Characteristics and beneficial properties of vitamin B6 (pyridoxine) - is it possible to reduce the effect of contraceptives? Pyridoxine: what kind of vitamin, biological role, signs of deficiency and indications for the use of pyridoxine hydrochloride.

Pyridoxine hydrochloride (pyridoxine)

Composition and form of release of the drug

50 pcs. - polymer containers (1) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (10) - packs of cardboard.
10 pieces. - polymer containers (1) - packs of cardboard.
20 pcs. - polymer containers (1) - packs of cardboard.
30 pcs. - polymer containers (1) - packs of cardboard.
40 pcs. - polymer containers (1) - packs of cardboard.
100 pieces. - polymer containers (1) - packs of cardboard.
50 pcs. - cellular contour packings (1) - packs of cardboard.
50 pcs. - cellular contour packings (2) - packs of cardboard.
50 pcs. - cellular contour packings (3) - packs of cardboard.
50 pcs. - cellular contour packings (4) - packs of cardboard.
50 pcs. - cellular contour packings (5) - packs of cardboard.
50 pcs. - cellular contour packings (10) - packs of cardboard.

pharmachologic effect

With simultaneous use, it potentiates the action of diuretics.

With simultaneous use with levodopa, the effects of levodopa are reduced or completely inhibited.

With simultaneous use with isonicotinhydrazide, penicillamine, cycloserine, a decrease in the effectiveness of pyridoxine is possible.

With simultaneous use with phenytoin, a decrease in plasma concentrations of phenytoin and phenobarbital is possible.

special instructions

Use with caution in gastric ulcer and duodenal ulcer, coronary artery disease.

Pregnancy and lactation

For impaired liver function

In severe liver damage, pyridoxine in high doses can cause a deterioration in its function.

1438 readers

The material is for informational purposes only. For accurate information, contact a specialist.

Pyridoxine (Pyridoxinum) is a substance involved in all cellular processes. The enzyme is produced in the intestinal microflora and can enter the body from the outside, as it is found in many products of animal and vegetable origin. In this section, we will take a closer look at what pyridoxine is, what kind of vitamin it is, and what its main functions are.

Pyridoxine: what kind of vitamin is it

Pyridoxine is known as vitamin B6. Its chemical formula is C8H11NO3. This water-soluble, odorless substance is presented in the form of colorless crystals with a sour-bitter taste.

Vitamin is able to dissolve in alcohol and water, but it is resistant to esters and fatty compounds. It does not respond to heat and oxygen, but is rapidly destroyed by light.

There are many synthetic analogues of this substance, the most popular of which is pyridoxine hydrochloride. It is available in tablets and ampoules for injection.

daily requirement

The daily amount of vitamin B6 necessary for the normal functioning of the body depends on the sex and age of the patient. Detailed information is given in the tables.

Children

Men

Women

There are a number of cases where a person needs an increased dose of vitamin B6.

This happens under the following conditions:

• stress and depression;
• increased physical activity;
• long stay in the cold;
• smoking and alcohol abuse;
• the presence of hepatitis, radiation sickness, intestinal infections and HIV;
• the period of pregnancy and breastfeeding;
• taking oral contraceptives.

In these cases, the dosage is calculated by the attending physician individually.

Biological role for the body

Pyridoxine is necessary for the normal course of the following processes in the body:

• metabolism;
• lipid and carbohydrate metabolism;
• production and conversion of amino acids;
• stabilization of the nervous system;
• normalization of glucose and hemoglobin levels in the blood;
• cell regeneration.

On a note. Pyridoxine is a wonderful vitamin for hair. It is often added to cosmetic masks and remedies. This substance allows you to strengthen the bulbs, stimulates hair growth and fights hair loss, and also prevents dandruff.

Vitamin Deficiency Signs

There are a number of common symptoms indicating vitamin B6 deficiency.

These include the following manifestations:

• sleep disorders;
• increased excitability or slow reactions;
• apathy and depression;
• causeless anxiety;
• convulsive attacks and numbness of the limbs;
• decrease in body resistance;
• hair loss;
• muscle weakness;
• frequent conjunctivitis;
• nausea;
• loss of appetite;
• increased gas formation in the intestines;
• inflammation of the mucous membranes in the mouth;
• dry skin and other dermatological problems.

