Vitamin E in liquid form. External use of vitamin E

Tocopherol is a vital substance for the human body, which is responsible for many important functions. For example, it is involved in maintaining cell youth, maintains general tone, and has an antioxidant effect, neutralizing free radicals. Deficiency leads to many negative changes, such as a drop in immunity, interruptions in the work of the reproductive organs in both men and women. In the male, sexual impotence may occur, in the female - the absence of ovulation, the cessation of menstruation and infertility. Vitamin E in oil is one of the forms of release of a useful element, the intake of which, according to the instructions for use, will help to fill the deficiency of the substance and prevent the development of undesirable consequences. An oil solution containing a biologically active substance is dispensed from a pharmacy without a doctor's prescription. But, despite this, it is advisable to consult a specialist before taking the drug. Only he can determine the correct dosage and duration of treatment.

pharmaceutical companies produced with synthetic , ampoules, in the form of an oily solution, intended for oral administration. As auxiliary components, vegetable oil , most often refined sunflower, non-deodorized or deodorized. Myself vitamin E belongs to the group . It has no smell, color - light yellow with an admixture of green.

Once in the human body, the substance has a positive effect on the work of the muscular and nervous systems, and also starts some metabolic processes.

Pharmacological properties

According to the instructions for use, vitamin E oil is absorbed into the bloodstream at the level of the duodenum. Absorption occurs in the presence of bile acids, salts and fats, as well as pancreatic enzymes - without their participation, the full absorption of tocopherol is impossible. On average, about 50-70% of the incoming volume is absorbed, which depends on the individual characteristics of the state of the human body.

After entering the bloodstream, the vitamin is captured by lipoproteins contained in the blood plasma, and together with them it spreads throughout the body. In the event that there are violations in protein metabolism, the distribution of tocopherol does not occur. The maximum concentration of the element is reached 4 hours after taking the oil solution. During pregnancy, at least 20% of the element passes into the bloodstream of the fetus, and during breastfeeding, a part leaves the mother's body along with breast milk.

The processing of a biologically active substance occurs in the liver to active components, after which the remains are excreted from the body with urine through the kidneys and through the intestines along with bile. Active components are absorbed back and circulate further through the body, performing their functions. Complete elimination of tocopherol from the human body takes a long time, in newborns this process is even longer.

The effect of vitamin E on the body

After ingestion, the oil solution has various actions:

Increases the elasticity of the vascular wall.
Prevents the development of dystrophic processes in muscle tissue (including in the heart muscle).
Prevents the occurrence of oxidative reactions ahead of time.
Supports the maturation and release of the egg, increasing the chance of conception.
important in that it participates in the process of seminal fluid synthesis, stimulating the growth and development of spermatozoa.
Increases libido in both men and women.
Participates in the synthesis of hemoglobin and red blood cells, contributing to plasma renewal.

When are vitamins prescribed?

According to the instructions, an oil solution of tocopherol is prescribed for vitamin deficiency or in case of an increased need for it in the following cases:

Prematurity.
Diseases of the peripheral nervous system.
Myopathies, including necrotizing.
Obstructive jaundice.
Cirrhosis of the liver.
Pregnancy planning and first trimester of gestation.
Malabsorption syndrome.
celiac disease
Atresia of the biliary tract.
Chronic congestion of bile.
Crohn's disease.
parenteral nutrition.
Treatment of drug addiction and nicotine addiction.
breastfeeding period.
Prevention of hemolytic anemia and newborns .

Admission Restrictions

Vitamin E in oil and any other dosage forms is not recommended for the following conditions:

Hypersensitivity of the body to vitamin E and other components that make up the product.
A history of stroke and myocardial infarction.
Pathologies of the blood coagulation system.
High risk of thromboembolism.
Sclerosis of the coronary vessels.

Mode of application

Before you start taking an oil solution, it is important to consult a specialist and carefully read the instructions.

An oily solution of tocopherol is available in different concentrations of the active substance - 50, 100 and 300 mg / ml. 1 drop of the drug in the first case contains 1 mg of vitamin E, in the second - 2 mg, in the third - 6 mg.

