Ksefokam pills or injections which is better. Tablets "Ksefokam": analogues and reviews

Xefocam(lornoxicam) is an analgesic and anti-inflammatory agent. The anti-inflammatory effect of lornoxicam is associated with the ability to inhibit the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase isoenzymes. It also inhibits the release of peroxidation products (free radicals) by activated leukocytes.

The analgesic effect is not associated with narcotic effects. Does not affect the opioid receptors of the central nervous system, respiratory function. Does not cause addiction and drug dependence.
After oral administration, it is almost completely rapidly absorbed from the gastrointestinal tract. Cmax is observed after 1-2 hours, in the case of parenteral administration - after 15 minutes. Bioavailability is 90-100%. The connection with the albumin fraction of proteins is 99%, which does not depend on the level of the drug in the blood.

Metabolite xephocam- hydroxylated lornoxicam - has no pharmacological action. In the body, the drug is completely metabolized. In plasma, lornoxicam is mainly present in the active form, and not in the form of a metabolite.
The half-life of lornoxicam does not depend on the level of drug concentration and is 4 hours. Metabolic products are excreted in the urine (33%), the rest - with bile. In gerontological patients, persons with hepatic and renal insufficiency, the pharmacokinetic properties of lornoxicam do not change.

Indications for use

It is used for pain syndrome of moderate and severe degree (pain in the muscles, radicular pain, pain in the spine, postoperative period), inflammatory and degenerative diseases of the musculoskeletal system (rheumatic lesions). In acute pain (lumbar ischialgia), injuries and in the postoperative period, parenteral (i / m / v) administration of the drug is indicated.

Mode of application

Tablets are taken orally, before meals, with water. With the severity of pain from moderate to significant, 8-16 mg / s are prescribed (divided into 2-3 doses). In case of pathology of a rheumatic nature, it is prescribed in an initial dose of 12 mg 2-3 r / s, then the dose is reduced to 8-16 mg / s in 2-3 doses. The duration of treatment is determined individually and depends on the course of the disease and the nature of the pain syndrome.

Patients with impaired functions of the gastrointestinal tract, kidneys and liver, gerontological patients (over 65 years old) are prescribed a maximum daily dose of 12 mg (3 times 4 mg).
Parenteral (intramuscular, intravenous) administration xephocam used in case of acute pain syndrome (postoperative period, sciatica, lumbago). The initial dose is 8-16 mg. In case of insufficient analgesic effect, 8 mg of the drug can be re-introduced at the same dose. The maximum daily dose is 16 mg per day. Maintenance dosage - 8 mg 2 times a day.
Dose adjustment is not required for patients with insufficient body weight (less than 50 kg), patients with gastrointestinal diseases, renal and hepatic insufficiency.

Before parenteral administration of the drug, 8 mg of dry matter should be dissolved in 2 ml of water for injection. The prepared solution is injected into a muscle or vein. The shelf life of the prepared solution is no more than 24 hours. When injected into a vein, the duration of the injection should be at least 15 seconds, intramuscularly - at least 5 seconds.

Side effects

Hematopoietic system: thrombocytopenia, leukopenia (rarely).
Central nervous system: headache, drowsiness, dizziness, insomnia, agitation, hallucinations, aseptic meningitis, migraine, syncope, peripheral neuropathy.
Sense organs: tinnitus, hearing loss, visual impairment, conjunctivitis.
Endocrine system: chills, fluctuations in body weight, sweating.
Cardiovascular system: increased blood pressure, peripheral edema, palpitations.
Gastrointestinal tract: dyspeptic symptoms (flatulence, abdominal pain, nausea, vomiting, dysphagia), peptic ulcers, bleeding (rectal and intestinal), dry mouth, hepatitis, stomatitis, colitis, glossitis, pancreatitis, changes in hepatic functions.
Urinary system: dysuric phenomena, nephrotic syndrome, crystalluria, glomerulonephritis, papillary necrosis, polyuria, renal failure.
Allergic reactions: rash, bronchospasm, shortness of breath, palpitations, exfoliative dermatitis, Steven-Johnson syndrome, angiitis, lymphadenopathy, allergic rhinitis.

