Pimafucin ointment clotrimazole which is better. Clotrimazole or pimafucin: which is better and what is the difference (difference in compositions, doctors' reviews)

In the people, this disease is called thrush. The disease is recognizable by its symptoms. Men feel discomfort in the region of the genital head. The patient may feel a burning sensation, cheesy unpleasant discharge appears. There is an effective ointment for thrush in men on sale, and not one.

Men have no less than women the risk of contracting and getting sick with candidiasis. If left untreated, the disease progresses, it can develop into urethritis or candidal prostatitis. A man, as soon as he notices the first symptoms of the disease, should go to the urologist, take tests, and if the diagnosis is confirmed, the doctor will prescribe treatment for him.

What reasons provoke what? What kind of ointment to use for the treatment to be effective? Consider in the article.

It's a fungus. It is transmitted during sexual intercourse without the use of contraception, it occurs for other reasons. Ointment, among other means, effectively kills the fungus.

Interesting! Thrush is not a sexually transmitted disease.

Its symptoms are similar to many unpleasant diseases. If you get sick, immediate treatment is required. Choose the right drug. For example, the ointment removes it perfectly in the shortest possible time.

Most often, thrush at the initial stage is located on the head of the penis. In addition, it extends to the foreskin. This disease does not give any special complications and the ointment heals it quickly.

If the stage is chronic, then only your doctor should select the ointment against thrush in men. Consult with your urologist. Most often, the doctor will prescribe an ointment and more than one. They are easy to use and powerful.

Signs of the disease

Depending on the stage of the disease and the immunity of the man, the following symptoms may be observed:

When urination occurs, he feels itching with burning and pain.

The erection will be increased, but during the sexual intercourse the man will feel the same pain with burning and itching.

The foreskin and head of the penis will have swelling.

Partners will smell the milk that has turned sour.

Under the foreskin itself or on the head of the organ there will be a curdled discharge that has a white with a gray tint. When you try to remove the discharge, erosion or wounds are possible in that place. The sores may even bleed. Requires treatment.

Doctor says:“Thrush is transmitted to a man from a woman and it is important for both to monitor their health and treat the disease in time.”

Causes of the disease

Sexual intercourse without protective equipment is just one of the causes of infection and why thrush occurs. Either way, treatment is required.

Interesting! If a man has strong immunity and he is not sick with other sexually transmitted infections, there are no various diseases of the internal organs in a chronic form, thrush is cured by self-purification.

If you have symptoms of this disease, immediately go to an appointment with a urologist. He will examine you, ask questions and make a correct diagnosis. Prescribe effective treatment.

Thrush is transmitted not only as a fungus from partner to partner, there are other causes of occurrence:

Problems in the endocrine system;

Diabetes;

You are overweight and your groin sweats more, which is a good breeding ground for the fungus;

Metabolism is disturbed;

Hypovitaminosis;

Diseases of the digestive tract;

With stress, nervous overload, a mild degree of the disease develops;

If after drinking alcohol you feel a burning sensation in the groin area, then you have thrush in the initial stage and treatment is necessary.

Do not rush to blame your partner for the infection. The cause of the disease will be determined by the doctor after a complete examination.

Ointments for thrush for men

The structure of the male genital organs is such that the thrush will not hide anywhere, it will be on the surface and is not as often manifested as in women. It's easier to treat. Every third infected candidiasis develops "secretly" this disease and insidiously. Requires prompt and prompt treatment.

In chronic form, thrush often provokes inflammation of the appendages. A man should know that at the time when the symptoms appear, the infection will have long been in the body.

Symptoms that should alert you are pain when urinating, when there is a burning sensation on the head and in the foreskin and swelling is observed. It happens that the head is covered, as it were, with a white film, and under it, there may be a rash. Urgent treatment is needed.

The ointment has both advantages and disadvantages. She quickly destroys the thrush. The ointment is convenient to apply to the organ. It is indeed a very effective drug.

Important! Ointment from thrush acts very quickly and the man feels relieved. The symptoms are not so obvious. Treatment, thanks to this tool, will go faster.

This is a local therapy and the risk of any complications is very low. Ointment for men from candidiasis is not expensive. This is an excellent drug, competitive with other anti-fungal agents.

Unfortunately, ointments most often contain only a few ingredients and the fungus cannot be completely cured in one application to the organ. Treat systematically. A man should lubricate the affected areas constantly for some time, as described in the instructions.

The best ointments

The fungus is treated with various antimycotic drugs.

These are ointments with creams, and a remedy that is sold in the form of a solution. Treatment, when a specific remedy is used, will be prescribed by the doctor.

The most effective drug "Pimafucin" with "Clotrimazole" and with "Triderm" is different. The man who uses them will soon be healthy.

If you have a chronic form of candidiasis and you have used all these remedies and there is no desired effect, pay attention to the ointment for the treatment of thrush in men: Flucostat with Diflucan and other potent drugs.

Advice. Man, use the drug that your doctor prescribes for you.

clotrimazole

Imidazole is part of this drug. Even a small amount of "Clotrimazole" can slow down the development of fungi and kill the infection. Ointment from thrush will accumulate on the mucosa, in the place where you use it, and due to the high concentration, the fungus will be more likely to be destroyed. What an effective remedy!

