Regidron - Indications for Use. Regidron powder: what helps
It is well known that the human body consists of almost 70–80% water. In fact, this generally accepted expression is not entirely true. Liquid medium filling human body, is a kind of saline solutions, consisting of various chemical compounds. Therefore, excessive loss of moisture leads to dehydration and loss of dissolved fluids. useful substances necessary to maintain normal life human body.
For this reason, diseases accompanied by severe vomiting and long-term diarrhea. Such ailments include infectious lesions (dysentery, cholera), inflammation of the large (enterocolitis) and small intestines (enteritis), diseases of the gallbladder and pancreas, toxicosis in pregnant women. As a rule, such diseases lead to significant loss of fluid - dehydration.
An aqueous solution of Regidron powder not only replenishes fluid loss by the body, it effectively corrects acid-base balance, therefore it is recommended as an additional treatment for complex treatment diarrhea caused infectious lesion, for example, with cholera.
Also, to prevent acid-base imbalance (acidosis), Regidron is prescribed to people with increased sweating, hot shop workers, as well as during intense physical activity. Everyone knows how much fluid an athlete loses during training sessions.
The main advantage of Regidron powder is its low sodium chloride content, which protects a person from oversaturating the body with salt. But sufficient quantity potassium chloride promotes the rapid restoration of this microelement in the blood. This is extremely important for normal functioning heart muscle.
Of course, in any case, treatment is prescribed by a doctor. Preparation of the drug is not difficult. To do this, you need to add a liter to the contents of the bag. boiled water and cool remedy. Then, after shaking the liquid, take small sips after each attack of diarrhea. To obtain the desired effect, it is recommended to drink approximately 10 ml/kg of body weight within an hour. When dehydration decreases, the dose of the drug taken is reduced to 5 ml/kg body weight. Availability severe vomiting also contributes to excessive fluid loss, so after each vomiting attack you need to take an additional 10 ml/kg of solution.
As a rule, the course of using Regidron lasts no more than 3 to 4 days. If diarrhea ends earlier, treatment is stopped. During treatment, you should avoid eating foods that are rich in simple carbohydrates and fats.
The drug Regidron should not be considered absolutely safe. Indications for the use of this powder indicate that its overdose threatens muscle and nervous overstrain, loss of strength, clouding of consciousness, even stopping breathing. A slight excess of the suggested dosage makes sense only if confirmed additional administration solution based on special laboratory tests.
The drug Regidron has contraindications, which include diseases such as intestinal obstruction, impaired renal function, type 1 and 2, excessive sensitivity to certain ingredients included in this drug. In addition, before taking this drug, additional medical consultation is required if the syndrome is present. chronic fatigue, slow speech, high temperature body, anuria, diarrhea mixed with blood and lasting more than 5 days.
It should be noted that drug interactions Regidron with other medications has not been fully studied. Therefore, a preliminary consultation with a doctor is required. Such a warning is quite reasonable, although the drug is sold without a prescription in the pharmacy network. Do not self-medicate. Take care of yourself!
Regidron is a fairly well-known pharmaceutical brand from the Finnish company Orion Corporation. This drug is designed to replenish fluid deficiency in the body and rid it of toxins. Available in powder form for the preparation of a solution for oral administration. This powder dissolves well in water to form a clear solution with a salty-sweet taste. Rehydron contains four substances: sodium chloride and citrate, potassium chloride and dextrose (the sweetness of the rehydron solution is due precisely to the presence of the latter).
Restoring the balance of fluid and electrolytes and achieving a stable level of fluid volume is a key therapeutic “background” for many diseases, against the background of which the recovery process proceeds much faster. These goals can be achieved in two ways: either by intravenous administration of isotonic electrolyte solutions, or by enteral administration of the same solutions. For the first time, the idea of compensation of fluid and electrolytes in patients arose in 1830 among domestic doctors from the Moscow Institute of Artificial mineral waters: This is how they treated cholera. However, it subsequently took about 120 more years for the principle of rehydration to gain acceptance. wide use in the treatment of debilitating diarrhea caused by cholera. At the same time, along with the intravenous administration of replacement solutions, their oral administration also began to be practiced. The use of enteral solutions was based on the ability of glucose (dextrose) to increase absorption into small intestine sodium, and even against the background of secretory losses caused by the action of bacterial toxins. Regidron embodies a group of enteral drugs that correct water-electrolyte balance, shifted due to dehydration of the body. Compared to recommended World Organization healthcare standard oral rehydration solutions, Rehydron has a slightly lower osmolality (content of osmotically active particles): solutions with reduced osmolality have been proven to be very effective in restoring target fluid and electrolyte levels in the body.
The sodium concentration in rehydron is also lower than traditionally used in similar drugs(the purpose of which is to reduce the risk of developing hypernatremia), and potassium, on the contrary, is higher: thereby it is possible to restore its level more quickly.