The dosage of vitamin E in oil varies depending on the purpose of taking the synthetic drug:

To prevent tocopherol deficiency apply a 5% solution at a dosage of 10 mg per day.
Treatment of identified deficiency - 10-50 mg per day.
Treatment of pathologies of the central nervous system and muscle tissue - 50-100 mg per day. The average course of treatment is 1.5 months.
Therapy for male infertility - 150-300 mg in combination with hormonal drugs.
Threatened miscarriage or premature birth - 100-150 mg.
Increased risk of fetal abnormalities - 100-150 mg.
Treatment of skin pathologies - 70-100 mg.
Vascular pathologies - 100 mg in combination with retinol.
Underweight in premature babies - 5-10 mg per day.

The maximum daily dose of vitamin E is 300 mg per day. If it is exceeded, the development of symptoms is possible - nausea, vomiting, general weakness, weakening of vision, asthenia, attacks of dizziness.

With prolonged use of high doses, serious disorders can occur - bleeding, a drop in libido, impaired potency, thrombophlebitis, changes in the level of thyroid hormones.

External use of vitamin E

An oil solution with tocopherol is used and - it actively affects the skin, nails and hair, renewing their cells and maintaining a healthy and young look.

Prevents the appearance of age-related changes.
Helps to get rid of freckles and age spots.
Soothes and heals wounds.
Protects against the action of free radicals.
Maintains moisture balance and softens the skin.

In the fight against acne, tocopherol can also provide support - removing toxins from the body, it helps the sebaceous glands of the skin to free themselves from blockages. In addition, the vitamin reduces inflammation and increases the body's ability to fight infection.

Oil solution for external use can be used in various ways: just apply to problem areas, add a few drops to creams and face masks.

The benefit is undeniable - when it hits the scalp, it nourishes it, stimulates blood flow, thereby accelerating the growth of hairline, prevents brittleness and excessive loss. In addition, the vitamin promotes cell regeneration, heals wounds and regulates the production of sebum. The oil solution can be added a few drops to a factory-made or home-made shampoo or mask.

For nails, tocopherol is used in the form of baths or masks. It helps to prevent brittleness, lamination, improves the appearance of the nail and helps to restore the plate after certain diseases. The easiest way to apply the oil is to simply rub a drop into the surface of the nail and the surrounding skin.

Vitamin E oil solution is easy to use and easy to dose. When taken correctly, the effect occurs quickly enough, and side effects rarely develop. An important condition is the correct dosage and duration of treatment.

Translated from Latin, the name of vitamin E (aka tocopherol) is translated as "promoting birth." And this name is fully justified - indeed, women and men often use drug complexes based on it to restore fertility (childbearing) ability.

But, in addition to favoring the birth of a new life, this vitamin also has a lot of valuable properties for female beauty.

The fair sex, who regularly eat food with its content, remain young and beautiful much longer than their peers, who do not attach special importance to proper fortified nutrition.

And if you use a solution of tocopherol externally, purely for cosmetic purposes, you can achieve visible rejuvenation in the shortest possible time.

Most often, vitamin E is used by women in the preparation of nourishing and regenerating face masks. These masks are prepared independently, at home, and their recipes are not difficult. Usually they include products that are available in the house of each of you. With the regular use of such skin care products, you are guaranteed to look like a queen.

So, how to properly use vitamin E for face masks, and what is its beneficial effect?

Tocopherol: how is it useful for facial skin?

For external use of vitamin E, an oil solution is sold in pharmacies and large pharmaceutical chains. Providing competent care for the skin of the face with it is simple and pleasant. Busy women who lack free time simply apply it to cleansed skin in the evening, using it purely as a night cream.

If you have a free hour during the day, we advise you to try masks based on this solution. Since their ingredients interact with each other, complementing each other, the effect is achieved even faster, and is much more pronounced.

Let's see why vitamin E is so useful for the dermis and epidermis?

The role of tocopherol for facial skin is extremely important and is not exaggerated at all. The first and main effect that this vitamin provides to it is firming and increasing elasticity. Without sufficient intake of this nutrient in the body, the skin begins to age rapidly. It becomes flabby, extremely susceptible to the influence of gravitational ptosis, dehydrated and wrinkled.

Even muscle structures cease to be elastic without this important element. Therefore, under the influence of the law of attraction, without proper "recharge" they also start "stretch" to the ground along with the skin. The result is a swollen oval of the face, often prematurely.

To keep your skin in good condition, you must consume enough tocopherol by mouth (Daily Value). It is 100 mg of the substance per day. It can be found in such quantities in food, but if you have any doubts about the quality of modern products that you purchase in the markets or in supermarkets, consult your doctor about taking multivitamin and polymineral complexes.

It should be emphasized here that tocopherol is a fat-soluble vitamin, the resources of which are constantly present in your body.

Therefore, its persistent excess can also adversely affect your health, as well as deficiency. Taking vitamins A and E in its pure form without a prescription is not recommended for anyone.

For facial skin, it will be better if you start using tocopherol topically, externally. You can use it as a mask, mixed with other nourishing ingredients, or you can use it in place of a night cream in its pure form. Don't worry - you won't overfeed your skin even if you use the solution on a daily basis. She will only benefit from this. True, you should not overdo it either - it is important to calculate the course and stick to it initially.

In addition to a mask with concentrated vitamin E, you can enrich your usual care cream with a solution. If you drive a whole ampoule of a vitamin into it, you will have to store the resulting remedy in the refrigerator. It is better to add oil to the original composition of the cream in portions.

What effect can be obtained?

Vitamin E oil solution for the face will provide you with the following actions:

To enhance the effect of tocopherol, you can choose a solution of combined vitamins. For example, women greatly praise the effect of masks with vitamins C and E. Some prefer to use retinol and tocopherol solutions, which most harmoniously complement each other from a biological and chemical point of view.

The best recipes for face masks with the addition of tocopherol

We figured out how beneficial vitamin E is for the skin. But how to use it correctly if you are not going to do it in its pure form? Try a vitamin E mask at home! Its preparation and use will not take you much time and effort, and the result is guaranteed to delight and pleasantly surprise you.

Mask for restoring and nourishing dry skin:

Grind a tablespoon of cottage cheese through a sieve to make the mass soft and pliable;
Add a little warmed sour cream (enough oily) to make the mixture plastic and a little liquid;
Enter into the mass half an ampoule of concentrated vitamin E (or the contents of several capsules of the drug "Aevit");
Apply the resulting composition in a dense layer on the cleansed and steamed surface of the face;
Hold for at least half an hour;
Rinse off the mask with warm water without soap and other cleansers containing aggressive ingredients.

Rejuvenating and nourishing mask:

Moisturizing mask:

Grate some fresh cucumber pulp on a fine grater;
Enter into the mass a tablespoon of an oil solution of vitamins A and E;
Enrich the mixture with biostimulated aloe vera juice (you can use a ready-made pharmacy version);
Apply to a clean, steamed face for twenty minutes;
Wash off with warm water without soap.

You can also use ready-made masks if you have your favorite compositions. Just add a couple of drops of oil (about one teaspoon or coffee spoon) to the usual portion of the care product, then stir directly in your hand and apply to prepared, cleansed skin.

It is very useful to use vitamin for the care of delicate and thin skin of the eyelids. In order not to make it heavier with oil, the solution must be diluted with something. For this purpose, your usual cream or gel to restore the skin around the eyes will come in handy.

oral solution oily 5%, 10% and 30%

Registration number: R N001153/01
Tradename:α-Tocopherol acetate.
International non-proprietary name: alpha-tocopherol acetate
Dosage form: oral solution [oily]
Description
Transparent oily liquid from light yellow to dark yellow without rancid odor. A greenish tint is allowed.
Compound
Active substance: Vitamin E (α-Tocopherol acetate) - 50 g, 100 g and 300 g;
Excipients- sunflower oil (refined deodorized sunflower oil) - up to 1 liter.
Pharmacotherapeutic group: vitamin
ATH CODE:[A11HA03]

Pharmacological properties

Vitamin E is a natural antioxidant. Protects cell membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes - hemoglobin, myoglobin, cytochromes, catalase, peroxidase. It inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits cholesterol synthesis. Prevents hemolysis of erythrocytes, increased permeability and fragility of capillaries, impaired function of seminiferous tubules and testicles, placenta, normalizes reproductive function; prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles.

