Anabolic steroid methandrostenolone: ​​recommendations and instructions for use. Methandrostenolone side effects

Pharmacological properties

Pharmacological group: anabolic/androgenic steroids
Androgenic activity: 40-60
Anabolic activity: 90-210
Application: oral
Chemical names: 17a-methyl-17b-hydroxy-l,4-androstadien-3-one
l-dehydro-17a-methyltestosterone
Estrogenic activity: moderate
Progesterone activity: not significant

Description of Methandrostenolone

Methandrostenolone (Dianabol, Methandienone) is a testosterone derivative, modified in such a way that the androgenic properties of the hormone (masculinization) are significantly reduced, while the anabolic properties of testosterone (promotion of tissue construction) are preserved. Having a lower level of relative androgenicity than testosterone, Methandrostenolone is classified as an "anabolic" steroid, although some androgenic side effects still occur with its use.
This drug was developed for oral administration, although in veterinary medicine it is used by injection. Dianabol is an orally administered anabolic/androgenic steroid and is used to enhance a person's physical performance.

Story

Methandrostenolone was first described in 1955. It was released to the prescription drug market in the United States in 1958 under the brand name Dianabol from Ciba Pharmaceuticals.
Ciba developed the drug with the help of Dr. John Ziegler, a physician for several U.S. Olympic teams, including weightlifters.
Ziegler says his first encounter with steroids was at the 1956 World Games, during which testosterone abuse was observed among Russian athletes. According to Ziegler, the hormone had noticeable side effects, and one athlete had such severe prostatic hyperplasia that he was forced to urinate with a catheter.
When working with Ciba, a steroid (previously synthesized) was tested that has a lower androgenicity compared to testosterone, while maintaining its anabolic properties, which was achieved by changing the basic chemical composition of testosterone so that its metabolism and pharmacokinetics in the body changed. With the help of Dr. Ziegler, Ciba brought to market one of the most effective oral "anabolic" steroid drugs ever known, Methandrostenolone.
The drug's success was rapid and widespread.
With the help of this drug, Dr. Ziegler's athletes achieved noticeable career success in a short period of time. According to reports, Ziegler was also quite impressed with the steroid's capabilities for some time. But in the early 1960s, it became clear that the advent of Dianabol had triggered a major wave of doping in sports. Dr. Ziegler's early dosage recommendations of only 5 to 15 mg per day were largely ignored, and athletes developed their own, more aggressive (and likely more dangerous) dosing strategies. Dr. Ziegler soon became disillusioned with the benefits of the drug, and ultimately sided with the opposition on the issue of sports doping.
By 1967, approximately 10 years after the first use of Dianabol by athletes, Ziegler began to categorically condemn any use of anabolic steroids in sports.
As early as 1965, the FDA began to take an interest in Dianabol and asked Ciba to describe the possible medical uses of Dianabol, and the company did so by including items such as helping frail and bone-damaged patients. In 1970, the FDA recognized that Dianabol “may be effective” for the treatment of postmenopausal osteoporosis and pituitary dwarfism (dwarfism). These changes were reflected in the drug's prescribing guidelines in the 1970s, and Ciba was allowed to continue marketing and studying the drug. The company eventually loses patent protection for the drug, and companies like Parr. Barr, Bolar, and Rugby have entered the market with their own generic versions of the drugs.
By the early 1980s, the FDA rescinded the drug's "possibly effective" designation for treating dwarfism and continued to press for more data from the company. However, there was no sufficient clarification, and in 1983 Ciba officially removed Dianabol from sales in the United States. Perhaps the company's financial disinterest played a role in this decision. In 1985, the FDA removed all generic versions of Methandrostenolone from sales in the United States. In most Western countries, the drug is also being withdrawn from pharmaceutical markets due to the fact that the drug is recognized as a doping agent in most sports. Methandrostenolone is still produced today, but usually in countries with looser control and regulation of prescription drugs, and by companies that still focus on the black market for sports drugs.

