Viferon rectal suppositories 150000 IU In what cases are candles shown? Rectal suppositories Viferon and their use for the treatment of children

Do you want to strengthen the immune system, prevent infection and viruses? Try Viferon. The drug of domestic production is recommended by doctors for the treatment and prevention of colds, flu, to enhance the body's natural defenses, in the complex therapy of various diseases. Learn more about the drug.

Viferon candles - instructions

The drug is widely used not only at home, but also in hospitals, maternity hospitals, children's hospitals. Candles are the most popular form, because they are more effective than gel, ointment. The tool is a special complex consisting of human interferon alpha, ascorbic acid, alpha-tocopherol acetate. If the doctor prescribed Viferon suppositories, the instructions should be studied without fail.

The drug helps the body produce its own interferons, protects against the effects of various pathogens and their reproduction to a critical state. It is effective for herpes, influenza, viral hepatitis and other diseases caused by fungal flora, protozoa, atypical microorganisms. Candles are prescribed for adults, newborns, premature babies, children of different ages.

Viferon ointment

Often a local remedy is recommended for use in the presence of foci of inflammation on the skin of the face, lips. If Viferon ointment is prescribed, the instructions for use should be read before starting treatment. According to clinical studies, the drug effectively eliminates herpes skin rashes in 5-7 days, if applied correctly. According to the annotation, the ointment should be applied to the lesions up to 3-4 times a day immediately after the first signs appear (itching, redness).

Viferon gel

In this form of medicine, the composition of active substances is the same as in candles. The difference is only in the way of influence. Use Viferon gel - the instructions for using the product are simple, it is convenient to apply the medicine. The gel is recommended for use in lesions of the mucous membranes: with herpes infection, cervicitis, stenosing laryngotracheobronchitis. The medicine is safe, allowed during pregnancy. Viferon's instruction states that the active substances act only on the lesions, without being absorbed into the blood.

For kids

Various diseases that occur in babies require safe, immediate treatment. In the pharmacy you can always find a children's drug that will help alleviate the child's condition and avoid complications. After the agent enters, viruses begin to die, inflammatory processes decrease, and damaged tissues heal. Viferon for children can be used for stomatitis, purulent-septic conditions, SARS, influenza, chickenpox. Candles are more commonly used. For children under 12 years old, a drug with doses of 500 thousand and 1 million IU is suitable.

For babies

The drug is always prescribed as part of complex therapy, since it has a small therapeutic effect. Viferon for newborns is used in the minimum dosage and with a short course of therapy. It is prescribed for:

It is more convenient for infants to administer suppositories, other forms of the drug are either contraindicated or more difficult to use. The maximum effect is achieved if used after a stool. How to put candles Viferon? Recommendations for parents:

wash the child, dry it, lay it on the barrel in a safe place without panties;
quickly get a candle, open it so that it does not have time to melt in your hands;
push the buttocks to the baby and gently, without haste, introduce the suppository;
turn the baby on the tummy, wait 15 minutes for the drug to dissolve.

For adults

The tool can be used by people of different ages. The form of the tool is not important. Ointment and gel should be applied in a thin layer to the affected area, but candles should be used according to the instructions. Viferon is recommended for adults at a dosage of 3 million IU. Indications for use:

urogenital infections;
prevention of influenza, SARS;
herpes;
shingles;
laryngotracheitis of a viral and bacterial nature;
angina;
herpetic stomatitis;
rashes on the mucous membrane of the mouth.

The tool is actively used in gynecology. As part of the therapeutic complex, doctors prescribe it to women with candidiasis, chlamydia, bacterial vaginosis, papillomavirus infection. The dosage of Viferon depends on the existing disease. In all these cases, additional use of vaginal suppositories is required. Also, the tool can be used by women:

during pregnancy (candles - from 29 weeks);
when breastfeeding;
during menstruation.

Contraindications

It is noted that the drug of any form of release is well tolerated by patients of different ages. Patients with allergies should be careful - possible hypersensitivity to the components of the drug. Even if the doctor prescribes Viferon, contraindications should be taken into account independently. You should not use the medicine if you have:

chronic diseases of the cardiovascular system;
renal failure;
decompensated form of diabetes mellitus;
thyroid diseases.

