Metronidazole in the treatment of gynecological diseases. The use of metronidazole suppositories in urological practice

Anti-inflammatory drugs in the form of suppositories are prescribed for various diseases of the organs of the female reproductive system. Some gynecological suppositories are used vaginally, others - rectally. But in general, the list of gynecological suppositories is very wide.

Anti-inflammatory drugs in gynecology are always prescribed if an inflammatory process is noted. They are widely used, but at the same time, like other medicines, vaginal and rectal suppositories have certain disadvantages.

Suppositories as a dosage form

suppositories - one of the best medicines that can effectively cure women's diseases. Candles are used for the prevention of female diseases, as well as for their treatment. The composition includes a base, which gives the product the shape of a candle, as well as a medicinal substance. The main feature of such a drug is that its form is preserved at room temperature, and turns into a liquid form when body temperature is noted.

Anti-inflammatory vaginal suppositories prescribed for various diseases of the female reproductive system. Vaginal suppositories are also used to prevent such diseases. In particular, vaginal suppositories are prescribed from inflammation of the ovaries , antiviral suppositories for women, etc.

Despite the fact that the list of vaginal suppositories is very large, their names are known to many, and in pharmacies most of these drugs are sold without a prescription, the doctor should tell you individually about which antibacterial or antiviral drugs to use.

It is very important to know how to properly administer suppositories. How to use this form of medicine is indicated in the instructions. But how to put candles may differ, depending on the drug. For example, some suppositories are recommended to be used at bedtime, once a day.

To properly insert candles, you need to take a prone position, wash your hands first. Also, before you enter the medicine, you need to prepare a sanitary napkin.

All candles are usually divided into different types depending on where they are introduced:

The main advantage of using this form of medication is that the active substance enters the bloodstream relatively quickly (about half after half an hour, 100% after an hour). However, it does not enter the gastrointestinal tract and is not destroyed in the liver. Also, vaginal suppositories have not only a general, but also a local effect.

In addition, the application process is very simple and occurs without pain, suppositories very rarely cause allergic manifestations.

Candles for colpitis

Need to know for those who are interested in what it is in gynecology, that this is a disease in which an inflammatory process of the vaginal mucosa occurs. The treatment of colpitis in women depends on which infectious agent provoked the inflammation. So, colpitis (vaginitis) can be like specific (fungal , trichomonas , gonorrheal etc.), and non-specific (streptococcal , staphylococcal , polymicrobial ). It is depending on the type of infections that drugs are selected for the treatment of colpitis, in particular, suppositories from colpitis .

Main features vaginitis - Discomfort in the vulva, a feeling of severe itching and burning. The amount of discharge with an unpleasant odor increases, the temperature may rise, pain in the lower abdomen occurs, problems with urination appear.

In this situation, it is important to use properly selected suppositories for vaginitis, which help not only get rid of the symptoms, but also completely cure vaginitis by suppressing the activity of pathogenic microorganisms.

In the first days of the disease, douching should be carried out using antiseptic agents (, Ppotassium germanate , Bicarbonate of soda ). Herbs are also used for this purpose - they douche with chamomile, sage, lemon balm,

In parallel with douching, you can insert suppositories into the vagina. The doctor selects such suppositories that demonstrate activity in relation to the type of pathological microflora that provoked the disease. Therefore, before prescribing treatment, the gynecologist conducts a study to determine which drugs should be taken.

Nonspecific vaginitis

If the patient is diagnosed nonspecific colpitis , she is prescribed broad-spectrum antibacterial vaginal suppositories or antiseptics.

The following suppositories can be prescribed, which cure the inflammatory process in gynecology.

After the first stage of treatment has been completed, and the activity of the fungi has been suppressed, a second stage of therapy must be carried out to restore the normal flora of the vagina. It is important that normal conditions are created for the active reproduction of lactobacilli to occur.

During this period, a woman is prescribed:

• Candles containing . The drug is intended for the normalization of microflora. Bifidumbacterin is used for up to 10 days, 1 supp. in a day.
• (with dried bifidobacteria) you need to use 1 supp every day. within up to 10 days.
• apply within 10 days, 1 supp. Acylact for the night. Candles are also given Vagilak .
• The drug contains lactobacilli, 1 capsule is injected into the vagina. morning and evening, treatment lasts up to 10 days.
• Also in the process of treatment, you can use, Bificol , in ampoules. The contents of the ampoules must be diluted with water and intravaginally injected tampons with this liquid.

Anti-inflammatory suppositories in gynecology

Currently, the list of names of drugs with anti-inflammatory action is very large. Such drugs are used to treat inflammation, as additional funds in the treatment regimen, which also includes tablets, injections, herbs, etc. All names of suppositories for inflammation that are offered in pharmacies should be reported to the doctor so that he prescribes the most effective treatment.

Often, as part of a comprehensive treatment regimen, they are also present in gynecology. Antibacterial drugs effectively complement local drugs in the form of suppositories.

Ichthyol suppositories in gynecology

Despite the simplicity of this drug on a natural basis, reviews of in gynecology are almost always positive, as it acts effectively. The active substance is ichthyol.

