"Biseptol": instructions for use of suspension and tablets for children with dosage calculation. Biseptol - a modern take on a long-familiar antibacterial drug

Medicines designed to suppress vital processes and destroy pathogenic microorganisms are called antibiotics. The translation of this term from Latin – “against life” – leaves no doubt.

However, recently there has been some confusion with the classification of individual drugs used to treat microbial infections. Often, drugs related to sulfonamides or nitrofurans are simply called “antimicrobial”. The above article provides a detailed and reasoned answer to a common question regarding a popular medicine.

Biseptol ® antibiotic or not?

Opinions in various sources on this matter are diametrically opposed, however, the correct answer is “yes”.

According to the modern classification, Biseptol ® is an antibiotic that belongs to a separate group of sulfonamides and exhibits antimicrobial activity against a very wide range of pathogenic bacteria (gram-negative, gram-positive and atypical).

By the way, our website offers a free service for checking whether any drug is an antibiotic. To use it, click on the gear icon stuck on the right side of the screen:

Biseptol ® acts bacteriostatically, that is, it inhibits the reproduction and growth of microorganisms. This happens due to the introduction of the active substance (co-trimoxazole) into the cell and blocking the synthesis of vitamin B9 - folic acid.

Like other antibiotics, this medicine only fights bacteria and is inactive against viruses. The broader concept of “antibacterial drug” directly indicates that using it to treat influenza or ARVI is pointless and even dangerous.

However, as statistical studies show, about half of the Russians surveyed mistakenly believe that antibiotic therapy is an adequate treatment for diseases of a viral nature and independently “prescribe” pills for themselves. The result of such illiteracy is the emergence of many resistant strains, severe complications and the development of superinfections that are difficult to treat (often fatal).

Why is Biseptol ® classified as an antibiotic?

Thus, in all respects, Biseptol fully corresponds to the concept of “antibiotic”. Then where does the information come from that it is not such and does not give characteristic side effects (that is, less harmful to the body)? To answer this question, you should briefly familiarize yourself with some historical information, the principles of manufacturing antimicrobial drugs and the characteristics of the drug itself.

A little history

Biseptol belongs to the group of sulfonamide antibiotics - synthetic antimicrobial drugs, the history of whose discovery is quite interesting.

The first of them was synthesized long before penicillin (in 1908) and was named Sulfanilamide ®.

It is noteworthy that this compound was initially considered an industrial dye, and the chemotherapeutic properties of its component - prontosil (or red streptocide) - were discovered later, in 1934. A year later it was found that only the sulfonamide group formed as a result of metabolism ("white streptocide”, without dye), which is still used in medicine today.

As a result of numerous experiments and studies over the past years, various drugs based on sulfonamide ® and its derivatives have been obtained. The modification led to an expansion of the spectrum of antimicrobial activity and overcoming the resistance of pathogens (most of them are currently resistant to the first generation of drugs). Thus, Biseptol ® is a combination of sulfamethoxazole with trimethoprim (co-trimoxazole ®), in which the components act synergistically, preventing the synthesis and absorption of folic acid necessary for cell development.

Indications and release form

Information about its antimicrobial activity will help you answer the question affirmatively about whether Biseptol ® is an antibiotic or not:

• effective against staphylococci and streptococci (gram-positive flora);
• Of the gram-negative pathogens, E. coli, Vibrio cholerae, salmonella and many others are sensitive to it.

Not active against treponema, mycoplasma, mycobacteria, Pseudomonas aeruginosa.

Thus, this drug exhibits antibacterial properties characteristic of antibiotics and is successfully used to treat infectious inflammation of the digestive, respiratory, genitourinary, skin, muscles, and subcutaneous tissue.

The original drug is produced by the Polish concern Medana Pharma in the form of tablets (dosage of co-trimoxazole 120 and 480 mg), suspension for oral administration, concentrate for the production of infusion and injection solutions.

This range of dosage forms allows you to accurately calculate the required amount of the active substance and create an optimal treatment regimen for a patient of any age. Self-medication (especially in relation to children) is strictly forbidden. In addition, it is necessary to strictly and strictly adhere to medical prescriptions and not interrupt treatment earlier than after 5 days, if there are no negative reactions from the body.

Application, side effects and contraindications

Due to the peculiarities of absorption and excretion from the body, it is usually prescribed twice a day. You should take the tablets after meals with a sufficient amount of boiled or filtered water (at least a glass). A single dose for an adult and a child over twelve years of age ranges from 240 to 960 mg, depending on the nature and severity of the specific disease. The amount of active substance required for younger children is calculated according to weight.

Biseptol ® has a number of strict contraindications and side effects. The latter do not occur often; disorders of the gastrointestinal tract (diarrhea, abdominal pain, nausea or vomiting) and central nervous system (headache, insomnia) are mainly observed. Less common are allergic reactions in the form of a rash, as well as dysfunction of the kidneys and liver (hematuria, hepatitis). All negative consequences disappear immediately after discontinuation of drug treatment with sulfonamides.

