Medicinal reference book geotar. Sulfadimethoxine: what this antibiotic helps with, how often to use it, analogues
Sulfadimethoxine- a broad-spectrum antibacterial agent with a bacteriostatic effect.
Sulfadimethoxine, being chemically analogous to para-aminobenzoic acid, prevents its absorption and disrupts biosynthetic processes in bacterial cells. It inhibits the growth and reproduction of gram-positive and gram-negative bacteria, including anaerobes. Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae); gram-negative bacteria: Klebsiella pneumoniae, Escherichia coli, Shigella spp. Active against Chlamydia trachomatis.
The antimicrobial effect of sulfadimethoxine is significantly weakened in the presence of pus and tissue decay products.
Pharmacokinetics
.When taken orally, it is relatively slowly absorbed from the gastrointestinal tract; in the blood is detected after 30 minutes. The maximum concentration in the blood is reached after 8-12 hours. The required therapeutic concentration in the blood (in adults) when taking 1-2 g is noted on the first day, maintenance doses (0.5-1 g) provide a therapeutic level in the blood throughout the course of treatment .
It penetrates well into tissues and body fluids, including pleural effusion, peritoneal and synovial fluids, middle ear exudate, chamber moisture, and tissues of the genitourinary tract. Penetrates through the placenta and into breast milk. Poorly penetrates the blood-brain barrier.
Metabolism is carried out mainly in the liver by microsomal glucuronidation. It is excreted in the form of metabolites, mainly by the kidneys, and also with bile.
Indications for use
A drug Sulfadimethoxine used to treat infectious and inflammatory diseases caused by microorganisms sensitive to sulfadimethoxin: respiratory tract and ENT organs (tonsillitis, bronchitis, pneumonia, otitis media, sinusitis), biliary and urinary tract, meningitis, shigellosis, wound infection, pyoderma, gonorrhea, trachoma , erysipelas, toxoplasmosis; resistant forms of malaria (in combination with antimalarial drugs).Mode of application
Sulfadimethoxine administered orally after meals, 1 time per day with an interval between doses of 24 hours.Adults are prescribed:
- for mild infections - on the first day, 1 g (2 tablets), on subsequent days -
0.5 g (1 tablet);
- for moderate and severe infections - on the first day, 2 g (4 tablets), on the following days - 1 g (2 tablets). If necessary, the dose may be increased.
Children under 12 years of age are prescribed: on the first day, 25 mg / kg, on subsequent days, 12.5 mg / kg; children over 12 years old - on the 1st day, 1 g (2 tablets), on the following days - 0.5 g each
(1 tablet).
The duration of the course of treatment depends on the severity of the disease and is 7-10 days.
Treatment must necessarily continue for 2-3 days after the normalization of body temperature.
Side effects
From the nervous system: headache.From the digestive system: dyspepsia, nausea, vomiting, cholestatic hepatitis.
Allergic reactions: skin rash, drug fever.
From the hemopoietic system: rarely - leukopenia, agranulocytosis.
Contraindications
Contraindications to the use of the drug Sulfadimethoxine are: hypersensitivity to sulfonamides and other components of the drug, inhibition of bone marrow hematopoiesis, renal and / or liver failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation, children under 2 months of age.Pregnancy
During drug treatment Sulfadimethoxine breastfeeding should be discontinued, as the drug passes into breast milk and can cause kernicterus in children, as well as hemolytic anemia in children with glucose-6-phosphate dehydrogenase deficiency.Interaction with other drugs
Sulfadimethoxine reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins). Antibacterial activity is reduced by procaine, benzocaine and tetracaine, and enhanced by barbiturates and para-aminosalicylic acid. Methotrexate and phenytoin increase the toxicity of sulfadimethoxine; non-steroidal anti-inflammatory drugs, thioacetazone, chloramphenicol, myelotoxic drugs increase the toxic effect on the blood. Sulfadimethoxine enhances the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action; reduces the effectiveness of oral contraceptives. Pyrazolone derivatives, indomethacin and salicylates increase the free fraction of sulfadimethoxine in the blood.Overdose
:Possible aggravation of side effects.
Treatment is symptomatic.
Storage conditions
To store in the place protected from light at a temperature from 8 °C to 25 °C. Keep out of the reach of children.Shelf life - 5 years.