These analgesic suppositories are used if the treatment of inflammatory diseases is necessary, as well as to accelerate the healing of injuries and ulcers of the mucosa. Medicines containing ichthyol are suitable for both women and men (rectally).

If necessary, they are also used in veterinary medicine - for the treatment of dogs.

Methyluracil suppositories in gynecology

They are used to treat a variety of gynecological diseases. Accelerate the renewal of the epithelium, heal damaged skin, stimulate metabolic processes. They produce an anti-inflammatory effect, are used as an additional tool in the treatment of cervical erosion.

Sea buckthorn suppositories in gynecology

Sea buckthorn suppositories are widely used in gynecology.

They are suitable for use in the treatment mucosal injuries , at dysbacteriosis . Reviews indicate that suppositories with sea buckthorn in gynecology are very effective. Moreover, they can be used at any age - senile or too young age is not a contraindication. Treatment with this drug during pregnancy is also allowed.

Candles with calendula

When choosing antimicrobials, one should not forget about candlelight with calendula . After all, calendula has an antimicrobial, anti-inflammatory, wound-healing effect. The instruction indicates that this dosage form rarely causes side effects.

Vaginal suppositories are used for the treatment of inflammatory processes, atrophic colpitis, cervical erosion.

Indomethacin suppositories in gynecology

This medicine, blocking the synthesis of prostaglandins, anesthetizes, lowers the temperature, relieves inflammation. They are prescribed for, with inflammation of the ovaries, with pain.

Also Indomethacin suppositories effective in reducing the formation of adhesions.

Candles Betiol

In gynecology, candles, which include belladonna and ichthammol, are used as an antiseptic. They are used rectally, with. But sometimes, during the planning of pregnancy, the doctor prescribes suppositories, which include belladonna, in order to influence the basal temperature.

Synthomycin suppositories

it is used if the pelvic organs are affected by staphylococci, chlamydia, streptococci and other bacteria.

They are assigned at vaginitis and others. Synthomycin has practically no systemic effect on the body. Synthomycin is administered intravaginally twice a day. How long to use the drug, the doctor determines, but, as a rule, the treatment lasts up to 10 days.

Candles Kyzyl-May

The composition includes herbs, sea buckthorn oil, cocoa butter, bentonite, beeswax. Candles improve tissue regeneration, have an anti-inflammatory effect.

Assign when colpitis , cervicitis , erosion . It is necessary to apply rectally 1-2 supp. per day, treatment lasts up to 15 days. Cost - from 600 rubles.

Candles for adnexitis, endometriosis

The instructions for many drugs in the form of suppositories indicate the names of female gynecological diseases. After all, antibiotics for gynecological diseases in the form of tablets, as well as injections, must be supplemented with local remedies.

Treatment should be carried out according to the scheme prescribed by the specialist. It is important that antibiotics for adnexitis are chosen correctly. After all, inflammatory diseases of the reproductive system can provoke specific ( chlamydia , gonorrhea , trichomoniasis ) and non-specific microorganisms.

• Adnexitis - inflammation of the appendages, in which a woman feels pain in the groin area. Pain can be cutting, dull, aching.
• - an inflammatory process of the uterus, in which there are pains of a different nature in the lower abdomen. Most often, this disease develops after intrauterine interventions ( scraping , operational childbirth).

As with adnexitis , as well as endometritis a woman may have a rise in body temperature, other signs of intoxication are noted.

At endometriosis often used drugs aimed at restoring the immune status. How to treat endometriosis - drugs or other methods, the doctor determines after examination and establishing an accurate diagnosis. Treatment of endometriosis involves the use of the drug with interferon and vitamin E and C. Rectal suppositories are used for pain relief - NSAIDs .

For the purpose of resorption of adhesions, a drug is used. Candles Terrilithin and others are prescribed to reduce inflammation. It is also sometimes advisable to take pills - Curantyl and etc.

Treatment of inflammation of the uterus and appendages involves, first of all, antibiotics, suppositories are also used for inflammation of the female organs. The use of suppositories is practiced for different purposes.

Rectal suppositories for inflammation of the appendages with anti-inflammatory action, as a rule, contain NSAIDs. They provide anti-inflammatory, antipyretic, analgesic effect. Drugs that belong to the group of NSAIDs suppress the synthesis of prostaglandins, which are formed in large quantities during inflammatory processes and provoke pain.

The use of rectal suppositories begins at the same time as the patient begins to drink antibiotics. Treatment continues from 7 to 10 days. As a rule, they are assigned Movalis , and etc.

• appoint once, it is necessary to apply in the evening.
• Movalis (active component meloxicam ) apply once at bedtime, 7 days.
• Voltaren apply in the evening and in the morning.
• diclofenac , Diklovit - once a day.
• Candles with belladonna - 1-3 times a day.
• Flexen , Flamax (active ingredient ketoprofen) is used once, 7 days. There is also the name "Alamaks". However, the correct name for candles is not Alamax, but Flamax.