Dosage forms

Methandrostenolone is widely available in the pharmaceutical and veterinary markets. Composition and dosage may vary depending on the country and manufacturer.
Methandrostenolone was developed as an oral anabolic steroid containing 2.5 or 5 mg of steroid per tablet (Dianabol). Modern brands usually contain 5 or 10 mg of steroid per tablet. Methandrostenolone can also be found in injectable veterinary medications. These are usually oil-based preparations containing 25 mg/ml of steroid.
Structural characteristics
Methandrostenolone is a modified form of testosterone. It is distinguished by: 1) the addition of methyl groups on carbon 17alpha, which protects the hormone when administered orally; 2) the introduction of a double bond between carbon atoms 1 and 2, which reduces its relative androgenicity.
The resulting steroid also has a much weaker relative affinity for androgen receptors than testosterone, but at the same time exhibits a much longer half-life and lower affinity for serum proteins in comparison. These features (among others) allow Methandrostenolone to be considered a very potent anabolic steroid, despite its weaker receptor binding affinity. Recent studies have further confirmed that the main function of the drug is interaction with cellular androgen receptors.

Side effects of Methandrostenolone

Side effects of Methandrostenolone (estrogenic)

Side effects of Methandrostenolone (hepatotoxicity)

Methandrostenolone is a c17 alpha alkaline compound.
This protects the drug from deactivation in the liver, allowing a very high percentage of it to enter the bloodstream after ingestion. C17 alpha alkaline anabolic/androgenic steroids may be hepatotoxic. Long-term exposure or high dosages may cause liver damage. In rare cases, life-threatening dysfunction may develop. It is advisable to visit your doctor periodically during each cycle to monitor your liver function and overall health. Use of c17 alpha-alkylated steroids is usually limited to 6-8 weeks to avoid escalation of liver strains.
Studies have shown that taking Methandrostenolone for several weeks at a dose of 10 mg per day or lower causes minimal effects on the liver. At a dose of 15 mg per day, most patients begin to experience liver dysfunction and increased bromsulfalein retention (a marker of liver stress). Even when using 2.5 and 5 mg per day, increased bromsulfalein levels were reported in patients. Severe liver complications are quite rare, given the intermittent nature of the use of oral anabolic/androgenic steroids, although they cannot be completely excluded, especially when using Methandrostenolone in high doses and/or long-term use.
When using any hepatotoxic anabolic/androgenic steroids, it is recommended to take a liver detoxification supplement such as , or .

Side effects of Methandrostenolone (cardiovascular)

Anabolic/androgenic steroids can have a detrimental effect on cholesterol levels. This includes trends toward lower HDL (good cholesterol) levels and higher LDL (bad cholesterol) levels, which may contribute to the risk of atherosclerosis. The extent of the effects of anabolic/androgenic steroids on serum lipids depends on the dose, route of administration (oral or injectable), type of steroid (or not), and the level of resistance to hepatic metabolism.
Methandrostenolone has a strong effect on cholesterol levels in the liver due to the fact that this substance is not, and due to its structure can resist breakdown in the liver, in addition, the route of administration of the drug is also an important condition. Anabolic/androgenic steroids may negatively affect blood pressure and triglyceride levels, decrease endothelial relaxation, and promote left ventricular hypertrophy, which together potentially increases the risk of cardiovascular disease and myocardial infarction. To reduce the risk of cardiovascular deformities, it is recommended to perform vigorous exercise and minimize the intake of saturated fat, cholesterol and simple carbohydrates during the entire period of active use of AAS (anabolic / androgenic steroids). Supplemental intake of fish oil (4 g per day), natural cholesterol and antioxidants such as or products with comparable ingredients is also recommended.

Side effects of Methandrostenolone (testosterone suppression)

All anabolic/androgenic steroids, when taken in doses sufficient to increase muscle mass, suppress the production of endogenous testosterone.
Methandrostenolone is no exception, and is known for its strong effects on the hypothalamic-pituitary-testicular axis. Clinical studies using 15 mg per day in endurance-trained men for 8 weeks showed an average reduction in plasma testosterone levels of approximately 69%. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months after taking the drug. Note that long-term hypogonadotropic hypogonadism may develop secondary to medical intervention.