Viferon - side effects

During the course of treatment in some categories of patients, consequences are possible. If you choose the drug Viferon - be sure to study the side effects. Very rarely, people experience an allergic reaction, manifested by itching, skin rashes. If you stop taking, the symptoms disappear in 3 days. The drug is dispensed without a prescription, so when using the product on your own, you need to be as careful as possible.

Price

When compared with other antibacterial, immunostimulating, antiviral drugs, the medicine is relatively inexpensive. It can be bought in online stores, conventional pharmacies, ordered through catalogs of official representatives at a reduced price. How much does Viferon cost? The price depends on the form of release and dosage.

In the season of colds, interferon-based preparations are real helpers. They successfully fight viruses. They have anti-inflammatory properties. Contribute to recovery in every possible way. Candles "Viferon 150000" (instruction for the drug is attached and fully describes all the features of the use of the drug) are intended for children, as they have a minimum dosage of 150,000 IU of interferon. They are used in the treatment of influenza, SARS and many other diseases. The medication is affordable and easy to use. Should only be used as directed by a physician.

Composition and form of release

The instruction of the candle "Viferon 150000" refers to antiviral drugs. Notes that the drug belongs to the group of cytokines. Contains human interferon alpha-2b in the amount of 150,000 IU. Additional components in the composition of the drug are:

vitamin C;
sodium ascorbate;
alpha-tocopherol acetate;
disodium edetate dihydrate;
polysorbate-80;
cocoa butter;
confectionery fat.

The medicine is produced in the form of rectal suppositories, which have a yellowish tint. Candles may have a heterogeneous consistency with visible inclusions. Their diameter is 10 mm.

The medicine is produced in PVC blisters. The package may contain 1-2 blisters and instructions for use. Each blister contains five or ten candles.

Instruction candles for children "Viferon" (dosage 150,000) advises to store at a temperature of 2-8 degrees. In a place protected from the sun and out of the reach of children. The shelf life of the drug is two years. It is not recommended to use the medication after the expiration date.

Produced "Viferon" in Russia, the company LLC "Feron".

Pharmacological properties of the drug

Candles "Viferon 150000" (the instruction describes in detail the effect of the drug on the human body) have antiviral, antiproliferative and immunomodulatory qualities. They inhibit the replication of cells containing RNA and DNA viruses. Due to the immunomodulatory property of the drug, the phagocytic activity of macrophages increases, the cytotoxicity of lymphocytes towards target cells increases, which characterizes its mediocre antibacterial functions.

Ascorbic acid together with alpha-tocopherol acetate enhance the antiviral properties of the drug. Increase the immunomodulatory activity of interferon alpha-2b. As a result, it enhances the response of the body's immune system when exposed to pathogenic bacteria.

The drug increases the rate of secretory immunoglobulins, which belong to class A. Stabilizes immunoglobulin E. Restores the work of the endogenous apparatus of alpha-2b interferon. Vitamins A and E are considered active antioxidants. They are characterized by membrane-stabilizing, regenerating and anti-inflammatory actions.

Instructions for use candles "Viferon 150000" calls safe. Notes that they do not provoke the appearance of side effects. Do not create antibodies that neutralize the antiviral activity of interferon alfa-2b.

Suppositories are often used in complex therapy, which makes it possible to reduce the dosage of other medicines used in treatment. It can be antibacterial and hormonal medicines. In addition, "Viferon" allows you to reduce the toxicity of the drugs used.

Cocoa butter is rich in polyunsaturated fatty acids, which contribute to easier administration and dissolution of the drug in the intestine. It also contains phospholipids that replace toxic emulsifiers that are harmful to the body and are often used in the manufacture of drugs.

In what cases are candles shown?

The instruction "Viferon 150000" (candles) recommends using it for viral respiratory diseases. This applies to influenza and pneumonia of various genesis. This drug, due to the low dosage of the active substance, is indicated for use in children.

Suppositories are also prescribed for newborn babies who suffer from diseases of an infectious and inflammatory nature. The purpose for use is sepsis and infections obtained during intrauterine development. First of all, it is herpes, enterovirus infection, chlamydia, cytomegalovirus infection, candidiasis of various origins. In all of the above cases, "Viferon" is used in complex treatment.