• pregnant women at any stage, since the placental barrier practically does not interfere with the absorption of co-trimoxazole ®, and the teratogenic effect manifests itself in the form of heart defects in the fetus;
• breastfeeding (you should temporarily stop breastfeeding and express milk so that lactation does not stop);
• those suffering from diseases of the liver, kidneys, as well as the cardiovascular and hematopoietic systems;
• children under three years of age (tablet form). However, Biseptol in the form of a suspension or solution can be used from the third month of life.

In addition to the strict prohibitions listed above, a number of restrictions are imposed on the use of the drug. Caution is required if the patient is diagnosed with thyroid disease, asthma, or vitamin B9 deficiency. In addition, if the duration of the course of antibiotic therapy exceeds the minimum period of 5 days, it is necessary to monitor blood counts and, possibly, additionally take folic acid supplements.

Where does false information come from?

As you know, the progenitor of all modern penicillins and the symbol of the beginning of a new era in medicine was benzylpenicillin, secreted by the fungus Penicillium notatum. For centuries, the bactericidal and bacteriostatic effects of mold fungi products have been used purely intuitively (for example, applying moldy bread to wounds in Ancient Egypt). Scientific justification for such methods was given only at the beginning of the last century, when Alexander Fleming made his revolutionary discovery.

Having learned about the ability of some microorganisms to destroy others, scientists around the world began to study the properties of various bacteria and fungi. For example, in 1952, research on the actinomycete Streptomyces erythreus led to the production of the first macrolide (erythromycin), and two years earlier, the polyene fungicide nystatin was isolated from the soil bacterium Streptomyces nourse, which today is of great importance in the treatment of candidiasis. As a rule, the waste products of microorganisms were purified and stabilized, and then put into mass production (hence the corresponding name in the classification - natural).

Later, experiments began to be carried out to change the chemical structure of already known compounds. This was caused not only by the curiosity of researchers, but also by vital necessity: pathogens began to mutate and form resistance to drugs. As a result, new generations of antibacterial agents with a wider spectrum of action and specific mechanisms for overcoming protection, called semi-synthetic, have emerged.

For example, the widespread Staphylococcus aureus (strains of which cause persistent nosocomial infections) produces beta-lactamase, which destroys penicillin. The addition of a beta-lactam ring to the chemical formula made it possible to make more stable drugs (oxacillin ® and other derivatives). To date, all original antibiotics have undergone modifications, since pathogenic microorganisms are constantly changing and adapting.

For a long time, it was the method of preparation that determined whether a drug belonged to antibiotics. Since sulfonamides (like nitrofurans) are completely synthetic substances, until recently the answer to the question of whether Biseptol is an antibiotic was strictly negative.

Already today, established views have been revised, and all drugs that were previously called simply “antimicrobial” were included in the rest of the antimicrobial drugs and included in the classification. And since many authors use old publications and unverified information when compiling popular science articles, there is still a misconception.

The principle of separation by production method is all the more irrelevant, since many modern “natural” drugs (for example,) are obtained exclusively by biosynthesis.

Restoration of microflora

Probiotics

Among sulfonamide drugs, the most popular is Biseptol. This drug is produced in a suspension that can be given to even the smallest children. In addition, Biseptol is available in tablets. Is it allowed to give this dosage form to children and in what dosage is it used?

Biseptol helps with purulent bactericidal infections

Release form

Biseptol tablets are distinguished by their round flat shape, white (sometimes with yellowish) color, as well as the presence of marks and Bs engraving. They are packaged in blisters of 20 pieces and sold 1 blister per pack.

Compound

The substance that provides Biseptol with its therapeutic effect is called co-trimoxazole. This name combines two active compounds, the ratio of which in one tablet is 5 to 1. Depending on the amount of such active ingredients, the drug is presented in two dosages:

1. Tablets 120 mg, which contain 100 mg of sulfamethoxazole, supplemented with 20 mg of trimethoprim.
2. Tablets 480 mg, of which the patient receives sulfamethoxazole in an amount of 400 mg, and trimethoprim in a dose of 80 mg.

To ensure that the drug is hard and the tablet holds its shape, talc, Mg stearate, propyl and methyl parahydroxy benzoate, potato starch, propylene glycol and polyvinyl alcohol are added to the composition.

Different dosages allow you to most accurately determine a single dose for children of different ages

Operating principle

The active substances in Biseptol have a bactericidal effect. They affect the synthesis of proteins in bacterial cells, disrupting it, as a result of which the microbes die. The medication is active against infection with E. coli, enterococci, Klebsiella, salmonella, pneumococcus, Proteus, Shigela, Pneumocystis and many other bacteria. Biseptol is ineffective against pseudomonads, mycobacteria, leptospira, viruses, treponemas and some other microorganisms.

