Bacteriophage staphylococcal mechanism of action. Staphylococcal bacteriophage liquid, sterile liquid for oral, local and external use

Diseases of the ENT organs are distinguished by their wide prevalence among the population and the frequent formation of numerous and sometimes quite serious complications. The generally accepted approach to the treatment of such diseases is considered to be one that is not without its drawbacks due to the development of bacterial resistance to agents with antimicrobial activity.

One of the most successful trends in the treatment of upper respiratory tract diseases of infectious origin is the use of bacteriophages. Information about bacterial viruses first appeared more than a hundred years ago, and the first data on effective treatment with their help were made at the beginning of the 20th century. However, the scope of use of phages is still quite limited. Recently, there has been interest in the possibilities that such therapy opens up. The drug Staphylococcal bacteriophage has become widespread in otorhinolaryngology.

What is this medicine?

Staphylococcal bacteriophage is a bacterial virus that can destroy only strains of staphylococci. It is believed that in one second a bacteriophage is capable of infecting about 10²³ bacterial cells. They work especially well against bacteria that have a dense polysaccharide cell membrane that is difficult for antibiotics to penetrate. In such cases, phage therapy has an advantage over antibiotic treatment.

Bacteriophages and antibiotics are not the same thing. These drugs are not interchangeable, and the decision to switch to phage therapy should only be made by a doctor. Despite the benefits of phages, in some cases it is not possible to achieve a cure without antibiotics. Before use, be sure to consult a doctor.

The use of this medicine is justified only if the cause of the infection is bacteria of the genus Staphylococcus. The most common pathogen is (Staphylococcus aureus). In the annotation for the drug, indications include diseases of various body systems, including enteral, surgical, and urogenital infections.

In ENT practice, it is used for the treatment and prevention of infections of the bronchi, trachea, nose, lungs, ear, throat (otitis, sinusitis, sinusitis, sinusitis, pharyngitis, tracheitis, bronchitis, pneumonia).

Detection of the sensitivity of pathogenic microorganisms to bacteriophage and its use in the early stages of disease development is the most important point in phage therapy.

Sometimes a medicine is prescribed without first determining sensitivity. Most often, in such cases, the doctor uses a combination of staphylococcal bacteriophage with an antibiotic, which enhances the effectiveness of treatment. It is prohibited to use phage monotherapy to treat an infection that occurs with signs of severe intoxication (fever, chills) without consulting a specialist.

How to use staphylococcal bacteriophage?

The drug is available in the form of a transparent solution with a yellowish tint. Before use, you need to pay attention to its color and the absence of sediment in the contents of the bottle.

The medicine is suitable for use both internally (orally) and topically (paranasal sinuses). In the treatment of infectious diseases of the nose and sinuses, the drug is prescribed in a dose of 2 to 10 ml 1-3 times a day. The solution can also be used to irrigate the nasal cavity, gargle and introduce moistened turundas into the nasal passages, which should be left for an hour.

When using, questions often arise about how to gargle correctly or how to drip staphylococcal bacteriophage into the nose, because these nuances are not well covered in the instructions. The solution should not be diluted with other liquids. To prevent the penetration of bacteria, it is better to remove the contents by piercing the stopper with a disposable sterile syringe. Then remove the needle from the syringe and immediately drop it into your nose or gargle, without first pouring the solution into a non-sterile container.

For preventive purposes, in case of unfavorable epidemiological conditions, weakening of the body, it is recommended to instill the bacteriophage into the nose monthly for one or two weeks, 2 times a day.

The effect of treatment with the drug should appear within the first two days. If the condition worsens, you must stop therapy yourself and immediately consult a doctor.

Due to the fact that the solution of staphylococcal bacteriophage contains a live culture of bacterial viruses, a number of rules should be followed when using it:

wash your hands well before use;
treat the bottle cap with a solution containing alcohol;
do not leave the bottle cap on non-sterile objects;
do not keep the bottle open;
Store opened packaging only at a temperature of 2 to 8°C.