Modern gynecology offers a fairly wide list of rectal anti-inflammatory suppositories, but any painkillers and anti-inflammatory suppositories should be prescribed by a doctor in the general treatment regimen. If you need additional painkillers in tablets, it should also be selected by a specialist.

Also, anti-inflammatory suppositories for women with endometritis and adnexitis are prescribed intravaginally. Like anti-inflammatory rectal suppositories, they need to be used regularly. The purpose of the use of such drugs is the sanitation of the vagina, the suppression of the anaerobic flora.

Prescribed for such diseases Terzhinan And Fluomizin (active component metronidazole). Terzhinan and Fluomizin should be used up to 10 days, 1-2 supp. every day.

When the main therapy with anti-inflammatory drugs is completed, it is very important to normalize the vaginal biocenosis. For this purpose, both those preparations that contain bifidobacteria and lactobacilli, and Longidase suppositories are used.

Longidaza provides a proteolytic effect. These are effective prophylactic suppositories, as they prevent the appearance of adhesions, and also dissolve existing ones. Longidaza stabilizes the function of the immune system, also provides an antioxidant and anti-inflammatory effect. This drug is also prescribed for ovarian cysts. Candles should be used rectally, before going to bed. The course of therapy lasts up to 3 weeks.

Candles for cervical erosion

is a very common disease among women. It develops if desquamation of the stratified squamous epithelium occurs in the vaginal part of the cervix. In its place, the cells of the cylindrical epithelium multiply, which lines the cervical canal. Ectopia of the cervix is the correct name for this disease.

For those who are looking for candle names from cervical erosion , it should be noted that the treatment of this disease is as follows: the pathological area is destroyed by electrical, chemical, laser methods. Before and after cauterization, suppositories are prescribed for the treatment of cervical erosion. Before cauterization by laser, radio waves or other methods, anti-inflammatory suppositories should be placed 5-7 days before the procedure to prevent Revitax - phytocandles, which also include. They effectively relieve inflammation and promote healing.

You can buy both expensive drugs and their cheaper counterparts. Candles with reparative properties are used 1 pc. for 10-14 days.

If necessary, tablets and other drugs are also prescribed.

With cystitis

Suffering women use different medicines in this form. Almost every thematic forum informs about this, where women often describe the means used. However, any medications for cystitis should be used after they are prescribed by medical professionals, despite the fact that they can often be bought in pharmacies without a prescription. Suppositories are prescribed as an aid in treatment. As a rule, the doctor prescribes broad-spectrum antibiotics, which are used for infectious diseases.

Most often, with cystitis, suppositories are prescribed. Hexicon (the composition includes chlorhexidine, which is an antiseptic), Betadine , Genferon , Macmirror , Synthomycin suppositories , Candles with Palin and etc.

conclusions

In modern medicine there is a large number of drugs in this form. Their use allows you to quickly and efficiently cure various diseases of the female reproductive system. A number of the drugs described above are also used for menopause. But every woman should understand that the most effective and fastest treatment will be if, after establishing a diagnosis, a gynecologist prescribes a treatment regimen.

Name:

Metronidazole (Metronidazolum)

Pharmacological
action:

Antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole.
Mechanism of action consists in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microorganism cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against:
- Trichomonas vaginalis,
- Entamoeba histolytica,
- Gardnerella vaginalis,
- Giardia intestinalis,
- Lamblia spp.
- as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some Gram-positive microorganisms (Eubacter spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.).
IPC for these strains is 0.125-6.25 µg/ml.
In combination with amoxicillin is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole). Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against ordinary aerobes. Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, stimulates reparative processes.

Indications for
application:

Protozoal infections: extraintestinal amoebiasis, including amoebic liver abscess, intestinal amoebiasis (amebic dysentery), trichomoniasis, giardiasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomonas urethritis.
Infections caused by Bacteroides spp.. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): bone and joint infections, CNS infections, incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis.
Infections caused by Clostridium spp.., Peptococcus and Peptostreptococcus: infections of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal fornix).
Pseudomembranous colitis(associated with the use of antibiotics). Gastritis or duodenal ulcer associated with Helicobacter pylori.
Prevention of postoperative complications(especially interventions on the colon, perirectal area, appendectomy, gynecological operations).
Radiation therapy of patients with tumors- as a radiosensitizing drug in cases where tumor resistance is due to hypoxia in tumor cells.

