Nazivin oxymetazoline instructions for use. Nazivin for children - instructions, features of the use of drops and spray in childhood
Today, pharmacies are simply overflowing with various compounds that can cope with nasal congestion in children. But it’s not so easy to choose, because drops need to be applied, taking into account the individual characteristics of the child’s body and the course of the disease. Nazivin remains the best option today. We will consider the properties of this drug, application and instructions in the article.
The effect of Nazivin nose drops
The presented medication contains oxymetazoline. Thanks to this, Nazivin has a vasoconstrictor effect. By using the medicine topically, it is possible to reduce the inflammatory process of the nasal mucosa, removing its swelling and discharge from the nasal cavity. If you follow the instructions and dosage, you can restore nasal breathing.
Restoring aeration of the paranasal sinuses helps eliminate swelling, as well as protect against the development of bacterial complications. The most dangerous are sinusitis, sinusitis and otitis media.
If you use the drug topically in the dosages indicated in the instructions, the mucous membrane will not be irritated, and there will be no redness. In addition, Nazivin does not have a systemic effect. The positive effect is noticeable after just a few minutes. The resulting effect will last for 12 hours.
Read how to use Nazivin correctly for newborns.
Required dosage and rules of use
Nazivin should only be used topically in the nose. Due to its unique composition and safe effect, the medicine can be prescribed not only to adults, but also to children. 
For babies up to one year old
For patients under 4 weeks of age, the drug should be used 1 drop in each nasal passage 3 times a day. When the baby is from 5 weeks to a year, you can drop 1-2 drops into each nostril 3 times a day.
From year
If the child is already one year old, then Nazivin should be used in the amount of 1-2 drops 3 times a day.
How many days to drip
The question always arises for how many days can a child receive Nazivin drips. To maintain the exact dosage of the medication used, there is a graduated pipette on which the number of drops is marked. If the child’s age corresponds to 1 drop, then take the medicine up to the 1 mark.
Treatment with Nazivin is necessary for 3-5 days. In this case, it is necessary to strictly adhere to the dosage indicated above. If you use the drops for longer than the specified period, then addiction occurs and it is no longer possible to get a positive effect from Nazivin.
Without the knowledge of the doctor, you cannot exceed the dose of the drug.
This form of the drug can be used to treat runny nose in patients who have not yet reached one year of age. If your baby is not yet 4 weeks old, then you need to use one spray in each nostril 2-3 times a day. From 5 weeks to one year of age, apply 2 sprays 2-3 times a day.
Price
You can purchase a drug that relieves nasal congestion at any pharmacy without a prescription. Children's Nazivin costs only 165 rubles.
Reviews
- Margarita, 34 years old: “When the child had a runny nose, I immediately began rinsing her nose with saline solution. But he only allowed him to quickly remove the mucus, but only Nazivin was able to cope with nasal congestion. I used the drug for only 3 days and such an unpleasant symptom as a runny nose disappeared.”
- Elena, 25 years old:“I have been using Nazivin for a long time to treat my daughter’s runny nose. During all this time, we did not experience any side effects. Although my friend's situation is the opposite. When they used the drug, her son had a severe headache and a burning sensation.”
- Veronica, 45 years old: “Nazivin for children copes well with my grandson’s nasal congestion. He is 5 years old, but trips to the garden in the cold season always end with him getting sick. I tried many drops: Pinosol, Otrivin, but we were unable to get the same effect as from Nazivin. All we have to do is drip the child’s nose for 3-4 days, and the cold immediately goes away.”
Comparison with other drugs
Application of Nazol
The drug is produced specifically for the treatment of runny nose in young patients. With this treatment, it is possible to very quickly eliminate a runny nose, the cause of which is allergies, colds or viruses. If Nazivin does not help with a stuffy nose in a child, then you can try this remedy.
Nazol is a nasal drug that has a mild vasoconstrictor effect.
If we talk about Nazivin, it also has a vasoconstrictor effect, but also actively fights swelling of the nasal mucosa, making breathing easier. The main component is oxymetazoline hydrochloride. It is he who relieves swelling of the mucous membrane, and also, unlike Nazol, effectively removes accumulated mucus. Nazol or Nazivin, children will have to choose for themselves which is better to instill.