Enterococcus

Klebsiella

Pneumococcus

Indications

Biseptol helps with infections caused by pathogens sensitive to it. It is prescribed for:

• Purulent otitis.
• Sinusitis.
• Typhoid fever.
• Cholera.
• Salmonellosis.
• Brucellosis.
• Bronchitis.
• Bacterial diarrhea.
• Pneumocystosis.
• Typhoid fever.
• Scarlet fever.
• Sore throat.
• Pharyngitis.
• Gonorrhea.
• Whooping cough.
• Laryngitis.
• Pneumonia.
• Bronchiectasis.
• Peritonitis.
• Cholangitis.
• Osteomyelitis.
• Skin abscesses.
• Furunculosis.
• Urethritis.
• Orchitis.
• Cystitis and many other infections.

Dr. Komarovsky dedicated one of his programs to infectious diseases in children:

At what age is it allowed to take it?

Instructions for use of the tablet form of Biseptol include information that the product is recommended for children over three years of age. If you need to prescribe medicine to children who have not yet turned 3 years old, use a suspension. It can be given from 2 months of age.

Contraindications

The use of Biseptol is prohibited:

• If a child is found to be intolerant to this drug or other sulfa drugs.
• If the tests of a small patient showed renal failure.
• If the child’s liver is damaged and its function is severely impaired.
• If a deficiency of glucose 6 phosphate dehydrogenase is detected.
• If a blood test reveals agranulocytosis, aplastic anemia or leukopenia.

Using the drug with caution implies that the child has an allergic disease, thyroid pathology, lack of vitamins B9 and B12, or porphyria.

Side effects

The child's body often reacts to treatment with Biseptol with allergies or disruption of the digestive tract. In addition, the drug may cause:

• Inhibition of hematopoiesis.
• Dizziness, apathy or depression, convulsions, headaches.
• Shortness of breath and cough.
• Renal dysfunction.
• Pain in joints or muscles.

Instructions for use and dosage

The tablets should be taken after meals with plenty of water. The dosage is best determined individually based on the clinical picture, the child’s condition, the sensitivity of the pathogen and other factors. Usually Biseptol tablets are prescribed in the following single dose:

This single dosage of Biseptol should be taken twice a day., and the break between doses should be 12 hours.

The duration of use is determined depending on the pathology. The drug is prescribed for a minimum of 5 days, and when the symptoms of infection disappear, it should be taken for another two days. The average duration of treatment with Biseptol is from 5 to 14 days. If the infection is severe, single dosages may be increased by 30-50%.

Overdose

If you take more tablets than the doctor prescribed, your child will experience headache, nausea, abdominal pain, drowsiness, fever and other negative symptoms. Long-term excess dosage leads to anemia, leukopenia, jaundice and thrombocytopenia.

The amount of drug taken by the child should be closely monitored to avoid overdose.

Interaction with food and other drugs

• Biseptol tablets should not be taken with milk, as this will reduce their effect.
• Before taking the drug, you should not eat foods that are quickly absorbed and excreted from the intestines, such as baked goods or dried fruits.
• During treatment, it is advisable to limit the patient’s diet to fatty foods of animal origin, as well as peas, cabbage, carrots, beans and tomatoes.
• Biseptol enhances the therapeutic effect of the use of indirect anticoagulants, hypoglycemic drugs, phenytoin and methotrexate.
• Co-administration with diuretics will increase the risk of thrombocytopenia.
• The medicine should not be used together with aspirin or drugs that can inhibit hematopoiesis.

Terms of sale

To purchase the tablet form of Biseptol, you must present a prescription from a doctor. The average price of a package of tablets with 120 mg of the active compound is 30 rubles.

Storage conditions and shelf life

Biseptol tablets should be stored away from moisture and sunlight, at temperatures below +25 degrees. Children should not have free access to the drug. The shelf life of this form of medicine is 5 years.

The drug contains a combined active substance Co-Trimoxazole , which in turn consists of substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and (40 mg for suspension and 20 mg (80 mg) for tablets).

Additional funds

For suspension: purified water, macrogol, carmellose sodium, propylene glycol, propyl parahydroxybenzoate, aluminum magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate.

For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

Release form

Available in tablet form, 120 (often called “Children’s Biseptol”) and 480 mg of active substances, in the form of a suspension (syrup).

pharmachologic effect

Bactericidal, antibacterial.

Is Biseptol an antibiotic or not? This product is not an antibiotic.

Pharmacodynamics and pharmacokinetics

Combined antimicrobial drug. The main active ingredient is (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on bacterial metabolism. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid and converts dihydrofolate into tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In combination, the components of the drug Biseptol block the biosynthesis of purines and nucleic acids, without which the reproduction and growth of bacteria is impossible.