Mode of application:

Powder for solution for intravenous administration, solution for infusion, suspension for oral administration, tablets, vaginal tablets, coated tablets:

Inside and parenterally. Inside, during or after a meal (or squeezed milk), without chewing.
With trichomoniasis- 250 mg 2 times a day for 10 days or 400 mg 2 times a day for 5-8 days. Women need to additionally prescribe metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g / day. Between courses, you should take a break of 3-4 weeks with repeated control laboratory tests. Alternative scheme therapy is the appointment of 2 g once to the patient and his sexual partner.
Children 2-5 years old- 250 mg / day; 5-10 years old - 250-375 mg / day, over 10 years old - 500 mg / day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.
With giardiasis- 500 mg 2 times a day for 5-7 days. Children under 1 year old- 125 mg / day, 2-4 years - 250 mg / day, 5-8 years - 375 mg / day, over 8 years - 500 mg / day (in 2 divided doses). The course of treatment is 5 days.
With giardiasis- 15 mg/kg/day in 3 divided doses for 5 days. Adults: with asymptomatic amoebiasis (if a cyst is detected), the daily dose is 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.
For chronic amoebiasis daily dose - 1.5 g in 3 doses for 5-10 days, with acute amoebic dysentery - 2.25 g in 3 doses until the symptoms stop.
For liver abscess the maximum daily dose is 2.5 g in 1 or 2-3 doses, for 3-5 days, in combination with antibiotics (tetracyclines) and other methods of therapy. Children 1-3 years old- 1/4 dose of an adult, 3-7 years- 1/3 adult dose, 7-10 years old - 1/2 adult dose.
With balantidiasis- 750 mg 3 times a day for 5-6 days. With ulcerative stomatitis, adults are prescribed 500 mg 2 times a day for 3-5 days; in this case, the drug is not indicated for children.
For pseudomembranous colitis- 500 mg 3-4 times a day. For the eradication of Helicobacter pylori - 500 mg 3 times a day for 7 days (as part of combination therapy, for example, a combination with amoxicillin 2.25 g / day).
In the treatment of anaerobic infections the maximum daily dose is 1.5-2 g.
In the treatment of chronic alcoholism appoint 500 mg / day for a period of up to 6 (no more) months.
For the prevention of infectious complications - 750-1500 mg / day in 3 doses 3-4 days before surgery or once 1 g on the first day after surgery. 1-2 days after the operation (when ingestion is already allowed) - 750 mg / day for 7 days.
With severe renal dysfunction(CC less than 10 ml / min) the daily dose should be reduced by 2 times. Suspension for oral administration.
Anaerobic bacterial infections: children - 7 mg / kg every 8 hours, course of treatment - 7-10 days;
giardiasis: children 2-5 years old - 200 mg / day, 5-10 years old - 300 mg / day, 10-15 years old - 400 mg / day. The duration of treatment for giardiasis is 5 days. The course of treatment can be repeated after 10-15 days Parenterally. Adults and children over 12 years of age at an initial dose of 0.5-1 g intravenously drip (duration of infusion - 30-40 minutes), and then every 8 hours, 500 mg at a rate of 5 ml / min. With good tolerance, after the first 2-3 infusions, they switch to jet administration. The course of treatment is 7 days. If necessary, IV administration is continued for a longer time. The maximum daily dose is 4 g. According to the indications, a transition is made to a maintenance intake at a dose of 400 mg 3 times a day. Children under the age of 12 are prescribed according to the same scheme in a single dose - 7.5 mg / kg.
With purulent-septic diseases usually spend 1 course of treatment. For prophylactic purposes, adults and children over 12 years of age are prescribed 0.5-1 g intravenously on the eve of surgery, on the day of surgery and the next day - 1.5 g / day (500 mg every 8 hours). After 1-2 days, they switch to maintenance therapy inside. For patients with chronic renal failure and CC less than 30 ml / min and / or liver failure, the maximum daily dose is not more than 1 g, the frequency of administration is 2 times a day.
As a radiosensitizing drug injected intravenously at the rate of 160 mg/kg or 4-6 g/sq.m of body surface 0.5-1 hour before the start of irradiation. Apply before each irradiation session for 1-2 weeks. In the remaining period of radiation treatment, metronidazole is not used. The maximum single dose should not exceed 10 g;
For cancer of the cervix and body of the uterus, skin cancer is used in the form of local applications (3 g is dissolved in a 10% DMSO solution), swabs are moistened, which are applied topically, 1.5-2 hours before irradiation).
In case of poor regression of the tumor, applications carried out during the entire course of radiation therapy. With positive dynamics of tumor clearance from necrosis - during the first 2 weeks of treatment.

Vaginal gel, vaginal suppositories, vaginal tablets:
Intravaginally, once 2 g or as a course of treatment 500 mg / day 2 times a day (morning and evening) for 10 days. During the course of treatment, sexual intercourse should be avoided.

Gel for external use, cream for external use:
Apply to pre-cleansed skin with a thin layer 2 times a day, morning and evening, for 3-9 weeks. If necessary, apply an occlusive dressing. Application of cream and gel can be alternated. The average duration of treatment is 3-4 months, the therapeutic effect is usually noted after 3 weeks of treatment.

Side effects:

From the digestive tract: diarrhea, loss of appetite, nausea, vomiting, intestinal colic, constipation, unpleasant "metallic" taste and dry mouth, glossitis, stomatitis, pancreatitis.

From the nervous system and sensory organs: headache, dizziness, impaired coordination of movements, syncope, ataxia, confusion, irritability, depression, irritability, weakness, insomnia, hallucinations; with long-term therapy in high doses - peripheral neuropathy, transient epileptiform seizures.

