Aertal or Nise which is better. Anti-inflammatory drugs for joints (NSAIDs): a review of drugs

The medicine also has an antipyretic effect. According to its chemical structure, the drug belongs to the group of coxibs.

The price of one capsule with a dosage of 100, 200 or 400 mg in Moscow pharmacies costs 50 rubles. The highest daily dose of the active substance (Celecoxib) is 400 mg and will cost 50–100 rubles. Celebrex is available in pharmacies with a doctor's prescription.

It is used to relieve or alleviate various types of pain, including post-operative, musculoskeletal, back pain, as well as for the symptomatic treatment of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis and primary dysmenorrhea.

More and more people are looking for something to replace their medicine - why?

By inhibiting COX-2 with little effect on COX-1, Celebrex effectively relieves pain and inflammation without causing significant harm to the gastrointestinal (GI) tract.

Although this drug is the least dangerous among coxibs in terms of the cardiovascular system (CVS), it still increases the risk of thrombotic events at a daily dose of more than 400 mg and with long-term use. For diseases of the cardiovascular system, the medication is contraindicated.

If we consider Celebrex from all sides, then today it is one of the safest NSAIDs, but very expensive, this is the first reason why many are looking for cheaper analogues of the drug.

Consumers are often afraid of possible side effects (mainly from the cardiovascular system) read from the instructions and do not start taking the medicine. However, those who have already taken it, as a rule, do not notice any dangerous side effects, but sometimes complain of poor effectiveness and a rapid decline in the effect when taken regularly.

Thus, Celebrex is one of the most expensive NSAIDs, which forces many people to look for alternatives.

All analogues of the drug - full review

As the closest analogue of Celebrex (based on the active substance - Celecoxib), Dilaxa is available for sale - capsules of 100 and 200 mg. Manufacturers: KRKA-RUS, KRKA.

Similar in chemical structure

Coxibs are selective COX-2 inhibitors. These include:

• Arcoxia (Etoricoxib) - tablets from Merck Sharp & Dohme B.V.
• Dynastat (Parecoxib) – lyophilisate from Pfizer

These drugs, like Celebrex, can provoke cardiovascular diseases and their complications.

Analogues according to indications and effects on the body

Medicines that, according to the instructions for use, are used in similar cases, namely for inflammation, as well as for joint and other pain.

Meloxicam - the main component - a selective inhibitor of COX-2, like celecoxib, belongs to oxicams, and can also increase the risk of thrombosis.

Contained in preparations:

• Movalis - injection solution, suppositories, suspension, tablets from Boehringer Ingelheim International;
• Amelotex - gel, injection solution, suppositories, tablets from the Sotex company;
• Artrosan – solution for injection, tablets from the company Pharmstandard-UfaVITA;
• Liberum – solution for injection, tablets from the company Farmak;
• Movasin – solution for injection, tablets from the Sintez company;
• Bi-xicam – solution for injection, tablets from the company Veropharm;
• Meloflex Rompharm is an injection solution from the company C.O. Rompharm;
• Mirlox - tablets from Grodzisk Pharmaceutical Works Polfa Co.

Nimesulide is a COX inhibitor, mainly COX-2. Refers to sulfonanilides. Preparations containing this substance:

• Nimesil – powder for preparing a suspension from the Guidotti/Menarini Group company;
• Nise – gel, tablets from Dr. Reddy_s Laboratories;
• Nemulex - granules for preparing a suspension from the Sotex company;
• Nimesan tablets from Shreya Life Sciences.

Non-selective COX inhibitors of different chemical structures have the same indications. They are often the most effective, but can damage the gastrointestinal mucosa.

TOP 18 best non-selective COX inhibitors that act similarly to Celebrex:

• Xefocam (Lornoxicam) – lyophilisate, tablets from the company Takeda, Nycomed;
• Texamen (Tenoxicam) - tablets from the company Mustafa Nevzat Ilac Sanayii;
• Neurodiclovit (Diclofenac, vitamins B1, B6, B12) – capsules from Lannacher Heilmittel;
• Naklofen (Diclofenac, Lansoprazole) – capsules from the KRKA company;
• Voltaren (Diclofenac) – injection solution, spray, suppositories, gel, tablets from Novartis;
• Diclak (Diclofenac) – gel, injection solution, suppositories, tablets from Hexal, Sandoz;
• Diclovit (Diclofenac) – gel, suppositories from the company NIZHFARM;
• Aertal (Aceclofenac) - cream, powder for suspension, tablets from the company Gedeon Richter;
• Indovazin (Indomethacin) – gel Indomethacin, Troxerutin from the Actavis Group;
• Indomethacin – gel, ointment, suppositories, tablets, capsules from the companies Biosintez, VetProm, Borisov Medical Preparations Plant, Atoll;
• Methindolretard (Indomethacin) – pills, ointment, injection solution from the ICN company;
• Ketanov (Ketorolac) – solution for injection, tablets from the Ranbaxy company;
• Ketorol (Ketorolac) – gel, solution for injection, tablets from the company Dr. Reddy_s Laboratories;
• Brustan (Ibuprofen, Paracetamol) – suspension, tablets from the Ranbaxy company;
• Ibuklin (Ibuprofen, Paracetamol) - tablets from the company Dr. Reddy's Laboratories;
• Deep Relief (Ibuprofen + Levomenthol) – gel from the company Mentholatum;
• Dolgit (Ibuprofen) – gel, cream from the company Dolorgiet;
• Strepsils (Flurbiprofen) - lozenges from Reckitt Benckiser Healthcare International.

Our choice

The best analogues that can replace Celebrex, taking into account consumer reviews, should be considered the following:

• Arcoxia;
• Voltaren (solution for injection);
• Dilaksa;
• Indomethacin;
• Ketanov;
• Xefocam;
• Movalis;
• Nise;
• Neurodiclovit;
• Piroxicam (capsules).

The most affordable analogues

Drugs based on Indomethacin, Diclofenac and Ibuprofen are available without a prescription. They are also the cheapest analogues of Celebrex:

1. Indomethacin. The highest daily dose (for long-term oral use – 75 mg) will cost from 3 rubles.
2. Diklak. The highest daily dose (150 mg) will cost from 10 rubles.
3. Ibuprofen. The highest daily dose (2400 mg) will cost from 10 rubles.

Domestic analogues

List of NSAIDs produced in Russia:

• Dilaxa (Celecoxib) from the company KRKA-RUS;
• Piroxicam-Akri from the Akrikhin company;
• Piroxyfer (Piroxicam) from the company Bryntsalov-A;
• Bi-xicam (Meloxicam) from Veropharm;
• Movasin (Meloxicam) from Eurocom;
• Oxycamox (Meloxicam) from Sandoz;
• Amelotex (Meloxicam) Sotex;
• Artrosan (Meloxicam) from Pharmstandard;
• Nemulex (Nimesulide) from Sotex;
• Diclovit (Diclofenac) from the company NIZHFARM;
• Indomethacin from the Biosintez company.

Disinterested opinion

We studied the reviews about Celebrex and its numerous analogues and this is the picture that emerges.

I am 60 years old. After surgery to remove my prostate this year, I took Celebrex. It lasts for 3 hours. Previously I took Ketorolac when I had severe pain in the kidneys due to stones. It is stronger and acts for 4 hours. Also, with an observation period of 1 year, Celecoxib does not differ from Diclofenac in terms of safety for the digestive system.

I used Nimesil and Celebrex. Not at the same time, of course. The first one acts faster. Serge

For some time, only Nise relieved my pain. The side effects made me look for something else. I settled on Movalis, it helps.

I have ankylosing spondylitis and intolerance to Sulfasalazine. I had to try different NSAIDs. Movalis, which I drank for 14 days in October, affected my digestive system. Then I took Nimesil, then Arcoxiu, and in December I tried Celebrex, 200 mg per day.

It seemed like this was what was needed. The pain and inflammation went away, and I didn’t notice any significant side effects on digestion. After a month and a half of taking it, the pain returned. They were stronger than 2-3 months ago, when I did not take anything.

I have a weak digestive system. From the old NSAIDs (non-selective COX inhibitors), I have bad bowel movements and severe stomach pain, even with stomach protectants (PPIs). I'm afraid to try Diclofenac. There are no obvious side effects only from Arcoxia (does not help) and Celebrex.

For 10 years I have been using Celebrex 2 times a day, 100 mg. If there is significant deterioration, I double the dose. Only the Pfizer drug is effective, especially the German one. The Russian analogue does not work. Arcoxia also has almost no effect and provokes gastric problems.

I use Ibuprofen twice a day. Unpleasant effects: severe asthenia, panic attacks. Nise and Aertal are not helping.

Celebrex does not relieve my back pain. The doctor prescribed Neurodiclovit, it works better and quite quickly.

Comparison with other drugs

Let's analyze what is better than Celebrex or its analogues based on price, side effects and other factors:

1. Arcoxia tablets. The highest daily dose (120 mg) will cost approximately 100 rubles. The highest concentration is achieved 1 hour after administration, that is, 2–3 times faster. The half-life is 22 hours, that is, 2-3 times longer (with repeated use of Celebrex). Thus, Arcoxia is absorbed faster, is present in the body longer and costs slightly more than Celebrex.
2. Movalis - tablets, injection solution, suppositories. The highest daily dose (15 mg) will cost from 40 rubles. The highest concentration is achieved after 4–5 hours, that is, 1.5–2 times slower. The half-life is 15–20 hours, that is, almost 2 times longer (with repeated use of Celebrex). Thus, Movalis is absorbed more slowly, but is present in the body longer, is less dangerous for the cardiovascular system, a little more dangerous for the gastrointestinal tract and is somewhat cheaper than Celebrex, and has more release forms.
3. Xefocam - tablets, lyophilisate. The highest daily dose (16 mg) will cost from 40 rubles. The highest concentration is achieved after 1–2 hours, that is, 1.5–2 times faster. Eating reduces the absorption of the drug by 30% and prolongs the absorption time to 3-4 hours. The half-life is on average 4 hours, that is, 2-3 times shorter. Thus, Xefocam is absorbed and eliminated from the body faster, is less dangerous for the cardiovascular system, a little more dangerous for the gastrointestinal tract and is somewhat cheaper, has more release forms.