Vibrocil
Let us first consider Vibrocillus. This spray is very effective and quickly relieves nasal congestion. Vibrocil can be used in the form of drops for newborns and in the form of a spray for older children. To eliminate children's runny nose, this medication is considered the most optimal. It should not be used by children who are prone to allergies. The answer to the question of which is better is Vibrocil or Nazivin for children only by trying both remedies.
The spray can be used for any colds.
Nazivin affects very quickly and strongly, powerfully affecting the delicate mucous membrane of the nose. If you choose between these two drugs, you should be guided by the age of the baby.
Otrivin
Nazivin, unlike Otrivin, contains a smaller percentage of the main component. For this reason, Nazivin has a safe effect on children, but this does not affect its effectiveness in any way.
The medicine can be purchased at a pharmacy at a price of 190 rubles.
What to do if the remedy does not help
As noted earlier, the duration of treatment with the presented remedy should not exceed 5 days. If relief does not occur during this period, then you should consult a doctor. After examining the child, he will be able to draw a conclusion about the advisability of further use of Nazivin or prescribing another drug. In this case, you should not make independent decisions, otherwise you can harm the baby.
What happens if an adult drug is instilled into a child?
It is not recommended to use adult Nazivin for the treatment of children's runny nose, but if such a situation exists, then before use it is necessary to dilute the drops with purified water in a 1:1 ratio.
Cheap analogues
Analogues are a great way to save money and still get the desired result. The cheapest analogues of Nazivin include:
- Nesopin - 84 rub.
- Xylene - 28 rub.
- Rinostop - 17 rub.
- Rhinonorm - 89 rub.
- For nose - 120 rub.
- Nazol - 140 rub.
- Fazin - 102 rub.
Video
This video will tell you about the use of Nazivin and its analogues for the treatment of runny nose in children.
Nazivin is a drug for quickly eliminating a runny nose in a child. The effectiveness of its use has been proven over the years and many mothers, according to reviews, are satisfied with this treatment and the price as well. If you strictly follow the instructions and do not exceed the duration of therapy, then the entire treatment process will go quickly and there will be no side effects. You will find a list of children's nasal drops for a runny nose.
Composition and release form
in dark glass bottles with a pipette cap, 5 ml; 1 bottle in a cardboard pack.
in dark glass bottles with a pipette cap, 10 ml; 1 bottle in a cardboard pack.
in polyethylene bottles with a sprayer of 10 ml; 1 bottle in a cardboard pack.
Description of the dosage form
An aqueous solution of oxymetazoline hydrochloride at a concentration of 0.01, 0.025 and 0.05%.
pharmachologic effect
pharmachologic effect- alpha-adrenomimetic, vasoconstrictor.Pharmacodynamics
Being an imidazoline derivative, at low concentrations it mainly has an α 2 -adrenomimetic effect, and at high concentrations it also acts on α 1 -adrenergic receptors.
Constricts blood vessels at the site of application, reduces swelling of the nasal mucosa and upper respiratory tract. When applied topically at therapeutic concentrations, it does not irritate the mucous membrane and does not cause hyperemia.
Studies of radiolabeled oxymetazoline have shown that this rhinological agent, administered through the nose, has no systemic effect.
Indications of the drug Nazivin ®
Acute rhinitis (including allergic), vasomotor rhinitis, paranasal sinusitis, eustachitis, otitis media.
Constriction of blood vessels in the mucous membrane for diagnostic purposes (under medical supervision).
Contraindications
Hypersensitivity to the components of the drug, atrophic rhinitis, angle-closure glaucoma.
Age up to 1 year - for Nazivin ® 0.025 and 0.05%; age up to 6 years - for Nazivin ® 0.05%.
Use during pregnancy and breastfeeding
During pregnancy and breastfeeding, the recommended dosage should not be exceeded. The drug should be used only after a careful assessment of the balance of benefit and risk for the mother and fetus.
Side effects
Sometimes - burning or dryness of the nasal mucosa, sneezing; rarely - a strong feeling of nasal congestion (reactive hyperemia); very rarely - anxiety, insomnia, fatigue, headache, nausea.
Repeated overdose with local nasal use sometimes leads to such systemic sympathomimetic effects as increased heart rate (tachycardia) and increased blood pressure.
