Eco with mf with what attempt. Squid, shrimp and prostate massage

The need for in vitro fertilization is due to a number of reasons. It is logical that women who decide on the procedure or have already entered into the protocol have gone through a difficult path to the opportunity to have their own children. Fear, worries, intentions to find out what the eco statistic is like the first time, are quite justified. This is an instinctive desire. And although it is generally accepted that there are more chances for a successful result in the second and third attempts, pregnancy after the first in vitro fertilization is not uncommon.

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A noticeable trend towards an increase in the positive results of in vitro fertilization is primarily associated with the development of science in this area. And reproduction, and embryology, and gynecology - these industries have stepped far forward since the first eco was carried out.

When was the first eco? Officially, attempts to conceive a child outside the body of a woman began in 1944. But, only in 1973, for the first time, it was possible to cultivate the embryo and transfer it to the uterine cavity. Unfortunately, the attempt did not end in pregnancy, a miscarriage occurred. The first pregnancy and childbirth during in vitro fertilization occurred, after 5 years, in 1978. Then the first eco-girl, Louise Brown, was born.

Since that time, the number of children born after artificial insemination around the world has exceeded the figure of 5 million, and is growing relentlessly. This, of course, indicates that the efficiency of eco is increasing from year to year. But the question is rather controversial - to be glad that more women turn to reproductive specialists for help, or to be sad about the deterioration of reproductive health in general.

The success rate of IVF generally depends on the cause of infertility. An important factor is the one on whose side there is a decrease in fertility in a couple. In addition, there are a number of reasons that, to a certain extent, affect the result of the in vitro fertilization procedure.

Statistics and what affects it

Statistics is a kind of collective opinion of society, which should not be fully relied upon. In the case of artificial insemination, it is almost impossible to accurately determine the numbers that would indicate with certainty a specific result or its causes.

It does not take into account, and cannot take into account all the specifics of a particular woman, man, couple. There are simply numbers that show the big picture - the number of successful protocols out of the total.

In most cases, the percentage of successful IV does not mean an equal number of children born. Unfortunately, out of the total number of successful attempts, only 75-80% will end in childbirth.

On average, IVF ends with pregnancy for the first time in 35-40% of cases. This value, depending on which clinic the procedure is performed in, in which country, can, in turn, fluctuate greatly, and the percentage of successful IVFs on the first attempt is 15-60%.

The probability of pregnancy after IVF the first time, even in an absolutely healthy couple, if they undergo such a procedure for the sake of experiment, will not be 100%.

A large number of factors affect a successful protocol. The reproductive health of a couple is undoubtedly of paramount importance, but there is also a psychological component to the issue.

Possible reasons for failure

No statistics, doctor or clinic can give an unequivocal answer to the question of whether pregnancy will occur during IVF on the first attempt.

The main list of reasons why eco does not work the first time includes:

1. the cause and prescription of the infertility of the couple, while the male factor plays an important role;
2. the quality of the male ejaculate;
3. the age of the woman, the older the patient, the lower the ovulatory reserve, the quality of the eggs and, accordingly, the less chance;
4. professionalism of doctors who prepare the protocol. The positive results of IVF the first time largely depend on the right tactics;
5. no matter how it sounds, the irresponsibility of the woman herself. Most of the patients, undergoing artificial insemination for the first time, do not follow all the recommendations of a specialist, self-medicate, which leads to a failure of the protocol and successful embryo transfer ends in rejection.

Each of these reasons applies equally to the factors influencing and on the whole. If the causes of infertility are not treatable, then a second IVF is necessary, and there may be several such attempts. As stated earlier, the eco statistics from the second attempt are more positive. In fairness, it is worth noting that more than 6-7 attempts, in turn, reduce the chances of pregnancy.

In addition to the factors mentioned above, there are a number of other conditions that indicate what the success of eco depends on:

• lifestyle of a woman, the presence of bad habits;
• concomitant diseases not previously identified;
• how many embryos were transferred (in many cases, transferring 2 embryos gives a better chance);
• the quality of the resulting embryos;
• whether there was an injury during the embryo transfer and others.

