Veroshpiron tablets from what and their use. Veroshpiron from what helps how to take

INN: spironolactone. Contains 25 mg for tablets, 50 or 100 mg for capsules.

Additional substances in tablets: talc, silicon dioxide, lactose monohydrate, magnesium stearate, corn starch.

Additional substances in capsules: sodium lauryl sulfate, lactose monohydrate, magnesium stearate, corn starch.

pharmachologic effect

Competitive aldosterone antagonist , potassium-sparing diuretic.

Pharmacodynamics and pharmacokinetics

The main substance spironaloctone . In the distal parts of the nephron, it prevents the retention of water and sodium by aldosterone, reduces the potassium excretion effect of aldosterone, reduces permease synthesis . Maximum effect from taking the drug is noted 7 hours after taking the capsule, last for 24 hours. decline blood pressure achieved by a diuretic effect, it manifests itself after 2-5 weeks of administration. The active substance becomes active metabolites. The drug is excreted by the kidneys.

Indications for use Veroshpiron

What is the cure for? Consider why Veroshpiron is prescribed.

Tablets and capsules are used in the composition combination therapy at essential hypertension . Indications for the use of Veroshpiron are also: edematous syndrome in CHF, nephrotic syndrome, ascites, cirrhosis of the liver. The drug is also used as excipient in prevention hypomagnesemia/hypokalemia during treatment with diuretics. The drug has been successfully used in Kohn's syndrome during the preoperative short course of treatment, as well as in order to establish a diagnosis " Primary hyperaldosteronism ».

Contraindications

Contraindications for Veroshpiron are: hypersensitivity to the components medicinal product, hyperkalemia, hyponatremia, Addison's disease , heavy kidney failure(CC less than 10 ml / min), and the period of breastfeeding. With extreme caution, the drug is prescribed for metabolic, hypercalcemia, AV blockade, diabetes, diabetic nephropathy, violations menstrual cycle, general and local anesthesia, with diseases of the liver, kidneys, as well as in the elderly.

Side effects

Gastrointestinal tract: diarrhea, nausea, vomiting, , intestinal colic, violation of the liver.

Central nervous system : lethargy, ataxia, headaches, dizziness, lethargy, drowsiness, muscle spasm, confusion, convulsions of the calf muscles.

Side effects from hematopoietic organs: thrombocytopenia, megaloblastosis.

Metabolism: hypercreatininemia, hyperuricemia, hyperkalemia, increased urea levels, hyponatremia, hyperchloremic metabolic alkalosis and acidosis.

Endocrine system: men may develop gynecomastia, reduced potency. In women, dimenorrhea, terorrhagia, and breast carcinoma are possible.

Allergic reaction: pruritus, drug fever, urticaria, erythematous, maculo-papular rash.

Dermatological reaction: hypertrichosis, .

urinary system: acute renal failure.

Application instruction of Veroshpiron (Method and dosage)

For capsules and tablets of Veroshpiron, the instructions for use are the same. It all depends on the amount active substance.

Essential hypertension: Adults: 50-100 mg once. The dose can be gradually increased to 200 mg, the amount of the drug is increased 1 time in 2 weeks.

Idiopathic hyperaldosteronism: 100-400 mg per day.

Severe hyperaldosteronism, hypokalemia: per day 300 mg for 2-3 doses. Gradually, the dose of the drug is reduced to 25 mg per day.

Hypomagnesemia, nipokalemia, provoked by the action of diuretics: 25-100 mg per day, once or in several doses.

Diagnosis and treatment of primary hyperaldosteronism: 400 mg per day for 4 days. The daily dose of the drug is divided into several doses.

How to take with swelling?

Edema in nephrotic syndrome: adults 100-200 mg per day. Veroshpiron is used only if other methods of treatment have been ineffective.

Edema syndrome in CHF: 100-200 mg per day (several doses) for 5 days in combination with thiazide and "loop" diuretics. The daily dose can be reduced to 25 mg.

Edema in cirrhosis: if the Na + / K + ratio in the urine is above 1.0, then 100 mg is prescribed. If less than 1.0 then daily dose- 200-400 mg.