A man should apply the cream 2 or 3 times a day to the foreskin. Use the product regularly for a week and there should be a complete recovery from the fungus.

Advice. Concerning the scheme of use and a dose, consult with the doctor. When using a medicine prescribed by a doctor, there should be no side effects.

Nystatin ointment

Excellent ointment for candidiasis. It treats thrush well, including those that have arisen due to prolonged use of antibiotics.

Every day and 2 times apply the product to the affected area. Let the ointment be on the affected area with a thin layer. The course of treatment will be prescribed by your doctor. It can take from 2-3 days to 3 or 4 weeks.

If you have any allergies while using this drug, see your doctor. Let this ointment be canceled and another one appointed.

Ecodax

The drug "Ecodax" is produced in the form of a cream. The agent must be rubbed into the affected area of the mucous membrane and skin.

In composition, it is close to imidazole and is used similarly. The product is applied topically and the effect is visible after 3 days of use.

If the ointment causes an allergy with some of its components, it should not be used.

Pimafucin

This is an excellent ointment for men with thrush. It contains an antibiotic.

It acts as an antifungal agent. Natamycin is the main component.

Ointment perfectly kills candidal fungi. "Pimafucin" use 1 or 2 times a day.

Apply the drug externally. The course of treatment will be prescribed by a doctor. Most often it happens 3-7 days.

Doctor says:“When no traces of the fungus are visible on the genitals, continue applying the drug for another 2-3 days.”

It is important that all symptoms disappear and the discomfort goes away. To do this, follow the advice of your doctor. Follow the scheme, follow the recommendations and be healthy.

Now you know that not everyone who has contracted the fungus from a partner gets sick, but only every third. This is due to the fact that those who have stronger immunity themselves are cleared of candidiasis. They don't need any medication.

When a person suffers from some other sexual infection or has various diseases of the internal organs, his immunity is weakened and he, becoming infected, falls ill with this fungus. If you are sick, immediately use the ointment prescribed by the doctor for thrush for men.

Take good care of your health.
When you have close contact with a new partner, be sure to protect yourself with a condom. This will significantly reduce the risk of infection with thrush.
Lead a healthy lifestyle.
Eat lots of salads and fresh fruits.
If you smoke, try to quit.
Do not drink often alcohol and even low-alcohol drinks.

Nobody cares about your health better than you!

Or thrush are creams and ointments that allow you to get rid of the disease in a short time. The use of a particular ointment is prescribed by a doctor, depending on the clinical picture of each specific case of the disease. Ointment is a common drug, it is absorbed into the blood in different ways and can have a therapeutic effect on the body as a whole. Pregnant women should use ointments and creams for thrush only after medical consultation. The most commonly prescribed ointments for thrush are clotrimazole and pimafucin.

Clotrimazole for thrush

Clotrimazole is a powerful antifungal agent. When it enters the human body, it finds the source of the disease, that is, Candida, and destroys its cell membranes. The fungus itself becomes unviable. The use of the ointment in small quantities will block the spread of cells along the vaginal mucosa, a large dose of the drug leads to their complete destruction. Clotrimazole ointment is applied at least twice a day. It must be carefully rubbed into the damaged areas of the mucous membrane. After applying the product, it is recommended to lie down for 15-20 minutes until it is completely absorbed. Sexual intercourse during treatment is not contraindicated, but it is best to refrain from them. In addition, the sexual partner should also undergo treatment, since thrush is sexually transmitted.

Clotrimazole ointment is contraindicated in the first trimester of pregnancy, as well as when breastfeeding a child. In rare cases of using the drug, side effects appear in the form of burning, itching and redness at the sites of its local application. An overdose of the drug is not possible due to its topical application. There are no contraindications for use. Clotrimazole ointment can be used with other drugs, but it helps reduce the effect of some antibiotics, including nystatin. If within a month of using the drug there are no positive trends in the treatment of thrush, you should seek the help of a specialist.

In most cases, clotrimazole is able to eliminate the main symptoms of thrush, however, for the complete destruction of the fungus, complex treatment with tablets and ointments should most often be used. If the thrush has not been completely cured, she will declare herself again in the near future. Often, when treating thrush with ointment, an improvement in the condition is observed already in the first days of its use, but this is not a reason to abandon the treatment. Be sure to complete the course prescribed by the doctor.

Pimafucin from thrush

The main active ingredient of pimafucin is a special substance - natamycin, potato starch, calcium carbonate, talc, titanium oxide, sucrase, etc. act as auxiliary components. Pimafucin is an antifungal macrolide antibiotic that has a fungicidal effect. Natamycin has a destructive effect on the membrane cells of microorganisms, thereby completely destroying them. The period of drug treatment is determined depending on each specific case of the disease. After the disappearance of the main signs of thrush, it is recommended to apply the cream for a few more days.

A large number of women, including pregnant women, with various diagnoses of diseases caused by fungi, including thrush, took part in the clinical trials of pimafucin. A positive result occurred already in the first days of using the drug in 95% of patients. The results of the studies also proved the high efficacy of the drug in the treatment of recurrent candidiasis. Already after 3 days of using the ointment in pregnant patients, the main signs of thrush disappeared, the well-being and condition of the fetus improved, in some cases the symptoms of a threatened miscarriage were eliminated. A further microbiological study of vaginal discharge showed a complete absence of fungal cells and its spores. The result was unsatisfactory in women who repeatedly had thrush and underwent a second course of drug treatment, which could provoke the development of resistance of this infection to treatment with traditional antifungal drugs.