Regarding the quality of the embryos, by and large, this factor follows from the previous ones - the age of the patient, prescription and the cause of infertility, and the difficult transfer - from the professionalism of doctors.

Chances

If within a year, after making the decision to have children, you cannot get pregnant on your own, you should not delay the visit to the doctor. The older the woman, the higher the likelihood of Down syndrome with IVF in the unborn child. Although with natural conception, it also increases with the age of the expectant mother.

What are the chances of getting pregnant with IVF? The possibility of getting pregnant with ART is quite high. Doctors today use many ways that increase. This includes laser hatching, ICSI, and pre-implantation diagnostics of the embryo, and, if possible, they try to cultivate embryos to the blastocyst stage. In addition, there is always the option of using donor eggs or sperm.

Current technologies, registered artificial insemination drugs and protocol options give a good chance of success with IVF with one ovary. The main thing is that there is a response to therapy, follicles and oocytes mature, gametes merge, embryos divide and take root. That is, if there are no hormonal causes, genetic pathologies or other serious causes of infertility, but only the results of some, for example, surgical interventions, then the probability of a successful protocol is slightly higher.

Moms who got pregnant after IVF claim that they intuitively knew about the successful protocol inside. This is another confirmation that a woman's positive attitude, her emotions are also important. For their part, doctors are doing everything possible for pregnancy to occur, but they cannot influence what lifestyle a woman professes - how she eats, smokes, drinks alcohol, and so on.

The statistics of in vitro fertilization protocols should not inspire a future woman that nothing will come of the first attempt. Even if there is only one chance in a thousand, you can get into it. Moms who succeeded in eco the first time are definitely happy already, but in case of failure, you should not give up. The next time, taking into account the errors of the failed protocol, everything will definitely work out.

Preparing for IVF is a long process. Given the fact that for couples who decide on this procedure, artificial insemination becomes, without exaggeration, the last hope, after numerous attempts to conceive a child and a long treatment, they have very high hopes for IVF. The more painful is the realization that the first attempt was unsuccessful. We hasten to reassure: this is exactly what happens in most cases. Why IVF fails the first time? Let's list the most common reasons.

With viral and bacterial infections, the likelihood of successful IVF is reduced

The older the woman, the less likely it is that the embryo will immediately take root, because fertility decreases with age - after 35 years, and especially after 38. During this period, success is no more than 15%, while for women aged about 30 years - 35% . Often the numbers are even lower; to determine potential fertility, there are special tests - for example, a reaction to clomiphene or a measurement of the third day, which assesses the level of FGS in the blood.

Poor embryo quality

There is no unified system for assessing the quality of embryos in the world, but, as a rule, the following parameters are used: - correct shape; - crushing speed (the higher it is, the better). An embryo that will be implanted in a woman should have 8 cells on the third day. As a rule, the transfer is carried out on the third day, with the exception of some cases (such as cryopreservation), when a five-day wait is advisable; - the absence of fragments. An embryo is considered unsuitable for replanting if the fragmentation is 50 percent or more.

Infectious and viral diseases

SARS and especially influenza have a negative impact on the reproductive system, since during the illness toxic substances are produced that affect, among other things, the uterine cavity. In addition, antibiotics are often used to treat these diseases. By themselves, when properly selected, they do not adversely affect fertility, but can become dangerous in combination with hormonal drugs.

Changes in the endometrium

In order for successful implantation to occur, and then for the development of the embryo, it is necessary that the endometrium be mature, of the required thickness and with a structure that meets the standards. It is generally accepted that before implantation, its thickness should be at least 7 millimeters. Usually this parameter is determined by ultrasound before the start of hormonal stimulation, so that the doctor can prescribe additional drugs that do not prevent the maturation of the follicles, but at the same time contribute to an increase in the thickness of the endometrium.

The wrong stimulation

The most important stage of in vitro fertilization is ovarian stimulation to increase the number of maturing follicles containing eggs. If the types or dose of drugs were chosen incorrectly, the goal will not be achieved: the number of follicles will remain minimal or their quality will be unsatisfactory.

Pathology of the fallopian tubes

Before the procedure, a special study is always prescribed to help identify diseases of the fallopian tubes. For example, one of them is hydrosalpinx, which is an accumulation of fluid as a result of inflammatory processes. Moreover, stimulation of ovulation before IVF is one of the factors that contribute to the growth of hydrosalpinxes.