Edema in children: initially 1-3.3 mg per 1 kg of body weight, or 30-90 mg / m2 per day for 1-4 doses. Dose adjustments are made after 5 days.

How long can you take?

The usual course is 20 days, followed by a break of at least six months. The longest can be used for a couple of months. With prolonged use, you can get acute renal failure.

How to take before meals or after?

Overdose

Terms of sale

Requires a prescription.

Storage conditions

In a place inaccessible to children at temperatures up to 30 degrees Celsius.

Best before date

Not more than 5 years.

special instructions

Veroshpiron in gynecology is prescribed to reduce the rate in women with PCOS (). The drug can cause bleeding, disrupt the menstrual cycle. Veroshpiron is often recommended to be taken in conjunction with the aim of normalizing the menstrual cycle, reducing hirsutism.

Recipe in Latin:

Rp.: Verospironi 0.025
D.t. d. No. 20 in tabl.
S.

Wikipedia does not have an article about the drug.

During pregnancy

The drug is contraindicated in pregnancy and breastfeeding.

Veroshpiron's analogs

Matches by ATX code 4th level:

Analogues of the drug are:,. The price of analogues is lower.

Reviews about Veroshpiron

Reviews about Veroshpiron on the forums testify in favor of this drug. The medicine is effective, but it is advised to use it in moderation and as prescribed by the doctor, since the remedy has side effects and contraindications.

Diuretic tablets fully cope with the function assigned to them, and also effectively help with edema. In gynecology, the drug has been successfully used for SCJ.

Veroshpiron also helps for weight loss, as it has a diuretic property.

Those who have used the medication claim that it does not help with hirsutism.

Veroshpiron price, where to buy

The price of Veroshpiron in tablets is 75 rubles for 20 pieces.

Capsules can be bought for 160 rubles for 30 pieces of 50 mg and for 250 rubles for 30 pieces of 100 mg.

How much does the drug cost in Ukraine? The price of Veroshpiron in Kharkiv averages 100 UAH for 20 tablets of 25 mg.

• Internet pharmacies in Russia Russia
• Internet pharmacies in Ukraine Ukraine
• Internet pharmacies in Kazakhstan Kazakhstan

WER.RU

Veroshpiron capsules 50 mg 30 pcs.

Veroshpiron tablets 25 mg 20 pcs.Gedeon Richter [Gedeon Richter]

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The state of health of many patients requires the appointment of diuretics. The family of these drugs is quite numerous, but very often doctors still prefer veroshpiron. What do these pills help with, what is their plus, how is this medicine taken and why can't it be drunk for weight loss?

Veroshpiron and its difference from other diuretics

Diuretics are distinguished by one unpleasant quality: when they are taken together with excess fluid potassium is also lost. Veroshpiron is devoid of such a disadvantage. This is a high-quality and effective potassium-sparing diuretic, the basic component of which is spironolactin.

The mechanism of action of the drug is quite complex. It is enough for patients to know that its active substance acts on the adrenal cortex, blocking the formation of the hormone aldosterone (namely, it promotes the removal of potassium during water retention). As a result, the liquid, along with sodium and chlorine, leaves the body, and potassium reserves are not depleted.

The use of Veroshpiron tablets helps to eliminate edema, lower blood pressure, and improve blood circulation. It is produced in capsules (the proportion of the active substance in them is 50 or 100 mg) and tablets (25 mg). The diuretic effect when taking the drug is observed after 2-5 days. Spironolactin is completely absorbed in the gastrointestinal tract (it is also able to pass through the placenta and enter breast milk) and leaves the body with urine (60%) and feces (40%).

What will this medicine help with?

Veroshpiron is usually prescribed by endocrinologists. Here's what these pills are prescribed for:

• edema caused by heart failure;
• violations at work endocrine organs(multiple ovarian cysts, hirsutism, Conn's disease);
• arterial hypertension;
• ascites (with cirrhosis of the liver);
• swelling of the brain;
• paroxysmal myoplegia, provoked by a lack of calcium;
• myasthenia gravis;
• nephrotic syndrome;
• massive burns;
• swelling during pregnancy.

