How to give motilium to a 5 year old. Suspension Motilium for children - how and in what cases to use the medicine? What is a pharmaceutical agent Motilium

Thanks

Motilium represents antiemetic, which also has the ability to reduce the severity of dyspeptic symptoms (heartburn, flatulence, belching, nausea, vomiting, feeling of fullness and pain in the stomach after eating, etc.) due to impaired evacuation of the food bolus from the stomach to the intestines. Therefore, Motilium is used to stop vomiting, as well as alleviate dyspeptic symptoms in reflux esophagitis, gastroesophageal reflux, GERD, esophagitis, gastric hypotension, as well as against the background of cytostatic therapy or radiotherapy of tumors.

Release forms, names and composition of Motilium

Motilium is currently available in the following three dosage forms:
1. Tablets for resorption in the oral cavity;
2. Coated tablets for oral administration;
3. Suspension for oral administration.

Coated and oral lozenges are usually referred to simply as "Motilium tablets" without specifying which variety is being referred to. And the suspension is often called Motilium syrup in everyday speech. However, since Motilium does not exist in the form of a syrup, people use this term to refer to the liquid form of the drug, without going into the subtleties of the differences between suspension, solution, syrup, emulsion, etc. In addition, the suspension is often called children's Motilium, since it is this dosage form that is used in pediatric practice.

The composition of all dosage forms of Motilium as an active substance includes domperidone in the following different dosages:

Tablets for resorption in the oral cavity - 10 mg;
Tablets for oral administration in the shell - 10 mg;
Suspension - 1 mg per 1 ml.

Auxiliary components of all three dosage forms of Motilium are shown in the table.

Lozenges	Coated tablets	Suspension
Gelatin	Lactose	Saccharin sodium
Mannitol	Corn starch	Sorbitol
Aspartame	Potato starch	Sodium hydroxide
mint essence	Polividon	Polysorbate
Poloxamer 188		Microcrystalline cellulose
	magnesium stearate	Purified water
	Hydrogenated vegetable oil	Sodium carboxymethylcellulose
	Lauryl sulfate	Methyl parahydroxybenzoate
	Hypromellose	Propyl parahydroxybenzoate

The lozenges are round in shape and white or almost white in color. Coated tablets are round, white or off-white in color and marked "Janssen" and "M/10" on the flat surfaces. If the tablet in the shell is broken, then at the break it will be uniformly white, without inclusions. Both types of tablets are available in packs of 10 or 30 pieces.

The suspension is a white opaque liquid of a homogeneous structure and jelly-like consistency. Produced in dark glass bottles of 100 ml.

What helps Motilium (therapeutic effects)

Motilium has the following pharmacological effects:

Suppression of the activity of the vomiting center in the brain;
Increase in the intensity and duration of contractions of the stomach and duodenum;
Increased pressure in the esophagus;
Acceleration of the evacuation of the food bolus from the stomach into the duodenum.

These pharmacological effects provide a therapeutic effect of Motilium, which consists in stopping the symptoms of indigestion (flatulence, belching, feeling of heaviness and pain in the stomach after eating, nausea, vomiting, heartburn, etc.) caused by diseases of the stomach, in which the evacuation process is disturbed its contents (gastritis, peptic ulcer, reflux esophagitis, GERD, hypotension of the stomach), as a result of which food stagnates and does not pass into the duodenum in time.

Motilium improves the contractile activity of the stomach muscles, which leads to a faster evacuation of the food bolus into the duodenum. And due to the fact that food does not stagnate and does not irritate the stomach, a person experiences painful symptoms of dyspepsia (belching, heartburn, flatulence, etc.). That is, Motilium helps to get rid of the symptoms of stomach diseases, in which food stagnates in it. And since these symptoms can also occur in a healthy person, for example, when overeating, eating fatty or unusual foods, or with other violations of a normal balanced diet, Motilium will also help in this case to get rid of the discomfort associated with stomach overcrowding.

Due to the increase in pressure in the esophagus, Motilium prevents gastroesophageal reflux, reducing heartburn and other symptoms (sour belching, etc.), as well as helping to cure GERD (gastroesophageal reflux disease). That is, Motilium helps to stop the symptoms of gastroesophageal reflux and GERD.

And due to the suppression of the activity of the vomiting center, Motilium is able to eliminate vomiting provoked by an infectious disease, taking medications, various chronic pathologies of any organs and systems, as well as functional digestive disorders caused by the use of unknown or unusual food and other similar factors.

Motilium - indications for use

Suspension and both types of Motilium tablets are indicated for use in the following identical cases:
1. Relief of the following symptoms of hypotension of the stomach, gastritis, GERD, reflux esophagitis, gastroesophageal reflux arising from food retention in the stomach and its slow evacuation into the intestines:

Feeling of heaviness, pressure or fullness in the stomach after eating;
Pain in the stomach after eating;
Bloating
Belching, including sour contents;
Vomit;
Heartburn;
Regurgitation (throwing a fairly large amount of stomach contents into the oral cavity).

2. Nausea or vomiting caused by infectious diseases, pathologies of any internal organs, or functional disorders (for example, errors in diet, motion sickness, eating too much food at a time, etc.).
3. Nausea and vomiting provoked by medication, as well as radiotherapy and chemotherapy for tumors.

4. Nausea and vomiting provoked by taking Levodopa, Bromocriptine or other drugs of the dopamine agonist group in parkinsonism.
5. Relief of nausea and gag reflex during medical procedures, for example, the introduction of a gastric tube, the production of EFGDS, etc.
6. regurgitation syndrome in children.
7. Cyclic vomiting in children.
8. Gastroesophageal reflux in children.
9. Disorders of gastric motility in children.

Instructions for use

Consider the rules for using both types of Motilium tablets in one section, since they differ slightly. And we will consider the rules for using Motilium suspension in a separate section.

Motilium tablets - instructions for use

The absorbable and coated tablets should be taken 15 to 30 minutes before a meal. Also, if necessary, Motilium can be taken at bedtime.

The coated tablet is simply swallowed without biting or chewing with half a glass of water. A lozenge is placed on the tongue and wait a few seconds until it breaks up into small particles. After that, the formed particles are swallowed and, if necessary, washed down with a few sips of water. However, if for some reason there is no water, then absorbable tablets can not be washed down after they have disintegrated into small particles on the tongue and have been swallowed.

The coated tablets can be removed from the blister without any special precautions. And with absorbable tablets, care must be taken, as they are quite fragile. In order to avoid breaking and spilling the tablets, it is recommended not to squeeze them out of the blister through the foil, but to carefully cut the edge of the cell with scissors. You can also carefully remove the foil from one cell and remove the tablet from it.

To stop the manifestations of dyspepsia (belching, heartburn, flatulence, feeling of fullness in the stomach, etc.) in chronic diseases of the stomach and esophagus, adults and children over 5 years old should take 1 tablet 3 times a day before meals, and, if necessary, before sleep. If there is no effect, children over 12 years of age and adults can double the dosage, that is, take 2 tablets 3 times a day before meals.

With nausea and vomiting for their relief, children over 12 years of age and adults should take 2 tablets 3 to 4 times a day before meals and at bedtime. And for children 5-12 years old, for the relief of nausea and vomiting, 1 tablet 3-4 times a day before meals and at bedtime should be given.