Release form
Sulfadimetoksin - tablets.10 tablets in a blister pack and in a pack; 10 tablets in a blister pack.
Compound:
1 tablet Sulfadimethoxine contains sulfadimethoxine 0.5 g.
Excipients: sodium starch glycolate, pregelatinized starch, calcium stearate.
Additionally
Application of the drug Sulfadimethoxine in children under the age of 2 months is possible only for the treatment of congenital toxoplasmosis for health reasons.The limitation to the medical use of the drug is chronic heart failure.
Prescribing the drug to patients over 65 years of age should be avoided due to an increased risk of developing severe side effects.
During the course of treatment, it is necessary to systematically monitor the state of kidney function and the picture of peripheral blood.
During therapy, a large amount of alkaline drinking is recommended, sufficient to maintain diuresis at a level of at least 1.2 l / day for adults.
During treatment with the drug, it is necessary to observe the dosing regimen, take the prescribed dose after 24 hours, do not skip the dose. If you miss a dose, take it as soon as possible; do not take if it is almost time for the next dose; do not double the dose. It is recommended to avoid exposure to direct sunlight and ultraviolet radiation.
There are no data on the effect of the drug on the ability to drive vehicles and on the performance of potentially hazardous activities.
Main settings
| Name: | SULFADIMETOXINE |
| ATX code: | J01ED01 - |
Composition per tablet:
active substance: sulfadimethoxine -500 mg;
excipients: microcrystalline cellulose - 42.0 mg, crospovidone - 26.5 mg, povidone (medium molecular weight polyvinylpyrrolidone, povidone K-25) - 25.5 mg. calcium stearate - 6.0 mg.
Description: Round flat-cylindrical tablets of white or white color with a creamy tinge with a chamfer and a risk mark. Pharmacotherapeutic group:Antimicrobial agent, sulfanilamide. ATX:J.01.E.D Long acting sulfonamides
Pharmacodynamics:Antimicrobial bacteriostatic agent. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthetase, impaired synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative microorganisms: Staphylococcus spp., Streptococcus spp., incl. Streptococcus pneumoniae, Friedlander's bacilli, Escherichia coli, Shigella spp., Chlamydia trachomatis.
Sulfadimetoksin does not affect strains of bacteria resistant to sulfonamides.
Pharmacokinetics:When taken orally, it is absorbed relatively slowly, found in the blood after 30 minutes. With a single dose (at a dose of 1-2 g), the time to reach the maximum concentration in the blood (Tmax) is 8-12 hours.
Therapeutic concentration in adults is achieved when taking 1-2 g on day 1 and 0.5-1 g on the following days. Communication with blood proteins - 90-99%.
The drug accumulates in the blood, primarily due to the high degree of binding to blood proteins (90-99%). It is well distributed among organs and systems. But unlike other representatives of long-acting sulfonamides, it penetrates poorly through the blood-brain barrier (BBB) and its concentration in the cerebrospinal fluid is low. However, with inflammation of the meningeal membranes, the permeability of the BBB increases dramatically. It penetrates well into the pleural fluid (60-90% of the concentration in the blood), into the biliary system, where its concentration is 1.5-4 times higher than in the blood.
Preferential metabolism is carried out along the path of microsomal glucuronidation associated with cytochrome P450 and NADPH-dependent.
A strong connection with blood plasma proteins and high reabsorption in the tubules of the kidneys (93-97.5%) contributes to the slow removal of the drug from the body. The blood contains 5-15% acetylated metabolites, the urine contains 10-25% acetyl derivatives and 75-90% sulfadimethoxine glucuronide; the latter is highly soluble and does not provoke the development of crystalluria. The acetyl derivative is not reabsorbed and is completely excreted by the kidneys. After 24 hours, 20-40% of the dose taken is excreted, after 48 hours - up to 56%, after 96 hours - up to 83.3%.
Indications: Diseases caused by sensitive microflora: tonsillitis, otitis media, sinusitis; bronchitis, pneumonia; dysentery; pyoderma; erysipelas; trachoma; wound infections; gonorrhea; diseases of the urinary and biliary tract; malaria (as part of complex therapy). Contraindications:Hypersensitivity to sulfadimethoxine or other components of the drug; inhibition of bone marrow hematopoiesis; renal / liver failure, chronic heart failure, congenital deficiency of glucose-6-phosphate dehydrogenase; porphyria; azotemia;
pregnancy and breastfeeding, children under 12 years of age (for this dosage form and dosage).
Pregnancy and lactation:The use of the drug during pregnancy and during breastfeeding is contraindicated. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
Dosage and administration:Inside, 1 time per day. Adults, on the 1st day - 1-2 g, then - 0.5-1 g / day.
For children from 12 to 18 years old: the initial and maintenance doses are 1 g and 0.5 g, respectively.
is 7-14 days.
Side effects:allergic reactions; headache, dyspepsia, leukopenia, agranulocytosis, cholestatic hepatitis. Interaction:The action of sulfadimethoxine is enhanced when combined with diaminopyrimidine derivatives (trimethoprim, tetroxoprim,).
Reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins). increases the risk of developing toxic reactions.
Methotrexate and other folic acid antagonists increase the risk of folic acid deficiency.
Procaine and tetracaine reduce antibacterial activity. PAS and barbiturates increase the antimicrobial effect. Salicylates increase the activity and toxicity of sulfadimethoxine. contributes to the development of photosensitivity. Non-hormonal anti-inflammatory drugs increase the toxic effect on the blood (leukopenia, agranulocytosis).
Enhances the effect of indirect anticoagulants, phenytoin, sulfonamides with hypoglycemic action;
Reduces the effectiveness of oral contraceptives. Enhances the metabolism of cyclosporine.
Special instructions:During therapy, it is recommended to drink plenty of fluids, regular monitoring of blood and urine parameters. Influence on the ability to drive transport. cf. and fur.:During the period of treatment, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.Latin name: Sulfadimethoxinum
ATX code: J01ED01
Active substance: Sulfadimethoxine
Manufacturer: Darnitsa CJSC, Ukraine
Pharmacy leave condition: Over the counter
The composition of the drug
One tablet contains five hundred milligrams of sulfadimethoxine in terms of one hundred percent of the dry matter. Aerosil, gelatin, calcium stearate, potato starch are present as additives to the active ingredient in the composition.
Medicinal properties
Sulfadimethoxine is an antibacterial drug with a pronounced long-term effect. This antibiotic has proven effective against both gram-negative and gram-positive microorganisms, such as staphylococci, klebsiella, streptococci, salmonella, toxoplasma, shigella, malarial plasmodia, some chlamydia, including Chlamydophila trachomatis, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae. The absorption of the active substance by the gastrointestinal tract is relatively slow. You can detect a substance in the blood after thirty minutes. The maximum concentration is reached after eight to twelve hours. The therapeutic concentration necessary for an adult occurs when one or two grams of the substance is taken on the first day, and half a gram or one gram on the next. Bioavailability is from seventy to one hundred percent. The half-life of the antibiotic is forty hours. Excretion from the body is carried out mainly by the kidneys, partly with bile.
Indications for use
Sulfadimetoksin helps with uncomplicated inflammatory diseases of the biliary and urinary tract, dysentery. It is also used for trachoma, erysipelas, wound infection, otitis (read more about purulent otitis in the article :), tonsillitis and sinusitis, bronchitis, pyoderma, gonorrhea, pneumonia, toxoplasmosis, malaria, cholecystitis, beshikha.
Release form
Average price - 40 rubles
Sulfadimetoksin is a white or yellowish-cream in color tablets, odorless, round in shape, with a flat surface and a dash on one side.
Mode of application
Sulfadimetoksin is taken every day, on the first day a dosage of one to two grams is usually prescribed, and on the following days from half a gram to one gram.
For children, this antibiotic is prescribed twenty-five milligrams on the first day and twelve and a half milligrams on the next.
The duration of treatment is as long as prescribed by the attending physician, but usually the course of antibiotic treatment lasts no more than ten days and is accompanied by the use of probiotics to restore the intestinal microflora.
During pregnancy and breastfeeding
Sulfadimetoksin crosses the placental barrier and is excreted in breast milk. For this reason, the antibiotic is not prescribed for pregnant and breastfeeding women.
Contraindications
The main contraindication to the use of Sulfadimethoxine is hypersensitivity to the components. You should not drink the drug for severe dermatitis, hepatitis, drug-induced fever, porphyria, as well as lactating and pregnant women.
