Lobelin recipe in Latin. The drug is dispensed from pharmacies strictly by prescription.

The main obstacle to quitting smoking is. An unsatisfied need to smoke leads to irritability, headache, loss of appetite, and decreased performance. So, lobelin is exactly the drug that is designed to help avoid the onset of withdrawal symptoms or minimize its manifestations.

Active ingredient and mechanism of action

Lobelin is a vegetable found in the leaves of Indian (Lobelia inflata). This substance acts on the same receptors as it starts the same biochemical processes, without having the harmful properties of nicotine. Therefore, lobelin therapy is also called replacement therapy. In addition, lobelin is a stimulant of the respiratory center.

Release forms

1% solution in ampoules and Lobesil tablets containing 0.002 g of lobelin hydrochloride.

Indications

Treatment of withdrawal symptoms of smokers.

Methods of application and doses

Solution: 10 - 15 drops of solution 4-5 times a day for a week. The course may be longer, but with further use of the solution, the dose must be gradually reduced.

Tablets "Lobesil": from the moment of quitting smoking, take one tablet 4-5 times a day for 7-10 days. Further reception is possible within 2-3 weeks, only the number of receptions must be reduced to 2-3.

In the event of a relapse of nicotine addiction, in the event of an intolerable need to smoke in a person who has already quit, they also resort to the help of lobelin, but take it in a shorter course.

Contraindications

1. Peptic ulcer of the stomach and duodenum;
2. Severe pathology of the cardiovascular system;
3. Pregnancy and lactation.

Side effects

Weakness, dizziness, nausea, vomiting, irritability.

Rep: Sol. Lobelini 1% - 1 ml
D.t.d.N. 5 in amp.
S. According to the scheme.

pharmachologic effect

Respiratory analeptic, tertiary amine. It has an n-cholinomimetic effect on the receptors of the carotid glomeruli and reflexively excites the respiratory center (and a number of other centers of the medulla oblongata). Due to the activation of the centers and ganglia of the vagus nerve, it first briefly reduces blood pressure, and then increases it mainly due to the stimulating effect on the sympathetic ganglia and the adrenal medulla. Works for a short time.
In high doses, lobelin excites the vomiting center, causes deep respiratory depression, tonic-clonic convulsions, and cardiac arrest.
The mechanism of action of lobeline, as a tool for quitting smoking, is apparently associated with competitive relationships in the area of ​​the same receptors and biochemical substrates with which nicotine interacts in the body.

Mode of application

For adults: When administered intravenously or intramuscularly for adults, a single dose is 3-5 mg, for children, depending on age, 1-3 mg.
Inside - as a means for weaning from smoking. The dose is set individually.

Indications

Reflex respiratory arrest mainly when inhaling irritants, or carbon monoxide poisoning; in the postoperative period.
- As an additional tool for smoking cessation.

Contraindications

Bleeding
- Pulmonary edema
- Severe organic lesions of the cardiovascular system
- Progressive exhaustion of the respiratory center
- Hypersensitivity to lobelin.

Side effects

With rapid administration: apnea, bradycardia, cardiac conduction disturbances.
- Ingestion: nausea, vomiting, tremor, dizziness, cough.

Release form

1% solution in ampoules and syringe-tubes of 1 ml.

ATTENTION!

The information on the page you are viewing was created for informational purposes only and does not promote self-treatment in any way. The resource is intended to familiarize healthcare professionals with additional information about certain medicines, thereby increasing their level of professionalism. The use of the drug lobelin"mandatory provides for a consultation with a specialist, as well as his recommendations on the method of application and dosage of the medicine you have chosen.

Analeptics are

bemegrid,

camphor

cordiamine,

etimizole, etc.

caffeine, which has a psychostimulant effect,

Lobelia, cytiton - drugs with a reflex mechanism of action, mainly stimulating the respiratory center due to the excitation of H-cholinergic receptors in the carotid sinus zone.

BEMEGRID- the most powerful analeptic. Bemegrid is used to stimulate respiration and blood circulation, to remove from the state of anesthesia, with an overdose of narcotic drugs; recommended for poisoning with barbiturates and other sleeping pills. The dosage of bemegrid is strictly individual, depending on the patient's condition.