Pimafucin cream is applied topically, gently rubbing into the affected areas of the skin and mucous membrane, at least 2 times a day. Prolonged use of the cream does not adversely affect the vaginal mucosa. After applying the cream, it is recommended to lie down for a few minutes. The course of treatment lasts at least 7-9 days. At the same time, it is recommended to treat thrush in a sexual partner, even in the absence of its main signs.

Pimafucin is one of the few drugs that are not contraindicated during pregnancy. The main active ingredient of the drug is practically not absorbed from the gastrointestinal tract and mucous membranes, which means it does not enter the bloodstream and cannot affect the development of the fetus. Pimafucin cream is completely non-toxic and can be used even in late pregnancy and just before childbirth. The use of this drug can prevent the transmission of the disease from mother to child during its passage through the birth canal.

Side effects of the drug are very rare. Among them: diarrhea, nausea, burning and tingling in the area of application. The main contraindication to the use of pimafucin cream may be hypersensitivity to its main components. The drug is often used to treat thrush in newborns.

Pimafucin can be used not only to treat vaginal candidiasis, but also candidiasis of the skin and nails, ringworm, external. To date, an overdose of the drug has not been observed. Pimafucin is dispensed from pharmacies without a doctor's prescription.

It should be remembered that creams and ointments are medicines, and therefore it is recommended to consult a specialist before using them. During pregnancy, this is the main condition for their use.

Candles for thrush is the most convenient way to locally treat vaginal candidiasis in women. The action of vaginal suppositories is due to the deep penetration of the active antifungal substance into the mucous membrane, while the pathogen is destroyed, inflammation is eliminated, and the inflammation is reduced.

The pharmaceutical industry offers a wide range of different ones - these are both suppositories for local treatment and drugs for oral administration, which are prescribed by a doctor in severe forms of candidiasis, in the chronic course of thrush as part of complex therapy.

What candles from thrush are better? There is one answer to this question - these are the drugs to which the Candida fungus is sensitive according to the result of bacterial seeding and determining the resistance, resistance or sensitivity of the pathogen to a particular drug. Since in chronic, often relapsing, it may not be effective due to the development of drug resistance in fungal agents.

Uncontrolled, self-treatment of thrush leads both to the development of chronic candidiasis and to a violation of the vaginal microflora. Moreover, many women actively practice, which is not acceptable, as it only provokes further progression of the disease, further disrupting the vaginal microflora. Only the attending physician, based on the patient's history, clinical picture, taking into account the sensitivity of the pathogen, prescribes an adequate treatment regimen. Even with the disappearance of symptoms, clinical recovery is considered to be the absence of fungi according to laboratory data for the next 3 months.

Rules for the use of suppositories against thrush

In the absence of therapy from a permanent partner, a ping-pong effect occurs when a woman, after treatment, is again subjected to a fungal attack during unprotected intercourse.

During therapy, you should either refuse sexual intercourse or use condoms. Candles are inserted deep into the vagina at night to improve the absorption of the drug.

When a woman is diagnosed with vaginal candidiasis, she should be analyzed together with her doctor, because without eliminating or minimizing provoking factors, thrush can occur again and again.

Very often, candidiasis indicates the presence of other sexually transmitted infections (mycoplasmosis, gonorrhea, trichomoniasis, etc.) as well as the development of gardnerellosis ().

Depending on the intensity of the symptoms, acute or chronic process, the treatment may differ in the course of therapy, in some cases it is enough to use 1 suppository, and in the chronic course of the process this is not enough and longer treatment is required.

Vaginal suppositories cannot be used during menstruation, with the exception of Povidone-Iodine (Iodoxide, Betadine) and Sertaconazole (Zalain).
For 1 candle, you can use the following suppositories - Zalain, Lomexin
3 candles each - Livarol, Gino-pevaril, Pimafucin.
5-14 suppositories each - Macmirror, Clotrimazole, Ginezol, Yodoxide, Nystatin, Polygynax, Terzhinan, Irunin.

During treatment, you should not wear synthetic, tight underwear, you must follow all the rules of intimate hygiene, change towels and linen daily, do not use chemicalized, flavored pads, toilet paper, intimate hygiene liquids, which only worsen the condition.

The best candles for thrush - Livarol, Pimafucin, Zalain, Nystatin, Clotrimazole, Lomixin, Macmirror - the pros and cons of using

Sertaconazole - Zalain

Zalain(price 1 soup. 480-520 rubles, prices 2018)

It is a derivative of benzothiophene and imidazole.

Use in pregnancy: There is no sufficient data on the potential harm to the fetus and during the feeding period. But given the single method of application and the lack of systemic action of Zalain - during pregnancy, lactation, it is possible to use it in a situation where the intended benefit to the woman is higher than the possible risk to the child.
Contraindications: Hypersensitivity
Side effects: that do not require discontinuation of the drug, allergic reactions.
Mode of application: 1 suppository from thrush is inserted into the vagina at night once, if symptoms persist after a week, re-use is possible. Before use, wash the external genitalia with neutral soap. May be used during menstruation.
Advantages and disadvantages: The advantage of using Zalain from thrush is the one-time administration of the drug, high efficiency, the ability to use during menstruation, the disadvantage is the high price.