For children 5-12 years old, the maximum allowable daily dosage of Motilium is 2.4 mg (1/4 tablet) per 1 kg of body weight, but not more than 80 mg (8 tablets). For adults and adolescents over 12 years of age, the maximum allowable daily dosage of Motilium is 80 mg.

For children under 5 years of age, the drug is given in the form of a suspension and the dosage is calculated individually according to body weight, based on the ratio of 2.5 ml per 10 kg of weight. Motilium tablets are not used in children under 5 years of age and weighing less than 35 kg.

Motilium suspension (Motilium for children) - instructions for use

The suspension is intended for use in children under 5 years of age and weighing less than 35 kg. In children of the first year of life, the drug should be used only as directed by a doctor and under constant supervision.

Suspension, as well as tablets, should be given to the child 15 to 30 minutes before meals and, if necessary, at bedtime. The amount of the drug, measured with a special syringe, must be poured into a spoon or into a small container (glass, glass, etc.) and given to the child to drink. You can drink the suspension as you wish.

The dosage of the suspension for use for various conditions in children is the same and depends only on body weight. The dosage each time is calculated individually according to the ratio of 0.25 - 0.5 ml of suspension for every 1 kg of the child's body weight. The calculated amount of suspension is given to the child 3-4 times a day before meals and, if necessary, at bedtime.

However, since a handy measuring syringe is supplied with the bottle, on which the options for the weight of the child in increments of 1 kg and the corresponding amount of suspension in ml are indicated at the same time, you can not calculate the dosage for the baby. Simply use the included measuring syringe.

The maximum allowable daily dosage of Motilium suspension for children under 5 years of age is 2.4 ml per 1 kg of body weight, but not more than 80 mg (80 ml of suspension).

If necessary, the suspension can be taken by both adults and adolescents over 12 years of age at a dosage of 10-20 ml 3-4 times a day. The maximum allowable daily dose of the suspension for adults and adolescents over 12 years of age is 80 ml.

Each time before use, shake the vial with the suspension, and then open it according to the following algorithm:
1. Press on the cover from above while turning it counterclockwise;
2. Remove cover;
3. Remove the measuring syringe from the package and lower it into the vial so that its tip goes into the suspension by 1-3 cm;
4. Holding the lower ring of the syringe with your fingers, raise the piston to a mark that corresponds to the weight of the child;
5. Holding the syringe by the lower ring, remove it from the vial;
6. Squeeze the suspension into a spoon or other container;
7. Rinse the syringe well with warm water after use;
8. Close the vial.

special instructions

Do not use Motilium for the relief and prevention of postoperative vomiting.

In renal insufficiency, it is recommended to maximize the intervals between two subsequent doses of the drug, but the dosage is not required to be reduced. However, if a person suffering from renal insufficiency must take Motilium for a long time, then the entire daily dosage should be divided into 1-2 doses, and not 3-4. If the kidney function worsens during the use of the drug, then it is necessary to reduce the dosage of the drug.

In case of liver failure, the drug in any form should be used with caution, constantly monitoring the functions and condition of the liver.

When using Motilium simultaneously with antacids (Renny, Phosphalugel, Almagel, Maalox, etc.) and H2-histamine blockers (Ranitidine, Famotidine, etc.), their intake should be spaced in time. It is optimal to take Motilium before meals, and antacids and H2-histamine blockers - after meals.

The coated tablets contain lactose, so they should not be taken by people suffering from milk sugar intolerance, as well as malabsorption of glucose and galactose. Also, lozenges should not be taken by people who have an increased risk of developing hyperphenylalaninemia due to their aspartame content.

In children under 1 year of age, Motilium in rare cases can provoke neurological side effects, therefore, when using the drug, one should strictly adhere to the recommended dosages, without increasing them on their own.

Use during pregnancy and breastfeeding

During pregnancy, Motilium can be taken only if the intended benefit to the mother outweighs the possible risks to the fetus. When breastfeeding, Motilium should not be taken, since the drug is in milk at a concentration of 50% of that in the blood.

Influence on the ability to control mechanisms

Motilium does not affect a person's ability to control mechanisms, therefore, against the background of the use of the drug, you can engage in any type of activity that requires a high concentration of attention and speed of reactions.

Overdose

An overdose of Motilium is possible and is manifested by the following symptoms:

Disorientation;
Agitation (excitement);
Altered consciousness;
Extrapyramidal reactions (tremor, speech disorder, tics, myoclonus, etc.).

For the treatment of overdose, a single gastric lavage is performed, followed by the intake of a sorbent (activated carbon, Polysorb, Polyphepan, etc.). In the future, if necessary, antihistamine and cholinergic drugs, drugs for the treatment of parkinsonism are used to stop extrapyramidal reactions.

Interaction with other drugs

Reduce the severity of the therapeutic effect of Motilium anticholinergics (Aprofen, Atropine, Scopolamine, Dicyclomine, Cyclizine, Benaktizin, etc.), Cimetidine and sodium bicarbonate. Enhance the action of Motilium Fluconazole, Itraconazole, Ketoconazole, Coriconazole, Clarithromycin, Erythromycin, Amprenavir, Atazanavir, Fosamprenavir, Indinavir, Nelfinavir, Ritonavir, Saquinavir, Diltiazem, Verapamil, Amiodarone, Aprepitant, Nefazodone and Telithromycin.

Ketoconazole and Erythromycin, when used simultaneously with Motilium, cause ECG changes that normalize after discontinuation of the drugs.

Side effects of Motilium

Suspension and both varieties of Motilium tablets can cause the same following side effects from various organs and systems:
1. Gastrointestinal tract:

Spasms of the intestines;
Changes in the activity of AsAT, AlAT and alkaline phosphatase;
Thirst;
Appetite disturbance.

2. Nervous system:

Extrapyramidal syndrome (tics, tremor, speech disorder, parkinson-like movements, muscle tone disorders, etc.);
convulsions;
Drowsiness;

3. Mental disorders:

Agitation (excitement);

4. The immune system:

Anaphylactic reactions (Quincke's edema, anaphylactic shock, urticaria);
Allergic reactions.

5. Endocrine system:

An increase in the level of prolactin in the blood;
Galactorrhea (leakage of milk from the breast);

6. Skin covers:

Extrapyramidal disorders, as a rule, occur in children, but are transient, that is, they disappear on their own after the end of Motilium intake and do not require special treatment.

Contraindications for use

Suspension and both varieties of Motilium tablets are contraindicated for use if a person has the following diseases or conditions:

Prolactinoma (a tumor of the pituitary gland of the brain that produces prolactin);
Hyperprolactinemia (increased levels of prolactin in the blood);
Simultaneous administration of drugs containing ketoconazole, erythromycin, fluconazole, voriconazole, clarithromycin, amiodarone or telithromycin as active substances;
Gastrointestinal bleeding;
Mechanical obstruction of the intestine;
Perforation of any organ of the digestive tract;
Body weight less than 35 kg (for tablets);
Individual sensitivity or intolerance to the components of the drug;
Pregnancy and lactation.

In children under 1 year of age, Motilium should only be used in the form of a suspension and with caution.

Motilium - analogues

On the pharmaceutical market, Motilium has analogues and synonyms. Synonyms are products containing, like Motilium, domperidone as an active substance. Analogues are medicines containing other active substances, but having the most similar spectrum of therapeutic action.

Synonyms of Motilium are the following drugs:

Damelium tablets;
Domet tablets;
Domperidone, Domperidone Geksal and Domperidone-Teva tablets;
Domstal tablets;
Motiject tablets;
Motilac lozenges and film-coated tablets;
Motinorm syrup and tablets;
Motonium tablets;
Passagex tablets are chewable and coated.

