Water-based chlorhexidine instructions for use. Instructions for use of chlorhexidine bigluconate solution

The search for a pill to cure all diseases has not yet yielded results. But the World Health Organization has created a list of essential drugs. They also included chlorhexidine. This is a powerful antiseptic to combat microorganisms on the surface of the skin and some mucous membranes.

What is chlorhexidine used for?

What is chlorhexidine used for: amazing things are nearby!

Everyone is already accustomed to resorting to medications about which little is known. Often such medications are underestimated.

Doctors can best answer what chlorhexidine is used for.
This antibacterial agent is available in the form of solutions, suppositories, and gels.
Without it, it is impossible to imagine undergoing an operation, preventing sexually transmitted diseases, or disinfecting.
Any skin damage can be disinfected with this product - an abrasion, a wound (if it is not an open head injury or an eye disease), a scratch, a bite.

To do this, you can use a chlorhexidine solution or gel.

For treating the mucous surface of the oral cavity.
Stomatitis and gingivitis caused by pathogenic microorganisms will go away much faster.
Treatment of damaged skin areas after cosmetic procedures such as ear piercing, navel piercing (healing of the umbilical wound of newborns), as well as tattooing.

Chlorhexidine will help prevent possible sexually transmitted infections (not viruses!), such as syphilis, gonorrhea

For disinfecting common objects, washing hands in nature, before surgery. Disinfection – in the operating room, patient’s room.

Important! An interesting feature of the product is its “indifference” to soap procedures. Soap does not completely wash away the substance, so it continues to protect the “user” from dangerous microorganisms for some time. The only undesirable combination is the use of this antiseptic with iodine. Their “enmity” can result in dermatitis and burns for a person.

The instructions will tell you how to use chlorhexidine

Despite the wide range of its (almost limitless) influence, the antiseptic has contraindications and has not been sufficiently studied for use by pregnant women and children.
But the manufacturers claim that it is not contraindicated at any period of interest.
The decision is made by the doctor.

It is better to check with the specialist who prescribed it how to use chlorhexidine.

To combat possible sexually transmitted diseases (no later than 2 hours after intimacy), a 0.05% solution (5 to 10 ml) is injected into the vagina for 3 minutes.



Chemical compound
IUPAC	N",N"""""-hexane-1,6-diylbis[ N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
Gross- formula	C 22 H 30 Cl 2 N 10
Mol. weight	505.446 g/mol
CAS	55-56-1
PubChem
DrugBank	APRD00545
Classification
ATX	A01AB03 B05CA02, D08AC02, D09AA12, R02AA05, S01AX09, S02AA09, S03AA04
Dosage forms
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(Chlorhexidinum) - 1,6-Di-(para-chlorophenylguanido)-hexane. Available in the form of bigluconate (Chlorhexidini bigluconas). Antiseptic.

International name (INN) and synonyms

Synonyms and trademarks: Desihand, Desiscrub, Dezin, Gibitan, Hexicon, CONDICLEAN, Sebidin, Hibitan, Abacil, Biotensid, Chlorohex, Corsodyl, Fimeil, Hexadol, Hexol, Hibitane, Nolvasan, Plivasept, Rotersept, Sebidin, Septalone, Soretol, Sterilone and etc.

Pharmacological properties of the substance

Chemically, it is a dichlorine-containing biguanide derivative. The structure is very close to bigumal.

Chlorhexidine is an antiseptic drug, active against gram-positive and gram-negative bacteria ( Treponema pallidum, Chlamydia spp., Ureaplasma spp., Neisseria gonorrhoeae, Gardnerella vaginalis, Bacteroides fragilis, except for Mycobacterium tuberculosis); protozoa ( Trichomonas vaginalis); herpes virus. Does not affect other viruses and spores. The drug is stable and after treating the skin (hands, surgical field, etc.) with it, it remains on it in a certain amount, which continues to give a bactericidal effect.

The drug retains activity in the presence of blood and pus, although somewhat reduced.