Side effects of bemegrid: vomiting, convulsions. Bemegrid is contraindicated in patients with a tendency to convulsions.

Release form: 10 ml ampoules of 0.5 solution . List B.

Bemegrid recipe example:

Rp.: Sol. Bemegridi 0.5% 10ml

D.t. d. N. 10 ampull.

S. Administer 2-5 ml intravenously to non-anesthetized patients; 5-10 ml - at

poisoning with sleeping pills, for removal from anesthesia.

ETIMIZOL- has a pronounced stimulating effect on the respiratory center, is used as a respiratory stimulant (under anesthesia, etc.). Etimizol improves short-term memory, increases mental performance. Etimizol stimulates the pituitary-adrenal system, and therefore has an anti-inflammatory, anti-allergic effect. Etimizol is used for polyarthritis, bronchial asthma, etc. Accumulation of cAMP in tissues plays a role in the mechanism of action of etimizol.

Side effects of etimizole: nausea, dyspepsia, anxiety, sleep disturbances, dizziness. Etimizole is contraindicated in diseases accompanied by CNS excitation. Etimizol is administered orally and parenterally (intramuscularly, intravenously slowly).

Release form tablets of 0.1 g and ampoules of 3 ml of a 1.5% solution. List B.

Etymizole recipe example:

Rp.: Sol. Aethimizoli 1.5% 3ml

D.t. d. N. 10 ampull.

S. 3-5 ml intramuscularly.

Rep.: Tab. Aethimizoli 0.1 N. 50

D.S. 1 tablet 2-3 times a day.

CORDIAMINE- official 25% solution of nicotinic acid diethylamide, excites the respiratory and vasomotor centers. Cordiamin is used for heart failure (improves blood circulation), shock, asphyxia, poisoning, infectious diseases (to improve the function of the cardiovascular system and respiration). Cordiamin is prescribed orally and intravenously slowly (for poisoning, shock), subcutaneously, intramuscularly.

Release form: bottle of 15 ml and ampoules of 1 ml and 2 ml. List B.

An example of a cordiamine recipe:

Rp.: Cordiamini 15 ml

D.S. 20-25 drops 2-3 times a day.

Rp.: Cordiamini 1 ml

D.t. d. N. 10 ampull.

S. 1 ml subcutaneously 1-2 times a day.

MICOREN- has a powerful stimulating effect on the respiratory center in case of respiratory failure of central and peripheral origin. Mikoren is used for poisoning with drugs that depress the central nervous system (hypnotics, anesthetics, alcohol, etc.), asphyxia of newborns. Mikoren is administered intravenously 0.3-0.5 ml; in emergency cases (coma, respiratory arrest, poisoning) - 3-4 ml (maximum - 10 ml), and then, if necessary, administered at a rate of 3-9 ml / h in isotonic sodium chloride solution or dextran.

Side effects of mikoren: passing paresthesia, agitation, rarely - vomiting, convulsions.

Release form: ampoules of 1.5 ml of a 15% solution (containing 225 mg of mikoren). foreign drug.

CAMPHOR- stimulates the respiratory and vasomotor centers, and also acts directly on the heart, normalizing metabolic processes in the myocardium and increasing the sensitivity of the myocardium to the influence of sympathetic nerves and adrenaline. It is also possible that a reflex effect on the centers of the medulla oblongata due to the irritating effect of camphor. Camphor has a longer-lasting effect than previous preparations. Camphor is used for various infectious diseases, poisoning, accompanied by respiratory depression and the functions of the cardiovascular system, with arterial hypotension, collapse, in the complex therapy of acute and chronic heart failure. Side effects of camphor: embolism when an oily solution enters the lumen of the vessel, a skin reaction (rash), agitation, convulsions. Camphor is contraindicated in diseases characterized by CNS excitation, convulsions.

Release form: powder; ampoules of 1 ml and 2 ml of 20% oil solution; bottles of 30 ml of 10% camphor oil and bottles of 40 ml and 80 ml of camphor alcohol.

Camphor recipe example:

Rp.: Sol. Camphorae oleosae 20% pro injectionibus 2 ml

D.t. d. N. 10 ampull.

Rp.: Camphorae tritae 0.1 Rp.: Spiritus camphorati 80 ml

Sacchari 0.2 D.S. For grinding.