Ketoconazole - Livarol

Livarol (price 430 rubles for 5 pcs. 600-800 for 10 pcs.)
Ketoconazole 230-400 rubles.

Contraindications: hypersensitivity, 1st trimester of pregnancy, in the 2nd-3rd trimester with caution.
Side effects: irritation, redness of the vaginal mucosa, itching. Skin rash, urticaria.
Application: In the supine position, it is injected into the vagina deeply, 1 suppository for 3-5 days, with the chronic nature of thrush for 10 days.
Pros and cons: The advantage is the rapid effect, almost no allergic reactions. It is prescribed most often at the first time the diagnosis is established, with frequent or prolonged use, drug resistance occurs in the pathogen.

Itraconazole - Irunin

Irunin - vaginal tablets 10 pcs. 300-320 rub.

Contraindications: 1st trimester of pregnancy, in the 2nd-3rd trimester with caution, hypersensitivity, lactation
Side effects: itching, burning, skin rash that does not require discontinuation of the drug.
Application: at night for 7-14 days.
Pros and cons: An effective remedy for recurrent thrush and resistance to other antifungal agents, the disadvantage is that it cannot be used in the 1st trimester.

Nystatin + Nifuratel

(price 680 rubles for 8 pcs.)

Pregnancy: approved for use
Contraindications: hypersensitivity
Side effects: very rarely itching, skin rash
Application: Intravaginally, 1 suppository 8 days before bedtime.
Advantages and disadvantages: The main advantage in the possibility of therapy during pregnancy, the disadvantage is the high price.

(30-60 rubles 6 pcs),
Candide B6 (70 r), Antifungol, Kanesten,
Candizol, Yenamazol 100, Candibene.

Contraindications: hypersensitivity, it is strictly forbidden to use in the 1st trimester of pregnancy, while breastfeeding
Side effects: burning, itching, vaginal discharge, abdominal pain, headache, cystitis, frequent urination, pain during intercourse.
Mode of application: within 6 days, 1 suppository deep into the vagina at night.
Advantages and disadvantages: The advantage is that these are inexpensive suppositories against thrush, the disadvantage is frequent side effects, the rapid development of resistance in fungal agents.

Miconazole — Klion D, Neo-Penotran

Ginezol 7 (280-300 rubles), Gino-dactanol, Daktarin, Mikozon (cream).
Combined preparations, which include, in addition to miconazole, also metronidazole.

Klion-D 100 (price 330 rubles ..),
Neo-Penotran (14 pieces 700 rubles),
Metromicon-Neo (14 pieces 300-350 rubles)

Contraindications: hypersensitivity, with caution in pregnancy 2-3 trimester, lactation (suspend feeding during treatment) in diabetes mellitus, liver dysfunction, herpes
Side effects: only at the beginning of treatment, a feeling of discomfort, burning, itching, nausea, diarrhea, abdominal pain is possible.
Mode of application: within 6-7 days at night, 1 suppository., you can not take alcohol during treatment.
Pros and cons: quick effect, wide spectrum of activity, does not cause dysbacteriosis, effective for frequent recurrences of thrush, the disadvantage is the danger of using during childbearing and feeding.

Econazole

gyno-pevaril(3 pieces 420 rubles 15 pieces 800 rubles), Ifenek

Contraindications: hypersensitivity, pregnancy (1 tr.), since it penetrates into the systemic circulation, in 2-3 with caution, when feeding, breastfeeding should be stopped.
Side effects: local irritation, rash, itching.
Application: suppositories of 50 mg. within 14 days, even after the disappearance of symptoms, the course must be completed. Candles 150 mg. - within 3 days, if after 7 days the culture test gives a positive result, the course of treatment should be repeated.
Advantages and disadvantages: effective suppositories for thrush.

Natamycin - Pimafucin

Effect on the fetus: approved for use during pregnancy
Contraindications: increased individual sensitivity
Side effects: mild irritation
Mode of application: within 3-6 days, 1 suppository.
Advantages and disadvantages: the advantage of Pimafucin from thrush is the lack of effect on the fetus, so it is prescribed during pregnancy.

(30-60 rubles)
Complex preparations containing nystatin:

Polygynax (nystatin, neomycin, polymyxin B, price 6 pcs. 350 rubles, 12 pcs. 600 rubles),
Terzhinan (prednisolone, neomycin, ternidazole, nystatin - 6 pcs. 360 rubles, 10 pcs. 450 rubles), but their use is fraught with the development of dysbacteriosis.

Contraindications: pregnancy of any term, individual sensitivity
Side effects: chills, diarrhea, abdominal pain, vomiting, nausea
Mode of application: 2 r / day (morning and evening) for 10-14 days.
Pros and cons: The disadvantage of nystatin suppositories against candidiasis is a long course, use 2 times a day, the presence of serious side effects. The advantage is that they are cheap, candida does not develop resistance to nystatin, so it is often prescribed for chronic, recurrent candidiasis.