Recommend medication for use in children diagnosed with viral hepatitis B, C and D. In this case, the drug can be used together with plasmapheresis and hemosorption. It is used to treat viral hepatitis in the chronic stage of development and accompanied by cirrhosis of the hepatic organ.
For adults, the drug is prescribed for ailments associated with the urogenital tract. These are the diagnoses:

chlamydia;
trichomoniasis;
cytomegalovirus infection;
bacterial vaginosis;
ureaplasmosis;
vaginal candidiasis;
gardnerellosis;
mycoplasmosis;
papillomavirus infection.

Candles for children "Viferon" (150,000 IU) instruction advises to use for herpetic lesions of the mucous membranes and skin. When the infection has a localized form, as well as in severe, moderate and mild illness. The drug is prescribed for urogenital herpes in adults.

Contraindications and side effects

Candles "Viferon 150000" have practically no contraindications. An exception is the individual intolerance of the components contained in the composition of the drug.

The drug can be used during breastfeeding. During pregnancy, candles are recommended to be used starting from the 14th week.

Cases of overdose with "Viferon" were not registered.

Suppositories rarely provoke adverse reactions. In isolated cases, an allergy occurs, which disappears after discontinuation of the drug, within 72 hours.

Candles "Viferon 150000": instructions for children

The drug is intended for rectal administration. One suppository contains 150,000 IU of human alpha-2b interferon.
In acute respiratory diseases, the dosage for children over 7 years of age and adults is 500,000 IU. This amount is calculated for one administration. The drug is used twice a day, morning and evening. The break between the introduction of candles should be 12 hours. The duration of therapy is five days. If necessary, treatment with this medication can be extended.

Children under seven years of age and newborn infants, including premature babies, whose gestational age is 34 weeks or more, the drug is administered one suppository twice a day. The dose for one injection should not exceed 150,000 IU. Between the introduction of suppositories, a break equal to twelve hours should be observed. The duration of treatment is five days. If necessary, after a five-day break, therapy can be continued.

For newborn infants with diseases of an infectious and inflammatory nature, the drug is prescribed twice a day, one suppository with a dosage of 150,000 IU. Treatment should take place every day. The interval between the administration of the drug is 12 hours. The course of therapy is five days.

Premature babies whose gestational age is 34 weeks or older are given 150,000 IU three times a day for five days.

The number of therapeutic courses may vary depending on the diagnosis, so with:

sepsis, two or three cycles of treatment are recommended;
meningitis, two courses of five days are shown;
herpes of various origins, two therapeutic approaches are prescribed;
enterovirus infection, doctors advise to take one or two treatment courses;
CMV infections, two or three cycles of treatment are prescribed;
candidiasis or mycoplasmosis, up to three therapeutic courses are required.

The drug in the diagnosis of hepatitis B, C and D is used in the complex treatment of children and adults. In viral hepatitis, accompanied by complications that have become chronic, the treatment of adults is carried out with a dosage of 3,000,000 IU. You need to enter candles twice a day, every twelve hours. The course of therapy lasts ten days. Then the suppositories are administered three times a week, every 24 hours for 6 or 12 months. The duration of treatment is prescribed by the doctor, based on the picture of the disease.

Children from seven years of age are advised to use a daily dose determined at the rate of 5,000,000 IU divided by the square meter of the entire surface area of the child's body.

The drug in the treatment of children is administered for ten days in a row, twice a day, every twelve hours. Duration is determined by the course of the disease.
Candles "Viferon 150000" should not be taken on their own, without a doctor's prescription. After all, only a doctor, assessing the course of the disease, can correctly prescribe the duration of treatment and correctly calculate the dose.

Compatibility with other drugs

Candles "Viferon 150000" for children can be combined with all medicines that are used in the treatment of diseases indicated in the indications. Often these are antibiotics, glucocorticosteroids and chemotherapy drugs.

Analogues

Usually well tolerated by patients and does not cause negative symptoms of children's "Viferon 150000" (candles). Instructions for use describe in detail the contraindications and side effects that may occur as a result of drug treatment. But, if, for some reason, this medication is not suitable for therapy, the following analogues will help to replace it:

"Infagel", the price is 100-130 rubles.
"Genferon", from 350 rubles.
"Genferon light", from 200 rubles.
"Laferon", from 100 rubles.
"Laferobion", from 270 rubles.
"Anaferon", 200-300 rubles.
"Kipferon", from 500 rubles.
"Grippferon", from 250 rubles.