Interaction
Significant overdose or ingestion of Nazivin ® and taking tricyclic antidepressants or MAO inhibitors simultaneously or immediately before using Nazivin ® can lead to an increase in blood pressure.
There are currently no known cases of drug incompatibility.
Directions for use and doses
Intranasally. Nasal drops: adults and children over 6 years old - 1-2 drops in each nasal passage 2-3 times a day of a 0.05% solution; children: infants up to 4 weeks - 1 drop of 0.01% solution 2-3 times a day, from the 5th week of life to 1 year - 1-2 drops 2-3 times a day, from 1 year to 6 years - 1-2 drops 2-3 times a day of a 0.025% solution.
To ensure dosage accuracy, the bottle of Nazivin ® 0.01% nasal drops has a graduated pipette with markings on the number of drops.
The following procedure has also been proven effective: depending on age, 1-2 drops of a 0.01% solution are applied to cotton wool and wiped over the nasal passages.
Nasal spray 0.5%: adults and children over 6 years old - 1 injection into each nasal passage 2-3 times a day.
The drug is used for 3-5 days.
Overdose
Symptoms(after a significant overdose or accidental ingestion): constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and the possible development of coma.
Treatment: gastric lavage, taking activated carbon and urgently contacting a doctor.
Precautionary measures
After long-term use or use of cold remedies containing oxymetazoline in dosages exceeding the recommended ones, a general effect on the cardiovascular system and the central nervous system cannot be ruled out. In these cases, the ability to operate a vehicle or equipment may be impaired.
special instructions
Long-term use of decongestants for nasal instillation may lead to a weakening of their effect. Abuse of these drugs can cause mucosal atrophy and reactive hyperemia with rhinitis medicamentosa, as well as damage to the mucosal epithelium and inhibition of epithelial activity. Long-term use and overdose should be avoided.
Storage conditions for the drug Nazivin ®
At a temperature not exceeding 25 °C.Keep out of the reach of children.
Shelf life of the drug Nazivin ®
3 years.Do not use after the expiration date stated on the package.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| H66 Suppurative and unspecified otitis media | Bacterial ear infections |
| Inflammation of the middle ear | |
| ENT infections | |
| Infectious and inflammatory diseases of the ENT organs | |
| Infectious and inflammatory diseases of the ear | |
| Infectious diseases of the ENT organs with severe pain syndrome | |
| Ear infection | |
| Infectious otitis media | |
| Persistent inflammation of the middle ear in children | |
| Ear pain due to otitis media | |
| H68 Inflammation and obstruction of the auditory [Eustachian] tube | Eustacheite |
| Eustachite | |
| Eustachian tube catarrh | |
| Acute eustachitis | |
| J00 Acute nasopharyngitis [runny nose] | Viral rhinitis |
| Inflammation of the nasopharynx | |
| Inflammatory disease of the nose | |
| Purulent rhinitis | |
| Nasal congestion | |
| Nasal congestion due to colds and flu | |
| Difficulty in nasal breathing | |
| Difficulty in nasal breathing due to colds | |
| Difficulty in nasal breathing | |
| Difficulty in nasal breathing due to colds | |
| Infectious and inflammatory disease of ENT organs | |
| Nasal hypersecretion | |
| Runny nose | |
| Acute respiratory infection with symptoms of rhinitis | |
| Acute rhinitis | |
| Acute rhinitis of various origins | |
| Acute rhinitis with thick purulent-mucous exudate | |
| Acute nasopharyngitis | |
| Swelling of the nasopharyngeal mucosa | |
| Rhinitis | |
| Rhinorrhea | |
| Rhinopharyngitis | |
| Rhinopharyngitis | |
| Severe runny nose | |
| J01 Acute sinusitis | Inflammation of the paranasal sinuses |
| Inflammatory diseases of the paranasal sinuses | |
| Purulent-inflammatory processes of the paranasal sinuses | |
| Infectious and inflammatory disease of ENT organs | |
| Sinus infection | |
| Combined sinusitis | |
| Exacerbation of sinusitis | |
| Acute inflammation of the paranasal sinuses | |
| Acute bacterial sinusitis | |
| Acute sinusitis in adults | |
| Subacute sinusitis | |
| Acute sinusitis | |
| Sinusitis | |