The drug staphylococcal bacteriophage is a light yellow liquid, odorless and tasteless. A distinctive feature of all bacteriophages is the ability to selectively destroy a specific type of pathogen, biting into a bacterial cell and feeding on its life-supporting structures, thereby contributing to the rapid death of the cell. Staphylococcal phage acts in this way on staphylococcal bacteria.

The bacteriophage cell includes a head containing single- or double-stranded RNA with deactivated transcriptase in an amino acid shell, and a tail that is approximately 3 times longer than the head.

When attaching to a staphylococcus cell, the phage releases lysozyme, which destroys the cell wall, releasing calcium and activating ATP. The phage injects its RNA into the cell and from this moment the bacteriophage begins to control the genetic apparatus of the cell. Thanks to the synthesis of multiple enzymes, it becomes possible to form many new copies of the phage, capturing new bacterial cells.

Can it be given to children?

The drug is approved for use in children starting from six months of age. When using and selecting the dosage, you must strictly follow the instructions in these instructions.

If a child experiences an adverse reaction to a syringe test, it is not recommended to give the drug. The bacteriophage does not provoke changes in the intestinal microflora, so when consuming it there is no need to resort to antibiotics.

Indications for use

Infectious inflammatory diseases of the ENT organs.
Infections of the genitourinary system.
Intestinal infections and dysbiosis.
Other purulent-inflammatory processes, the diagnosis of which revealed the presence of staphylococci.

Forms of release of the drug and conditions of release from pharmacies

The drug is produced in the form of a solution for oral and external use in opaque glass bottles with a capacity of 20, 50 or 100 ml. Bottles with a capacity of 20 ml are packaged in cardboard boxes of 4 bottles, with a capacity of 50 and 100 ml - produced in individual packaging. All packages have instructions for use inside.

The solution is also available as aerosol, in a 25 ml bottle with instructions for use.

Pills are produced in blisters of 10, 25 and 50 pieces, packed in a cardboard box. One box contains one blister and instructions for use.

Candles Available in packs of 10 pieces in a cardboard box.

Ointment Available in tubes of 10 and 20 grams, in cardboard packaging with instructions for use.

All forms of the drug are available in pharmacies without a prescription.

Instructions for use

The course of treatment with bacteriophage is 6-9 days and involves a combination of rectal and oral administration of the drug.

For rectal use, children under 6 months should be given 10 ml of phage, from 6 months to one year - 20 ml, from one to three years - 30 ml, and older ones - 50 ml.

Dosage for oral use: up to 6 months - 5 ml, from 6 months to a year - 10 ml, from one to three years - 35 ml, from 3 to 8 years - 20 ml, for older ones - 30 ml. Children under one year of age are given half the indicated dosage of the drug in the first two doses, mixed with milk or water.

An aerosol with phage is used to irrigate the oropharyngeal cavity during sore throat, pharyngitis, and to irrigate purulent and inflamed areas of the skin and mucous membranes.

For festering wounds, a combination of topical application (bandage with ointment, change twice a day) and tablets (up to 4 pieces per day) is recommended. Before your appointment be sure to consult your doctor!

Compound

1 ml of solution contains up to 1 ml of active substance – phagolysates of staphylococcal bacteria.

Excipients: preservative 8-hydroxyquinoline sulfate - about 0.1 ml.

Contraindications

In pediatric practice, there are practically no contraindications for the use of bacteriophage preparations. The exception is the occurrence of pathological reactions after a test enema during the use of bacteriophages for infants.

Side effects

When administered subcutaneously into the body, short-term swelling and redness of the surface may be observed.

Otherwise, undesirable effects when taking the drug are possible only in the presence of increased individual sensitivity to the active substance. Before starting to use the product for a child, it is advisable to test for a pathological reaction by administering a microenema with a bacteriophage solution. If adverse reactions occur, oral use of the drug is not allowed.

Analogues

Kubitsin
Trobitsin
Nitroxoline
Dioxidine

Bacteriophages or phages (from ancient Greek φᾰγω - “I devour”) are viruses that selectively infect bacterial cells. Most often, bacteriophages multiply inside bacteria and cause their lysis. As a rule, a bacteriophage consists of a protein shell and genetic material

Bacteriophages are highly effective immunobiological preparations with antibacterial action. Staphylococcal bacteriophage - the drug is intended to combat staphylococcal infections. Instructions for use of the drug Staphylococcal Bacteriophage describe that the bacteriophage is injected into the site of infection.

Staphylococcal bacteriophage is capable of lysing staphylococci, i.e. has the ability to specifically dissolve staphylococcal bacteria isolated during purulent infections.

INSTRUCTIONS for the use of the medicinal product for medical use Staphylococcal bacteriophage

Staphylococcal bacteriophage liquid - instructions for use. Indications for use, composition, pharmacological properties, reviews.

Name of the drug: Staphylococcal bacteriophage.

Dosage form: Solution for oral, local and external use.

Average price for staphylococcal bacteriophage in Russia (2014):

Average price: 880 rub.
Maximum price: 1868 rub.

Compound

Composition of the drug Staphylococcal Bacteriophage: 1 ml of the drug contains the active substance of the sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

Excipients: Preservative 8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate - 0.0001 g/ml (in terms of 8-hydroxyquinoline sulfate, calculated content).

Description: The drug Staphylococcal Bacteriophage is a transparent yellow liquid of varying intensity.

Pharmacotherapeutic group of the drug: MIBP-bacteriophage.

Biological properties: The drug Staphylococcal Bacteriophage causes specific lysis of Staphylococcus bacteria.

Indications

Indications for use of the drug Staphylococcal Bacteriophage:

Treatment and prevention of purulent-inflammatory and enteric diseases caused by bacteria of the genus Staphylococcus in adults and children.
diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
surgical infections (wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hidradenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis);
urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);
enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbacteriosis;
generalized septic diseases;
purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);
other diseases caused by staphylococci.

In case of severe manifestations of staphylococcal infection, the drug is prescribed as part of complex therapy.

For prophylactic purposes, the drug Staphylococcal Bacteriophage is used for the treatment of postoperative and newly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and the early use of the drug Staphylococcal Bacteriophage;

Contraindications to the drug Staphylococcal Bacteriophage:

Individual intolerance or sensitivity to any of the components of the drug.

Use of the drug Staphylococcal Bacteriophage during pregnancy and breastfeeding:

It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Method of administration and dosage of the drug Staphylococcal bacteriophage:

The drug is used for oral administration (oral), rectal administration, applications, irrigation, administration into wound cavities, vagina, uterus, nose, sinuses and drained cavities. Before use, the vial with the bacteriophage must be shaken and inspected. The Staphylococcal Bacteriophage preparation should be transparent and not contain sediment.

Recommended dosages of the drug Staphylococcal Bacteriophage:

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug Staphylococcal Bacteriophage orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the source of infection, Staphylococcal bacteriophage is used:

1. In the form of irrigation, lotions and tamponing in a volume of up to 200 ml, depending on the size of the affected area. In case of an abscess, after removing the purulent contents using a puncture, the drug Staphylococcal Bacteriophage is administered in an amount less than the volume of the removed pus. In case of osteomyelitis, after appropriate surgical treatment, 10-20 ml of bacteriophage is poured into the wound.

2. When administered into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which the staphylococcal bacteriophage is administered for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the staphylococcal bacteriophage is injected through the cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.

4. For purulent-inflammatory gynecological diseases, the drug Staphylococcal Bacteriophage is administered into the cavity of the vagina and uterus in a dose of 5-10 ml once daily, for colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are placed for 2 hours.

5. For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. Staphylococcal bacteriophage is used for rinsing, washing, instilling, and introducing moistened turundas (leaving them for 1 hour).