The pharmacy chain offers many more antiviral drugs containing human interferon, but only a doctor should decide how to replace Viferon 150000 candles for children. In order to avoid a negative reaction of the body, you should not replace the medication yourself.

The cost of the drug

Instructions for use of the candle "Viferon" (150,000 IU) recommends using the dose recommended by the doctor and not using the drug for more than five days continuously. The drug is often used in pediatrics, as it is very effective and has an acceptable cost.

So, the price of 10 suppositories of 150,000 IU is 250 rubles, candles with a dosage of 500,000 IU cost about 350 rubles, and a medication with a dosage of 1,000,000 IU can be purchased for 540 rubles. The drug is widely distributed and is sold in every pharmacy. Released without a doctor's prescription.

Release form: Solid dosage forms. Suppositories are rectal.

General characteristics. Compound:

Active ingredient: 150,000 IU, 500,000 IU, 1,000,000 IU or 3,000,000 IU human recombinant interferon alfa-2b.

Excipients: alpha-tocopherol acetate, ascorbic acid, sodium ascorbate, disodium edetate dihydrate, polysorbate-80, cocoa butter base and confectionery fat.

Pharmacological properties:

Pharmacodynamics. Interferon alpha-2b human recombinant has immunomodulatory, antiviral, antiproliferative properties. Immunomodulatory properties of interferon, such as increased phagocytic activity of macrophages, increased specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon increases, its immunomodulating effect increases, which makes it possible to increase the efficiency of the body's own immune response to pathogenic microorganisms. When using the drug, the level of class A secretory immunoglobulins increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been established that when using Viferon, there are no side effects that occur with parenteral administration of interferon preparations, no antibodies are formed that neutralize the antiviral activity of interferon.

The use of the drug allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as to reduce the toxic effects of this therapy.

Cocoa butter contains phospholipids, which make it possible not to use synthetic toxic emulsifiers in production, and the presence of polyunsaturated fatty acids facilitates the administration and dissolution of the drug.

Indications for use:

- acute respiratory viral infections, including those complicated by a bacterial infection (bacterial, viral, chlamydial) in children and adults as part of complex therapy;
- infectious and inflammatory diseases of newborns, including premature babies: (bacterial, viral), (chlamydia, herpes, candidiasis, including visceral, mycoplasmosis) as part of complex therapy;
- chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use and in chronic viral hepatitis of severe activity, complicated by cirrhosis of the liver;
- infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults as part of complex therapy;
- primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults.

Important! Get to know the treatment

Dosage and administration:

The drug is used rectally. 1 suppository contains human recombinant interferon alfa-2b as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU).

Acute respiratory viral infections, including influenza, including those complicated by a bacterial infection, pneumonia (bacterial, viral, chlamydial) in children and adults as part of complex therapy.Recommended dose for adults, including pregnant women and children over 7 years of age VIFERON® 500,000 IU 1 suppository 2 times a day every 12 hours daily for 5 days. According to clinical indications, therapy can be continued.

Children under 7 years of age, including newborns and premature babies with a gestational age of more than 34 weeks, are recommended to use the drugVIFERON® 150,000 IU 1 suppository 2 times a day every 12 hours daily for 5 days. According to clinical indications, therapy can be continued. The break between courses is 5 days.

For premature newborns with a gestational age of less than 34 weeks, the use of VIFERON® 150,000 IU is recommended.1 suppository 3 times a day after 8 hours daily for 5 days.According to clinical indications, therapy can be continued. The break between courses is 5 days.

Infectious and inflammatory diseases of newborns, including premature infants: meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) as part of complex therapy.The recommended dose for newborns, including premature babies with a gestational age of more than 34 weeks, is VIFERON® 150,000 IU daily, 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.

Premature newborns with a gestational age of less than 34 weeks are recommended to use the drug VIFERON® 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.

The recommended number of courses for various infectious and inflammatory diseases: sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection - 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis, candidiasis, including visceral — 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

Chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of severe activity, complicated by liver cirrhosis.The recommended dose for adults is VIFERON® 3,000,000 IU, 1 suppository 2 times a day every 12 hours daily for 10 days, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

Children aged 1 to 7 years are recommended 3,000,000 IU per 1 m2 of body surface area per day.

The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

The calculation of the daily dose of the drug for each patient is made by multiplying the recommended dose for a given age by the body surface area calculated from the nomogram to calculate the body surface area by height and weight according to Harford, Terry and Rourke. The calculation of a single dose is carried out by dividing the calculated daily dose by 2 injections, the resulting value is rounded up to the suppository dosage up.