From the genitourinary system: dysuria, cystitis, polyuria, urinary incontinence.

allergic reactions: urticaria, skin rash, skin hyperemia, nasal congestion, fever.

Other: arthralgia, flattening of the T wave on the ECG; with long-term therapy in high doses - leukopenia, candidiasis.

Local reactions: with a / in the introduction - thrombophlebitis (pain, hyperemia or swelling at the injection site). With intravaginal use - itching, burning, pain and irritation in the vagina; thick, white, mucous discharge from the vagina, odorless or with a slight odor, frequent urination; after discontinuation of the drug, the development of vaginal candidiasis is possible; burning sensation or irritation of the penis in the sexual partner. When applied externally - hyperemia, peeling and burning of the skin, lacrimation (if the gel is applied close to the eyes).

Contraindications:

Hypersensitivity, leukopenia(including in history), organic lesions of the central nervous system (including epilepsy), liver failure (in the case of high doses), pregnancy (I trimester), lactation. With caution. Pregnancy (II-III trimesters), renal/liver failure.

Interaction
other medicinal
by other means:

Enhances the effect of indirect anticoagulants, which leads to an increase in the time of formation of prothrombin. Similar to disulfiram causes intolerance ethanol. Simultaneous use with disulfiram can lead to the development of various neurological symptoms (the interval between administration is at least 2 weeks). Metronidazole for intravenous administration is not recommended to be mixed with other drugs. Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood serum and an increase in the risk of side effects. The simultaneous administration of drugs that stimulate microsomal oxidation enzymes in the liver (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, resulting in a decrease in its plasma concentration. When taken simultaneously with Li + preparations, the concentration of the latter in plasma and the development of symptoms of intoxication may increase. It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamides enhance the antimicrobial effect of metronidazole.

Cream for outdoor use
- vaginal gel,
- vaginal suppositories,
- vaginal tablets,
- powder for solution for intravenous administration,
- solution for infusion,
- suspension for oral administration,
- pills,
- coated tablets.

Storage conditions:

List B. In a dark place.

1-(b-hydroxyethyl)-2-methyl-5-nitroimidazole.
Metronidazole is a white or slightly greenish crystalline powder. Slightly soluble in water, difficult - in alcohol.
Pills contain 0.25 and 0.5 g of metronidazole.
Vaginal suppositories contain 0.5 g of metronidazole.
100 ml solution contain:
metronidazole - 0.5 g;
Excipients: sodium chloride, disodium salt of ethylenediaminetetraacetic acid, water for injection.

As you know, the vaginal microflora in a woman consists of lactobacilli. As a result of a disease such as bacterial vaginitis, the number of these lactobacilli is significantly reduced, which leads to a violation of the normal internal environment of the vagina.

Scientists have proven that metronidazole suppositories are better and more effective than using gels. For a quick recovery, it is recommended to use not only metronidazole suppositories, but also nystatin ones. Candles with metronidazole and nystatin are used for 7-10 days.

Interesting! Candles are more effective than gels due to the fact that they contain a larger amount of active ingredient.

Indications for use

Metronidazole suppositories, instructions for use of which are provided below, are considered a broad-spectrum agent. It is necessary to use this medicine if the following diseases exist:

• giardiasis;
• inflammation of the inner heart membrane;
• amoebiasis;
• accumulation of purulent secretions in the organs;
• thrush;
• chronic alcoholism;
• liver abscess;
• diseases of the genitourinary system due to various infections;
• sepsis and peritonitis.

This drug can also be used as a prophylaxis before a complex manipulation in gynecology or before a certain surgical intervention.

The gel is also very popular in the treatment of infectious diseases. With inflammation, infections in the oral cavity and with various dental procedures, metrogil gel is an effective remedy. In addition, an ointment with the active substance metronidazole is recommended for use by those people who have skin problems. It helps with breakouts on the face.

Metronidazole suppositories are very popular in gynecology. One suppository of the drug contains 500 mg of the active ingredient. This medication is used to treat such pathologies as:

• urethritis;
• vaginitis;
• urogenital trichomoniasis.

Interesting! According to the feedback of the patients, after two days a positive result is seen from the treatment with metronidazole suppositories.

What is the drug

The composition of the active ingredient in the preparation is of two types: 500 mg and 250 mg of the active substance Metronidazole. In appearance, the suppository resembles the shape of a rocket with a rounded end. The color of the substance is more like white or white with a yellowish tint.

When using the drug, the pharmacokinetics is that only a small part of the drug is absorbed into the body (within 20%). When using tablets, this figure is higher. Metronidazole is excreted from the body within eleven hours through urine and feces.

Metronidazole suppositories, instructions for use

The course of treatment with the drug ranges from one week to ten days. One suppository is inserted into the vagina at bedtime in case of bacterial vaginosis. If the patient is being treated for trichomonas vaginitis, then suppositories are used twice a day - in the morning and in the evening. The course of treatment is recommended to be repeated after a month and a half.

Important! To obtain a stronger effect, it is recommended to use metronidazole tablets together with suppositories.

