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Vitamin D3 aqueous solution instructions. Aquadetrim vitamin D3: instructions for use, reviews and recommendations from doctors

Instructions for medical use of the drug

Aquadetrim vitamin D3

Tradename

Aquadetrim vitamin D3

International nonproprietary name

Colecalciferol

Dosage form

Oral drops 15,000 IU/ml

1 ml of solution (30 drops) contains

active substance - cholecalciferol 15,000 IU,

excipients: macrogol glyceryl ricinoleate, sucrose (250 mg), sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol (15 mg), purified water.

Description

Colorless, transparent or slightly opalescent liquid with an anise odor.

Pharmacotherapeutic group

Vitamins. Vitamin D and its derivatives.

ATS code A11CC 05

Pharmacological properties

Pharmacokinetics

An aqueous solution of vitamin D3 is better absorbed than an oil solution (which is important when used in premature infants). After oral administration, cholecalciferol is absorbed in the small intestine by passive diffusion of 50 to 80% of the dose.

Absorption is rapid (in the distal small intestine), enters the lymphatic system, enters the liver and the general bloodstream. In the blood it binds to alpha2-globulins and partially to albumins. Accumulates in the liver, bones, skeletal muscles, kidneys, adrenal glands, myocardium, and adipose tissue. TCmax (period of maximum concentration) in tissues is 4-5 hours, then the concentration of the drug decreases slightly, remaining at a constant level for a long time. In the form of polar metabolites, it is localized mainly in the membranes of cells and microsomes, mitochondria and nuclei. Penetrates the placental barrier and is excreted in breast milk.

Deposited in the liver.

Metabolized in the liver and kidneys: in the liver it is converted into an inactive metabolite calcifediol (25-dihydrocholecalciferol), in the kidneys - from calcifediol it is converted into an active metabolite calcitriol (1,25-dihydroxycholecalciferol) and an inactive metabolite 24,25-dihydroxycholecalciferol. Subject to enterohepatic recirculation.

Vitamin D and its metabolites are excreted in the bile, and a small amount is excreted in the kidneys. Cumulates.

Pharmacodynamics

Aquadetrim vitamin D3 is an antirachitic drug. The most important function of Aquadetrim vitamin D3 is the regulation of calcium and phosphate metabolism, which promotes mineralization and skeletal growth. Vitamin D3 is the natural form of vitamin D, which is formed in humans in the skin under the influence of sunlight. Plays a significant role in the absorption of calcium and phosphates from the intestines, in the transport of mineral salts and in the process of bone calcification, and also regulates the reabsorption of calcium and phosphates by the kidneys. Calcium ions are involved in a number of important biochemical processes that determine the maintenance of muscle tone of skeletal muscles, in the conduction of nervous stimulation, and in the process of blood clotting. Aquadetrim vitamin D3 stimulates the production of lymphokines.

Indications for use

Prevention and treatment

Hypo- and avitaminosis of vitamin D (states of increased need for vitamin D in the body due to nephrogenic osteopathy, inadequate and unbalanced nutrition, malabsorption syndrome, insufficient insolation, hypocalcemia, hypophosphatemia, renal failure, liver cirrhosis, pregnancy and lactation)

Hypocalcemic tetany

Osteomalacia and bone diseases with metabolic disorders (hypoparathyroidism and pseudohypoparathyroidism)

As part of complex therapy

Osteoporosis in postmenopausal women

Rickets-like diseases

Directions for use and doses

The drug is taken orally with a small amount of liquid

1 drop contains about 500 IU of vitamin D3.

Prophylactic doses:

full-term newborns from 4 weeks of life to 2-3 years of life with proper care and sufficient exposure to fresh air - 500 IU (1 drop) per day;

premature newborns from 4 weeks of life, as well as twins, infants in poor living conditions - 1000 IU (2 drops) per day for one year. In the summer, you can limit the dose to 500 IU (1 drop) per day. The duration of therapy is up to 2-3 years of life;

pregnant women - a daily dose of 500 IU of vitamin D3 for the entire period of pregnancy, or 1000 IU/day from the 28th week of pregnancy;

For postmenopausal women - 500 - 1000 IU (1-2 drops) per day, for 2-3 years, the doctor decides on the need for repeated courses of therapy.

Therapeutic doses:

for rickets, start with 2000 IU for 3-5 days, then, if well tolerated, the dose is increased to an individual therapeutic dose of 2000 - 5000 IU (4-10 drops) daily, most often 3000 IU, depending on the severity of rickets (I, II , or III) and the course of the disease, for 4-6 weeks, under careful monitoring of the clinical condition and the study of biochemical parameters (calcium, phosphorus, alkaline phosphatase) of blood and urine. A dose of 5000 IU is prescribed only for pronounced bone changes.

If necessary, after a one-week break, you can repeat the course of treatment. Treatment is carried out until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500 - 1500 IU/day. The duration of the course of treatment and prevention is determined by the doctor;

for rickets-like diseases, 10,000 - 20,000 IU per day (20 - 40 drops), depending on age, weight and severity of the disease, under the control of biochemical blood parameters and urine analysis. The course of treatment is 4-6 weeks. The doctor decides about the need for repeated courses of therapy;

for osteomalacia and postmenopausal osteoporosis as part of complex therapy, 500 - 1000 IU (1-2 drops) per day.

The dosage is usually prescribed taking into account the amount of vitamin D supplied in other foods.

Side effects

In cases of rarely observed individual hypersensitivity to vitamin D3 or as a result of using too high doses over a long period, hypervitaminosis D3 may occur:

Mental disorders, including depression

Loss of appetite, nausea, vomiting, dry mouth, constipation

Headaches, muscle and joint pain

Weight loss

Polyuria

Increased calcium levels in the blood and urine

Kidney stone formation and soft tissue calcification

Contraindications

Hypersensitivity to the components of the drug, especially benzyl alcohol

Hypervitaminosis D

Liver and kidney failure

Elevated levels of calcium and phosphorus in the blood and urine

Calcium kidney stones

Sarcoidosis

Neonatal period up to 4 weeks

Drug interactions

Antiepileptic drugs, rifampicin, cholestyramine, reduce the reabsorption of vitamin D3.

Use simultaneously with thiazide diuretics increases the risk of hypercalcemia.

Simultaneous use with cardiac glycosides may enhance their toxic effect (increases the risk of heart rhythm disturbances).

The toxic effect is weakened by vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin.
Under the influence of barbiturates (including phenobarbital), phenytoin and primidone, the need for colecalciferol can significantly increase (increase the metabolic rate).
Long-term therapy with the simultaneous use of aluminum and magnesium-containing antacids increases their concentration in the blood and the risk of intoxication (especially in the presence of chronic renal failure).
Calcitonin, derivatives of etidronic and pamidronic acids, plicamycin, gallium nitrate and glucocorticosteroids reduce the effect.
Cholestyramine, colestipol and mineral oils reduce the absorption of fat-soluble vitamins in the gastrointestinal tract and require an increase in their dosage.
Increases the absorption of phosphorus-containing drugs and the risk of hyperphosphatemia. When used simultaneously with sodium fluoride, the interval between doses should be at least 2 hours; with oral forms of tetracyclines - at least 3 hours.
Concomitant use with other vitamin D analogues increases the risk of developing hypervitaminosis.

special instructions

Avoid overdose.

Individual provision of a specific need must take into account all possible sources of this vitamin.

Too high doses of vitamin D3, used over a long period of time or shock doses, can cause chronic hypervitaminosis D3.

Determining a child’s daily need for vitamin D and the method of its use should be determined by a doctor individually and each time subject to correction during periodic examinations, especially in the first months of life.

Use cautiously in immobilized patients.

Do not use calcium supplements in high doses simultaneously with vitamin D3.

Treatment is carried out under periodic monitoring of the level of calcium and phosphorus in the blood and urine.

Caution is necessary when prescribing the drug to elderly people, since in this category of people calcium deposition in the lungs, kidneys and blood vessels increases.

Use with caution in people with diabetes.

Pregnancy and lactation period

During pregnancy, Vitamin D3 should not be used in high doses of 2,000 IU due to the possibility of teratogenic effects in case of overdose.

Vitamin D3 should be prescribed with caution during lactation, since the drug taken in high doses by the mother can cause overdose symptoms in the child.

Features of the drug's influence on the ability to drive

vehicle or potentially dangerous machinery

Does not affect

Overdose

Symptoms: anxiety, thirst, loss of appetite, nausea, vomiting, diarrhea, constipation, intestinal colic, polyuria. Frequent symptoms are headaches, muscle and joint pain, mental disorders, including depression, stupor, ataxia and progressive weight loss. Renal dysfunction develops with albinuria, erythrocyturia and polyuria, increased potassium loss, hyposthenuria, nocturia and increased blood pressure. In severe cases, clouding of the cornea may occur, less commonly swelling of the optic nerve papilla, inflammation of the iris, and even the development of cataracts. Kidney stones may form and calcification of soft tissues, including blood vessels, heart, lungs and skin, occurs. Cholestatic jaundice rarely develops.

Treatment: discontinuation of the drug, drinking plenty of fluids, symptomatic therapy.