In chronic viral hepatitis of severe activity and cirrhosis of the liver, before plasmapheresis and / or hemosorption, it is recommended to use VIFERON® 150,000 IU for children under 7 years of age, VIFERON® 500,000 IU for children over 7 years of age, 1 suppository 2 times a day every 12 hours within 14 days.

Infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women as part of complex therapy.The recommended dose for adults is VIFERON® 500,000 IU, 1 suppository 2 times a day every 12 hours daily for 5-10 days. According to clinical indications, therapy can be continued.

2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150,000 IU1 suppository 2 times a day after 12 hours daily for 5 days.

If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults, including pregnant women.The recommended dose for adults is VIFERON® 1,000,000 IU, 1 suppository 2 times a day every 12 hours every day for 10 days or more in case of recurrent infection. According to clinical indications, therapy can be continued. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear.

In the treatment of recurrent herpes, it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

Pregnant women from the II trimester of pregnancy (starting from the 14th week of gestation) are recommended to use the drug VIFERON® 500,000 IU, 1 suppository2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150000 IU 1 suppository 2 times a day after 12 hours daily for 5 days. If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Dosing regimen	Week of gestation*	Application scheme
From the 14th week of gestation VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days. Then VIFERON® 500,000 IU 1 suppository 2 times a day after 3 days, 3 times for 9 days.
Step 1. C + C (morning/evening) VIFERON® 500,000 IU



Step 2 C + C (morning/evening) VIFERON® 150,000 IU	20, 24 28, 32 36, 40
From 38 weeks of gestation to delivery VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days.
C + C (morning/evening) VIFERON® 500,000 IU

Application Features:

Influence on the ability to drive vehicles and engage in other activities. Not installed.

Use during pregnancy and during breastfeeding: The drug is approved for use from the 14th week of pregnancy. Has no restrictions for use during breastfeeding.

Side effects:

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Interaction with other drugs:

VIFERON®, rectal suppositories, is compatible and well combined with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy drugs, glucocorticosteroids).

Contraindications:

Hypersensitivity to any of the components of the drug.

Overdose:

Not installed.

Storage conditions:

At a temperature of 2 to 8 ° C, in a place protected from light. Keep out of the reach of children. Shelf life - 2 years. Do not use the drug after the expiration date.

Leave conditions:

Without recipe

Package:

Rectal suppositories 150000 IU, 500000 IU, 1000000 IU, 3000000 IU. 5 or 10 suppositories in PVC/PVC blisters. 1 blister pack of 10 suppositories or 2 blister packs of 5 suppositories with instructions for use in a cardboard pack.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon increases, its immunomodulating effect increases, which makes it possible to increase the efficiency of the body's own immune response to pathogenic microorganisms. When using the drug, the level of class A secretory immunoglobulins increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been found that when using viferon there are no side effects that occur with parenteral administration of interferon preparations, no antibodies are formed that neutralize the antiviral activity of interferon. The use of the drug allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as to reduce the toxic effects of this therapy.

Indications for use

in the complex therapy of various infectious and inflammatory diseases in children, including newborns and premature infants: acute respiratory viral infections, including influenza, including those complicated by a bacterial infection, pneumonia (bacterial, viral, chlamydial), meningitis (bacterial, viral), sepsis , intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis);
in the complex therapy of chronic viral hepatitis B, C, D in children and adults, including in combination with the use of plasmapheresis and hemosorption, in chronic viral hepatitis of severe activity, including those complicated by liver cirrhosis;
in complex therapy in adults, including pregnant women, with urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, human papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including urogenital form;
in the complex therapy of acute respiratory viral infections, including influenza, including those complicated by a bacterial infection in adults.

Contraindications

hypersensitivity to any of the components of the drug.

Use during pregnancy and lactation

the drug is approved for use from the 14th week of pregnancy. It has no restrictions for use during lactation.

Dosage and administration

the drug is used rectally. 1 suppository contains human recombinant interferon alfa-2b as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU).

In the complex therapy of various infectious and inflammatory diseases in newborns, including premature babies: newborns, including premature babies with a gestational age of more than 34 weeks, are prescribed VIFERON® 150000 IU daily, 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.