Use scissors to cut open the package and remove the suppository. Then, with clean hands, gently insert the suppository deep into the vagina. Treatment should be started at the beginning of the menstrual cycle for greater effect.

In addition, during the period of treatment it is not recommended to use an additional method of self-treatment in the form of douching with various solutions or preparations. And in order for the treatment to give a positive result, during the use of medications, doctors do not recommend sexual intercourse.

If a liver abscess is found in a patient, then the dosage and method of using the drug are different from the previous ones. In this case, it is recommended to consume 2.5 g per day for five days. In the treatment of chronic alcoholism, the drug is prescribed according to the following principle:

• a suppository is used twice a day (one suppository in the morning and one in the evening);
• chronic alcoholism is treated with this medication for six months;
• if during treatment there are problems with the normal functioning of the kidneys, then the dosage of the drug is reduced. In this case, it is recommended to use one candle per day (preferably at night).

Can metronidazole be used during menstruation or rectally? Treatment of infectious diseases is thus not rational and useless. Metronidazole during menstruation does not affect the infection at all.

Since the drug can cross the placenta, it is not recommended for use during pregnancy. Only in extreme cases is it prescribed in the third trimester of pregnancy. In addition, metronidazole passes into breast milk, so the use of this drug during breastfeeding is prohibited. In the case of treatment with metronidazole, breastfeeding should be discontinued.

Side effects of the drug

Since metronidazole suppositories are considered to be of synthetic origin, before using them, you must familiarize yourself with the full list of contraindications and side effects. Therefore, before starting treatment, it is recommended to consult with a specialized doctor.

For example, metronidazole can have an adverse reaction on the digestive system. In this case, the patient may feel nauseous and may vomit even after a single use of the drug. If the patient does not tolerate the drug, then he may experience severe pain and spasms in the intestinal area, as well as constipation or diarrhea.

Adverse reactions to the drug that may occur as a result of its use:

• an allergic reaction in the form of a rash, itching and redness of the skin;
• urine may change to a brownish-reddish color;
• headaches and dizziness;
• convulsions;
• there are rare cases of neutropenia or pancytopenia;
• encephalopathy;
• rare cases of hallucinations and mental disorders;
• myopia;
• diplopia.

Contraindications to the drug

There are certain contraindications to the use of such a drug as metronidazole suppositories. The main ones are:

• organic negative influences of the nervous system;
• blood disease;
• the beginning of pregnancy (first trimester);
• hypersensitivity to the active substance;
• improper functioning of the liver;
• renal and hepatic insufficiency (permitted only under medical supervision and with extreme caution).

Important! The dosage is prescribed by the doctor for each patient individually. Changing it on your own can lead to negative consequences!

Analogues of the drug Metronidazole

The modern pharmacological industry has developed several analogues of metronidazole, the composition of which practically does not differ from the original. Metronidazole suppositories, as well as analogues, have their own side effects. The main analogues include:

• Trikhapol;
• Metromicon-Neo;
• Nicamed;
• Metrophyte;
• Miconazole;
• Clean;
• Metrogyl;
• Flagin.

If the doctor prescribes analogs of a weaker effect, then he recommends taking iodoxide as a supplement. But for reinsurance, iodoxide is prescribed by a specialized doctor when taking metronidazole and its strong analogues. After all, iodoxide is an antimicrobial drug that effectively destroys fungus or microbes in the body.

How much does such a drug cost? The drug Metronidazole costs an average of 200 rubles. But you can find its analogues with a similar composition and indications, but at a lower price.

But it is not recommended to make a decision about the purchase of analogues on your own. After all, any medicinal substance that includes metronidazole in its composition is synthetic, therefore it can cause a different allergic reaction. Therefore, before buying, you should consult with a specialized doctor who will select the most effective and safe drug.

Any infectious inflammation of the genital tract should be treated promptly. One of the effective remedies for such problems is Metronidazole suppositories. Their active substance of the same name has a broad antibacterial and antimicrobial effect, which allows you to get rid of most pathogenic microorganisms. Metronidazole disrupts the metabolism of cells that cause vaginal infections, which causes their death.

Application in gynecology

Women are most susceptible to genital tract infections, because not only sexual intercourse, but also various medical interventions can become a source of infection. And the need for a speedy recovery in the beautiful half is much higher. In order to prevent the risk of complications up to infertility, you need to follow all the recommendations of your doctor and follow the prescribed treatment regimen with Metronidazole. Instructions for use of the drug contain recommended doses, but it is the doctor who adjusts the treatment according to the tests and the nature of the course of the disease.

Metronidazole is available in various forms, but in gynecology the most popular agents that act locally are suppositories and creams. Each suppository contains 125, 250 or 500 mg of the active ingredient and auxiliary components (semi-synthetic glycerides, solid fat, etc.).

Metronidazole suppositories inhibit Trichomonas, gram-negative anaerobes and anaerobic streptococcus, some gram-positive bacteria, Candida fungus.