The active substances are actively absorbed from the gastrointestinal tract. They are excreted mainly through the kidneys.

What are these tablets and suspension for?

In general, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, epididymitis, lymphogranuloma venereum, chancroid, inguinal granuloma. Let's look at what Biseptol helps with in different parts of the body.

Indications for use of Biseptol for gastrointestinal infections:paratyphoid , typhoid fever , cholangitis, (E. coli), cholangitis, salmonella carriage.

Respiratory tract infections: lobar pneumonia, bronchiectasis, (acute and chronic), Pneumocystis pneumonia, bronchopneumonia .

Infections of soft tissues and skin: furunculosis, wound infections, pyoderma . In complex therapy it is used to treat toxoplasmosis, malaria, South American blastomycosis, and acute brucellosis.

Contraindications

Aplastic anemia, leukopenia, agranulocytosis, B12-deficiency anemia, severe disorders of the renal/hepatic systems, hyperbilirubinemia in children. Biseptol is prescribed with caution for folic acid deficiency and thyroid diseases.

Side effects

Nervous system: dizziness, headaches, rarely depression, aseptic, peripheral neuritis.

Respiratory system: pulmonary infiltrates, bronchospasm.

Digestive system: dyspeptic disorders, cholestasis, diarrhea, vomiting, loss of appetite, glossitis, epigastric pain, increased levels of liver transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis, .

Blood-forming organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.

Side effects from the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with, oliguria, increased urea levels, hematuria, impaired renal function.

Musculoskeletal system: myalgia, arthralgia. , hypoglycemia, .

Instructions for use of Biseptol (Method and dosage)

The dose of the drug in each case is prescribed by the doctor.

Biseptol tablets, instructions for use

Adults: 960 mg once, or 480 mg in 2 doses. Severe infections: 480 mg three times. Course 1-2 weeks.

In acute brucellosis the course of treatment is 3-4 weeks, for paratyphoid and typhoid fever - up to 3 months.

Chronic infections: twice 480 mg tablets.

Instructions for use for children

For children, Biseptol is prescribed twice a day, dose from 120 to 480 mg.

At the age of 3-5 years: 2 times 120 mg per 24 hours.

Biseptol suspension, instructions for use

The syrup is used in the same way as the tablets.

Overdose

Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , fainting, visual impairment, leukopenia, fever, crystalluria . With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, and leukopenia are noted. It is necessary to administer trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg/day. If necessary, hemodialysis is prescribed. There is no specific antidote.

Interaction

Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia increases when taken concomitantly with pyrimethamine (more than 25 mg per week). Thiazides may cause thrombocytopenia. The effectiveness of Biseptol is reduced procainamide , , . The drug leads to the development of cross-allergy when taken simultaneously with oral hypoglycemic drugs. Folic acid deficiency is exacerbated by the administration of barbiturates, phenytoin, . Crystalluria develops when taking , .

Terms of sale

Requires a prescription.

Storage conditions

Keep out of the reach of children at a temperature of no more than 25 degrees Celsius.

Best before date

No more than 3 years.

special instructions

Regular monitoring of the concentration of sulfamethoxazole in the blood is necessary. If the value is more than 150 mcg/ml, then treatment is stopped until the value reaches 120 mcg/ml or lower. If the course of treatment lasts a month or more, then regular monitoring of the blood condition is required. Upon appointment folic acid hematological changes are reversible. In patients with AIDS, side effects are more common and more pronounced. Biseptol is not recommended for use in cases of tonsillitis caused by beta-hemolytic streptococcus gr. A.

Biseptol - an antibiotic or not? According to the annotation, the drug is not an antibiotic.

The recipe in Latin might look something like this: Rp: "Biseptoli-420" D.t.d. No. 20 in tab.

There is no description of the drug on Wikipedia.

Biseptol for children

It is noted that the drug can be used from 3 months of life; naturally, the doses will vary. However, this should be done with caution and only as directed by a doctor. In some countries of the world, Biseptol for children is allowed to be used only from 12 years of age.

Usually, a suspension can be prescribed from 3 months, tablets - from 2 years.

Instructions for Biseptol for children

At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years, take up to 5 ml of Biseptol suspension for children twice a day.

From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years - 10 ml 2 times a day. From 12 years of age, take 20 ml every 12 hours.

How to take pills for children?

At the age of 2-5 years: 2 times 120 mg per 24 hours. From 6 to 12 years, use 480 mg every 12 hours.

The course of treatment is 5-7 days. When using drugs for children, you should drink plenty of water.

Alcohol compatibility

The reaction of combination with alcohol is impossible to predict. The use of these substances together is undesirable.