Precautionary measures
Especially carefully, the drug is prescribed to those categories of patients in whom the functioning of the liver and kidneys is impaired, as well as to patients with chronic heart failure and diseases of the circulatory system.
Interaction with other drugs
The drug tends to reduce the effectiveness of such bactericidal antibiotics that act exclusively on dividing microorganisms, such as cephalosporins and penicillins.
When combined with sulfadimethoxine with barbiturate drugs, its activity increases, and with salicylates, the toxic effect of the drug increases, as well as when combined with methotrexate and diphenin. And when combined with streptomycin, monomycin, kanamycin, the antibacterial effect will not change. When sulfadimethoxine is combined with nalidixic acid, with chloramphenicol, nitrofurans, a decrease in the overall therapeutic effect may be observed.
Side effects
As side effects, there are such as allergies in the form of urticaria, bronchospasm, hyperemia, swelling of the tongue and upper lip, angioedema, Lyell's and Steven-Jones syndromes. As well as photodermatosis, anaphylactic shock and others. Common nausea and vomiting, cholestatic hepatitis, dyspepsia, agranulocytosis, fever, headache and leukopenia, pancreatitis, dry mouth, diarrhea, jaundice, hepatic encephalopathy, syncope, aseptic meningitis, increased intracranial pressure, depression, optic neuropathy, psychosis, insomnia , myocarditis, fibrosing alveolitis, periarteritis nodosa, urine staining dark yellow, tubular necrosis, hypothyroidism, hypoglycemia, thrombocytopenia, hemolytic anemia, hypothrombanemia.
Overdose
There is no information about cases of overdose.
Terms and conditions of storage
The drug must be stored away from light sources, in a dark place. It is also recommended to hide the tablets out of the reach of children. The medicine can be stored for up to 5 years. It is not recommended to use the drug after the expiration of this period. The date of manufacture must be seen on the packaging of the drug. If the storage conditions are not observed, there is no effectiveness from its reception.
Analogues
NizhPharm, Russia
Price— 79 rubles
The composition includes: Dioxomethyltetrahydropyrimidine + Sulfadimethoxin + Trimecaine + Chloramphenicol, ointment in an aluminum tube.
Pros:
- Possibility of topical application of the antibiotic directly to damaged necrotic tissues with minimal negative impact on the liver and intestines due to less absorption into the blood.
- Higher efficacy in skin lesions when using a local remedy in the form of an ointment than in the form of tablets.
- You do not need a doctor's prescription to buy this medicine.
Minuses:
- Cons - only for external use.
- Due to the decrease in the effectiveness of the antibiotic after prolonged use, it is not recommended to use it for more than the number of days prescribed by the therapist.
Antibacterial drugs are used in most cases of diseases caused by microorganisms. Increasingly, attending physicians prescribe the remedy "Sulfadimetoksin". Many specialists and patients are confident in its effectiveness. What you need to know about the drug "Sulfadimetoksin"? The price of the drug, indications for its use, possible side effects. Some are interested in the existence of analogues. Others are interested in something else about the drug "Sulfadimetoksin": is it an antibiotic or not? All these details will be discussed next.
Release form
There is a single dosage form in which "Sulfadimetoksin" is produced. Reviews show that buyers especially appreciate that it is incredibly convenient to use. The drug is a tablet (yellowish-cream or white). The agent in question does not have a pronounced characteristic odor. The shape of the tablets is round.
Medicinal properties
Means "Sulfadimetoksin" is an antibiotic or not? The instructions say yes. The drug in question belongs to the group of antibacterial agents with a long pronounced effect. Many people prefer the antibiotic "Sulfadimetoksin" to all other drugs in this group. Reviews confirm that it consistently proves its effectiveness against a variety of microorganisms, both gram-positive and gram-negative. These include shigella, staphylococcus, salmonella, klebsiella, streptococcus, toxoplasma, and some types of chlamydia.
The absorption of the active substance in the gastrointestinal tract is carried out for a relatively long time. But the drug enters the blood after half an hour. And its maximum concentration is reached only after eight to twelve hours. Adults are advised to observe the concentration of the drug in the blood in an amount of one to two grams after the first day of treatment and in the amount of half a gram to one gram during the subsequent treatment time. The bioavailability of the substance in question is from seventy to one hundred percent. While the half-life of this drug is at least forty hours. In part, the substance is excreted from the patient's body with the help of the kidneys, and in part - along with bile. This is exactly the action of "Sulfadimethoxin".