Contraindications

hypersensitivity reactions to lornoxicam or other ingredients of the drug;
hypersensitivity or allergy to other non-steroidal anti-inflammatory drugs (ibuprofen, acetylsalicylic acid, indomethacin);
blood clotting disorders (hemorrhagic diathesis);
acute ulcers of the stomach and / or duodenum, nonspecific ulcerative colitis in the acute stage;
significant violations of hepatic functions;
kidney disease with a creatinine clearance of 300 µmol/l;
dehydration, hypovolemia;
hemorrhagic stroke;
bronchial asthma;
deficiency of glucose-6-phosphate dehydrogenase;
hearing loss;
age up to 18 years;
heart failure.

Pregnancy

Lornoxicam is contraindicated for use in pregnant women and women who are breastfeeding.

Interaction with other drugs

In combination with inhibitors of platelet aggregation and anticoagulants, the risk of bleeding and / or bleeding may increase.
Lornoxicam, when combined with sulfonylurea derivatives, potentiates the hypoglycemic effect of the latter.

In combination with non-steroidal anti-inflammatory drugs or glucocorticosteroids, the risk of gastrointestinal side effects increases. Lornoxicam enhances the effects of fibrinolytics.
Xefocam weakens the hypotensive effect of beta-adrenergic blockers, the diuretic and hypotonic effect of diuretics, angiotensin-converting factor inhibitors.
Nephrotoxic drugs (gold preparations, paracetamol, cyclosporine and others) provoke an increase in the likelihood of side effects from the kidneys.

The intake of alcohol, corticotropin, potassium-containing drugs increase the side effects on the gastrointestinal system.
Simultaneous administration of valproic acid, cephalosporins increases the likelihood of bleeding.

The concentration of lithium in the blood may increase with the simultaneous use of lithium and lornoxicam (the consequence of this are the toxic side effects of lithium).
When taken simultaneously with digoxin, renal clearance decreases. When combined with methotrexate, the content of the latter in the blood plasma increases.

Overdose

With an overdose, the side effects of lornoxicam increase. Therapy is symptomatic. Enterosorbents (activated charcoal) reduce the likelihood of overdose symptoms if taken immediately.

Release form

Tablets 4; 8 mg, 10 pcs. in a blister.
Lyophilized powder 8 mg in a vial for the preparation of a solution (complete with a solvent - 2 ml).

Storage conditions

Shelf life - no more than 5 years. Tablet forms should be stored out of the reach of children at a temperature of 15 to 25°C. Powder for the preparation of the injection form should be stored in a place protected from light and moisture at a temperature not exceeding 25°C. After dissolution, the drug can be used during the day.

Synonyms

Lornoxicam

Compound

Xefocam tablets:
active ingredients: lornoxicam - 4 or 8 mg in 1 tablet;
inactive ingredients: magnesium stearate, sodium croscarmellose, lactose, polyvidone K25, cellulose, talc, hypromellose, titanium dioxide.

Xefocam bottles– 8 mg as a lyophilized powder.

Additionally

In case of arterial hypertension and / or anemia, it is recommended to carefully evaluate all possible risks and benefits before prescribing the drug, since gastrointestinal bleeding, peptic ulcers, and the development of diabetes mellitus with impaired renal function are possible.
If necessary, take xephocam patients with gastrointestinal ulcers need additional administration of H2-receptor blockers, omeprazole.

When using Xefocam for a long time, you should be aware that the healing process of peptic ulcers will be inhibited. In the event of bleeding, it is necessary to immediately stop taking the drug and prescribe adequate therapy and emergency treatment. Careful medical supervision is necessary for patients with gastrointestinal pathology who are taking xefocam(especially for the first time).

When administered to patients with bleeding disorders or when used in combination with heparin (or other agents that reduce blood clotting), monitoring of blood coagulation parameters and bleeding time is necessary.
With hypovolemia, it can be used only against the background of adequate hydration (otherwise, there is a danger of reducing renal perfusion).