Instructions for use of Methandrostenolone (general)

Research has shown that oral administration of anabolic steroids with food may reduce their bioavailability. This is caused by the fat-soluble nature of steroid hormones, which allows some drugs to dissolve undigested dietary fats, reducing their absorption from the gastrointestinal tract. For maximum benefit, the steroid should be taken on an empty stomach.

Instructions for use of Methandrostenolone (for men)

The original Dianabol prescribing guidelines recommended a daily dose of 5 mg, administered on an intermittent basis for no more than 6 consecutive weeks.
A break of 2 to 4 weeks is recommended before resuming treatment. To improve physique or performance, the drug is also used intermittently, with cycles typically lasting 6 to 8 weeks, interrupted by 6 to 8 weeks of rest. Although a low dose of 5 mg per day may be effective in improving performance, athletes typically take much larger doses. A daily dosage of three to six 5 mg tablets (15-30 mg) is the most common, and usually produces very impressive results. Some use even higher dosages, but this practice usually results in a greater risk of side effects and is generally not recommended.
Dianabol combines well with many other steroids. For example, with a mild anabolic ®. Combined use can produce exceptional gains in muscle mass and strength, with side effects not much worse than would be expected from Dianabol alone. Long-acting testosterone esters, such as enanthate or cypionate, can only be used to increase mass. However, given the high estrogenic/androgenic properties of this androgen, side effects may be more pronounced. The result will also be more pronounced, which usually makes up for all the shortcomings of the drug. As discussed earlier, adjuvant medications may be added to reduce the side effects associated with these types of cycles.
The half-life of Dianabol is only about 3-5 hours. The once daily dose will be reflected in differences in drug concentrations in the blood, rising and falling throughout the day. The user thus has the choice whether to split the dose throughout the day or take it all at once. It is usually recommended to divide it and try to regulate the concentration of the substance in the blood. This will, however, be accompanied by a lower maximum blood concentration than if all tablets were taken at the same time. Both options work well, but anecdotal evidence supports the benefit of single daily doses for better outcome. With this schedule, it seems logical to take the pills in the morning, which will promote significant androgen metabolism during the daytime, increasing nutrient absorption, especially during the critical hours after exercise.

Instructions for use of Methandrostenolone (for women)

Being a moderate androgenic steroid, Dianabol is especially popular among men. When used by women there may be a strong risk of masculinization. Some women still experiment with the drug, and often quite low doses (2.5-5 mg) of the steroid are quite effective for muscle growth. Studies have shown that most women notice the appearance of acne after taking the drug, which indicates its high androgenicity, with a dosage of 10 mg per day. Children may notice virilizing effects occurring as early as at a minimum dose of 2.5 mg per day.