Used for treating the surgical field and the surgeon's hands, sterilizing surgical instruments, as well as for purulent-septic processes (washing surgical wounds, bladder, etc.) and for the prevention of sexually transmitted diseases (syphilis, gonorrhea, trichomoniasis). The substance chlorhexidine bigluconate is available in the form of a 20% aqueous solution. The ready-to-use drug is a less concentrated aqueous or aqueous-alcoholic solution. So, to treat the surgical field, dilute a 20% solution with 70% ethyl alcohol in a ratio of 1:40. The resulting 0.5% aqueous-alcohol solution of chlorhexidine bigluconate is treated with the surgical field 2 times with an interval of 2 minutes. To quickly sterilize instruments, use the same solution for 5 minutes. To disinfect wounds and burns, use a 0.5% aqueous solution; for hand disinfection - 0.5% alcohol solution or 1% aqueous solution. When using the drug to treat the surgeon's hands, transient dryness and itching of the skin and dermatitis are possible; The skin of the hands may also become sticky for 3 to 5 minutes.

Release form

Vaginal suppositories

one suppository contains 0.016 g of chlorhexidine bigluconate

one suppository contains 0.008 g of chlorhexidine bigluconate

Gel for local and external use 0.5%

100 g of gel contains 0.5 g of chlorhexidine bigluconate

Solution for external use 0.05%

100 ml of purified water contains a solution of chlorhexidine bigluconate 20% - 0.25 ml

Directions for use and doses

Chlorhexidine is used externally and locally as a prophylactic and therapeutic agent. 0.05, 0.2 and 0.5% aqueous solutions are used in the form of irrigation, rinsing and application - 5-10 ml of solution is applied to the affected surface of the skin or mucous membranes with an exposure of 1-3 minutes 2-3 times a day (on a tampon or by irrigation ). Treatment of medical instruments and working surfaces is carried out with a clean sponge moistened with an antiseptic solution, or by soaking. For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Using a nozzle, insert the contents of the bottle into the urethra of men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml) for 2-3 minutes. Treat the skin of the inner thighs, pubis, and genitals. After the procedure, do not urinate for 2 hours. Complex treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of a 0.05% solution of chlorhexidine bigluconate into the urethra 1-2 times a day, the course is 10 days, procedures are prescribed every other day. Intravaginally, 1 suppository 3-4 times a day for 7-20 days, depending on the nature of the disease. A rinse solution and a topical gel are usually prescribed 2-3 times a day. Plaster: remove the protective film from the surface of the plaster without touching the bandage pad with your fingers, and apply it to the damaged area of the skin. Press the edges of the patch with your fingers so that the sticky part of the patch holds the bandage in place.

Application

Vaginal suppositories

treatment of vaginal infections (bacterial vaginosis, trichomoniasis, nonspecific, mixed infections)
emergency individual prevention of sexually transmitted infections (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis)
sanitation of the birth canal to prepare for delivery and management of the postpartum period in women at risk for infectious and inflammatory complications

Vaginal suppositories can be used in all trimesters of pregnancy and lactation. Vaginal suppositories have a gentle effect on the mucous membrane, preserving normal vaginal microflora.

Vaginal suppositories (children's form)

local treatment

Gel for local and external use 0.5%

treatment of wounds, abrasions, scratches, burns, scratches
treatment and prevention of skin and mucous membrane infections
use in dentistry (gingivitis, stomatitis and periodontitis)
acne treatment (as part of complex therapy)
skin care after cosmetic procedures (piercing, tattooing, depilation)

Solution for external use 0.05%

washing wounds, abrasions, scratches, burns, scratching insect bites
application in dentistry (gingivitis, stomatitis and periodontitis)
treatment of ENT diseases (pharyngitis, laryngitis, tonsillitis, otitis)
protection against germs in public places, outdoors
prevention of sexually transmitted infections

1% aqueous solution of chlorhexidine bigluconate

for general disinfection of premises, sanitary equipment, etc.

Contraindications

Hypersensitivity to the components of the drug, dermatitis, allergic reactions. The simultaneous use of iodine preparations is undesirable to avoid the development of dermatitis. You should not use chlorhexidine solutions for treating the conjunctiva and for rinsing cavities.

Carefully

Use with caution in children.

Chlorhexidine is used to prevent STDs only as an emergency measure (broken condom, casual sexual contact). Regular and repeated instillations of chlorhexidine into the urethra can cause chemical burns to the latter (especially with individual hypersensitivity to the drug), which can ultimately lead to such a serious complication as urethral stricture.

Side effect

Vaginal suppositories. Allergic reactions and itching are possible, which disappear after discontinuation of the drugs. Bleeding of varying intensity may occur.