In children, hypovitaminosis against the background of a lack of vitamin B6 is manifested by the following symptoms:

• frequent convulsions resembling an epileptic seizure;
• excitability and tearfulness;
• malfunctions in the work of digestion;
• diathesis and allergic reactions;
• growth retardation and developmental delays.

Attention! Since these symptoms can be accompanied by a number of other diseases, if such problems appear, a comprehensive examination should be performed.

Indications for the use of pyridoxine hydrochloride

Since pyridoxine is involved in almost all processes occurring in the human body, it is prescribed for violations of various organs and systems.

Conditions where vitamin B6 supplementation is necessary include:

• toxicosis during pregnancy;
• premenstrual syndrome;
• emotional disorders;
• neurological problems;
• diseases of the liver, heart and blood vessels;
• violations of the functions of the vestibular apparatus;
• allergy;
• dermatological problems;
• dandruff, brittleness and hair loss;
• radiation sickness;
• diabetes;
• diseases of the musculoskeletal system;
• other problems associated with overweight.

Attention! It is possible to use pyridoxine in ampoules or tablets only as directed by a doctor, and in the presence of ulcerative lesions of the stomach or intestines, therapy should be carried out under strict medical supervision.

Compatibility with other substances

When taking vitamin B6, it is important to consider how it combines with other micronutrients and drugs.

Pyridoxine is necessary for the absorption of vitamin B12 and magnesium, for this reason, their combined use is recommended. But if the substance is injected in combination with B12 and B1 in the same syringe, these vitamins cancel each other out.

Medicines that can weaken the effect of vitamin B6 include the following groups of medicines:

• contraceptives;
• barbiturates;
• antibiotics;
• narcotic substances;
• antituberculous, anticonvulsant, antiasthmatic, diuretic and antiepileptic drugs.

Pyridoxine reduces the effectiveness of drugs used in Parkinson's disease and enhances the effect of diuretics.

Where is vitamin B6 found

Vitamin B6 can be obtained from food.

It is found in the following animal products:

• chicken and pork liver;
• sour cream;
• marine fish (especially pink salmon and Atlantic herring);
• beef;
• egg yolks;
• hard cheeses;
• cottage cheese.

Herbal products that can compensate for the lack of pyridoxine include:

• wheat flour;
• sunflower seeds;
• wheat bran;
• garlic;
• walnuts, hazelnuts and peanuts;
• corn, barley and millet;
• buckwheat;
• peas;
• potatoes;
• White mushrooms;
• zucchini;
• grape;
• apricots;
• apples.

When planning meals, you should be aware that vitamin B6 normalizes cellular processes and benefits the body only if it is used in moderation. Oversaturation is as dangerous as deficiency.

Related videos

Pyridoxine: what kind of vitamin, biological role, signs of deficiency and indications for the use of pyridoxine hydrochloride

Pyridoxine is a vitamin B6 that is involved in the metabolic processes of the human body. This substance is not a drug. Vitamin deficiency in the body (hypovitaminosis) negatively affects the immune system and affects the functions of internal organs.

Pyridoxine is a vitamin B6 that is involved in the metabolic processes of the human body.

International non-proprietary name

The international name for this drug is Pyridoxine.

Atx and registration number

Registration number of pyridoxine in the anatomical-therapeutic-chemical classification A11HA02.

Pharmacotherapeutic group

This remedy is a vitamin.

Pharmacological properties

Pharmacodynamics

Pyridoxine plays the following role in humans:

1. It ensures the normal functioning of the nervous system and maintains optimal blood sugar levels. This substance, like riboflavin, improves brain function (uplifts mood and improves memory). With insufficient intake of pyridoxine, convulsions are possible.
2. Participates in the metabolism of amino acids. Vitamin is an active coenzyme and is involved in decarboxylation processes.
3. Normalizes fat metabolism.
4. Helps lower blood cholesterol levels, which is important in atherosclerosis.
5. Normalizes the work of the liver.
6. Participates in erythropoiesis (formation of red blood cells).
7. Promotes the formation of nucleic acids.
8. Eliminates muscle spasm.
9. Reduces the need for insulin in diabetic patients.
10. Has a diuretic effect.
11. It has a beneficial effect on the skin, increasing its ability to regenerate.

