Vitamin Aevit - why is it so useful for women? Rules and features of application. How necessary is Aevit during menopause?

Composition and release form of the drug

◊ Capsules soft gelatinous, spherical in shape, from yellow to light brown, filled with an oily liquid from light yellow to dark yellow, without a rancid odor.

* 1 g of retinol substance (vitamin A palmitate, substance stabilized by BHA/BHT - oil solution) contains: - 1.7 million IU, butylated hydroxyanisole (BHA) - 9 mg, butylated hydroxytoluene (BHT) - 9 mg.

PRING] sunflower oil - up to 200 mg.

Shell composition (in terms of absolute dry matter): gelatin - 52.75 mg, glycerol - 16.8 mg, methyl parahydroxybenzoate - 0.45 mg.

10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
20 pcs. - polyethylene cans (1) - cardboard packs.
30 pcs. - polyethylene cans (1) - cardboard packs.
40 pcs. - polyethylene cans (1) - cardboard packs.
10 pieces. - contour cell packaging (50) - cardboard boxes (for hospitals).
10 pieces. - contour cell packaging (100) - cardboard boxes (for hospitals).
10 pieces. - contour cell packaging (200) - cardboard boxes (for hospitals).
20 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
20 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).
30 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
30 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).
40 pcs. - polyethylene cans (42) - cardboard boxes (for hospitals).
40 pcs. - polyethylene cans (54) - cardboard boxes (for hospitals).

pharmachologic effect

A combined drug whose effect is determined by the properties of its constituent fat-soluble A and E.

Retinol (vitamin A): is a necessary component for the normal function of the retina of the eye: by binding to opsin (the red pigment of the retina), it forms visual purple rhodopsin, which is necessary for visual adaptation in the dark. Vitamin A is necessary for bone growth, normal reproductive function, embryonic development, for the regulation of division and differentiation of the epithelium (increases the reproduction of epithelial skin cells, rejuvenates the cell population, inhibits keratinization processes). Vitamin A takes part as a cofactor in various biochemical processes.

Function of α-tocopherol (vitamin E): as an antioxidant, it inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. Together with selenium, it inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transfer system) and prevents hemolysis of red blood cells. It is a cofactor of some enzyme systems. Restores capillary blood circulation, normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

Pharmacokinetics

Tocopherol: When taken orally, approximately 50% of the dose taken is slowly absorbed, C max after 4 hours. Absorption requires the presence of bile acids. Deposited in the adrenal glands, pituitary gland, testes, adipose and muscle tissue, red blood cells, and liver. It is metabolized and excreted from the body (unchanged and in the form of metabolites) with bile (over 90%) and urine (about 6%).

Retinol: When taken orally, retinol is absorbed almost completely; even with excessive administration, no more than 10% of the administered amount is excreted in the feces. During metabolism, retinyl palmitate, retinol, retinal and retinoic acid are formed. It is distributed unevenly in the body: the largest amount is in the liver and retina, the smaller amount is in the kidneys, heart, fat depots, lungs, lactating mammary gland, adrenal glands and other endocrine glands. Retinol, retinal, retinoic acid are secreted by hepatocytes in the bile, retinoyl glucuronide is excreted in the urine.

Elimination of fat-soluble vitamins (tocopherol and retinol) occurs slowly, so repeated doses lead to accumulation.

Indications

Hypo- and avitaminosis A and E, as well as conditions of increased body need for vitamins A and E and/or decreased intake of them into the body: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, cirrhosis of the liver, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and colds), hemeralopia, xerophthalmia, keratomalacia, poor and unbalanced nutrition (including parenteral nutrition), rapid weight loss , nicotine addiction, drug addiction, a state of prolonged stress, taking cholestyramine, colestipol, mineral oils, iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids, hyperthyroidism.
Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia.

Contraindications

Hypersensitivity, hypervitaminosis A and E, children (up to 18 years), pregnancy, lactation.

Carefully

Thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (CHF, chronic glomerulonephritis, etc.), liver cirrhosis, viral hepatitis, renal failure, alcoholism, old age, hypoprothrombinemia (due to vitamin K deficiency - may increase with a dose of vitamin E more than 400 ME).

Dosage

Inside. The dosage regimen is individual, depending on the indications, the patient’s age and the clinical situation.

Side effects

Systemic reactions: allergic reactions.

From the digestive system: pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea); with long-term use in large doses, exacerbation of cholelithiasis and chronic pancreatitis is possible.

Local reactions(with intramuscular injection) - pain, infiltration, soft tissue calcification.

Drug interactions

Retinol weakens the effect calcium preparations, increases the risk of developing hypercalcemia.

Cholestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (their dose may need to be increased).

Oral contraceptives increase the concentration of retinol in.

Isotretinoin increases the risk of developing retinol toxicity.

Simultaneous use tetracycline and retinol in high doses (50 thousand units and above) increase the risk of developing intracranial hypertension.