With the development of signs of nephropathy (arterial hypertension, edema, increased creatinine and urea in the blood serum), the drug should be discontinued (the threat of papillary necrosis, glomerulonephritis, acute renal failure).
In elderly patients, patients with arterial hypertension, obesity, people receiving diuretics, nephrotoxic drugs, it is necessary to monitor kidney function and blood pressure.

With prolonged use xephocam it is recommended to periodically conduct a clinical analysis of blood, kidney and liver tests.
When taking xefocam, you should not drink alcohol, drive a car and be involved in work that requires quick psychomotor reactions.

Main settings

Name:	KSEFOCAM
ATX code:	M01AC05 -

With exacerbation of osteochondrosis, attacks of arthralgia, diseases of the spine, even strong tablets and ointments do not completely stop the pain. Inflammation, destruction of the intervertebral discs, constant friction of the structures provokes a pronounced pain syndrome, which can only be overcome by formulations for parenteral use.

An effective drug to alleviate the painful symptoms of osteochondrosis - Ksefokam injections. Instructions for use indicate the main points associated with the injection, side effects, single and daily dosage, the permitted duration of the course.

Compound

Xefocam injections are a lyophilizate for solution preparation. Lornoxicam is a powerful analgesic active ingredient. On the basis of the lyophilisate, the health worker prepares the composition for inkjet administration. Among the additional substances are mannitol, trometamol, and other components.

The drug is placed in dark glass bottles. First aid kits receive package #5.

Xefocam injections are a powerful pain reliever with frequent side effects. In case of exacerbation against the background of rheumatic diseases and osteochondrosis, a short course of injections of Xefocam is first carried out, then the patient takes pills to reduce the negative effect on the body while maintaining a sufficient therapeutic effect.

Action

The analgesic effect is the result of the effect of lornoxicam on the production of prostaglandins. Fat-like components activate inflammatory processes of various kinds, provoke pain. The active substance of a non-narcotic analgesic blocks cyclooxygenase isoenzymes, the production and formation of inflammatory mediators stops quite quickly. The result is a stop of the inflammatory process.

The powerful analgesic effect of Xefocam is manifested with a double effect:

blocking the transmission of pain impulses from the affected area;
decrease in the strength of pain perception in the brain.

Therapeutic drug after Xefocam injections:

elimination of pain syndrome;
pronounced analgesic effect over a long period;
suppression of inflammation.

On a note! Advantages of the drug Xefocam: does not produce an opiate-like effect, does not form addiction and dependence, as with injections of narcotic analgesics. The drug does not cause persistent constipation, does not inhibit the activity of the respiratory center.

Indications for use

A powerful analgesic, Ksefokam is used to relieve pain in many diseases. Among the indications are not only the defeat of the musculoskeletal system, rheumatic diseases, but also other types of pathologies with a pronounced pain syndrome.

The drug based on lornoxicam is prescribed in the following cases:

relief of painful manifestations during exacerbation of gout, bursitis, arthritis, osteoarthritis, arthralgia,;
elimination of painful manifestations of dental, headache, migraine, sciatic pain;
reduction of discomfort in systemic lupus erythematosus;
anesthesia for extensive burns;
relief from ankylosing spondylitis;
the need for rapid relief of pain in the postoperative period.

Contraindications

It is strictly forbidden to use Ksefokam without the permission of physicians. A potent agent has many limitations, dose adjustment is required depending on the identified pathologies. Violation of the requirements of the instructions provokes negative phenomena, in case of an overdose, a negative effect on the digestive tract, nervous system, kidneys, and liver is possible.

Ksefokam injections are not prescribed if there are restrictions:

ulcerative nonspecific colitis;
pregnancy;
negative reaction to lornoxicam or additional substances;
bronchial asthma;
liver or kidney failure (severe form);
hypersensitivity to the components of drugs of the NSAID group;
exacerbation of peptic ulcer;
lactation period;
hearing loss;
the patient's age is up to 18 years;
hemorrhagic diathesis;
low blood clotting;
development of hemorrhagic stroke;
heart muscle damage.

Instructions for use and dosage

The solution for injection is prepared before using the drug. It is undesirable to keep the composition in the refrigerator, although the instructions indicate the possibility of storing the composition throughout the day. After this period, the drug can not be used.