D.t. d. N. 10 in charta cerata.

S. 1 powder 3 times a day.

SULFOCAMFOCAINE- a complex compound of sulfocamphoric acid and novocaine. Sulfocamphocaine is used in acute heart and respiratory failure, it is similar in action to camphor. This drug (sulfocamphocaine) is not prescribed for hypersensitivity to novocaine and great care is taken when administered to patients with arterial hypotension (due to the possible hypotensive effect of novocaine). Sulfocamphocaine is administered intramuscularly, intravenously slowly and subcutaneously.

Release form: 2 ml ampoules of 10% solution.

An example of a sulfocamphocaine recipe:

Rp.: Sol. Sulfocamphocaini 10% 2ml

D.t. d. N. 10 ampull.

S. 2 ml under the skin 2-3 times a day.

Carbon dioxide- has a direct excitatory effect on the centers of the medulla oblongata and reflex - through the receptors of the synocorotid zone. Carbon dioxide is formed in the process of metabolism is a physiological stimulator of the respiratory center; stimulates the vasomotor center, causing constriction of peripheral vessels and increasing blood pressure. To stimulate breathing use a mixture of carbon dioxide (5-7%) and oxygen (93-95%), called carbogen. Carbogen is used for an overdose of anesthetics, carbon monoxide poisoning, neonatal asphyxia, etc. If there is no effect after 5-7 minutes from the start of inhalation with carbogen, then the introduction of carbon dioxide should be stopped, otherwise more severe respiratory depression may occur. Carbon dioxide is also used in balneology (in therapeutic baths) for diseases of the cardiovascular system, dermatology (treatment with "carbon dioxide snow" of warts, neurodermatitis, lupus erythematosus, etc.). Carbonated drinks containing carbon dioxide are used to enhance secretory activity and motility of the gastrointestinal tract.

N-cholinomimetics

1. LOBELINA HYDROCHLORIDE- used to stimulate breathing; activates H-cholinergic receptors of the carotid glomerulus, reflexively excites the respiratory center. Arterial pressure rises due to the excitation of H-cholinergic receptors of the adrenal medulla, sympathetic ganglia, which should be taken into account when administered to patients with arterial hypertension. Lobellin hydrochloride is used to a limited extent, mainly to stimulate respiration in case of carbon monoxide poisoning, inhalation of irritating substances, etc. Lobellin hydrochloride is administered intravenously slowly (1 ml in 1-2 minutes), less often - intramuscularly.

Release form: 1 ml ampoules of 1% solution. List B.

An example recipe for lobelline hydrochloride:

Rp.: Sol. Lobelini hydrochloridi 1% 1ml

D.t. d. N. 5 in amp.

S. Inject 0.3-0.5 ml intravenously (over 1 minute).

CYTITON- 0.15% solution of cytisine alkaloid. Cytiton stimulates reflexively the respiratory center, acting like lobelin hydrochloride. Cytiton increases blood pressure by stimulating the H-cholinergic receptors of the sympathetic ganglia and adrenal glands. Cytiton is used for reflex respiratory arrests that occurred during operations, injuries, collaptoid conditions, etc.

Cytiton is contraindicated in arterial hypertension, atherosclerosis (due to the ability to increase blood pressure).

Release form: 1 ml ampoules . List B.

An example of a cititone recipe:

Rp.: Cytitoni 1 ml

D.t. d. N. 10 ampull.

S. 1 ml intravenously.

COUGH MEDICINES

Cough is a complex reflex reaction of the airways, the main function of which is to restore their normal patency.

The occurrence of a cough may be due to irritation of the cough receptors of the nose, ears, posterior pharyngeal wall, trachea, bronchi, pleura, diaphragm, pericardium, esophagus. External and internal factors (foreign bodies, cold and dry air, air pollutants, tobacco smoke, nasal mucus, sputum, inflammation of the mucous membranes of the respiratory tract, etc.) excite cough receptors, which are divided into irritant receptors that quickly respond to mechanical, thermal, chemical irritants, and C-receptors, mainly stimulated by inflammatory mediators (prostaglandins, kinins, substance P, etc.). The resulting impulse is transmitted through the afferent fibers of the vagus nerve to the cough center located in the medulla oblongata. The reflex arc is closed by efferent fibers of the vagus, phrenic and spinal nerves going to the muscles of the chest, diaphragm and abdominal muscles, the contraction of which leads to the closure of the glottis, followed by its opening and expulsion with high air speed, which is manifested by coughing.

