Glutamic acid - instructions, application, reviews. Glutamic acid - official * instructions for use

Glutamine is one of the amino acids that make up the proteins in our body. Our bodies synthesize it on their own, and it is also found in many foods in sufficient quantities. Its effect on the body is very diverse. It helps transmit signals to the brain through the nerves, it produces gamma-aminobutyric acid, which improves the blood supply to the brain. A derivative of glutamic acid (monosodium glutamate) is used as a flavoring agent - it gives the food a pleasant taste. Also, the amino acid neutralizes ammonia, a toxic substance formed during the breakdown of proteins. It turns into urea and is excreted from the body in the urine. Glutamine also helps the body to more easily endure psychological and physical stress, eliminates allergies and inflammation. This substance is very important for the functioning of the immune system.

Application of Glutamic Acid

Glutamic acid has found wide application in medicine. It is produced in the form of tablets, powder and granules for the preparation of a suspension and is used as a detoxifying and nootropic agent that stimulates metabolism in the central nervous system. Also, the amino acid is involved in protein and nitrogen metabolism and redox processes in the brain. It is prescribed in combination with other drugs for epilepsy, psychosis, schizophrenia, insomnia, depression, myopathy, consequences after meningitis, encephalitis, birth intracranial injury, Down's disease, cerebral palsy. Tablets should be taken 15-30 minutes before meals twice or thrice a day, 1 gram for adults, 0.5 g for children 7-9 years old, 0.4 g for children 5-6 years old, 0.15- 0.25 g - for children 1-4 years old. The course of treatment should last at least 1-2 months.

Glutamic acid in bodybuilding

Glutamic acid is necessary for every person and will be useful for representatives of any sport. With a high level of glutamine in the muscles, their performance and endurance increase and the time required for the muscles to recover after sports is reduced. When using glutamic acid, the body needs to expend less energy on the synthesis of amino acids. It also increases the nitrogen content in the body and the production of growth hormones. With a sufficient level of nitrogen, the aging process slows down. With a normal level of glutamine in the body, potassium ions penetrate the muscle cells more easily, which contributes to their better contraction and increased functionality. Often, the amino acid is combined with cystine and glycine to improve heart function, increase muscle endurance and normalize redox processes in the body.

Glutamic acid belongs to the group of non-essential amino acids and plays an important role in the body. Its content in the body is up to 25% of all amino acids.

On an industrial scale, glutamic acid is obtained by microbiological synthesis. In its chemically pure form, it has the appearance of white or colorless odorless crystals with a sour taste; the crystals do not dissolve well in water. For better solubility, glutamic acid is converted into sodium salt - glutamate.

The use of glutamic acid

In the food industry, glutamic acid is known as a food additive under the name E620. It is used as a flavor enhancer in a number of foods along with glutamic acid salts - glutamates.

Glutamic acid is added to semi-finished products, various fast food products, culinary products, broth concentrates. It gives the food a pleasant meaty taste.

In medicine, the use of glutamic acid has a slight psychostimulating, stimulating and nootropic effect, which is used in the treatment of a number of diseases of the nervous system.

The value of glutamic acid for the body

The role of glutamic acid is difficult to overestimate, it:

Participates in the synthesis of histamine, serotonin and a number of other biologically active substances;
Neutralizes the harmful decay product - ammonia;
Is a mediator;
Included in the cycle of transformations of carbohydrates and nucleic acids;
Folic acid is synthesized from it;
Participates in the exchange of energy with the formation of AFT in the brain.

In the body, glutamic acid is part of proteins, it is present in the blood plasma in a free form, and also as an integral part of a number of low molecular weight substances. The human body contains a store of glutamic acid, in case of its insufficiency, it first of all goes to where it is needed most.

Glutamic acid plays an important role in the transmission of nerve impulses. Binding it to certain receptors of nerve cells leads to excitation of neurons and acceleration of impulse transmission. Thus, glutamic acid performs neurotransmitter functions.

With an excess of this amino acid in the synapse, overexcitation of nerve cells and even their damage is possible, which leads to diseases of the nervous system. In this case, the protective function is assumed by glial cells that surround and protect neurons. Neuroglial cells absorb and neutralize excess glutamic acid in the brain and peripheral nerves.

Glutamine amino acid increases the sensitivity of muscle fibers to potassium by increasing the permeability of cell membranes for it. This microelement plays an important role in muscle contraction by increasing the strength of muscle contraction.