• urogenital form of trichomoniasis;
• urethritis of varying severity;
• thrush;
• vaginitis, including nonspecific;
• nonspecific bacterial vaginosis.

More than 300 pharmaceutical companies around the world produce metronidazole. In Russia, it is included in the list of vital and essential medicines subject to price restrictions. Therefore, the medicine is quite affordable, which is especially important for people with a small family budget.

Method of treatment

The drug in the form of suppositories is injected deep into the vagina. Its advantage over metronidazole tablets is its rapid local action. This form is the safest: the medicine does not enter the bloodstream. After the introduction, it is recommended to take a supine position for 30-60 minutes.

Already after the first use of candles, a pronounced effect appears. The course is 7-10 days, but the exact period is set by the gynecologist.

When treating with metronidazole in gynecology, the use of alcohol is completely excluded. This is due to the fact that the interaction of metronidazole and alcohol can lead to an antabuse-like effect, when symptoms of alcohol poisoning develop rapidly. During therapy, sexual activity is also excluded.

Both sexual partners should be treated to prevent re-infection.

Treatment should not be interrupted if it seemed that the visible symptoms had disappeared and the desired result had been achieved. In this case, symptoms of vaginal candidiasis may appear.

After the course of therapy, you need to re-take tests. Only in the case of a positive result can we talk about a complete recovery.

Side effects

Metronidazole suppositories are extremely rare, but side effects may still be present:

• skin rashes of an allergic nature and urticaria;
• itching and burning on the mucous membranes;
• pain in the vulva;
• frequent urination;
• migraine, dizziness, insomnia;
• change in taste, metallic taste in the mouth;
• nausea, vomiting, loss of appetite;
• bowel disorders (diarrhea, constipation);
• spasms of the intestines;
• blood diseases in which the level of leukocytes is low.

If these side effects appear, they should be reported to the attending physician. That, in turn, can change the drug to another. Do not change medications on your own.

Instructions for use provides a complete list of contraindications, including individual intolerance to the drug, epilepsy, problems with the central nervous system, serious kidney and liver diseases, reduced levels of leukocytes in the blood, the first trimester of pregnancy and lactation. In the second and third trimester, the use of metronidazole is strictly adjusted by the doctor and is carried out under his supervision.

Judging by the reviews of women who used vaginal suppositories, Metronidazole is very effective in the treatment of sensitive infections of the genital tract.

After a few days of application, the discharge and itching stop, and the full course of complex therapy completely cures the disease, even if it occurs in severe form.

Metronidazole suppositories - an antimicrobial and antiprotozoal agent with an antibacterial effect, is of synthetic (artificial) origin, and belongs to the group of drugs that are derivatives of nitromidazole.

The drug is used for invaginal administration, and is available in the form of suppositories in two concentrations of a potent basic substance: 250 mg (in a package of 10 suppositories) and 500 mg (in a package of 10 suppositories). Each candle is packed in a contour cassette, in appearance it has an elongated shape, white or slightly yellowish.

It is necessary to understand what are the indications for use in gynecology, and what use do suppositories suggest? And also consider similar drugs based on metronidazole, and study the reviews of doctors on this drug.

Composition, indications for use

Candles with metronidazole, in addition to the active substance, additionally contain polyethylene oxide (1500) and polyethylene oxide (400). The drug shows high activity in the treatment of gardnerellosis, trichomoniasis and other diseases.

Due to topical application, bacteria (gram-positive, as well as overwhelmingly anaerobic), fungi (including those that provoke a disease such as candidiasis) die. When using the agent, the susceptibility of some neoplasms in the human body to radiation increases, and the processes of a reparative nature are stimulated.

With the introduction of suppositories, a potent element can be absorbed only by a small part. A pronounced local effect is revealed. Only a small concentration of the injected agent can be detected in the patient's blood.

Part of the drug is transformed into metabolites, which are excreted through the liver and kidneys. The maximum content of the drug in the body is observed five hours after the use of the drug.

Instructions for use presents the following situations when it is advisable to prescribe this drug:

With gynecological surgical interventions, Metronidazole suppositories can be prescribed as a preventive measure to prevent infectious pathologies.

It is worth noting that the drug is produced by more than 300 pharmacological companies. On the territory of Russia, the drug is included in the list of essential drugs, and it has a limited price.

Therefore, every person can buy a medicine, and this will not require excessive financial investments.

Contraindications and side effects

Having learned what this drug is for, it is necessary to consider in what situations it is not recommended, as well as to find out the likely adverse reactions from the use of the drug.

It is known that any medication has its own contraindications, and candles are no exception to this rule. Contraindications are taken into account without fail before prescribing a local medicine.

The doctors' comments show that the active component of the drug can penetrate the placental barrier, respectively, to the child, so they try not to prescribe it during pregnancy. However, it may be recommended after the 3rd month of pregnancy if the life of the mother is in danger.

When a medicine is prescribed during lactation, it is recommended that a woman stop breastfeeding for the period of therapy. Studies have shown that the drug is able to pass into breast milk.