In addition, coughing can be induced or suppressed voluntarily, since the formation of the cough reflex is under the control of the cerebral cortex.

Cough is classified by nature (unproductive, or dry, and productive, or wet cough), by intensity (cough, mild and severe cough), by duration (episodic, paroxysmal and persistent cough), by course (acute - up to 3 weeks, protracted - more than 3 weeks and chronic - 3 months or more).

In some cases, cough loses its physiological expediency and not only does not contribute to the resolution of the pathological process in the respiratory system, but also leads to the development of complications.

The reflex arc of the cough reflex includes receptors, the cough center, afferent and efferent nerve fibers, and the executive link - the respiratory muscles. The most effective cough is suppressed at two levels - the receptor and the level of the cough center.

Due to this antitussive drugs are divided into 2 groups: central and peripheral action.

In its turn centrally acting drugs can be divided into narcotic and non-narcotic medicines.

CODEINE PHOSPHATE, CODEINE- in action it is close to morphine (that is, it is a narcotic drug of central action), but it inhibits the cough center more strongly. Codeine is used as an antitussive in severe cases. Codeine phosphate is combined with non-narcotic analgesics, sedatives.

Side effects of codeine: addiction and drug dependence ("codeinism"), constipation.

Contraindicated in general exhaustion (cachexia), respiratory failure, in old age and childhood (especially children under 3 years of age who are hypersensitive to the drug), nursing mothers (excreted in large quantities with milk), without emergency, all patients due to the development of drug dependence (drug addiction) .. Assign 0.01-0.03 g per reception.

Release form: powder, codeine phosphate is part of the combined tablets ("Kodterpin", "Cough tablets", "Sedalgin", "Pentalgin"), List B.

Sample recipe for codeine phosphate:

Rp.: Codeini 0.015

Natrii hydrocarbonatis 0.25

D.t. d. No. 6 in tab.

S. 1 tablet 2-3 times a day.

LIBEXIN( libexynum) - synthetic antitussive drug, the active substance is prenoxidiazine chloride. (Non-narcotic central action)

Release form. 100 mg tablets of 10, 20 and 100 tablets per pack.

Medicinal properties Libexin has antitussive, antispasmodic, anti-inflammatory and local anesthetic effects on the mucous membrane of the respiratory tract. In terms of activity, Libexin is approximately equal to codeine, but does not depress breathing and does not cause addiction.

Indications for use. Upper respiratory tract infections, acute and chronic bronchitis, bronchial tumors, the presence of a foreign body in the bronchial tumors, bronchial asthma, influenza, pulmonary emphysema, dry and exudative pleurisy, pleuropneumonia, pulmonary infarction, spontaneous pneumothorax; surgical interventions on the pleura; in the preparation of patients before bronchoscopy and bronchography; with night cough in patients with cardiovascular diseases in the stage of decompensation, etc.

Application rules. Libexin is taken orally, adults are prescribed 0.1 g (1 tablet) 2-3 times a day, in severe cases - 0.2 g (2 tablets) 3-4 times a day.

For children, the drug is prescribed depending on age and body weight - 0.025-0.050 g (1/4-1/2 tablets) per dose 3-4 times a day.

To avoid numbness of the oral mucosa, the tablets are swallowed without chewing.!

Side effects. Numbness and dryness of the mucous membrane of the mouth and throat, nausea, diarrhea, allergic reactions (skin rash, swelling, etc.).

Contraindications. Diseases that are accompanied by abundant sputum from the respiratory tract, especially in the postoperative period after inhalation anesthesia.

Pregnancy and lactation. During pregnancy and lactation, Libexin is used with great care.

Rp.: Libexyni 0.1

D.t. d. No. 20 in tabl.

Storage conditions. Store at 15-25°C. Shelf life 5 years.

GLAUCINE HYDROCHLORIDE( Glaucini hydrochloridum) Non-narcotic central action

Glaucine hydrochloride is a preparation from the herb machka yellow.