When a married couple is not able to conceive a child naturally, but really wants to have a consanguineous heir, doctors advise her to use reproductive technologies. The most commonly used technology in this case is IVF. But before deciding to take such a responsible step, it is useful to find out how effective this technique is and what the consequences may be.

Statistics of successful IVF protocols on the first try

The following factors influence the success of in vitro fertilization:

• the age of the couple;
• causes of infertility, severity and who has the problem (both partners or only the spouse);
• the quality and quantity of eggs taken during the puncture;
• quality and quantity of seeds;
• the number of “good” embryos;
• duration of infertility;
• the state of the endometrium of the uterus at the time of replanting;
• number of failed attempts;
• clinic level;
• the correct choice of the protocol;
• the reasonableness of the choice and dosage of hormonal drugs;
• genetic factors;
• application of cryotechnology;
• use of donor material;
• use of ICSI;
• the presence of bad habits among partners and their lifestyle;
• chronic diseases and inflammatory processes in the female body.

For different age groups

The most important among the many factors on which the success of the IVF protocol depends is age. The older the female body becomes, the lower its fertility and the lower the likelihood of bearing a healthy child.

According to statistics, after the first procedure, pregnancy occurs:

• in 9% of patients older than 40 years;
• 27% - at the age of 35-40 years;
• 38% are under 35 years old.

In general, the relationship between the age of a woman and the successful birth of a child thanks to the IVF procedure looks like this:

For different countries of the world

The global average for successful IVF on the first try is 30-40 percent. But the rates can vary depending on the clinic and country, ranging from 10–15% to 45–60%.

USA. According to 2013 data, 175,000 artificial insemination procedures were performed during this period. Pregnancy was recorded in 63,000 patients, which means that the procedure was successful by 36%.

Did you know? In Israel, the in vitro fertilization technique has been carried out since 1980, so local specialists are considered the best in the industry.

Already in 2016, about 180,000 protocols were carried out (120,000 of the first). 35% were successful and they ended with the birth of healthy babies.

Israel. Now in this country the percentage of successful IVF is 45-47%.
Spain. Here they are also famous for good results, 43% (in 20%, pregnancy occurred on the first attempt). And in Barcelona this figure is 45%.

South Korea. The national average is 40%. If a foreign woman is at the appointment with specialists, then for her the probability of a successful outcome will be 50%.

Such a jump is explained by the availability of high-quality diagnostic equipment, so when a woman diagnosed with infertility is examined, it may turn out that her problem is not so critical or is completely absent.

Japan. In 2015, 424,200 protocols were performed in the country, of which 51,000 ended in successful delivery.

Poland. This country has the most successful IVF procedures in Europe (about 55%).
Turkey and Cyprus. Here the most loyal laws in relation to the status of the patient and his age. Cryoprotocols are 43% successful here, and intrauterine insemination - 17.9%.

Ukraine. There are about 40 centers specializing in artificial insemination in the country. Their specialists are able to provide a positive result from the first time in 35-40%.

Russia. The average statistics in the country is at the level of 55-60%. Of these, 35% of procedures are successful on the first try, 40% are successful on the second.

The probability of IVF on the second attempt

According to statistics, a healthy woman not older than 30 years old can become pregnant in 50% of cases after the second attempt of the IVF protocol. With age, this probability decreases.

Did you know? According to 1990 data« from a test tube» More than 20,000 children have been born in the world. In 2010, this figure increased to 4 million.

In patients over the age of 40, the chances of a successful outcome are only 10-20%. But in general, when conducting a second attempt at artificial insemination, the chances of success increase and most women become mothers on the second attempt.
There are reasons for this:

1. This is facilitated by the use of a cryoprotocol if embryos have been stored, since the best ones are always selected for freezing.
2. The repeated procedure, as a rule, exhausts the female body less, as it does not require additional stimulation - which means that the body has more strength left to bear the child.
3. Doctors can work out a plan of action more clearly, based on the unsuccessful result and on new tests.