To prepare a rehydron solution you will need 1 liter of boiled and cooled water. You only need a liter of water, because... a smaller amount will increase the concentration of the solution, which can provoke hypernatremia. Ready solution must be used within 24 hours, during which time it must be stored at a temperature of 2° to 8°C, i.e. in a refrigerator. The solution must be pristine: adding any other components may interfere with the effect of the drug. Before treatment, it is necessary to assess the overall weight loss and the degree of dehydration. To avoid severe dehydration, it is recommended to start taking the drug at the first signs of diarrhea. As a rule, rehydron is used for 3-4 days. The end of treatment indicator is the cessation of diarrhea. The tactics for taking rehydron for the purpose of rehydration are as follows: for the first 6-10 hours, you should take the solution in quantities twice as high as the weight loss caused by diarrhea (i.e., if the patient has lost 400 g, you should take 0.8 liters of rehydron); no other liquid is required during this period. If diarrhea does not stop, then further administration of the drug is carried out according to a special scheme given in the instructions for use. Severe dehydration is corrected by intravenous administration rehydration agents, after which the patient can be transferred to rehydration.
Pharmacology
A drug for correcting energy and electrolyte balance.
Restores water-electrolyte balance disturbed by dehydration of the body; corrects acidosis.
The osmolality of the Regidron solution is 260 mOsm/l, pH - 8.2.
Compared with standard oral rehydration solutions recommended by WHO, the osmolality of Regidron is slightly lower (the effectiveness of rehydration solutions with reduced osmolality is well proven), the sodium concentration is also lower (to prevent the development of hypernatremia), and the potassium content is higher (for more quick recovery potassium level).
Pharmacokinetics
There are no data on the pharmacokinetics of the drug Regidron.Release form
Powder for solution for oral administration white, crystalline, soluble in water; the prepared solution is transparent, colorless, odorless, with a salty-sweet taste.
Laminated aluminum foil bags (4) - cardboard packs.
Laminated aluminum foil bags (20) - cardboard packs.
Dosage
One sachet is dissolved in 1 liter of water, the prepared solution is taken orally. If you are not sure that the water is suitable for drinking, it must be boiled and cooled before preparing the solution. The prepared solution should be stored in a cool place at a temperature of 2° to 8°C and used within 24 hours. No other components should be added to the solution so as not to disrupt the effect of the drug.
Before starting treatment, the patient should be weighed to assess weight loss and degree of dehydration.
Patient's food or breast-feeding should not be interrupted during oral rehydration therapy or should be continued immediately after rehydration. It is recommended to avoid foods rich in fats and simple carbohydrates.
To prevent dehydration, Regidron should be taken as soon as diarrhea begins. Usually the drug is used for no more than 3-4 days, treatment is stopped with the end of diarrhea.
In case of nausea or vomiting, it is advisable to give the solution chilled in small repeated doses. A nasogastric tube may also be used under medical supervision.
For rehydration, Regidron is taken during the first 6-10 hours in an amount that is twice the loss of body weight caused by diarrhea. For example, if the body weight loss is 400 g, the amount of Regidron is 800 g or 8.0 dl. During this phase of treatment, the use of other fluids is not required.
If diarrhea continues after correction of dehydration, it is recommended to administer Regidron, water and other liquids within 24 hours according to the following scheme:
| Body weight (kg) | Total amount of fluid required (dl) | Regidron (dl) | Water (dl) | Other liquids (dl) |
| 5 | 8.3 | 3.5 | 2.1 | 2.7 |
| 6 | 10.0 | 4.2 | 2.5 | 3.3 |
| 7 | 10.5 | 4.4 | 2.6 | 3.5 |
| 8 | 11.0 | 4.6 | 2.8 | 3.6 |
| 9 | 11.5 | 4.8 | 2.9 | 3.8 |
| 10 | 12.0 | 5.0 | 3.0 | 4.0 |
| 12 | 13.0 | 5.4 | 3.2 | 4.4 |
| 14 | 14.0 | 5.8 | 3.5 | 4.7 |
| 16 | 15.0 | 6.2 | 3.7 | 5.1 |
| 18 | 16.0 | 6.6 | 4.0 | 5.4 |
| 20 | 17.0 | 7.0 | 4.2 | 5.8 |
| 25 | 18.0 | 7.5 | 4.5 | 6.0 |
| 30 | 19.0 | 8.0 | 4.8 | 6.2 |
| 40 | 21.0 | 9.0 | 5.4 | 6.6 |
| 50 | 23.0 | 10.0 | 6.0 | 7.0 |
| 70 | 27.0 | 12.0 | 7.2 | 7.8 |
Overdose
Symptoms: when administering Regidron solution in a large volume or excessive concentration hypernatremia is possible (weakness, neuromuscular agitation, drowsiness, confusion, coma, sometimes even respiratory arrest); in patients with impaired renal function, metabolic alkalosis may develop, which manifests itself in decreased ventilation, neuromuscular excitation and tetanic convulsions.