To dilute the lyophilizate, use the liquid from the vial placed in the package. In the absence of the composition, special water for injection can be purchased at the pharmacy. Substitutes - saline, novocaine or lidocaine. It is important to ensure that the powder is completely dissolved. Ready solution for intramuscular or intravenous administration is yellow.

for the fastest pain relief during an attack, a double dose of an analgesic of 16 mg is initially administered;
maintenance dosage - 1 vial (8 mg). The drug is administered twice a day;
the maximum dosage for 24 hours is 2 vials or 16 mg;
For elderly patients, doctors recommend a reduced dosage - half the daily norm: at first - 8 mg, a maintenance dose - twice a day, 4 mg;
Ksefokam prescribes injections of the drug in a short course - from three to seven days. When stopping acute pain, you need to replace injections with powerful analgesic tablets.

Important! A health worker should give injections of a powerful anesthetic: the drug requires careful handling, strict adherence to the rules for administering the composition. Do injections intramuscularly or intravenously - the doctor decides.

Overdose

Violation of a single or daily norm provokes severe reactions:

development of liver and kidney failure;
problems with coordination of movements;
convulsive syndrome;
risk of bleeding;
dizziness, loss of consciousness;
severe nausea, vomiting.

Possible side effects

A powerful analgesic quickly relieves pain, but often negatively affects different parts of the body. The instruction prohibits the uncontrolled use of the drug to rule out severe reactions.

Possible side effects on the background of injections of the drug Ksefokam:

sleep disturbance;
excessive excitement or drowsiness, inhibition of reactions;
depression;
violation of speech functions;
digestive disorders;
stomach pain, nausea, vomiting;
inflammation of the colon;
flatulence;
constipation or diarrhea;
inflammation of the pancreas;
irritation of the oral mucosa, esophagus and stomach;
neuropathy causing problems with motor skills;
deterioration in hearing acuity, a feeling of constant tinnitus;
bleeding in the gastrointestinal tract;
hallucinations;
short-term loss of consciousness against the background of a decrease in muscle tone;
headaches, including migraines, dizziness.

Go to the address and read about the probable causes of development and features of the treatment of deforming spondylarthrosis of the thoracic spine.

drug interaction

Complex therapy is possible only after an analysis of possible adverse reactions, ascertaining the patient's state of health. It is undesirable to combine Ksefokam with NSAIDs, antihypertensive, antithrombotic compounds, antidepressants, blood sugar control compounds, diuretics.

Price

Estimated price of Ksefokam in injections is from 700 to 760 rubles. The package contains 5 vials of 8 mg.

The shelf life of the analgesic is 5 years. Keep vials with lyophilizate in a dry place, in closed packaging. Temperature - up to +25 C.

Ksefokam: analogues

To relieve pain, suppress the synthesis of prostaglandins, other names of the group of NSAIDs with active analgesic and anti-inflammatory effects are used:

Liberum.
Amelotex.
Meloflex Rompharm.
Movalis.
Tesamen.
Mesipol.
Melbek and Melbek-Forte.

From this medical article you can get acquainted with the drug Xefocam. The instructions for use will explain in which cases you can take pills and injections, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Ksefokam, from which you can find out whether the medicine helped in the treatment of various pain syndromes in adults and children. The instructions list the analogues of Xefocam, the price of the drug in pharmacies, as well as its use during pregnancy.

Xefocam is a non-steroidal anti-inflammatory drug. Instructions for use recommend taking 4 mg and 8 mg Rapid tablets, injections in ampoules for injection for short-term treatment of moderate to severe pain; in inflammatory and degenerative diseases of the musculoskeletal system.

Release form and composition

Pharmacies receive 4 mg and 8 mg coated tablets (Ksefokam Rapid).

The instruction informs that the second dosage form is a lyophilisate for preparing a solution for intravenous and intramuscular administration (injections in ampoules for injection).

The active substance is lornoxicam. Its volume in tablets reaches 4 or 8 mg. Lifilizat contains 8 mg of the active ingredient in a vial.

pharmachologic effect

The drug has an analgesic and anti-inflammatory effect. The anti-inflammatory effect of lornoxicam is due to inhibition of the activity of cyclooxygenase isoenzymes, which inhibits the synthesis of prostaglandins. Ksefokam, instructions for use confirms this, inhibits the release of free radicals by activated leukocytes.