Analogues of Motilium are the following drugs:

Aceclidine solution for subcutaneous injection;
Ganaton tablets;
Dimetpramide tablets and solution for intramuscular injections;
Itomed tablets;
Itopra tablets;
Melomide hydrochloride tablets and solution for intravenous and intramuscular injections;
Metoclopramide tablets and solution for intravenous and intramuscular injections;
metoclopramide-acry tablets;
Metoclopramide-Vial, Metoclopramide-Promed, Metoclopramide-ESCOM solution for intravenous and intramuscular injections;
Perinorm tablets, oral solution and solution for intravenous and intramuscular injections;
Ceruglan tablets and solution for intravenous and intramuscular injections;
Cerucal tablets and solution for intravenous and intramuscular injections.

Cheap analogues

Among the synonyms of Motilium, the cheapest drugs are the following:

Domet - 76 - 108 rubles;
Domperidone - 99 - 113 rubles;
Passazhiks - 84 - 107 rubles;
Motilak - 126 - 232 rubles;
Motonium - 94 - 100 rubles.

Among the analogues of Motilium, the cheapest drugs are the following:

Dimetpramide - 89 - 168 rubles;
Metoclopramide 35 - 135 rubles;
Perinorm 99 - 183 rubles;
Tseruglan 19 - 42 rubles;
Cerucal 125 - 142 rubles.

Russian analogues of Motilium

Synonyms and analogues of Motilium produced by Russian pharmaceutical plants are shown in the table.

Reviews

Reviews on the use of Motilium in adults in most cases are positive, due to the high effectiveness of the drug when taken according to indications. However, in the reviews, not everything is unambiguous and there are a large number of nuances, since the range of conditions under which people took Motilium is quite wide and varied.

So, adults took Motilium in two main cases. First, the drug was taken episodically to relieve nausea and vomiting that arose due to existing diseases of the digestive tract, dietary disorders, or an infectious disease. Secondly, adults took Motilium as part of the complex therapy of stomach diseases (gastritis, peptic ulcer, pyloric stenosis, etc.), reflux and GERD in order to relieve flatulence, a feeling of fullness in the epigastrium, belching, early satiety, vomiting and other symptoms of the disorder. digestion of food, characteristic of these diseases.

With occasional use of Motilium to stop vomiting and nausea, the drug eliminates these symptoms in about 2/3 cases after the first pill. Stopping vomiting and nausea significantly improves a person’s general well-being, allowing him to calmly drink various solutions to replenish fluid loss, as well as take other medications, the action of which is aimed at eliminating the cause of symptoms and treating the disease. In such situations, reviews of Motilium were positive.

In the remaining 1/3 of cases, people had to take Motilium to stop vomiting for several days in a row before each meal or liquid. This mode of using the drug, of course, does not please people, therefore, in such situations, as a rule, they leave a neutral or negative review.

And when taking Motilium to relieve dyspeptic symptoms (belching, nausea, vomiting, flatulence, feeling of stomach fullness, epigastric pain, etc.), characteristic of chronic stomach diseases, GERD and reflux, the drug was effective in almost 100% of cases, Therefore, this category of reviews about him is almost all positive.

Motilium for children - reviews

Currently, there is a very interesting situation when, in practice, Motilium is used in children for a wide range of different conditions, and very often not according to indications, but according to their own ideas about the physiological functions of the child's body. Naturally, in such a situation, reviews of Motilium are very diverse. To navigate them, consider the reviews of people who gave the drug to a child for various reasons.

Reviews on the use of Motilium for the relief of vomiting in children with rotavirus infections, any other acute infectious diseases, as well as in response to medication in about 2/3 of cases, are positive. This is due to the fact that the drug stopped vomiting and improved the general condition of the child, who began to actively play, ask for drink, eat, etc. Moreover, in some cases, a single dose of the drug was enough to stop vomiting, and in others, it was necessary to give the child syrup several times a day for 2 to 3 days. When vomiting did not stop after a single dose of the drug, then the parents gave Motilium to the child before each meal, drink or other medication.

Approximately 1/3 - 1/4 reviews of Motilium for the relief of vomiting in acute conditions in children are negative, which, as a rule, is due not so much to the properties of the drug as to a subjective attitude towards it, high expectations, and also use not according to indications. Very often, parents try to give their child Motilium with vomiting provoked by poisoning, and when the drug does not have the expected effect, they are disappointed and leave negative feedback. In fact, Motilium will not stop vomiting in case of poisoning, since it is due to the entry of toxic substances into the blood from the intestine, and not a disorder of the stomach. In such cases, you need to take sorbents that bind toxic substances. And Motilium can be drunk only before taking the sorbent, so that the child does not vomit within the next 10-15 minutes and the main therapeutic drug is not brought out.

The second part of the reviews about Motilium concerns its use in infants and young children in order to reduce gas formation, bloating and regurgitation. In this case, almost all reviews of the drug are positive, since the syrup effectively stopped these symptoms.

The third part of the reviews about the drug concerns its use in diseases of the digestive tract in children (GERD, gastritis, gastroduodenitis, esophagitis, reflux) in order to relieve the unpleasant symptoms of slow gastric emptying (feelings of heaviness in the stomach, abdominal pain, belching, flatulence, nausea, vomiting and etc.). This category of reviews is in most cases positive, since parents achieve a good therapeutic effect with regular use of Motilium syrup according to the instructions.

The fourth part of the reviews about Motilium concerns its use not according to indications. So, many parents give syrup to children so that the food from the stomach is evacuated faster, and they can eat more at a time. This use of the syrup is based on the fact that Motilium stops the feeling of fullness in the stomach. Usually, the drug is used in this way when trying to make the child "eat well" and gain weight, which, according to parents and doctors, is insufficient. Naturally, such a method of improving the child's appetite and increasing the amount of food he eats does not work for a number of reasons, and parents leave a negative review about the drug.

Firstly, Motilium reduces the feeling of fullness in the stomach and accelerates the passage of the food bolus into the intestines only in diseases such as peptic ulcer, gastritis, GERD, esophagitis and reflux! And if the child does not suffer from such diseases, then his food is evacuated from the stomach to the intestines at a normal rate, and attempts to reduce this period of time only lead to the fact that the food bolus is poorly processed and digested by gastric juice. This will cause colic, flatulence, bloating and other discomfort in the baby. In other words, by trying to speed up the evacuation of the food bolus from the stomach to the intestines in order to “make room” for another large portion of food, parents only disrupt the normal process of digestion in a child, which can ultimately cause the development of severe chronic diseases of the gastrointestinal tract.

Secondly, while taking Motilium, the child will not be able to eat more, but, on the contrary, will be saturated with a smaller amount of food. This is due to the fact that the food bolus will quickly enter the intestines, from where the nutrients will begin to be absorbed into the bloodstream and give a signal to the brain about the onset of satiety. As a result, the child will be satisfied with much less food than before.

That is, the use of Motilium in order to "improve" the child's nutrition is not only irrational, inexpedient, ineffective and not according to indications, but also dangerous. In order for the child to gain weight, you need to feed him small portions of high-calorie and tasty food 4 to 6 times a day. And trying to feed him a large portion of low-calorie food only stretches the stomach, disrupts the normal process of digestion and creates the basis for the development of gastrointestinal diseases.