Treatment: in case of significant overdose, medical supervision is required. Correction of electrolyte and fluid balance should be based on laboratory data.
Interaction
Drug interactions with Regidron have not been studied.
The drug solution has a slightly alkaline reaction, and therefore can affect the effectiveness of medications, the absorption of which depends on the pH of the intestinal contents.
Diarrhea itself can alter the absorption of many drugs that are absorbed in the small or large intestine, or drugs that are metabolized through the intrahepatic circulation.
Side effects
Indications
- restoration of water-electrolyte balance, correction of acidosis during acute diarrhea(including cholera), with heat injuries associated with disturbances of water and electrolyte metabolism; for the purpose of prevention - thermal and physical exercise leading to intense sweating;
- oral rehydration therapy for acute diarrhea with mild (3-5% weight loss) or moderate (6-10% weight loss) dehydration.
Contraindications
- renal dysfunction;
- insulin dependent diabetes;
- non-insulin-dependent diabetes mellitus;
- unconscious state;
- intestinal obstruction;
- hypersensitivity to the components of the drug.
Features of application
Use during pregnancy and breastfeeding
In recommended doses, Regidron can be prescribed during pregnancy and lactation.Use for renal impairment
The drug is contraindicated in case of impaired renal function.special instructions
Severe dehydration (weight loss >10%, anuria) should be corrected with the use of rehydration agents for intravenous administration, after which Regidron can be prescribed.
A packet of Regidron is dissolved in 1 liter of water. If too concentrated a solution is given in the recommended volume, the patient may develop hypernatremia.
Sugar should not be added to the solution. Food can be given immediately after rehydration. If you vomit, wait 10 minutes and let the solution be drunk slowly, in small sips. Patients who have developed dehydration due to renal failure, diabetes mellitus or other chronic diseases, in which the acid-base, electrolyte or carbohydrate balance is disturbed, careful monitoring is required during therapy with Regidron.
When using the drug Regidron, a doctor's consultation is required. following cases: slow speech, rapid fatigue, drowsiness, the patient does not answer questions, an increase in body temperature of more than 39 ° C, cessation of urine output, the appearance of loose bloody stools, diarrhea lasting more than 5 days, sudden cessation of diarrhea and the appearance of severe pain if treated at home ineffective and impossible.
Impact on the ability to drive vehicles and operate machinery
Regidron does not affect the ability to drive vehicles or operate machinery.
Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.
Regidron: instructions for use
Compound
active substance: 1 sachet contains 2.5 g of potassium chloride, 3.5 g of sodium chloride, 2.9 g of sodium citrate, 10 g of anhydrous glucose;
pharmachologic effect
Pharmacotherapeutic group. Electrolyte preparations with carbohydrates. Salt formulations for oral rehydration. Pharmacological properties. Regidron solution is used to correct the loss of electrolytes and fluid due to diarrhea and vomiting. Glucose promotes the absorption of salts and citrates, which helps balance the acid-base balance of the blood. The osmolarity of the Regidron solution is 260 mOsm/l, the pH is slightly alkaline - 8.2.
Compared to standard oral rehydration solutions recommended by WHO, Regidron's osmolarity is slightly lower (the effectiveness of rehydration solutions with reduced osmolarity is well proven), the sodium concentration is slightly lower (to prevent the development of hypernatremia), and the potassium content is higher (to restore potassium levels more quickly ).
Pharmacokinetics
The pharmacokinetics of water, electrolytes and glucose included in Regidron correspond to the natural pharmacokinetics of these substances in the body.
Indications for use
Restoration of water-electrolyte balance, correction of acidosis in acute diarrhea (including cholera), diarrhea with mild (weight loss of 3-5%) or moderate (weight loss of 6-10%) degree of dehydration, with heat injuries associated with fluid disturbances electrolyte metabolism. For preventive purposes: thermal and physical stress leading to intense sweating.
Contraindications
Hyperkalemia, renal failure, diabetes mellitus, severe forms hypertension. Interaction medicines. During treatment with Regidron, you should not take medications whose absorption depends on the pH of the intestinal contents.
The drug solution has a slightly alkaline reaction, so it can affect medications, the absorption of which depends on the pH of the intestinal contents.
Directions for use and doses
The drug Regidron, dosed powder, is intended for the preparation of a solution for oral use.
The powder of 1 sachet is dissolved in 1 liter of boiled water. The finished solution is cooled to room temperature and stirred again before use.