Since self-administration of the drug is not allowed, the doctor selects the scheme for taking it. The patient should not reduce or increase the dose himself. Standard daily dosages prescribed by the instructions for the use of Veroshpiron tablets for different pathologies, are:

• cirrhosis - from 100 to 400 mg;
• nephrotic syndrome - 100-200 mg;
• edema - 100-200 mg;
• hypertension - from 50 to 100 mg 1-4 r. per day for 14 days;
• polycystic ovaries and high content male hormones in the body of a woman - 100 mg 2 r. per day;
• children from 3 years old - from 30 to 90 mg once or in 4 divided doses.

The medicine is taken 3-4 r. per day daily during or immediately after meals for 5 days, and the dose is either gradually reduced and adjusted to 25 mg, or increased to 400 mg. Then drink 1 table. 4 p. per day at intervals of 3 days.

Possible side effects

Despite the proven effectiveness and ability of Veroshpiron not to deplete potassium reserves, it can cause quite a lot adverse reactions. Here are some negative manifestations sometimes accompanied by taking this drug:

• loose stools or constipation;
• pressure drop;
• dehydration;
• hyperkalemia;
• violation of the heart rhythm;
• inflammation of the stomach;
• intestinal colic;
• ulcerative lesions of the digestive tract and internal bleeding;
• nausea;
• stomach ache;
• vomit;
• dizziness;
• lethargy, drowsiness;
• changes in the composition of the blood (thrombocytopenia, a decrease in the level of leukocytes, an increase in the concentration of creatinine);
• headache;
• muscle cramps;
• disorder of coordination of movements;
• increased levels of uric acid;
• megaloblastosis (proliferation of bone marrow cells);
• a painful condition that is characterized by immobility, lack of response to external stimuli(lethargy).

At long-term use drug in men may develop gynecomastia (an increase in breast tissue), a decrease in potency. And in women - menstrual disorders and complete absence menstruation, pathology of the mammary glands, coarsening of the voice, hair growth male type, allergic manifestations.

Caution: when is it better to refrain from taking the drug?

Even if there are indications for taking Veroshpiron, but the patient has an excess of potassium, sodium deficiency, impaired kidney function, allergies, then its use should be abandoned. This diuretic is not prescribed during breastfeeding (if this is not possible, then the baby will have to be transferred to IV). The question of the advisability of its use by a pregnant woman is decided by the doctor.

Contraindications also include:

• diabetes;
• adrenal insufficiency;
• Addison's disease;
• reduction or complete cessation of urination;
• first trimester of pregnancy;
• liver failure;
• violation acid-base balance in the body (metabolic acidosis).

Particular care should be taken when prescribing Veroshpiron to the elderly, women with dysmenorrhea, as well as local anesthesia and general anesthesia.

Analogues

These are drugs belonging to the same pharmaceutical group, which contain different active substances(INN), differ from each other in name, but are used to treat the same diseases.

• - Pills

Indications for use of the drug Veroshpiron

Essential hypertension (as part of combination therapy);

Edema syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);

Conditions in which it may be detected secondary hyperaldosteronism, including cirrhosis of the liver, accompanied by ascites and / or edema, nephrotic syndrome, as well as other conditions accompanied by edema;

Hypokalemia/hypomagnesemia (as aid for its prevention during treatment with diuretics and when it is impossible to use other methods of correcting the level of potassium);

Primary hyperaldosteronism (Kohn's syndrome) - for a short preoperative course of treatment;

To establish the diagnosis of primary hyperaldosteronism.

Release form of the drug Veroshpiron

Tablets 25 mg; blister 20, cardboard pack 1;

Tablets 25 mg; bag (bag) polyethylene 6 kg, box (box) polypropylene 1;

Tablets 25 mg; bag (bag) polyethylene 12 kg, box (box) polypropylene 1;

Tablets 25 mg; blister 20, box (box) 1;

Tablets 25 mg; plastic bag (bag) 6 kg;

Tablets 25 mg; plastic bag (bag) 12 kg;

Pharmacokinetics of the drug Veroshpiron

When taken orally, it is rapidly and completely absorbed from the gastrointestinal tract, binding to plasma proteins is about 98%. Turns into active metabolites: a metabolite containing sulfur (80%) and partially into canrenone (20%). Cmax of canrenone in blood plasma is achieved after 2-4 hours, its binding to plasma proteins is 90%.