Which IVF attempt is more likely to get pregnant

The fact of pregnancy after IVF is a purely individual phenomenon for each woman, because, as mentioned above, this is influenced by a number of factors.

Therefore, it cannot be said with certainty that you will have a successful first attempt, or that after one failure you will definitely succeed.

Of course, there are general indicators, we talked about them in the previous section - from them we can conclude that most often pregnancy occurs on the first or second attempt.
The more attempts, the lower the chance of success. But there are times when pregnancy occurred only after 10-12 transplants.

IVF in the natural cycle: statistics

When IVF is carried out in a natural cycle, ovarian stimulation is not carried out, therefore, one egg is obtained from the follicle, which has matured naturally.

For a woman's body, such a procedure is more acceptable, since hormonal preparations are not introduced, but at the same time, this affects success. According to statistics, during IVF in the natural cycle, the probability of pregnancy is 7-10%.

What are the chances of successful IVF with a donor egg

As a rule, a donor egg during artificial insemination is used if the patient's own reserve of germ cells has dried up. This happens with age, so a narrow audience of elderly patients is used to obtain statistical data. In their case, a successful result is guaranteed in 45.8%.

IVF children are infertile: truth or myth

This issue has become a concern for many women who plan to give birth to a "test tube" child after the appearance of a number of publications and television programs that speak negatively about the IVF procedure itself.

So far, scientists have not given an unambiguous answer to this question, although American experts refute the truth of the statement about the infertility of IVF children.

All this is due to the fact that no one specifically conducted research, since the method of artificial insemination has been widely used not so long ago, so there is no statistics. In addition, the audience for research has not yet been formed.

However, there is data on the fertility of the first two "test-tube" girls: both of them successfully became mothers in a natural way. So it can be assumed that there is no risk with female babies. As for boys, there is no data to confirm or refute the myth about them, but there are fears that infertility is possible.
This is due to the fact that a male infant can inherit from his father the cause of infertility, if he had it or was passed down through the generation through the male line.

That is: if the father of the child has reduced sperm motility, the baby may also have this ailment. But the causes of infertility can be inherited by those children who were conceived naturally.

IVF and cancer: statistics

Cancer is one of the possible complications after IVF. According to statistics, it occurs in 0.0001% of patients who have undergone IVF. According to other data, the borderline form of ovarian cancer occurred 4 times more often in such women compared to those who had a natural pregnancy.

The invasive form arose with the same frequency. Such statistics on the development of cancer does not mean that IVF was the cause of its appearance. Regarding breast cancer, there is also no consensus.

Video: does IVF cause cancer Australian scientists, after conducting a series of studies, determined that if in vitro fertilization was performed on women under 25 years of age, breast cancer occurred in them 55% more often than in women who became pregnant naturally. If the procedure was performed for women older than 38 years, then the likelihood of breast cancer was the same for both categories.

Austrian scientists have found that hormone-dependent cancer is 3% more common in women after IVF. At the same time, London-based experts claim that ovarian cancer after unsuccessful IVF occurs 35% more often than in those who did not perform it. And young patients usually suffer from the disease.

Important! The main thing is to remember that if there are prerequisites for the development of a neoplasm, it can appear both after IVF and after pregnancy in a natural way. Any pregnancy- it is a hormonal surge that can support growth and developmentNot only embryo, but also tumors, although this surge is more significant with IVF.

So, the relationship between oncology and IVF is not an easy question. It remains open for the reason that no one has yet established the cause of the pathology, so it is difficult to predict how the body of a particular patient will behave after the protocol.

Possible Complications

If, after replanting, the embryo takes root, then pregnancy occurs. However, it is necessary to consolidate the result, as well as make sure that there are no complications that often occur during such a procedure, because there is a serious interference in the work of the entire female body.

Any violation of the cycle can lead to negative consequences, so the expectant mother should be under the close supervision of a doctor and be prepared for the following problems:

• ovarian hyperstimulation (occurs due to stimulation of ovulation, manifests itself in 1.3% of cases, causes an increase in the size of the organ);
• bleeding or injury to the abdominal organs (usually occurs during egg retrieval);
• multiple pregnancy (occurs if more than one embryo was implanted, and 2 or more took root; the probability of this is 50%; often causes a miscarriage);
• frozen pregnancy (occurs in 10-15% in patients over forty);
• ectopic pregnancy (probability 2-3%);
• spontaneous interruption.