Povidone Iodine - Iodoxide

(10 pieces 300 rubles), Betadine(price 7 pieces 400 rubles, 14 pieces 500 rubles)

Contraindications: thyrotoxicosis, thyroid adenoma, with caution in renal failure, with individual sensitivity, during pregnancy is not recommended, contraindicated in the 1st trimester, in the 2nd-3rd trimester and during lactation - with caution.
Side effects: allergic manifestations, local hyperemia
Mode of application: In acute vaginitis 2 r / day for a week, 1 suppository, with chronic 1 r / day for 2 weeks, regardless of the phase of the menstrual cycle.
Pros and cons: the possibility of use during menstruation, is used in complex treatment for bacterial vaginosis.

Fenticonazole - Lomexin

(fenticonazole, price 1000 mg. 1 pc. 400 rub. 600 mg. 2 pcs. 600 rub)

Contraindications: pregnancy, can not be used during menstruation, with individual intolerance to the components of the suppository.
Side effects: mild symptoms of irritation that go away on their own and do not require discontinuation of the drug, allergic reactions - rash, urticaria, erythema
Mode of application: capsule 600 mg. are administered once, according to indications, if symptoms persist, it can be used for 3 days. Capsules 1000 mg. introduced within 2 days.
Advantages and disadvantages: effective remedy, can not be used during pregnancy.

Dequalinium chloride - Fluomizin

Fluomizin - vaginal tablets 6 pcs. 560 rub. - antiseptic in gynecology (bacterial vaginosis, candidal vaginitis, sanitation before childbirth and operations)

Contraindications: ulcerative lesions of the cervix and vagina, girls before the onset of sexual activity, pregnancy 1-2 trimester - there is no data on the safety of use
Side effects: symptoms of irritation, allergic reactions - rash, urticaria, erythema
Mode of application: capsule at night, for 6 days, stop treatment during menstruation, continue after.

In addition to suppositories, it is possible to use creams with antifungal drugs:

Clotrimazole - Candide (with an applicator 80 rubles), Clotrimazole cream 120 rubles, Canison 80 rubles.
Econazole - Ecodax cream 140 rubles
Isoconazole - Travogen cream 500-700 rubles.
Fenticonazole - Lomexin cream 600 rubles.
Butoconazole - Gynofort cream with applicator 600-700 rubles.

In chronic recurrent thrush, oral antifungal drugs are required:

Fluconazole 40-50 rubles (and more expensive analogues Flucostat, Mikomax, Mikosist, Diflucan)
Tinidazole 30-70 rub
Ketoconazole - Mycozoral 460 rubles
Itraconazole - Irunin 320 rubles, Itrazol 380 rubles, Orungamine.

After antifungal therapy, the doctor may prescribe drugs to normalize the vaginal microflora, that is, creating conditions for the growth of lactobacilli in the vagina:

Vagilak 2 r / day (candles with bifidobacteria) 5-10 days.
Laktozhinal, Atsilakt (lactobacilli) vaginal capsules for 1 to 10 days.
For oral administration - Bificol 10 days.

Advantages and disadvantages of using suppositories for thrush

Benefits of using topical preparations for candidiasis in women:

When the drug is injected into the site of active reproduction of fungi, the effect of local treatment appears much faster, especially when using modern effective drugs such as Livarol or Zalain.
Modern antifungal agents can be used once.
Since the systemic absorption of topical preparations is low, the incidence of side effects is reduced, in contrast to oral therapy.

Disadvantages of local treatment:

Local treatment gives a woman some inconvenience - soils underwear, limits her sexual life.
The positive effect of such therapy is possible only with mild forms of thrush, but when the course of the disease is more severe, prolonged, local therapy should be supplemented with the use of. Therefore, it is often necessary to repeat the course of treatment after a certain time.
When using combined antimicrobial drugs, such as Terzhinan, Polygynax, a frequent side effect is vaginal dysbacteriosis, which then requires additional treatment, for example, the use of suppositories with lactobacilli - Lactonorma, Acylact, Lactobacterin, Ecofemin or Vagiflora.

Candles from thrush during pregnancy

Very often in women during pregnancy, due to a physiological decrease in immunity, thrush occurs, and many drugs are either categorically impossible to use, or there have been no reliable safety studies for the fetus. Among the entire selection of local preparations, the following suppositories are approved for use:

Candles - Pimafucin, Primafungin (active ingredient Natamycin).
Combined drug - Macmirror complex (active ingredients Nystatin and Nifuratel).

In 2-3 trimesters Clotrimazole, Nystatin (low efficacy) or ancient Borax in glycerin (Sodium tetraborate in glycerin), Pimafucin, Gyno-Pevaril, Gynofort (vaginal cream), all of these drugs are used during pregnancy with caution if there is a potential risk maternal health outweighs the risk to the baby.

Some doctors prescribe a combination drug - Terzhinan (prednisolone, neomycin, ternidazole, nystatin), but the instructions for it indicate that from the 2nd trimester it can only be used when assessing the potential benefit to the mother and harm to the fetus, as it has undesirable side effects and contains a hormonal drug - prednisolone.

With vaginosis, which is provoked by Candida yeast-like fungus, doctors usually prescribe the drugs Clotrimazole or Pimafucin. Doctors consider them the most effective in this situation. But in order to determine which is more effective, it is necessary to study in detail the composition of each drug, as well as the spectrum of action and other features. What is better "Pimafucin" or "Clotrimazole" for thrush?