Biseptol's analogs

Level 4 ATX code matches:

Analogues are the following drugs: Bactiseptol , Biseptazole , Biseptrim , Groseptol , , Oriprim , Raseptol , Soluseptol , Sumetrolim , Triseptol .

Reviews of Biseptol

The product is very effective, especially for respiratory diseases. Has an excellent antibacterial effect. Among the disadvantages, it should be noted that there are sometimes side effects. Should not be used without the direction of the attending physician.

Biseptol for children, reviews

It is considered a very effective means of combating microbes. There are generally no negative reviews when treating children with Biseptol syrup.

Reviews of Biseptol for cystitis

The drug is effective against cystitis, but do not forget about the side effects.

For sore throat

Prescribed when it is impossible to take antibiotics. According to research, microorganisms that cause sore throat have begun to lose sensitivity to this drug.

Biseptol price

The price of Biseptol in 120 mg tablets is 35 rubles for 20 pieces. You can buy 480 mg tablets for 100 rubles per pack of 28 pieces.

The price of Biseptol syrup is approximately 130 rubles.

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Biseptol suspension 240 mg/5 ml 80 ml Medana Pharma S.A.

Biseptol tablets 120 mg 20 pcs.Pabianice Pharmaceutical Works Polfa

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Biseptol 120 tablets 120 mg No. 20

Biseptol 480 tablets 480 mg No. 28

Biseptol suspension (vial 240mg/5ml 80ml)

The drug "Biseptol" is a combined drug with antibacterial properties. It is produced by the Polish pharmaceutical company Polfa and is sold from pharmacies only with a doctor's prescription.

Its active components perfectly fight the proliferation of bacteria, destroy gram-negative and gram-positive microorganisms, including those that have developed resistance to other drugs of the sulfonamide group. In this article we will tell you everything about the drug "Biseptol": what it helps with, what are its indications and contraindications for use. We will also describe how and in what doses it should be used, and what side effects it can have on the human body. We hope you find this information useful.

Release form of the drug "Biseptol"

This medicine is produced in several versions: in the form of tablets of 120 mg and 480 mg, oral suspension of 80 ml and ampoules with concentrate of 8 ml. Regardless of the release form, the drug contains two main components: sulfamethoxazole and trimethoprim (400 mg and 80 mg, respectively). The suspension is prescribed for children and has a pleasant sweetish taste. In addition to the active ingredients, it consists of cremophor RH 40, sodium salt of carboxymethylcellulose, magnesium-aluminum silicate, citric acid, sodium hydrogen phosphate, maltitol, propylhydroxybenzoate, methylhydroxybenzoate, propylene glycol, purified water. Ampoules are used only for inpatient treatment. They, like the suspension, contain, in addition to the two main active ingredients, several auxiliary components: propylene glycol, sodium hydroxide, benzyl alcohol, ethanol, and water for injection. The tablets have a round flat shape, white-yellowish color and engraving “Bs”. In addition to the active ingredients, they consist of potato starch, talc, magnesium stearate, and other components.

pharmachologic effect

The drug "Biseptol" has a bacteriostatic effect on various types of pathogens. Sulfamethoxazole disrupts the metabolism of bacteria, including preventing the synthesis of dihydrofolic acid in their cells. Trimethoprim prevents the formation of nucleic acids necessary for the growth and reproduction of microorganisms, which leads to their rapid death. The active components of Biseptol tablets are absorbed in the small intestine. They penetrate into body fluids and tissues: kidneys, lungs, tonsils, prostate gland, vaginal and bronchial secretions. Sulfamethoxazole and trimethoprim cross the placental barrier and can be excreted in breast milk during lactation. 60 minutes after taking the drug, the concentration of active substances in the blood reaches the maximum value. The therapeutic effect lasts for 12 hours. The drug is eliminated from the body within 10-12 hours, mainly in the urine. So, we looked at what effect the drug "Biseptol" has. We will tell you further what it helps with.

In what cases do doctors prescribe the drug "Biseptol"?

The drug destroys various gram-negative and gram-positive bacteria and even some pathogenic fungi. It is effective against pathogens such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Morganella, Streptococcus, Salmonella, Legionella, Toxoplasma, Neisseria. It is also active against chlamydia and Vibrio cholerae. A wide range of pathogenic microorganisms sensitive to the active complex of sulfamethoxazole and trimethoprim determines an impressive list of diseases for which the drug Biseptol is prescribed. What does it help with? Often this remedy is used to treat acute respiratory tract infections (pharyngitis, tonsillitis, pneumonia, bronchiolitis), infections of the ENT organs (otitis media, chronic sinusitis). Doctors often prescribe the drug "Biseptol" for bronchitis caused by bacteria. It is worth remembering that if a cough occurs, you cannot purchase and use medicine without a doctor’s recommendation. Inflammation of the bronchi can be caused not only by bacteria, but also by viruses that are resistant to the components of the tablets. In order not to harm your body, the cough medicine “Biseptol” should be taken only after visiting a therapist. Self-treatment is unacceptable.