The prepared solution should be taken after each loose stool, in small sips at the dose recommended by the doctor. For 4-10 hours, 50-100 ml/kg body weight. After the first stage of rehydration, Regidron solution should be given 10 ml/kg body weight after each loose stool. In children over 3 years of age and adults, in the first 4-6 hours, the dose of Regidron solution can be 500-1000 ml, then 200 ml after each loose stool. If diarrhea is accompanied by vomiting, then it is necessary to let the patient drink Regidron solution again after 10 minutes. after vomiting.
Side effect
If any unusual reactions occur, be sure to consult your doctor regarding further use of the drug!
Overdose
When inserted too large quantity or when administering an overly concentrated solution of Regidron, hypernatremia and hyperkalemia may occur. Metabolic alkalosis may occur in patients with reduced renal function. Symptoms of hypernatremia include weakness, neuromuscular agitation, drowsiness, confusion, coma, and sometimes even respiratory arrest. Metabolic alkalosis may manifest as decreased ventilation, neuromuscular excitation, and tetanic seizures.
In case of severe overdose with pronounced consequences, the administration of Regidron should be discontinued. We need to see a doctor. Correction of electrolyte and fluid balance should be carried out by a physician based on laboratory data.
Features of application
Severe dehydration (weight loss >10%, anuria) should be treated first with intravenous drugs for rehydration. After this, Regidron can be used to treat diarrhea.
A sachet of Regidron should be dissolved in 1 liter of water. If the dose is exceeded, the patient may develop hypernatremia. Patients in whom dehydration has developed due to renal failure, diabetes or other chronic diseases that disrupt the acid-base, electrolyte or carbohydrate balance require careful monitoring during therapy with Regidron, including hospitalization.
If during the use of the drug Regidron there are following situations, you need to see a doctor:
The patient develops slow speech, quickly becomes exhausted, becomes drowsy, and does not answer questions;
The temperature rises above 39°C;
Urine production stops;
Liquid, bloody stool appears;
Diarrhea lasts more than 5 days;
Diarrhea suddenly stops and severe pain;
If treatment at home is unsuccessful or impossible.
The patient's nutrition or breastfeeding should not be interrupted during oral rehydration therapy or should be continued immediately after rehydration. It is recommended to avoid foods rich in fats and simple carbohydrates. To prevent dehydration, use of the drug Regidron should be started as soon as diarrhea begins. Usually the drug should be used for no more than three to four days, treatment stops with the end of diarrhea.
Regidron refers to drugs that restore acid-base and water-electrolyte balance in the patient's body. Regidron actively promotes the correction of acidosis, neutralizes negative consequences caused by severe dehydration body. Restores optimal balance of fluid and electrolytes. Medicine recommended for use against diarrhea, as well as heat or sunstroke with accompanying increased sweating. Available in the form of a powder intended for the preparation of solutions taken orally.1. Pharmacological action
Regidron is used for diarrhea and vomiting, which results in the development of a disorder acid-base balance, due to the loss of electrolytes along with water. The composition of the drug includes, which promotes the absorption of salts and citrates, which restore the acid-base balance.2. indications for use
- Maintaining and restoring acid-base balance;
- Rehydron is used for diarrhea of infectious origin;
- Regidron is taken to prevent disturbances in blood pH levels;
- It can be used to maintain acid-base balance during intense sweating due to physical or thermal stress.
3. Method of application
The contents of 1 sachet of Regidron are dissolved in 1 liter of boiled water and the solution is allowed to cool. It must be taken in small sips, stirring thoroughly before doing so, after each loose stool. You need to take 10 ml/kg body weight per hour; after eliminating dehydration, the dose can be reduced to 5-10 ml/kg body weight.For vomiting, use an additional 10 ml/kg body weight after each attack of vomiting.
4. Side effects
Subject to the rules of use and dosage of Regidron, side effects don't appear.5. Contraindications
6. During pregnancy and lactation
Can be used during pregnancy, since Regidron does not have negative impact for the fruit7. Interaction with other drugs
It is necessary to monitor the combination with drugs that require certain pH values for absorption, since Regidron has an alkaline reaction.8. Overdose
Hypernatremia and hyperkalemia may occur. Symptoms include arrhythmia, impaired consciousness, drowsiness, and rarely respiratory arrest. In case of violation glomerular filtration metabolic alkalosis may develop. In case of an overdose of Regidron, the electrolyte balance is corrected.9. Release form
Powder 18.9 g. 4 or 20 pcs.10. Storage conditions
The prepared Regidron solution is stored in the refrigerator for no more than 2 days, at a temperature of 2-8 degrees.11. Composition
1 packet of powder:
- sodium chloride - 3.5 g;
- sodium citrate - 2.9 g;
- potassium chloride - 2.5 g;
- dextrose - 10 g.
12. Conditions for dispensing from pharmacies
The drug is available without a prescription.Found a mistake? Select it and press Ctrl + Enter
* Instructions for medical use for the drug Regidron has been published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST
