led to the joke “The brain is not only an endocrine organ,” reminding researchers that the main function of the brain is, after all, the integration of many bodily functions into a coherent system. Therefore, only the main endocrine glands and the central endocrine link of the brain will be described here.

3.2.1. Hypothalamic-pituitary system

The hypothalamus is the highest division of the endocrine system. This structure of the brain receives and processes information about changes in motivational systems, changes in the external environment and in the state of internal organs, changes in the humoral constants of the body.

In accordance with the needs of the body, the hypothalamus modulates the activity of the endocrine system, controlling the functions of the pituitary gland (Fig. 3-1).

Modulation (i.e. activation or inhibition) is carried out through the synthesis and secretion of special hormones - releasing ( release- allocate), which, entering the special (portal) circulatory system, are transported to the anterior lobe of the pituitary gland. In the anterior pituitary, hypothalamic hormones stimulate (or inhibit) the synthesis and secretion of pituitary hormones that enter the general circulation. Part of the pituitary hormones are tropic ( tropos- direction) by hormones, i.e. they stimulate the secretion of hormones from peripheral glands: the adrenal cortex, gonads (sex glands) and the thyroid gland. There are no pituitary hormones that inhibit the function of peripheral glands. Another part of the pituitary hormones does not act on the peripheral glands, but directly on the organs and tissues. For example, prolactin stimulates the mammary gland. Peripheral hormones, interacting with the pituitary and hypothalamus, inhibit the feedback mechanism of the secretion of the corresponding hypothalamic and pituitary hormones. Such, in the most general terms, is the organization of the central department of the endocrine system.

Rice. 3–1. A is a drawing by Leonardo da Vinci. The hypothalamus is located approximately at the point of intersection of the planes.

B – Scheme of the structure of the hypothalamic-pituitary region: 1 – hypothalamus, 2 – anterior pituitary gland, 3 – posterior pituitary gland: (a) neurons synthesizing vasopressin and oxytocin; (b) neurons secreting releasing hormones; (c) anterior pituitary cell secreting tropic hormones; (d) portal circulatory system, through which releasing hormones are transferred from the hypothalamus to the pituitary gland; (e) – systemic circulation, into which pituitary hormones enter.

Oxytocin and vasopressin, synthesized in the hypothalamic neurons, enter the synapses through the processes of nerve cells, which border directly on the blood vessels. Thus, these two hormones, synthesized in the hypothalamus, are released into the bloodstream in the pituitary gland. Other hormones, synthesized in the hypothalamus, enter the vessels of the portal circulatory system, which connects the hypothalamus and pituitary gland. In the pituitary gland, they are released and act on the cells of the pituitary gland, regulating the synthesis and secretion of pituitary hormones that enter the general circulation.

In the hypothalamus, the processes of processing information entering the central nervous system are integrated. The hypothalamus also produces releasing hormones that control the pituitary gland. In the pituitary gland, under the influence of hypothalamic hormones, the synthesis of pituitary hormones increases or decreases. Pituitary hormones are distributed with the general circulation. Some of them affect the tissues of the body, and some stimulate the synthesis of hormones in the peripheral endocrine glands (called tropic hormones).

Part of the hypothalamic neurons, in which releasing hormones are synthesized, gives rise to processes in many parts of the brain. In these neurons, releasing hormone molecules, being released in synapses, act as mediators.

By chemical nature, all hypothalamic and pituitary hormones are peptides, that is, they consist of amino acids. Peptides are called proteins, the molecules of which consist of a small number of amino acids - no more than a hundred. For example, the thyreoliberin molecule consists of three amino acids, the corticoliberin molecule consists of 41, and the molecule of a hormone such as prolactin inhibitory factor (which will not be discussed in this course) consists of only one amino acid. Due to their peptide nature, all hypothalamic and pituitary hormones, entering the bloodstream, are very quickly decomposed by enzymes. The time for which the content of the introduced peptide is halved (half-life) is usually a few minutes. This makes it difficult to identify them and determines some features of their action. Additional difficulties in determining the concentration of hypothalamic hormones are created by the fact that in the absence of external stimuli, their secretion occurs in separate peaks. Therefore, for most hypothalamic hormones, their concentration in the blood in a state of physiological norm is determined only by indirect methods.

All hypothalamic hormones, in addition to endocrine functions, have a pronounced psychotropic effect. Unlike hypothalamic, not all pituitary hormones have a psychotropic effect. For example, the influence of follicle-stimulating and luteotropic hormones on behavior is due only to their influence on other endocrine glands.

All hypothalamic hormones affect mental functions, that is, they are psychotropic agents.

3.2.2. Hypothalamic and pituitary hormones

In detail, we will consider only some of the hypothalamic hormones and the corresponding endocrine systems. Corticoliberin (CRH), synthesized in the hypothalamus, stimulates the secretion of adrenocorticotropic hormone (ACTH) in the anterior pituitary gland. ACTH stimulates the function of the adrenal cortex. Gonadoliberin (GnRH or LH-RH), synthesized in the hypothalamus, stimulates the secretion of follicle-stimulating (FSH) and luteotropic (LH) hormones in the anterior pituitary gland. FSH and LH stimulate the function of the gonads (sex glands). LH stimulates the production of sex hormones, and FSH stimulates the production of germ cells in the gonads. Thyreoliberin (TRH), synthesized in the hypothalamus, stimulates the secretion of thyroid-stimulating hormone (TSH) in the anterior pituitary gland. TSH stimulates the secretory activity of the thyroid gland.

In the hypothalamus (as well as in other structures of the central nervous system) and in the pituitary gland, endorphins and enkephalins are secreted. These are groups of peptide hormones (in the pituitary gland) and neuromodulators and mediators (in the hypothalamus), which have two main functions: they reduce pain and improve mood - they cause euphoria. Due to the euphoric effect of these hormones, i.e., the ability to cheer up, they are involved in the development of new forms of behavior, being part of the reward system in the central nervous system. The secretion of endorphins increases with stress.

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Perm State

Technical University

Department of Physical Culture.

Regulation of nervous activity: humoral and nervous.
Features of the functioning of the central nervous system.

Completed by: student of ASU-01-1 group
Kiselev Dmitry

Checked: _______________________

_______________________

Perm 2003

The human body as a single self-developing and self-regulating system.

All living things are characterized by four features: growth, metabolism, irritability and the ability to reproduce themselves. The combination of these features is characteristic only of living organisms. Man, like all other living beings, also has these abilities.

A normal healthy person does not notice the internal processes occurring in his body, for example, how his body processes food. This is because in the body all systems (nervous, cardiovascular, respiratory, digestive, urinary, endocrine, sexual, skeletal, muscular) harmoniously interact with each other without interference in this process directly by the person himself. We often do not even realize how this happens, and how all the most complex processes in our body are controlled, how one vital body function is combined, interacts with another. How nature or God took care of us, what tools they provided our body with. Consider the mechanism of control and regulation in our body.

In a living organism, cells, tissues, organs and organ systems work as a whole. Their coordinated work is regulated by two fundamentally different, but aimed at the same way: humorally (from lat. "humor"- fluid: through the blood, lymph, intercellular fluid) and nervously. Humoral regulation is carried out with the help of biologically active substances - hormones. Hormones are secreted by endocrine glands. The advantage of humoral regulation is that hormones are delivered through the blood to all organs. Nervous regulation is carried out by the organs of the nervous system and acts only on the "target organ". Nervous and humoral regulation carries out the interconnected and coordinated work of all organ systems, so the body functions as a whole.

humoral system

The humoral system for regulating metabolism in the body is a combination of endocrine and mixed secretion glands, as well as ducts that allow biologically active substances (hormones) to reach the blood vessels or directly the organs that are affected.

Below is a table that shows the main glands of internal and mixed secretion and the hormones they secrete.