What do Biseptol tablets help with?

The drug is often used to treat diseases of the urinary tract and genital organs. It is effective in the presence of urethritis, including post-gonorrhea, gonococcal infection, pyelitis, chronic pyelonephritis, prostatitis. The drug "Biseptol" is often prescribed for cystitis. The thing is that in almost 80% of cases, the cause of infection in the urinary tract and inflammation of the bladder is E. coli. Biseptol tablets work well against this pathogen.

However, it is worth remembering that when treating urinary tract diseases you should follow the recommendations of your doctor. He will probably prescribe you not Biseptol tablets, but a fluoroquinolone antibiotic. Inadequate therapy and self-medication can lead to chronicity of urinary tract diseases, which are extremely difficult to treat. In addition to cystitis, the drug "Biseptol" also helps in the presence of gastrointestinal infections: typhoid fever, bacterial dysentery, paratyphoid fever, cholera. It is also effective in the presence of infections of soft tissues and skin, such as furunculosis, pyoderma or abscess. Sometimes doctors prescribe the drug "Biseptol" for the treatment of meningitis. We looked at what it helps with. Next, we will describe the regimen of use, and also talk about contraindications and possible side effects of this drug.

Instructions for use. Dosage

The duration of treatment is determined for each patient individually. It can range from 5 to 14 days. Typically, the daily dosage of the drug is calculated using the following formula: 30 mg of sulfamethoxazole and 6 mg of trimethoprim per 1 kg of body weight. Children are prescribed the drug "Biseptol" in the form of a suspension or syrup. The standard dosage for children is:

• at the age of 3 to 6 months - 2.5 ml (every 12 hours);
• at the age of 7 months to 3 years - 2.5-5 ml;
• at the age of 4 to 6 years - 5-10 ml;
• aged 7 to 12 years - 10 ml.

Children 12 years of age and older, as well as adults, should take 20 ml every 12 hours. When prescribing Biseptol tablets to patients with impaired renal function, the dosage is halved.

Contraindications and side effects of the drug "Biseptol"

It is contraindicated in patients with severe dysfunction of the kidneys and hematopoietic system. The drug "Bispetol" is not recommended for people with folic acid deficiency, as well as those with hypersensitivity to the active components (trimethoprim and/or sulfonamides). It is not prescribed for children under 3 months of age, during pregnancy and lactation. With prolonged and uncontrolled use, the drug "Biseptol" can negatively affect your well-being, including causing nausea, vomiting, diarrhea, and gastritis. In rare cases, use may contribute to the appearance of hepatitis, acute liver necrosis, and pancreatitis. Also, while taking pills, allergic reactions may occur: hives, itching or skin rash.

The drug can also cause headaches, dizziness, and cause apathy and depression. Its use in high doses can develop thrombocytopenia, anemia, agranulocytosis and impair kidney function. Therefore, you should not neglect the prescription of your doctor and exceed the dose recommended by him. Be healthy!

Biseptol is a combination drug belonging to the group of sulfonamides. It contains sulfamethoxazole and trimethoprim. The medicine is often prescribed by specialists for the treatment of various diseases caused by pathogenic microflora.

Effect of the drug

The drug is characterized by a wide range of effects against the following microorganisms:

• Protozoan microorganisms;
• Gram-positive aerobic bacteria;
• Aerobic bacteria;
• Gram-positive anaerobes;
• Gram-negative aerobic bacteria;
• Pathogenic fungi.

Biseptol also inhibits E. coli, causing a decrease in the absorption of B vitamins, nicotinic acid, thiamine, riboflavin in the intestine. The duration of the therapeutic effect is about 7 hours.

The instructions attached to the drug Biseptol state that the medication does not affect:

• Viruses;
• Corynebacterium spp.;
• Treponema spp;
• Pseudomonas aeruginosa;
• Mycobacterium tuberculosis;
• Leptospira spp.

Biseptol antibiotic or not

Antibiotics are drugs of natural or semi-synthetic origin that have an antimicrobial effect. As for Biseptol, this drug is completely synthesized and belongs to the sulfonamides. They are commonly called antibacterial chemical drugs.

Antibacterial agents kill bacteria or inhibit their reproduction and growth.

Sulfonamides penetrate into the structure of microbes instead of para-aminobenzoic acid, causing disturbances in the metabolism of their vital functions and the growth of bacteria. While doing this job, sulfonamides are not antibiotics. Medicines represent a different group of antimicrobial medications.

Sulfonamides became the first systemic antimicrobial drugs. They have been used for more than 65 years, thereby creating the risk of a mass of microbial strains becoming addicted to this group of drugs. It was possible to increase the sensitivity of pathogenic microbes by developing combination medications that combine these antimicrobial agents with trimethoprim. These include Co-trimoxazole and other analogues of Biseptol.