Indications for use

Hypovitaminosis E; complex therapy of conditions accompanied by an increased need of the body for vitamin E:
with muscular dystrophies, ringworm, amyotrophic lateral sclerosis, asthenic and neurasthenic syndromes, overwork, paresis, myasthenia gravis, myopathies, menstrual irregularities, threatened miscarriage, menopause, dysfunction of the gonads in men and women;
with dermatosis, psoriasis;
with atrophy of the mucous membrane of the respiratory tract, periodontal disease;
in rheumatic diseases: fibrositis, tendinopathy, diseases of the joints and spine;
with endocrine diseases: thyrotoxicosis, diabetes mellitus, especially with ketoacidosis, diabetic polyneuropathy;
with malabsorption syndrome, chronic liver diseases;
with myocardial dystrophy, spasms of peripheral vessels.
In a state of convalescence after diseases that occurred with a febrile syndrome.

Contraindications

Increased individual sensitivity to the drug.
With caution: hypoprothrombinemia (against a background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 IU), severe atherosclerosis of the coronary arteries, myocardial infarction, increased risk of thromboembolism.

Dosage and administration

For oral administration, the drug is prescribed in the following doses:
In diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc.) 50-100 mg per day (50-100 drops of a 5% solution, 25-30 drops of a 10% solution or 7-15 drops of a 30% solution) for 1- 2 months. Repeated courses in 2-3 months.
For men with impaired spermatogenesis and potency, 100-300 mg per day (100-300 drops of a 5% solution, 50-150 drops of a 10% solution or 15-46 drops of a 30% solution) in combination with hormone therapy for a month.
With a threatened abortion, 100-150 mg per day (100-150 drops of a 5% solution, 50-75 drops of a 10% solution or 15-23 drops of a 30% solution).
With habitual abortion and deterioration of intrauterine development of the fetus, 100-150 mg per day (100-150 drops of a 5% solution, 50-75 drops of a 10% solution or 15-23 drops of a 30% solution) in the first 2-3 months of pregnancy daily or after day.
In peripheral vascular diseases, myocardial dystrophy, atherosclerosis, 100 mg per day (100 drops of a 5% solution, 50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. Course duration 20-40 days, after 3-6 months the course of treatment can be repeated.
For skin diseases, from 15 to 100 mg per day (15-100 drops of a 5% solution, 7-50 drops of a 10% solution or 2-5 drops of a 30% solution) for 20-40 days.
1 drop from an eye dropper contains: α - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.

Side effect

Allergic reactions. The use of large doses of the drug can cause dyspeptic disorders, decreased performance, weakness, thrombophlebitis, pulmonary embolism, thrombosis, increased creatine kinase activity, creatinuria, hypercholesterolemia, white hair growth in areas of alopecia with blistering epidermolysis.

Overdose

Symptoms: when taken for a long period at doses of 400-800 IU / day (1 mg = 1.21 IU) - blurred visual perception, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia, when taking more than 800 U / day for a long period - an increase in the risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites.
Treatment: symptomatic, withdrawal of the drug, the appointment of glucocorticosteroid drugs.

Interaction with other drugs

Enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants.
Increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides.
Prescribing vitamin E in high doses can cause vitamin A deficiency in the body.
Increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased).
The simultaneous use of vitamin E at a dose of more than 400 units / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding.
Colestyramine, colestipol, mineral oils reduce absorption.
High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

special instructions

active substance: vitamin E-acetate;

1 ml of the drug contains vitamin E-acetate, in terms of 100% substance - 50 mg or 100 mg, or 300 mg;

excipient: sunflower oil.

Dosage form

Oily oral solution.

Transparent oily liquid from light yellow to dark yellow, without rancid odor. A greenish tint is allowed.

Name and location of the manufacturer

PJSC "Technologist".

20300, Ukraine, Cherkasy region, Uman, st. Manuilsky, 8.

Pharmacotherapeutic group

Other simple vitamin preparations. Tocopherol (vitamin E). ATC code A11H A03.