After daily intake 100 mg of spironolactone for 15 days Cmax reaches 80 ng / ml, the time to reach Cmax after the next morning dose is 2-6 hours.

Spironolactone does not penetrate well into organs and tissues, while itself and its metabolites penetrate the placental barrier, and canrenone - into breast milk. The volume of distribution is 0.05 l / kg. T1 / 2 spironolactone 13-24 hours, active metabolites - up to 15 hours.

Excreted by the kidneys: 50% - in the form of metabolites, 10% - unchanged and partially - with stool. Excretion of canrenone (mainly by the kidneys) is biphasic, T1 / 2 in the first phase - 2-3 hours, in the second - 12-96 hours.

With cirrhosis of the liver and heart failure, the half-life period increases without signs of cumulation, the likelihood of which is higher in chronic renal failure and hyperkalemia.

Use of the drug Veroshpiron during pregnancy

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications to the use of the drug Veroshpiron

Hypersensitivity to any of the components of the drug;

Addison's disease;

Hyperkalemia, hyponatremia;

Severe renal failure (Cl creatinine<10 мл/мин), анурия;

Pregnancy;

breastfeeding period.

Carefully:

hypercalcemia;

metabolic acidosis;

AV blockade (hyperkalemia contributes to its strengthening);

Diabetes mellitus (with confirmed or suspected chronic renal failure);

diabetic nephropathy;

Surgical interventions, local and general anesthesia;

Taking drugs that cause gynecomastia;

Elderly age;

Violation of the menstrual cycle, enlargement of the mammary glands;

Liver failure;

Cirrhosis of the liver.

Side effects of the drug Veroshpiron

From the gastrointestinal tract: nausea, vomiting, diarrhea, ulceration and bleeding from the gastrointestinal tract, gastritis, intestinal colic, abdominal pain, constipation.

On the part of the liver: impaired liver function.

From the side of the central nervous system: ataxia, lethargy, dizziness, headache, drowsiness, lethargy, confusion, muscle spasm.

From the hematopoietic system: agranulocytosis, thrombocytopenia, megaloblastosis.

On the part of laboratory parameters: hyperuricemia, hypercreatininemia, increased urea concentration, impaired water-salt metabolism (hyperkalemia, hyponatremia) and acid-base balance (metabolic hyperchloremic acidosis or alkalosis).

On the part of the endocrine system: coarsening of the voice, in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible, only in rare cases the mammary gland remains slightly enlarged); decreased potency and erection; in women - menstrual irregularities; dysmenorrhea; amenorrhea; metrorrhagia in menopause; hirsutism; pain in the mammary glands; breast carcinoma (the presence of a connection with taking the drug has not been established).

Allergic reactions: urticaria, rarely - maculopapular and erythematous rash, drug fever, itching.

On the part of the skin: alopecia, hypertrichosis.

From the urinary system: acute renal failure.

From the musculoskeletal system: spasms of the calf muscles.

Dosage and administration of Veroshpiron

In essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, while the dose should be increased gradually, 1 time in 2 weeks.

To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.

With idiopathic hyperaldosteronism - 100-400 mg / day.

With severe hyperaldosteronism and hypokalemia - 300 mg / day (maximum 400 mg) for 2-3 doses, with improvement in the condition, the dose is gradually reduced to 25 mg / day.

Hypokalemia / hypomagnesemia - with hypokalemia and / or hypomagnesemia caused by diuretic therapy - at a dose of 25-100 mg / day, once or in several doses. The maximum daily dose is 400 mg if oral potassium preparations or other methods of replenishing its deficiency are ineffective.

Diagnosis and treatment of primary hyperaldosteronism

As a diagnostic tool for a short diagnostic test - 400 mg / day, divided into several doses per day, for 4 days. With an increase in the concentration of potassium in the blood while taking the drug and a decrease after its withdrawal, one can assume the presence of primary hyperaldosteronism.

With a long-term diagnostic test - at the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.

Short course of preoperative therapy for primary hyperaldosteronism - after the diagnosis of hyperaldosteronism is established using more accurate diagnostic methods, Veroshpiron should be taken at 100-400 mg / day, divided into 1-4 doses per day during the entire period of preparation for surgery. If the operation is not indicated, then Veroshpiron is used for long-term maintenance therapy, while using the smallest effective dose, which is selected individually for each patient.

Edema on the background of nephrotic syndrome - the daily dose for adults is usually 100-200 mg / day. No effect of spironolactone on the underlying pathological process has been identified, and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.

With edematous syndrome against the background of chronic heart failure - 100-200 mg / day in 2-3 doses daily for 5 days, in combination with a "loop" or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum dose is 200 mg / day.

Edema on the background of cirrhosis of the liver - if the ratio of sodium and potassium ions (Na + / K +) in the urine exceeds 1, then the daily dose for adults is usually 100 mg. If the ratio is less than 1, then the daily dose for adults is usually 200–400 mg. The maintenance dose is selected individually.

Edema in children - the initial dose is 1-3.3 mg / kg or 30-90 mg / m2 / day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Overdose with Veroshpiron

Symptoms: nausea, vomiting, dizziness, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry mouth, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.

Treatment: gastric lavage, symptomatic treatment of dehydration and arterial hypotension. In case of hyperkalemia, it is necessary to normalize the water-electrolyte metabolism with the help of potassium-releasing diuretics, rapid parenteral administration of a dextrose solution (5-20% solution) with insulin at the rate of 0.25-0.5 IU per 1 g of dextrose; can be re-entered if necessary. In severe cases, hemodialysis is performed.

Interactions of the drug Veroshpiron with other drugs

Reduces the effect of anticoagulants (heparin, coumarin derivatives, indandione) and the toxicity of cardiac glycosides (because the normalization of the level of potassium in the blood prevents the development of toxicity).

Enhances the metabolism of phenazole (antipyrine).

Reduces the sensitivity of vessels to norepinephrine (requires caution when conducting anesthesia), increases the half-life of digoxin - digoxin intoxication is possible.

Enhances the toxic effect of lithium due to a decrease in its clearance.

Accelerates the metabolism and excretion of carbenoxolone.

Carbenoxolone promotes sodium retention by spironolactone.

GCS and diuretics (benzothiazine derivatives, furosemide, ethacrynic acid) enhance and accelerate the diuretic and natriuretic effects.

Enhances the action of diuretic and antihypertensive drugs.

NSAIDs reduce the diuretic and natriuretic effect, increasing the risk of developing hyperkalemia.

GCS enhance the diuretic and natriuretic effect in hypoalbuminemia and / or hyponatremia.

The risk of developing hyperkalemia increases when taken with potassium supplements, potassium supplements and potassium-sparing diuretics, angiotensin-converting enzyme inhibitors (acidosis), angiotensin II receptor antagonists, indomethacin, cyclosporine.

Salicylates, indomethacin reduce the diuretic effect.

Ammonium chloride, cholestyramine contribute to the development of hyperkalemic metabolic acidosis.

Fludrocortisone causes a paradoxical increase in tubular potassium secretion.

Reduces the effect of mitotane.

Enhances the effect of triptorelin, buserelin, gonadorelin.

Special instructions when taking the drug Veroshpiron

A temporary increase in the level of urea nitrogen in the blood serum is possible, especially with reduced kidney function and hyperkalemia. Reversible hyperchloremic metabolic acidosis is possible.

In diseases of the kidneys and liver, as well as in old age, regular monitoring of blood serum electrolytes and kidney function is necessary.

The drug makes it difficult to determine digoxin, cortisol and adrenaline in the blood. Despite the absence of a direct effect on carbohydrate metabolism, the presence of diabetes mellitus, especially with diabetic nephropathy, requires special care due to the possibility of hyperkalemia.

In the treatment of NSAIDs, kidney function and blood electrolyte levels should be monitored. Potassium-rich foods should be avoided. During treatment, alcohol is contraindicated.

In the initial period of treatment, it is forbidden to drive a car and engage in activities that require increased concentration of attention and speed of psychomotor reactions. The duration of the restrictions is set individually.

Storage conditions of the drug Veroshpiron

List B.: At a temperature of 15–30 °C.

Shelf life of the drug Veroshpiron

Belonging of the drug Veroshpiron to ATX-classification:

C Cardiovascular system

C03 Diuretics

C03D Potassium-sparing diuretics

C03DA Aldosterone antagonists

Instruction

Pathologies associated with the kidneys and urinary canal are accompanied by a violation of the outflow of urine and the accumulation of salts in it. To increase the process of diuresis, doctors prescribe specialized drugs from the category of diuretics. One of these is Veroshpiron 25.

Composition and action

The drug is considered a diuretic. The main component is spironolactone. One tablet contains 25 mg. There are additional ingredients in the form:

• magnesium stearate;
• silicon dioxide;
• talc;
• corn starch;
• lactose monohydrate.

It is often prescribed for renal pathologies, because it has a diuretic and diuretic effect. Increases urination, fights edema.

Release form

The drug is sold in tablets with a dose of 25 mg. They differ in a whitish tint, rounded and flat shape. On one side there is a chamfer with the name of the drug. There is a characteristic odor.
The total number of tablets - 20 pcs.

Pharmacological properties of the drug Veroshpiron 25

The active component in the form of spirolactone belongs to the category of potassium-sparing diuretics and competitive aldosterone antagonists (acts as a hormone that is formed by the adrenal cortex). Shows a prolonged and hypotensive effect.

Pharmacodynamics

In the distal region of the nephron, it helps to prevent the retention of water and sodium with the help of aldesterone. The potassium excretion effect decreases, the synthesis of permease decreases. There is a decrease in the acidity of urine.
The hypotensive effect is provided due to the diuretic action. Normalization of diuresis occurs 2-5 days after the start of therapeutic measures.

Pharmacokinetics

After use, the main component instantly and completely enters the bloodstream from the intestinal canal. The maximum concentration occurs after 2-6 hours. 98% binds to plasma proteins. It is metabolized in the liver to active sulfur-containing substances in the form of 7-alpha-thiomethylspironolactone and canrenone. Excreted simultaneously with urine and feces after 12-24 hours.

Indications for use

Tablets are prescribed for various pathological processes, which are accompanied by severe edema. This symptom most often indicates the retention of water and sodium ions in the body and a decrease in potassium ions.
This process occurs in some diseases in the form of:

• essential hypertension;
• idiopathic hyperaldosteronemia;
• congestive heart failure;
• liver cirrhosis as part of complex treatment;
• hypokalemia.

The drug can be used to achieve a long-lasting diuretic effect to maintain the level of potassium ions in the body.

With kidney pathologies

After taking the tablets, potassium is excreted in the urine. At the same time, the secretion of sodium into the tubules of the kidneys increases, excess fluid is removed from the tissue structures. The acidity of urine returns to normal against the background of an increase in the concentration of urea.
The main effect of the drug is to remove excess fluid. Due to this, the volume of circulating blood in the kidneys and the overall vascular resistance decrease.

nephrotic syndrome

The medication is prescribed as an additional technique in the absence of positive dynamics from the treatment of the underlying disease. Nephrotic syndrome is accompanied by severe swelling of tissues and organs. This process acts as a complication of other pathologies. To remove excess fluid and normalize the process of urination, preparations based on spironolactone are used. A positive result occurs in 5-7 days.

Application of the drug Veroshpiron 25

The selection of the dose depends on the age of the patient and the type of pathological process.
With the development of edema due to chronic heart failure, liver cirrhosis or nephrotic syndrome, the drug is prescribed 100 mg in the first days. Multiplicity of use - three times a day. Then the treatment is corrected. With a positive result, there is a decrease to 25 mg or an increase to 200 mg.
The drug is advised to use in patients with hypokalemia, if they do not have the effect of oral administration of potassium preparations. The daily dosage is 25-100 mg.

How many days to take Veroshpiron 25

The treatment course lasts an average of 3 weeks. After that, a break is made for 3-6 months. In severe cases, the course is extended to 2 months. With prolonged treatment, acute renal failure may occur.