Ganaton or Motilium?

Ganaton is a prokinetic drug, that is, it improves the motor function of the stomach, accelerating the evacuation of its contents and, thereby, stopping the painful symptoms associated with food retention in it (heartburn, belching, flatulence, feeling of fullness and pain in the stomach, etc. .). And Motilium can be used for the same conditions as Ganaton, but also for stopping vomiting. That is, the spectrum of indications of Motilium overlaps that of Ganaton. However, the effectiveness of Ganaton is 10% higher compared to Motilium.

This means that for the relief of painful symptoms (nausea, vomiting, heartburn, belching, feeling of fullness and pain in the epigastrium, etc.) of diseases of the stomach and esophagus (gastritis, esophagitis, GERD, peptic ulcer, etc.), both Ganaton and and Motilium. However, Ganaton is preferable in such situations, since this drug is intended specifically for use in the complex therapy of these conditions.

Ganaton is also preferable in cases where it is necessary to take drugs for a long period of time or in conjunction with other drugs. This is usually necessary in the treatment of chronic diseases of the stomach and esophagus.

For episodic relief of symptoms of dyspepsia (heartburn, belching, vomiting, nausea, a feeling of fullness in the stomach, epigastric pain after eating, etc.) arising from a violation of the diet or for other reasons, you can use any drug that, for any reasons a person likes it more.

To stop vomiting and nausea caused by taking any medications, infections, gastrointestinal diseases and functional digestive disorders, Motilium should be chosen, since Ganaton is ineffective in such situations.

Motilium should also be chosen if it is necessary to use drugs with similar properties in children, since Ganaton cannot be used to treat babies.

Motilium or Motilac?

Motilium and Motilac are synonyms, that is, they contain exactly the same active ingredient domperidone. In terms of therapeutic effects, Motilac and Motilium do not differ from each other, however, the first drug causes side effects more often.

Thus, in the absence of any special requirements for the drug, as well as with overall good drug tolerance, when side effects are rare, you can choose any remedy - Motilak or Motilium, based only on subjective preferences (for example, for some reason like one drug more than another, relatives or friends respond positively). If a person is prone to the development of side effects or does not tolerate any medication, then Motilium should be preferred.

However, Motilium is available in tablets and suspensions, and Motilac is available only in tablets. Therefore, Motilac cannot be used for children, but Motilium can. That is, if it is necessary to use the remedy in children or in people who for some reason find it difficult to swallow tablets, Motilium should be preferred. If a person can take pills, then you can choose any remedy based on your own subjective preferences.

Motilium (tablets and suspension) - price

The cost of various dosage forms of Motilium varies in pharmacies of Russian cities within the following limits:

Suspension 1 mg / ml, bottle 100 ml - 485 - 672 rubles;
Lozenges 10 mg, 10 pieces - 345 - 458 rubles;
Lozenges 10 mg, 30 pieces - 550 - 701 rubles;
Coated tablets 10 mg, 30 pieces - 452 - 589 rubles.

Before use, you should consult with a specialist.

Motilium is a centrally acting antiemetic that blocks dopamine receptors.

Release form and composition

Film-coated tablets: round, biconvex, from pure white to pale cream color, on one side the inscription "JANSSEN", on the other - "M / 10" (10 or 30 pieces in a blister, in a carton box 1 blister );
Suspension for oral administration: homogeneous consistency, white (100 ml in dark glass bottles, in a cardboard box 1 bottle complete with dosing syringe).

The active substance is dromperidone: in 1 tablet - 10 mg, in 1 ml of suspension - 1 mg.

Additional components of tablets:

Excipients: hydrogenated cottonseed oil, pregelatinized starch, microcrystalline cellulose, polyvidone (K-90), corn starch, sodium lauryl sulfate, lactose monohydrate, magnesium stearate;
The composition of the film shell: sodium lauryl sulfate, hypromellose 2910 5 mPa × s, purified water.

Additional suspension components: non-crystallized liquid sorbitol 70%, propyl parahydroxybenzoate, polysorbate 20, sodium saccharinate, sodium hydroxide, methyl parahydroxybenzoate, microcrystalline cellulose and sodium carmellose, water.

Indications for use

Motilium is used for a complex of dyspeptic symptoms often associated with gastroesophageal reflux, esophagitis and delayed gastric emptying:

Early satiety, pain in the upper abdomen, a feeling of fullness in the epigastrium, a feeling of bloating;
Nausea, vomiting;
Flatulence, belching;
Heartburn and belching, including with gastric contents.

In addition, Motilium is used for nausea and vomiting caused by a violation of the diet or drug therapy, as well as infectious, organic or functional origin.

A specific indication for the use of Motilium is nausea and vomiting associated with dopamine agonists (such as bromocriptine and levodopa) in Parkinson's disease.

Contraindications

Absolute:

Prolactinoma (prolactin-secreting pituitary tumor);
Impaired liver function of moderate and severe degree;
Conditions in which stimulation of the motor function of the stomach is contraindicated, for example, mechanical obstruction, perforation, gastrointestinal bleeding;
Simultaneous use of oral forms of erythromycin, ketoconazole and other strong inhibitors of the CYP3A4 isoenzyme that cause prolongation of the QT interval, such as clarithromycin, voriconazole, amiodarone fluconazole, and telithromycin;
Lactose intolerance, galactosemia, glucose / galactose malabsorption - for tablets;
Body weight in children less than 35 kg - for tablets;
Hypersensitivity to the components of Motilium.

Relative (care should be taken because of the risk of complications):

Violation of conduction and heart rhythm, including prolongation of the QT interval;
Impaired kidney function;
congestive heart failure;
Electrolyte imbalances.

Method of application and dosage

Motilium should be taken orally, preferably before meals, because. food slows down the absorption of domperidone.

Coated tablets

Adults and adolescents over 12 years old: 1-2 tablets 3-4 times a day (no more than 8 tablets / day);
Children weighing more than 35 kg: 1 tablet 3-4 times a day. If the desired effect is absent, the dose is increased, but not more than 80 mg of domperidone per day.

Suspension for oral administration

Adults, adolescents over 12 years of age and children weighing more than 35 kg: 10-20 ml 3-4 times a day, but not more than 80 ml;
Infants and children under 12 years old: 0.25-0.5 ml per kilogram of body weight 3-4 times a day. The maximum allowable daily dose is 2.4 ml / kg, but not more than 80 mg. For ease of dosing, a scale with marks of the child's weight is applied on the syringe - from 0 to 20 kg.

Immediately before taking the vial should be gently shaken, mixing its contents well.

Rules for the use of the suspension:

Pressing on top of the plastic cover, turn it counterclockwise and remove;
Place a syringe into the vial;
While holding the lower ring in place, raise the upper ring to the mark corresponding to the child's weight (in kilograms);
Holding the lower ring, remove the filled syringe from the vial;
Close the vial;
After taking the drug, rinse the syringe with water.

Side effects

In general, Motilium is well tolerated. In rare cases, the following side effects occur:

Digestive system: gastrointestinal disorders, impaired liver function tests, transient intestinal spasms;
Nervous system: convulsions, headache, drowsiness, extrapyramidal phenomena (in children - rarely, in adults - in isolated cases; completely reversible, disappear on their own after discontinuation of the drug);
Mind: nervousness, agitation;
Immune system: allergic and anaphylactic reactions;
Endocrine system: an increase in the level of prolactin in the blood plasma, in some cases contributing to the appearance of neuro-endocrine phenomena (amenorrhea, gynecomastia, galactorrhea);
Skin: itching, rash.

special instructions

Patients with renal insufficiency do not need dose adjustment, however, with repeated use of Motilium, the frequency of administration should be reduced to 1-2 times a day. In some cases, a reduction in the single/daily dose is also indicated. If long-term treatment is necessary, the patient's condition should be constantly monitored.