Vitamin E is an antioxidant agent that protects various endogenous substances of the body from oxidation. It inhibits lipid peroxidation, which is activated in many diseases. It takes part in the processes of tissue respiration, biosynthesis of heme and proteins, metabolism of fats and carbohydrates, cell proliferation, etc. With a deficiency of vitamin E, degenerative changes in the muscles develop, capillary permeability and fragility increase, the epithelium of the seminiferous tubules and testicles is reborn, degenerative processes are noted in the nervous tissue and hepatocytes. Vitamin E deficiency can cause hemolytic jaundice in newborns, malabsorption syndrome, steatorrhea.

The drug is absorbed in the intestine in the presence of fat and bile acids, the mechanism of absorption is passive diffusion. It is transported by blood β-lipoproteins, the maximum content is reached by the 4th hour after ingestion. It is excreted in the feces, conjugates and tocopheronic acid are excreted in the urine.

Indications for use

Treatment of muscular dystrophies of various nature and genesis, articular and tendon-muscular contractures (Dupuytren's contractures), spinal cord lesions (amyotrophic lateral sclerosis), systemic connective tissue diseases (rheumatoid arthritis, dermatomyositis, rheumatism and fibrositis), dysfunction of the male sex glands and the menstrual cycle, threatened miscarriage. For children, tocopherol is used to treat hemolytic jaundice in newborns, increased capillary permeability in infants, malnutrition, rickets, developmental disorders, systemic diseases of the connective tissue (scleroderma, juvenile rheumatoid arthritis), hypochromic anemia. In complex therapy for peripheral vascular lesions, vascular atherosclerosis, myocardial dystrophy, hypertension, allergic and ulcerative skin lesions, psoriasis, endocrine thyroid diseases, diabetes mellitus, periodontal disease, pathologies requiring antioxidant therapy.

Contraindications

Increased individual sensitivity to the components of the drug, severe cardiosclerosis, myocardial infarction.

Appropriate safety precautions for use

With caution prescribed for atherosclerosis, increased risk of thromboembolism. When using the drug, it is necessary to maintain the dosage and duration of the course of treatment, which are prescribed by the doctor, to prevent overdose and the occurrence of hypervitaminosis E.

With prolonged use of high doses of the drug, it is necessary to control the time of blood clotting.

Use during pregnancy or lactation

During pregnancy or lactation, the drug should be used as directed by a doctor.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms

If you experience dizziness, blurred vision, you should refrain from driving vehicles or working with other mechanisms.

Children

The drug is used for children from birth only as directed and under medical supervision.

Dosage and administration

alpha-Tocopherol acetate (Vitamin E) is administered orally.

1 ml of the solution contains 50 mg, 100 mg and 300 mg of vitamin E, respectively (1 ml of the solution contains 30 drops from an eye dropper).

With muscular dystrophies, amyotrophic lateral sclerosis, other diseases of the neuromuscular system, the daily dose is 50-100 mg (15-30 drops of a 10% solution). Accepted for 30-60 days with a repetition of courses in 2-3 months. In case of violation of spermatogenesis and potency in men, the daily dose is 100-300 mg (10-30 drops of a 30% solution). In combination with hormonal therapy, it is prescribed for 30 days.

With the threat of abortion, Alpha-Tocopherol acetate (Vitamin E) is taken in a daily dose of 100-150 mg (10-15 drops of a 30% solution) for 7-14 days. In case of abortion and deterioration of intrauterine development of the fetus, 100-150 mg (10-15 drops of a 30% solution) are prescribed daily or every other day in the first 2-3 months of pregnancy.

With atherosclerosis, myocardial dystrophy, peripheral vascular diseases, 100 mg (30 drops of a 10 5 solution or 10 drops of a 30% solution) of the drug are taken together with vitamin A per day. The course of treatment is 20-40 days with a possible repetition of treatment after 3-6 months.

In the complex therapy of cardiovascular diseases, eye and other diseases, Alpha-Tocopherol acetate (Vitamin E) is prescribed at a dose of 50-100 mg (15-30 drops of a 10% solution or 5-10 drops of a 30% solution). The course of treatment is 1-3 weeks.

In dermatological diseases, the daily dose of the drug is 50-100 mg (30-60 drops of a 5% solution or 15-30 drops of a 10% solution, or 5-10 drops of a 30% solution). The course of treatment is 20-40 days.