The analgesic effect of the drug is not associated with narcotic effects. The drug does not affect the opioid receptors of the central nervous system, does not depress breathing, does not cause the effect of addiction and drug dependence.

The active substance is rapidly absorbed from the gastrointestinal tract and completely metabolized in the liver. The drug is excreted in the form of metabolites mostly with bile, partly by the kidneys.

What helps Ksefokam?

Indications for the use of the drug include:

symptomatic therapy of rheumatoid arthritis and osteoarthritis;
short-term treatment of pain syndrome in injuries and after surgical interventions;
sciatica;
algomenorrhea.

Instructions for use

Xefocam tablets are taken orally. They contain 4 mg or 8 mg of lornoxicam.

For rheumatic diseases, as well as for maintenance therapy, the instruction recommends taking Ksefokam twice a day, 4-8 mg, depending on the patient's well-being.

With moderate or severe pain, 16 mg of the drug is prescribed per day, divided into two doses. On the first day of treatment, if necessary, an additional 16 mg may be used.

Ksefokam injection solution can be administered intravenously (at least 15 seconds) and intramuscularly (at least 5 seconds). To prepare a solution for injection, take 8 mg of dry powder and dilute in 2 ml of solvent.

Injections are used for acute pain syndrome: the recommended dose is 8 mg, with an insufficient analgesic effect, 8 mg of the drug is administered repeatedly. Maintenance therapy involves the use of Xefocam 2 times a day, 8 mg.

For patients with renal or hepatic insufficiency, diseases of the digestive tract, weighing less than 50 kg, dose adjustment is not required.

Contraindications

children and adolescents under 18 years of age (due to the lack of clinical data on the use of the drug in this age group);
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history);
pregnancy;
breastfeeding period;
thrombocytopenia;
hypersensitivity or allergy to the components of the drug Ksefokam, from which tablets and injections can cause side effects;
liver failure or active liver disease;
inflammatory bowel disease (Crohn's disease, UC) in the acute phase;
heart failure in the stage of decompensation;
severe renal failure (serum creatinine more than 300 µmol / l), progressive kidney disease, confirmed hyperkalemia, hypovolemia or dehydration;
hemorrhagic diathesis or bleeding disorders, as well as after operations associated with a risk of bleeding or incomplete hemostasis;
recurrent stomach ulcer or repeated bleeding from the gastrointestinal tract;
data on previous bleeding from the gastrointestinal tract associated with taking NSAIDs;
erosive and ulcerative changes in the gastric mucosa or duodenum, active gastrointestinal bleeding; cerebrovascular or other bleeding;
period after coronary artery bypass grafting.

Side effects

Children, during pregnancy and lactation

Ksefokam pregnant and lactating women are not prescribed. Should not be used by women during pregnancy planning. For children under 18 years of age, the medication is contraindicated.

special instructions

Caution should be exercised when treating Xefocam in patients who smoke and abuse alcohol.

In the case of arterial hypertension or anemia, before using the drug, it is necessary to weigh the possible risks and benefits of therapy, since the development of gastrointestinal bleeding, peptic ulcers, diabetes mellitus with impaired renal function is possible.

Against the background of long-term use of lornoxicam, the healing of peptic ulcers slows down. In case of bleeding, it is necessary to stop taking the drug and apply adequate therapy.

drug interaction

In combination with anticoagulants or inhibitors of platelet aggregation, an increase in bleeding time is possible. Therefore, MHO control is required.

In combination with beta-blockers and ACE inhibitors, their hypotensive effect may decrease. In combination with diuretics, the diuretic effect and hypotensive effect are reduced.

Xefocam's analogs

The structure analogue is the drug Ksefokam Rapid. According to the pharmacogroup, analogues are distinguished:

Holiday conditions and price

The average price of Ksefokam (tablets 4 mg No. 10) in Moscow is 117 rubles. In Kyiv, you can buy medicine for 55 hryvnia, in Kazakhstan - for 660 tenge. In Minsk, pharmacies offer the drug for 8-9 bel. rubles. It is released from pharmacies by prescription.