Release form and packaging

Storage conditions

Store in a place protected from light at temperatures from 5°C to 25°C. Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Conditions for dispensing from pharmacies

Over the counter

Manufacturer

Medana Pharma JSC

98-200 Sieradz, st. W. Loketka 10, Poland

Registration Certificate Holder

"Khimpharm" JSC, Kazakhstan

Address of the organization that accepts claims from consumers regarding the quality of products (products) on the territory of the Republic of Kazakhstan

JSC "Khimpharm", Shymkent, REPUBLIC OF KAZAKHSTAN,

st. Rashidova, w/n, t/f: 560882

Phone number 7252 (561342)

Fax number 7252 (561342)

E-mail address [email protected]

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Aquadetrim vitamin D3 is an antirachitic drug.

The active ingredient of the drug Aquadetrim is colecalciferol (vitamin D3) - a regulator of calcium and phosphate metabolism. Synthetic colecalciferol is identical to the endogenous one, which is formed in the body under the influence of sunlight.

Colecalciferol in the Aquadetrim preparation has more pronounced physiological activity compared to ergocalciferol (vitamin D2). Under the influence of the drug, the metabolism of calcium and phosphates in the human body is normalized. This contributes to the proper formation of the bone skeleton and the preservation of bone tissue structure.

Instructions for medical use of the drug Aquadetrim vitamin D3

Tradename

Aquadetrim vitamin D3

International nonproprietary name

Colecalciferol

Dosage form

Oral drops 15,000 IU/ml

Compound

1 ml of solution (30 drops) contains

active substance - cholecalciferol 15,000 IU,

excipients: macrogol glyceryl ricinoleate, sucrose (250 mg), sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol (15 mg), purified water.

Description

Colorless, transparent or slightly opalescent liquid with an anise odor.

Pharmacotherapeutic group

Vitamins. Vitamin D and its derivatives.

ATS code A11CC 05

Pharmacological properties

Pharmacokinetics

Deposited in the liver.

Vitamin D and its metabolites are excreted in the bile, and a small amount is excreted in the kidneys. Cumulates.

Pharmacodynamics

Indications for use of the drug Aquadetrim vitamin D3

Prevention and treatment:

Hypocalcemic tetany

Osteomalacia and bone diseases with metabolic disorders (hypoparathyroidism and pseudohypoparathyroidism)

As part of complex therapy

Osteoporosis in postmenopausal women

Rickets-like diseases

Method of administration and dosage of the drug Aquadetrim vitamin D3

The drug is taken orally with a small amount of liquid

1 drop contains about 500 IU of vitamin D3.

Preventive doses of Aquadetrim vitamin D3:

full-term newborns from 4 weeks of life to 2-3 years of life with proper care and sufficient exposure to fresh air - 500 IU (1 drop) per day;

pregnant women - a daily dose of 500 IU of vitamin D3 for the entire period of pregnancy, or 1000 IU/day from the 28th week of pregnancy;

For postmenopausal women - 500 - 1000 IU (1-2 drops) per day, for 2-3 years, the doctor decides on the need for repeated courses of therapy.

Therapeutic doses of Aquadetrim vitamin D3:

for osteomalacia and postmenopausal osteoporosis as part of complex therapy, 500 - 1000 IU (1-2 drops) per day.

The dosage is usually prescribed taking into account the amount of vitamin D supplied in other foods.

Side effects of the drug Aquadetrim vitamin D3

In cases of rarely observed individual hypersensitivity to vitamin D3 or as a result of using too high doses over a long period, hypervitaminosis D3 may occur:

Mental disorders, including depression

Loss of appetite, nausea, vomiting, dry mouth, constipation

Headaches, muscle and joint pain

Weight loss

Polyuria

Increased calcium levels in the blood and urine

Kidney stone formation and soft tissue calcification

Contraindications to Aquadetrim vitamin D3

Hypersensitivity to the components of the drug, especially benzyl alcohol

Hypervitaminosis D

Liver and kidney failure

Elevated levels of calcium and phosphorus in the blood and urine

Calcium kidney stones

Sarcoidosis

Neonatal period up to 4 weeks

Drug interactions

Antiepileptic drugs, rifampicin, cholestyramine, reduce the reabsorption of vitamin D3.

Use simultaneously with thiazide diuretics increases the risk of hypercalcemia.

Simultaneous use with cardiac glycosides may enhance their toxic effect (increases the risk of heart rhythm disturbances).

special instructions

Avoid overdose of Aquadetrim vitamin D3.

Individual provision of a specific need must take into account all possible sources of this vitamin.

Too high doses of vitamin D3, used over a long period of time or shock doses, can cause chronic hypervitaminosis D3.

Use cautiously in immobilized patients.

Do not use calcium supplements in high doses simultaneously with vitamin D3.

Treatment is carried out under periodic monitoring of the level of calcium and phosphorus in the blood and urine.

Caution is necessary when prescribing the drug to elderly people, since in this category of people calcium deposition in the lungs, kidneys and blood vessels increases.

Use with caution in people with diabetes.

Pregnancy and lactation period

During pregnancy, Vitamin D3 should not be used in high doses of 2,000 IU due to the possibility of teratogenic effects in case of overdose.

Vitamin D3 should be prescribed with caution during lactation, since the drug taken in high doses by the mother can cause overdose symptoms in the child.

Features of the drug's influence on the ability to drive

vehicle or potentially dangerous machinery

Does not affect

Overdose of Aquadetrim vitamin D3

For good health and normal well-being, a person must consume vitamins and other beneficial substances every day. Vitamin D, also called calciferol, enters the body with food and is also formed in the skin under the influence of solar radiation. Calciferol deficiency is diagnosed in adults and children who spend little time walking in the sun, who eat poorly, as well as in residents of northern countries where sunny days are rare. For patients with severe hypovitaminosis, doctors often prescribe liquid vitamin D. The dosage of the drug and the course of administration are determined by a medical specialist.

The benefits of vitamin D for the human body

The vitamin is involved in the metabolism of minerals and promotes the accumulation of calcium in bone and dental tissue. Calciferol is also necessary to maintain the functioning of muscle fibers and the immune system. Without vitamins, minerals cannot be absorbed in the intestines and are completely excreted from the body in the urine. Vitamin D is important for the proper functioning of the heart muscle and thyroid gland, normalization of blood pressure and blood clotting. Even with a low content of the substance in the body, a person becomes susceptible to cardiovascular, dermatological, and oncological pathologies.

What is the difference between vitamins D 2 and D 3?

Ergocalciferol is vitamin D2, and cholecalciferol is vitamin D3. Ergocalciferol is present in the tissues of plant organisms. To get enough of it, you need to include fresh vegetables and fruits in your menu every day. The substance is found in small amounts in dairy products and cereals. Cholecalciferol is produced in the skin under the influence of sun radiation, and also enters the body with animal products.

Vitamin D 2 regulates the metabolism of calcium and phosphorus, activates the absorption of these minerals into the blood, and promotes their rapid delivery to bone tissue. Vitamin D 3 stimulates the absorption of minerals in the small intestine and ensures the transport of absorbed substances throughout the body. In the human body, cholecalciferol is converted into calcitriol, an active compound that fights malignant cells.

Ergocalciferol in the human body is broken down into several compounds, which in excess amounts can cause harm to organs and systems. Therefore, when using medications based on vitamin D, you must carefully follow the instructions and avoid overdose. It is advisable to consult your doctor before taking liquid calciferol.

Consequences of vitamin D deficiency in the human body

It is important that the concentration of calciferol in the body remains normal. Vitamin deficiency leads to extremely negative consequences. Hypovitaminosis is especially dangerous for the body of young children and pregnant women. The child's body is actively growing and developing, so it needs a large amount of useful substances. And with a lack of vitamin, the child’s development is inhibited. Severe calciferol deficiency in children leads to rickets and other pathologies of the musculoskeletal system.

Rickets, caused by a lack of vitamin D in the body, is diagnosed in people who are at home or at work all day, who rarely go out into the sun, and who live in northern regions. Calciferol deficiency in an adult is accompanied by the following symptoms:

chronic fatigue;
lethargy, weakness, poor health;
decreased performance;
slow healing of fractures;
low bone mineralization.

In a child, vitamin deficiency manifests itself with more pronounced symptoms:

bowed legs;
deformation of the chest and pelvic bones;
improper formation of the face and head, flattening of the back of the head;
low bone density;
excessive sweating;
irritability, moodiness, sleep disturbance;
late teething.

All of the above symptoms in a child indicate the development of rickets.

Daily intake of vitamin D for adults and children

People who for some reason are deficient in calciferol need to take medications based on vitamin D 3 . But when taking medications, you should remember that an excess of calciferol is just as harmful to the body as a deficiency. To avoid health problems, the vitamin should be consumed in accordance with the instructions for use. The daily dose of the drug is determined by the patient’s age, physical condition, well-being, and living conditions. But usually the dosages look like this:

a healthy adult needs no more than 600 IU of the substance per day;
for a child, depending on age - at least 400 - 500 IU;
for a pregnant woman - about 800 IU.

Women carrying a child must take vitamin D supplements. This will avoid depletion of the mother's body and the occurrence of malformations of the embryo. Also, calciferol in liquid dosage form is indicated as part of general strengthening therapy for elderly and weakly healthy people.

Liquid dosage forms of vitamin D

Pharmacies sell a huge number of vitamin D preparations from different manufacturers. Popular and effective dosage forms are:

aqueous solution for oral administration;
oil solution for oral administration;
injection.

Having entered the digestive tract, liquid vitamin D is absorbed through bile in the small intestine. The digestibility of the aqueous solution is higher than that of the oil preparation.

When treating frail and premature babies, it is better to use an aqueous solution. The fact is that in weak babies, the body does not synthesize enough bile to process the vitamin dissolved in the oil.

The best vitamin D preparations for adults and children

For children, many calciferol preparations are available, with a dosage of 400 IU.

ChildLife Organic Vitamin D 3 Drops. Cholecalciferol in drop form with berry flavor. Suitable for babies from birth.
Nordic Naturals Baby's Vitamin D 3. Vitamin dissolved in olive oil, without artificial components.
Natural Factors Vitamin D 3. Cholecalciferol dissolved in flaxseed oil.
Baby Drops Liquid Vitamin D 3 . This is the name of the most popular drug for infants in the United States, which has received many medical awards.

For adults, calciferol preparations are offered at a dosage of 1000 IU.

Nordic Naturals Vitamin D 3 Vegan. A product for strict vegetarians. Based on calciferol isolated from lichens.
Carlson Labs Super Daily D 3. Liquid vitamin for adults. Does not contain artificial components.
Garden of Life MyKind Organics Vegan D 3 Vanilla Spray. Cholecalciferol for vegans, isolated from lichens, sold in spray form.
Dr. Mercola Premium Supplements Sunshine Mist Vitamin D. High-quality product sold in spray form.

Indications and contraindications for use

Liquid vitamin D is prescribed to people with the following pathologies and characteristics of the body:

rickets;
osteoporosis;
hypovitaminosis;
liver dysfunction;
sudden weight loss, exhaustion;
diseases of the digestive tract;
pregnancy and breastfeeding;
rehabilitation after surgery;
poor diet, including vegetarian diet.

It is prohibited to take calciferol in the following cases:

with hypervitaminosis D;
with renal failure;
with sensitivity to the substance.

Pregnant women and young children should take calciferol carefully, carefully following the instructions and medical recommendations.

With an overdose of vitamin and the development of hypervitaminosis D, the following symptoms are observed:

headache;
allergic reaction;
loss of appetite;
nausea;
constipation;
thirst;
increased blood pressure;
arrhythmia;
weakness;
photophobia;
drying of mucous membranes;
metallic taste on tongue.

If the above symptoms occur, you should immediately stop taking the drug.

Features of taking liquid vitamin D by pregnant women and children

Calciferol, dissolved in oil, is prescribed for both preventive and therapeutic purposes. The medical specialist decides which drug the patient should take; he also determines the dosage and course of treatment.

At 30 weeks of gestation, a woman is prescribed 1400 IU of the vitamin. The drug should be taken every three days before giving birth. This is important for preventing rickets in a newborn baby. If a woman did not take a vitamin during pregnancy, then she must do so during breastfeeding. If a newborn baby is sick with rickets, then he is prescribed, based on the severity of the disease, from 7 to 24 drops of vitamin per day.

One drop of oil solution contains 600 IU of the substance. The oil-based drug is recommended to be given to young children in the winter months to prevent rickets. In the summer, there is no need to use the medication if the child often walks outside in the sun. A water-based vitamin is recommended for both adults and children from three weeks of age. The dosage is determined by the doctor, but it can be up to 20 drops per day.

In this article you can read the instructions for use of the drug Aquadetrim. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Aquadetrim vitamins in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Aquadetrim in the presence of existing structural analogues. Use for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns), as well as during pregnancy and breastfeeding. Composition of the drug.

Aquadetrim- a drug that regulates the metabolism of calcium and phosphorus. Vitamin D3 is an active antirachitic factor. The most important function of vitamin D is to regulate calcium and phosphate metabolism, which promotes skeletal mineralization and growth.

Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin under the influence of sunlight. Compared to vitamin D2, it is characterized by 25% higher activity.

Colecalciferol plays a significant role in the absorption of calcium and phosphates in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphates by the kidneys.

The presence of calcium ions in the blood in physiological concentrations ensures the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous stimulation, and regulates the process of blood coagulation.

Vitamin D is necessary for the normal functioning of the parathyroid glands and is also involved in the functioning of the immune system, influencing the production of lymphokines.

Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of a child leads to rickets, in adults - to osteomalacia, pregnant women may experience symptoms of tetany, disruption of the calcification processes of the bones of newborns.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal imbalances.

Compound

Colecalciferol (vitamin D3) + excipients.

Pharmacokinetics

Aquadetrim aqueous solution is absorbed better than an oil solution (this is important when used in premature infants, since in this category of patients there is insufficient production and flow of bile into the intestines, which impairs the absorption of vitamins in the form of oil solutions). After oral administration, colecalciferol is absorbed from the small intestine. Metabolized in the liver and kidneys. Penetrates through the placental barrier. Excreted in breast milk. Colecalciferol accumulates in the body. Excreted by the kidneys in small quantities, most of it is excreted in bile.

Indications

Prevention and treatment:

vitamin D deficiency;
rickets and rickets-like diseases;
hypocalcemic tetany;
osteomalacia;
metabolic osteopathies (hypoparathyroidism and pseudohypoparathyroidism);
osteoporosis, incl. postmenopausal (as part of complex therapy).

Release forms

Drops for oral administration 10 ml (aqueous solution).

Instructions for use and dosage

The dose is set individually, taking into account the amount of vitamin D that the patient receives as part of the diet and in the form of medications.

The drug is taken in 1 spoon of liquid (1 drop contains 500 IU of colecalciferol).

For the purpose of prevention for full-term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient exposure to fresh air, the drug is prescribed at a dose of 500-1000 IU (1-2 drops) per day.

Premature babies from 4 weeks of life, twins and children living in unfavorable conditions are prescribed 1000-1500 IU (2-3 drops) per day.

In the summer, the dose can be reduced to 500 IU (1 drop) per day.

Pregnant women are prescribed 500 IU (1 drop) per day throughout pregnancy, or 1000 IU per day, starting from the 28th week of pregnancy.

In the postmenopausal period, 500-1000 IU (1-2 drops) per day are prescribed.

For the treatment of rickets, the drug is prescribed daily at a dose of 2000-5000 IU (4-10 drops) per day for 4-6 weeks, depending on the severity of rickets (1, 2 or 3) and the course of the disease. In this case, the patient’s clinical condition and biochemical parameters (calcium, phosphorus levels, alkaline phosphatase activity in the blood and urine) should be monitored. The initial dose is 2000 IU per day for 3-5 days, then, if well tolerated, the dose is increased to an individual therapeutic dose (usually up to 3000 IU per day). A dose of 5000 IU per day is prescribed only for pronounced bone changes. If necessary, after a 1 week break, the course of treatment can be repeated.

Treatment should be continued until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500-1500 IU per day.

When treating rickets-like diseases, 20,000-30,000 IU (40-60 drops) per day is prescribed, depending on age, body weight and severity of the disease, under the control of biochemical blood parameters and urine analysis. The course of treatment is 4-6 weeks.

When treating postmenopausal osteoporosis (as part of complex therapy), 500-1000 IU (1-2 drops) per day is prescribed.

Side effect

loss of appetite;
nausea, vomiting;
headaches, muscle and joint pain;
constipation;
dry mouth;
polyuria;
weakness;
mental disorders, incl. depression;
weight loss;
sleep disturbance;
temperature increase;
protein, leukocytes, hyaline casts appear in the urine;
increased calcium levels in the blood and its excretion in the urine;
possible calcification of the kidneys, blood vessels, lungs;
hypersensitivity reactions.

Contraindications

hypervitaminosis D;
hypercalcemia;
hypercalciuria;
urolithiasis (formation of calcium oxalate stones in the kidneys);
sarcoidosis;
acute and chronic kidney diseases;
renal failure;
active form of pulmonary tuberculosis;
children up to 4 weeks of age;
hypersensitivity to vitamin D3 and other components of the drug (especially benzyl alcohol).

Use during pregnancy and breastfeeding

During pregnancy, Aquadetrim should not be used in high doses due to the possibility of teratogenic effects in case of overdose.

Aquadetrim should be prescribed with caution during lactation, because When using the drug in high doses, a nursing mother may develop overdose symptoms in the child.

During pregnancy and breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day.

Use in children

Contraindicated in children under 4 weeks of age.

special instructions

When prescribing the drug, it is necessary to take into account all possible sources of vitamin D.

The use of the drug for medicinal purposes in children must be carried out under close medical supervision and the dosage regimen must be adjusted during periodic examinations, especially in the first months of life.

Long-term use of Aquadetrim in high doses or use of the drug in loading doses can lead to chronic hypervitaminosis D3.

Aquadetrim and calcium in high doses should not be used simultaneously.

Control of laboratory parameters

When using the drug for medicinal purposes, it is necessary to monitor the level of calcium in the blood and urine.

Drug interactions

With simultaneous use of Aquadetrim with antiepileptic drugs, rifampicin, cholestyramine, the absorption of colecalciferol is reduced.

With simultaneous use of Aquadetrim and thiazide diuretics, the risk of developing hypercalcemia increases.

The simultaneous use of Aquadetrim with cardiac glycosides may enhance their toxic effect (increases the risk of developing cardiac arrhythmias).