6. For enteral infections and intestinal dysbiosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine double oral administration with a single rectal administration of a single age-specific dose of the bacteriophage in the form of an enema after bowel movement.

Use of Staphylococcal bacteriophage in children (up to 6 months)

For sepsis, enterocolitis of newborns, including premature babies

The bacteriophage is used in the form of high enemas (through a gas outlet tube or catheter) 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug by mouth. In this case, it is mixed with breast milk. A combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug is possible. The course of treatment is 5-15 days. In case of recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of nosocomial infection in newborns, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, and infected wounds, the drug Staphylococcal Bacteriophage is used in the form of applications twice daily (a gauze cloth is moistened with the bacteriophage and applied to the umbilical wound or to the affected area of the skin).

Side effects of the drug Staphylococcal bacteriophage

None.

Overdose

Not marked.

Interaction with other drugs.

The use of the drug Staphylococcal Bacteriophage is possible in combination with other drugs, including antibiotics.

Special instructions.

Staphylococcal bacteriophage is not suitable for use in bottles with damaged integrity or labeling, if the expiration date has expired, or if they are cloudy.

Due to the presence of a nutrient medium in the preparation Bacteriophage staphylococcus, in which bacteria from the environment can develop, causing clouding of the preparation, it is necessary to observe the following rules when opening the bottle:

wash your hands thoroughly;
treat the cap with an alcohol-containing solution; remove the cap without opening the cap;
do not place the cork with the inner surface on a table or other objects;
do not leave the bottle open
Store opened bottle only in the refrigerator

Opening the bottle of Staphylococcal Bacteriophage and extracting the required volume of the drug can be done with a sterile syringe by piercing the stopper. The drug Staphylococcal Bacteriophage from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the shelf life.

Impact on the ability to drive vehicles and machinery

Not installed.

Release form of the drug Bacteriophage staphylococcal

Solution for oral, local and external use in bottles of 20 ml or 100 ml. 4 or 8 bottles of 20 ml or 1 bottle of 100 ml in a cardboard pack with instructions for use.

Storage and transportation conditions

Storage in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C in a dry place, protected from light and out of reach of children.

Transportation in accordance with SP 3.3.2.1248-03 at temperatures from 2 to 8°C; transportation at temperatures from 9 to 25°C is allowed for no more than 1 month.

Shelf life of the drug Bacteriophage staphylococcal.

Shelf life: 2 years. The drug Staphylococcal Bacteriophage with an expired shelf life cannot be used.

Vacation conditions.

Staphylococcal bacteriophage is sold without a prescription.

Save on social networks:

1 ml of the drug contains the active substance - a sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

pharmachologic effect

Staphylococcal bacteriophage is an immunobiological preparation, phage.

Staphylococcal bacteriophage has the ability to specifically lyse staphylococcal bacteria isolated during purulent infections, incl. Staphylococcus aureus.

Indications for use Staphylococcal bacteriophage

Staphylococcal bacteriophage is used for the treatment and prevention of purulent infections of the skin, mucous membranes, visceral organs caused by staphylococcal bacteria, as well as for dysbiosis:

diseases of the ear, throat, nose, respiratory tract and lungs (sinusitis, otitis, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
surgical infections (purulent wounds, infected burns, abscess, phlegmon, furuncle, carbuncle, hidradenitis, panaritium, infiltrated and abscessed staphylococcal sycosis, paraproctitis, mastitis, bursitis, tendovaginitis, osteomyelitis);
urogenital pathology (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis);
enteral pathology (gastroenterocolitis, cholecystitis, intestinal dysbiosis);
generalized septic diseases;
purulent-inflammatory diseases of newborns (omphalitis, gastroenterocolitis, sepsis);
other diseases of staphylococcal etiology;
prevention of purulent processes in newly infected wounds (abdominal and thoracic surgeries, street and industrial injuries, etc.); for the prevention of nosocomial infections for epidemic indications.