Glutamic acid in sports

Glutamic acid is a fairly common component of sports nutrition. This is a non-essential amino acid for the human body, and the transformation of other amino acids occurs precisely through the glutamine amino acid, which plays an integrating role in the metabolism of nitrogenous substances. If the body lacks some amino acid, it is possible to compensate for its content by converting from those amino acids that are in excess.

In the event that the physical load on the body is very high, and the intake of protein with food is limited or does not meet the needs of the body, the phenomenon of nitrogenous redistribution occurs. In this case, the proteins that make up the structure of internal organs are used to build skeletal and cardiac muscle fibers. Therefore, in sports, glutamic acid plays an indispensable role, because it is an intermediate step in the transformation of those amino acids that the body lacks.

The conversion of glutamic acid to glutamine in order to neutralize ammonia is one of its main functions. Ammonia is very toxic, but it is an invariable metabolic product - it accounts for up to 80% of all nitrogenous compounds. The greater the load on the body, the more toxic nitrogen decomposition products are formed. In sports, glutamic acid takes over the reduction of ammonia levels by binding it to the non-toxic glutamine. In addition, according to reviews, glutamic acid quickly restores the condition of athletes after the competition, as it binds excess lactate, which is responsible for the feeling of muscle pain.

In athletes with a lack of glucose levels at the time of intense physical activity, glutamic acid turns into an energy source - glucose.

According to reviews, glutamic acid is well tolerated, has no side effects and is completely harmless to the body. Studies have shown that 100 g of protein foods contain 25 g of glutamic acid. This amino acid is a natural component of animal food, and the negative reviews about glutamic acid are somewhat exaggerated.

Glutamic acid is a nootropic and detoxifying agent that affects protein metabolism, as well as brain metabolism. It is produced in the form of granules for the preparation of a solution for oral administration and enteric-coated tablets.

Pharmacological action of glutamic acid

Glutamic acid is a drug of the group of non-essential amino acids. It can be synthesized by the human body. Its synthesis takes place in the kidneys, liver, lungs and brain. Two other amino acids, isoleucine and valine, are required for the glutamine molecule to be formulated.

This tool takes an active part in the regulation of metabolic processes in the central nervous system, helps to bind ammonia. Glutamic acid is also an amino acid that plays the role of a neurotransmitter with high metabolic activity in the brain. It stimulates all redox processes and the metabolism of brain proteins, normalizes the metabolic process by changing the functional state of the endocrine and nervous systems.

The use of Glutamic acid affects the strength of the excitation process in the synapses of the central nervous system and removes excess ammonia. The active components of the drug are contained in myofibrils and are involved in the synthesis of acetylcholine, other amino acids, adenosine triphosphate and urea. Taking the drug promotes the transfer and maintenance of calcium in the brain at the required concentration, stimulates the normalization of the redox potential. Glutamic acid increases the body's resistance to hypoxia, binds the metabolism of carbohydrates and nucleic acids, normalizes the content of glycolysis in tissues and blood.

According to the instructions, Glutamic acid has a hepatoprotective effect on the body, inhibiting the ability of the stomach to secrete a secret.

Indications for the use of glutamic acid

The drug is recommended for use as part of complex therapy for epilepsy (the presence of small seizures with equivalents), psychosis (somatogenic, involutional, intoxication), schizophrenia, mental exhaustion, reactive depression, the consequences of encephalitis and meningitis, insomnia, progressive myopathy and depression.

The instructions for Glutamic acid also indicate that the remedy is useful in diagnosing mental retardation of various etiologies, cerebral palsy, with the consequences of intracranial birth injuries, poliomyelitis in any period, Down's disease.

The drug is indicated for use in the presence of symptoms of toxic neuropathy when taking isonicotinic acid hydrazines.

Method of application and dosage

Glutamic acid is taken orally at 1 g two to three times a day.

The dosage of medicine for children depends on age:

Up to 1 year - 100 mg;
From 1 to 3 years - 150 mg;
3-4 years - 250 mg;
5-6 years - 400 mg;
7-9 years - 750 mg;
Over 10 years old - 1 year.

With diagnosed oligophrenia - 150-200 mg. The course of treatment is from one to twelve months.

Glutamic acid should be taken 30 minutes before a meal. When symptoms of dyspepsia develop - after or during a meal.