| J30 Vasomotor and allergic rhinitis | Allergic rhinopathy |
| Allergic rhinosinusopathy | |
| Allergic diseases of the upper respiratory tract | |
| Allergic respiratory diseases | |
| Allergic runny nose | |
| Allergic rhinitis | |
| Allergic rhinitis seasonal | |
| Vasomotor rhinitis | |
| Long-term allergic rhinitis | |
| Year-round allergic rhinitis | |
| Year-round allergic rhinitis | |
| Year-round or seasonal allergic rhinitis | |
| Year-round rhinitis of allergic nature | |
| Runny nose, vasomotor allergic | |
| Exacerbation of hay fever in the form of rhinoconjunctival syndrome | |
| Acute allergic rhinitis | |
| Swelling of the nasal mucosa | |
| Swelling of the nasal mucosa | |
| Swelling of the nasal mucosa | |
| Swelling of the nasal mucosa | |
| Swelling of the nasal mucosa | |
| Hay fever | |
| Persistent allergic rhinitis | |
| Rhinoconjunctivitis | |
| Rhinosinusitis | |
| Rhinosinusopathy | |
| Seasonal allergic rhinitis | |
| Seasonal allergic rhinitis | |
| Hay rhinitis | |
| Chronic allergic rhinitis |
Nazivin– a drug in the form of nasal drops or spray, which has a pronounced anti-edematous and vasoconstrictor effect. The drug contains an active component - oxymetazoline - which stimulates alpha-adrenergic receptors located in the smooth muscle layer of the vessels of the nasal mucosa. The drug eliminates rhinorrhea, swelling of the nasal mucosa and paranasal sinuses, and facilitates nasal breathing. When using the drug in therapeutic doses, no stimulation of alpha1-adrenergic receptors was observed, however, when using excessive doses, some effect of oxymetazoline on alpha1-adrenergic receptors is possible.
The drug is not absorbed into the systemic circulation and does not have a systemic effect.
Indications for use
The drug is used to treat patients with acute rhinitis of various etiologies, including allergic rhinitis.
The drug is prescribed to patients with vasomotor rhinitis, sinusitis, inflammation of the Eustachian tube and middle ear, as well as acute respiratory diseases that are accompanied by impaired nasal breathing.
In addition, the drug can be prescribed in preparation for various diagnostic procedures.
Mode of application
Nazivin 0.05% (nasal drops, spray):
Adults and children over 6 years of age are usually prescribed 1-2 drops (1-2 injections) of the drug 2-3 times a day.
Nazivin 0.025% (nasal drops):
Children aged 1 to 6 years are usually prescribed 1-2 drops of the drug 2-3 times a day.
Nazivin 0.01% (nasal drops):
Children aged from birth to 4 weeks are usually prescribed 1 drop of the drug 2-3 times a day.
Children aged 5 weeks to 1 year are usually prescribed 1-2 drops of the drug 2-3 times a day.
In addition to instilling the drug into the nasal passages, it is also possible to apply the required amount of the drug (1-2 drops) to a cotton swab and treat the nasal passages.
It should be borne in mind that with prolonged use of the drug, its therapeutic effect is somewhat reduced.
Side effects
The drug is usually well tolerated by patients; in isolated cases, a burning sensation and dryness of the nasal mucosa, reactive hyperemia, and sneezing were noted.
When using excessive doses of the drug for a long time, the development of tachycardia, arterial hypertension, disturbances in sleep and wakefulness, headache and nausea is possible.
Contraindications
Increased individual sensitivity to the components of the drug.
The drug is contraindicated in patients suffering from angle-closure glaucoma.
The drug is not used to treat patients suffering from atrophic rhinitis.
A drug Nazivin 0.05% is contraindicated in children under the age of 6 years, Nazivin 0.025% - in children under the age of 1 year.
Caution should be exercised when prescribing the drug to patients with arterial hypertension, tachycardia, atherosclerosis, diabetes mellitus, hyperthyroidism, as well as increased intraocular pressure and pheochromocytoma.
Pregnancy
The drug can be used during pregnancy as prescribed by the attending physician, who must carefully weigh the expected benefits for the mother and the potential risks for the fetus.
If it is necessary to use the drug during lactation, the minimum effective dose of oxymetazoline should be used.