Analogues of the drug Aquadetrim

Structural analogues of the active substance:

Vigantol;
Videohol;
Videhol solution in oil;
Vitamin D3;
Vitamin D3 100 SD/S dry;
Vitamin D3 Bon;
Vitamin D3 aqueous solution;
Cholecalciferol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Girls, many times over the past three months I have come across questions in posts about how to use this vitamin! Don't be offended, dear mothers, but many things surprise you: when you buy a drug, do you not read the instructions? Or does your doctor not explain to you how to take it correctly? It was especially funny to read when several mothers desperately argued that this was already an aqueous solution and did not need to be dissolved additionally in water!!! Dear mothers, these are instructions for using this vitamin, for those who are interested, you can save it, it will come in handy!!! (the main points are in bold, for those who are too lazy to read). Just don’t need to prove that you are so smart, you are dripping directly into your mouth, and wrote the instructions for fools! I wish everyone health and good luck!!!

Pharmachologic effect:

The active ingredient of the drug is colecalciferol (vitamin D3) – a regulator of calcium and phosphate metabolism. Synthetic colecalciferol is identical to the endogenous one, which is formed in the body under the influence of sunlight. Colecalciferol has more pronounced physiological activity compared to ergocalciferol (vitamin D2). Under the influence of the drug, the metabolism of calcium and phosphates in the human body is normalized. This contributes to the proper formation of the bone skeleton and the preservation of bone tissue structure. The drug has a pronounced antirachitic effect. Colecalciferol promotes more intense adsorption of calcium and phosphate in the distal small intestine, by increasing the permeability of cellular and mitochondrial membranes of the intestinal epithelium. Promotes the passage of divalent ions, including calcium, through membranes. Improves the reabsorption of phosphates during glomerular filtration. Facilitates the uptake of calcium and phosphates into bone tissue, regulates the distribution of these ions in the blood plasma, soft tissues and bones.

In addition, without colecalciferol, the full functioning of the parathyroid glands is impossible. By influencing the production of lymphokines, the drug participates in the formation of nonspecific immunity. Colecalciferol takes part in the synthesis of adenosine triphosphoric acid.
Normalization of the content of calcium ions in the blood leads to the maintenance of normal skeletal muscle tone and regulates heart function. Vitamin D3 facilitates the conduction of nerve impulses and affects blood clotting.
With hypovitaminosis D and calcium deficiency, diseases such as rickets and osteoporosis can develop. Young children during periods of intensive growth and postmenopausal women are especially susceptible to them, which is due to hormonal changes in the body. Pregnant women with a lack of colecalciferol experience symptoms of tetany.
Aquadetrim, an aqueous solution of colecalciferol, is better adsorbed and has greater bioavailability compared to oil solutions. In addition, the aqueous solution does not require the presence of bile for absorption into the blood, which is an important factor for premature babies with an immature digestive system.

Adsorbed in the distal small intestine, metabolized in the liver and kidneys, excreted by the kidneys and partially with bile. After the release of colecalciferol into the bile, it can be re-absorbed by the intestines or excreted in the feces. Able to accumulate in the body. The drug penetrates well through the placental barrier and is excreted in breast milk.
The half-life is 3-5 days and increases with insufficient renal function.

Indications for use:
Hypo- and vitamin deficiency D.
Prevention and treatment of rickets and rickets-like diseases.
Osteopathies caused by metabolic disorders, including hypoparathyroidism and pseudohypoparathyroidism.
Hypocalcemia.
Tetany caused by hypocalcemia.
Osteomalacia of various etiologies.
To accelerate the healing and restoration of bones after fractures.
Loss of calcium in bones and teeth.
Osteoporosis, including those associated with hormonal changes during menopause and postmenopause.
Spasmophilia.

Mode of application:
The drug is taken orally, dissolved in a small amount of liquid (usually a dose of the drug is dissolved in a tablespoon of water).
1 drop of the drug contains approximately 500 IU of colecalciferol.
Doses are selected by the attending physician individually for each patient, taking into account many factors, including the amount of colecalciferol entering the body with food.

Average doses of Aquadetrim are:
Taking the drug for prophylactic purposes:
Children born after 37 weeks of gestation, starting from 4 weeks of life, are prescribed 500 IU per day.
Children born before the 37th week of gestation, twins, and children living in unfavorable conditions are prescribed 1000-1500 IU (2-3 drops) per day, starting from 3-4 weeks of life. In the summer, with sufficient exposure to fresh air, the dose can be reduced to 500 IU per day.
Pregnant women, starting from the 28th week of pregnancy, are prescribed 500 IU per day.
During menopause and postmenopause, 500-1000 IU per day is prescribed.