Side effects of glutamic acid

In reviews of Glutamic acid, there are reports that allergic reactions, vomiting, nausea, diarrhea, pain in the intestines, and increased excitability may occur during or after taking the drug. With prolonged use of the drug, anemia, irritation of the oral mucosa, leukopenia, cracks in the lips, a drop in hemoglobin content in the body are possible.

Contraindications to the use of glutamic acid

Therapy with the drug is prohibited in the presence of such indicators as febrile syndrome, duodenal ulcer and stomach ulcer, renal and hepatic insufficiency, leukopenia, anemia, various psychotic reactions, depressed bone marrow hematopoiesis, obesity, nephrotic syndrome.

Overdose

Among the reviews of Glutamic acid, there is no information about an overdose of the drug.

Terms and conditions of storage

The medication should be stored in a dry, cool, dark place, out of the reach of children, at the optimum temperature - no more than 25⁰С. The shelf life of Glutamic acid is 4 years from the date of issue.

During therapy, it is necessary to conduct regular general clinical blood and urine tests.

Glutamic acid can also be used to reduce neurotoxicity following other drugs.

Hello, dear readers of the wonderful site Review about and actually my review. So I decided to share with you my experience of using one far from well-known drug, which is available in tablets - Glutamic acid. Nowadays, it is sold in a pharmacy, and is absolutely available to everyone, and it is cheap.

Personal experience

With Glutamic acid, I met two years ago, because for a very long period of time, I went in for sports, and tightened the whole body. I found them quite quickly, in one of the pharmacies of our city, and they are made in Ukraine, the Kyiv Vitamin Plant. I worked out for a long time, I got very tired, I didn’t have enough strength for my family, and then I decided to take them to improve recovery after training. When I bought them, I saw that they are available in blisters, they have 10 tablets each, and the color is light blue. And so I then began to take them at once, two things at a time, washed down with water. Due to the fact that they have a smooth surface, swallowing them comes out very easily. So I took it before meals and twice a day. Yes, indeed, after training, I was very tired before taking this medication, but somewhere in the second week, after using it, I felt that I was going home with ease, I didn’t fall on the sofa at home, but I did absolutely all the housework. My husband and children were surprised at me, because before I paid almost no attention to them, but I lived with the goal of having a beautiful body, and my husband likes it. Since then, I have been taking these miracle pills, but with intervals of several months, and I live an absolutely full life, while I practically do not get sick, thanks to the function of the drug, which also strengthens the immune system perfectly. Glutamic acid is completely harmless, so it can be consumed by almost all healthy people who have indications for it.

Literally three months ago, I read that these pills can be used to make a face mask, which has an excellent effect on it, having a moisturizing, rejuvenating effect, regenerates skin areas, and also has an anti-inflammatory effect and wound healing properties. Yesterday I did it for the first time, next time I will make a mask next week.

I make the mask like this: I take 5 tablets and crush them, using a wooden crush, pour a dessert spoon of water into it, look at the consistency so that there is gruel, drip a few drops of aloe juice from my flowerpot and apply it on my face. I wash it off after 15 minutes.

The main substance glutamic acid, plus additional additives, has a neotropic pharmacological effect.

used for cerebral palsy, with inhibition of mental development of various etiologies, after birth intracranial trauma, Down's disease, with poliomyelitis;

a drug is prescribed in medicine for signs of schizophrenia, as well as epilepsy, but only in the initial and weak stages;

with psychosis, depression, insomnia, encephalitis and meningitis - with their consequences;

with mental exhaustion, myopathy, in the progression stage;

used for neuropathy of toxic origin, which occurred after use, or during its isonicotinic acid derivatives;

Contraindications for use:

with increased excitability, the drug can not be taken;

contraindicated in febrile condition;

with violent mental reactions, it cannot be taken;

with oppression of hematopoiesis in the bone marrow;

with malfunctions in the work of the kidneys and liver;

with peptic ulcer;

contraindications is anemia;

obesity;

with nephrotic syndrome;

with hypersensitivity to this component;

More detailed information about the drug can be found in the instructions for use. I have no right to advise this drug, since it has both contraindications and side effects, and I just shared my experience of its use.