Methandrostenolone analogues

The number of Methandrostenolone dosage forms sold is frightening. Western medicine has completely done away with this steroid since it was found to have no real therapeutic value. Its potential existence is justified as doping support to improve performance, and nothing more.
Thus, it is impossible to find legal Dianabol from the USA, Canada or Western Europe.
The drug is produced exclusively in areas such as Asia, South America (limited), and Eastern Europe. Ignore drugs made in Italy or Spain, etc. They are illegal. Let's talk about the most popular legal brands on the black market.
British Dispensary Anabol Pills from Thailand are still very popular. Due to the large volume of counterfeit goods, the manufacturer has introduced three methods for detecting counterfeits. Firstly, there is a holographic sticker attached to each package of tablets. Secondly, the company logo - a snake - is printed on the tablets themselves. Finally, each package features the company logo. Please note that Anabol is in such great demand that some advanced counterfeiters duplicate the company's hologram, pill coloring and packaging logo. Such fakes look quite believable, but are still somewhat different from the original.
Be sure to very carefully compare your product with the photographs of the original Anabol drug. Please note that the product packaging contains a computer-printed batch number and expiration date, just like Anabol 10.
British Dispensary also produces a 10mg version of the drug called Anabol 10. The product provides the same protection system as regular Anabol, but is packaged in smaller yellow and white boxes. The tablets themselves are identical in shape to the 5 mg version, and they also feature the company logo. The only difference between the two drugs is the color, which this time is not pink, but yellow.
In Russia, the Akrikhin company still produces the generic “Russian D-Bol” (metahapoctehorоh), the company name in Cyrillic is Akpnxnh. The box is purple and contains 10 strips of 10 tablets each. This form of Dianabol has always been highly rated by users. Counterfeits of the drug are quite common, and most of them are rather poor copies of the original, often produced in bottles instead of proper foil and plastic packaging. However, it cannot be said that the drug will necessarily be original if it is properly packaged, so carefully compare the product with photographs of the original. Please note that the manufacturer has started releasing a version of the product for the Ukrainian market. This drug can be identified by the Akpixih company name on the packaging. Some people mistakenly assume that this is a fake, since the inscription looks more like a typo.
Naposim from Romania is still available on the market. The drug is supplied in white boxes containing 10 triangular-shaped tablets, packed in foil and plastic. Please note that the original Naposim foil strips are stamped with the date and lot number on both ends. Some counterfeiters have in the past overlooked this fact by placing the date and lot number on only one end. In addition, there is a small bump in the center of each Naposim tablet on the strip (soft strip of packaging). In the past, counterfeit products could be identified by the smooth surface of the strip. Also, make sure that the triangular shape of the tablets is clear with sharp corners. One of the latest fakes looked more like the Star Trek logo than a triangle. Also, note that in some of the original strips the word "metandienona" is used instead of "metandienonum". These are just variations of the export name of the product, and nothing more.
Also commercially available is Danabol DS from Body Research/March Pharmaceutical Company from Thailand. The tablets are shaped like small blue hearts. This product is often counterfeited, so be sure to check its authenticity when purchasing.
Methandon and Melic from Thailand are both legal drugs that come in packs of 1000 tablets each. Both products are relatively rare on the black market today, although still in production. Their not very large abundance is a consequence of the much greater popularity and recognition of the drug Anabol, which dominates the Thai Dianabol market, despite increasing competition. Both products contain pink 5-sided tablets like Anabol and are very similar in appearance except for the packaging. The Methandone product (plain white tablets) is the most different from the rest, with the letters "ES" engraved on each tablet of the drug.
3 mg Anabolex tablets from the Dominican Republic are still
safe to buy. Please note that each tablet contains 1.5 mg of the drug Periactin, used as an appetite stimulant. This is an antihistamine that may cause drowsiness. Make sure that the product is packaged in modern blue packaging, and not in white as in the past. Currently, such packaging has long disappeared from sale.
Metanabol from Poland is another legal brand, but make sure you buy strips of 20 tablets.
Balkan Pharmaceuticals from Moldova produces Methandrostenolone under the name Danabol. The drug is supplied in foil and plastic strips of 20 tablets each. Currently, both versions of the drug are produced - 10 and 50 mg. No fakes known.
Jinan Pharmaceuticals in China produces a 10 mg version of the drug under the export name Anahexia. The product is available in foil and plastic packages of 20 tablets per package.

Bodybuilders all over the world practice the use of approved drugs from the pharmacy during their sports activities. In addition to vitamins and medications that are aimed at protecting and restoring the body’s performance, athletes are interested in legal drugs that have an anabolic effect.

The list of such drugs includes very different drugs that are available to both athletes and ordinary citizens. The difference between pharmaceutical steroids and their chemical prototypes is that they are practically harmless to the human body. At the same time, their acceptable effectiveness is noted, which makes it possible to increase up to 15 kg of muscle tissue in 3-4 months.

Many athletes regularly use legal pharmaceutical steroids during the competitive season, since they are not prohibited and are not detected during doping control.

This drug blocks extragen receptors and stimulates the production of gonadolebyrin, which results in increased testosterone production. As a result, a person who regularly takes tamoxifen, according to the instructions, experiences significant growth in muscle tissue, which contributes to a certain definition of the body.