EKMed - Vitamin B6 (Pyridoxine)

Vitamin B6 pyridoxine

Benefits of Vitamin B6 (Pyridoxine)

Pharmacokinetics

Metabolism (conversion of the vitamin) occurs in the tissues of the liver. Pyridoxaminophosphate and pyridoxal phosphate are formed there. B6 is deposited in muscle tissue, liver and central nervous system (brain and spinal cord). A feature of the drug is the ability to penetrate the hematoplacental barrier and enter breast milk. When taking the vitamin in the form of tablets, pyridoxine is excreted mainly by the kidneys. With intravenous administration, part of the substance is excreted in the bile.

daily requirement

The amount of vitamin intake depends on age and load. The norm is from 0.4 mg (for newborns) to 2.4 mg (for the elderly). The average daily requirement for an adult is 1.5 mg. In pregnant women, the rate is slightly higher.

What is vitamin b6 for?

Help in the fight against excess weight

Pyridoxine tablets are often used for weight loss purposes. It is effective for obesity. Vitamin B6 promotes the breakdown of fats and optimal energy expenditure. An important role in the process of losing weight is played by the improvement of carbohydrate metabolism. For greater effect, vitamin intake is recommended to be combined with exercise.

When Reception Is Essential

The indication for the appointment of pyridoxine hydrochloride is a clinically pronounced deficiency in the body of this vitamin. This condition is characterized by the following symptoms:

• inability to remember a large amount of information;
• forgetfulness;
• dyspepsia in the form of decreased appetite and nausea;
• drowsiness;
• damage to the extrapyramidal system;
• irritability;
• sleep disturbance;
• dry skin;
• excessive hair loss on the head;
• the presence of cracks in the corners of the mouth;
• symptoms of lesions of the oral mucosa;
• eye damage by the type of conjunctivitis (manifested by lacrimation, redness and itching);
• depressed mood;
• decrease in performance.

Other possible indications are psoriasis, toxemia during childbearing, neurodermatitis, eczema, sideroblastic form of anemia, allergic dermatitis, atherosclerotic vascular disease, diabetes mellitus, exudative diathesis, herpes zoster, low white blood cell count, motion sickness and pathology of the nervous system.

Where is contained

The following foods are rich in pyridoxine:

• yeast;
• milk;
• pistachios;
• hazelnut;
• beans;
• raisin;
• walnuts;
• sauces based on tomatoes;
• cereals (barley, millet, barley, semolina, rice, buckwheat);
• egg yolks;
• fish (halibut, tuna, mackerel);
• fruits (bananas, tangerines, grapes, melons, lemons, pomegranates and oranges);
• vegetables (cabbage, tomatoes, carrots, avocados, rutabagas, potatoes, sweet peppers);
• meat (rabbit, beef, chicken, lamb);
• germinated grain;
• offal (beef liver, pork kidneys, heart).

Vitamin B6 in foods

WHAT IS VITAMIN B6 DEFICIENCY DANGEROUS. WHAT PRODUCTS CONTAIN

With a lack of these products in the diet or malabsorption of pyridoxine, hypovitaminosis develops.

Composition and form of release of pharmaceutical preparations

Preparations based on pyridoxine hydrochloride are available in the form of tablets, dragees and a solution for injection. The most popular drugs are Kombilipen, Milgamma, Trigamma, Pyridoxine-Vial, Pyridoxine Bufus, Vitagamma and Binavit. Most often, the composition of the tablets and the solution includes several vitamins at once. The main component of the tablets is vitamin B6. They are packed in a jar in the amount of 50 pcs. The solution for injection is packaged in ampoules of 1 ml, 10 pcs. in every package. The amount of active substance is 2.5 or 10 mg.

Pyridoxine hydrochloride contraindications

Injections and pills are not prescribed for hypersensitive people. Pyridoxine should be taken with caution in case of severe liver damage against the background of chronic hepatitis, duodenal ulcer and stomach ulcer, as well as coronary heart disease.

Method of application and dosage

Preparations based on vitamin B6 are consumed regardless of the meal.

Pills

With an acute shortage of pyridoxine, tablets should be taken 4 times a day, 80 mg each.

Ampoules

With injection (intramuscular or subcutaneous) administration of the drug, the daily dosage is 50-100 mg.