Indications for use:
It is used for pain syndrome of moderate and severe degree (pain in the muscles, radicular pain, pain in the spine, in the postoperative period), inflammatory and degenerative diseases of the musculoskeletal system (rheumatic lesions). In case of acute pain (lumbar ischialgia), injuries and in the postoperative period, parenteral (i / m / v) administration of the product is indicated.

Pharmachologic effect:
Xefocam (lornoxicam) is an analgesic and anti-inflammatory drug. The anti-inflammatory effect of lornoxicam is associated with the ability to inhibit the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase isoenzymes. It also inhibits the release of peroxidation products (free radicals) by activated leukocytes.

Xefocam's metabolite, hydroxylated lornoxicam, has no pharmacological action. In the body, the product is completely metabolizable. In plasma, lornoxicam is mainly present in the active form, and not in the form of a metabolite.
The half-life of lornoxicam does not depend on the concentration level of the drug and is 4 hours. Metabolic products are excreted in the urine (33%), the rest - with bile. In gerontological patients, persons with hepatic and renal insufficiency, the pharmacokinetic properties of lornoxicam do not change.

Ksefokam method of administration and dose:
Tablets are taken orally, before meals, with water. With the severity of pain from moderate to significant, 8-16 mg / s are prescribed (divided into 2-3 doses). In case of pathology of a rheumatic nature, it is prescribed in the initial dose of 12 mg 2-3 r / s, then the dose is reduced to 8-16 mg / s in 2-3 doses. The duration of treatment is determined individually and depends on the course of the disease and the nature of the pain syndrome.

Patients with impaired functions of the gastrointestinal tract, kidneys and liver, gerontological patients (over 65 years old) are prescribed a maximum daily dose of 12 mg (3 times 4 mg).
Parenteral (intramuscularly, intravenously) administration of xefocam is used in case of acute pain syndrome (postoperative period, sciatica, lumbago). The initial dose is 8-16 mg. In case of insufficient analgesic effect, 8 mg of the product can be administered again at the same dose. The maximum daily dose is 16 mg per day. Maintenance dosage - 8 mg 2 times a day.
Dose adjustment is not required for patients with insufficient body weight (less than 50 kg), patients with gastrointestinal diseases, renal and hepatic insufficiency.

Before parenteral administration of the product, 8 mg of dry matter should be dissolved in 2 ml of water for injection. The prepared solution is injected into a muscle or vein. The storage period of the prepared solution is no more than 24 hours. When injected into a vein, the duration of the injection should be at least 15 seconds, intramuscularly - at least 5 seconds.

Ksefokam contraindications:
hypersensitivity reactions to lornoxicam or other ingredients of the product;
hypersensitivity or allergy to other non-steroidal anti-inflammatory drugs (ibuprofen, acetylsalicylic acid, indomethacin);
blood clotting disorders (hemorrhagic diathesis);
acute ulcers of the stomach and / or duodenum, nonspecific ulcerative colitis in the acute stage;
significant violations of hepatic functions;
kidney disease with a creatinine clearance of 300 µmol/l;
dehydration, hypovolemia;
hemorrhagic stroke;
bronchial asthma;
deficiency of glucose-6-phosphate dehydrogenase;
hearing loss;
age up to 18 years;
heart failure.

Xefocam side effects:
Hematopoietic system: thrombocytopenia, leukopenia (not often).
Central nervous system: headache, drowsiness, dizziness, insomnia, agitation, hallucinations, aseptic meningitis, migraine, syncope, peripheral neuropathy.
Sense organs: tinnitus, hearing loss, visual impairment, conjunctivitis.
Endocrine system: chills, fluctuations in body weight, sweating.
Cardiovascular system: increased blood pressure, peripheral edema, palpitations.
Gastrointestinal tract: dyspeptic symptoms (flatulence, abdominal pain, nausea, vomiting, dysphagia), peptic ulcers, bleeding (rectal and intestinal), dry mouth, hepatitis, stomatitis, colitis, glossitis, pancreatitis, changes in hepatic functions.
Urinary system: dysuric phenomena, nephrotic syndrome, crystalluria, glomerulonephritis, papillary necrosis, polyuria, renal failure.
Allergic reactions: rash, bronchospasm, shortness of breath, palpitations, exfoliative dermatitis, Steven-Johnson syndrome, angiitis, lymphadenopathy, allergic rhinitis.