Premature newborns with a gestational age of less than 34 weeks are prescribed VIFERON® 150000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.
The recommended number of courses for various infectious and inflammatory diseases in children, including newborns and premature babies: SARS, including influenza, including those complicated by a bacterial infection - 1-2 courses; pneumonia (bacterial, viral, chlamydial) - 1-2 courses, sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis , candidiasis, including visceral, - 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

In the complex therapy of chronic viral hepatitis B, C, D in children and adults: for children with chronic viral hepatitis, the drug is prescribed in the following age doses: up to 6 months 300,000-500,000 IU per day; from 6 to 12 months - 500,000 IU per day. At the age of 1 to 7 years - 3,000,000 IU per 1 m2 of body surface area per day. At the age of over 7 years - 5,000,000 IU per 1 m2 of body surface area per day. The calculation of the dose of the drug for each specific patient is carried out by multiplying the dose recommended for a given age by the body surface area calculated from the nomogram to calculate the body surface area by height and weight according to Harford, Terry and Rourke, divided by 2 injections, rounded up to the dosage of the corresponding suppository. The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

Children with chronic viral hepatitis of severe activity and cirrhosis of the liver before plasmapheresis and / or hemosorption are shown to use the drug for 14 days daily, 1 suppository 2 times a day after 12 hours (children under 7 years old VIFERON® 150,000 IU, children over 7 years old - VIFERON® 500000 IU).

Adults with chronic viral hepatitis are prescribed VIFERON® 3000000 IU 1 suppository 2 times a day after 12 hours for 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

In complex therapy in adults, including pregnant women, with urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), with primary or recurrent herpetic infection of the skin and mucous membranes ( localized form, mild to moderate course, including urogenital form).

Adults, with the above infections, except for herpetic, are prescribed VIFERON® 500000 IU 1 suppository 2 times a day after 12 hours. The course is 5-10 days. According to clinical indications, therapy can be continued with intervals between courses of 5 days.

For herpetic infection, VIFERON® 1000000 IU 1 suppository 2 times a day after 12 hours. The course of treatment is 10 days or more with recurrent infection. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear. In the treatment of recurrent herpes, it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

In pregnant women with urogenital infection, including herpetic, in the II trimester of pregnancy (starting from week 14) - VIFERON® 500,000 IU 1 suppository every 12 hours (2 times a day) for 10 days, then 1 suppository every 12 hours (2 times a day) twice a week - 10 days. Then, after 4 weeks, prophylactic courses of the drug VIFERON® 150,000 IU are carried out, 1 suppository every 12 hours - for 5 days, the prophylactic course is repeated every 4 weeks. If necessary, it is possible to conduct a treatment course before childbirth.

In the complex therapy of acute respiratory viral infections, including influenza, including those complicated by a bacterial infection in adults. Apply VIFERON® 500000 IU 1 suppository 2 times a day every 12 hours daily. The course of treatment is 5-10 days.

Side effect

in rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.
Interaction with other drugs: VIFERON®, rectal suppositories, compatible and well combined with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy, glucocorticosteroids).

Release form

rectal suppositories 150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU. 10 suppositories in a blister PVC / PVC type Rotoplast. 1 cell package with instructions for use in a cardboard box.
Shelf life: 2 years. Do not use the drug after the expiration date.
Storage conditions: at a temperature of 2 to 8 ° C, in a place protected from light.
Keep out of the reach of children.

main parameters

Name:	VIFERON
ATX code:	L03AB05 -

1 suppository VIFERON® 150000 ME contains the active substance: interferon alpha-2b human recombinant 150000 ME, excipients:

alpha-tocopherol acetate 0.055 g, ascorbic acid 0.0054 g, sodium ascorbate 0.0108 g, disodium edetate dihydrate 0.0001 g, polysorbate-80 0.0001 g, cocoa butter base 0.1958 g and confectionery fat 0.7828 G.

1 suppository VIFERON® 500000 ME contains the active substance: interferon alfa-2b human recombinant 500000 ME, excipients:

1 suppository VIFERON® 1000000 ME contains the active substance: interferon alpha-2b human recombinant 1000000 ME, excipients:

alpha-tocopherol acetate 0.055 g, ascorbic acid 0.0081 g, sodium ascorbate 0.0162 g, disodium edetate dihydrate 0.0001 g, polysorbate-80 0.0001 g, cocoa butter base 0.1941 g and confectionery fat 0.7764 G.