As can be seen from the table above, the endocrine glands affect both ordinary organs and other endocrine glands (this ensures self-regulation of the activity of the endocrine glands). The slightest disturbances in the activity of this system lead to developmental disorders of the entire organ system (for example, hypofunction of the pancreas develops diabetes mellitus, and hyperfunction of the anterior pituitary gland may develop gigantism).

The lack of certain substances in the body can lead to the inability to produce certain hormones in the body and, as a result, to impaired development. For example, insufficient intake of iodine (J) in the diet can lead to the inability to produce thyroxine (hypothyroidism), which can lead to the development of diseases such as myxedema (skin dries out, hair falls out, metabolism decreases) and even cretinism (growth retardation, mental development).

Nervous system

The nervous system is the unifying and coordinating system of the body. It includes the brain, spinal cord, nerves, and related structures such as the meninges (layers of connective tissue around the brain and spinal cord).

Despite a well-defined functional separation, the two systems are largely related.

With the help of the cerebrospinal system (see below), we feel pain, temperature changes (heat and cold), touch, perceive the weight and size of objects, touch the structure and shape, the position of body parts in space, feel vibration, taste, smell, light and sound. In each case, stimulation of the sensory endings of the corresponding nerves causes a stream of impulses that are transmitted by individual nerve fibers from the site of the stimulus to the corresponding part of the brain, where they are interpreted. In the formation of any of the sensations, the impulses propagate through several neurons separated by synapses until they reach the awareness centers in the cerebral cortex.

In the central nervous system, the received information is transmitted by neurons; the pathways they form are called tracts. All sensations, except visual and auditory, are interpreted in the opposite half of the brain. For example, the touch of the right hand is projected to the left hemisphere of the brain. Sound sensations coming from each side go to both hemispheres. Visually perceived objects are also projected to both halves of the brain.

The figures on the left show the anatomical arrangement of the organs of the nervous system. The figure shows that the central part of the nervous system (the brain and spinal cord) are concentrated in the head and in the spinal canal, while the organs of the peripheral part of the nervous system (nerves and ganglia) are dispersed throughout the body. Such a device of the nervous system is the most optimal and developed evolutionarily.

Conclusion

Nervous and humoral systems have the same goal - to help the body develop, survive in changing environmental conditions, so it makes no sense to talk separately about nervous or humoral regulation. There is a unified neurohumoral regulation that uses "humoral" and "nervous mechanisms" for regulation. "Humoral mechanisms" set the general direction in the development of the organs of the body, and "nerve mechanisms" allow you to correct the development of a particular organ. It is a mistake to assume that the nervous system is given to us only to think, it is a powerful tool that also unconsciously regulates such vital biological processes as food processing, biological rhythms and much more. Amazingly, even the smartest and most active person uses only 4% of their brain capacity. The human brain is a unique mystery that has been fought over from ancient times to the present day and, perhaps, will be fought for more than one thousand years.

Bibliography:

1. "General biology" under the editorship; ed. "Enlightenment" 1975

3. Encyclopedia "Round the World"

4. Personal notes in biology grades 9-11

A variety of life-support processes are constantly taking place in the human body. So, during the period of wakefulness, all organ systems function simultaneously: a person moves, breathes, blood flows through his vessels, digestion processes take place in the stomach and intestines, thermoregulation is carried out, etc. A person perceives all changes occurring in the environment, reacts to them. All these processes are regulated and controlled by the nervous system and glands of the endocrine apparatus.

Humoral regulation (from Latin "humor" - liquid) - a form of regulation of the body's activity, inherent in all living things, is carried out with the help of biologically active substances - hormones (from the Greek "gormao" - excite), which are produced by special glands. They are called endocrine glands or endocrine glands (from the Greek "endon" - inside, "krineo" - to secrete). The hormones they secrete enter directly into the tissue fluid and into the blood. The blood carries these substances throughout the body. Once in organs and tissues, hormones have a certain effect on them, for example, they affect tissue growth, the rhythm of contraction of the heart muscle, cause narrowing of the lumen of blood vessels, etc.