Contraindications for use Staphylococcal bacteriophage

Individual intolerance.

Staphylococcal bacteriophage Side effects

Reactions to the introduction of staphylococcal bacteriophage have not been established.
With intradermal administration, there may be rapidly reversible redness and inflammation.

Drug interactions

The use of staphylococcal bacteriophage does not exclude the use of other drugs.

It is possible to carry out combined treatment with staphylococcal bacteriophage in combination with antibiotics.

Dosage Staphylococcal bacteriophage

An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen (determination of the sensitivity to staphylococcal bacteriophage of strains isolated from the patient).
The staphylococcal bacteriophage is introduced into the source of infection. The duration of the course of treatment is 5-15 days. Doses and route of administration depend on the nature of the source of infection (locally in the form of irrigation, lotions and tamponing; intradermally; in the cavity - abdominal, pleural, articular; into the bladder through a catheter; per os and per rectum). In case of recurrent course of the disease, repeated courses of treatment are possible.

Locally in the form of irrigation, lotions and tamponing with liquid phage in an amount of up to 200 ml, taking into account the size of the affected area, or lubrication with ointment.
It is advisable to treat purulent-inflammatory diseases with localized lesions simultaneously both locally and through the mouth for 7-20 days.
For purulent-inflammatory diseases of the ear, throat, nose, staphylococcal bacteriophage is administered in a dose of 2-10 ml 1-3 times a day; used for rinsing, washing, instillation, introduction of moistened turundas (leaving them for 1 hour).
For boils and carbuncles, liquid staphylococcal bacteriophage is injected directly into the lesion or under the base of the infiltrate, as well as around it. Injections are made daily, every other day, depending on the reaction, in successively increasing doses: for 1 injection - 0.5 ml, then 1 - 1.5 - 2 ml. A total of 3-5 injections are performed per treatment cycle.

For abscesses, staphylococcal bacteriophage is injected into the cavity of the lesion after puncture removal of pus. The amount of the administered drug should be slightly less than the volume of removed pus. When opening an abscess, a tampon richly moistened with staphylococcal bacteriophage is inserted into the cavity.

For chronic osteomyelitis, staphylococcal bacteriophage is infused into the wound immediately after surgical treatment.
To treat deep forms of pyodermatitis, staphylococcal bacteriophage is used intradermally in small doses of 0.1-0.5 ml in one place or, if necessary, up to 2 ml in several places. A total of 10 injections every 24 hours.
Introduction into cavities - abdominal, pleural, articular and others - up to 100 ml of bacteriophage. Capillary drainage is left, through which the bacteriophage is reintroduced every other day, a total of 3-4 times.

For cystitis, a staphylococcal bacteriophage is injected into the bladder cavity using a catheter.
For purulent pleurisy, bursitis or arthritis, staphylococcal bacteriophage is injected into the cavity after removing pus from it in an amount of up to 20 ml. and more, every other day, 3-4 times.
Orally in the form of tablets, staphylococcal bacteriophage is used to treat urogenital infectious pathologies - cystitis, pyelitis, pyelonephritis, endometritis, salpingoophoritis, enteral infections and other diseases caused by staphylococcal bacteria.

For intestinal forms of the disease caused by staphylococcus and intestinal dysbiosis, liquid staphylococcal bacteriophage is used: orally 3 times a day on an empty stomach 1.5-2 hours before meals; rectally - once a day (liquid in the form of enemas or suppositories). For intestinal dysbiosis, treatment is carried out for 7-10 days under bacteriological control. For children in the first days of life, in the first two doses, the staphylococcal bacteriophage is diluted with boiled water 2 times. In the absence of adverse reactions (regurgitation, skin rash), the undiluted drug is subsequently used. In this case, it can be mixed with breast milk.
For sepsis and enterocolitis in newborns, including premature babies, staphylococcal bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day. A combination of rectal (in enemas) and oral (by mouth) use of the drug is possible.