Special instructions for the use of pyridoxine hydrochloride

In the instructions for use of the drug there are special instructions that must be observed when taking the vitamin. In high doses, the drug can cause liver dysfunction. Complex agents (Milgamma, Kombilipen, Vitagamma) containing pyridoxine hydrochloride, thiamine and cyanocobalamin should not be administered to patients under 18 years of age.

During pregnancy and lactation

During the bearing of a child, drugs with pyridoxine, like folic acid tablets, are prescribed according to strict indications in the right dosage.

In childhood

Children's age is not a contraindication to taking pyridoxine. Most combined drugs can only be prescribed to adults.

In old age

Vitamin can be used in old age. In this case, dose adjustment is not required.

For impaired liver function

For impaired renal function

The drug does not affect kidney function and can be used for renal pathology.

Side effects of pyridoxine hydrochloride

During treatment with vitamin B6, the following adverse reactions are possible:

• increased secretion of hydrochloric acid (dangerous with hyperacid gastritis and ulcers);
• allergic reactions in the form of urticaria, exanthema or itching;
• abdominal pain (in people with diseases of the stomach and duodenum against the background of increased acidity).

Impact on vehicle control

The drug improves the functioning of the nervous system, which favorably affects attention.

Driving a car is safe while taking vitamin B6.

Overdose

Symptoms of an overdose of pyridoxine are:

• liver dysfunction;
• changes in blood counts;
• neurological symptoms.

Hemodialysis is not required in this case. Overdose is extremely rare.

drug interaction

The action of pyridoxine is enhanced when it is taken with thiamine and other B vitamins. The concentration of pyridoxine increases when it is combined with hormonal drugs. Vitamin enhances the action of diuretics and reduces the therapeutic effect of levodopa. The drug is not recommended for use simultaneously with anti-tuberculosis drugs (Cycloserine). In the case of a combination of vitamin with phenobarbital and phenytoin, the concentration of the latter decreases.

Alcohol compatibility

Drinking alcohol while taking pyridoxine will not give the desired effect from taking the vitamin and will lead to a worsening of neurological symptoms.

Terms of dispensing from pharmacies

Preparations based on pyridoxine are sold only with a prescription.

Price

The cost largely depends on the manufacturer and composition of the drug. Complex vitamin preparations can cost about 300 rubles (Milgamma). The average price of pyridoxine in pharmacies is 50-70 rubles.

Storage conditions

When storing vitamins, the following conditions must be observed:

• the room should be cool;
• the place should be dry and protected from light;
• children should be restricted access to the drug.

Best before date

Analogues

The analogues of the drug are Pyridoxine-Vial, Pyridoxine-Bufus and Pyridoxine-Solofarm. Vitamin B6 is a component of such drugs as Protiocomb, Protub-2 (used in the treatment of tuberculosis), Protub-Lome, Protub-5, Protubpira, Compligam B, Resonizate Plus, Lyzobact, Lomecomb, Tubavit, Milgamma, Combilipen, Trigamma, MexiB6 and Cyclomycin Plus.

With a lack of vitamin b6 in the human body, fatty infiltration of the liver occurs, hypochromic anemia and many other pathologies develop. Its deficiency manifests itself in the form of epileptic convulsions, various dermatitis, hypofunction of the bone marrow. One of the forms of vitamin b6 - pyridoxine hydrochloride - a substance that is prescribed for the treatment of beriberi. The drug of the same name restores a full-fledged metabolism, activating the activity of enzymes.

What is Pyridoxine Hydrochloride

Long-term infections, malnutrition, malabsorption syndrome and prolonged stress cause a lack of vitamin b6 in the body. Pyridoxine hydrochloride is a drug that has an action that compensates for this deficiency. Pyridoxine was accidentally discovered in the 1920s. This is a highly soluble transparent substance that does not accumulate in the human body, and after ingestion is completely excreted after 5-8 hours.

Pyridoxine hydrochloride belongs to the group of active coenzymes. Outwardly, this substance looks like transparent crystals, soluble in ethanol and water, having a lot of useful properties. The resulting alcohol or aqueous solution mixes perfectly with essential oils and fats. The substance does not oxidize in air, but is easily decomposed by light. Pyridoxine hydrochloride melts when heated without chemical degradation.