Properties

The effectiveness of therapy with one or another medication depends on the characteristics of the organism and the severity of the fungal infection. From what "Pimafutsin"?

In the body, fungi can appear in large numbers, which sometimes exceeds the permissible level. It is difficult to cope with this without pharmacological treatment. Specialized preparations help to significantly reduce their number. But at the same time, it is necessary to follow a diet, as well as hygiene rules and other advice from a medical specialist.

In order for the elimination of the fungus to be most effective, in addition to drug treatment, the diet should be adjusted.

One of the frequent indications for the use of Clotrimazole and Pimafucin is candidiasis. This is a fungal disease that appears in the absence of hygiene, as a result of chronic infections. Candidiasis happens:

nail;
vaginal;
oral.

Both drugs are based on imidazole and polyene antimicrobials. Substances of preparations help not so much to inhibit fungal activity as they do not allow the fungus to spread further. They are used in the treatment of fungal infections of the vagina, male member, and skin.

If we are talking about sexual diseases, then when one person is infected, both partners should undergo therapy. From what "Pimafutsin"? The active ingredients of the two drugs are different. The active trace element "Pimafucin" is natamycin, and in the second preparation - clotrimazole.

"Clotrimazole" is not suitable for general use, since it is instantly excreted from the body.

"Clotrimazole"

According to the instructions for use, Clotrimazole tablets appeared in the seventies of the last century. The active ingredient breaks the cell membrane of the fungus and key substances come out of it, which helps to eliminate fungal cells. The drug acts on various pathogens:

fungi Candida;
staphylococci;
streptococci.

Candida fungi are most sensitive to the drug. Clinical studies have confirmed that it is a safe and effective remedy for thrush.

According to the instructions for use, Clotrimazole tablets are not suitable for systemic treatment, since the drug is excreted from the body almost immediately, and an increase in dosage can provoke intoxication of the body.

"Pimafucin"

The active ingredient is natamycin, it is considered a natural antimicrobial agent. "Pimafucin" refers to antifungal drugs, it is produced by actinobacteria. Its effect is directed to ergosterol, with which the microelement binds, as a result of which it prevents the growth of fungal elements.

Natamycin is not absorbed by the mucous cavities of the gastrointestinal tract; with prolonged use of the drug, addiction to it does not appear.

"Pimafucin" eliminates such fungi:

nail;
vaginal;
cutaneous;
urethral.

Comparison of "Clotrimazole" and "Pimafucin" is based on the following statements.

Both drugs belong to the same therapeutic group - antifungal drugs. They differ in active ingredients. The drug based on natamycin has the following forms:

vaginal suppositories;
ointment;
capsules.

The second drug has more dosage forms. These are gel, cream, ointment, suppositories, vaginal tablets, topical solution, granules and powder. Both drugs were created to eliminate fungal infections.

How are medications similar?

"Pimafucin" and "Clotrimazole" have the following similar characteristics:

They are used to treat candidiasis and other fungal diseases in both mild and severe forms.
Dispensed from pharmacies without a prescription.
Various release forms.

Both drugs belong to the same therapeutic group.

What is the difference between "Clotrimazole" and "Pimafucin"

In addition to similar aspects, there are certain differences between the drugs. These include:

Natamycin has a milder effect and, when applied, practically does not penetrate into the blood.
"Pimafucin" can be used throughout pregnancy in the absence of sensitivity to substances, the second drug can be used in the second and third trimester.

The composition of "Pimafucin" and "Clotrimazole" includes different active ingredients. "Pimafucin" acts softer, during the application the drug practically does not penetrate into the blood. "Clotrimazole" does not have a release form in tablets for oral use.

The indications for taking the two medications also differ, but not significantly, and the likely adverse reactions also differ.

The cost of drugs is also different, but here the differences depend largely on the manufacturer. What are the instructions for use and the price of "Pimafucin" and "Clotrimazole"?

Russian-made drugs are much cheaper than foreign ones, but they have a similar effect. "Pimafucin" - from 200 to 700 rubles, "Clotrimazole" - from 20 to 260 rubles.

What is cheaper

The price and instructions for use for "Pimafucin" "Clotrimazole" depends on the manufacturer. For example, foreign-made Clotrimazole cream can cost up to two hundred rubles, and an ointment with the same name from a domestic manufacturer is somewhat cheaper. Another medicine in the form of a cream will cost more.

Differences also apply to the cost of the drug for vaginal use. For example, Clotrimazole vaginal tablets cost about fifty rubles, and suppositories with a different name cost up to five hundred rubles.

Which is better: "Clotrimazole" or "Pimafucin"

The pharmacological effect and the effect of the drug on healthy organs largely depend on how the body reacts to the substances of a particular drug. It is also necessary to consider whether patients have other diseases or pathological processes in which both medications are not recommended to be used, or it is possible, but under the strict supervision of a doctor.

With candidiasis

Both the one and the other medication are recommended for thrush. But it is difficult to determine exactly what works more efficiently. The impact depends on the form in which the disease proceeds - acute or recurrent, whether the person suffers from diabetes and other diseases.

With vaginal candidiasis, as a rule, local therapy is prescribed: suppositories, vaginal tablets, ointments.