Tocopherol (vitamin E) enhances the effect GCS, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides. Taking vitamin E in high doses may cause vitamin A deficiency in the body.

Tocopherol (vitamin E) increases efficiency antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).

Simultaneous use of vitamin E at a dose of more than 400 IU/day

Often, due to lack of sleep, heavy physical activity and strict diets, the human body weakens. Nails peel, hair falls out, and complexion becomes dull. To support it, it is recommended to take vitamin complexes. Among the latter, Aevit especially stands out. But before you start taking the drug, you need to take a closer look at the instructions for use. So, why take it?

What is Aevit

Aevit is a complex containing two main components: vitamins A and E. The drug is available in the form of yellow capsules and ampoules for intramuscular injection. The latter are available only by prescription and are not used to improve the condition of skin, hair and nails. Capsules are stored at a temperature not exceeding 20 o C for two years from the date of manufacture.

One Aevita capsule contains:

• 10,000 IU vitamin A (retinol);
• 100 mg vitamin E (tocopherol).

Aevit is a yellow capsule that contains tocopherol and retinol.

To understand the benefits of the drug, it is necessary to consider each component separately:

1. Vitamin A: helps strengthen the immune system and improve metabolic processes in tissues, prevents the occurrence of pathologies of the respiratory and digestive systems, promotes the rejuvenation of cells and tissues, increases visual acuity, takes part in the formation of bones and has a positive effect on the functions of the glands.
2. Vitamin E: fights free radicals in the body's cells, helps normalize metabolic processes, improves blood circulation, prevents a number of cardiovascular diseases, supports reproductive function, prevents cancer and promotes the activation of the immune system in general.

Interestingly, retinol enhances the antioxidant properties of vitamin E. That is why the components of the drug are especially effective together.

Why and how to take it for women

Women take Aevit for several purposes:

• strengthen hair;
• improve skin condition;
• make nails stronger;
• normalize hormonal levels;
• improve the condition of the reproductive system.

For facial skin

Due to a lack of vitamins A and E, the skin takes on a dull color, small rashes and peeling appear. In this case, there is a high probability of premature wrinkles forming. If such problems arise, usually take one capsule of Aevita daily for 2 weeks.

To improve skin health, Aevit can be added to creams or taken orally

In addition, the product can be used externally. To do this, simply crush one Aevita capsule and add the resulting oil to your favorite face cream. You will receive a product enriched with vitamins. After just a few weeks of use, you can notice how your skin has changed for the better: pimples have dried out, redness has gone away and fine wrinkles have smoothed out. This method can be used on an ongoing basis.

Aevit perfectly fights dry skin on the lips. Crush the capsule and apply its contents to the problem area. After the product is absorbed, apply your regular lip balm. You can do the procedure daily.

For the skin around the eyes

The first signs of aging usually appear on the skin around the eyes. A mask with Aevit will help refresh problem areas. The procedure is performed in several stages:

1. Cleanse your skin of cosmetics and accumulated impurities. An ordinary washing gel or micellar water is ideal for this.
2. Pierce the Aevit capsule with a clean needle.
3. Rub vitamin oil into the skin around the eyes using the pads of your fingers. Try to do this along the lines of the massage: start from the inner corner and follow to the outer, completely covering the upper and lower eyelids.

   Try to massage the skin around your eyes as gently as possible

4. For the first procedure, five minutes will be enough. After this time, remove any remaining emulsion using a dry cotton pad. Further, the duration of exposure of the mask can be increased. The maximum is twenty minutes.
5. At the end of the procedure, lubricate the skin with a cream intended for the area around the eyes.
6. It is advisable to do the mask in the evening. As for the frequency, look at the condition of the skin. If it is excessively dry, then the procedure should be performed as often as possible. If you are making a mask for prevention, then twice a week will be enough.
7. You can supplement the composition with banana and mashed potatoes, cream and oatmeal. Take two teaspoons per three capsules of Aevit.

   Banana puree will additionally moisturize the skin of the eyelids

Video: skin care around the eyes with Aevit

For hair

To strengthen hair, Aevit in the form of ampoules is more suitable, since it will be easier to use the drug. Take burdock and flax oil as a base. Combine the components in a 1:1 ratio and add 2 ampoules of Aevita to the resulting mixture. Mix the emulsion thoroughly. Apply the product to the root zone and wait until the composition is evenly distributed throughout the hair. To speed up this process, give a light head massage.

You can also use castor oil as a base, which significantly accelerates hair growth.

Flaxseed oil is good for hair care

After treating your hair with the mixture, wrap your head with cling film. After an hour, rinse off the product under strong water pressure. There is no need to use shampoo, since the mask remaining on the hair will remain in effect for several more hours.

It will also be beneficial for hair to take Aevit internally. One capsule per day will be enough. Course - 4 weeks. Then you need to take a break for a month and, if necessary, resume treatment.

For nails

The most effective way to use Aevit for nails is an emulsion of olive oil and the drug itself. The ingredients are taken in a 1:1 ratio. Rub the resulting product into the cuticle until completely absorbed.

Olive oil in combination with Aevit perfectly strengthens nails and nourishes the cuticle

To strengthen your nails, it is useful to add a few drops of Aevit to your regular hand cream. In addition, taking capsules orally also helps improve the health of the plates and cuticles.

For other purposes

To normalize hormonal levels and improve the condition of the reproductive system, Aevit is taken in accordance with the doctor’s recommendations. Some are prescribed two capsules a day, others one. Be sure to consult with a gynecological specialist; do not engage in amateur activities when treating such serious disorders.

Why and how to take it for men

In addition to general strengthening of the body, Aevit affects men as follows:

1. The effect of Aevit is similar to the action of hormones that are responsible for muscle growth. Athletes often use this. To achieve maximum effect, it is enough to take one or two capsules of the drug per day.
2. Doctors prescribe Aevit for men with reproductive disorders. Thanks to the drug, sperm become more active, making conception more likely.
3. Aevit is recommended for increased physical activity. Taking the drug accelerates muscle recovery.

A regularly exercising man needs to take additional vitamins.

Before you start taking Aevit to build muscle or improve reproductive function, you should consult with your doctor. But if you want to use the drug to strengthen the immune system, then take one capsule a day for a month. Then you need to take a break for several weeks and repeat the treatment.

Interestingly, Aevit is suitable for men, as well as women, to improve the condition of their skin, hair and nails. The methods of application are the same as for the fair half of humanity.

Why and how to take it for children

Aevit is indicated for children in the following cases:

1. Avitaminosis. This is a lack of certain substances in the body, due to which the general condition of the child worsens significantly.
2. Developmental delay. The child’s body is constantly growing, so it needs nutrients, vitamins and minerals. If there is a deficiency of several elements at once, then development is slowed down. To prevent this from happening, children need to regularly take vitamins, including Aevit.
3. Loss of visual acuity. Schoolchildren and students read a lot and work on the computer. In this regard, people at an early age often lose their vision completely or partially. Aevit is a good prevention of such problems.
4. Great physical activity. In order for muscles to recover quickly, it is necessary to constantly maintain a balance of vitamins and minerals in the body. Aevit is one of the most important elements.
5. Dry hair, brittle nails and dull skin. Often these problems arise in children who are busy with studies and various classes. Aevit will help support a young body.

It is very important for children to receive the necessary vitamins and microelements, but Aevit is not recommended for children under 14 years of age.

For children, Aevit is prescribed by a doctor. It is not recommended to take the drug under 14 years of age. Once you reach this age, consult your doctor for advice on dosage and side effects. If the specialist deems it necessary, he will prescribe Aevita for the child.

Contraindications, side effects and overdose

Despite its beneficial properties, the drug has the following contraindications:

1. Allergy to vitamins A and E.
2. Thyrotoxicosis.
3. Glomerulonephritis.
4. Inflammatory processes in the kidneys (with extreme caution).
5. Atherosclerosis.
6. Pregnancy and lactation (only with the permission of the supervising specialist).
7. Age up to 14 years.
8. Cirrhosis, viral hepatitis, cholecystitis (prescribed only by a doctor).

In addition, the following side effects may occur when taking Aevit:

• diarrhea;
• nausea;
• vomit;
• rash;
• redness;
• lethargy;
• drowsiness;
• headaches;
• dizziness;
• convulsions.

To avoid unpleasant consequences, be sure to consult your doctor before starting to take the drug and strictly follow the prescribed dosage.

A and E are fat-soluble vitamins. Such substances can accumulate in the body, so there is no point in taking them constantly. Otherwise, you are inviting an overdose, which in turn can lead to side effects.

Main manufacturers of Aevit

The most famous manufacturers of Aevit are:

• Decamevit;
• Makrovit;
• Hexavit;
• BoriVit;
• Vitaminel;
• Aevit Mite;
• Meligen;
• Bitra.

Aevit is produced by many companies, but the composition is almost always the same

The composition of the drugs is practically the same, so rely on the doctor’s opinion and the price. Try not to buy slickly cheap Aevit, as it may not be of high quality.

Foods rich in vitamins A and E

Vitamin A is found in foods of both animal and plant origin. It must be taken into account that vegetables, fruits and greens do not contain fat, due to which the substance is better absorbed. Therefore, do not forget to add cream to carrot juice and vegetable oil to salad.

The highest concentrations of vitamin A are found in the following foods:

• chicken liver;
• beef liver;
• acne;
• butter;
• chicken eggs;
• hard cheese;
• carrot;
• sorrel;
• parsley;
• dried rose hips;
• paprika;
• tomatoes;
• pumpkin;
• apricots;
• persimmon;
• viburnum.