In rare cases, the drug may cause neurological side effects in children. For this reason, it is important to adhere to the recommended dose.

In the case of the simultaneous appointment of antisecretory or antacid drugs, they must be taken after meals.

Motilium does not adversely affect attention and reaction speed.

drug interaction

The bioavailability of Motilium, taken orally, is reduced in the case of prior administration of sodium bicarbonate or cimetidine.

At the same time, antisecretory and antacid drugs should not be taken, because. they reduce the bioavailability of domperidone.

Anticholinergic drugs can neutralize the effect of Motilium.

Drugs that significantly inhibit the CYP3A4 isoenzyme may increase the plasma concentration of domperidone. These include azole antifungals (eg, ketoconazole*, itraconazole, voriconazole*, fluconazole*), macrolide antibiotics (eg, erythromycin*, clarithromycin*), HIV protease inhibitors (eg, indinavir, fosamprenavir, nelfinavir, atazanavir, ritonavir, amprenavir, saquinavir ), calcium antagonists (verapamil, diltiazem), amiodarone*, nefazodone, aprepitant, telithromycin. Drugs marked with an asterisk (*) also prolong the QTc interval.

Motilium has a gastrokinetic property, so it is expected that it may affect the absorption of concomitantly used oral preparations, in particular enteric-coated and sustained-release agents. However, the use of domperidone by patients during the period of use of digoxin or paracetamol did not affect the level of these drugs in the blood.

If necessary, Motilium can be used simultaneously with antipsychotic drugs (it does not enhance their effect), as well as with dopamine receptor agonists (levodopa or bromocriptine) - domperidone suppresses their peripheral effects (nausea, vomiting, digestive disorders), but does not affect the central action.

Terms and conditions of storage

Store at a temperature of 15-30 ° C, out of the reach of children.

Shelf life - 5 years.

Found a mistake in the text? Select it and press Ctrl + Enter.

A drug: MOTILIUM ® (MOTILIUM ®)

Active ingredient: domperidone
ATX code: A03FA03
KFG: Centrally acting antiemetic drug that blocks dopamine receptors
ICD-10 codes (indications): K20, K21, K30, R10.1, R11, R12, R14
Reg. number: P N014062/01
Date of registration: 19.11.08
The owner of the reg. acc.: JOHNSON & JOHNSON (Russia) produced by JANSSEN PHARMACEUTICA (Belgium)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Suspension for oral administration uniform, white.

Excipients: microcrystalline cellulose and sodium carmellose, non-crystallized liquid sorbitol 70%, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium saccharinate, polysorbate 20, sodium hydroxide, water.

100 ml - dark glass bottles (1) complete with dosing syringe - packs of cardboard.

INSTRUCTIONS FOR USE FOR THE SPECIALIST.
The description of the drug was approved by the manufacturer in 2013.

PHARMACHOLOGIC EFFECT

Antiemetic, central blocker of dopamine receptors. Domperidone is a dopamine antagonist with antiemetic properties. Domperidone does not penetrate well through the BBB. The use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. The antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone.

When taken orally, domperidone increases the duration of antral and duodenal contractions, increases pressure in the esophagus and accelerates gastric emptying in healthy people.

Domperidone has no effect on gastric secretion.

PHARMACOKINETICS

Suction

After oral administration on an empty stomach, domperidone is rapidly absorbed from the gastrointestinal tract. C max in blood plasma is reached within about 30-60 minutes. The low absolute oral bioavailability of domperidone (approximately 15%) is due to extensive primary metabolism in the intestinal wall and liver.

Although the bioavailability of domperidone is increased in healthy individuals when taken after meals, patients with gastrointestinal complaints should take domperidone 15-30 minutes before meals. Hypoacidity of gastric juice reduces the absorption of domperidone.

When taking the drug after a meal, it takes longer to reach C max, and the AUC increases slightly.

Distribution

When taken orally, domperidone does not accumulate and does not induce its own metabolism. After taking domperidone for 2 weeks at a dose of 30 mg / day, Cmax in blood plasma 90 minutes after the last dose was 21 ng / ml and was almost the same as after the first dose (18 ng / ml).

Plasma protein binding - 91-93%.

Metabolism

The drug is metabolized in the liver by hydroxylation and N-dealkylation. In in vitro drug metabolism studies using diagnostic inhibitors, it was found that CYP3A4 is the main isoenzyme of the cytochrome 450 system involved in the process of N-dealkylation of domperidone, while CYP3A4, CYP1A2 and CYP2E1 are involved in the process of aromatic hydroxylation of domperidone.

breeding

Excretion in urine and feces is 31% and 66% of the dose, respectively.

Excreted unchanged in feces (10%) and urine (approximately 1%).

T 1/2 from blood plasma after taking a single dose in healthy volunteers is 7-9 hours.

Pharmacokinetics in special clinical situations

In patients with severe renal insufficiency T 1/2 domperidone increases.

INDICATIONS

A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis:

Feeling of fullness in the epigastrium, early satiety, feeling of bloating, pain in the upper abdomen;

Belching, flatulence;

Nausea, vomiting;

Heartburn, belching with or without stomach contents.

Nausea and vomiting of functional, organic, infectious origin, caused by radiotherapy, drug therapy or dietary disorders. A specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson's disease (such as levodopa and bromocriptine).

DOSING MODE

Adults and adolescents over 12 years of age and weighing more than 35 kg appoint 10-20 ml of suspension 3 or 4 times / day, the maximum daily dose is 80 ml.

Children, incl. babies, appoint 0.25-0.5 mg of domperidone (0.25-0.5 ml of suspension) per 1 kg of body weight 3 or 4 times / day. The maximum daily dose is 2.4 mg per 1 kg of body weight, but not more than 80 mg / day. To determine the dose, use the child's body weight scale "0-20 kg" on the syringe.

At kidney failure single dose adjustment is not required. When re-appointment, the frequency of administration should be reduced to 1 or 2 times / day, depending on the severity of the insufficiency, and it may also be necessary to reduce the dose. With long-term therapy, patients should be monitored regularly.

Suspension application rules

Shake the suspension vial before use. The suspension is supplied in a package protected from accidental opening by children. The vial should be opened in the following way: press down on the plastic cap of the vial while turning it counterclockwise; remove the screwed cover.

Then the syringe should be placed in the vial. While holding the lower ring in place, raise the upper one to the mark corresponding to the child's body weight (kg). Holding the bottom ring, pull the filled syringe out of the vial. Empty the syringe. Close the vial. Rinse the syringe with water.

SIDE EFFECT

Side effects are given with distribution by frequency and organ systems. The frequency of side effects was classified as follows: very often (> 1/10), often (> 1/100,<1/10) и нечасто (>1/1000, <1/100), редко (>1/10 000, <1/1000) и очень редко (<1/10 000, включая отдельные случаи).

From the digestive system: rarely - gastrointestinal disorders; very rarely - transient spasms of the intestine.