Tamoxifen is taken 20 mg, 1-2 times a day for 2 weeks. The drug acts, although slowly, but steadily.

When taking this drug, you should expect side effects such as nausea, vomiting, loss of appetite, and possible development of venous thrombosis.

The basis of this drug are natural hormone-like substances that are secreted by some arthropods. In addition, a similar substance is released from plants such as Leuzea safflower. Entering the human body, this substance causes protein synthesis, which leads to an increase in muscle volume. In addition, this product has an antioxidant and anti-catabolic effect, and also triggers fat burning mechanisms, while simultaneously reducing cholesterol levels in the blood.

Side effects are possible only in cases of overdose, which causes allergic reactions in the form of skin rashes, disturbances in the digestive tract, and headaches.

Safinor

This is a combination drug based on herbal components that has a positive effect on the human body. It is used by bodybuilders to increase muscle volume, which is associated with the activation of metabolic and neuroregulatory processes, as well as stimulation of repair processes and improvement of myocardial function.

The drug is taken 2-4 times a day, 1-2 tablets after meals. The course of treatment can be about 5 weeks, with a minimum period of treatment of up to 7 days. Between each course of administration there should be a break of at least 3 weeks.

While taking the drug, a negative effect is possible, which manifests itself in the form of skin itching, insomnia and irritability. If such negative effects occur, the dose of the drug should be reduced or discontinued completely.

Alvezin

This is also a combination drug based on herbal components, which has a pronounced anabolic effect. At the same time, there is a drug obtained on the basis of artificial components.

The basis of the drug are vital amino acids, which help increase the volume of muscle tissue as a result of stimulating protein synthesis and controlling this process.

The drug is administered into the human body intramuscularly or intravenously, although the latter option is more preferable. The dose of this drug is limited to 400 ml, divided over 2-3 days. It is possible to take the drug in courses of 5 weeks, with breaks of 3 weeks or no less.

The drug has a metabolic effect, with the regulation of endogenous processes in the athlete’s body. The product is not highly effective, but is used very actively in bodybuilding. This is due to its stable effect, which helps to increase muscle volume and increase endurance.

In general, it has a very positive effect on humans, improving protein metabolism processes, restoring liver function and stopping some changes in the myocardium.

Potassium orotate intake is limited to a dose of 2 mg per day. The substance is taken 3-4 times a day 1 hour before meals. In order for the effect of taking this drug to appear, it should be taken for up to 40 days. In case of severe overdose, side effects may occur in the form of dermatoses and disruptions in the digestive tract.

A combined drug based on herbal components, which has a hepatoprotective effect and an anabolic effect. Bodybuilders use this drug because of its versatility. The drug Liv 52 helps restore liver function by cleansing it of harmful components that may remain in the liver after taking anabolic drugs of “chemical” origin. In addition, protein metabolism processes are normalized, which helps to increase muscle mass.

The drug is taken half an hour before meals, 2-3 tablets 3 times a day. The course can last from 20 to 40 days, after which you can take a break of up to one month and repeat taking the drug.

There may be side effects of the drug, which include: loss of appetite, gastrointestinal disturbances, vomiting, nausea, etc.

This is a very important amino acid, which is an integral part of proteins. It participates in the process of growth of the human body in general. In addition, it is part of many substances that are so necessary for the normal functioning of the human body.

Methionine is actively involved in metabolism, which promotes active fat burning. In addition, it is involved in the synthesis of creatine, adrenaline and other hormones, as well as in the rapid gain of muscle mass.

The drug is taken 30 minutes before meals, 3-4 times a day, 1.5 grams. The course of taking the drug can be from 10 to 30 days, with a break of up to 2 weeks.

As for side effects, they may include vomiting and nausea. In this case, it is recommended to limit the use of the drug or stop taking it altogether. In case of allergic reactions, it is advisable to consult a doctor for advice.