It is almost impossible to overdose on retinol from food. In addition, vitamins are better absorbed from food, so if possible, consume these foods as often as possible.

Photo gallery: what foods contain vitamin A

Fish oil can be purchased in capsules or liquid form
Chicken liver is very tender and tasty, especially in vegetable stew Beef liver is tough, but if you cook it in a frying pan it will be incredibly tasty Butter is useful to add to porridge in the morning Eggs are an excellent breakfast Cheeses can be added to dishes or eaten separately Sorrel contains a lot of fiber and vitamin A Parsley harmonizes well with any vegetables Dry rose hips can be added to any hot drinks
Paprika will go well in any hot dish Baked pumpkin with honey is an excellent dessert Apricots can be eaten in front of the TV instead of chips and croutons Persimmons are very sweet and juicy, it’s better to eat them fresh Viburnum has a peculiar taste, but is very healthy Tomatoes are best eaten fresh or stewed

Aevit is a multivitamin complex based on a large amount of vitamins A and E. They are necessary to enrich the body, restore its performance and vitality. There are a number of features on how to take Aevit vitamins for women.

Aevit vitamins in capsules help the body restore its normal metabolism and help supply cells with oxygen. This has a positive effect on the condition of the skin, nails and hair - they become strong and begin to grow faster.

Doctors usually prescribe this drug to their patients in cases where they are diagnosed with a lack of vitamins A and E. This occurs due to prolonged malnutrition, digestive system disorders, and impaired absorption of any minerals. Also, a deficiency of vitamins A and E negatively affects the menstrual cycle and muscular dystrophy. You need to take Aevit vitamins when:

Remember, your doctor should prescribe vitamins; only he can determine the most suitable dosage for your body. If you take too large a dose of Aevit, there is a high risk of developing digestive disorders, headaches and dizziness.

Features of the use of Aevit in women

Doctors have long understood why women take Aevit. The answer here is obvious: strengthen your hair and nails, make your skin softer. Also, this complex of vitamins has a beneficial effect on the state of the reproductive system and normalizes hormonal levels in mastopathy. Women can take this complex if:

Despite concerns, Aevit vitamins cannot provoke an overdose. However, try not to exceed the average daily dose of the drug.

You will be able to feel the first results from this therapy within a few weeks: the skin becomes healthy and soft, the nails become stronger and begin to grow faster. If you don’t know why you should take Aevit, your local physician should tell you about it.

Aevit for skin beauty

Aevit is extremely useful for the condition of the skin. It is the skin that can show how the body actually functions: if it is healthy, then everything is fine inside; if acne is constantly present on it, it has an unattractive color - which means you need to change your diet and lifestyle. Due to a long-term deficiency of vitamins A and E, the face becomes pale, the skin on it begins to dry out and peel off. Also, such skin is most susceptible to the formation of acne and wrinkles. To restore attractiveness to your face, it is recommended to take 1 capsule of Aevita every day for two weeks. However, your doctor may prescribe a different treatment regimen for you.

To improve the condition of the skin, the complex can be used externally. To do this, you need to prepare a very simple remedy at home. All you need is to add a few drops of vitamin liquid to your favorite face cream. After this, use the medications as usual.

In just a month, you will be able to evaluate how your skin has changed: acne and redness have disappeared, wrinkles have become less pronounced. Vitamin Aevit also works great against dry lips and cracks on them. Squeeze out the contents of one capsule, thoroughly treat the affected area and wait until completely absorbed.

Application of Aevita for hair beauty

Aevit vitamins are often used for the beauty and strength of your hair. However, if you decide to use them for this purpose, choose ampoules - this will make them easier to use. Preparing a vitamin complex is quite simple; for this you will need burdock and linseed oil. Mix them in equal proportions, then add 2 ampoules of Aevita. The resulting mask must be thoroughly mixed and then applied to the hair roots. It is best to do this with massaging movements so that the product is evenly distributed throughout the head and has time to be absorbed.

As a base oil, you can use castor oil, which perfectly strengthens hair and accelerates its growth.

After you have treated your entire head, wrap it in film and wrap a towel over it. This will speed up the absorption process and prevent you from ruining your clothes and furniture. On average, such a vitamin mask needs to be left on for an hour, after which it must be washed off with plenty of water. Immediately after use, you will notice that your hair has become soft and silky.

How to use Aevit

The benefits of Aevit vitamins will appear if you take them correctly. Capsules should be taken strictly after meals, washed down with clean water.

Instructions for use:

Pharmacological actions of Aevit

Aevit is a vitamin complex preparation with immunostimulating and antioxidant properties. The Aevit complex, reviews of which are definitely positive from doctors and patients, consists of two vitamins - A (retinol palmiate) and E (alpha-tocopherol acetate). Aevit vitamins promote tissue regeneration, participate in lipid and protein metabolism, have a positive effect on vision, support the reproductive function of the body, improve blood circulation, restore vascular permeability and tissue trophism.

All the effects described above from the use of Aevit are possible due to the pharmacological properties of vitamins A and E.

Vitamin A is responsible for tissue metabolism, can increase cellular and humoral immunity, enhances myelopoiesis, and improves the function of macrophages. By taking vitamin A, you can reduce the risk of diseases of the mucous membranes of the respiratory tract and digestive tract. Thanks to the participation of this vitamin in the Aevit complex, its use slows down keratinization and rejuvenates cells. The beneficial effect of the drug Aevit on reproductive function is also due to the participation of vitamin A in this complex. In addition, retinol palmiate is involved in the formation of the visual signal, bone tissue, promotes bone growth, and has a positive effect on the functioning of the sweat, sebaceous, and lacrimal glands.

Also, vitamin A, thanks to the unsaturated bonds of the retinol molecule, interacts with different types of radicals and stimulates the antioxidant function of vitamin E, which, in turn, being the second important component of Aevit, prevents the oxidation of retinol, thereby preventing the formation of toxic products.

In addition, vitamin alpha-tocopherol acetate (E) is responsible for regulating metabolic processes in the human body, protecting cells from the action of free radicals, preventing hemolysis of red blood cells, and has a positive effect on microcirculation and tissue trophism, and the vascular system.

Alpha tocopherol also stimulates immunity, both general and humoral, and cellular. Thanks to this component of the Aevit complex, the activity of T-lymphocytes increases. In addition, in combination with vitamin A, normal formation of the reproductive system and embryonic development is ensured.

The pharmacokinetic properties of Aevit are determined by the pharmacokinetics of its components.

Absorption of Aevit: Vitamin E is absorbed in the digestive tract, and vitamin retinol is absorbed in the gastrointestinal tract. The components of Aevita, vitamins A, E, are distributed evenly in tissues and organs, while excess vitamin A is deposited in the liver, and vitamin E is deposited in muscle, adipose tissue, adrenal glands, testes, liver, and red blood cells.

Metabolism of Aevit: Vitamin A is metabolized in the liver into active and inactive metabolites. Vitamin E forms only pharmacologically inactive metabolites during metabolism.

Removal of Aevit: retinol acetate is excreted as metabolites in urine and bile. This happens slowly: after a one-time use, a third of the vitamin taken is removed from the human body for another three weeks. Vitamin E is excreted only in bile, and in urine only in small quantities.

Indications for use of Aevita

Due to its complex composition, Aevit is prescribed for a number of diseases. Therapy using Aevit is prescribed to patients who, for various reasons, require long-term intake of large amounts of vitamins E and A.

According to Aevit’s instructions, this is necessary and justifies itself in a number of cases:

Impaired microcirculation and tissue trophism;

Vascular atherosclerosis;

Endarteritis obliterans;

Psoriasis, lupus erythematosus;

Optic nerve atrophy, night blindness (hemeralopia), keratomalacia, xerophthalmia, retinitis pigmentosa;

The use of Aevit is also indicated for those patients who have limited nutrition and a reduced intake of vitamins A and E in a natural way, for the following diseases and conditions:

• diarrhea;
• gastrectomy;
• steatorrhea;
• Crohn's disease, malabsorption, celiac disease;
• cholestasis in the chronic stage, obstructive jaundice, obstructed bile ducts, cirrhosis of the liver;
• pancreatic disease - cystic fibrosis;
• infectious diseases in acute and chronic conditions;
• poor nutrition, rapid weight loss (Aevit vitamins are often prescribed to those on parenteral nutrition to compensate for the lack of retinol and alpha-tocopherol acetate)
• alcohol, nicotine, drug addiction;
• prolonged stress;
• use of medications, mineral oils that contain iron (for example, neomycin, cholestyramine, colestipol)
• a diet that causes an increased intake of polyunsaturated fatty acids;
• hyperthyroidism
• peripheral neuropathy;
• abetalipoproteinemia;
• necrotizing myopathy.

How to use Aevit

Aevit vitamins are taken after meals, swallowed whole (not chewed) and washed down with water.

The average course of treatment, according to Aevita’s instructions: for an adult – 30 – 40 days. one capsule once every 24 hours. But more individual dosages of Aevita and the duration of the course are prescribed by the doctor who is seeing the patient. According to observations and reviews, Aevit, if used incorrectly, can lead to undesirable consequences.

For a more precise prescription and the possibility of repeating the use of Aevit (only 3 months or six months after the end of the last course - according to the instructions of Aevit), it is necessary to know exactly the nature of the disease and the characteristics of the patient’s body.