Pregnancy:
Lornoxicam is contraindicated for use in pregnant women and women who are breastfeeding.

Overdose:
With an overdose, the side effects of lornoxicam increase. Therapy is symptomatic. Enterosorbents (activated charcoal) reduce the likelihood of overdose symptoms if taken immediately.

Use with other medicinal products:
In combination with inhibitors of platelet aggregation and anticoagulants, the risk of bleeding and / or bleeding may increase.
Lornoxicam, when combined with sulfonylurea derivatives, potentiates the hypoglycemic effect in the aftermath.

In combination with non-steroidal anti-inflammatory drugs or glucocorticosteroids, the risk of gastrointestinal side effects increases. Lornoxicam enhances the effects of fibrinolytics.
Ksefokam weakens the hypotensive effect of beta-adrenergic blockers, the diuretic and hypotonic effect of diuretics, angiotensin-converting factor inhibitors.
Nephrotoxic products (gold products, paracetamol, cyclosporine and others) provoke an increase in the likelihood of side effects from the kidneys.

The intake of alcohol, corticotropin, potassium-containing products increase the side effects on the gastrointestinal system.
Simultaneous administration of valproic acid, cephalosporins increases the likelihood of bleeding.

The concentration of lithium in the blood may increase with the simultaneous use of lithium products and lornoxicam (the consequence of this is the toxic side effects of lithium).
When taken simultaneously with digoxin, renal clearance decreases. When combined with methotrexate, the content of the latter in the blood plasma increases.

Release form:
Tablets 4; 8 mg, 10 pcs. in a blister.
Lyophilized powder 8 mg in a vial for the preparation of a solution (complete with a solvent - 2 ml).

Storage conditions:
Storage period - no more than 5 years. Tablet forms should be stored out of the reach of children at a temperature of 15 to 25°C. Powder for the preparation of the injection form should be stored in a place protected from light and moisture at a temperature not exceeding 25°C. After dissolution, the product can be used throughout the day.

Synonyms:
Lornoxicam

Ksefokam composition:
Xefocam tablets:
active ingredients: lornoxicam - 4 or 8 mg in 1 tablet;
inactive ingredients: magnesium stearate, sodium croscarmellose, lactose, polyvidone K25, cellulose, talc, hypromellose, titanium dioxide.

Xefocam vials - 8 mg in the form of a lyophilized powder.

Additionally:
In case of arterial hypertension and / or anemia, it is recommended to carefully evaluate all possible risks and benefits before prescribing the product, since gastrointestinal bleeding, peptic ulcers, and the development of diabetes mellitus with impaired renal function are possible.
If it is necessary to take xefocam, patients with gastrointestinal ulcers need additional administration of H2-receptor blockers, omeprazole.

When using xefocam for a long time, you should know that the healing process of peptic ulcers will be inhibited. In the event of bleeding, it is necessary to immediately stop taking the product and prescribe adequate therapy and emergency treatment. Careful medical monitoring is required for patients with gastrointestinal pathology who take xefocam (especially for the first time).

When prescribed to patients with bleeding disorders or when used in combination with heparin (or other drugs that reduce blood clotting), monitoring of blood coagulation parameters and bleeding time is necessary.
With hypovolemia, it can be used only against the background of adequate hydration (otherwise, there is a danger of reducing renal perfusion).

With the development of signs of nephropathy (arterial hypertension, edema, increased creatinine and urea in the blood serum), the drug should be discontinued (the threat of papillary necrosis, glomerulonephritis, acute renal failure).
In elderly patients, patients with arterial hypertension, obesity, people receiving diuretics, nephrotoxic products, it is necessary to monitor kidney function and blood pressure.

With prolonged use of xefocam, it is recommended to periodically conduct a clinical blood test, kidney and liver tests.
When taking xefocam, you should not drink alcohol, drive a car and be involved in work that requires quick psychomotor reactions.