Release form. Tablets of 0.05 g, coated yellow, in a package of 20 pieces.

Description of medicinal properties. Glaucine has an antitussive effect, without inhibiting respiration and without disturbing bowel function. The drug moderately lowers blood pressure.

Indications for use. Glaucine hydrochloride is used for dry cough that occurs with bronchitis, pneumonia and other diseases of the respiratory organs. It is especially rational to use this drug to calm cough in patients with high blood pressure.

Tablets are taken orally after meals or 30 minutes before meals with a "/ glass of water. Assign 1 tablet 2-3 times a day. The drug is rapidly absorbed, the effect occurs after 3-5 minutes and lasts for several hours. The duration of treatment depends on the duration of the disease and the need to take the drug.

Side effects and complications. In some patients, when taking glaucine, dizziness and nausea may occur.

Contraindications. Glaucine hydrochloride should not be used for coughs accompanied by copious sputum production, and should not be given to patients with low blood pressure and myocardial infarction.

Storage. The drug should be stored in a dark dry place. Shelf life 1 year.

OXELADIN(OXELADIN) (non-narcotic central action)

Synonyms: Tusuprex

Pharmachologic effect. Antitussive agent of central action. It has a selective effect on the cough center. It has no chemical similarity to opioids or antihistamines. In therapeutic doses, it does not suppress the respiratory center, it helps to normalize breathing. Does not cause drowsiness. Does not affect intestinal motility.

Dosage. The average therapeutic dose for adults is 20 mg 3-4 times / day. Children aged 2-7 years - 5-10 mg 3 times / day, 8-18 years old - 10 mg 3-4 times / day.

Side effects. From the digestive system: nausea, vomiting, epigastric pain. From the side of the central nervous system: drowsiness, fatigue.

Indications. Cough of various origins, incl. with colds, infectious and allergic diseases of the respiratory tract; smokers cough.

Contraindications. Bronchospasm, bronchiectasis, bronchial asthma, bronchitis, accompanied by cough with sputum difficult to separate.

Special instructions. In children, it is used in exceptional cases and only with a dry cough.

Bronchial asthma - This is a disease that is manifested by asthma attacks resulting from bronchospasm. The cause of bronchial asthma is most often allergic reactions to various irritants (allergens).

Allergens can be some food substances (berries, mushrooms), pollen of certain flowers, industrial dust, etc. Sometimes the cause of an asthmatic attack cannot be established. To eliminate attacks of bronchial asthma or their prevention, substances of various groups are used.

1. stimulants of beta-adrenergic receptors: isadrine, adrenaline and ephedrine, salbutamol, fenoterol, etc.;

2. M-anticholinergics: drugs of the atropine group (methacin, atrovent.);

3. antispasmodics of myotropic action - papaverine, aminofillin, etc.;

4. antihistamine and antiallergic drugs - diphenhydramine, diprazine, cromolyn sodium, ketotifen, zaditen .;

5. glucocorticoids - hydrocortisone, prednisol, beclomethasone, budesonide, etc.;

6. drugs that affect the leukotriene system - zileuton, zafirluxate, monteluksat.

The drugs of the first three groups are used to eliminate (stop) attacks of bronchial asthma and prevent them (symptomatic therapy), drugs of the remaining groups - only to prevent attacks (basic therapy).

Thus, the elimination of an attack of bronchospasm can be achieved by excitation of adrenoreceptors or blockade of M-cholinergic receptors; as well as direct action on smooth muscles of antispasmodics

ISADRIN(Isadrinum) - beta2-agonist, has a strong bronchodilatory effect.

Indications for use. Isadrin is used to treat (stop and prevent attacks) bronchial asthma. The drug gives significant relief in mild to moderate attacks.

In chronic asthmatics, inhalation of Isadrin leads to liquefaction of sputum and its easier removal.

Isadrin is also used for asthmatic and emphysematous bronchitis, treatment of pneumosclerosis.

Application rules. Isadrin is most effective and causes the least side effects when used in the form of inhalation - inhalation in the form of aerosols of 0.5-1.0 ml (0.5% or 1.0% solution -25 ml) using a pocket inhaler. Izadrin inhalations can be made 2-4 times a day.