If a woman is diagnosed with thrush, then she is prescribed local antifungal medications: suppositories, tablets, creams or ointments. In other situations, the decision is made by a medical specialist on an individual basis.

Actinomycosis (fungal infection)

When choosing a liniment from a skin fungus, one should take into account the characteristics of the body and the prohibitions on applying this or that medication. Both of these drugs are included. They work best when treating a yeast infection on the hands, feet and body.

Ointment "Clotrimazole" is considered a representative of the pharmacological group of antifungal drugs for external use. They are used for treatment that is aimed at eliminating the source of the infectious process caused by drug-sensitive pathogens.

Its antifungal effect consists in inhibiting the growth and spread of fungal cells, followed by their elimination due to disruption of the formation of ergosterol, which is the main component of the fungal cell wall.

This leads to a change in permeability, with its subsequent elimination and death of the fungal cell. At low concentrations, "Clotrimazole" inhibits the growth and reproduction of the fungus, at a higher dosage leads to the destruction and death of the fungal cell.

In a large dosage, the active component of the drug provokes a change in metabolic processes in the mitochondria of fungal cells with an increase in the intracellular level of hydrogen peroxide. The drug has increased activity against yeast-like and mold fungi, as well as dermatophytes, sources of pink lichen and erythrasma.

Cream "Pimafucin" refers to antifungal drugs of local action.

Liniment is an antimycotic antimicrobial agent with a broad spectrum of action. Under the influence of the active substance, the growth and spread of fungi and other pathogens sensitive to Natamycin is suppressed. The drug destroys the membrane of the fungus, gets inside and provokes the death of the pathological element.

The most sensitive to the drug are yeast-like fungi of the genus Candida, the least sensitive - dermatophytes.

There is no information on the use of the drug among children under the age of one year, therefore, before therapy, it is necessary to consult with a medical specialist. Which is better: "Clotrimazole" or "Pimafucin"?

When eliminating vaginal candidiasis in women, it is best to undergo therapy at the same time and her sexual partner, otherwise the disease will be transmitted to each other. During treatment with "Pimafucin" fungal infections of the genital organs, it is necessary to refrain from intimacy.

During pregnancy

For women during the "interesting position", experts usually recommend these drugs for treatment and prophylactic purposes to prevent thrush in the form of creams, vaginal suppositories or ointments.

But it must be borne in mind that "Pimafucin" should be used in all trimesters of pregnancy, and the second medication - only in the second and third trimester. In addition, suppositories can be prescribed before childbirth to reduce the risk of a fungal disease of the child when passing through the birth canal. It is difficult to determine exactly which is better: "Clotrimazole" or "Pimafucin" - both drugs are effective in their own way.

For women

Women use drugs in any form, usually for the treatment and prevention of candidiasis and other fungal infections. Especially for women, a medication has been developed in the form of vaginal suppositories.

For men

Both drugs are prescribed to men to prevent candidal balanoposthitis. With proper therapy, the disease completely disappears in fourteen days. When applying the cream "Pimafucin" itching and burning sensation decreases after a few days, the symptoms disappear completely within ten days. When using the second medication, they go away much faster - within about seven days.

In the human body, a certain amount of fungi of the genus Candida is constantly present. The overgrowth of this opportunistic fungus is controlled by certain bacteria and the human immune system.

In some cases, when the bacterial flora is disturbed, which occurs in the case of the use of antibacterial agents or when the protective functions of the body are weakened, the fungal flora is activated. Activation of the processes of reproduction of an opportunistic fungus leads to the appearance of candidiasis.

In some cases, the disease can appear up to 3-4 times a year. In such a situation, we can talk about the recurrent nature of the pathology. For the treatment of mycotic infection, drugs are used, which are based on imidazole and polyene antibiotics. The most popular and common are Clotrimazole and Pimafucin.

What is better Clotrimazole or Pimafucin? To get an answer to this question, drugs should be compared in terms of chemical composition and their effects on the body.

What is this article about?

What is the difference between the drugs?

Both drugs belong to the pharmacogroup of antifungal drugs. These drugs have noticeable differences in chemical composition. In Clotrimazole, the basis is the active ingredient of the same name, and the main active compound of Pimafucin is natamycin.

The form of release of both drugs may be different, due to the different ways of their application, which depend on the form of the disease.

Clotrimazole is produced in the form of an ointment, gel, cream. Solution for external use. In addition, vaginal suppositories and tablets for intravaginal use are produced.

Both drugs have excellent antifungal activity. Therefore, it is quite difficult to choose which one is better. The best option can only be determined by the attending physician, taking into account the study. At the same time, the dermatologist or mycologist also takes into account the individual characteristics of the patient's body when prescribing the drug.

Pimafucin is produced:

in the form of vaginal suppositories;
tablets intended for oral administration.

Medicines based on clotrimazole are produced by both domestic and foreign manufacturers. The most famous manufacturers of Clotrimazole in various forms are:

Sedate Health Care and Shreya Life Sciences is an Indian manufacturer.
Hyperion and Magistra C&C are a Romanian company.
GlaxoSmithKline Pharmaceuticals and Medana Pharma are manufacturers from Poland.
Akrikhin, Farmakor Production, Sintez and some others are domestic pharmaceutical companies.