From the nervous system: very rarely - extrapyramidal syndrome, convulsions, drowsiness, headache. Extrapyramidal phenomena very rarely occur in children and in isolated cases in adults, they are completely reversible and disappear immediately after stopping the drug.

Mental disorders: very rarely - agitation, nervousness. Side effects such as convulsions, drowsiness and agitation are very rare and occur mainly in children and newborns.

From the immune system: very rarely - anaphylactic reactions, including anaphylactic shock, angioedema, allergic reactions, urticaria.

From the endocrine system: rarely - an increase in plasma prolactin levels due to the fact that the pituitary gland is outside the blood-brain barrier; in rare cases, this hyperprolactinemia can stimulate the appearance of neuro-endocrine phenomena such as galactorrhea, gynecomastia and amenorrhea.

From the side of the skin: very rarely - itching, rash.

CONTRAINDICATIONS

Prolactin-secreting pituitary tumor (prolactinoma);

Simultaneous administration of oral forms of ketoconazole, erythromycin or other strong inhibitors of the CYP3A4 isoenzyme, causing a prolongation of the QTc interval, such as fluconazole, voriconazole, clarithromycin, amiodarone and telithromycin;

gastrointestinal bleeding;

Mechanical obstruction or perforation, in which stimulation of the motor function of the stomach can be dangerous;

Established intolerance to the drug and its components.

FROM caution the drug should be prescribed for renal and hepatic insufficiency, as well as for children.

PREGNANCY AND LACTATION

Data on the use of the drug Motilium ® during pregnancy is not enough.

To date, there is no evidence of an increased risk of malformations in humans. However, Motilium ® should be prescribed during pregnancy only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

In women, the concentration of domperidone in breast milk is 10-50% of the corresponding plasma concentration and does not exceed 10 ng / ml. The total amount of domperidone excreted in breast milk is less than 7 mcg / day at the maximum allowable doses. It is not known whether this level has a negative effect on newborns. Therefore, if it is necessary to use the drug Motilium ® during lactation, breastfeeding should be discontinued.

SPECIAL INSTRUCTIONS

With the combined use of the drug Motilium ® with antacids or antisecretory drugs, the latter should be taken after meals, and not before meals, i.e. they should not be taken concomitantly with Motilium.

Suspension Motilium ® contains sorbitol, so it should not be taken by patients with intolerance to sorbitol.

Given the high degree of metabolism of domperidone in the liver, Motilium ® should be used with caution in liver failure.

In patients with severe renal insufficiency (serum creatinine > 6 mg / 100 ml, i.e. > 0.6 mmol / l), T 1/2 of domperidone increased from 7.4 to 20.8 hours, but the plasma concentration of the drug was lower than in healthy volunteers . Because a very small percentage of the drug is excreted by the kidneys unchanged, then adjustment of a single dose in patients with renal insufficiency is not required. However, upon re-appointment, the frequency of administration should be reduced to 1 or 2 times / day, depending on the severity of the insufficiency, and it may also be necessary to reduce the dose.

With long-term therapy, patients should be under regular supervision.

Pediatric use

Motilium ® in rare cases may cause neurological side effects. In children of the first months of life, metabolic functions and the BBB are not fully developed, and therefore they have an increased risk of unwanted neurological effects. In this regard, the dose of Motilium for newborns, infants, children over 1 year old and children of early preschool age should be calculated very accurately and strictly adhere to this dose. Neurological adverse effects can be caused in children by an overdose of the drug, but other possible causes of such effects must be taken into account.

Influence on the ability to drive vehicles and control mechanisms

Motilium ® has no or negligible effect on the ability to drive a car and work with machinery.

OVERDOSE

Symptoms: drowsiness, disorientation and extrapyramidal reactions, especially in children.

Treatment: There is no specific antidote for domperidone. In case of overdose, gastric lavage and the use of activated charcoal are recommended. It is recommended to closely monitor the patient's condition and conduct maintenance therapy. Anticholinergics, drugs used to treat parkinsonism, or antihistamines may be effective when extrapyramidal reactions occur.

DRUG INTERACTIONS

Anticholinergic drugs can neutralize the action of Motilium.

The bioavailability of Motilium when taken orally decreases after a previous intake of cimetidine or sodium bicarbonate. You should not take antacids and antisecretory drugs at the same time as Motilium, because. they reduce its bioavailability.

The main role in the metabolism of domperidone is played by the CYP3A4 isoenzyme. The results of in vitro studies and clinical experience show that the simultaneous use of drugs that significantly inhibit this isoenzyme can cause an increase in plasma concentrations of domperidone. Strong inhibitors of CYP3A4 include: azole antifungals such as fluconazole*, itraconazole, ketoconazole* and voriconazole*; macrolide antibiotics such as clarithromycin* and erythromycin*; HIV protease inhibitors, eg amprenavir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir and saquinavir; calcium antagonists such as diltiazem and verapamil; amiodarone*; aprepitant; nephazodon. (Drugs marked with an asterisk also prolong the QT c interval).

In a number of pharmacokinetic and pharmacodynamic interaction studies of domperidone with oral ketoconazole and oral erythromycin in healthy volunteers, these drugs have been shown to significantly inhibit the primary metabolism of domperidone, carried out by the CYP3A4 isoenzyme.

With the simultaneous administration of 10 mg of domperidone 4 times / day and 200 mg of ketoconazole 2 times / day, there was an increase in the QT c interval by an average of 9.8 ms during the entire observation period, at some points the changes varied from 1.2 to 17.5 ms. With the simultaneous administration of 10 mg of domperidone 4 times / day and 500 mg of erythromycin 3 times / day, there was an increase in the QT c interval by an average of 9.9 ms during the entire observation period, at some points the changes varied from 1.6 to 14.3 ms. In each of these studies, C max and AUC of domperidone were approximately 3-fold increased.

At present, it is not known what contribution to the change in the QT c interval is made by elevated plasma concentrations of domperidone.

In these studies, domperidone monotherapy (10 mg 4 times/day) resulted in prolongation of the QT c interval by 1.6 ms (ketoconazole study) and 2.5 ms (erythromycin study), while ketoconazole monotherapy (200 mg 2 times/day) and erythromycin monotherapy (500 mg 3 times / day) led to a prolongation of the QT c interval by 3.8 and 4.9 ms, respectively, during the entire observation period.

In another multiple-dose study in healthy volunteers, no significant prolongation of the QT c interval was found during inpatient domperidone monotherapy (40 mg 4 times a day, total daily dose of 160 mg, which is 2 times the recommended maximum daily dose). At the same time, plasma concentrations of domperidone were similar to those in studies of the interaction of domperidone with other drugs.

Theoretically (since the drug has a gastrokinetic effect), Motilium ® could affect the absorption of concomitantly used oral drugs, in particular drugs with a slow release of the active substance or enteric-coated drugs. However, the use of domperidone in patients receiving paracetamol or selected digoxin therapy did not affect the level of these drugs in the blood.

Motilium ® can be taken simultaneously with antipsychotics, the action of which it does not enhance; dopamine receptor agonists (bromocriptine, levodopa), whose undesirable peripheral effects, such as digestive disorders, nausea, vomiting, it suppresses without affecting their central effects.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES

The drug is dispensed by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children at a temperature of 15 ° to 30 ° C. Shelf life - 3 years.

Only after becoming a parent, a person is fully aware of the depth and reality of a beautiful phrase: children are our everything. In addition to joy, pride and hope, these words contain experiences of all colors and shades. First of all, it is a concern for the health of the child.