It is also prescribed in the form of tablets (0.005 for 20 pieces) for sublingual (under the tongue) use, ½-1-2 tablets 3-4 times a day (keep the tablets under the tongue until completely resorbed).

Parenterally administered 0.5-1.0 ml of 0.5% solution of Izadrin.

Side effects. palpitations, arrhythmia, dry throat, nausea, etc., requiring a reduction in the dose of the drug.

Contraindications. Severe atherosclerosis, arrhythmias and organic heart disease.

Recipe for Isadrine

Rp.: Isadrini 0.005

D.t. d. No. 20 in tabl.

Composition and form of release. Release: 0.5% solution of izadrin in vials of 10 ml and 25 ml; tablets of 0.005 g for sublingual use, in a package of 20 tablets., 0.5% solution in ampoules of 1 ml in a package of 5 pieces

Store in a dry place protected from light.

Shelf life of Isadrin: tablets - 4 years, solution - 5 years, ampoules and aerosol - 2 years.

Salbutamol- selective agonist of β2-adrenergic receptors. Stimulates predominantly β2-adrenergic receptors, localized in the bronchi, myometrium, blood vessels. When administered by inhalation, it acts mainly on β2-adrenergic receptors of the bronchi, having little effect on β2-adrenergic receptors of other localizations. It has a pronounced bronchodilator effect.

Causing the expansion of the bronchi, stops and prevents bronchospasm. Virtually no effect on β1-adrenergic receptors of the heart. Prevents the release of allergy and inflammation mediators (histamine, SRSA) from mast cells. Improves mucociliary clearance.

The effect of the drug develops quickly and lasts 3-4 hours. After inhalation, approximately 10-20% of the active substance reaches the small bronchi, the rest settles in the upper respiratory tract. Plasma protein binding is 10%. Salbutamol is metabolized in the liver. It is excreted mainly in the urine unchanged and as an inactive metabolite. Most of the dose of salbutamol administered by inhalation or taken orally is eliminated within 72 hours.

Release form. Aerosol for inhalation, dosed, 100 mcg / dose, 200 doses in bottles No. 1. Tablets of 2 mg No. 30 (15x2) in blisters; 4 mg No. 30 in vials

ADRENALIN- a hormone derived from the cortical substance of the adrenal glands of cattle, as well as synthetically.

It is a non-selective adrenomimetic. Used to relieve asthma attacks.

Contraindicated in hypertension, vascular sclerosis, coronary insufficiency.

Release form 10 ml bottles of 0.1% solution for external use, 1 ml ampoules of 0.1% solution for parenteral administration.

In an asthma attack, enter: s / to adults 0.25 mg (2.5 ml of a diluted solution: 1 ampoule is diluted with 10 ml of a 0.9% sodium chloride solution); children weighing more than 10 kg - in / in slowly 0.1-0.3 mg (1-3 ml of a diluted solution).

Storage conditions

List B.: In a cool, dark place. Refrigerate if possible.

EPHEDRINE HYDROCHLORIDE- hydrochloride of the alkaloid ephedrine, obtained from the stems of various types of ephedra (Ephedra). The racemate of ephedrine is obtained synthetically.

Medicinal properties.Ephedrine, like adrenaline, constricts blood vessels, increases blood pressure, enhances the work of the heart, relaxes bronchial muscles , reduces intestinal peristalsis, dilates pupils, increases blood sugar levels.

In addition, ephedrine excites the central nervous system, increases the excitability of the respiratory center, enhances the tone and contractile properties of skeletal muscles.

Compared with adrenaline, the effect of ephedrine is weaker, develops less abruptly and is longer (lasts 7–10 times longer).

Indications for use

Ephedrine is used to prevent and treat attacks of bronchial asthma and whooping cough in combination with antispastic (Eufillin, Tifen, Papaverine) and sedatives,

As a means of stimulating the central nervous system, in particular the respiratory center, ephedrine hydrochloride is used for poisoning with drugs and hypnotics (barbiturates, morphine).

With an overdose of ephedrine, anorexia, nausea, vomiting, difficulty urinating, nervous excitement, muscle trembling, insomnia, dizziness, increased sweating, tachycardia are observed. Many of these phenomena are removed by barbiturates.