Most often, complications occur in the first trimester of pregnancy. When analyzing statistics on the success of IVF protocols, it should be remembered that they are all averages.

The final result will depend not only on the professionalism of the doctor and the level of the clinic, but also on the age of the woman, her history, as well as the history of her partner. According to static data, you can only choose a country and a clinic in which you will have a higher chance of success.

IVF from the first time: does it work?

This is the main worrying question that is asked to doctors at the first consultation in a reproductive clinic and is persistently discussed in many forums. I would like to say right away that the question is not formulated correctly. You need to ask - will IVF work out the first time for me or for our couple? So many factors, including the individual characteristics of the body and the state of health, form the likelihood of positive results on the first try.

Main factors:

1. Age.

It turns out that in women over the age of 35, the chances of a positive result the first time are reduced, and it decreases even more. This is one of the reasons for the age limit in indications for artificial insemination.

How can doctors help?

When conducting artificial insemination in order to increase the success of the doctor can:

• if violations in the body and reasons why it is impossible to carry out the procedure this month are detected, it is recommended to postpone IVF to one of the subsequent cycles;
• choose an individual stimulation scheme, special techniques and micromanipulations (ICSI,);
• use different environments to enhance

In today's world, many couples suffer from infertility. Most of them try to resort to the use of assisted reproductive technologies in general and in vitro fertilization in particular, and this is due to various reasons. Every woman who is preparing for the protocol or has begun its implementation is interested in what IVF statistics are from the first time, because on the way to the desire to become a mother she had to overcome various risks and fears.

In fertility clinics, doctors say that after the initial replanting of the embryo, it has a good chance of attaching to the uterine cavity. However, on an equal footing with this, those women who carry out the second or third protocol are more likely to become pregnant and give birth to a child. Let us consider in more detail how realistic it is to successfully pass IVF the first time and what can prevent this.

The very first experience of cultivation, fertilization and transfer of an embryo into the uterine cavity of a woman was at the end of the twentieth century. Unfortunately, IVF failed on the first attempt, and the pregnancy ended in spontaneous abortion and fetal rejection. Only in 1978 did the doctors succeed in the experience of in vitro fertilization, which ended with the birth of a healthy child.

Currently, worldwide the number of babies born after the implementation of assisted reproductive technologies reaches 5 million, and the number of children is increasing every year. Based on this, we can say that the statistics of IVF at the first attempt tends to improve.

Asking the question why IVF does not work the first time, the reasons for the inability to conceive a child naturally must be clarified first. Of course, the main factor that negatively affects the possibility of natural fertilization is the low level of fertility, but since initially we are talking about statistics, they should be given more attention.

Data

If you study the opinions expressed by couples who have used in vitro fertilization, you can also find reviews from the first time. IVF in a certain number of families with this attempt was still successful.

But all this should be combined into a certain collective aspect, which is statistics in general. Therefore, you should not clearly trust these data, because in each case the doctor will not be able to guarantee whether the protocol will be successful or not.

Currently, scientists in the field of reproductive medicine present the following IVF percentage from the first pregnancy, based on the age of the expectant mother:

1. Successful IVF from the first time in patients under 29 years of age is noted in 83% of cases;
2. In women aged 30 to 34, the chance of pregnancy drops to 61%;
3. In future mothers who are 35-39 years old, with IVF, the probability of pregnancy from the first time is only 34%;
4. When the protocol is implemented, women over 40 become pregnant only in 27%, and with the use of donor oocytes, the chances increase to 71%.

It is very important to understand that each patient has a good chance of getting pregnant the first time, IVF has recently developed quite well in terms of increasing the experience of doctors in this area. However, the procedure does not guarantee that after the embryo is attached, the woman will be able to bear the fetus and give birth to a child.

If we take all the successful protocols, combine them into a single one and define them as 100%, then delivery occurs only in 75-80% of women. In most cases, a positive IVF result from the first time is noted in only 35-40% of patients.