Interaction with other drugs
When the drug is used in combination with monoamine oxidase inhibitors and tricyclic antidepressants, the development of arterial hypertension is possible.
Overdose
When using excessive doses of the drug, as well as when accidentally taking the drug orally, nausea, vomiting, increased body temperature, cardiac arrhythmias, arterial hypertension, respiratory problems, pulmonary edema and cardiac arrest may develop. In addition, some patients experienced depression of the functions of the central nervous system and the development of drowsiness, arterial hypotension, bradycardia, respiratory arrest and coma.
There is no specific antidote. In case of accidental oral administration of the drug, gastric lavage and enterosorbents are indicated. In case of overdose, symptomatic therapy is carried out.
Release form
Nasal drops, 10 ml in a bottle, 1 bottle in a cardboard box.
The most common causes of a runny nose are various viruses, allergens or pathogenic bacteria. They provoke inflammation of the mucous membrane and its swelling, excessive nasal discharge, and interfere with breathing through the nose, eating and sleeping peacefully at night.
To combat such symptoms in children, vasoconstrictor medications are often used. One of the medications in this group is Nazivin. In what forms is it produced, how does it affect the child’s body, what dose is recommended in childhood, and how to properly instill Nazivin in the nose of a child older than one year?
Release form and composition
The drug is released in the form of an almost transparent liquid that has no color or has a slight yellow tint. The main ingredient of this solution is oxymetazoline in the form of hydrochloride. The concentration of this substance varies, as does the packaging of the medicine. Nazivin is presented in pharmacies:
- Drops in the nose. They are available in glass bottles equipped with special pipettes on the cap. The concentration of such a drug can be 0.01%, 0.025% and 0.05%. The drug with the lowest dosage is intended for children under one year old and is presented in a 5 ml bottle. Drops with a concentration of 0.025% and 0.05% are available in 10 ml in one bottle. In addition to oxymetazoline, they contain disodium edetate, dihydrogen phosphate and sodium hydrogen phosphate, as well as water, sodium hydroxide and benzalkonium chloride.
- Nasal spray. It is produced in plastic bottles that have a sprayer. Inside one bottle there is 10 ml of solution, and the concentration of oxymetazoline in it is 0.05%, which corresponds to a dosage of 500 µg/1 ml. Additional components of the medicine are citric acid, glycerol, benzalkonium chloride, purified water and sodium citrate.
In addition, Nazivin Sensitive can be seen in the assortment of pharmacies. The main component of this medicine (oxymetazoline). Indications, possible negative effects and contraindications are completely the same as regular Nazivin. First of all, the drug labeled “sensitive” is intended for children prone to allergies, since it does not include benzalkonium chloride and is less likely to cause an allergic reaction.
One of the forms of Nazivin Sensitive are drops that contain 0.01% of the active ingredient and are used in the treatment of infants. For children older than one year, the medication is produced in the form of a dosed spray:
- With an active ingredient content of 11.25 mcg per dose, which corresponds to a concentration of 250 mcg/1 ml.
- Containing oxymetazoline in 1 dose in the amount of 22.5 mcg, that is, with a concentration of 500 mcg/1 ml.
Each of these medications is available in 10 ml bottles and contains approximately 220 doses of medication. The bottles are made of plastic and equipped with a special dispensing device.
Operating principle
The active compound Nazivin affects alpha-2 adrenergic receptors, resulting in a narrowing of small vessels that are located in the nasal passages. Use of the medicine:
- Reduces swelling and hyperemia of the nasopharyngeal mucosa.
- Reduces the volume of nasal discharge.
- Helps restore breathing through the nose.
- Additionally, it affects the paranasal sinuses, as well as the middle ear, preventing complications of a runny nose in the form of sinusitis or otitis.
- It has a therapeutic effect only at the treatment site.
- Does not provoke redness and irritation of the mucous membrane inside the nasal passages.
The medication begins to act literally in the first minutes after it enters the nose, and the vasoconstrictor effect after treatment with the solution lasts up to 12 hours.
Indications
In childhood, Nazivin is in demand:
- In the treatment of ARVI, if the disease manifests itself as a runny nose.
- In the treatment of allergic rhinitis.
- In the treatment of rhinitis, which is called vasomotor.