Description of side effects of Aevit

According to the description and reviews, Aevit is well tolerated, but there are statistics of side effects associated with the use of Aevit:

1) vomiting, nausea, allergic manifestations, gastralgia, stool disorders - isolated cases associated only with the individual characteristics of the patient’s body;

2) exacerbation of chronic pancreatitis, cholelithiasis - in those who took Aevit for a long time;

3) hypervitaminosis A. It is expressed in damage to the peripheral and central nervous system - sleep disturbances, irritability, headache, paresthesia, apathy. Damage to the skin may also appear - cracks and dryness of the feet and palms, seborrhea, alopecia. According to reviews, Aevit also led to pain in the joints, enlargement of the spleen, liver, and changes in gait, but all this was observed during long-term use of the drug and in dosages that exceeded the recommended ones.

Contraindications to the use of Aevit

1. Individual intolerance to the vitamins included in Aevita;

2. Thyrotoxicosis, chronic glomerulonephritis, and chronic circulatory failure;

3. Myocardial infarction, risk of thromboembolism, severe atherosclerosis of the coronary arteries, acute and chronic inflammation of the kidneys (Aevit is prescribed, but with great caution);

According to the instructions, taking Aevita during pregnancy and lactation is allowed only with the permission of a doctor.

*MINSKINTERCAPS* Shanghai Donghai Pharmaceutical Co., Ltd. Donghai ICN October OJSC Alina Pharma LLC Altaivitamins CJSC BRYNTSALOV BRYNTSALOV-A, CJSC Kvadrat-S, LLC LUMI LLC MARBIOPHARM OJSC MINSKINTERKAPS Minskinterkaps, UP Mirrolla, LLC Moskhimfarmpreparaty FSUE im. Semashko Nizhpharm JSC Update of PFK RealCaps JSC, Ufavita JSC Ufavitsky Vitamin Plant JSC Pharma AD FARMAGEN FARMAGEN JSC Pharmgroup, LLC Pharmstandard-Oktyabr, JSC FEREIN FP Meligen, JSC

Country of origin

Bulgaria China Republic of Belarus Russia

Product group

Multivitamin preparations

Dietary supplement (BAA) to food

Release forms

• 10 - contour cell packaging (3) - cardboard packs of 10 capsules 10 capsules in a blister in a boom. pack 10 capsules in contour packaging 10 capsules in a pack of 10 pcs. - contour cell packaging (2) - cardboard packs. 20 capsules per pack 30 capsules per pack 30 tabs per pack 40 drops per pack capsules - 20 pcs per pack. capsules 300 mg - 400 pcs per pack. spherical capsules of 250 mg, 10 capsules per blister. spherical capsules 250 mg, 10 capsules per blister, 2 blisters in consumer packaging. pack 10 capsules pack 20 capsules pack 20pcs pack 30 caps

Description of the dosage form

• 10 capsules weighing 300 mg. 20 capsules weighing 300 mg. gelatin capsules yellow gelatin capsules of 0.2 spherical shape. capsules soft gelatin capsules, spherical in shape, transparent, from light yellow to dark yellow. The capsules are soft gelatin, spherical in shape, from dark yellow to light brown, filled with an oily liquid from light yellow to dark yellow, without a rancid odor. capsules 200 mg capsules, 1 capsule contains 4.0 mg Vit E (40% of the recommended daily dose), 015 mg Vit A (18.7% of the recommended daily dose) Soft gelatin capsules, yellow in color, with taste and odor, characteristic of this product weighing 330 mg. Presence of sediment is allowed. Soft gelatin capsules of spherical shape from yellow to light brown, filled with an oily liquid from light yellow to dark yellow, without a rancid odor. Film-coated tablets weighing 450 mg. Daily dose 1 tablet. The degree of satisfaction in vitamin E from the daily requirement is 1000% (100 mg), which does not exceed the upper permissible level of consumption - 150 mg, in vitamin A - 375% (3 mg), which does not exceed the upper permissible level of consumption - 3 mg. Nutritional and energy value of 100 g: fats – 1 g, carbohydrates – 26 g, calorie content 115 kcal (480 kJ).

pharmachologic effect

Retinol palmitate (vitamin A) is involved in the synthesis of proteins and lipids, regulates the balance of minerals, hyaluronic acid - the main intercellular substance. Stimulates cellular metabolism and the process of formation of new cells. Vitamin A modulates the processes of differentiation of epithelial cells, takes part in the development of secretory glands, keratinization processes, regeneration of mucous membranes and skin. It has a beneficial effect on eye function: it is necessary in the synthesis of visual pigments involved in twilight and color vision. The participation of vitamin A in the synthesis of mucopolysaccharides - components of connective tissue, cartilage and bones, contributes to the formation and strengthening of bone and muscle tissue. Vitamin A is necessary in the synthesis of sex hormones and is involved in the formation and maturation of sperm and eggs. In addition, vitamin A maintains the functioning of the immune system in a normal functional state by stimulating the formation of interferon, immunoglobulin A, and lysozyme. Plays an important role in redox processes. Alpha-tocopherol acetate (vitamin E) has a pronounced antioxidant effect, inhibits the development of free radical reactions, and prevents the formation of peroxides that damage cellular and subcellular membranes. Restores capillary blood circulation, normalizes tissue permeability, increases tissue resistance to hypoxia. Under the influence of vitamin E, protein synthesis occurs: collagen in subcutaneous tissue and bones, contractile proteins in skeletal, smooth muscles and myocardium, proteins of the mucous membranes and placenta, liver enzymes, creatine phosphokinase, vasopressinase and gonadotropic hormones. Vitamin E is an effective immunomodulator that helps strengthen the body's immune defenses. Vitamins A and E are fat-soluble vitamins, do they have synergism? the effect of enhancing biological activity, stronger than the sum of the effects when used separately. The presence of flaxseed oil in the product promotes better absorption of vitamins A and E due to the polyunsaturated fatty acids contained in the oil (omega-3, omega-6). Regular intake of vitamins A and E: helps prevent regressive processes of eye tissues and restore normal vision; improves the structural and functional condition of skin and hair; stimulates the activity of the reproductive system and reproductive functions; helps prevent atherosclerosis and cardiovascular diseases; normalizes metabolism and nervous system function; increases the body's defenses.

Pharmacokinetics

Retinol is absorbed in the gastrointestinal tract after emulsification with bile acids. Metabolized in the liver. Retinol metabolites are excreted in bile (retinyl palmitate, retinal, retinoic acid) and in urine (retinoyl glucuronide). Elimination of retinol is slow, cumulation is possible. Vitamin E: about 50% of the dose taken is slowly absorbed from the gastrointestinal tract, the maximum level in the blood is detected after 4 hours. Deposited in the adrenal glands, testes, adipose and muscle tissue, red blood cells, and liver. It is excreted from the body unchanged and in the form of metabolites with bile (over 90%) and urine (about 6%).

Special conditions

To avoid the development of hypervitaminosis A and E, do not exceed recommended doses. When using the drug, one should take into account the high content of vitamin A in it (100 thousand IU), and also that it is a therapeutic and not a preventive drug. A diet with a high content of Se and sulfur-containing amino acids reduces the need for vitamin E. Overdose Symptoms of acute overdose of retinol (vitamin A) (develop 6 hours after administration): hypervitaminosis A: in adults - drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration of the oral mucosa, peeling of the lips, skin (especially the palms), agitation, confusion. Symptoms of chronic intoxication with retinol (vitamin A): anorexia, bone pain, cracks and dry skin, lips, dry oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss hair, yellow-orange spots on the soles, palms, in the area of ​​the nasolabial triangle, hepatotoxic phenomena, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions; fetotoxic phenomena: in humans - malformations of the urinary system, growth retardation, early closure of epiphyseal growth zones; in animals - malformations of the central nervous system, spine, chest, heart, eyes, upper palate, genitourinary system. Symptoms of tocopherol (vitamin E) overdose: when taken for a long period in doses of 400-800 IU/day - blurred visual perception, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 IU/day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, disorders of sexual function, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, hemorrhage into the retina membrane of the eye, hemorrhagic stroke, ascites. Treatment: drug withdrawal; symptomatic therapy.

Compound

• 1 caps. retinol palmitate 0.055036 g (100000 IU) β-tocopherol acetate 0.1 g (100 IU) Excipients: sunflower oil - up to 0.2 g. Capsule shell composition: gelatin - 0.036913 g, glycerol - 0.011865 g, methyl parahydroxybenzoate - 0.0002 64 g, natural instant coffee - 0.000958 g. Alpha tocopherol acetate (vitamin E) 100 mg Retinol palmitate (vitamin A) * 100000 IU Excipients: Soybean oil up to 200 mg Shell composition in terms of absolutely dry matter: Gelatin 52.75 mg Glycerol 16 .80 mg Methyl parahydroxybenzoate 0.45 mg * Composition 1.7 million IU/g Vitamin A palmitate 990 mg dl-alpha-tocopherol acetate 10 mg alpha-tocopherol acetate (not less than 12 mg, retinol palmitate not less than 2.4 mg), sunflower oil, gelatin, glycerin, water. alpha-tocopherol acetate (not less than 12 mg, retinol palmitate (not less than 2.4 mg), sunflower oil, gelatin, glycerin, water. vitamin A (retinol palmitate, vitamin E (tocopherol acetate), auxiliary: soybean oil vitamin A, E, excipients: refined vegetable oil, citric acid, gelatin, glycerin, vitamin E (alpha-tocopherol acetate) 100 mg, vitamin A (retinol palmitate) 2.1 mg Excipients: flaxseed oil, antioxidant (ascorbyl palmitate, natural tocopherols, lecithin, rapeseed oil) The degree of satisfaction in vitamin A of the daily requirement is 262% (2.1 mg), which does not exceed the upper permissible level of consumption - 3 mg, in vitamin E - 670% (100 mg), which does not exceed the upper permissible level consumption – 150 mg. Nutritional value of 100 grams of product: proteins – 23.8 g, fats – 60.0 g, carbohydrates – 0.2 g, sugar alcohols – 12.1 g. Energy value of 100 grams of product: 665 kcal/2784 kJ Capsule shell: gelatin, glycerin, vitamin E (alpha-tocopherol acetate) 100 mg, vitamin A (retinol palmitate) 8600 IU, vegetable oil (sunflower or corn, soybean or olive), gelatin shell (gelatin, glycerol, preservative, coloring) ) . vitamin E, vitamin A, sunflower oil, gelatin shell. vitamin E (alpha-tocopherol acetate) 100 mg, vitamin A (retinol palmitate) 8600 IU, vegetable oil (sunflower or corn or olive) gelatin shell (gelatin, glycerol, preservative, coloring). main active ingredients: a-tocopherol acetate (vitamin E), retinol palmitate (vitamin A), sunflower oil Main components: a-tocopherol acetate (vitamin E), retinol palmitate (vitamin A), Auxiliary ingredients: unrefined olive oil, gelatin, glycerol retinol palmitate or retinol acetate (vitamin A) and alpha-tocopherol acetate (vitamin E). retinol palmitate or retinol acetate (vitamin A) and alpha-tocopherol acetate (vitamin E)., auxiliary: corn oil retinol palmitate (vitamin A) 100,000 IU, alpha-tocopherol acetate (vitamin E) 100 mg; mg content in 1 capsule. main active ingredients: a-tocopherol acetate (vitamin E) - 15 mg, retinol palmitate (vitamin A) - 0.9 mg, sunflower oil capsule: gelatin, glycerin (moisture-holding agent), nipagin-m (methylparaben - preservative)

Aevit indications for use

• Hypo- and avitaminosis A and E, as well as conditions of increased body need for vitamins A and E and/or decreased intake of them into the body: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, cirrhosis of the liver, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and colds), hemeralopia, xerophthalmia, keratomalacia, poor and unbalanced nutrition (including parenteral nutrition), rapid weight loss , nicotine addiction, drug addiction, alcoholism, a state of prolonged stress, taking cholestyramine, colestipol, mineral oils, neomycin, iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids, hyperthyroidism, pregnancy (including multiple pregnancy), lactation period. Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia. Efficacy has not been proven - atherosclerotic changes in blood vessels, impaired

Aevit contraindications

• Hypersensitivity, hypervitaminosis A and E, children's age (up to 14 years). With caution: thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (CHF, chronic glomerulonephritis, etc.), liver cirrhosis, viral hepatitis, renal failure, alcoholism, pregnancy (especially the first trimester), lactation, old age, childhood, hypoprothrombinemia (due to vitamin K deficiency - may increase with a dose of vitamin E more than 400 IU).

Aevit dosage

• - 0.2 g 200 mg 250 mg 330 mg

Aevit side effects

• With long-term use, large doses of vitamin A can cause symptoms of hypervitaminosis A (drowsiness, lethargy, headache, short-term fever, peeling of the skin, skin rashes, gait disorders, pain in the lower extremities). In rare cases, dyspeptic symptoms may occur in the form of a feeling of discomfort in the epigastric region, nausea, vomiting

Drug interactions

Retinol weakens the effect of calcium supplements and increases the risk of developing hypercalcemia. Cholestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (their dose may need to be increased). Oral contraceptives increase plasma concentrations of retinol. Isotretinoin increases the risk of developing retinol toxicity. The simultaneous use of tetracycline and retinol in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension. Tocopherol (vitamin E) enhances the effect of corticosteroids, NSAIDs, antioxidants, increases the effectiveness and reduces the toxicity of vitamins A, D, and cardiac glycosides. Prescribing vitamin E in high doses can cause vitamin A deficiency in the body. Tocopherol (vitamin E) increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood). Simultaneous use of vitamin E in a dose of more than 400 IU/day with anticoagulants (coumarin and indandione derivatives) increases the risk of developing hypoprothrombinemia and bleeding. The use of iron supplements in high doses increases oxidative processes in the body, which increases the need for vitamin E.

Overdose

Symptoms of acute overdose of vitamin A (develop 6 hours after administration): in adults - drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration of the mucous membrane of the cavity mouth, peeling of lips, skin (especially palms), agitation, confusion, increased intracranial pressure (in infants - hydrocephalus, protrusion of the fontanel). Symptoms of chronic vitamin A intoxication: anorexia, bone pain, cracks and dry skin, lips, dry oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow - orange spots on the soles, palms, in the area of ​​the nasolabial triangle, hepatotoxic phenomena, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions.

Storage conditions

• store in a dry place
• store in a cool place 5-15 degrees
• store at room temperature 15-25 degrees
• keep away from children
• store in a place protected from light

Information provided