Compound

Pyridoxine hydrochloride is a drug belonging to the group of drugs that affect tissue metabolism in the human body. The active ingredient in its composition is 2-Methyl-3-hydroxy-4,5-di-(hydroxymethyl) or pyridine hydrochloride. It is a fine-grained white powder of sour-bitter taste, odorless. The excipients of the drug include:

• talc;
• calcium stearate;
• colloidal silicon dioxide;
• microcrystalline cellulose;
• dextrose monohydrate (glucose).

pharmachologic effect

Pyridoxine normalizes the functioning of the central and peripheral nervous system, participates in the metabolism of aminocarboxylic acids: glutamic, tryptophan, methionine and others. Vitamin b6 contributes to normal lipid metabolism. The use of Pyridoxine will help start the body's metabolic processes by converting the active substance into pyridoxal-6-phosphate. This compound is a coenzyme substance that activates the enzymes necessary for the normal metabolism of amino acids and lipids.

Release form

Vitamin Pyridoxine is produced in the form of tablets and injections. The tablet form of the drug has a white color, a round flat-cylindrical surface, on which there is a dividing line on one side. Tablets are packaged in 50 pieces in glass bottles, which are placed in a cardboard box with instructions. Pyridoxine hydrochloride solution is packaged in ampoules for injections (injections) of 1 ml. They are sold 10 pieces in one carton with instructions and an ampoule knife. The shelf life of the medicine is 3 years from the date of manufacture.

What is vitamin b6 for?

In the human body, pyridoxine (vitamin B6) performs many important functions. With its lack of blood becomes viscous, which leads to the formation of blood clots, increases the risk of stroke, heart attack. Also, a deficiency of pyridoxine reduces the immune system, after which bacterial and viral infections easily develop. Vitamin b6 promotes the production of antibodies that protect the body from pathogenic microorganisms. Functions that pyridoxine performs:

• regulates cholesterol levels;
• improves the synthesis of red blood cells;
• in violation of the water balance has a diuretic effect (diuretic);
• regulates the balance of potassium, glucose, magnesium, sodium;
• contribute to the normal functioning of the adrenal glands and thyroid gland;
• regulates the acidity of the stomach;
• stabilizes the level of progesterone, estrogen, testosterone (male and female sex hormones).

When Reception Is Essential

• women 2 weeks before the onset of menstruation, when the body produces a large amount of estrogen;
• people taking steroids;
• women who drink hormonal contraceptives;
• obese people, as their metabolism is slowed down;
• patients using antidepressants;
• heavy smokers;
• those who abuse alcohol;
• AIDS patients;
• drug addicts;
• those who regularly experience physical, mental stress.

Instructions for use

Doctors prescribe pyridoxine in tablets or as a solution for vitamin B6 deficiency (hypovitaminosis) or complete absence (avitaminosis). Often the drug is prescribed in the complex therapy of the following diseases:

• neurodermatitis (exudative diathesis);
• toxicosis in pregnant women;
• chronic dermatitis;
• hepatitis;
• chorea;
• microcytic and hypochromic anemia;
• parkinsonism;
• stomach ulcer or 12 duodenal ulcer.

Pills

For the prevention of various diseases, adults are prescribed oral tablets at a dosage of 2-5 mg / day. The daily dose of a child is 2 mg. Therapeutic dosages for adults are higher - from 50 to 100 mg daily, which are divided into several doses. It is recommended to drink tablets after meals with a small amount of water. The course of admission is prescribed by the doctor. According to the annotation, the average duration of treatment is from 1 to 2 months. If anti-tuberculosis therapy is carried out, then for the prevention of violations of the functions of the nervous system, pyridoxine hydrochloride is prescribed at 5-10 mg / day.

Ampoules

The injection solution is also used for the treatment and prevention of beriberi or hypovitaminosis of vitamin b6. Additionally, water for injection is used. In pharmacies, the drug is sold strictly by prescription. The solution is administered intramuscularly, subcutaneously or intravenously. For adults and children, the daily dose is prescribed individually, depending on the severity of the condition. The daily requirement of the child is up to 20 mg. Adults are recommended 100 mg / day, but you can assign up to 600 mg / day (convulsive syndrome), a course of up to 25 days.

Pyridoxine hydrochloride during pregnancy

Taking the drug while waiting and breastfeeding (lactation) is allowed according to medical indications. The daily dose for pregnant women is standard, but should not exceed 100 mg / day. Vitamins Pyridoxine is prescribed for psycho-emotional disorder of a pregnant woman, severe toxicosis. The drug helps to maintain the necessary tone of the uterus, improves the immunity of the expectant mother, preventing the development of a variety of fetal diseases.