The following situations are also contraindications for use:

1. Hypersensitivity to the agent or its auxiliary components.
2. Violation of the functionality of the liver.
3. Diseases of the circulatory system (for example, leukopenia).
4. Organic disorder of the central nervous system.

With extreme caution and under the supervision of the attending doctor, suppositories are prescribed for liver and kidney failure.

It is necessary to use candles only in the dosage recommended by the doctor. With an independent decrease in the dose or frequency of administration, the medicine will not give the required therapeutic effect, and with an increase, an overdose is observed.

Possible adverse reactions to the topical drug:

• Neutropenia.
• Allergic reactions with skin manifestations (redness and peeling of the skin, itching, burning). Anaphylactic shock and pustular satiety (very rare).
• Headaches, dizziness, disorders of the musculoskeletal system, convulsive state, tremor of the limbs.
• Mental disorders.
• Violation of the functionality of the liver, jaundice.
• Changes in the quality of the liver.
• Changing the color of urine up to a dark brown hue.

If suppositories are used for too long a period of time, then the development of fungi in the vagina is not excluded, which in turn requires the appointment of an antifungal agent for treatment.

When the patient took the prescribed drug, not following the recommendations of the doctor, an overdose of the drug is detected, characterized by increased side effects. In this case, symptomatic treatment and supportive therapy are prescribed.

Instructions for using candles

When the drug is prescribed during pregnancy or lactation, the dosage of the drug is adjusted by about a third of the traditional dose. And only if the therapeutic effect is insufficient and according to direct indications, the doctor can increase it.

During treatment, it is necessary to abandon the use of alcoholic beverages, since ethanol increases the risk of side effects - nausea, vomiting, disruption of the gastrointestinal and digestive tract. In addition, during the period of therapy, it is desirable to give up driving and vehicles.

On Metronidazole suppositories, the instruction is as follows:

1. As a rule, one candle is prescribed immediately before bedtime.
2. The duration of therapy is one and a half weeks.
3. If the therapeutic effect is insufficient, the course of treatment can be repeated after one or one and a half months.
4. Before the introduction of candles, intimate hygiene procedures are performed, suppositories are introduced in the supine position.
5. In a severe form of the disease, the doctor may recommend a combination of suppositories and tablets with metronidazole.

If for any reason the patient cannot carry out treatment immediately before bedtime, then the introduction of suppositories during the daytime requires being in a horizontal position for at least one hour.

It should be noted that if sulfonamides are taken simultaneously with Metronidazole, then the antimicrobial effect is enhanced. Metronidazole is not compatible with Disulfiram, such a symbiosis leads to symptoms of damage to the central nervous system.

Many patients are concerned about the question, how much does the remedy cost? As mentioned above, everyone can afford the drug, and the price of Metronidazole suppositories is from 70 to 90 rubles.

Candle analogs

To date, the pharmaceutical industry provides the following similar products in the form of suppositories, which are direct analogues of Metronidazole - Trichopolum, Ginalgin, Flagil.

Suppositories are widely used in gynecological practice, are prescribed for the treatment of fungal and bacterial infections of the genital organs and vagina, and can be recommended for mixed infectious diseases.

How to use Metromicon-Neo suppositories correctly:

• Before the introduction of the candle, hygiene procedures are carried out, hands are processed.
• The candle is inserted deep into the vagina.
• Usually one suppository per day is prescribed.
• The duration of therapy depends on the disease, and the severity of the clinical picture of the pathology.

Absolute contraindications are the first three months of pregnancy, the period of breastfeeding, the virginity of the patient, and before the age of 18, the use is also prohibited.

With special care, it is prescribed for blood diseases, diabetes mellitus, impaired blood circulation, pathologies of the central nervous system, impaired functionality of the liver and kidneys. The price of the tool varies from 350 to 400 rubles.

Features of the use of Trichopol candles:

1. The duration of therapy is 10 days, one candle is administered per day.
2. The course of treatment begins immediately after the end of the menstrual cycle.

Candles can provoke burning of the vaginal mucosa. The drug is not prescribed in the first trimester of pregnancy, during lactation. The cost of funds in the range of 300-350 rubles.

Suppositories Ginalgin have an antibacterial, antifungal, antiprotozoal and bactericidal effect, have a wide spectrum of action. Assign one candle per day, the duration of therapy is 7-10 days.

Ginalgin is not recommended for intolerance to the drug, as well as for the following pathologies in history: organic disorders of the central nervous system, blood diseases, disorders of the musculoskeletal system, pregnancy and lactation. The cost is 300-310 rubles.

Flagyl is a medicinal preparation with antibacterial and antiprotozoal action. One suppository contains 500 mg of metronidazole and fat. Usually, one suppository is prescribed per day; in case of liver failure, suppositories can be recommended every other day. The price is 800-900 rubles.

As the review shows, Metronidazole in the form of suppositories, as well as its analogues, have their own indications and side effects, and in some situations their use even poses a health hazard. Therefore, before using suppositories, it is advisable to consult a doctor.

The doctor will talk about the properties of Metronidazole suppositories and its analogues in the video in this article.