Description of similar drugs Celebrex

Celebrex and analogs (generics) belong to the group of non-steroidal anti-inflammatory drugs (NSAIDs). The manufacturer of Celebrex is Physer, Germany.

Description of Celebrex

The drug acts as a selective inhibitor of type 2 cyclooxygenase (COX-2). Suppresses the synthesis of prostaglandins. According to its chemical structure, the drug belongs to the group of coxibs. The medication contains substances related to selective inhibitors of the synthesis of cytochrome cyclooxygenases. Thanks to them, the effect of the medicine is ensured. The main component is celecoxib in an amount of 100 or 200 mg.

The drug is used to relieve back pain, inflammation, and also for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and primary dysmenorrhea. In addition, the medicine has an antipyretic effect.

Today, Celebrex is one of the safest NSAIDs, but due to the high price, it is often necessary to use analogues.

The cost of the drug, depending on the dose of the active substance, is in the range of 160–950 rubles.

List of analogues

Celebrex has analogues both Russian and foreign. The following medications are generics in terms of active substance and pharmacological action:

Dilaksa

The drug is manufactured by KRKA (Slovenia). The main component is celecoxib. Auxiliary components - magnesium stearate, croscarmellose sodium. Available in capsules filled with white granular powder. Dosage - 100 or 200 mg.

The cost of the drug is 200–450 rubles, depending on the dose of the active substance and the pharmacy.

The medication's indications are the same as Celebrex. Contraindications include: condition after coronary artery bypass grafting, erosion and ulcers of the duodenum and stomach, intestinal inflammation in the acute stage, heart failure, pregnancy and lactation, renal and liver failure, age under 18 years, intolerance to one of the components of the drug.

Dilaxa has the following side effects:

• increased blood pressure;
• tachycardia;
• arrhythmia;
• myocardial infarction;
• ischemic stroke;
• diarrhea;
• flatulence;
• nausea;
• vomit;
• insomnia;
• dizziness;
• cough;
• itchy skin;
• rash.

When Dilaxa and anticoagulants were used together, severe bleeding was observed.

Zitsel

The medicine is produced in India. The main active ingredient is celecoxib. Dispensed from pharmacies without a doctor's prescription. Price - about 200 rubles. Replaces Celebrex to eliminate back pain, joint pain, menstrual pain, and for the treatment of colorectal polyps. You need to take medication capsules 2 times a day, regardless of meals. The dosage is prescribed by the doctor. Contraindications are the same as for Dilaxa.

Side effects include: diarrhea, flatulence, nausea, dizziness, swelling, leg cramps, itching, headache, etc.

Artoxib

The medicine is also produced in India and is one of the most popular and effective medicines for joints. Available in capsule form. Take 1 time per day after meals. Indications and contraindications for use are the same as for Celebrex.

Bextra

The active ingredient in Bextra is valdecoxib. This is not the best option to replace Celebrex since the prices are about the same. In addition, this medication has many contraindications and side effects. Available in tablet form, you can take the drug regardless of meals.

Arcoxia

Arcoxia is produced in Spain and the Netherlands. Available in tablet form. The active substance is etoricoxib. Auxiliary components - magnesium stearate, calcium hydrogen phosphate, microcrystalline cellulose. Etoricoxib does not suppress the production of gastric prostaglandins and does not affect platelet function. Most of the medication is excreted in the urine. The half-life is 22 hours. The medication has fewer side effects than Celebrex.

The drug shell contains lactose, this must be taken into account when prescribing to people intolerant to this component. Can be taken with or without food, with a small amount of water. During treatment you should stop drinking alcohol. Arcoxia can be used in the treatment of pregnant women if the benefit to the mother outweighs the possible risk to the fetus. The price of the drug is not the lowest; in some pharmacies Celebrex may cost less.

Dynastat

Contains parecoxib sodium as the active substance. Auxiliary components - phosphoric acid, sodium hydroxide. Used for injection, the package contains a tablet or porous mass and a solvent. The medication does not affect the mucous membrane of the stomach and intestines. The half-life of the drug is 22 minutes.

Dynastat is prescribed to relieve pain during the postoperative period. Contraindications include: bronchospasm, urticaria, allergy to acetylsalicylic acid, 3rd trimester of pregnancy, lactation period, severe heart and liver failure. The dose of the drug is prescribed by the doctor individually for each patient. The price of the medicine can reach 2500 rubles.

Cheap analogues

Based on their therapeutic effect, you can choose cheap substitutes for Celebrex. For example:

• Diclofenac;
• Ibuprofen;
• Meloxicam;
• Flamax;
• Amelotex.

Meloxicam

The cost of Meloxicam is from 70 rubles, depending on the dosage and the pharmacy dispensing the drug. The active ingredient of the drug is meloxicam. Auxiliary components - magnesium stearate, starch, sodium dihydrate, silicon dioxide. The medication is available in the form of tablets, suppositories, and injection solutions. Belongs to the group of NSAIDs. The effect of the drug is similar to Celebrex. The peculiarity of Meloxicam is that it acts selectively, only at the site of inflammation, therefore it extremely rarely causes ulcerative and erosive lesions of the gastrointestinal tract.

Injections and suppositories have a rapid therapeutic effect. However, suppositories are still an emergency measure when it is not possible to take a pill or give an injection. Long-term use of suppositories can cause damage to the rectal mucosa and constipation. The medication is prescribed for rheumatoid arthritis, osteoarthritis, and inflammatory joint diseases accompanied by acute pain. The drug is not used during pregnancy and lactation, renal pathologies, or intolerance to NSAID drugs.

While taking Meloxime, side effects may occur: headaches, nausea, vomiting, rashes and itching of the skin, rapid heartbeat.

Diclofenac

It is an anti-inflammatory, antipyretic, analgesic medication. The active ingredient is sodium diclofenac. The medicine is a derivative of phenylacetic acid. Prescribed for diseases of the musculoskeletal system, after surgery and injury, and for damage to peripheral nerves.

Diclofenac tablets relieve pain for a long time. The main contraindications include pregnancy and lactation, age under 6 years, and recent coronary artery bypass surgery.

Possible side effects: dizziness, irritability, disturbances in the gastrointestinal tract. The cost of the drug starts from 15 rubles.

Ibuprofen

It is a non-narcotic analgesic and belongs to the group of NSAIDs. It exhibits pronounced anti-inflammatory activity, eliminates fever and pain, so the medication is used for inflammatory diseases of the musculoskeletal system. The drug is available in the form of tablets, capsules, gel, oral suspension, and suppositories. To relieve pain, the medication is used once, to relieve inflammation - for a short course, for the treatment of chronic diseases - for a long time.

In the form of ointments and gels, the drug is used externally, the course of treatment is 2–3 weeks. Rub the product into the affected area 3-4 times a day. The medicine is taken in tablets and capsules during meals. Tablets are prescribed for symptomatic therapy; Ibuprofen does not affect the progression of diseases. Contraindications and side effects are the same as for Celebrex. The cost of the drug, depending on the dosage of the active substance and the release form, starts from 15 rubles.

Flamax

The medicine has antipyretic, anti-inflammatory, antiaggregation, analgesic effects. The active substance is ketoprofen, metabolized in the liver. The medication is used for symptomatic therapy. Available in the form of capsules and solutions for intramuscular and intravenous injections. Indications and contraindications for use are the same as for Celebrex. The price of the drug is from 95 rubles.

Conclusion on the topic

Celebrex has many analogues, but the doctor must tell you which one can be replaced. Under no circumstances should you self-medicate, since almost all medications similar to Celebrex have many contraindications and cause serious side effects that can lead to irreparable consequences.

Celebrex - instructions for use, analogs, reviews and release forms (capsules or tablets 100 mg and 200 mg) of a drug for the treatment of pain due to arthrosis and arthritis in adults, children and pregnancy. Composition and interaction with alcohol

In this article you can read the instructions for use of the drug Celebrex. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Celebrex in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Celebrex in the presence of existing structural analogues. Use for the treatment of pain due to arthrosis and arthritis in adults, children, as well as during pregnancy and breastfeeding. Composition and interaction of the drug with alcohol.

Celebrex is a non-steroidal anti-inflammatory drug (NSAID). Celecoxib (the active ingredient of the drug Celebrex) has anti-inflammatory, analgesic and antipyretic effects, blocking the formation of inflammatory prostaglandins mainly due to inhibition of COX-2. Induction of COX-2 occurs in response to the inflammatory process and leads to the synthesis and accumulation of prostaglandins, especially prostaglandin E2, with increased manifestations of inflammation (swelling and pain). In therapeutic doses in humans, celecoxib does not significantly inhibit COX-1 and has no effect on prostaglandins synthesized as a result of activation of COX-1, and also does not affect the normal physiological processes associated with COX-1 and occurring in tissues, and above all in the tissues of the stomach, intestines and platelets.

Effect on kidney function. Celecoxib reduces the urinary excretion of prostaglandin E2 and 6-keto-prostaglandin F1 (a metabolite of prostacyclin), but does not affect serum thromboxane B2 or the urinary excretion of 11-dehydro-thromboxane B2, a metabolite of thromboxane (both COX-1 products). Celecoxib does not cause a decrease in glomerular filtration rate in elderly patients and patients with chronic renal failure; it transiently reduces sodium excretion. In patients with arthritis, the observed incidence of peripheral edema, hypertension and heart failure is comparable to that observed with non-selective COX inhibitors, which have inhibitory activity against COX-1 and COX-2.

Celecoxib + excipients.

When taken on an empty stomach, Celebrex is well absorbed. The absolute bioavailability of the drug has not been studied. Effect of food: Taking celecoxib with a fatty meal increases the time to Cmax by approximately 1-2 hours and increases complete absorption by approximately 20%. Plasma protein binding is independent of concentration and is about 97%; celecoxib does not bind to red blood cells. Penetrates the blood-brain barrier (BBB). Celecoxib is metabolized in the liver, excreted in feces and urine in the form of metabolites (57% and 27%, respectively), less than 3% of the dose taken is unchanged.

• symptomatic treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis;
• pain syndrome: back pain, musculoskeletal, postoperative and other types of pain;
• treatment of primary dysmenorrhea.

Capsules 100 mg and 200 mg (sometimes mistakenly called tablets).

There are no other dosage forms, be it injections in injection ampoules or suppositories.

Instructions for use and dosage

The drug is taken orally, regardless of food intake; the capsules are not chewed, washed down with water.

Since the risk of possible cardiovascular complications may increase with increasing dose and duration of use of Celebrex, it should be prescribed in the shortest possible courses and at the lowest recommended doses. The maximum recommended daily dose for long-term use is mg.

For the symptomatic treatment of osteoarthritis, the recommended dose is 200 mg per day in 1 or 2 doses. The safety of taking the drug in doses of up to 400 mg 2 times a day was noted.

For the symptomatic treatment of rheumatoid arthritis, the recommended dose is 100 mg or 200 mg 2 times a day. The safety of taking the drug in doses of up to 400 mg 2 times a day was noted.

For the symptomatic treatment of ankylosing spondylitis, the recommended dose is 200 mg per day in 1 or 2 divided doses. If necessary, the dose can be increased to 400 mg per day.

For the treatment of pain and primary dysmenorrhea, the recommended initial dose is 400 mg, followed, if necessary, by an additional dose of 200 mg on the 1st day. In subsequent days, the recommended dose is 200 mg 2 times a day (as needed).

Elderly patients usually do not require dose adjustment. However, in patients weighing less than 50 kg, it is better to start treatment with the lowest recommended dose.

In patients with mild hepatic insufficiency (class A on the Child-Pugh scale), no dose adjustment is required; in case of moderate hepatic insufficiency (class B on the Child-Pugh scale), treatment should begin with the minimum recommended dose.

In patients with mild to moderate renal impairment, no dose adjustment is required. There is no experience with the use of the drug in patients with severe renal failure.

For patients taking fluconazole (a CYP2C9 inhibitor), Celebrex should be administered at the minimum recommended dose.

• exacerbation of allergic diseases;
• flu-like syndrome;
• accidental injuries;
• peripheral edema;
• diarrhea;
• dyspepsia;
• vomit;
• flatulence;
• stomach and duodenal ulcers;
• intestinal perforation;
• gastrointestinal bleeding;
• dental diseases (post-extraction alveolitis);
• dizziness;
• insomnia;
• drowsiness;
• confusion;
• hallucinations;
• urinary tract infection;
• acute renal failure;
• interstitial nephritis;
• bronchitis;
• cough;
• pharyngitis;
• rhinitis;
• sinusitis;
• upper respiratory tract infections;
• skin itching;
• skin rash;
• hives;
• anaphylaxis;
• angioedema;
• anemia, ecchymosis, thrombocytopenia;
• worsening of arterial hypertension;
• increased blood pressure;
• arrhythmia;
• tides;
• heartbeat;
• tachycardia;
• noise in ears;
• blurred vision;
• loss of taste;
• loss of smell;
• vasculitis;
• hemorrhages in the brain;
• photosensitivity;
• peeling of the skin (including with erythema multiforme and Stevens-Johnson syndrome);
• toxic epidermal necrolysis;
• menstrual irregularities;
• pulmonary embolism;
• chest pain.

• bronchial asthma, urticaria or allergic reactions after taking acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs (NSAIDs), including other COX-2 inhibitors;
• condition after coronary artery bypass surgery;
• peptic ulcer in the acute phase;
• gastrointestinal bleeding;
• inflammatory bowel diseases;
• heart failure (2-4 functional classes according to the NYHA classification);
• clinically confirmed ischemic heart disease;
• peripheral arterial diseases and severe cerebrovascular diseases;
• severe liver failure (no experience with use);
• severe renal failure (no experience with use);
• pregnancy;
• lactation period (breastfeeding);
• age under 18 years (no experience of use);
• hypersensitivity to the components of the drug;
• hypersensitivity to sulfonamides.

Use during pregnancy and breastfeeding

Clinical experience with the use of celecoxib during pregnancy is limited. The potential risk of using Celebrex during pregnancy has not been established, but cannot be excluded. Celecoxib, which is an inhibitor of prostaglandin synthesis, when taken during pregnancy, especially in the 3rd trimester, can cause weakness of uterine contractions and premature closure of the ductus arteriosus.

There is limited evidence that celecoxib is excreted in breast milk. Taking into account the potential for side effects when taking celecoxib in a breastfed child, the advisability of continuing breastfeeding should be assessed, taking into account the importance of taking Celebrex for the mother.

Contraindicated in children under 18 years of age (no experience with use).

Celecoxib (like all coxibs) may increase the risk of serious cardiovascular complications such as blood clots, myocardial infarction and stroke, which can lead to death. The risk of these reactions may increase with the duration of drug use, as well as in patients with diseases of the cardiovascular system. To reduce the risk of these reactions in patients taking Celebrex, it should be administered at the lowest recommended doses and for the shortest periods possible. The attending physician and patient should be aware of the possibility of such complications even in the absence of previously known cardiovascular symptoms. Patients should be informed of the signs and symptoms of adverse cardiovascular effects and measures to take if they occur.

Celecoxib (as well as other NSAIDs) should be used with caution in patients with arterial hypertension. At the beginning of therapy with Celebrex, as well as during the course of treatment, blood pressure should be regularly monitored.

Effect on the gastrointestinal tract. Extremely rare cases of perforation, ulceration and bleeding from the gastrointestinal tract have been observed in patients taking celecoxib. The risk of developing these complications during treatment with NSAIDs is highest in elderly patients with cardiovascular diseases, in patients simultaneously receiving acetylsalicylic acid, and in patients with ulcerative lesions of the gastrointestinal tract, bleeding in the acute stage and a history. Most spontaneous reports of serious gastrointestinal side effects were in elderly and debilitated patients.

Combined use with warfarin and other anticoagulants. Serious, and some fatal, bleeding has been reported in patients receiving concomitant treatment with warfarin or similar agents. Since an increase in prothrombin time has been reported, anticoagulant activity should be monitored after initiating treatment with Celebrex or changing its dose.

Fluid retention and swelling. As with other drugs that inhibit prostaglandin synthesis, some patients taking Celebrex may experience fluid retention and edema, so caution should be used when prescribing this drug to patients with conditions predisposing or worsened by fluid retention. Patients with a history of heart failure or hypertension should be closely monitored.

Effect on kidney function. Celebrex should be used with caution in patients with impaired renal function. Renal function in such patients should be carefully monitored.

Celebrex should be administered with caution to patients with dehydration. In such cases, it is advisable to first rehydrate and then begin Celebrex therapy.

Effect on liver function. Celebrex should be used with caution in the treatment of patients with moderate hepatic impairment and should be prescribed at the lowest recommended dose. In some cases, severe liver reactions have been observed, including fulminant hepatitis (sometimes fatal), liver necrosis (sometimes fatal or the need for liver transplantation). Most of these reactions occurred 1 month after starting celecoxib. Patients with symptoms of liver dysfunction, or in cases where liver dysfunction is detected by laboratory tests, require close monitoring for timely diagnosis of more severe liver reactions during treatment with Celebrex.

Anaphylactic reactions. Cases of anaphylactic reactions have been reported while taking Celebrex.

Celebrex, given its antipyretic effect, can reduce the diagnostic significance of a symptom such as fever and affect the diagnosis of infection.

In extremely rare cases, serious skin reactions, such as exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis, some of them fatal, have been reported with celecoxib. The risk of such reactions occurring in patients at the beginning of therapy is higher; in most reported cases, such reactions began in the first month of therapy. Stop taking Celebrex if you experience skin rash, changes in mucous membranes, or other signs of hypersensitivity.

Impact on the ability to drive vehicles and operate machinery

The effect of celecoxib on the ability to drive vehicles and operate machinery has not been studied. Based on the pharmacodynamic properties and overall safety profile, it appears unlikely that Celebrex has such an effect.

Studies have shown that celecoxib, although not a substrate of CYP2D6, inhibits its activity. Therefore, there is a possibility of drug interaction with drugs whose metabolism is associated with cytochrome CYP2D6.

When taken simultaneously with warfarin and other anticoagulants, an increase in prothrombin time is possible.

Drinking alcohol enhances and increases the likelihood of side effects of Celebrex on the body (especially gastrointestinal bleeding).

In patients taking fluconazole (a CYP2C9 inhibitor), celecoxib should be prescribed at the lowest recommended dose; ketoconazole (a CYP3A4 inhibitor) does not have a clinically significant effect on the metabolism of celecoxib.

Inhibition of prostaglandin synthesis may reduce the effect of ACE inhibitors and angiotensin 2 antagonists. This interaction should be taken into account when prescribing celecoxib with ACE inhibitors/angiotensin 2 antagonists. However, there was no significant pharmacodynamic interaction with lisinopril in terms of the effect on blood pressure.

Previously known nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the natriuretic effect of furosemide and thiazides in some patients by inhibiting renal prostaglandin synthesis; this should be kept in mind when prescribing celecoxib.

There was no clinically significant effect of celecoxib on the pharmacokinetics of combined contraceptive products containing 1 mg norethisterone/35 mcg ethinyl estradiol).

There was an increase in plasma lithium concentrations of approximately 17% when lithium and celecoxib were coadministered. Patients receiving lithium therapy should be closely monitored when initiating or discontinuing celecoxib.

There were no clinically significant interactions between celecoxib and antacids (aluminum- and magnesium-containing drugs), omeprazole, methotrexate, glibenclamide, phenytoin or tolbutamide.

Celebrex does not affect the antiplatelet effect of acetylsalicylic acid, so it cannot be considered as a replacement for acetylsalicylic acid prescribed for the prevention of cardiovascular diseases.

Other NSAIDs. The simultaneous use of celecoxib with other NSAIDs (not containing acetylsalicylic acid) should be avoided.

Analogues of the drug Celebrex

Structural analogues of the active substance:

Analogues in terms of their therapeutic effect (medicines for the treatment of joint pain):

Cheap analogues and substitutes for the drug Celebrex: list with prices

The active ingredient of this medicine is celecoxib. This is a drug from the group of new generation NSAIDs, which has anti-inflammatory, antipyretic and analgesic activity.

Ulcerogenic activity (the risk of developing ulcers) is minimized - this is the advantage of Celebrex.

The list of contraindications is quite long, in particular, Celebrex cannot be used during pregnancy, lactation, under 18 years of age, a number of diseases of the gastrointestinal tract, kidneys, liver and hematopoietic system.

Like many imported drugs (it is produced by Pfizer), Celebrex is quite expensive.

The price ranges from 400 to 600 rubles, in some pharmacies it may be higher, so there is a need to replace it with a cheap analogue. But finding cheap analogues of the drug can be difficult.

Russian-made analogues

There are no analogues of Celebrex from a completely domestic manufacturer. These drugs are almost entirely imported into our country from abroad.

The medicine contains celecoxib. The drug is produced by the Slovenian company KRKA, one of whose factories is in the Moscow region.

Most of the Dilax drug on the domestic market is Russian-made under license from KRKA. In terms of its features, Dilaxa is close to Celebrex, but slightly lower in price. The cost is rub.

Ukrainian substitutes

There are Ukrainian-made analogues of Celebrex, which are produced under license from foreign companies (the same as Dilax). There are no analogues completely developed and produced in Ukraine.

Belarusian generics

Just like in Ukraine, Belarus does not have its own production of analogues of Celebrex. Some Belarusian enterprises are engaged in packaging and production of celecoxib drugs under a foreign license.

Other foreign analogues

Generics are drugs that have the same composition as the original drugs, but are produced at other pharmaceutical plants and have a lower price.

The production of generic drugs is certified by the plant producing the original drug. The price is lower due to the fact that the generic manufacturer buys ready-made technology without investing in the development of the drug.

Their prices can be even lower if you order from online pharmacies with delivery. The main producing countries of such generics are India and Egypt.

Such drugs include:

Drug Zitsel, India. The active ingredient is celecoxib. It has the same indications, contraindications and side effects as the original product.

Sold without a prescription, the price is about 200 rubles. Prescribed for joint diseases, back pain, painful menstruation, and for the treatment of colorectal polyps.

Arthroxib, India. Another inexpensive analogue of Celebrex. Included in the list of the most popular and effective medicines for joints.

The active ingredient is celecoxib, indications are diseases of the joints and spine, painful periods. In cost it can compete with Zitsel; these drugs can be considered equivalent.

In addition to drugs that contain the same active substance (synonymous drugs), medications are used that contain active principles that are similar in their properties - NSAIDs of the coxib group.

Bextra. The active ingredient is valdecoxib. Indications are similar to Celebrex - diseases of the joints, spine, acute pain syndrome, algodismenorrhea.

Not the best choice if the question arises of how to replace Celebrex - the drugs are comparable in price. It has a fairly long list of contraindications and side effects.

Arcoxia (Netherlands, Spain). Contains etoricoxib. It is considered a safer drug than Celebrex, because. has fewer side effects.

Below is a table listing modern drugs from the coxib group that can be considered analogues of Celebrex.

Their names, countries of origin, and average prices for them are indicated:

"Celebrex": reviews, indications, instructions, composition, analogues

Today, pharmacies offer their customers a huge variety of anti-inflammatory and analgesic drugs. The drug Celebrex is no exception. You can read reviews about this medication, as well as a description, instructions for use, indications, contraindications and analogues in this article.

Composition and release form

The drug "Celebrex", reviews of which you can read on this resource, is in the form of capsules that are intended for internal use. The active ingredient of this medication is celecoxib. Each capsule contains one hundred or two hundred milligrams of the active element. In addition, the composition can also contain such auxiliary components as magnesium stearate, croscarmellose sodium and lactose.

Capsules are placed in blisters, ten in each. One cardboard package contains one blister.

Pharmacology

The drug "Celebrex", reviews of which are positive, has anti-inflammatory, as well as antipyretic and analgesic effects on the body. The medication has such an effect on the human body due to the ability of the active component included in its composition to block the formation of prostaglandins.

During treatment with this drug, experts do not recommend eating fatty foods, as this will cause the active component of the drug to be absorbed much longer.

The drug "Celebrex", the composition of which is described above, is almost completely eliminated from the body through the stomach and kidneys.

In what cases can it be used?

In fact, this drug has a very wide range of uses due to its anti-inflammatory and analgesic effect.

With the development of diseases of the musculoskeletal system. Especially for rheumatoid arthritis and osteoporosis.

The drug will also cope well with pain caused by bone tissue injuries and after surgery.

Doctors draw patients' attention to the fact that this drug is used as a method of symptomatic therapy. It will not affect the course of the disease itself in any way.

"Celebrex." Instructions for use

Since the medicine is available in the form of capsules, they must be taken orally with plenty of purified water. In this case, you can take the drug at any time of the day, regardless of your diet. Of course, you can read about the specifics of the dosage in the instructions for use, but it is best if your attending physician selects it for you individually, taking into account all the characteristics of your body and the course of the pathology.

Please note that the drug should be used very carefully by those people who suffer from improper metabolism, as this can lead to more serious complications. It is also worth paying attention to the fact that the active components included in the medicine can accumulate in the body and thus lead to side effects.

Are there any contraindications for use?

The instructions for use for Celebrex tablets do not recommend using the drug in all cases.

Under no circumstances should this medicine be used by pregnant and lactating women, as well as by patients who have an excessive allergic reaction to the components included in the composition. Also, the product should not be used in the presence of diseases such as bronchial asthma, peptic ulcers, serious diseases of the cardiovascular system, bleeding in the gastrointestinal tract, as well as serious pathologies of the kidneys and liver.

Under the special supervision of a doctor, Celebrex tablets can be used for those patients who are prone to swelling, and also have diseases of the digestive system and diabetes.

Do not self-medicate under any circumstances. You can use this medication only if it has been prescribed to you by your doctor.

Formation of side effects

Illiterate use of any medicine can lead to side effects. And the painkiller Celebrex is no exception. In fact, this medicine is quite dangerous and can lead to side effects in all organs and organ systems of the body.

So, most often patients complained of the development of side effects from the digestive system. The patients suffered from nausea, vomiting and abdominal pain. Some patients noticed that after taking the pill they began to feel dizzy, feel weak and faint.

Some patients began to complain of deteriorating hearing and vision, as well as the occurrence of infectious processes in the genitourinary system. It is also worth considering the occurrence of allergic reactions, kidney and liver failure.

If the patient notices the presence of any of the side effects listed above, he urgently needs to tell the doctor about it. In this case, he must reduce the dosage or choose another drug.

Use during pregnancy

The instructions for use do not recommend the use of Celebrex capsules for pregnant women. However, in some cases, doctors still make exceptions. If we take into account the fact of how this medicine works, we can conclude that it can lead to changes in the ovaries, which will cause serious complications during pregnancy and during childbirth.

If you use this medicine in the third trimester of pregnancy, this may cause the uterus to contract very weakly. It can also cause the ducts arteriosus to close.

Also, every woman should take into account that the active component of the drug Celebrex, reviews of which are largely positive, will be excreted along with breast milk, which will be extremely dangerous for the baby. Therefore, it is also not recommended to use this drug during the breastfeeding period. If it is impossible to stop taking capsules, then it is worth considering the possibility of switching the child to artificial feeding.

Interaction with other drugs

The instructions for use recommend using Celebrex capsules very carefully. This is especially true for simultaneous use with anticoagulants. This especially includes those medications that were made on the basis of warfarin. In medical practice, cases of the development of excessively intense bleeding while taking these medications have been recorded. Some of them were fatal, so you should be as careful as possible.

Also, Celebrex tablets are not intended to replace corticosteroids. Patients suffering from dehydration or taking diuretics sometimes notice a deterioration in the functioning of the genitourinary system. If you use the drug "Celebrex" together with drugs containing ketoconazole, then be prepared for the fact that the amount of the active component in the blood plasma will be increased several times.

Important instructions for use

The drug Celebrex, the indications for which are described above, according to patients and doctors, is a very effective remedy, but sometimes taking it can lead to the development of some complications. Therefore, before taking this medication, be sure to consult your doctor.

Since Celebrex tablets are an antipyretic, taking them sometimes makes it very difficult to detect a hidden infection in the body.

You should also not forget that the active component included in the Celebrex capsules can affect the cardiovascular system and lead to the development of complications such as myocardial infarction or an increase in blood clots. Moreover, the longer you use this drug, the greater the likelihood of developing such side effects.

The highest risk group includes those patients who suffer from heart and vascular diseases at the time of taking the drug. In order to minimize the risk of developing cardiovascular pathologies, Celebrex should be used in very small dosages and for a short period of time.

Even if you have the slightest suspicion of adverse reactions, go to the hospital immediately and tell your doctor about it.

If Celebrex tablets, contraindications for which are given in this article, are used after a procedure such as bypass surgery, then there may be a huge risk of developing myocardial infarction or cerebrovascular accident.

Celebrex and alcohol: compatibility

In fact, doctors categorically prohibit the consumption of alcoholic beverages during treatment with Celebrex tablets.

Such a dangerous combination will cause irreparable harm to your body and can even be fatal. So, let's take a closer look at what the combination of two incompatible components can lead to:

• Serious liver problems. Drinking alcohol may prevent the drug from being metabolized. And this, in turn, can lead to both damage to the organ itself and poor blood purification of the active component, which will cause an overdose.
• Formation of ulcers in the stomach. Alcohol can greatly irritate the gastric mucosa, as a result of which it will become defenseless to the action of other negative factors. Severe ulcerative damage to the stomach and intestines can lead to internal hemorrhages, which can be fatal.
• Also, patients taking alcohol and Celebrex tablets at the same time have a very strong effect on the cardiovascular system. The combination of two incompatible substances significantly increases the risk of heart attack and stroke.

Please note that drinking alcohol during treatment with this drug is strictly prohibited, so avoid alcoholic beverages during treatment. So the effect of taking this medicine will be much higher, and there will be much fewer side effects.

Are there analogues

Like any other drug, Celebrex capsules and substitutes are available. Analogues are products that have a similar composition and have the same effect on the body. Let's consider the drugs that are prescribed by doctors most often for joint pain, as well as in the presence of inflammatory processes in the body: "Mirlox", "Artrosan", "Nise", "Nimesan", "Xefocam", "Diklak", "Indovazin", " Ketanov", "Dilaksa", "Voltaren".

The medications listed above are the most popular substitutes for a drug such as Celebrex. You can easily buy analogues at any pharmacy, but before doing so, be sure to consult with your doctor.

Celebrex can be replaced with medications that include ibuprofen, indomethacin and diclofenac. Medicines made from these ingredients have the lowest cost.

A very large number of people suffer from such an unpleasant disease as intercostal neuralgia. This disease is caused by compression or irritation of the nerves passing between the ribs. The main symptom of this pathology is excruciating and intense pain, which intensifies with deep breathing, coughing and movement. It is worth noting that intercostal neuralgia, drug treatment for which can only be prescribed by a qualified general practitioner or neurologist, is a fairly serious disease.

If a person experiences severe pain in the intercostal area, then he needs to consult an experienced doctor. Indeed, under the mask of this disease, completely different pathologies may be hidden. For example, it could be a heart disease or renal colic. The doctor, after conducting the necessary examination, will be able to prescribe the correct treatment, which will help the patient quickly return to work and normal life.

Self-medication can be dangerous - almost all drugs have a lot of contraindications and various side effects, and in this disease, drugs cannot always completely eliminate pain. Only a qualified specialist can determine which drugs and in what dosage form are suitable for a particular patient, and also prescribe the required duration of drug therapy.

For medication to be effective, general recommendations should be followed. So, approximately in the first three days of illness, when the pain is especially severe, it is better for the patient to refrain from going to work and stay in bed. You need to lie on a shield, that is, on a very flat and hard surface. You should also give up high pillows.

Painkillers – effective treatment in a variety of forms

Of course, first of all, the patient needs drugs that can relieve him of pain. For this purpose, non-steroidal anti-inflammatory drugs are usually used. There is a huge range of such medications in pharmacies, but you should not buy them yourself or on the recommendations of a pharmacist. Only a doctor can prescribe the appropriate drug.

As a rule, for very severe pain, doctors prescribe intramuscular injections of painkillers such as Ketonal, Ketorol or Analgin. All of them relieve pain very quickly, although the effect lasts only a few hours. The doctor usually prescribes a whole course of such injections - five or ten procedures. Such medications cannot be used for a longer period of time, as they can cause exacerbation of stomach diseases, for example, ulcers or gastritis.

Sometimes drugs such as Ketonal can also be prescribed in the form of rectal suppositories. This dosage form is quite acceptable for elderly patients, as it provides long-term pain relief and acts quickly.

Non-steroidal anti-inflammatory drugs are also used in the form of ointments or gels. These may be drugs such as Nise, Ketonal, Diclofenac, Voltaren. A small amount of ointment is applied in a thin layer to the area of ​​the body where pain is felt. As a local treatment, patches with a medicinal substance applied to them are sometimes used, for example, Ketonal thermo. According to the doctor’s recommendation, such a patch can be applied to the sore spot at night.

The doctor may prescribe painkillers in tablet form. These could be medications such as Analgin, Nise, Movalis or Baralgin. They are usually taken three times a day after meals, adhering to the recommended dose. The course of such treatment, as a rule, is not long, since long-term use of these drugs can cause serious health problems, primarily with the gastrointestinal tract. There are also more modern medicines that have a prolonged (that is, long-lasting) effect. These include, for example, Melox forte, which is enough to take only once a day.

Vitamins will help cope with neuralgia

Vitamins for a disease such as intercostal neuralgia must be taken. This is especially true for B vitamins such as B6, B1 and B12. Many experienced doctors prescribe intramuscular injections of these medications to patients. Injections of vitamins B1 and B6 must be alternated, for example, inject B1 on even days, and B6 on odd days. Sometimes doctors advise patients to take multivitamins instead of injections.

Novocaine blockade - quick relief of pain

Sometimes, to relieve acute pain, a neurologist can give his patient a novocaine blockade. This method allows the patient to get rid of unpleasant sensations very quickly. It consists of injecting the affected nerve with novocaine. True, this procedure is not recommended for everyone.

Medicines containing snake and bee venoms

Medicines that contain bee or snake venom are also quite effective. But they also have contraindications: liver and kidney diseases, lactation, pregnancy, heart disease, fever or individual intolerance to the components. You can use such medications only after consulting your doctor.

Drugs whose action is based on bee venom include an ointment called Apizartron. They make it in Germany. It has not only an analgesic, but also an anti-inflammatory effect.

The ointment, which is called Viprosal, contains viper venom. It is used externally and helps relieve pain and inflammation. It also contains components such as camphor and fir oil, which are also quite effective for neuralgia.

Other medications will enhance the effect of treatment

Less commonly, muscle relaxants and tranquilizers are used for intercostal neuralgia. These drugs help relieve muscle spasms, calm the patient, and give him the opportunity to relax and unwind. Doctors usually use Sibazon in tablets; in more severe cases, Relanium is administered intramuscularly. Only a doctor has the right to prescribe such drugs, since they are sold strictly according to a prescription. Muscle relaxants can also reduce the severity of pain, but the side effects of the drugs determine the need for medical supervision of the therapy.

Pepper plaster is often used to relieve pain. It is glued to the painful area, and the skin must be dry, clean and without any damage. A contraindication for this method is an allergy to the components of the patch.

So, it is, of course, worthwhile to be treated for intercostal neuralgia. In order to regain your health as soon as possible, you must strictly adhere to the recommendations given by your doctor. After all, self-medication can lead to much more serious diseases than neuralgia.

Anti-inflammatory drugs for arthrosis and arthritis of the joints

What are the most effective anti-inflammatory drugs for joint diseases? What are their benefits, and are they harmful? How do these medications affect the disease and condition of the joints, as well as the body as a whole? This is what we will talk about in this article.

Warning: self-medication can harm your body! Take only medications prescribed by your doctor. Before using any medications, be sure to consult your doctor!

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most important groups of medications for the treatment of diseases such as arthritis and osteoarthritis. The main function of these drugs is to reduce the level of inflammation in the joints, as well as reduce painful symptoms.

Unlike hormonal anti-inflammatory medications (corticosteroids), NSAIDs do not contain hormones and have much fewer side effects on the body as a whole.

What is important for a patient to know before using NSAIDs?

1. Despite their relative safety, most NSAIDs cannot be taken for long periods, since they have significant side effects and are contraindicated in many diseases of the gastrointestinal tract, liver, kidneys, and cardiovascular system.

2. Anti-inflammatory drugs should not be used if the patient currently or in the past has had diseases such as gastritis, gastric and duodenal ulcers, and colitis. Unfortunately, this group of drugs has an extremely negative effect on the mucous membranes, causing inflammation and even the formation of ulcers.

3. These medications should also be taken with great caution if you have kidney and liver diseases. NSAIDs have a strong effect on renal blood flow, causing water and sodium retention, which can provoke not only an increase in blood pressure, but also serious disruption of the renal apparatus, as well as the liver.

4. Sometimes some people may experience individual reactions of intolerance or hypersensitivity to anti-inflammatory drugs, so even in the absence of the diseases listed above, you should start taking them very carefully and in small doses, gradually.

5. Before taking the product, read all the instructions for it very carefully and act only in accordance with it.

6. In order to reduce the negative effect of NSAIDs on the gastric mucosa, take the tablets with as much liquid as possible - preferably a whole glass of water. When drinking, try to use only water, because other liquids may affect the absorption of the medicine.

7. Be careful not to take two or even three different NSAIDs at the same time. This is unlikely to increase the medicinal effect, but the number of side effects can easily multiply.

9. While taking medications from the NSAID group, it is recommended to refrain from drinking alcohol, since this greatly increases the negative effect on the gastric mucosa.

10. And finally, the most important advice: try not to self-medicate and take medications to treat joints, including these, only as prescribed by a doctor and under his supervision! This will allow you to avoid many complications when taking these medications and at the same time achieve maximum therapeutic effect.

List of NSAIDs for joint diseases

All NSAIDs are divided into 2 large groups: cyclooxygenase inhibitors of type 1 and type 2, abbreviated as COX-1 and COX-2.

Aspirin or acetylsalicylic acid

This is not only the very first drug discovered from this group of drugs, but also one of the oldest drugs in general: it continues to be used and prescribed, despite the fact that it has been around for more than a hundred years, and there are now many other synthesized and more effective drugs. Treatment of osteoarthritis often begins with aspirin.

Despite the fact that this remedy is effective in many areas of medicine, it is usually rather weak for the treatment of arthrosis and arthritis, and, as a rule, it is quickly replaced with other medications, or even treatment is started with other medications.

Aspirin should be taken with caution if you have blood disorders, as it slows down blood clotting.

Diclofenac

Perhaps one of the most popular NSAIDs, created back in the 60s. Available in both tablet and ointment form. This remedy for the treatment of arthrosis combines both high anti-pain activity and good anti-inflammatory properties.

It is produced under the names Voltaren, Naklofen, Ortofen, Diclak, Diclonac P, Vurdon, Olfen, Dolex, Dikloberl, Clodifen and others.

Read also the article about the “distant relative” of diclofenac - the drug Aceclofenac (Aertal).

Ibuprofen

This drug for the treatment of joints is slightly inferior in its anti-inflammatory and analgesic effect to other medications, including, for example, indomethacin, but is quite well tolerated.

This product is produced under the names Ibuprom, Advil, Reumafen, Nurofen, Faspik, MIG-400, Bonifen, Brufen, Ibalgin, Solpaflex, Burana, Dolgit, Bolinet, etc.

Indomethacin

In terms of its effect on inflammation, this is one of the most powerful; the analgesic effect of its use is also quite high.

Available in 25 mg tablets, gel, ointments, and rectal suppositories.

It has a fairly decent list of side effects, but is considered a highly effective drug for arthritis and arthrosis of the joints, and in addition, it is quite cheap (the cost of the tablet form, depending on the number of tablets, ranges from 15 to 50 rubles per pack).

This active substance can be supplied by various pharmaceutical companies under the names Metindol, Indovis EC, Indotard, Indocollir, Indovazin, etc.

Ketoprofen

In addition to the drugs listed above, the group of drugs of the first type, non-selective NSAIDs, i.e. COX-1, includes a drug such as ketoprofen. In terms of the strength of its action, it is close to ibuprofen, and is available in the form of tablets, gel, aerosol, cream, solutions for external use and for injection, rectal suppositories (suppositories).

You can buy this product under the trade names Artrum, Febrofid, Ketonal, OKI, Artrosilen, Fastum, Bystrum, Flamax, Flexen and others.

COX-2 inhibitors: new generation NSAIDs

This group of NSAIDs has a more selective effect on the body, due to which there are much fewer side effects on the gastrointestinal tract, and the tolerability of these drugs increases. In addition, it is generally accepted that some COX-1 drugs can negatively affect the condition of cartilage tissue. Medicines from the COX-2 group do not have this feature, and they are considered to be good drugs for arthrosis.

However, not everything is so rosy: many of the drugs in this group, without affecting the stomach, can negatively affect the cardiovascular system.

Drugs in this group include medications such as meloxicam, nimesulide, celecoxib, etoricoxib (Arcoxia) and others.

Meloxicam

One of the most well-known products with this active ingredient is movalis. The main advantage of this remedy is that, unlike diclofenac or indomethacin, it can be taken for a long time - many months and even years (of course, under regular medical supervision).

Meloxicam is available in the form of tablets, rectal suppositories, ointment and solution for intramuscular administration. Meloxicam (Movalis) tablets are good because they act for a long time, and it is enough to take just one tablet throughout the day - in the morning, or, for example, at night.

Other trade names of this active ingredient are Artrosan, Movasin, Mesipol, Amelotex, Melox, Meloflam, Mirlox, Bi-ksikam, Mixol-od, Lem, Melbek and Melbek-forte, Mataren, and, of course, the most famous in our country Movalis.

Buy Movalis in a pharmacy with home delivery or pickup

Celecoxib

The drug was originally developed by the pharmaceutical company Pfizer under the name Celebrex.

It has a fairly powerful anti-inflammatory and analgesic effect in arthritis and arthrosis, while giving virtually no side effects from the gastric mucosa and the gastrointestinal tract as a whole. The medicine comes in 100 and 200 mg capsules.

Nimesulide

In addition to the fact that nimesulide has sufficient anti-pain and anti-inflammatory effects for the treatment of joint arthrosis, it has antioxidant properties and slows down the action of substances that destroy cartilage tissue, collagen fibers and proteoglycans.

This medication has many different forms of release: gel for external use, tablets for oral administration and lozenges, granules for preparing a solution, etc.

Nimesulide is produced under the trade names Aulin, Rimesid, Nise, Mesulide, Nimegesik, Aktasulide, Nimika, Flolid, Aponin, Koxtral, Nimid, Prolide, etc.

Etoricoxib

Its form is best known in our country under the brand name Arcoxia. If the drug is taken in suitable, not very high dosages (up to 150 mg per day), then the effect on the gastric mucosa of this drug is very small - like other representatives of COX-2. For arthrosis of the joints, Arcoxia is usually prescribed at a dose of 30-60 mg per day.

You can buy the drug Arcoxia, for example, in this pharmacy

Since a medicine in this group can have a pronounced negative effect on the cardiovascular system, constant blood pressure checks should be carried out in the first days and weeks of taking this medicine.

And, of course, this drug should be taken only on the recommendation of a doctor and under his supervision.

Please note: even if you are using the newest and highest quality non-steroidal anti-inflammatory drugs, remember that these drugs DO NOT TREAT arthritis and arthrosis of the joints: they are only needed to reduce inflammation and relieve pain, after which physical therapy can be carried out and applied other treatment methods.

In order to stop the development of the disease and generally be treated correctly, you need to see a doctor and take comprehensive treatment, which includes taking medications from other groups, including chondroprotectors!

Cure arthrosis without drugs? It's possible!

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Many pathological changes occurring in the body accompany pain. NSAIDs, or drugs, have been developed to combat such symptoms. They provide excellent pain relief, relieve inflammation, and reduce swelling. However, the drugs have a large number of side effects. This limits their use in some patients. Modern pharmacology has developed the latest generation of NSAIDs. Such medications are much less likely to cause unpleasant reactions, but remain effective drugs against pain.

Impact principle

What causes the effect of NSAIDs on the body? They act on cyclooxygenase. COX has two isoforms. Each of them has its own functions. This enzyme (COX) causes a chemical reaction, as a result of which it turns into prostaglandins, thromboxanes and leukotrienes.

COX-1 is responsible for the production of prostaglandins. They protect the gastric mucosa from unpleasant effects, influence the functioning of platelets, and also affect changes in renal blood flow.

COX-2 is normally absent and is a specific inflammatory enzyme synthesized due to cytotoxins, as well as other mediators.

The action of NSAIDs, such as inhibition of COX-1, carries many side effects.

New developments

It is no secret that first-generation NSAID drugs had an adverse effect on the gastric mucosa. Therefore, scientists have set themselves the goal of reducing undesirable impacts. A new release form was developed. In such preparations, the active substance was in a special shell. The capsule was made from substances that did not dissolve in the acidic environment of the stomach. They began to break down only when they entered the intestines. This made it possible to reduce the irritant effect on the gastric mucosa. However, the unpleasant mechanism of damage to the walls of the digestive tract still remains.

This forced chemists to synthesize completely new substances. They differed fundamentally from previous drugs in their mechanism of action. New generation NSAIDs are characterized by a selective effect on COX-2, as well as inhibition of prostaglandin production. This allows you to achieve all the necessary effects - analgesic, antipyretic, anti-inflammatory. At the same time, NSAIDs of the latest generation make it possible to minimize the effect on blood clotting, platelet function, and gastric mucosa.

The anti-inflammatory effect is due to a decrease in the permeability of vascular walls, as well as a decrease in the production of various inflammatory mediators. Due to this effect, irritation of nerve pain receptors is minimized. The influence on certain thermoregulation centers located in the brain allows the latest generation of NSAIDs to effectively lower overall temperature.

Indications for use

The effects of NSAIDs are widely known. The effect of such drugs is aimed at preventing or reducing the inflammatory process. These medications provide an excellent antipyretic effect. Their effect on the body can be compared with the influence of In addition, they provide analgesic and anti-inflammatory effects. The use of NSAIDs is widespread in clinical settings and in everyday life. Today these are one of the popular medical drugs.

A positive effect is noted under the following factors:

1. Diseases of the musculoskeletal system. For various sprains, bruises, and arthrosis, these medications are simply irreplaceable. NSAIDs are used for osteochondrosis, inflammatory arthropathy, and arthritis. The medicine has an anti-inflammatory effect in myositis, herniated intervertebral discs.
2. Severe pain. The drugs are quite successfully used for biliary colic and gynecological ailments. They eliminate headaches, even migraines, and kidney discomfort. NSAIDs are successfully used for patients in the postoperative period.
3. Heat. The antipyretic effect allows the drugs to be used for a variety of ailments by both adults and children. Such medicines are effective even for fever.
4. Thrombosis. NSAID drugs are antiplatelet agents. This allows them to be used for ischemia. They are a preventative against heart attack and stroke.

Classification

About 25 years ago, only 8 groups of NSAIDs were developed. Today this number has increased to 15. However, even doctors cannot give an exact figure. Having appeared on the market, NSAIDs quickly gained widespread popularity. The drugs have replaced opioid analgesics. Since they, unlike the latter, did not provoke respiratory depression.

The classification of NSAIDs involves division into two groups:

1. Old drugs (first generation). This category includes well-known drugs: Citramon, Aspirin, Ibuprofen, Naproxen, Nurofen, Voltaren, Diklak, Diclofenac, Metindol, Movimed, Butadione .
2. New NSAIDs (second generation). Over the past 15-20 years, pharmacology has developed excellent drugs, such as Movalis, Nimesil, Nise, Celebrex, Arcoxia.

However, this is not the only classification of NSAIDs. New generation drugs are divided into non-acid derivatives and acids. Let's look at the last category first:

1. Salicylates. This group of NSAIDs contains the following drugs: Aspirin, Diflunisal, Lysine monoacetylsalicylate.
2. Pyrazolidines. Representatives of this category are the following drugs: “Phenylbutazone”, “Azapropazone”, “Oxyphenbutazone”.
3. Oxycams. These are the most innovative NSAIDs of the new generation. List of drugs: Piroxicam, Meloxicam, Lornoxicam, Tenoxicam. The drugs are not cheap, but their effect on the body lasts much longer than other NSAIDs.
4. Derivatives of phenylacetic acid. This group of NSAIDs contains the following drugs: Diclofenac, Tolmetin, Indomethacin, Etodolac, Sulindac, Aceclofenac.
5. Anthranilic acid preparations. The main representative is the drug Mefenaminat.
6. Propionic acid agents. This category contains many excellent NSAIDs. List of drugs: “Ibuprofen”, “Ketoprofen”, “Benoxaprofen”, “Fenbufen”, “Fenoprofen”, “Tiaprofenic acid”, “Naproxen”, “Flurbiprofen”, “Pirprofen”, “Nabumeton”.
7. Derivatives of isonicotinic acid. The main medicine is Amizon.
8. Pyrazolone preparations. The well-known remedy “Analgin” belongs to this category.

Non-acid derivatives include sulfonamides. This group includes the following drugs: Rofecoxib, Celecoxib, Nimesulide.

Side effects

New generation NSAIDs, the list of which is given above, have an effective effect on the body. However, they have virtually no effect on the functioning of the gastrointestinal tract. These drugs have one more positive aspect: new generation NSAIDs do not have a destructive effect on cartilage tissue.

However, even such effective means can provoke a number of undesirable effects. You should know them, especially if the drug is used for a long time.

The main side effects may be:

• dizziness;
• drowsiness;
• headache;
• fatigue;
• increased heart rate;
• increased blood pressure;
• slight shortness of breath;
• dry cough;
• indigestion;
• the appearance of protein in the urine;
• increased activity of liver enzymes;
• skin rash (spot);
• fluid retention;
• allergy.

However, damage to the gastric mucosa is not observed when taking new NSAIDs. The drugs do not cause exacerbation of the ulcer with bleeding.

The best anti-inflammatory properties are phenylacetic acid drugs, salicylates, pyrazolidones, oxicams, alkanones, propionic acid and sulfonamide drugs.

The medications that most effectively relieve joint pain are Indomethacin, Diclofenac, Ketoprofen, and Flurbiprofen. These are the best NSAIDs for osteochondrosis. The above medications, with the exception of Ketoprofen, have a pronounced anti-inflammatory effect. Piroxicam belongs to this category.

Effective analgesics are the drugs Ketorolac, Ketoprofen, Indomethacin, Diclofenac.

The leader among the latest generation of NSAIDs is the drug Movalis. This product can be used for a long period. Anti-inflammatory analogues of an effective drug are the drugs “Movasin”, “Mirlox”, “Lem”, “Artrosan”, “Melox”, “Melbek”, “Mesipol” and “Amelotex”.

The drug "Movalis"

This drug is available in the form of tablets, rectal suppositories and solution for intramuscular administration. The product belongs to enolic acid derivatives. The drug is distinguished by excellent analgesic and antipyretic properties. It has been established that this medicine brings a beneficial effect in almost any inflammatory process.

Indications for use of the drug are osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.

However, you should know that there are also contraindications to taking the drug:

• hypersensitivity to any of the components of the drug;
• peptic ulcer in the acute stage;
• severe renal failure;
• ulcerative bleeding;
• severe liver failure;
• pregnancy, breastfeeding;
• severe heart failure.

The drug should not be taken by children under 12 years of age.

For adult patients diagnosed with osteoarthritis, it is recommended to take 7.5 mg per day. If necessary, this dose can be increased by 2 times.

For rheumatoid arthritis and ankylosing spondylitis, the daily dose is 15 mg.

Patients prone to side effects should take the drug with extreme caution. People who have severe renal failure and are on hemodialysis should take no more than 7.5 mg per day.

The cost of the drug "Movalis" in tablets of 7.5 mg, No. 20, is 502 rubles.

Consumer opinion about the medicine

Reviews from many people who are subject to severe pain indicate that Movalis is the most suitable remedy for long-term use. It is well tolerated by patients. In addition, its long-term presence in the body makes it possible to take the medicine once. A very important factor, according to most consumers, is the protection of cartilage tissue, since the drug does not have a negative effect on them. This is very important for patients who use arthrosis.

In addition, the medicine perfectly relieves various pains - toothache, headache. Patients pay special attention to the impressive list of side effects. While taking NSAIDs, treatment, despite the manufacturer's warning, was not complicated by unpleasant consequences.

The drug "Celecoxib"

The action of this remedy is aimed at alleviating the patient’s condition with osteochondrosis and arthrosis. The drug perfectly eliminates pain and effectively relieves the inflammatory process. No adverse effects on the digestive system were identified.

Indications for use given in the instructions are:

• osteoarthritis;
• rheumatoid arthritis;
• ankylosing spondylitis.

This drug has a number of contraindications. In addition, the medicine is not intended for children under 18 years of age. Particular caution should be exercised by people diagnosed with heart failure, since the drug increases the susceptibility to fluid retention.

The cost of the drug varies, depending on the packaging, in the region of 500-800 rubles.

Consumer Opinion

Reviews about this medicine are quite contradictory. Some patients, thanks to this remedy, were able to overcome joint pain. Other patients claim that the drug did not help. Thus, this remedy is not always effective.

In addition, you should not take the drug yourself. In some European countries, this medicine is banned because it has cardiotoxic effects, which is quite harmful to the heart.

The drug "Nimesulide"

This medicine has not only anti-inflammatory and anti-pain effects. The product also has antioxidant properties, thanks to which the drug inhibits substances that destroy cartilage tissue and collagen fibers.

The product is used for:

• arthritis;
• arthrosis;
• osteoarthritis;
• myalgia;
• arthralgia;
• bursitis;
• fever;
• various pain syndromes.

At the same time, the medicine has an analgesic effect very quickly. As a rule, the patient feels relief within 20 minutes after taking the drug. That is why this remedy is very effective for acute paroxysmal pain.

Almost always, the medicine is well tolerated by patients. But sometimes side effects may occur, such as dizziness, drowsiness, headache, nausea, heartburn, hematuria, oliguria, urticaria.

The product is not approved for use by pregnant women and children under 12 years of age. People who have arterial hypertension, impaired functioning of the kidneys, eyesight or heart should take the drug "Nimesulide" with extreme caution.

The average price of the medicine is 76.9 rubles.

Before you start taking medications, consult your doctor. Taking medications without a doctor's advice can harm your body. Don't self-medicate

Nonsteroidal anti-inflammatory drugs (NSAIDs)- this is the optimal group of drugs that reduce the level of inflammation in the joints and reduce the degree of painful symptoms. Since NSAIDs do not contain hormonal components, unlike corticosteroids (hormonal anti-inflammatory drugs), the risk of side effects is much lower.

• Before you start using any medication, carefully read the instructions for it and act according to the recommendations. Simultaneous use of two or three types of NSAIDs is strictly not recommended. The risk of side effects increases, but the effectiveness of the drugs will not increase.
• The use of most NSAIDs affects the gastrointestinal tract, liver, kidneys and cardiovascular system. Long-term use of such drugs can negatively affect the functioning of these organs and lead to new diseases. In the presence of gastric and duodenal ulcers, gastritis, colitis, as well as in the case of previously cured these diseases, the use of anti-inflammatory drugs is unacceptable.

As a side effect of taking medications, inflammation of the mucous membrane of organs can occur, even leading to the occurrence of ulcers. If it is necessary to take NSAIDs for stomach diseases, the drugs are used in the form of rectal suppositories.

You should not use suppositories if you have hemorrhoids, fissures or polyps in the rectum.

• The medicine should be taken with plenty of water, at least 250 ml, while reducing the degree of irritation of the gastric mucosa. It is not recommended to drink other types of liquids; this affects the level of absorption of the drug.
• Since NSAIDs affect the retention of water and sodium in the kidneys, affecting the outflow of blood, taking anti-inflammatory drugs can not only cause hypertension, but also impair the functioning of the kidneys and liver. Therefore, if these organs are diseased, anti-inflammatory drugs are not recommended.
• Individual intolerance and hypersensitivity to drugs can cause negative consequences for the body. Regardless of the presence or absence of diseases of the internal organ system listed above, taking NSAIDs should be started gradually and with small doses and always under the supervision of the attending physician.
• The simultaneous use of anti-inflammatory drugs and alcohol is harmful to health, since the effect of the drug on the gastric mucosa increases several times. In addition, side effects may appear in the area of ​​disruption of the cardiovascular system.
• Pregnant women are not recommended to take NSAIDs. In case of urgent need for treatment with such drugs, be sure to consult your doctor.
• Taking NSAIDs, like any anti-inflammatory drugs, is carried out only after consultation with a doctor and under his supervision. Self-medication can cause complications and side effects, which can lead to negative consequences.

List of funds:

There are 2 types of NSAIDs: COX-1 and COX-2 inhibitors (cyclooxygenase types 1 and 2). The first type inhibitors include: aspirin, diclofenac, ibuprofen, indomethacin, ketoprofen.