Side effects

Pyridoxine hydrochloride should be used strictly in the indicated dose, otherwise side effects may occur. Against the background of an overdose, an allergic reaction may occur in the form of urticaria, itching, redness of the skin. With rapid intravenous administration, convulsions and a feeling of squeezing of the limbs (a symptom of gloves or stocking) sometimes occur. In severe liver disease, it is recommended to halve the dose, since the risk of side effects on the drug increases.

Contraindications

The drug is generally well tolerated, and there is only one absolute contraindication to taking it - hypersensitivity to the active substance. Pyridoxine should be taken with caution in case of cardiac ischemia, peptic ulcer or duodenal ulcer. In order to avoid problems with the digestive tract, you should not prescribe a dosage for yourself or exceed the established doses.

drug interaction

With the combined use of pyridoxine hydrochloride with hormonal contraceptives in the blood plasma, the concentration of vitamin b6 may be exceeded. If you take the drug along with diuretics, then their action is potentiated. When taken with Levodopa, the effects of the latter are inhibited. The combined use of Pyridoxine and Cycloserine (Isonicothing hydrazide, Penicillamine) weakens the effectiveness of vitamin b6.

Analogues

Structural analogues that contain the active substance pyridoxine are Pyridoxine Bufus and Pyridoxine Vial. There are similar vitamins or vitamin-like drugs that are similar in pharmacological group:

1. Medobiotin. Ingredients: pyridoxine hydrochloride, calcium pantothenate, nicotinamide, alpha-tocopherol acetate riboflavin biotin. Prescribe a medicine for psycho-emotional disorders, disorders of the digestive tract, diseases of the skin, nails, hair.
2. Magvit. Ingredients: pyridoxine hydrochloride, magnesium citrate. It is indicated for lesions of the nervous system, muscle cramps, intestinal spasms and other manifestations of beriberi b6.
3. Magnelis. Ingredients: pyridoxine hydrochloride and magnesium lactate. It is prescribed for convulsions, stress, it is effective for psoriasis, it is necessary for the normalization of intestinal motility.

Instructions for use

Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.

general characteristics

international and chemical names: pyridoxine, (5-hydroxy-6-methylpyridine-3,4-diyl)-dimethanol hydrochloride);

basic physical and chemical properties: clear, colorless or slightly yellowish liquid;

compound: 1 ml of solution contains pyridoxine hydrochloride 50 mg;

Excipients: water for injections.

Release form. Injection.

Pharmacotherapeutic group

Simple drugs vitamins (vitamins- organic substances formed in the body with the help of intestinal microflora or supplied with food, usually vegetable. Necessary for normal metabolism and life). Pyridoxine hydrochloride. ATC code A11H A02.

Pharmacological properties

Pharmacodynamics. Water soluble vitamin B6. Plays an important role in metabolism (Metabolism- a set of chemical reactions that result in the synthesis or decomposition of substances and the release of energy. In the process of metabolism, the body perceives substances from the environment (mainly food), which, undergoing profound changes, turn into substances of the body itself, the constituent components of the body); necessary for the normal functioning of the central and peripheral nervous system (Peripheral nervous system- part of the nervous system, represented by nerve fibers and nerve nodes that lie outside the central nervous system). Pyridoxine in its phosphorylated form is coenzyme (Coenzymes- small non-protein molecules that specifically bind to the corresponding proteins, called apoenzymes, and play the role of the active center or prosthetic group of the enzyme molecule) many enzymes (Enzymes- specific proteins that can significantly accelerate chemical reactions occurring in the body, without being part of the final reaction products, i.e. are biological catalysts. Each type of enzyme catalyzes the transformation of certain substances (substrates), sometimes only a single substance in a single direction. Therefore, numerous biochemical reactions in cells are carried out by a huge number of different enzymes. Enzyme preparations are widely used in medicine) that carry out the processes of decarboxylation and transamination amino acids (Amino acids- a class of organic compounds that have the properties of both acids and bases. Participate in the metabolism in the body. About 20 essential amino acids are the building blocks of all proteins). Actively participates in metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with the environment and adaptation to changes in external conditions) tryptophan, methionine, cysteine, glutamine and other amino acids, metabolism histamine (Histamine is a derivative of the amino acid histidine. It is contained in an inactive, bound form in various organs and tissues, and is released in significant quantities during allergic reactions, shock, and burns. Causes expansion of blood vessels, contraction of smooth muscles, increased secretion of hydrochloric acid in the stomach, etc.), fat metabolism, normalizes lipid metabolism with atherosclerosis (Atherosclerosis- a systemic disease characterized by damage to the arteries with the formation of lipid (mainly cholesterol) deposits in the inner lining of the vessels, which leads to a narrowing of the lumen of the vessel up to complete blockage), raises diuresis (Diuresis- the amount of urine excreted in a certain time. In humans, daily diuresis averages 1200-1600 ml) potentiates the action of diuretics.