Gel. Allergic reactions, dry skin, itching, discoloration of the skin, dermatitis, stickiness of the skin of the hands (3-7 minutes) when using the gel, photosensitivity (the phenomenon of increasing the sensitivity of the body (usually the skin and mucous membranes) to the action of ultraviolet radiation). In the treatment of gingivitis - staining of tooth enamel, tartar deposits, taste disturbance. Enamel staining and tartar deposits occur with prolonged use of the drug.

Solution. It extremely rarely causes allergic reactions, itching, which disappear after discontinuation of the drug

Interaction with other drugs

Chlorhexidine is incompatible with detergents containing anionic group (saponins, sodium lauryl sulfate, sulfonic acid, sodium carboxymethylcellulose) and soaps. The presence of soap can inactivate chlorhexidine, so before using the drug, any remaining soap must be thoroughly rinsed off.

Ethanol enhances the effectiveness of the drug.

special instructions

Vaginal suppositories. Toilet of the external genitalia does not affect the effectiveness and tolerability of vaginal suppositories, since the drug is used intravaginally.

Solution and gel. Avoid getting the drug inside the wound of patients with open traumatic brain injury, spinal cord injuries, or perforation of the eardrum. If the solution gets on the mucous membranes of the eye, they should be quickly and thoroughly rinsed with water. Safety Data Sheets (MSDS) for chlorhexidine digluconate.

Contact of hypochlorite bleaches on fabrics that have previously been in contact with chlorhexidine-containing products may cause brown stains. The bactericidal effect increases with increasing solution temperature. At temperatures above 100 °C the drug partially decomposes.

Storage

In a place protected from light at room temperature. For individual prevention of sexually transmitted diseases, it is available in the form of a 0.05% solution in a special polymer package of 100 ml.

Individual dosage forms

Similar drugs

The closest analogue of chlorhexidine in terms of purpose and method of use is

Chlorhexidine Bigluconate 0.05 is an antiseptic; depending on the concentration, it exhibits a bacteriostatic or bactericidal effect against gram-positive and gram-negative bacteria.

Active against vegetative forms of gram-negative and gram-positive bacteria, as well as yeast, dermatophytes and lipophilic viruses. It affects bacterial spores only at elevated temperatures. Cleanses and disinfects the skin without causing damage.

In the presence of various organic substances, secretions, pus and blood, it retains its activity (slightly reduced).

Different concentrations of alcohol and aqueous solutions affect the bacteriostatic and bactericidal effects of the drug.

At a concentration of 0.01% it has a bacteriostatic effect, and at a concentration of 0.05% Chlorhexidine Bigluconate has a fungicidal effect. The drug also acts on bacterial spores at elevated temperatures.

Indications for use

What does Chlorhexidine Bigluconate 0.05 help with? According to the instructions, the drug is prescribed in the following cases:

genital herpes, syphilis, gonorrhea, trichomoniasis, ureaplasmosis, chlamydia (for the prevention of sexually transmitted infections; no later than 2 hours after sexual intercourse);
cracks, abrasions (for disinfecting the skin);
infected burns, purulent wounds;
fungal and bacterial diseases of the skin and mucous membranes of the genitourinary organs;
alveolitis, periodontitis, aphthae, stomatitis, gingivitis (for irrigation and rinsing).

Instructions for use of Chlorhexidine Bigluconate 0.05, dosage

The solution is used topically or externally 2 to 5 times a day. To treat minor abrasions, scratches, and cuts, use a cotton-gauze swab soaked in the solution to carefully wipe the affected area with blotting movements.

To treat burns, poorly healing wound surfaces or deep cuts, the solution can be used under an occlusive dressing, changing it as it dries, but at least 3 times a day. If pus is released from the wound surface, then before using the solution, the area should be thoroughly treated several times with a solution of hydrogen peroxide.

For the treatment of gynecological diseases of the vagina and cervix, Chlorhexidine Bigluconate solution is used for douching and tampons. The duration of the course of drug treatment is determined by the doctor individually, depending on the diagnosis.

For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. Using a nozzle, insert the contents of the bottle into the urethra of men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml) for 2-3 minutes. Treat the skin of the inner thighs, pubis, and genitals. After the procedure, do not urinate for 2 hours.

Complex treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of a 0.05% solution of Chlorhexidine bigluconate into the urethra 1-2 times a day, the course is 10 days, procedures are prescribed every other day.