Methandrostenolone (lat. methandrostenolon) is a drug that is an anabolic steroid. In clinical practice, the medication is used in the treatment of a number of diseases of the musculoskeletal system and other disorders. It is often used in combat sports, bodybuilding and other sports.

Some athletes believe that this drug is an effective recipe for quickly gaining muscle mass, increasing strength and endurance. Often the training program includes a Solo course using this medicine. However, the consequences of irrational use of this anabolic steroid can be fatal. The medication can cause severe harm to the human body and cause disability, so you should not take it without a doctor’s prescription.

Release form, composition and packaging

The auxiliary components of the drug depend on its dosage form. In tablet form, the excipients are starch, sugar, and steric acid. The preparation in the form of an injection solution contains prepared water.

Pills

Methandrostenolone tablets are packaged in plastic blisters of 10 pcs. A cardboard pack may contain 1, 2 or 10 blisters.

Ointment

This drug is not available in ointment form.

injections

The solution for intramuscular injection is available in glass containers of 100 ml, as well as in ampoules of 5 ml. The solution is additionally packaged in cardboard boxes, which include instructions for use.

pharmachologic effect

The active substance Methandrostenolone has an activating effect on the genetic structures of the cell, which increases the production of RNA and DNA and leads to an increase in protein concentration. The ability of the drug to enhance the activity of enzymes in the tissue respiration chain, accelerate ATP synthesis and the rate of oxidative phosphorylation has been proven.

The anabolic effect against the background of weak androgenic activity helps to suppress catabolic processes.

Weakly expressed androgenic activity is expressed by the ability to stimulate the development of male secondary sexual characteristics. The medication has a pronounced antiallergic effect, because is able to increase the concentrations of the C1 fraction of the complement inhibitor, as well as reduce the production of C2 and C4 complement. The anabolic effect of the drug leads to a stable increase in muscle mass and a gradual thinning of the fat layer. This aspect of the drug’s action contributes to the appearance of a negative nitrogen balance.

After taking the drug, the active substance is quickly absorbed into the walls of the gastrointestinal tract. In this case, most of the dose is metabolized in the liver. The remaining amount of the active component Methandrostenolone is bound by 90% by blood plasma proteins. During the biotransformation process, inactive metabolites appear. The effect lasts for about 14 hours. Metabolites are excreted by the kidneys.

Indications for use of Methandrostenolone

Most often, this drug is used in the treatment of protein metabolism disorders and exhaustion resulting from operations, severe injuries, burns, and radiation therapy. The indication for the use of Methandrostenolone is a progressive form of muscular dystrophy.

The medication is prescribed for diabetic angiopathy.

Methandrostenolone is indicated for glucocorticoid-induced myopathy. The medication can be used to a limited extent in the treatment of bone fusion disorders in fractures. The use of this anabolic is indicated for certain types of dwarfism and delayed puberty in boys. The medication can be used to a limited extent in the treatment of encephalopathy that occurs with alcoholic hepatitis.

Application of Methandrostenolone

Most people prefer to use the tablet form of this medication. This anabolic steroid is in most cases taken orally. It is advisable to take the tablets after meals. The treatment regimen is selected individually for the patient. In most cases, adults are prescribed this anabolic steroid in a dose of 10 to 15 mg per day when treating existing disorders.

In severe cases, the dose can be increased to 30-50 mg per day.

The maintenance dose of the medication is 5-10 mg per day. The course of treatment with Methandrostenolone is from 30 to 60 days. After that, you need to take a 1-2 month break. A solo course used by athletes involves taking 30 mg per day, and the dose should be divided into 3 doses.

How to prick

The solution should be injected in a dose of 3 to 5 mg. The solution is used for intramuscular injections. The course of treatment with an injection solution should not exceed 14 days.

Side effect

The use of Methandrostenolone can cause great harm to the human body. Gynecomastia is often observed in men involved in spotting and abusing this medication. This side effect can occur when using both solution and tablets. The development of gynecomastia is associated with the conversion of the active substance into estrogen.

Long-term use of the medication often affects the liver.

Be sure to take tests and monitor blood counts for early detection of signs of disruption of the organ.