Indications for use
It is important to understand how to use the drug correctly. What in this regard should you know about the drug "Sulfadimetoksin"? Reviews report that in the matter of indications for use, it is important to carefully follow the instructions. So, it is appropriate to use the drug in question only in the following cases: for dysentery, inflammation of the biliary tract, trachoma, inflammation of the urinary tract, otitis media, erysipelas, wound infection, pyoderma, tonsillitis, gonorrhea, sinusitis, beshikha, malaria, pneumonia, toxoplasmosis, cholecystitis.
How much will you have to spend on Sulfadimethoxin? The price of the drug in question is more than democratic. So, for tablets of two hundred milligrams, it will be necessary to pay up to forty rubles, for tablets of five hundred milligrams - up to fifty-five rubles.
How to take "Sulfadimetoksin"?
This drug is used daily (one or two grams on the first day and half a gram to one gram before). The dose for a child is a quarter of the adult dosage. The duration of therapy should be adjusted by a specialist. It is necessary to take probiotics at the same time, which will help restore the patient's natural intestinal microflora.
Contraindications to the use of the drug in question are:
- pregnancy;
- breastfeeding period;
- individual sensitivity to individual components of the drug;
- hepatitis;
- porphyria;
- severe dermatitis;
- drug fever;
- serious violations of the functioning of the kidneys or liver.
No cases of overdose have been recorded. However, you should not arbitrarily change the amount of medication prescribed by your doctor.
"Sulfadimetoksin": analogues
Among the drugs that could replace the agent in question, the following are distinguished:
- "Bactrim".
- "Aregdin".
- "Bactrim forte".
- "Dapson Fatol".
- "Argosulfan".
- "Groseptol".
- "Berlocid".
- "Duo Septol".
- Sulgin.
- "Biseptol".
- "Ftalazol".
- Briefeseptol.
- "Ingalipt".
- "Lidaprim".
- "Trimezol".
- "Etazol".
- "Dermazin".
- Cotripharm.
- "Septrin".
- "Dvaseptol".
- "Streptocide".
- "Sinersul".
- Streptocid soluble.
- "Ciplin".
- "Streptonitol".
- Oriprim.
- "Co-trimoxazole".
- "Sumetrolim".
- "Halfseptol".
- Sulgin.
- "Methosulfabol".
- "Sulfalene".
- "Albucid".
- "Sulothrim".
- Phthalylsulfathiazole.
- "Sulfadimezin".
- Sulfargin.
- "Sulfasalazine".
- "Sulfamethoxazole".
- "Sulfanilamide".
- "Sulfacetamide".
Let's take a closer look at two other popular analogues. One of them is Argedin. It is usually used to combat pressure sores, ulcers, and infectious skin lesions. Indications for its use are also the following conditions:
- deep contamination of wounds;
- skin transplantation;
- infected burns;
- superficial wounds with weak exudation.
Use this drug once or twice a day. In especially acute cases, it is recommended to use the drug four times a day.
The duration of the course should be adjusted by the attending physician, but cannot exceed two months.
Another analogue is Levosin. Its main components are sulfadimethoxine, dioxomethyltetrahydropyrimidine, chloramphenicol and trimecaine. The tool is an ointment in an aluminum tube.
What are its advantages? Higher efficiency than when using tablets. It is released from pharmacies without a prescription. Apply topically, directly to the affected areas of the skin.
However, there are also some disadvantages. For example, the medicine is intended exclusively for external use. With use, the effectiveness of the drug decreases.
These drugs can effectively replace "Sulfadimetoksin"? Analogues of this medication are actively used by specialists. They deserve some attention.
Side effects
What adverse reactions are possible when using the drug "Sulfadimetoksin"? Reviews warn of the possibility of some unpleasant manifestations. Side effects include swelling of the tongue, urticaria, hyperemia, bronchospasm, swelling of the upper lip, Steven-Jones syndrome, nausea, Quincke's edema, photodermatosis, Lyell's syndrome, anaphylactic shock, vomiting, diarrhea, psychosis, myocarditis, cholestatic hepatitis, fever, anaphylactic shock , thrombocytopenia, hypothrombanemia, dark yellow urine, dyspepsia, pancreatitis, jaundice, optic neuropathy, hypothyroidism, agranulocytosis, dry mouth, tubular necrosis, insomnia, syncope, hemolytic anemia, fever, aseptic meningitis, hypoglycemia, headache, depression, leukopenia, hepatic encephalopathy, fibrosing alveolitis, diarrhea, and increased intracranial pressure.