This feeling occupies the heart of the mother immediately after the birth of the baby. Already the first feeding may not be entirely successful. It happens that the baby spits up breast milk, behaves restlessly, cries for no apparent reason. If the situation repeats itself, there is a reason for excitement not only among the young mother, but also among specialists. But does medicine have the means to regulate the nutritional process in newborns? Yes. This is motilium.

Motilium suspension: instructions for use for children

Motilium is universal remedy to relieve symptoms of indigestion. The drug is indicated for use in adults and children. Pharmacy forms of Motilium - coated tablets, lozenges, aqueous suspension for children under five years of age.

Suspension effectively used to improve the functions of the gastrointestinal tract (GIT) in infants. The medicine optimally combines price and quality, as evidenced by the reviews of doctors and patients.

Motilium: indications for use

Regardless of the form (tablets, suspension), the drug has a general, pronounced effect on the body, due to the active substance - domperidone. Like some drugs from the category of neuroleptics, domperidone inhibits the activity of receptors that cause the gag reflex.

However, unlike psychotropic drugs, the active substance of Motilium has a low ability to penetrate and affect the central nervous system and brain regions.

The pharmacological action of Motilium is:

in increasing the motor functions of the gastrointestinal tract;
in the activation of the motor abilities of the stomach;
in the elimination of hiccups, nausea and vomiting.

The drug has the same indications for use for children and adults that present with symptoms:

vomiting, nausea, heartburn, hiccups;
heaviness in the stomach;
bloating;
frequent belching;
retention of food in the stomach (indigestion).

According to parents, the balanced taste of Motilium, do not cause disgust in children to the medicine.

Instructions for use for children of different age categories

Motilium tablets and suspensions are accompanied by an annotation, which describes in detail:

The recommended amount of the drug for a single dose. The dosage depends on the child's age and weight. The last criterion, to a greater extent, applies to children under five years of age.
frequency and time of admission.
Indications and contraindications for the use of the drug.
Possible side effects.

For children over 12 years old, Motilium is prescribed according to the "adult" scheme: two tablets (10 mg each), 3-4 times a day. Children 5 to 12 years old, half of this amount, with the same frequency. Tablets, at will and possibilities, can be replaced by a suspension, with the calculation that 1ml = 1mg.

A special "risk group" includes newborns and babies(age up to 1 year). For them, Motilium is prescribed only in the form of a suspension, only after a thorough examination and only with the consent of the attending physician. This should be discussed separately.

The complexity of diagnosing possible diseases of the gastrointestinal tract, in a newborn and infant, lies in the fact that he himself cannot convey information about well-being in a verbal way.

The baby cannot be subjected to many modern methods of research, with the help of innovative equipment. The attending physician must rely on his own experience, the results of the study of tests and external symptoms. Often, he is hindered by the excessive anxiety of the child's parents (bordering on panic), which require an immediate solution to the problem.

"False alarm"

Mothers, especially those who have acquired this status for the first time, may encounter facts for which they cannot find an explanation. In the first two days of their child's life, when feeding, they observe watery regurgitation containing dark blotches, and this worries them very much.

Usually this accumulation in the stomach of an infant is amniotic fluid with particles of coagulated blood. The manifestations are not dangerous and soon disappear.

Frequent belching of a newborn, immediately after feeding, may indicate harmless aerophony. It comes out of the ventricle, swallowed together with mother's milk.

In any case, when a mother notices something alarming in the process of feeding, she should immediately contact a specialist. The doctor will conduct an additional examination of the child, and, if necessary, prescribe gentle medication. To eliminate the problems associated with dysfunction of the housing and communal services, one of the most commonly prescribed drugs is Motilium syrup.

Dosage and daily distribution

In the first month of life, a suspension is given to newborns and infants at the rate of 2.5 ml per kilogram of weight, three times a day. For a more restful sleep of the child (and mother), Motilium can be used as an additional dose, at bedtime.

The dosage should be observed as closely as possible. The protective barrier of the baby is still too weak. The main component of the drug - domperidone, can cause a negative reaction from the / central nervous system. And although from the statistics of observations and judging by the reviews of parents, such manifestations are extremely rare, you should know the possible symptoms:

convulsive twitching of the limbs;
loss of appetite (in common parlance - the child does not take the breast);
poor restless sleep;
edema (face, limbs).

Another reaction, but already allergic nature may become skin rashes. They appear due to intolerance to the main component of the suspension, domperedone, or excipients that make up Motilium. All side effects disappear immediately after discontinuation.

Important to remember! All questions related to the use of medicines for newborns and infants, including Motilium suspensions, are the prerogative of a pediatrician.

Suspension Motilium manifests itself when exposed to the body of a child, not only as an antiemetic, but also as a prokinetic agent. It activates the peristalsis of the stomach and intestines. In case of congenital intestinal obstruction, the use of the drug can cause serious complications associated with a threat to the life of the baby.

Restrictions on the use of the drug exist for any severe lesions of the gastrointestinal tract. Motilium eliminates only the symptoms, and this is the best case. If a child is seriously ill, it is necessary, first of all, to deal with the causes of the disease and deal with them. Temporary elimination of visible symptoms, will provide time for the development of the disease.

The use of a suspension is relevant in cases where gastrointestinal dysfunction is associated with the adaptation of the newborn's body to new conditions and the accompanying reactions. Suspicion of other causes of symptoms, such as:

delayed bowel movements;
hard stomach;
flatulence;
vomiting, should be carefully checked, with the definition of an accurate diagnosis.

Motilium cannot be relied upon as a panacea. But don't give up on it for a reason. unfounded fears, which inspire contraindications and side effects of the drug indicated in the instructions.

Possibility of side effects

The instructions for Motilium tablets and suspensions list a long range of possible negative effects on the child's body. There is no need to list them here, but it is worth saying that many of them were and remain only at the level of “theoretically possible”. The drug, when used correctly, is no more dangerous than the medicine familiar to everyone since childhood - “aspirin”.

New drugs for adults, at the final stage, are being tested on volunteers. It is impossible to allow this with children, therefore, in the instructions for use, the manufacturer prefers play it safe leaving the final word to the attending physician.

Studies of the results of the practical use of Motilium and user reviews have shown that most often side effects occur when the maximum daily dose is exceeded. But all of them are of a short-term nature, and stop after the dosage is reduced or the drug is completely discontinued.

Note

It was found that the absorption of the drug depends on the acidity of the medium. In connection with this property, the instruction recommends taking the medicine 15–20 minutes before feeding babies. This applies to all age categories, and does not depend on the form of the remedy (tablets, suspension).

If the child takes antacids, then it is better to do this after meals.

The mechanism of the effect of Motilium on the fetus and infant, through the mother's body, remains not fully explored. But the price of the issue is too high in order to arrange experiments. Therefore, the use of the drug during pregnancy and lactation is not recommended.

"Motilium" for children is prescribed for frequent regurgitation, as well as to eliminate the feeling of nausea or unexpressed vomiting. The drug has proven itself well for bloating. "Motilium" refers to which also stimulate the intestinal tract. A lot of positive reviews have accumulated about the medicine, because parents experienced its action on themselves and their children. However, when using it, it is necessary to strictly follow the prescribed dosage. An excess of the drug will cause side effects.