With malnutrition and a decrease in capillary resistance in newborns, a daily dose of 5-10 mg (3-6 drops of a 5% solution) is used. The course is determined individually.

Overdose

When using the recommended doses, undesirable reactions do not appear. When taking high doses of the drug (more than 400 mg per day for a long time), dyspeptic disorders, feeling of fatigue, general weakness, headache are possible; creatinuria, increased activity of creatine kinase, increased concentrations of cholesterol, triglycerides, a decrease in the concentration of thyroxine and triiodothyronine in the blood serum, an increase in the content of estrogen and androgens in the urine.

There is no specific antidote. Treatment is symptomatic.

Side effects

Allergic reactions (including itching, skin flushing). With prolonged use of high doses of vitamin E, there may be a decrease in blood coagulation, bleeding of the gastrointestinal tract, liver enlargement, creatinuria, a feeling of fatigue, weakness, headache, nausea, dizziness, blurred vision.

Interaction with other medicinal products and other forms of interaction

Vitamin E can not be used orally together with iron, silver preparations, alkaline-reactive agents, indirect anticoagulants.

Vitamin E facilitates the absorption and assimilation of retinol, preventing the development of beriberi A.

Vitamin E and its metabolites reveal an antagonistic effect on vitamin K. Vitamin E enhances the effect of steroidal and non-steroidal anti-inflammatory drugs (sodium diclofenac, ibuprofen, prednisolone, etc.); reduces the toxic effect of cardiac glycosides (digitoxin, digoxin, etc.), vitamin A and D.

Vitamin E may increase the effectiveness of anticonvulsants in patients with epilepsy, in the blood of which there is an increased concentration of lipid peroxidation products.

Cholestyramine, colestipol, mineral oils reduce the absorption of vitamin E.

Best before date

Storage conditions

Store in original packaging at a temperature not exceeding 25 ºС.

Keep out of the reach of children.

- α-tocopherol acetate (tocopherol)

Composition and form of release of the drug

10 ml - dark glass bottles (1) - packs of cardboard.
10 ml - dark glass dropper bottles (1) - packs of cardboard.
15 ml - dark glass bottles (1) - packs of cardboard.
15 ml - dark glass dropper bottles (1) - packs of cardboard.
20 ml - dark glass bottles (1) - packs of cardboard.
20 ml - dark glass dropper bottles (1) - packs of cardboard.
25 ml - dark glass bottles (1) - packs of cardboard.
25 ml - dark glass dropper bottles (1) - packs of cardboard.
30 ml - dark glass bottles (1) - packs of cardboard.
30 ml - dark glass dropper bottles (1) - packs of cardboard.
50 ml - dark glass bottles (1) - packs of cardboard.
50 ml - dark glass dropper bottles (1) - packs of cardboard.

pharmachologic effect

It has an antioxidant effect, participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, and other important processes of tissue metabolism, prevents hemolysis of erythrocytes, and prevents increased permeability and fragility of capillaries.

Pharmacokinetics

When taken orally, absorption is 50%; in the process of absorption, it forms a complex with lipoproteins (intracellular carriers of tocopherol). Bile acids are required for absorption. It binds to alpha 1 and beta lipoproteins, partially to serum. If protein metabolism is disturbed, transport is hindered. Cmax is reached after 4 hours. It is deposited in the adrenal glands, pituitary gland, testes, adipose and muscle tissue, erythrocytes, and liver. More than 90% is excreted in the bile, 6% - by the kidneys.

Indications

Hypovitaminosis, conditions of convalescence after diseases occurring with a febrile syndrome, high physical activity, old age, diseases of the ligamentous apparatus and muscles. Climacteric vegetative disorders. with overwork, asthenic neurasthenic syndrome, primary muscular dystrophy, post-traumatic, post-infectious secondary myopathy. Degenerative and proliferative changes in the joints and ligaments of the spine and large joints.

Contraindications

Hypersensitivity to tocopherol.

Dosage

Usually prescribed 100-300 mg / day. If necessary, the dose can be increased to 1 g / day.

Side effects

Maybe: allergic reactions; when taken in high doses -