It is worth noting that Co-trimoxazole is a drug with a leader in side effects that are life-threatening. Danish medical academics have found that Biseptol has a negative effect on hematopoiesis, provoking a condition in which the bone marrow stops producing leukocytes - granulocytes, that is, it contributes to aplastic anemia.

This phenomenon causes a severe disorder of hematopoiesis, in which patients die within a few months without the necessary qualified assistance. This condition (aplastic anemia) causes complete atrophy of the brain, and in terms of danger it occupies a leading position together with blood oncology.

Composition and release form

The release form of the drug Biseptol may be as follows:

• Suspensions for oral administration 240 mg/5 ml – 80 ml bottle. 100 ml contains the active substances trimethoprim - 0.8 g, sulfamethoxazole - 4.0 g and auxiliary ingredients. The medicine is dispensed according to a doctor's prescription.
• Biseptol tablets contain 0.4 mg of sulfamethoxazole and 0.08 g of trimethoprim for adults. The medication used to treat children has the following dosage - 0.2 g trimethoprim and 0.1 g sulfamethoxazole. The package contains 20 tablets.
• Concentrates for injections of 480 mg (in 1 ml of product - 16 mg of trimethoprim and 80 mg of sulfamethoxazole).

Pharmacokinetics

The mechanism of action of Biseptol is as follows:

• Trimethoprim and sulfamethoxazole are completely absorbed by the digestive system when taken.
• Trimethoprim is quickly transported into cells and also instantly penetrates tissue barriers into the kidneys, lungs, bile, prostate gland, saliva, cerebrospinal fluid, and sputum. The substance is excreted through the kidneys in half the consumed volume unchanged.
• Sulfamethoxazole is supplied via the kidneys, with about 30% in the active form.

Biseptol: indications for use

The drug is intended for the treatment of infectious diseases caused by pathogenic microorganisms. Biseptol is recommended for:

• Infectious lesions of the respiratory system (bronchitis or pulmonary abscess, sinusitis, inflammation of the brain and lungs, sinusitis, otitis, flu or cold, sore throat);
• Infection of the genitourinary system (prostatitis, urethritis, cystitis, salpingitis);
• Foodborne diseases (shigellosis, cholera and paratyphoid fever);
• Skin lesions - furunculosis and pyoderma.

For cystitis or prostatitis, the effectiveness of the medicine can be observed when pathologies are provoked by the following pathogenic microorganisms: fungi, cocci, E. coli. In this case, recovery will take place quickly and effectively.

Biseptol is used to treat acute and chronic forms of these diseases.

The dosage for the treatment course is selected individually by the attending physician. Self-therapy is fraught with the risk of severe complications. Inflammatory processes in the prostate gland, leading to various diseases, are provoked by pathogenic microbes, so you need to know which treatment regimen to use in each specific situation.

Biseptol for pathologies of an infectious nature of origin of the genitourinary system is prescribed to stop the further transition of the pathological reaction into a chronic form.

In severe cases of the disease, antibacterial agents with a broad spectrum of action are added to the antiviral drug. Therapy is carried out for three weeks, after which the patient is recommended to take a month's break. Then treatment should be resumed.

Before using Biseptol, the patient should undergo laboratory testing for pathogenic flora. Based on the test results, the doctor selects the required group of medications.

AIDS is an incurable disease that kills hundreds of thousands of people around the world

Scientists are constantly developing new drug formulas to help alleviate the condition of patients. The antiviral drug Biseptol can be used to treat HIV-infected children.

Long-term studies have shown that this drug helps reduce the mortality rate of children by almost 50%. Today, in many African countries, where the disease is most common in children, Biseptol is prescribed to them. This is due to its high efficiency and availability.

Contraindications

Biseptol must not be used:

• Patients with hypersensitivity to incoming components;
• Pregnant women;
• During lactation;
• Children under 6 years of age for intramuscular administration;
• Up to 3 months of age;
• For Pneumocystis pneumonia;
• In case of hyperbilirubinemia in children;
• For bronchial asthma;
• If severe kidney failure is diagnosed;
• With folic acid deficiency;
• When a dysfunction of the thyroid gland is detected;
• For pathologies of the hematopoietic system.

Biseptol can have side effects on the body from:

The drug can provoke an allergic reaction and manifest itself in the form of itching, rash, drug fever, urticaria, fever, exfoliative dermatitis, scleral hyperemia, allergic myocarditis, angioedema.

Annotation on dosage and methods of administration

Tablets for internal use are recommended for adult patients and children over 12 years of age, 960 mg at a time. However, the medicine can be used at 480 mg per day twice. In advanced forms of the disease, the drug may be prescribed three times a day, 480 mg.