Contraindications

Not all patients can use the medicine. There are several restrictions in the form:

• severe cardiovascular diseases;
• strong susceptibility to spironolactone;
• hyperkalemia;
• hyponatremia;
• severe renal failure;
• lack of lactose;
• syndrome of malabsorption of glucose and galactose.

Tablets are prescribed with caution to patients with hypercalcemia, acidosis, diabetes mellitus, diabetic nephropathy. The drug can be used after surgical procedures or medications that cause gynecomastia.

Side effects

During the treatment course, side symptoms may appear in the form of:

• nausea, urge to vomit, diarrhea;
• exacerbation of gastritis or periodic pain in the abdomen;
• agranulocytosis, thrombocytopenia;
• pain in the head, dizziness, drowsiness;
• menstrual disorders, pain in the mammary glands;
• skin rashes, itching and redness.

In severe cases, Quincke's edema or anaphylactic shock develops. Women develop amenorrhea or gynecomastia. Adversely affects the nervous system in the form of lethargy, confusion, spasm and ataxia.

Overdose

With an overdose, there is an increase in side symptoms. This process is accompanied by:

• nausea and vomiting;
• dizziness and low blood pressure;
• diarrhea and abdominal pain;
• dehydration and an increase in the concentration of urea.

Treatment consists in gastric lavage and symptomatic therapy. If hyperkalemia occurs, it is necessary to normalize the water balance with the help of potassium-excreting diuretics. In severe situations, hemodialysis is performed.

special instructions

During the use of the drug, the level of nitrogen in the blood may temporarily increase. This process is especially visible with a decrease in the functionality of the kidneys.
If the patient has impaired kidney and liver function, then it is necessary to regularly monitor the level of electrolytes in the blood.
During therapeutic measures, it is difficult to determine the concentration of digoxin, cortisol and adrenaline.
In the early days, you can not drive a vehicle or work with mechanisms, because the active substance affects the concentration of attention and reaction speed.

Can I take during pregnancy and lactation

The drug is not allowed to be used by expectant and nursing mothers.

Application in childhood

It is forbidden to give medicine to a newborn, infant and a child under 3 years of age. Dosage in children depends on body weight. The initial dose is calculated according to the following formula: 1-3.3 mg per 1 kg of weight. The daily dose is divided into 2-4 doses. After 5 days, the treatment is adjusted depending on the result.

For impaired renal function

Tablets are not taken if the patient has severe renal failure. With caution, the drug is used for diabetic nephropathy.

For impaired liver function

drug interaction

Spironolactone reduces the effect of anticoagulants and the toxicity of cardiac glycosides.
With simultaneous use with Phenazol, an increase in the metabolic process is observed.
The susceptibility of vessels to Norepinephrine decreases, therefore, it is necessary to resort with caution to anesthesia.
Glucocorticosteroids and drugs based on benzothiazine, furosemide and ethacrynic acid enhance and accelerate the diuretic and natriuretric effects.
There is an increase in efficiency when the drug is combined with Triptorelin, Buserelin, Gonadorelin.

Analogues

If the tablets are not on sale, then they can be replaced by means similar in composition and effect, including:

1. Spironolactone.
2. Renial.
3. Epitor.

If a decision is made to replace the product, then it is worth reading the annotation.

Terms and conditions of storage

Terms of dispensing from pharmacies

The drug cannot be bought without a doctor's prescription.

Price

The cost depends on the amount of spironolactone. An average of 20 pcs. can be purchased for 70-96 rubles. The price may differ depending on the region.

Veroshpiron

Veroshpiron is a medication belonging to the group of potassium-sparing diuretics. I will consider the instructions for using this drug in more detail.

Composition and dosage form Veroshpiron

The drug is produced in round white tablets, they are flat, there is a chamfer, on one side there is a marking in the form of "VEROSPIRON". The drug has a characteristic odor. The active ingredient is spironolactone at a dosage of 25 milligrams.

Auxiliary components: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, corn starch, and also added talc.

Tablets, in the amount of 20 pieces, are placed in special blisters, which are packed in cardboard packs. You need to store them out of the reach of children at a temperature of no more than 30 degrees. The shelf life of the drug is five years. It can only be bought with a prescription.