- In combination with other medications for eustachitis, adenoids, otitis media or sinusitis.
- Before performing any diagnostic manipulations in the nasal passages.
What forms are used for children over one year old?
For infants, 0.01% drops are produced, but for older children, the amount of active compound in this Nazivin will be insufficient. At the age of one to six, drops containing 0.025% oxymetazoline are prescribed. For the treatment of children over 6 years of age, a 0.05% solution in any form is prescribed.
As for Nazivin Sensitive, only a spray is used in children over one year of age, one dose of which contains 11.25 mcg of the active ingredient. A more concentrated product containing 22.5 mcg of oxymetazoline in each dose is used from the age of six.
What to choose?
When choosing the most optimal form of medication for a child, first of all, take into account the concentration of the drug, and then decide on the packaging. Let us note that it is very convenient to use both types of Nazivin - the drops are easily dosed and fall directly into the baby’s nose thanks to the curved shape of the pipette built into the lid, and the spray is sprayed with a light pressure over the entire mucous membrane in the required dose. However, in practice, the spray form seems more suitable to most mothers, since you do not need to lie down to administer the drug, and the risk of overdose with such a drug is minimal.
Contraindications
Treatment with Nazivin is prohibited:
- If you are hypersensitive to oxymetazoline or another ingredient of the solution.
- For angle-closure glaucoma.
- With rhinitis occurring in an atrophic form.
If a child has any diseases of the cardiovascular system, diabetes mellitus is detected, or there is thyrotoxicosis, Nazivin should be dripped or injected with caution.
Side effects
Side effects include:
- Sometimes after administration of Nazivin into the nose, negative local symptoms such as a feeling of dryness, sneezing, slight burning, and discomfort in the nasal passages occur.
- After the cessation of action, reactive hyperemia is often observed and the child begins to complain of nasal congestion.
- In some children, the drug provokes restless behavior, nausea, sleep disturbances, fatigue, and headaches.
- Long-term use of the solution/drops causes addiction and medicinal rhinitis. In addition, very long treatment can cause atrophic changes in the nasal mucosa.
Instructions for use
Before injecting/dropping Nazivin, you should clean the nasal passages, removing excess secretions from them. To do this, it is recommended to use a syringe or an aspirator, because the use of cotton swabs can be dangerous, especially at an early age. Before using the drops, the small patient is placed on a flat surface and the head is tilted back slightly. An older child is asked to sit down and tilt his head back slightly. The medication is first dripped into one nasal passage so that the drug hits the side wall, and then the same steps are repeated for the second nostril.
If a spray is used, the child should be warned to hold his breath. After finishing the procedure, wipe off the excess solution that has flowed out of the nose with a cotton pad or napkin.
For patients from 1 to 6 years of age, the solution is prescribed in the following single doses:
- One or two drops of 0.025% Nazivin in the form of nasal drops.
- One injection of Sensitive spray containing 11.25 mcg of oxymetazoline in each dose.
If the child is already 6 years old, then use the following single dosages:
- One drop of Nazivin 0.05%, produced in nasal drops (sometimes 2 drops at once).
- 1 injection of 0.05% Nazivin spray.
- One injection of the drug Sensitive containing 22.5 mcg of active compound in each dose.
The medicine is alternately administered in the indicated doses, first into one and then into the second nasal passage. The frequency of use is twice a day, and if necessary, the medicine is sprayed or dripped three times a day. The duration of treatment with the solution at any age is 3-5 days. If the medication does not help within this period, you should not continue treatment. In such a situation, it is best to consult a doctor and together with him choose another therapy.
Overdose
Due to an excessive dose of Nazivin, vomiting, constriction of the pupils, increased heart rate, respiratory failure, fever, arrhythmia and other symptoms appear. If the overdose is severe, pulmonary edema, mental disorders and even coma may occur. Having discovered poisoning, after lavaging the stomach, you must immediately call an ambulance.
Interaction with other drugs
Like many other vasoconstrictor medications, Nazivin cannot be used with MAO blockers or tricyclic antidepressants. Also, you should not inject any other means that constrict blood vessels (for example, Otrivin or Xylene) into the nasal passages along with Nazivin, as this will increase the side effects of the drops or spray.