Taking the drug for the purpose of therapy:
When treating rickets, the daily dose is 2000-5000 IU, with 2000 IU initially prescribed for 5 days; if the drug is well tolerated, the dose is increased to the required therapeutic dose. Colecalciferol at a dose of 5000 IU per day is prescribed only if the patient has severe bone pathologies. The course of treatment is up to 6 weeks, if necessary, the course is repeated after 1-2 weeks until a stable therapeutic effect is achieved, after which a maintenance dose of 500 IU per day is taken.
For rickets-like diseases, 20,000-30,000 IU (40-60 drops) per day is prescribed, depending on age, weight, severity of the disease, with constant laboratory and medical supervision. The course of treatment is 4-6 weeks.
Aquadetrim in the complex therapy of osteoporosis in the postmenstrual period is used in a daily dose of 500-1000 IU.

Side effects:
Side effects when taking recommended doses of the drug are extremely rare. However, with individual hypersensitivity and/or increasing the dose, the following side effects may develop:

From the central nervous system: headache, mental disorders, depression, stupor, sudden changes in mood, irritability.
From the gastrointestinal tract: nausea, vomiting, stool disorders, weight loss, anorexia, thirst, dry mouth.
From the cardiovascular system: disturbances of the heart, in particular arrhythmias, increased heart rate, increased blood pressure.
From the urinary system: polyuria, formation of kidney stones, nephropathy.
From the musculoskeletal system: myalgia, arthralgia, general muscle weakness.
Others: exacerbation of pulmonary tuberculosis, soft tissue calcification.
The frequency and severity of side effects increase as the drug is taken, due to its accumulation in the body.

Contraindications:
Increased individual sensitivity to colecalciferol, including a history. Individual intolerance to benzyl alcohol.
Increased levels of calcium in the blood (hypercalcemia).
Increased levels of calcium in the urine (hypercalciuria).
Hypervitaminosis D.
Urolithiasis with calcium oxalate deposition.
Insufficiency of kidney function.
Active form of pulmonary tuberculosis.
Large doses of the drug are contraindicated during prolonged immobilization.
The drug should be prescribed with caution during pregnancy and lactation.
In patients with atherosclerosis, sarcoidosis, hyperphosphatemia, acute and chronic kidney and liver diseases. For disorders of the gastrointestinal tract, in particular for gastric and duodenal ulcers. For organic heart lesions, such as pericarditis, myocarditis, etc.

Pregnancy:
The use of the drug is possible after consultation with your doctor. Pregnant women are not prescribed the drug in high doses, as this can lead to impaired fetal development. The teratogenic effect of Aquadetrim can occur with an overdose of the drug. When a pregnant woman takes high doses, the fetus experiences increased sensitivity to vitamin D, suppression of parathyroid function, specific elf-like appearance syndrome, aortic stenosis, and mental retardation. It is not recommended to take the drug in a dose exceeding 500 IU per day.
During breastfeeding, it is necessary to take the drug with caution, since when the mother takes a large dose of the drug Aquadetrim, symptoms of hypercalcemia in the child are possible.

Interaction with other drugs:
Simultaneous use with antiepileptic drugs, neomycin, rifampicin, liquid paraffin, cholestyramine reduces the reabsorption of the drug Aquadetrim.
Thiazide diuretics increase the risk of hypercalcemia and side effects of colecalciferol.
The drug can enhance the toxic effects of cardiac glycosides and increases the likelihood of developing complications from the cardiovascular system.
Tocopherol, vitamin A, pantothenic acid, ascorbic acid, riboflavin reduce the risk of developing side effects of Aquadetrim and reduce its toxicity.
The break between taking Aquadetrim and sodium fluoride should be at least 2 hours. Between taking Aquadetrim and oral tetracyclines - at least 3 hours.
Concomitant use with vitamin D analogues increases the risk of developing hypercalcemia.
Barbiturates, when taken simultaneously with colecalciferol, increase the rate of its biotransformation, which can lead to an increased need for colecalciferol.

Overdose:
When taking the recommended doses of the drug, an overdose is unlikely and is possible only in persons with increased individual sensitivity to colecalciferol. Overdose is manifested by symptoms characteristic of hypercalcemia - arrhythmias, nausea, vomiting, pain in the epigastric region, headache, sudden changes in mood, weight loss, formation of kidney stones, increased urination, thirst, nephrocalcinosis and soft tissue calcification. Arterial hypertension, renal failure, stool disorders, anorexia.

If you take the drug for too long or regularly take excessive doses, chronic colecalciferol poisoning may develop, which is characterized by demineralization of bones, instead of calcium deposition in soft tissues, including the kidneys, lungs, heart, blood vessels, and intestines. As a result of such mineral redistribution, organ functions are disrupted, which can lead to severe dysfunction of internal organs and, as a consequence, death.
To treat overdose conditions, corticosteroids, magnesium, potassium, retinol, thiamine, and ascorbic acid preparations are used. It is also necessary to stop taking the drug Aquadetrim.

Release form:
Solution for oral use, 10 ml in dark glass bottles, 1 bottle in a cardboard package.