Another dosage form of Veroshpiron is represented by gelatin hard capsules of size No. 3, their cap is opaque, it is colored yellow, and the body is white. The active substance is spironolactone at a dosage of 50 mg. Auxiliary compounds: sodium lauryl sulfate, lactose monohydrate, magnesium stearate, in addition there is corn starch.

The composition of the gelatin capsule itself: quinoline yellow, gelatin, titanium dioxide. The drug is placed in blisters of ten pieces, the date of manufacture of the medication is affixed to the package.

Another dosage form is represented by capsules of size No. 0, with an orange cap and a yellow opaque body. The active substance is spironolactone in the amount of 100 mg. The medication is dispensed upon presentation of a prescription.

Pharmacological action of Veroshpiron

Potassium-sparing diuretic Veroshpiron is a competitive aldosterone antagonist. Spironolactone prevents sodium and water retention, in addition suppresses the potassium excretion effect, reduces the synthesis of so-called permeases in the distal tubules.

The hypotensive effect of the drug is due to the diuretic effect, which begins to appear already on the second or fifth day of therapy. After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability is almost 100%. Protein binding - 98%.

Treatment with Veroshpiron

Indications for use Veroshpiron

Among the indications for the use of Veroshpiron, the following conditions can be noted:

The presence of essential hypertension;
With primary hyperaldosteronism;
With edematous syndrome that has developed against the background of heart failure;
The drug is prescribed in conditions where secondary hyperaldosteronism can be detected, including liver cirrhosis, nephrotic syndrome and other conditions that are accompanied by edema.

In addition, Veroshpiron is indicated for use in hypokalemia and hypomagnesemia.

Contraindications to the use of Veroshpiron

I will list contraindications when a potassium-sparing diuretic is not used:

In the presence of Addison's disease;
With hyperkalemia and hyponatremia;
With hypersensitivity to the components of the drug;
A contraindication is the presence of anuria;
With renal failure;
During pregnancy;
The drug is contraindicated in lactose intolerance, in addition to lactase deficiency, as well as in the presence of glucose or galactose malabsorption syndrome;
Up to the age of three;
When breastfeeding.

Veroshpiron is used with caution in metabolic acidosis, in the presence of AV blockade, in diabetes mellitus, in surgical interventions, in diabetic nephropathy, in addition to anesthesia, both local and general, as well as menstrual irregularities and in old age.

Reception of Veroshpiron and dosage

With essential hypertension, the dose of Veroshpiron can vary from 50 to 100 mg, it is taken once a day, while the amount of the drug can increase to 200 mg. To achieve the optimal response of the body to ongoing therapy, the medication should be taken for at least two weeks.

With idiopathic hyperaldosteronism, the dosage of the drug can range from 100 to 400 mg / day. With edematous syndrome against the background of cirrhosis of the liver, the dose is usually 100 mg.

Overdose of the drug Veroshpiron

In case of an overdose, there will be the following symptoms: hyponatremia, nausea, vomiting, hypercalcemia, dizziness, decreased pressure, rash, diarrhea, dehydration develops, in addition, the concentration of urea increases.

In this case, the patient should urgently wash the stomach, after which the doctor performs symptomatic treatment of hypotension and dehydration, in severe situations, hemodialysis is indicated.

Side effects Veroshpiron

Usually, side effects are manifested by nausea, vomiting, colic, diarrhea, there may be constipation, ulceration in the gastrointestinal tract, abnormal liver function, gastritis, ataxia, lethargy, headache, lethargy, dizziness, confusion, drowsiness.

Laboratory changes: agranulocytosis, thrombocytopenia, hyperuricemia, megaloblastosis, hypercreatininemia, hyponatremia, increased urea, hyperkalemia, metabolic acidosis or alkalosis.

Other manifestations: alopecia, decreased erection, hypertrichosis, hirsutism, coarsening of the voice, muscle spasm, gynecomastia, cramps in the calf muscles develop, amenorrhea, erythematous rash, drug fever, soreness of the mammary glands, and a rash may develop.

Veroshpiron's analogs

Spironolactone, Aldactone, Urakton, Spirix, Spironaxan, Verospilactone, Spironol.

Conclusion

The use of Veroshpiron should be carried out after the prescription of the drug by a qualified doctor.