Chlorhexidine Bigluconate for gargling

In ENT practice it is used for sore throat, pharyngitis, tonsillitis. If you have a sore throat, you should gargle with a solution of 0.2% or 0.5%.

Before using Chlorhexidine as a gargle, it is recommended to rinse your mouth thoroughly with warm water. Next, gargling for a sore throat is carried out as follows: you should take 10–15 ml (about a tablespoon) of the solution, which can be used to gargle for about 30 seconds. You can repeat these steps one more time.

After rinsing, it is advisable not to take food or liquid for 1 hour. Your doctor will tell you how to gargle with Chlorhexidine, as well as how many times a day you need to do this procedure for your throat, taking into account your individual symptoms.

If you feel a burning sensation when rinsing your mouth, then most likely the solution is too concentrated. The highest permissible concentration is no more than 0.5%.

special instructions

Remains active in the presence of blood and organic substances.

Do not allow contact with the eyes (with the exception of a special dosage form intended for washing the eyes), as well as contact with the meninges and the auditory nerve.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Chlorhexidine Bigluconate 0.05:

Allergic reactions - skin rash, dry skin, itching, dermatitis, stickiness of the skin of the hands (within 3-5 minutes), photosensitivity.
In the treatment of gingivitis – staining of tooth enamel, tartar deposits, taste disturbance.

Contraindications

It is contraindicated to prescribe Chlorhexidine Bigluconate 0.05 in the following cases:

hypersensitivity to chlorhexidine.

Overdose

In case of accidental ingestion, it is practically not absorbed (gastric lavage should be done using milk, raw egg, gelatin).

If necessary, symptomatic treatment is carried out.

Analogues of Chlorhexidine Bigluconate 0.05, price in pharmacies

If necessary, you can replace Chlorhexidine Bigluconate 0.05 with an analogue of the active substance - these are the following drugs:

Hexicon,
Amident.

Similar in action:

Miramistin;
Iodonate;

When choosing analogues, it is important to understand that the instructions for use of Chlorhexidine Bigluconate 0.05, the price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Chlorhexidine bigluconate solution 0.05% 100ml - from 15 to 18 rubles, according to 702 pharmacies.

Store in a place protected from light and moisture, at temperatures up to 25 °C. Keep away from children. Shelf life – 2 years.

Conditions for dispensing from pharmacies - without a prescription.

Due to its effectiveness, safety and low price, Chlorhexidine 0.05 solution has long been one of the most popular local antiseptics. The product is used to treat skin, mucous membranes in case of violation of their integrity and infection, as well as medical instruments, furniture and premises. It is valuable that the drug provides a long-lasting (up to 18 hours) disinfecting effect.

Chlorhexidine.

ATX

D08AC02 Chlorhexidine.

Release forms and composition

In Russia and abroad, the pharmaceutical industry produces drugs with the active ingredient chlorhexidine bigluconate in a variety of forms. This:

aqueous solutions of 0.05%, 0.2%, 1%, 5% and 20%;
alcohol solutions and sprays 0.5%;
vaginal suppositories (Hexicon suppositories) 8 and 16 mg;
gels;
capsules;
lollipops;
lozenges;
creams;
ointments;
bactericidal patches.

For individual use, the product is produced in containers of 2, 5, 10, 70, 100 and 500 ml. For use in medical institutions - in 2 liter bottles.

Solution

An aqueous solution of chlorhexidine bigluconate with a concentration of 0.05% is a clear liquid without sediment. 1 ml of medication contains 0.5 mg of active substance. An auxiliary component is purified water. Solutions of 70 or 100 ml are packaged in plastic or glass bottles. Some of them are equipped with dispensers for ease of use. Dropper tubes made of polyethylene contain 2, 5 or 10 ml of antiseptic.

Spray

In 1 bottle or bottle with a spray cap or nozzle - 5 g of chlorhexidine bigluconate. Auxiliary components: 95% ethanol diluted with purified water. It is a clear, colorless liquid that may have a slight pearlescent tint. Gives off the smell of alcohol. Spray with a 0.5% solution is packaged in 70 and 100 ml.

pharmachologic effect

The medication belongs to the group of antiseptics and disinfectants. The product has the following effect:

antiseptic;
bactericidal;
mild anesthetic;
fungicidal (leading to the destruction of fungi).