In the treatment of omphalitis, pyoderma, and infected wounds in newborns, staphylococcal bacteriophage is used in the form of applications twice daily (a gauze cloth is moistened with staphylococcal bacteriophage and applied to the umbilical wound or the affected area of the skin).
Recommended dosage of Staphylococcal Bacteriophage:

Age Dose for 1 dose Orally liquid In enema (ml.) Up to 6 months 5-10 ml 20 From 6 to 12 months 10-15 ml 20 From 1 year to 3 years 15-20 ml 40 From 3 to 8 years 20-50 ml 40-100 From 8 years and older 20-50 ml 40-100 The frequency of taking the liquid drug is 2-3 times a day.

Staphylococcal bacteriophage is used for prophylaxis in an amount of 50 ml. for irrigation of postoperative wounds, etc.
In order to prevent sepsis and enterocolitis in newborns with intrauterine infection or the risk of nosocomial infection, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

Precautionary measures

Liquid staphylococcal bacteriophage is not suitable for use if it is cloudy or has flakes.

Latin name:
Bacteriophagum Staphylococcum
ATX code: J01XX
Active substance:
Manufacturer: Biomed, Russia, etc.
Conditions for dispensing from a pharmacy: On prescription
Price: from 250 to 850 rub.

Staphylococcal bacteriophage is an effective antibacterial drug against staphylococcal infections for systemic use.

Indications for use

Staphylococcal bacteriophage is used for ENT patients with: sinusitis, sinusitis, otitis, tonsillitis, pharyngitis, laryngitis
In pulmonology: pleurisy, tracheitis, bronchitis, pneumonia
Surgery: treatment of postoperative wounds to prevent infection and to detect primary infection; use in purulent surgery: carbuncles, boils, phlegmon, complicated mastitis, paraproctitis, gastroenterocolitis, cholecystitis
Combustiology: burns and complicated conditions
Traumatology: purulent bursitis, osteomyelitis of various etiologies
Pediatrics: newborns with omphalitis, conjunctivitis, gastroenterocolitis, sepsis, pyoderma
Urology and gynecology: urethritis, cystitis, salpingitis, pyelonephritis, endometritis, dysbacteriosis.

Compound

The main active substance is a sterile filtrate of Staphylococcus bacteria, the stabilizer is quinosol.

Medicinal properties

Staphylococcal bacteriophage is a drug that has a specific effect on the most common strains of staphylococci. When combined with a bacterium, it dissolves it and removes the remaining decay from the body.

It is an antibacterial drug with immunobiological effects and is prescribed for the treatment of infectious diseases caused by staphylococci. A wide spectrum of action on pathogenic strains gives effective results in complex treatment. Does not affect beneficial bacteria found in the human body.

Average price from 250 to 850 rubles.

Release forms

At the moment, only one form of release is registered in Russia - a solution. You can find it in the following volumes:

Bottles of sterile solution 100 and 50 ml, transparent yellowish liquid without sediment for internal and external use - packaged one in a cardboard box
Transparent sterile yellowish solutions in 20 ml bottles - pack of four in one cardboard box.

Mode of application

Before use, you must check the expiration date and condition of the drug. If there is visible damage to the packaging or a change in the state of the liquid (sediment, cloudiness), the medicine should not be used. Normally, any solution should remain transparent without sediment.

Oral solutions also three times a day 30-60 minutes before meals. Children up to 6 months: 3-5 ml, up to one year: 8-10 ml, up to three years: 12-15 ml, up to eight years: 18-20 ml, from eight years: 25-30 ml. The dose of the medicine and the duration of therapeutic treatment are prescribed exclusively by the doctor.

Before using the drug, a tolerance test for this drug must be carried out.

Depending on the location of the infection, the following types of manipulations are performed: irrigation, tamponade, washing of drainage cavities, drip injection into joint cavities and pleural spaces, various types of applications of no more than 200 ml per procedure.