Terms of sale
All forms of Nazivin are classified as over-the-counter medications, so you can easily purchase the medicine at most pharmacies. The price of the drug depends on its form and concentration, for example, 0.05% Nazivin spray costs an average of 140 rubles, and for 10 ml of 0.025% drops you need to pay from 130 to 150 rubles. Sensitive medications are slightly more expensive - 160-180 rubles per bottle.
Storage conditions and shelf life
It is recommended to keep Nazivin and Nazivin Sensitive at home at temperatures up to 25 degrees Celsius in a place where the medication will be securely hidden from small children. The shelf life of all forms of the medicine is 3 years. If it has expired, dripping or squirting the solution into the child’s nose is unacceptable. The date after which the medicine is no longer used is marked on the packaging of the spray or drops and does not depend on the time of opening.
Instructions for medical use
medicine
NAZIVIN ®
Tradename
Nazivin ®
International nonproprietary name
Oxymetazoline
Dosage form
Nasal drops 0.01%, 0.025% and 0.05%
Cleaving
1 ml of solution contains
active substance - oxymetazoline hydrochloride 0.1 mg, 0.25 mg and 0.5 mg,
Excipients: citric acid monohydrate, sodium citrate dihydrate, glycerol (85%), benzalkonium chloride (50% solution), purified water.
Description
Almost transparent, colorless to slightly yellowish solution
Pharmacotherapeutic group
Preparations for the treatment of nasal diseases. Decongents and other drugs for topical use. Sympathomimetics. Oxymetazoline
ATX code R01AA05
Pharmacological properties
Pharmacokinetics
When administered locally intranasally, the drug does not have a systemic effect. After instillation into the nose, the effect of oxymetazoline occurs quickly:
For the 0.05% form for a few seconds (average 20 seconds)
For 0.025% and 0.01% forms in a few minutes
The duration of action of the drug is up to 12 hours. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces.
Pharmacodynamics
Nazivin ® has a vasoconstrictor effect, is a sympathomimetic, with a direct stimulating effect on alpha2-adrenergic receptors. When applied topically, nasal drops narrow the blood vessels of the nasal mucosa, eliminating swelling and hyperemia of the nasopharyngeal mucosa. Facilitates nasal breathing during rhinitis.
After the swelling of the mucous membrane is removed, the excretory channels open and expand for aeration of the paranasal sinuses and auditory tube. This stimulates the drainage function of the nasal cavities and prevents the development of bacterial complications. The antiviral, immunomodulatory and antioxidant effects of the active substance have been proven. The antiviral effect of oxymetazoline has been confirmed by studies using cultured cells infected with viruses (therapeutic approach). This causal mechanism of action has been demonstrated through inhibition of cold and runny nose viruses using the plaque reduction test, the residual viral infectivity test (viral titration), and the viral cytopathogenic effect inhibition (ZPE) test.
Indications for use
- acute respiratory diseases with symptoms of rhinitis (runny nose)
- allergic rhinitis
- vasomotor rhinitis
- improvement of secretion drainage during inflammation of the paranasal sinuses (sinusitis)
- eustachitis associated with rhinitis
- elimination of swelling of the nasal mucosa before diagnostic procedures
Directions for use and doses
Nazivin ® 0.01%, 0.025% and 0.05% drops are intended for intranasal use.
Nazivin ® 0.01% nasal drops used in infants under 4 weeks of age, 1 drop in each nasal passage 2-3 times a day. From the 5th week of life to 1 year - 1-2 drops in each nasal passage 2-3 times a day.
To ensure dosage accuracy, Nazivin bottle ® The 0.01% drops have a graduated pipette with drop number markings. For example, if 1 drop is prescribed, then the pipette should be filled with the solution to the 1 mark.
The following procedure has also been proven effective: depending on age, 1-2 drops of a 0.01% solution are applied to cotton wool and wiped over the nasal passages.
Nazivin ® 0.025% nasal drops prescribed to children aged 1 to 6 years, 1-2 drops in each nasal passage 2-3 times a day.
Nazivin ® 0.05% nasal drops prescribed for adults and children over 6 years old, 1-2 drops in each nasal passage 2-3 times a day
Nasal drops containing oxymetazoline should not be used for longer than 5-7 days unless otherwise directed by your doctor. Any repeated course of use of the drug must be preceded by a period without treatment of several days. Doses higher than recommended can only be used under medical supervision.