Pimafucin is manufactured by the pharmaceutical company Astellas Pharma, and is marketed by the Italian company Temmler.

The difference in the effect on the body of natamycin and clotrimazole

Clotrimazole is an imidazole derivative. Its therapeutic effect has been clinically proven against dermatophytes, pathogenic yeast-like and dimorphic fungi, as well as against certain types of gram-positive bacteria. With the further development of pharmacology, when new compounds of the imidazole series were obtained, clotrimazole was used as a standard for the antimycotic activity of compounds.

When ingested, this substance contributes to the occurrence of disturbances in the processes that ensure the synthesis of one of the main components of the fungal cell wall - ergosterol. As a result of these phenomena, the membrane of the mycotic cell is destroyed. In addition, under the influence of clotrimazole, the synthesis of amino acids, phospholipids and sterols is stopped in the cell organelles, the listed negative phenomena occurring in the fungus lead to its death and destruction of cells.

Particularly sensitive to the effects of the drug are fungi belonging to the genus Candida. In addition, the drug based on clotrimazole can be successfully used in the fight against pityriasis versicolor. In a large number of clinical studies, clotrimazole has demonstrated itself as a safe medication with high antifungal efficacy when applied topically for the treatment of cutaneous and vaginal candidiasis. For systemic treatment, this compound is unsuitable, due to its rapid excretion from the body. Increasing the allowable dosage makes this drug toxic to humans.

Natamycin is a natural antibiotic. This compound is produced by actinobacteria belonging to the genus Streptomycetes. The main purpose of the substance when it enters the body is to disrupt the synthesis of ergosterol, which is required by the mycotic cell for the implementation of vital biochemical processes.

When penetrating into the focus of pathology, natamycin binds to ergosterol, which disrupts a large number of metabolic reactions in the cells of the fungus and leads to growth arrest and death.

Side effects and contraindications to the use of Pimafucin and Clotrimazole

The use of any antifungal compound of synthetic or natural origin in therapy can provoke the appearance of unwanted reactions in the patient. Such reactions may be the appearance of disorders in the functioning of the digestive tract, in addition, there may be disturbances in the work of the central nervous system. Quite often there is a decrease in the amount of hemoglobin in the blood.

During the initial period of treatment with Pimafucin, diarrhea may be recorded. Often the patient has a feeling of nausea. Usually, with further therapy, negative symptoms begin to slowly disappear.

With the local application of Pimafucin, an allergic response to the drug as a whole or to the components contained in it may occur.

The main relative contraindications to the use of Clotrimazole and Pimafucin are significant violations of the functionality of the kidneys and liver. In the presence of these pathologies, a visit to a dermatologist is required, who, after the examination, will correct the dosage of any of the drugs that is optimal for the patient.

It is forbidden to use both drugs for the treatment of mycotic lesions in the first trimester of pregnancy, and Clotrimazole ointment cannot be used to treat patients who are under three years of age.

Features of the impact on the body of drugs

Both drugs can be used to treat vulvovaginal candidiasis or thrush in women. However, it is impossible to say unequivocally which medicine is better. The positive effect of the drug depends on the severity of the disease and the presence of concomitant pathologies.

In primary candidiasis, it is preferable to use topical dosage forms in the form of a cream, vaginal tablets and suppositories.

When conducting research, it has been proven that in 87% the destruction of candida is achieved already 2 days after the use of Clotrimazole tablets, and 95% of the pathogenic flora is destroyed in the next few days.

When exposed to pathology with Pimafucin containing natamycin, about 88% of patients noted significant improvements in their condition. They lost the feeling of itching and other unpleasant sensations. 96% of women were cured of the disease already 6 days after the start of therapy with 2% natamycin cream.

Clotrimazole or Pimafucin, which is better for men?

According to statistics, about 10-11% of men suffer from candidiasis. For the treatment of this pathology, local forms of Clotrimazole and Pimafucin are used. The effectiveness of drugs has been proven in clinical trials.

When treating a fungal disease with Pimafucin cream, already after three days, 66% of patients experienced a decrease in the intensity of itching and burning. Patients were completely cured of the inflammatory process within 10 days. 100% recovery occurred in 97% of cases.

During clinical trials of Clotrimazole, 93% of men experienced relief, and the symptoms almost completely disappeared 7 days after the start of therapy. About 73% of male patients were completely cured of the disease a week after the start of a drug course of treatment for a fungal infection.

A good effect is exerted on the body during the treatment of recurrent pathology with Clotrimazole and Pimafucin in forms for local use, if combined with systemic antifungal drugs.

The cost of drugs, their analogues and reviews about them

Imported cream Clotrimazole in the territory of the Russian Federation has a cost of 160 to 185 rubles. Products of domestic manufacturers have a price 2-3 times lower. One tube of Pimafucin is much more expensive than Clotrimazole, its cost is twice as high.

Vaginal tablets have a price of about 50 rubles, Pimafucin in candles costs about 500 rubles for 6 pieces.

If hypersensitivity to clotrimazole or components of the drug is detected, it can be replaced with analogues. Such means are Candide, Nystatin, Terzhinan and some others.

Pimafucin analogues that can be used in the process of drug therapy are:

Pimafukort;
Primafungin;
Diflazon;
Lomexin;
Natacin;