Dosage form

"Motilium" for children is intended only in the form of a suspension. But you can also buy the drug in the form of lozenges. The solution looks homogeneous and has a white color. Produced in a bottle, which is packed in a cardboard box.

Active ingredients

With vomiting and nausea, Motilium for children can help. The suspension is based on domperidone, which blocks the corresponding receptors. As a result, the child quickly recedes an unpleasant sensation. In addition to the main component, there are also:

liquid sorbitol;
polysorbate;
microcrystalline cellulose;
sodium saccharin;
sodium hydroxide;
purified water.

The solution is placed in a dark bottle. It must also be stored in a dark place, away from direct sunlight.

How does it affect the body

It has a powerful antiemetic effect and eliminates nausea "Motilium" for children. The instruction strictly stipulates the principle of action of the active substance:

helps to quickly clear the stomach and promotes the promotion of its contents into the intestines;
the sphincter, which closes the entrance from the intestines to the stomach, works more actively;
peristalsis acts in the right direction, and not towards the esophagus;
stimulates the stomach.

Thanks to this action, the baby quickly passes pain in the abdomen, bloating and unpleasant sensations of nausea.

Direct readings

With dyspeptic symptoms associated with insufficiently fast food advancement, Motilium is prescribed for children. The instruction describes the following direct indications for taking the medicine:

Feeling of nausea.
Flatulence (increased gas formation).
Bloating.
Pain in the intestines.
Frequent belching or regurgitation in infancy.
The urge to vomit or vomiting itself.
Throwing acidic environment from the stomach back into the esophagus.

In addition to direct indications, the doctor may prescribe "Motilium" for children in the following cases:

Digestive disorders accompanied by nausea.
With dysfunction of the gastrointestinal tract.
During infectious diseases to prevent intoxication, which may occur under the influence of pathogenic bacteria.
To prevent regurgitation in newborns.
With violations in the nutrition of children, when eating causes bloating and belching.

Doctors with symptoms associated with nausea often recommend Motilium suspension for children. The reviews show that the medicine is usually well tolerated even by the smallest patients. However, the dosage should be selected by the doctor and strictly observed. Side effects are not excluded, there are also contraindications.

When the drug is prohibited

"Motilium" for children with vomiting quickly eliminates unpleasant symptoms and improves the condition. But its reception is prohibited:

in case of individual reactions to any component of the agent;
with diagnosed gastric or intestinal bleeding;
with damage to the walls of the intestine and violation of their integrity;
if there is any obstacle in the normal functioning of the digestive tract (congenital pathology, foreign body, tumor);
with some brain tumors.

Due to the impossibility of independently making a correct diagnosis, the appointment of a drug such as Motilium should be carried out by the attending physician.

Admission rules

May be recommended "Motilium" for children with vomiting. Suspension is taken 30 minutes before feeding. If you use the drug after a meal, then the absorption of the active substance decreases markedly and the effectiveness decreases. Duration of admission should not be more than 28 days. Experts warn that otherwise addiction occurs and the effect gradually decreases.

Moms note that the suspension is available in bottles that are protected from opening by children. To unscrew the cap, press it firmly down and turn it counterclockwise. For ease of dosing, a syringe is attached, on which marks are indicated, depending on the weight of the patient. However, this approach is designed for vials containing 100 ml of the product. If you buy medicine in bottles of 200 ml, then the kit already comes with a measuring cup. Therefore, for children under three years of age, a smaller package is recommended.

Children under seven years of age are prescribed a suspension. Older patients may be prescribed lozenges.

Instructions for use for children prescribe the following dosages:

Newborns - 0.25 ml per kg of body weight.
Children under 12 years old, whose weight does not exceed 35 kg - 0.5 ml per kg of body weight.
Children after 12 years and those whose weight is more than 35 kg - 10-20 ml.

Reception is allowed up to 4 times a day. In this case, the doctor can change the dosage, taking into account the diagnosis and condition of the child. However, 80 ml per day is the maximum allowed intake.

If there is a history of impaired renal function, the recommended dosage may be reduced. In this case, the child must be treated under the supervision of a physician.

Serious violations in the liver are a contraindication to the appointment of the drug. A specialist can recommend Motilium, but in an individual dosage. Adults and children over 12 years old are recommended in the form of tablets.

The total duration of admission depends on the severity of the condition, diagnosis and age of the patient. If the drug is prescribed to newborns to normalize digestion and prevent regurgitation, then the course is about three months. But the medicine is offered in small doses, calculated individually.

The occurrence of side effects

"Motilium" (syrup for children) rarely causes side effects. But if taken for too long, overdose or individual sensitivity, the following symptoms may occur:

allergic manifestations (urticaria, angioedema);
due to increased intestinal motility, pain in the abdomen;
drowsiness, lethargy, general stiffness of movements.

The drug causes a temporary increase in the body's level of the hormone prolactin. Therefore, at high doses of medication, the mammary glands in children of both sexes can swell. Older girls may have slight irregularities in their menstrual cycle.

Pharmacology

Stimulates peristalsis and eliminates nausea "Motilium". The use of children is not contraindicated due to the relative safety and low manifestation of side effects. The main active substance does not penetrate the blood-brain barrier. The pharmacological action is based only on the inhibition of the receptors responsible for vomiting. It should be noted that under the action of the drug, the secretory function of the gastrointestinal tract is not subject to serious changes.

The active component penetrates into the blood plasma and reaches its maximum value an hour after ingestion. However, the substance does not accumulate in other organs, but acts only in the gastrointestinal tract. After that, it is excreted naturally with waste products. It is known that the bulk comes out with feces (about 65%), the other part - with urine. In its original form, a small dose of the components is displayed.

It is important to know that the active substance actively affects the functioning of the brain. Therefore, drowsiness, overstrain and disturbances in attention are not excluded.

Cases of overdose

Do not exceed the dosage recommended by the instructions or your doctor. If the norm is exceeded, side effects cannot be avoided, all negative manifestations are intensified. If this happens, then you should offer the baby activated charcoal or another sorbent and plenty of water. For further correction of the condition, you should see a doctor.

Possible replacement

"Passage". The drug is considered a complete analogue, because the composition contains the same active ingredient - domperidone. However, the Russian product is produced only in the form of tablets, therefore it is recommended for children over five years old. Not suitable for younger children. The drug is recommended for lactating and pregnant women.
"Motinorm". It is also a complete analogue and can replace Motilium. However, the suspension is shown to children only from the age of one. Tablets are allowed to be taken from the age of five.
"Perinorm". In terms of its effect on the body, it is analogous. It is considered an antiemetic drug and is available in the form of a solution, tablets and ampoules for injection. The drug has a number of limitations. It should not be used by children under two years of age, during breastfeeding and in the first trimester of pregnancy.
"Domperidone". Russian tablets that are shown to adults and children over seven years old.
"Cerucal". Also not suitable for small children, because it comes in the form of tablets. But in a hospital setting, injections are used. Recommended for pregnant women (2nd and 3rd semester) and children over 2 years old.

All analogues that are produced in the form of tablets are allowed for children from five to seven years old. Newborns are shown only "Motilium".

Compatibility with other drugs

It is often indispensable "Motilium" for children with vomiting (instructions are attached to each package). The drug significantly increases the absorption of any other means. Therefore, the joint use of drugs should be discussed with your doctor.

It is known that taking together with significantly reduces the effectiveness of the active substance. Therefore, their simultaneous use is prohibited. Also, experts do not recommend simultaneously being treated with Motilium and antibiotics.