For children 1–2 years old, Biseptol tablets are prescribed in a dosage of 120 mg in the morning and evening; for children 2–6 years old, the dosage can be increased to 240 mg.

The suspension should be taken after a meal with a sufficient volume of liquid (960 mg) every 12 hours. In severe cases, the dosage of the suspension can also be increased to 1440 mg, which must be taken every 12 hours.

Biseptol in the form of syrup is intended for children. Up to 2 years it is recommended 120 mg, 2-6 years 240 mg, in the older category of people the dosage is 240-480 mg. You need to take the medicine twice a day. The duration of treatment depends on the degree of neglect of the inflammatory process and can range from several days to several months.

The drug can be used to prevent recurrences of chronic infections and urinary tract pathologies. In this case, the recommended dosage is 480 mg once before bedtime. The duration of the therapeutic course is 3–12 months.

When treating acute cystitis in adolescents and children, a regimen of 480 mg is used twice a day for three days. Biseptol for intravenous injections for adults and adolescents, 960–1920 mg every 12 hours, for children - according to age and existing standards.

In case of severe infection, intravenous or intramuscular administration of the drug is used. The drug concentrate cannot be administered with other solutions. Children over 12 years of age, as well as adult patients, are prescribed injections of 10 ml twice a day. For children under 5 years of age, the dosage of the drug is reduced by four times, and for schoolchildren - by half. In severe situations, a half dose increase is allowed for any age group. The medicine must be administered for at least 5 days (when the characteristic manifestations of the disease disappear, and then another couple of days).

Overdose

Failure to follow your doctor's recommendations for the correct use of the drug may result in negative consequences. The substance co-trimoxazole can be life-threatening. If you have unpleasant symptoms, you must stop taking this drug and perform gastric lavage, and it is recommended to do this procedure no later than 2 hours after using the drug. Drinking plenty of fluids and artificial vomiting will help improve your condition after poisoning.

In case of chronic poisoning with Biseptol, there may be a risk of leukopenia. Thrombocytopenia and megaloblastic anemia may occur. Leucovorin, recommended for use in a dosage of 5–15 mg per day, helps relieve unpleasant discomfort.

The condition after poisoning should be kept under control.

If any deviations occur, you should immediately contact your doctor and notify him of the problems.

special instructions

If rashes or diarrhea appear on the skin in the acute stage, you should immediately stop taking Biseptol. It is forbidden to take the medicine for streptococcal sore throat.

Patients are advised to drink plenty of fluids during treatment with these drugs.

During long-term drug therapy, it is necessary to monitor the parameters of the circulatory system.

It is not advisable to include green vegetables, as well as tomatoes and carrots in your diet. You should not be in direct sunlight for a long time. Biseptol is not recommended for use in case of respiratory tract pathologies. Trimethoprim contributes to changes in the serum concentration of methotrexate.

Biseptol during pregnancy

It is recommended to use the drug for pregnant women only if there is a clear positive result. In the third trimester of pregnancy, its use is contraindicated, since it can cause Botkin's disease in the child. It is advisable to take Biseptol only in liquid form.

During the therapeutic course, pregnant women due to a deficiency of folic acid in their body are prescribed this substance at a dose of 5 mg per day. For nursing mothers with any pathologies, taking this medicine is strictly prohibited.

Alcohol compatibility

Biseptol, like many other drugs, cannot be combined with alcohol and protein contained in food. If you drink alcohol and this drug at the same time, you may experience limb cramps. In such cases, an increase in pressure and body temperature is recorded, and a suffocating cough is noted.

Biseptol with alcohol can cause an allergic reaction. It may continue to occur each time you use this drug, regardless of whether alcohol was consumed or not. The most unpleasant moment in the tandem of alcohol and drugs is cerebral ischemia, which can cause death.

Analogues

Biseptol is produced by various pharmacological companies under the following names:

• Bel-septol;
• Bactiseptol;
• Babytrim;
• Bi-sept;
• Raseptol;
• Bicotrim;
• Triseptol.

Its popular analogues in the form of suspensions and tablets for children have become products made in Poland. A good substitute for this medication is the drug produced by the French company Senexi Bactrim.

The drug Co-Trimoxazole in dosages of 240 mg and 480 is produced by Pharmstandard. This medicine is an inexpensive analogue of Biseptol. There are other manufacturers producing the drug under this name. What they all have in common is affordability. In pharmacies you can also buy more expensive analogues - Bi-septin from Holland, Septrin from the English company Glaxo.

Drug price

The price range for Biseptol in domestic pharmacies is as follows:

• In tablets 120 mg – 31 rubles. (20 pcs.);
• In tablets 480 mg – 67 rubles. (20 pcs.);
• In ampoules of 5 ml - 340 rubles. (10 pieces.);
• Suspension 240 mg – 120 rub.