The nature of the effect of the drug depends on the amount of the active substance. 0.01% solutions provide a bacteriostatic effect, preventing the proliferation of microorganisms. Liquid products with a concentration of chlorhexidine digluconate of more than 0.01% have a bactericidal effect, destroying pathogens at an air temperature of +22°C in 1 minute. 0.05% solutions produce a fungicidal effect within 10 minutes, and at 1% concentration a virucidal effect occurs against herpes pathogens.

Cations of the active substance of the drug destroy the cell membranes of pathogens, which soon die. However, some forms of bacteria, spores of microbes and fungi, and many types of viruses are resistant to the product. The effective action of the drug is manifested against the following pathogens of infectious diseases:

Bacteroides fragilis;
Chlamydia spp.;
Gardnerella vaginalis;
Neisseria gonorrhoeae;
Treponema pallidum;
Trichomonas vaginalis;
Ureaplasma spp.;
Pseudomonas and Proteus spp. (chlorhexidine bigluconate has a moderate effect on some strains of these pathogens).

Due to its long-term disinfecting effect, the medication is widely used in surgical practice as an antiseptic treatment. The drug exhibits slightly less bactericidal activity on the skin and mucous membranes in the presence of blood, pus, and physiological fluids secreted by the body.

Pharmacokinetics

The solution, intended for external use, does not enter the bloodstream and does not have a systemic effect. If accidentally swallowed, it is practically not absorbed from the digestive tract and is almost completely excreted in the feces.

Indications for use

In gynecology - for treatment and prevention:

itching of the vulva;
cervical erosion;
ureaplasmosis;
chlamydia;
trichomoniasis;
trichomonas colpitis;
gonorrhea;
syphilis.

In dentistry and ENT practice, in addition to postoperative treatments and disinfection of dentures, indications for the use of the product are the following common diseases:

stomatitis;
periodontitis;
gingivitis;
alveolitis;
aphthae;
angina.

The solution can also be used as a local antiseptic:

for treating burns and wounds;
when disinfecting the skin of operated patients and surgical department personnel;
for the purpose of disinfecting medical equipment, instruments, devices that cannot be subjected to heat treatment.

Contraindications

The drug must not be used:

people with individual hypersensitivity to the active substance of the drug;
in the presence of dermatitis;
in case of allergic reactions due to contact with the solution.

How to use Chlorhexidine 0.05?

Skin injuries, burns: moisten a sterile napkin with a disinfectant solution and apply to the sore spot for 2-3 minutes (it is not necessary to fix it with an adhesive plaster or bandage). Apply applications 2-4 times a day.
Sore throat, pharyngitis, laryngitis, diseased teeth, abscesses, fistulas, inflamed gums after periodontal surgery, injuries to the oral mucosa: first remove possible food debris with a small amount of warm water, then take 1-2 tbsp. solution and rinse your mouth and throat for about 1 minute 3-4 times a day. Under no circumstances should you swallow Chlorhexidine! After rinsing, do not drink or eat for 1 hour.
Inflammatory processes of the female genital area: douche in a lying position, squeezing 0.5-1 ml of the product into the vagina from a plastic container. Then you should lie down for 8-10 minutes. Perform 2-3 procedures daily for 1-1.5 weeks.
Urinary tract diseases: inject 2-3 ml of solution into the urethra 2-3 times a day. The course of treatment is 5-10 days.
Prevention of genital infections: first urinate, then inject 2-3 ml of solution into the urethra with a syringe without a needle, for women - 5-10 ml and into the vagina. Treatment of the skin around the external genitalia is mandatory. You can urinate only after 2 hours. The preventive measure is effective if taken no later than 2 hours after the end of unprotected sexual intercourse or the integrity of the condom is broken.

How to dilute for rinsing?

0.05% Chlorhexidine solution is completely ready for external use. At higher concentrations, the drug should be mixed with boiled water at room temperature in the following proportions:

0,2% - 1:4;
0,5% - 1:10;
1% - 1:20;
5% - 1:100.

Can I wash my eyes?

The medication is not intended for use in ophthalmic practice. Do not allow Chlorhexidine to get into your eyes. If this happens accidentally, you need to rinse them with running water and then drip in a solution of sodium sulfacyl (Albucid).

Taking the drug for diabetes mellitus

Patients can use the medication in any form. However, when purchasing lollipops and lozenges, you should make sure that they contain a sweetener and not sucrose.

Side effects of Chlorhexidine 0.05

Undesirable consequences of using the drug appear in rare cases and quickly disappear after its discontinuation. This:

allergic reactions - itching, redness of the skin, rash, dermatitis in areas of contact with the solution;
short-term stickiness of the skin of the hands;
dry skin;
photosensitivity (increased sensitivity to sunlight);
darkening of tooth enamel, increased formation of tartar, distortion of taste (with frequent rinsing of the mouth);
shortness of breath, anaphylactic shock (extremely rare).

special instructions

Contact of the solution with the meninges, open injuries of the brain and spinal cord, perforated eardrum, and auditory nerve is unacceptable.

The antiseptic is not intended for the treatment of rhinitis, sinusitis, otitis.

The product should not be used for viral infections (for this purpose, you can use, for example, Miramistin).

Solutions with concentrations higher than 0.2% are prohibited from treating mucous membranes and open skin injuries.

Chlorhexidine is a medicine, not a hygiene product. The solution should not be used for daily care of the oral cavity or genitals, as allergic reactions may occur and dysbacteriosis may develop.

It is forbidden to dilute the drug with mineral water or add baking soda to it.

The antibacterial effect of the drug is enhanced by heating, however, at a temperature of about +100°C, chlorhexidine digluconate is destroyed and almost completely loses its medicinal properties.

Rinsing with a solution is effective as an adjuvant in complex therapy. But it is impossible to destroy pathogenic bacteria with just one antiseptic; antibiotics should be taken at the same time.

For children, preparations containing chlorhexidine bigluconate are produced with the “D” marking, for example, Hexicon D suppositories. Lozenges and lozenges for resorption can only be given to a child over 5 years of age to avoid swallowing.

The solution does not damage products made of metals, plastics, or glass. However, brown spots appear on fabrics that have come into contact with Chlorhexidine when bleached with hypochlorite agents.

If the drug enters the body, it affects the results of anti-doping control.

Can children take Chlorhexidine 0.05?

Since there is no scientific evidence of the complete safety of external and local use of the drug, children under 7 years of age should not be treated with it. Particular care is required when rinsing the mouth and throat to prevent the child from swallowing the solution.

Use during pregnancy and lactation

The product can be used during pregnancy and breastfeeding, because when rinsing or using a nebulizer, the medication does not enter the circulatory system. However, douching with a solution is prohibited, since during this procedure you can accidentally introduce an infection into the vagina. Many doctors recommend using safer Lizobact lozenges and Hexicon suppositories during pregnancy instead of Chlorhexidine.

Overdose of Chlorhexidine 0.05

If the drug is used according to the instructions, an overdose is impossible. In case of accidental ingestion of a solution in large quantities, the stomach should be rinsed and the victim should be given enterosorbent.

Interaction with other drugs

The medication is incompatible with soap, detergents, alkalis and other anionic substances (colloidal solutions, gum arabic, carboxymethylcellulose, sodium lauryl sulfate).

The product is compatible with substances that have a cationic group (cetrimonium bromide, benzalkonium chloride, etc.).

Interacting with carbonates, chlorides, sulfates, phosphates, borates, citrates, the drug forms poorly soluble compounds.

It is prohibited to use Chlorhexidine for rinsing together with iodine, Lugol's solution, or other disinfectants.

The medication increases the sensitivity of bacterial flora to Neomycin, Kanamycin, Levomycetin, and cephalosporin antibiotics.

Ethyl alcohol enhances the effectiveness of the drug.

Analogs

Chlorhexidine can be replaced by drugs of the same or similar effect. This:

Amident;
Anzibel;
Anti-Angin;
Baktosin;
Hexicon;
Hexoral;
Drill;
Curasept;
Miramistin;
Mucosanin;
Pantoderm;
hydrogen peroxide;
Plivasept;
Sebidin;
Furacilin;
Chlorophyllipt;
Citeal;
Eludril et al.

Conditions for dispensing from a pharmacy

Available without a prescription.

How much does Chlorhexidine 0 05 cost?

The price depends on the volume of the product, the type of material from which the container is made, transportation costs, and the category of pharmacy. The average cost of 1 bottle of 100 ml ranges from 12 to 18 rubles.

Storage conditions of the drug

The solution should be protected from daylight. Temperature range: +1…+25°С. The medication should be kept out of the reach of children.