Contraindications for use

Insomnia, severe arterial hypertension, angina pectoris, pronounced atherosclerosis, hyperthyroidism. Special care is needed in the appointment of ephedrine hydrochloride in organic heart disease with symptoms of decompensation.

special instructions

Reception of ephedrine in order to avoid sleep disturbances is best done in the morning.

Composition and form of release

Tablets for children, 0.01 g, 10 tablets per pack;

5% solution of ephedrine hydrochloride in 1 ml ampoules, in packs of 10 and 100 ampoules.

Shelf life and storage conditions. Store in a well-closed container, protected from light. List B

Shelf life of ephedrine hydrochloride: tablets - 3 years, solutions of 2% and 3% - 3 years, 5% solution for injection in ampoules - 5 years, 5% solution in syringe tubes - 2 years.

The drug is released from pharmacies strictly by prescription.

Eufillin- combined synthetic preparation of theophylline with 1,2-ethylenediamine.

Medicinal properties

Eufillin has antispasmodic, vasodilating and bronchodilatory action. (relieves spasm of smooth muscles of the bronchi)

Eufillin excites the respiratory and vasomotor centers, increases the frequency and strength of heart contractions, its minute volume and blood circulation, improves hemodynamics, including in the pulmonary circulation, has a relaxing effect on the smooth muscles of the bronchi, biliary tract, gastrointestinal tract..

According to the pharmacological action, Eufillin is close to Theophylline.

Indications for the use of the drug Eufillin

Bronchial asthma, cardiac asthma, angina pectoris and other cardiovascular diseases accompanied by congestion, pulmonary edema, hypertensive crises, ischemic conditions of the brain, stroke in the initial stage, as a diuretic.

Application rules Inside, Eufillin is prescribed in capsules and tablets, 0.1-0.2 g 2-3 times a day after meals.

Intramuscularly injected 2-3 ml of a 12% solution of aminophylline or 1.0-1.5 ml of a 24% solution of aminophylline.

Intravenously (inject slowly) - 5–10 ml of a 2.4% solution of eufillin, the contents of the ampoule are dissolved in 10–20 ml of a 40% glucose solution.

Rectally in suppositories (suppositories containing 0.2–0.4 g of aminophylline are injected into the anus 1 suppository 2 times a day) or microclysters of 0.2–0.4 g of the drug.

Higher doses of Eufillin inside, intramuscularly and rectally: single - 0.5 g; daily - 1.5 g.

The highest dose of the drug intravenously: single - 0.25 g; daily - 0.50 g.

Side effects Anxiety, sleep disturbances, hand tremors.

Taking Eufillin inside can cause dyspeptic symptoms (nausea, vomiting, diarrhea); with rapid intravenous administration - dizziness, headache, palpitations, nausea, vomiting, convulsions, hypotension (drop in blood pressure); with rectal application - irritation of the intestinal mucosa.

Contraindications to the use of Eufillin

Acute period of myocardial infarction, infarction with collapse phenomena, severe coronary spasm, severe coronary sclerosis, paroxysmal tachycardia, extrasystole, hypertension, tachyarrhythmia; hyperthyroidism; epilepsy; peptic ulcer of the stomach and duodenum; severe liver dysfunction; children's age (up to 6 years); increased individual sensitivity to the drug.

Pregnancy and lactation

During pregnancy and lactation, the use of Eufillin is possible only for extreme indications.

Smoking can safely be called a disease of society. According to statistics, every third person on the planet has this addiction. Nicotine is the main substance harmful to the body of tobacco causes enormous damage to health. To help kick this habit, Lobeline was developed. It is an effective substitute for nicotine, while it has the same properties. The main characteristic of the drug is the absence of harm to health.

Release form action

Lobeline hydrochloride is a substance extracted from the leaves of Indian tobacco. Its main advantage is its effect on the stimulation of the respiratory center.

As the instruction describes, the pharmacokinetics of the process affects arousal:

• chemoreceptors in the carotid sinus zone;
• n-cholinergic receptors of autonomic ganglia;
• adrenals.

The action taken is short-lived. Its synonyms for the name are cytiton, "Lobesil".