Interaction with other drugs
The patient should be carefully examined before starting to take on the application. Tablets significantly reduce the effectiveness of some other bactericidal antibiotics. We are talking only about those drugs, the action of which applies exclusively to dividing microorganisms (for example, penicillins and cephalosporins).
In cases where the drug is taken simultaneously with any barbiturate drugs, this kind of combination significantly increases its activity, while the combination with salicylates provokes an increase in the toxic properties of the substance. The same effect is caused by the interaction of the drug in question with difenin and methotrexate. No adjustments to the treatment regimen with the parallel use of monomycin, streptomycin and kanamycin will not be required.
It is forbidden to use the drug in question simultaneously with substances such as urotropin, difenin, antidiabetic drugs, neodicoumarin and other anticoagulants.
Terms and conditions of storage
In order for the drug in question not to lose its beneficial properties, it is important to store it in suitable conditions that would not allow it to deteriorate. Keep the medicine in a place where children do not have access. You can store the tool in question for no more than five years. After that, it is not recommended to take it. It may even be somewhat dangerous for the patient. Therefore, when buying, pay attention to the date of manufacture of the drug, which can be found on the package. Following this simple rule will help make the treatment more effective.
It is important to comply with the conditions of use prescribed for the drug Tablets should be used only in the manner recommended by the attending physician. In this case, the therapy will be most effective.
"Sulfadimetoksin" is used for infectious and inflammatory diseases caused by microorganisms sensitive to it. It is prescribed for the treatment of tonsillitis, otitis, dysentery, erysipelas, trachoma, sinusitis. The medicine is used, inflammatory diseases of the urinary and biliary tract, wound infections. Other indications for the appointment of "Sulfadimethoxin" are: purulent infections, sepsis, infectious diseases of the intestine (enterocolitis, dysentery, etc.), purulent diseases of the biliary tract.
It is also used for infectious eczema, urinary tract infections (gonorrhea, etc.), skin diseases (furunculosis, erysipelas, pyoderma, inflammation of the sebaceous glands), inflammatory lesions of the central nervous system, trachoma, malaria (in combination with antimalarial drugs). Analogues of "Sulfadimethoxin" are: "Sulfalen", "Sulfapiridazine", "Sulfalen-meglumine".
How to use "Sulfadimetoksin"
"Sulfadimetoksin" on the first day of therapy, adults should take 1 g, the drug is given to children at the rate of 25 mg per 1 kg of weight. Over the next days, these doses are reduced by 2 times. The medicine is drunk 1 time per day. In severe forms of the disease, Erythromycin, Penicillin and some others are prescribed simultaneously with Sulfadimethoxin. The remedy is effective with a duration of treatment of 7 to 10 days. After the body temperature returns to normal, maintenance doses of the drug are taken for another three days.
With infectious eczema, furunculosis, inflammation of the sebaceous glands, take 0.5-1.0 g per day. The course of treatment is from 7 to 30 days. For the treatment of trachoma on the first day, take 1-2 g of "Sulfadimethoxin" orally, and then drink 0.5 g once a day for 10 days. At the same time, a 10% solution of the drug is instilled into the sore eye, 2-3 drops 3-4 times a day.
It should be borne in mind that with the simultaneous use of "Sulfadimetoksin" reduces the therapeutic effect of bactericidal antibiotics. The antimicrobial effect of Sulfadimethoxin is reduced by: para-aminosalicylic acid, barbiturates, Procaine, Benzocaine, Tetracaine. During therapy, regular blood tests are necessary.
Contraindications, side effects of "Sulfadimethoxin"
"Sulfadimetoksin" is contraindicated in case of porphyria, oppression of bone marrow hematopoiesis, chronic heart failure, hepatic and renal failure, azotemia, during pregnancy and lactation, deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity to the components of the drug. The drug can cause unwanted side effects: headache, cholestatic hepatitis, abdominal discomfort, diarrhea, constipation, vomiting, nausea, drug fever, skin rashes, leukopenia, agranulocytosis.