Best before date

The pharmaceutical preparation retains its healing properties for 3 years, a diluted solution - no more than 7 days. Expired product should not be used.

Manufacturer

Companies producing drugs with chlorhexidine digluconate:

“BioPharmKombinat”, “Biogen”, “Biokhimik”, “Kemerovo Pharmaceutical Factory”, “Medsintez”, “Medkhimprom-PHFK”, “Moscow Pharmaceutical Factory” (Russia);
"Nizhpharm", "Update", "Petrospirt", "Rosbio", "Pharmaceutical Factory of St. Petersburg", "PharmVILAR", "Pharmproekt", "EKOlab", "Ergofarm", "Eskom", "Yuzhfarm" (Russia) ;
Glaxo Wellcome (Poland);
"Famar Orleans" (USA);
Nobelpharma Ilac (Türkiye);
"Herkel" (Netherlands);
AstraZeneca (UK);
"Curaprox" (Switzerland);
"Giffrer-Barbeza" (France).

Chlorhexidine

Chlorhexidine or Miramistin?

In this article you can read the instructions for use of the drug Chlorhexidine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Chlorhexidine in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Chlorhexidine analogues in the presence of existing structural analogues. Use for the treatment of candidiasis (thrush), sore throat, stomatitis and gingivitis, as well as for surface treatment in adults, children, as well as during pregnancy and lactation. How to gargle with chlorhexidine correctly.

Chlorhexidine- antiseptic. Chlorhexidine is active against vegetative forms of gram-negative and gram-positive bacteria, as well as yeast, dermatophytes and lipophilic viruses. It affects bacterial spores only at elevated temperatures. Cleanses and disinfects the skin without causing damage.

Pharmacokinetics

Systemic absorption during intravaginal use is negligible.

Indications

treatment of wounds, burns and surfaces; disinfection of the patient's skin;
cleaning the hands of the surgeon, medical staff and the surgical field before diagnostic procedures and surgery;
disinfection of working surfaces of instruments (including thermometers) and equipment, the heat treatment of which is undesirable;
rinsing for sore throat, gingivitis, stomatitis, periodontitis, alveolitis, disinfection of removable dentures;
prevention of sexually transmitted infections (chlamydia, ureaplasmosis, trichomoniasis, gonorrhea, syphilis, genital herpes and others);
prevention of infectious and inflammatory complications in obstetrics and gynecology (before surgical treatment of gynecological diseases, before childbirth and abortion, before and after installation of an intrauterine device (IUD), before and after diathermocoagulation of the cervix, before intrauterine examinations);
treatment of bacterial vaginosis, colpitis (including nonspecific, mixed, trichomonas).

Release forms

Solution for local and external use (bigluconate) 0.05%, 0.2%, 1%, 5%.

Vaginal suppositories 8 mg and 16 mg.

Spray for external use (alcohol) 0.5%.

Instructions for use and method of application

The dose and route of administration depend on the indications and dosage form of chlorhexidine.

As rinses for the mouth, throat and oropharynx, solutions specially designed for this purpose are used without dilution.

Candles

Intravaginally. Having previously freed the suppository from the contour cell packaging, it is inserted into the vagina in a supine position.

For treatment: 1 suppository 2 times a day for 7-10 days. If necessary, it is possible to extend the course of treatment to 20 days.

For the prevention of sexually transmitted infections: 1 suppository no later than 2 hours after sexual intercourse.

Side effect

allergic reactions;
itchy skin.

Contraindications

hypersensitivity to chlorhexidine.

special instructions

Remains active in the presence of blood and organic substances. Do not allow chlorhexidine to get into the eyes (with the exception of a special dosage form intended for washing the eyes), as well as contact with the meninges and the auditory nerve.

Drug interactions

Chlorhexidine is not compatible with soap, as well as with detergents containing an anionic group (saponins, sodium lauryl sulfate, sodium carboxymethylcellulose).

Compatible with drugs containing a cationic group (cetrimonium bromide, benzalkonium chloride).

Analogues of the drug Chlorhexidine

Structural analogues of the active substance:

Amident;
Hexicon;
Hexicon D;
Hibiscrub;
Categhel C;
Plivasept;
Plivasept P;
Chlorhexidine bigluconate;
Chlorhexidine Gifrer;
Citeal.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.