Pharmacokinetics. Metabolized in the liver to form pharmacologically active metabolites (Active metabolites- metabolites of drugs with biological (pharmacological) activity. Active metabolites may have drug-like biological activity)- pyridoxal phosphate and pyridoxamino phosphate. Distributed predominantly in muscle, liver and CNS (CNS- the main part of the nervous system, represented by the spinal cord and brain. Functionally, the peripheral and central nervous systems represent a single whole. The most complex and specialized part of the central nervous system is the cerebral hemispheres). Penetrates through placenta (Placenta- an organ that communicates and exchanges substances between the mother's body and the fetus during fetal development. It also performs a hormonal and protective function. After the birth of the fetus, the placenta, along with the membranes and the umbilical cord, are released from the uterus) and into breast milk. Excreted by the kidneys (when administered intravenously with bile (Bile- a secret produced by the glandular cells of the liver. Contains water, bile salts, pigments, cholesterol, enzymes. Promotes the breakdown and absorption of fats, enhances peristalsis. The human liver secretes up to 2 liters of bile per day. Preparations of bile and bile acids are used as choleretic agents (allohol, decholine, etc.)) about 2% is displayed.

Indications for use

Hypo- and avitaminosis B6, toxicosis of pregnant women, atherosclerosis, anemia (Anemia- a group of diseases characterized by a decrease in red blood cells or hemoglobin)(including sideroblastic), leukopenia (Leukopenia- the content of leukocytes in peripheral blood is less than 4000 per 1 μl, due to the impact on the body of various damaging factors) various genesis, diseases nervous system (Nervous system- a set of formations: receptors, nerves, ganglia, brain. Carries out the perception of stimuli acting on the body, the conduction and processing of the resulting excitation, the formation of response adaptive reactions. Regulates and coordinates all body functions in its interaction with the external environment)(sciatica, neuritis, neuralgia, parkinsonism (parkinsonism- a neurological syndrome caused by a malfunction in the functioning of the exchange of adrenaline, norepinephrine, dopamine and their ratio in the subcortical nerve nodes (ganglia). It is characterized by rhythmic muscle tremor (fingers tremble, sometimes lips and other parts of the body), rigidity, a decrease in the volume and speed of movements, hypokinesia), Little's disease), involutional depression (Depression- mental disorder: dreary, depressed mood with pessimism, monotony of ideas, decreased urges, inhibition of movements, various somatic disorders), sharp and chronic hepatitis (chronic hepatitis- damage to hepatocytes caused by various causes, characterized by hepatocellular necrosis and inflammation, lasting more than 6 months), seborrhoeic and non-seborrheic dermatitis (Dermatitis- an inflammatory reaction that occurs as a result of direct exposure to the skin of external factors), shingles (Shingles(Herpes zoster) - a herpetic skin lesion, which is characterized by a group arrangement of small vesicles on an erythematous or edematous base), neurodermatitis, psoriasis (Psoriasis- a chronic hereditary skin disease with diverse clinical manifestations. The most common common psoriasis is abundantly scaly papules and plaques on the scalp, elbows, forearms, hands, shins, feet, lower back, buttocks. Complaints of itching. In this disease, keratinocytes are formed 28 times more than normal), exudative diathesis, air and seasickness (Seasickness- a painful condition that develops when motion sickness on the water. Especially often and fully manifested at sea), Meniere's disease (Meniere's disease- a symptom complex resulting from impaired auditory and vestibular functions); for decreasing toxic (Toxic- poisonous, harmful to the body) effects of anti-tuberculosis drugs.