Courses of treatment range from 5 to 15 days, depending on the pathology, then a control sample is taken. If necessary, treatment is extended.

Cross-drug interactions

Can be used with other antibacterial and immunobiological drugs, as well as in combination with other groups of drugs.

Side effects

Not identified. In rare cases, individual intolerance.

Contraindications

No contraindications have been identified.

Can be used by: pregnant, nursing mothers, children from birth under the supervision of an appropriate specialist.

Storage conditions

Analogues

Staphylococcal toxoid

NIIEM im. N.F. Gamaleyi, Russia

Price from 510 to 1250 rubles.

It is a clear, colorless liquid (sometimes light yellow) available as a solution for subcutaneous administration. Used to treat staphylococcus in acute or chronic form.

pros

Contains no preservatives
The drug does not have a clear toxic effect on the body

Minuses

Under the slightest storage conditions, the solution can no longer be used
After the injection, local and general reactions of the body may be observed.

In this section, you can familiarize yourself with the different types of bacteriophages that are used for other infections and diseases.

Coliproteus

Microgen, Russia
Price from 650 to 750 rub.

Recommended for use in: enteral infections, urological and gynecological diseases, ENT and surgical pathologies, inflammatory diseases with purulent discharge in newborns, septic diseases caused by Escherichia coli or Proteus. Release form: sterile solution for internal and external use.

pros

Possible during pregnancy
Coliproteus bacteriophage liquid is used for children from birth.

Minuses

Coliproteus bacteriophage in rare cases can cause an allergic reaction
The use of the drug involves complex manipulations to maintain the sterility of the solution.

Salmonella

Microgen, Russia
Price from 640 to 770 rub.

During periods of infectious outbreaks, it is recommended to use it as a prophylactic drug for family use, in the comprehensive fight against nosocomial infection. Prescribed for children from one year of age and adults after consultation with a doctor. Children under one year of age are prescribed Salmonella bacteriophage ABCDE. Release form: in the form of a solution of 100 ml and 20 ml and in the form of tablets for the treatment of bacterial carriage and diseases caused by salmonella.

pros

Effective results from using the solution in children
Can be combined with other antibacterial drugs and anti-inflammatory drugs (staphylococcal bacteriophage)

Minuses

Prescribed only after test results
Not always available for sale.

Klebsiella pneumonia

Microgen, Russia
Price from 490 to 650 rub.

It affects only Klebsiella strains and does not have a negative effect on the body. The bacteriophage Klebsiella pneumonia helps in the complex treatment of otitis, stomatitis, pharyngitis, and tonsillitis. To treat diseases associated with the nasopharynx, you can put drops into the nose or use an aerosol during pregnancy.

pros

Klebsiella pneumonia bacteriophage purified can be used by pregnant women
Purified Klebsiella pneumoniae bacteriophage can be used for children from birth in accordance with the dosage by age

Minuses

Klebsiella pneumoniae bacteriophage is prescribed only after clinical tests and established sensitivity to infection
The dosage of the drug is calculated only by the doctor.

Dysenteric

Microgen, Russia
Price from 200 to 610 rub.

Antibacterial drug for the therapeutic treatment of dysentery and prophylactic use. Available in liquid and tablet form.

pros

Good tolerability of the drug
Bacteriophage dysentery polyvalent can be prescribed with other drugs in complex therapy

Minuses

Contraindicated during pregnancy
To control the correct choice of treatment process, a sensitivity analysis should be performed.

Proteaceae

Microgen, Russia
Price from 200 to 610 rub.

Microgen, Russia
Price from 60 to 250 rub.

Used by adults and children over eight years of age for nasal irrigation. Bacteriophage proteus liquid and bacteriophage coliproteus liquid are similar in name, but differ in their effects on the body.

pros

Convenient to use aerosol
Proteus bacteriophage liquid differs from simple Proteus bacteriophage in that it can be used for children from the first days of life

Minuses

All types of use of the drug only as prescribed by a doctor after special diagnostic studies.