1 suppository VIFERON® 3000000 ME contains the active substance: interferon alpha-2b human recombinant 3000000 ME, excipients:

Alpha-tocopherol acetate 0.055 g, ascorbic acid 0.0081 g, sodium ascorbate 0.0162 g, disodium edetate dihydrate 0.0001 g, polysorbate-80 0.0001 g, cocoa butter base 0.1941 g and confectionery fat 0.7764 g.

Description

Bullet-shaped suppository, white with a yellowish tint, homogeneous consistency. Color heterogeneity in the form of marbling is allowed. On the longitudinal section there is a funnel-shaped depression. The diameter of the suppository is not more than 10 mm.

pharmachologic effect

Interferon alpha-2b human recombinant has immunomodulatory, antiviral, antiproliferative properties. Immunomodulatory properties of interferon, such as increased phagocytic activity of macrophages, increased specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity. In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon increases, its immunomodulating effect increases, which makes it possible to increase the efficiency of the body's own immune response to pathogenic microorganisms. When using the drug, the level of class A secretory immunoglobulins increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. The use of the drug allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as to reduce the toxic effects of this therapy.

Pharmacokinetics

When administered rectally, the bioavailability of interferon alfa-2b is about 80%. The maximum concentration of interferon in the blood serum is reached 3-8 hours after the administration of the drug. Interferon alfa-2b is eliminated by renal catabolism. Tsh is 12 hours, which necessitates its re-introduction.

Indications for use

■ in the complex therapy of various infectious and inflammatory diseases in children, including newborns and premature infants: acute respiratory viral infections, including influenza, including those complicated by a bacterial infection, pneumonia (bacterial, viral, chlamydial), meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis);

■ in complex therapy in adults, including pregnant women, with urogenital infection (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including urogenital form;

■ in the complex therapy of acute respiratory viral infections, including influenza, including those complicated by a bacterial infection in adults.

Contraindications

Pregnancy and lactation

Hypersensitivity to any of the components of the drug.

Dosage and administration

The drug is used rectally. 1 suppository contains human recombinant interferon alfa-2b as an active substance in the indicated dosages (150,000 ME, 500,000 ME, 1,000,000 ME, 3,000,000 ME).

In the complex therapy of various infectious and inflammatory diseases in newborns, including premature babies: newborns, including premature babies with a gestational age of more than 34 weeks, are prescribed VIFERON® 150,000 ME daily, 1 suppository 2 times a day after 12 hours. Course of treatment - 5 days.

Premature newborns with a gestational age of less than 34 weeks are prescribed VIFERON® 150,000 ME daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.

The recommended number of courses for various infectious and inflammatory diseases in children, including newborns and premature babies: SARS, including influenza, including those complicated by a bacterial infection - 1-2 courses; pneumonia (bacterial, viral, chlamydial) - 1-2 courses, sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis , candidiasis, including visceral, - 2-3 courses. The break between courses is 5 days.

According to clinical indications, therapy can be continued

For adults, with the above infections, except for herpetic, appoint VIFERON® 500000 ME 1 suppository 2 times a day after 12 hours. The course is 5-10 days. According to clinical indications, therapy can be continued with intervals between courses of 5 days.

In case of herpetic infection, VIFERON® 1000000 ME is prescribed, 1 suppository 2 times a day after 12 hours. The course of treatment is 10 days or more in case of recurrent infection. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear. In the treatment of recurrent herpes, it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

In pregnant women with urogenital infection, including herpes, in the II trimester of pregnancy (starting from week 14) - VIFERON® 500000 ME 1 suppository every 12 hours (2 times a day) for 10 days, then 1 suppository every 12 hours (2 times a day) twice a week - 10 days. Then, after 4 weeks, prophylactic courses of VIFERON® 150,000 ME are carried out, 1 suppository every 12 hours - for 5 days, the prophylactic course is repeated every 4 weeks. If necessary, it is possible to conduct a treatment course before childbirth.

In the complex therapy of acute respiratory viral infections, including influenza, including those complicated by a bacterial infection in adults. Apply VIFERON® 500000 ME 1 suppository 2 times a day every 12 hours every day. The course of treatment is 5-10 days.

Side effect

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Overdose

Cases of overdose with the use of the drug are not registered.