Attention!
Before using the medication "Xefocam" it is necessary to consult a doctor.
The instructions are provided solely for familiarization with " Xefocam».

22 reviews

Sort

by date

I had to interrupt the treatment due to skin rashes and stomatitis on the tongue. When used, the pain goes away, and when the effect of the drug wears off, you feel like Cinderella after midnight. Everything falls into place and the pain returns.

Ksefokam well stopped the pain after a rib injury, neuralgia, BUT after that the leg hurts very much from the side of the injection. I won’t bet again, I’m afraid my leg will fall off completely.

I am 71 years old. Chronic spondylosis, arthritis, intervertebral hernia (3 pieces). Chronic pain. There has been an escalation recently. On the recommendation of a doctor, I tried several drugs (intramuscularly) until they tried Xefocam. Literally from one time - an excellent result! They made 5 injections - everything is in order. The pains are gone, I have not noticed any side effects (so far).

My mother, a sick spine, went to the hospital and took an x-ray, they said that it was an ordinary handoros, they attributed her to xefocams and combilipenes. They pierced Xefocam for 3 days and her stomach began to hurt very badly, and on the fourth day after the injections, her pressure dropped sharply and she fainted.

My mother has gangrene of the lower extremities, the doctor prescribed xefocams, I don’t know if it will help or not? She's in a lot of pain

I have frequent severe pain in the spine, postoperative hernia. And then there was a pinched sciatic nerve. The neuropathologist prescribed Xefocam intramuscularly. Of course, the drug has a strong analgesic effect. Within a week of use, the pain was completely gone. But xefokam is not cheap, I ordered it under the ASNA program https://www.asna.ru/catalog/ksefokam_4mg_n30_tab_pokrytye_plenochnoy_obolochkoy_takeda.html. There are huge savings if... I have frequent severe pain in the spine, postoperative hernia. And then there was a pinched sciatic nerve. The neuropathologist prescribed Xefocam intramuscularly. Of course, the drug has a strong analgesic effect. Within a week of use, the pain was completely gone. But xefokam is not cheap, I ordered it under the ASNA program https://www.asna.ru/catalog/ksefokam_4mg_n30_tab_pokrytye_plenochnoy_obolochkoy_takeda.html. It turns out a huge savings if you order any medicines in the amount of 3,000 rubles or more together with xefocam.

I was prescribed a drug for severe pain in the spine (Schmorl's hernia, protrusion, arthrosis of the lumbocostal joints). It became a little easier on the 5th day, on the 9th day of taking the drug (intramuscularly) there were severe pains in the stomach (exacerbation of the ulcer). As the saying goes - one - we treat, another - we cripple.

I started having terrible pains in my spine, to the point that I had to call an ambulance. After the examination, they told me that I had a hernia. The main treatment was prescribed, and Ksefokam was prescribed for pain relief. The drug is very good as a pain reliever. But you can’t take it for a long time, it gives side effects. I took it for a week, then it got better .... I started having terrible pains in my spine, to the point that I had to call an ambulance. After the examination, they told me that I had a hernia. The main treatment was prescribed, and Ksefokam was prescribed for pain relief. The drug is very good as a pain reliever. But you can’t take it for a long time, it gives side effects.
I took it for a week, then it got better.
Ksefokam now, just in case, I always have at hand.

Today I had an X-ray of my lower back. Found the displacement of the disc vertebrae. Prior to that, on Monday I was at the reception and they prescribed injections of artrosan, midakam and combilepen. So far I have had 5 injections. There are no improvements. And in the evening they made xefocam. I thought I would die. such was the pain, it burns with fire, as if they were cut to the living. Still... Today I had an X-ray of my lower back. Found the displacement of the disc vertebrae. Prior to that, on Monday I was at the reception and they prescribed injections of artrosan, midakam and combilepen. So far I have had 5 injections. There are no improvements. And in the evening they made xefocam. I thought I would die. such was the pain, it burns with fire, as if they were cut to the living. Until now, it has not subsided, right up to tears. I don't know how I will sleep at night.