Aspirin or acetylsalicylic acid

Acetylsalicylic acid (aspirin) is the most popular drug. Due to properties such as antipyretic, anti-inflammatory and analgesic effects, the medicine is prescribed for the treatment of rheumatoid arthritis.

The beginning of treatment for osteoporosis usually begins with aspirin, but with the advent of new and more effective drugs, this drug is losing in terms of effectiveness on the human body. Patients with a blood disorder should take aspirin with caution, as the drug slows down the blood clotting process.

Diclofenac - the drug was synthesized in 1966 in the Geigy laboratory and, due to its properties, showed excellent results in the treatment of rheumatoid joint diseases. The drug has an analgesic, anti-inflammatory effect, reduces swelling and swelling, and is well tolerated by the body.

Diclofenac is available in the form of tablets, ointments and injections. The most commonly used drugs are known as: Voltaren, Diclak, Diclonac P, Naklofen, Ortofen, Dolex, Vurdon, Olfen, Dikloberl, Clodifen and others.

Ibuprofen is most effective for inflammation of the joints, and its antipyretic effects are identical to aspirin. When used externally, in the form of applying ointment to the affected area, ibuprofen reduces hyperemia, relieves pain, and reduces the degree of swelling and morning stiffness. Good tolerance by the body was noted.

The drug is available in the form of suspensions, ointments and tablets, known under the names Ibuprom, Nurofen, Solpaflex, Faspik, Advil, Reumafen, MIG-400, Burana, Dolgit, Bonifen, Brufen, Ibalgin, Bolinet and others.

Indomethacin is one of the most effective non-hormonal agents. For arthritis, indomethacin relieves pain, reduces joint swelling and has a strong anti-inflammatory effect.

The price of the drug, regardless of the form of release (tablets, ointments, gels, rectal suppositories) is quite low, the maximum cost of tablets is 50 rubles per package. When using the drug you must be careful, as it has a considerable list of side effects.

In pharmacology, indomethacin is produced under the names Indovazin, Indovis EC, Metindol, Indotard, Indocollir.

Ketoprofen, or ketanol, is a widely used medicine in many areas of medicine in general and in the treatment of arthrosis in particular. Due to the high degree of analgesic and anti-inflammatory effects, the drug is often prescribed in the form of tablets, suspensions, ointments, suppositories, ointments, gels and aerosols, as well as injection solutions.

At the pharmacy you can buy ketoprofen under the names Artrosilen, Fastum, OKI, Flamax, Bystrum, Artrum, Febrofid, Ketonal, Flexen.

COX-2 inhibitors

Type 2 cyclooxygenase inhibitors (COX-2) include the following new generation NSAIDs: meloxicam, nimesulide, celecoxib, etoricoxib (Arcoxia) and others. Studies have shown that this group of NSAIDs has fewer side effects. At the same time, COX-2-selective agents have a selective effect on the body, without irritating the gastric mucosa with the correct dosage of oral medications.

Patients with diseases of the cardiovascular system are advised to take drugs from this group with caution, as complications in this area of ​​the body are possible. Measure your blood pressure regularly, and if it increases, contact your doctor.

Meloxicam is a drug whose main advantage is the possibility of long-term therapeutic use for months and even years without the occurrence of new side effects. Treatment must be carried out under medical supervision.

Movalis

Movalis is the most famous medicine based on meloxicam. In the treatment of arthritis and arthrosis, it is used as an anti-inflammatory agent and has analgesic properties. It is enough to take one tablet of Movalis at any time of the day, without reference to a regimen, treatment can be carried out throughout the year. Pharmacists produce meloxicam in the form of tablets, injections, ointments and rectal suppositories.

The following drugs are known, in which the main ingredient is meloxicam: Artrosan, Movasin, Mesipol, Melox, Mirlox, Bi-xicam, Melbek and Melbek-forte, Mataren, Mixol-od, Lem, Amelotex, Meloflam, and, most common in domestic pharmacies, Movalis.

Celecoxib

Celecoxib is available in the form of capsules of 100 and 200 ml. The main effect is an anti-inflammatory and analgesic that practically does not irritate the gastric mucosa. Known as Celebrex.

Nimesulide, like all drugs of the COX-2 group, is well tolerated by the body and has an analgesic and anti-inflammatory effect. A distinctive feature of nimesulide is the inhibition of the action of substances that destroy cartilage tissue and collagen fibers.

An indispensable drug in the treatment of arthrosis. The product is known under the following names: Aulin, Nimegesic, Aktasulide, Nimica, Flolid, Aponin, Koxtral, Nimid, Prolide, Rimesid, Nise, Mesulide - tablets, granules, gels.

Etoricoxib

Etoricoxib is marketed in pharmacology under the name Arcoxia. With small doses of this drug (up to 150 mg per day), it does not irritate the gastrointestinal mucosa. Effective in the treatment of joint diseases as an excellent analgesic with a high degree of anti-inflammatory effect.

You should start taking the medication with small doses and under the supervision of a doctor, since a side effect of taking etoricoxib is an increase in blood pressure. Daily monitoring of blood pressure is recommended. Technologies in medicine do not stand still and new generations and types of non-steroidal anti-inflammatory drugs aimed at treating arthritis and arthrosis are constantly appearing.

Despite the differences in the essence of these diseases (with arthritis, the joint becomes inflamed, swollen and painful; with arthrosis, the cartilage tissue does not have time to recover, and therefore painful symptoms appear when moving the joints), drugs for their treatment are selected from NSAIDs. In each specific case, an experienced doctor will prescribe a comprehensive treatment - tablets, injections and always externally - ointments and gels.

You should always remember the side effects of any medication, carefully read the instructions and follow the rules and regimen for taking medications.

The active ingredient of this medicine is celecoxib. This is a drug from the group of new generation NSAIDs, which has anti-inflammatory, antipyretic and analgesic activity.

Ulcerogenic activity (the risk of developing ulcers) is minimized - this is the advantage of Celebrex.

Indications for use of Celebrex – back pain, arthritis, spondylitis, algodismenorrhea (painful periods), familial adenomatous polyposis.

It is possible to use this drug as an independent remedy or in complex therapy.

The list of contraindications is quite long, in particular, Celebrex cannot be used during pregnancy, lactation, under 18 years of age, a number of diseases of the gastrointestinal tract, kidneys, liver and hematopoietic system.

Like many imported drugs (it is produced by Pfizer), Celebrex is quite expensive.

The price ranges from 400 to 600 rubles, in some pharmacies it may be higher, so there is a need to replace it with a cheap analogue. But finding cheap analogues of the drug can be difficult.

Russian-made analogues

There are no analogues of Celebrex from a completely domestic manufacturer. These drugs are almost entirely imported into our country from abroad.

The exception is the drug Dilaxa– it cannot be called Russian, but production is located in the Moscow region.

The medicine contains celecoxib. The drug is produced by the Slovenian company KRKA, one of whose factories is in the Moscow region.

Most of the Dilax drug on the domestic market is Russian-made under license from KRKA. In terms of its features, Dilaxa is close to Celebrex, but slightly lower in price. The cost is 200-250 rubles.

Koksib. Currently, the drug is in the process of registration, so there is no complete data about it.

The release date has not yet been specified, but it is known that it will be cheaper than Celebrex.

Ukrainian substitutes

There are Ukrainian-made analogues of Celebrex, which are produced under license from foreign companies (the same as Dilax). There are no analogues completely developed and produced in Ukraine.

Despite this, the Ukrainian drug market, containing celecoxib, is quite rich, and taking into account online pharmacies, the choice is even greater than on the domestic market.

Belarusian generics

Just like in Ukraine, Belarus does not have its own production of analogues of Celebrex. Some Belarusian enterprises are engaged in packaging and production of celecoxib drugs under a foreign license.

Mostly such drugs enter the Belarusian market under the international nonproprietary name - Celecoxib

Other foreign analogues

Generics are drugs that have the same composition as the original drugs, but are produced at other pharmaceutical plants and have a lower price.

The production of generic drugs is certified by the plant producing the original drug. The price is lower due to the fact that the generic manufacturer buys ready-made technology without investing in the development of the drug.

Close substitutes for Celebrex have the same active ingredient, fully retain their effectiveness, but cost 2-3 times less.

Their prices can be even lower if you order from online pharmacies with delivery. The main producing countries of such generics are India and Egypt.

Such drugs include:

• Zitsel.
• Atroxib.

Drug Zitsel, India. The active ingredient is celecoxib. It has the same indications, contraindications and side effects as the original product.

Sold without a prescription, the price is about 200 rubles. Prescribed for joint diseases, back pain, painful menstruation, and for the treatment of colorectal polyps.

Arthroxib, India. Another inexpensive analogue of Celebrex. Included in the list of the most popular and effective medicines for joints.

The active ingredient is celecoxib, indications are diseases of the joints and spine, painful periods. In cost it can compete with Zitsel; these drugs can be considered equivalent.

In addition to drugs that contain the same active substance (synonymous drugs), medications are used that contain active principles that are similar in their properties - NSAIDs of the coxib group.

Among them:

1. Denebol.
2. Bextra.
3. Arcoxia.
4. Distanat.

Bextra. The active ingredient is valdecoxib. Indications are similar to Celebrex - diseases of the joints, spine, acute pain syndrome, algodismenorrhea.

Not the best choice if the question arises of how to replace Celebrex - the drugs are comparable in price. It has a fairly long list of contraindications and side effects.

Arcoxia (Netherlands, Spain). Contains etoricoxib. It is considered a safer drug than Celebrex, because. has fewer side effects.

Approved for use in pregnant women, if the benefit to the mother outweighs the potential risk to the fetus. In terms of price, it is far from the cheapest medicine; depending on the pharmacy, it can be more expensive than Celebrex.

Below is a table listing modern drugs from the coxib group that can be considered analogues of Celebrex.

Their names, countries of origin, and average prices for them are indicated:

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