Video review

All(5)

active substance: 1 tablet contains L-glutamic acid 250 mg;

Excipients: microcrystalline cellulose, povidone, calcium stearate;

shell: film coating mixture Opadry II Blue: hypromellose, lactose monohydrate, polyethylene glycol, titanium dioxide (E 171), indigo carmine (E 132), quinoline yellow (E 104).

Dosage form. Film-coated tablets.

Basic physical and chemical properties: tablets of a round shape with a biconvex surface, film-coated blue.

Pharmacotherapeutic group. Drugs acting on the nervous system.

ATX code N07X X.

Pharmacological properties

Pharmacodynamics.

A non-essential amino acid that is involved in the processes of transamination of amino acids in the body, in protein and carbohydrate metabolism, stimulates oxidative processes, promotes the neutralization and removal of ammonia from the body, and increases the body's resistance to hypoxia. Promotes the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays an important role in the activity of skeletal muscles. Glutamic acid belongs to the neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.

Pharmacokinetics.

Glutamic acid is well absorbed when taken orally. It is rapidly eliminated from the blood, accumulating mainly in muscle and nervous tissues, in the liver and kidneys, and penetrates through the blood-brain barrier and cell membranes. Partially glutamic acid is transaminated during absorption to form alanine. Under the influence of the enzyme glutamate decarboxylase, it is converted in the brain into a mediator - gamma-aminobutyric acid.

About 4-7% of it is excreted in the urine unchanged, the rest is utilized in the process of metabolic transformations.

clinical characteristics.

Indications

Treatment of epilepsy, mainly small seizures with equivalents, somatogenic, involutional, intoxication psychoses, reactive states with symptoms of depression, exhaustion; with mental retardation in children, Down's disease, with cerebral palsy, poliomyelitis (acute and recovery periods), with progressive myopathy, to eliminate and prevent neurotoxic phenomena that may occur with the use of isoniazid and other drugs of the isonicotinic acid hydrazide group.

Contraindications

Feverish conditions, irritability, pronounced psychotic reactions, hepatic and / or renal failure, nephrotic syndrome, peptic ulcer of the stomach and duodenum, diseases of the hematopoietic organs, anemia, leukopenia.

Interaction with other drugs and other types of interactions.

Together with thiamine and pyridoxine (preparations of B vitamins), glutamic acid can be used to prevent and treat neurotoxic events caused by the patient's use of drugs of the GINK group (isonicotinic acid hydrazide, for example, ftivazid, isoniazid).

In myopathy and muscular dystrophy, Glutamic acid is effective in combination with pachycarpine or glycocol.

Application features

During treatment, it is necessary to systematically conduct a study of urine and blood. If side effects occur, it is recommended to reduce the dose of the drug.

Glutamic acid can also be used to relieve neurotoxic effects associated with taking other drugs.

After taking Glutamic acid, rinse your mouth with a weak solution of sodium bicarbonate.

The drug contains lactose, so it should not be prescribed to patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

Use during pregnancy or lactation.

This medicinal product should not be used during pregnancy or lactation.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms.

Given the possible effect of the drug on the nervous system, the drug should be used with caution when driving vehicles or working with other mechanisms.

Dosage and administration

Adults appoint a single dose of 1 g 2-3 times a day.

Single doses for children are: 3-6 years old - 250 mg, 7-9 years old - 0.5-1 g; from 10 years old - 1 year.

Multiplicity of reception - 2-3 times a day.

With oligophrenia - 100-200 mg per 1 kg of the patient's body weight for several months.

Take 15-30 minutes before a meal, with the development of dyspeptic phenomena - during or after a meal.

The course of treatment is from 1-2 to 6-12 months.

Children.

The drug should not be used in children under 3 years of age.

Overdose

May increase the manifestations of adverse reactions.

Treatment: symptomatic therapy, gastric lavage, the use of enterosorbents.

Adverse reactions

From the blood and lymphatic system: decrease in hemoglobin content, leukopenia. From the gastrointestinal tract: vomiting, diarrhea.

From the nervous system: headache, irritability, insomnia. From the immune system: allergic reactions, including rash, itching, flushing.

Best before date

Storage conditions

Store in original packaging at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

Package

10 tablets in blisters.

10 tablets in a blister, 3 blisters in a pack.

Manufacturer

JSC "Kyiv VITAMIN PLANT".

The location of the manufacturer and the address of the place of its activity.

04073, Ukraine, Kyiv, st. Kopylovskaya, 38.

Website: www.vitamin.com.ua.