Single dose Nazivin ® 0.01%, 0.025% and 0.05% cannot be used more often than 3 times a day.
Side effects
Often(from ≥ 1% to< 10%):
- burning sensation or dryness of the nasal mucosa
- sneezing, especially in sensitive patients.
Infrequently(from ≥ 0.1% to< 1%):
- swelling and edema of the mucous membrane (feeling of nasal congestion) may become more intense (reactive hyperemia), nosebleeds
- hypersensitivity reactions (angioedema, rash, itching).
Rarely(from ≥ 0.01% to< 0,1%):
- increased heart rate, increased pulse rate and increased blood pressure.
Very rarely < 0,01% и единичные случаи:
- restlessness, insomnia, fatigue (drowsiness, sedation), headache, hallucinations (especially in children)
- arrhythmias
- apnea in infants and newborns
- convulsions
Contraindications
- hypersensitivity to oxymetazoline or to any excipient
- atrophic rhinitis
- Nazivin ® 0.025%, nasal drops should not be used in children under 1 year of age
- Nazivin ® 0.05%, nasal drops should not be used in children under 6 years of age
- cannot be used after transsphenoidal hypophysectomy or other surgical interventions on the dura mater
Drug interactions
Combined (simultaneous) use of oxymetazoline and
- tricyclic antidepressants
- tranylcypromine-type monoamine oxidase inhibitors
- hypertensive drugs
may lead to increased blood pressure. Therefore, if possible, it is not advisable to use these drugs simultaneously.
special instructions
Treatment in newborns and infants must be carried out with extreme caution.
In the following cases, this drug should only be used after a careful risk/benefit assessment:
- increased intraocular pressure, especially narrow-angle glaucoma
- severe cardiovascular disease (eg, coronary disease) and hypertension
- pheochromocytoma
- metabolic disorders (eg, hyperthyroidism, diabetes mellitus)
- prostatic hyperplasia
- porphyria
- patients being treated with monoamine oxidase inhibitors (MAO inhibitors) and other drugs that have the potential to increase blood pressure
With prolonged use of nasal remedies for the common cold or their overdose, their effectiveness may decrease. Improper use of nasal remedies for runny nose can cause:
- reactive hyperemia (resumption of symptoms after discontinuation of the drug)
- chronic swelling/edema of the nasal mucosa (rhinitis medicamentosa)
- atrophy of the mucous membrane.
Pregnancy and lactation
When used during pregnancy or breastfeeding, do not exceed the recommended dosage. Data obtained from a limited number of women receiving this drug during the first trimester of pregnancy did not indicate the development of any adverse reactions due to oxymetazoline that could affect the pregnancy or the health of the fetus/newborn.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
After long-term use of Nazivin ® , in dosages exceeding the recommended ones, a general effect on the cardiovascular system and central nervous system cannot be excluded. In these cases, the ability to operate a vehicle or equipment may be impaired.
Overdose
Symptoms: if recommended doses are exceeded or accidentally ingested, the following symptoms may appear: constriction of the pupils, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, collapse, cardiac depression, arterial hypertension, pulmonary edema, respiratory disorders. In addition, mental disorders may appear, as well as depression of the functions of the central nervous system, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and possible development of coma.
Treatment: taking activated carbon, gastric lavage, ventilation of the lungs with oxygen. To lower blood pressure - phentolamine 5 mg in saline (physiological) solution slowly IV or 100 mg orally. The use of vasopressor drugs is contraindicated. If necessary, prescribe medications to reduce fever symptoms and anticonvulsant therapy.
Release form and packaging
5 ml of the drug with a dosage of 0.01% in a dark glass bottle with a pipette cap. 10 ml of the drug with a dosage of 0.025% and 0.05% in a dark glass bottle with a pipette cap.
The bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard box.
Storage conditions
Store at a temperature not exceeding 25°C.
Keep out of the reach of children!
Shelf life
The period of use after the first opening is 6 months.
Do not use after expiration date
Conditions for dispensing from pharmacies
Over the counter
Manufacturer
Merck KGaA, Germany
Frankfurter Strasse 250, D-64293 Darmstadt
Registration Certificate Holder