But even here the statistics are very different, depending on the professionalism of the doctor, the status of the clinic, the country of the procedure and the individual characteristics of the woman. It can be said that successful IVF on the first attempt has a percentage of 15 to 60. If we consider a perfectly healthy couple who, for the sake of the test, will be conceived by in vitro fertilization, then in this case the success of the procedure will not be 100%.

Reasons for failure

Many, of course, are interested in why IVF does not work the first time. The reasons for each infertile couple are completely different, however, doctors identify a number of the most common factors that do not allow pregnancy to occur after a single protocol, among them:

• How long has the couple been treated for infertility;
• Which factor prevails (male or female);
• Low quality of seminal fluid of the sexual partner;
• Ovulatory reserve (the older the woman, the less eggs are produced in her body, respectively, the probability of IVF decreases the first time);
• Practical experience of a reproductologist (if a specialist rarely performs such a procedure, then his percentage of successful IVF the first time is much lower);
• Non-compliance by a woman with medical recommendations in the first protocol is also the reason why IVF does not work the first time.

It cannot be unequivocally said that any given reason is in the first place of failures. All of them equally reduce the likelihood of a fertilized egg attaching to the uterine cavity.

Many couples also wonder if IVF did not work the first time, what to do next. Doctors advise, provided it is impossible to cure infertility, to carry out several more protocols of in vitro fertilization. It is important to understand that subsequent participation in the program significantly increases the chances of pregnancy, while if there are more than five protocols, then they, on the contrary, decrease.

The probability of successful IVF the first time is directly related to the following factors:

1. What lifestyle does a woman and her sexual partner lead;
2. Do future parents have bad habits (nicotine addiction, alcoholism, drug addiction, substance abuse is definitely why IVF did not work the first time);
3. The presence of concomitant diseases that have not previously been diagnosed by doctors;
4. Number of implanted embryos (successful IVF on the first attempt is possible if 2 or more embryos are transferred);
5. The level of quality and viability of the resulting embryos;
6. Whether there was an injury during the embryo transfer.

Doctors also note that the item related to the level of quality of the embryos themselves depends on other reasons (the age of the woman, how difficult the transfer was, etc.).

Why it doesn't work (video)

Chances

Doctors recommend that couples who have not been able to conceive a child naturally for a year should go to an appointment with a urologist and gynecologist as early as possible. The age of the future mother directly affects the health of the child. So experts note that regardless of the method of conception, women after 40 years of age are more likely to have children with Down syndrome.

Successful IVF the first time, the doctors' reviews confirm this, it happens not as rarely as it might seem at first glance. This is achieved thanks to the ability of doctors to use modern medical tools and procedures, such as pre-implantation diagnostics of the embryo, laser hatching, ICSI technique, cultivation of the embryo until it becomes a blastocyst.

Studying the reviews of IVF at the first attempt, you can see that when using donor sperm or oocytes, the likelihood of a successful pregnancy and subsequent birth increases significantly.

Women with only one functioning ovary can also count on a successful in vitro fertilization protocol. This is also made possible by a wide range of stimulant and supportive medicines.

Those patients who succeeded in IVF the first time, claim that they intuitively understood that the protocol would be successful. An important role in this is played not only by compliance with medical recommendations, but also by the positive mood of the future mother, maintaining the right lifestyle and avoiding stressful situations as much as possible.

Preparation rules

Almost every expectant mother who decides on in vitro fertilization thinks about how to prepare for IVF so that it works the first time. Often, this topic is quite clearly answered by doctors, in particular, a reproductologist who will implement the protocol.

First of all, you should provide the doctor with the most detailed information regarding the history of infertility. It is necessary to prepare the results of analyzes, ultrasound examinations and the conclusions of narrow specialists who examined the patient earlier.

If a reproductologist asks a question about the state of health or treatment methods, you need to give truthful answers, because the likelihood of pregnancy and subsequent childbirth directly depends on this. Immediately before the procedure, you need to find out from the doctor what time, and which vitamins should be taken to prepare the body.

The most important step is to cure all comorbidities, because they significantly reduce the likelihood of success in the first IVF protocol. The nutrition of the expectant mother must be correct. The maximum enrichment of the diet with fresh vegetables, fruits, wholesome food is the key to success.