Dosage and administration

Administered intramuscularly, intravenously or subcutaneously, especially if due to intestinal malabsorption (Malabsorption in the intestine- violation of the active process of penetration of nutrients and microelements through intestinal enterocytes into the internal environment of the body) taking the drug inside is not possible.
Parenterally (parenteral- dosage forms administered bypassing the gastrointestinal tract, by applying to the skin and mucous membranes of the body; by injection into the vascular bed (artery, vein), under the skin or muscle; by inhalation, inhalation (see Enteral)) with all the indicated routes of administration, the daily dose for adults is 0.05-0.1 g. For children, the dose is prescribed by the doctor individually and another vitamin B6 preparation with a lower dosage is used.
The course of treatment is 30 days.
In parkinsonism, 2 ml of a 5% solution is administered intramuscularly per day. The course of treatment is 20-25 days, after 2-3 months a second course is carried out. According to another treatment regimen for this disease, a 5% solution is administered intramuscularly, at an initial daily dose of 50-100 mg, and then the dose is increased daily by 50 mg and adjusted to 300-400 mg per day, once. Therapy (Therapy- 1. The field of medicine that studies internal diseases, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate a type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) at the same time it is carried out by courses of 12-15 days.
For the treatment of involutional depression, the drug is administered intramuscularly at a dose of 200 mg per day.
In the treatment of sideroblastic anemia, the drug is administered intramuscularly, 0.1 g, 2 times a week (at the same time it is recommended to take folic acid, riboflavin (Riboflavin is a water soluble vitamin. Contained in dairy and meat products, salad vegetables, chicken yolk, brewer's yeast. The lack of this vitamin in the body leads to skin lesions, visual impairment, gastritis, colitis), vitamin B12).

Side effect

Allergic reactions (skin rash, hives (Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes)). There are also isolated cases anaphylactic shock (Anaphylactic shock- a symptom complex of acutely occurring general severe manifestations of allergic reactions of an immediate type, mainly characterized by initial excitation and subsequent depression of the function of the central nervous system, bronchospasm, and severe arterial hypotension) already after 1-2 injections (Injection- injection, subcutaneous, intramuscular, intravenous, etc. introduction into the tissues (vessels) of the body of small amounts of solutions (mainly drugs)) pyridoxine.

Contraindications

Hypersensitivity to the drug.

Overdose

Overdose symptoms: increased side effects (allergic reactions: skin rash, urticaria, anaphylactic shock).

Treatment: drug withdrawal, symptomatic therapy.

Application features

In severe liver damage, pyridoxine in large doses can cause a deterioration in its function.
Use with caution in gastric ulcer and duodenum (Duodenum- the initial section of the small intestine (from the outlet of the stomach to the jejunum). The length of the human duodenum is equal to the diameters of 12 fingers (hence the name)), ischemic heart disease.

Interaction with other drugs

Do not prescribe simultaneously with levodopa, because. pyridoxine weakens the effect of the latter. Do not mix in the same syringe with solutions of vitamins B1 and B12. Hormonal contraceptives, hydralazine, penicillamine increase the need for pyridoxine. The drug reduces the neurotoxic effect of isoniazid, and also eliminates the side effects of tricyclic antidepressants (Antidepressants- means that improve mood, relieve anxiety and stress, increase mental activity. Used to treat depression, apressin, cyclosporine, lowers the level of phenobarbital, diphenine in the blood.
Effective with prolonged use of chloramphenicol to prevent ophthalmic complications. Pyridoxine increases diuresis and enhances the effect diuretics (Diuretics- medicinal substances that increase the excretion of urine by the kidneys and thereby contribute to the removal of excess water and sodium chloride from the body).
In patients with chronic (Chronic- a long, ongoing, protracted process, occurring either constantly or with periodic improvements in condition) heart failure, the drug potentiates the action of cardiac glycosides.

Product General Information

Terms and conditions of storage. Store in a place protected from light and out of the reach of children, at a temperature not exceeding 25 С.
Shelf life - 3 years.

Holiday conditions. On prescription.

Package. Solution for injection 5%, 1 ml in ampoules No. 10.

Manufacturer.LLC "Pharmaceutical company "Health".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

Preparations with the same active ingredient

• - "Darnitsa"

This material is presented in free form on the basis of the official instructions for the medical use of the drug.