Hormones affect strictly defined cells, tissues or organs. They are very active, acting even in negligible amounts. However, hormones are rapidly destroyed, so they must enter the blood or tissue fluid as needed as needed.

Usually, the endocrine glands are small: from fractions of a gram to several grams.

The most important endocrine gland is the pituitary gland, located under the base of the brain in a special recess of the skull - the Turkish saddle and connected to the brain by a thin leg. The pituitary gland is divided into three lobes: anterior, middle and posterior. Hormones are produced in the anterior and middle lobes, which, entering the bloodstream, reach other endocrine glands and control their work. Two hormones produced in the neurons of the diencephalon enter the posterior lobe of the pituitary gland along the stalk. One of these hormones regulates the volume of urine produced, and the second enhances the contraction of smooth muscles and plays a very important role in the process of childbirth.

The thyroid gland is located on the neck in front of the larynx. It produces a number of hormones that are involved in the regulation of growth processes, tissue development. They increase the intensity of metabolism, the level of oxygen consumption by organs and tissues.

The parathyroid glands are located on the posterior surface of the thyroid gland. There are four of these glands, they are very small, their total mass is only 0.1-0.13 g. The hormone of these glands regulates the content of calcium and phosphorus salts in the blood, with a lack of this hormone, the growth of bones and teeth is disturbed, and the excitability of the nervous system increases.

Paired adrenal glands are located, as their name implies, above the kidneys. They secrete several hormones that regulate the metabolism of carbohydrates, fats, affect the content of sodium and potassium in the body, and regulate the activity of the cardiovascular system.

The release of adrenal hormones is especially important in cases where the body is forced to work under conditions of mental and physical stress, i.e. under stress: these hormones enhance muscle work, increase blood glucose (to ensure increased energy costs of the brain), increase blood flow in the brain and other vital organs, increase the level of systemic blood pressure, increase cardiac activity.

Some glands in our body perform a dual function, that is, they act simultaneously as glands of internal and external - mixed - secretion. These are, for example, the sex glands and the pancreas. The pancreas secretes digestive juice that enters the duodenum; at the same time, its individual cells function as endocrine glands, producing the hormone insulin, which regulates the metabolism of carbohydrates in the body. During digestion, carbohydrates are broken down into glucose, which is absorbed from the intestines into the blood vessels. A decrease in insulin production leads to the fact that most of the glucose cannot penetrate from the blood vessels further into the tissues of the organs. As a result, the cells of various tissues are left without the most important source of energy - glucose, which is eventually excreted from the body with urine. This disease is called diabetes. What happens when the pancreas produces too much insulin? Glucose is very quickly consumed by various tissues, primarily muscles, and the blood sugar content drops to a dangerously low level. As a result, the brain lacks "fuel", the person falls into the so-called insulin shock and loses consciousness. In this case, it is necessary to quickly introduce glucose into the blood.

The sex glands form sex cells and produce hormones that regulate the growth and maturation of the body, the formation of secondary sexual characteristics. In men, this is the growth of mustaches and beards, coarsening of the voice, a change in physique, in women - a high voice, roundness of body shapes. Sex hormones determine the development of the genital organs, the maturation of germ cells, in women they control the phases of the sexual cycle, the course of pregnancy.

The structure of the thyroid gland

The thyroid gland is one of the most important organs of internal secretion. The description of the thyroid gland was given back in 1543 by A. Vesalius, and it received its name more than a century later - in 1656.

Modern scientific ideas about the thyroid gland began to take shape by the end of the 19th century, when the Swiss surgeon T. Kocher in 1883 described signs of mental retardation (cretinism) in a child that developed after the removal of this organ.

In 1896, A. Bauman established a high content of iodine in iron and drew the attention of researchers to the fact that even the ancient Chinese successfully treated cretinism with the ashes of sea sponges containing a large amount of iodine. The thyroid gland was first subjected to experimental study in 1927. Nine years later, the concept of its intrasecretory function was formulated.