Indications

Lobelin, also known as cytisine, is prescribed for use in violation of the respiratory function. The action of the compound is aimed primarily at eliminating the consequences of the inhibitory factor. A group of certain pathogens, the mechanism of action of which on the brain centers causes breath holding, causing dire consequences.

Lobelin is prescribed when it appears:

• severe form of breath holding;
• recovery period after surgery;
• asphyxia in newborns;
• side effects of smoking.

Application methods

The pharmacological form of lobelin hydrochloride has several ways of application depending on
forms of matter. The solution is administered intravenously, the mechanism of administration depends on the severity of the disease.

These can be droppers or single injections. The substance must be administered slowly over an extended period. It is prescribed in the fight against the effects of smoking.

The use of tablets depends on the form of the disease. The number and frequency of admission is prescribed individually. The dose calculation is based on the proportions of the patient's age.

Doses

The use of the substance lobelin in liquid form is calculated individually, based on:

• body weight of the patient;
• age;
• the degree of damage to the functioning of the respiratory center.

Pharmacodynamics of the liquid form acts for a short time. As the instructions describe, the average daily dose of a cytiton solution for an adult is:

• minimum - 0.3 ml;
• medium - 0.5-0.10 ml;
• maximum - 0.20 ml.

For children over 5 years of age:

• minimum - 0.1 ml;
• maximum - 0.3 ml.

Form in tablets for an adult:

• minimum -3 mg;
• average - 5 mg;
• maximum -20 mg.

The child is prescribed doses:

• minimum -1 mg;
• maximum -3 mg.

Form

Lobelin is available in two easy-to-use forms. Each of which has its own advantages.
The form of the chemical substance cytiton is:

• ampoules of a liquid substance;
• Lobesil tablets.

The drug contains 2% of the substance lobeline hydrochloride. As the instructions describe, each ampoule contains a solution with a concentration of 1%. The package contains 10 ampoules and instructions for use.

Tablets "Lobesil" are packaged in a standard pack of 50 pieces. Tablets are convenient for everyday use in the fight against the effects of smoking.

Contraindications

In some diseases, the active substances that lobelin contains can trigger the reverse mechanism of inhibition of certain body functions. The list of these contraindications includes:

• hypersensitivity to the substance lobelin hydrochloride;
• pulmonary edema;
• deep damage to the cardiovascular system;
• bleeding;
• progressive exhaustion of the respiratory center.

Before using cytisine, it is necessary to check the release date, since an expired drug has a detrimental effect.

Side effects

If the dose is exceeded, the drug may cause some side effects:

Cytisine can have such an effect if it is introduced into the blood too quickly. Some indications for taking the tablet form can cause:

• choking cough;
• severe nausea;
• tremor of the limbs;
• profuse vomiting;
• dizziness.

Extreme forms of lobeline resistance can lead to:

• cardiac arrest;
• cause severe convulsions;
• stimulate myocardial conduction disturbance.

Prices

The drug can be purchased at pharmacies in the city. This requires a prescription from the attending physician for a specific pharmacological form. The average price for lobelin in pharmacy warehouses is:

• tablets from 174.63 rubles.
• ampoules from 2632.91 rubles.

You can buy the drug Lobeline via the Internet through the order form on the relevant distributor sites. The cost of the required substance is:

• tablets from 176.09 rubles.
• ampoules from 396.62 rubles.

When purchasing through Internet portals, specify the year of manufacture, the country of manufacture. The latter affects the quality of the drug.

Properties

Indications of a weakening of breathing or its complete stop may be one of the reasons for refusing to prescribe the drug. Especially if it is provoked by progressive depletion of the respiratory centers of the brain. In such cases, the action of the drug may cause additional inhibition of respiratory functions. The interaction of the active substances of the drug with some antibiotic agents is undesirable.

Best before date

According to the indication from the manufacturer, depending on the pharmacological form, lobelin can be stored for different periods of time. The form of storage can also affect the expiration date. Violation of the instructions may lead to loss of the effect of the drug. You can find out the correct storage conditions by studying the attached prescription insert.

The specified periods for the storage of ampoules state that the liquid solution of the drug retains its properties for 5 years. Tablets with the same content of the substance are suitable for exactly 1 year after release. Before you buy a drug, carefully read the date line.