It is now known that the thyroid gland consists of two lobes connected by a narrow isthmus. Otho is the largest endocrine gland. In an adult, its mass is 25-60 g; it is located in front and on the sides of the larynx. The tissue of the gland consists mainly of many cells - thyrocytes, which combine into follicles (vesicles). The cavity of each such vesicle is filled with the product of thyrocyte activity - a colloid. Blood vessels adjoin the follicles from the outside, from where the starting substances for the synthesis of hormones enter the cells. It is the colloid that allows the body to do without iodine for some time, which usually comes with water, food, and inhaled air. However, with prolonged iodine deficiency, hormone production is disrupted.

The main hormonal product of the thyroid gland is thyroxine. Another hormone, triiodtyranium, is produced only in small quantities by the thyroid gland. It is formed mainly from thyroxine after the elimination of one iodine atom from it. This process occurs in many tissues (especially in the liver) and plays an important role in maintaining the hormonal balance of the body, since triiodothyronine is much more active than thyroxine.

Diseases associated with impaired functioning of the thyroid gland can occur not only with changes in the gland itself, but also with a lack of iodine in the body, as well as diseases of the anterior pituitary gland, etc.

With a decrease in the functions (hypofunction) of the thyroid gland in childhood, cretinism develops, characterized by inhibition in the development of all body systems, short stature, and dementia. In an adult with a lack of thyroid hormones, myxedema occurs, in which edema, dementia, decreased immunity, and weakness are observed. This disease responds well to treatment with thyroid hormone preparations. With increased production of thyroid hormones, Graves' disease occurs, in which excitability, metabolic rate, heart rate increase sharply, bulging eyes (exophthalmos) develop and weight loss occurs. In those geographic areas where water contains little iodine (usually found in the mountains), the population often has goiter - a disease in which the secreting tissue of the thyroid gland grows, but cannot, in the absence of the required amount of iodine, synthesize full-fledged hormones. In such areas, the consumption of iodine by the population should be increased, which can be ensured, for example, by the use of table salt with mandatory small additions of sodium iodide.

A growth hormone

For the first time, an assumption about the release of a specific growth hormone by the pituitary gland was made in 1921 by a group of American scientists. In the experiment, they were able to stimulate the growth of rats to twice their normal size by daily administration of an extract of the pituitary gland. In its pure form, growth hormone was isolated only in the 1970s, first from the pituitary gland of a bull, and then from horses and humans. This hormone does not affect one particular gland, but the entire body.

Human height is a variable value: it increases up to 18-23 years old, remains unchanged until about 50 years old, and then decreases by 1-2 cm every 10 years.

In addition, growth rates vary from person to person. For a “conditional person” (such a term is adopted by the World Health Organization when defining various parameters of life), the average height is 160 cm for women and 170 cm for men. But a person below 140 cm or above 195 cm is already considered very low or very high.

With a lack of growth hormone in children, pituitary dwarfism develops, and with an excess - pituitary gigantism. The tallest pituitary giant whose height was accurately measured was the American R. Wadlow (272 cm).

If an excess of this hormone is observed in an adult, when normal growth has already stopped, acromegaly disease occurs, in which the nose, lips, fingers and toes, and some other parts of the body grow.

Test your knowledge

1. What is the essence of humoral regulation of processes occurring in the body?
2. What glands are endocrine glands?
3. What are the functions of the adrenal glands?
4. List the main properties of hormones.
5. What is the function of the thyroid gland?
6. What glands of mixed secretion do you know?
7. Where do the hormones secreted by the endocrine glands go?
8. What is the function of the pancreas?
9. List the functions of the parathyroid glands.

Think

What can lead to a lack of hormones secreted by the body?

Endocrine glands secrete hormones directly into the blood - biolo! ic active substances. Hormones regulate metabolism, growth, development of the body and the functioning of its organs.