The most dangerous adverse reaction from taking an anabolic is hepatonecrosis. A symptom of this disorder is dark liquid feces, nausea, vomiting with blood impurities and deterioration in the general condition. Perhaps the appearance of hepatic purpura, hepatocellular carcinoma, cholestatic hepatitis and other disorders. In women, against the background of this medication, the appearance of secondary male sexual characteristics is possible.

Increased risk of hypercalcemia, bladder irritation and reduced sexual function. Often, when using Methandrostenolone, there are signs of disruption of the cardiovascular system, a pronounced increase in blood pressure, iron deficiency anemia and a tendency to bleed.

In older people, taking the medication increases the risk of developing representative gland hyperplasia.

While taking the medication, peripheral edema may occur.

Contraindications to the use of Methandrostenolone

The use of Methandrostenolone is contraindicated in the presence of hypersensitivity to the individual components of the drug. This medication should not be taken if you have a history of breast cancer, even if the disease is in remission.

You can not use this anabolic steroid in the presence of signs of prostate adenoma.

Contraindications for the use of Methandrostenolone are renal and hepatic insufficiency, nephrosis and hypercalcemia.

special instructions

With extreme caution, it is necessary to use the medication in the treatment of chronic heart failure. It is necessary to undergo a complete examination before taking the drug in the presence of a history of diabetes mellitus and coronary atherosclerosis. The medication should be used with extreme caution in patients who have experienced myocardial infarction.

Use during pregnancy and breastfeeding

This anabolic steroid cannot be used during pregnancy or while breastfeeding a child.

How to take with violations of kidney function

If you have acute or chronic kidney disease, it is better to avoid using Methandrostenolone.

Use in children

Children are prescribed the drug strictly according to indications. The daily dose is divided into 1 or 2 doses.

The dosage is selected individually. For children under 2 years of age, the drug is prescribed at a dose of 0.05-0.1 mg. For children from 2-5 years old, the drug is prescribed at 1-2 mg per 1 kg of weight. In the treatment of children from 6 to 14 years old, the drug is used at 3-5 mg per 1 kg of weight.

Overdose

In case of an overdose, an increase in the size of the liver is possible.

In this case, it is necessary to discontinue the drug, perform gastric lavage and symptomatic treatment.

Drug interactions

While taking Methandrostenolone, dosage adjustment of antiplatelet agents, anticoagulants and hypoglycemic agents is necessary, because this anabolic increases the effect of these medications.

Tablets white color, ploskotsilindrichesky, with a facet

Compound

1 tablet contains methandienone 5 mg

Excipients: sugar, potato starch, stearic acid.

Release form

Pills.

Pharmacological group

Anabolic agents for systemic use. Anabolic steroid. Androstano derivatives.

ATS code A14 AA 03.

Pharmacological properties

Pharmacological. Methandienone is a synthetic steroid that has pronounced anabolic and weak androgenic properties. Stimulates protein synthesis in the body, causes retention of nitrogen, calcium, sodium, potassium, sulfur, chlorides and phosphorus, which leads to an increase in muscle mass and accelerated bone growth, water retention in the body.

Pharmacokinetics. It is quickly and completely absorbed from the gastrointestinal tract; low bioavailability is due to the presence of a first-pass effect through the liver. In the blood, 90% binds to specific carrier globulins. It undergoes final biotransformation in the liver with the formation of inactive metabolites. Excreted by the kidneys. Duration of action - up to 14 hours.

Indications

• Cachexia of various origins;
• disorders of protein metabolism after severe injuries, infectious diseases, burns, surgeries, radiation therapy
• osteoporosis of various origins; progressive muscular dystrophy;
• prevention of myopathy and osteoporosis during treatment with GCS;
• delayed formation of callus after fractures.

In pediatric practice, the drug is indicated for growth retardation, Shereshevsky-Turner syndrome, anorexia and malnutrition.

Directions for use and doses

Methandrostenolone is prescribed orally before meals. The initial dose is 10 - 15 mg/day, in some cases the dose can be increased to 30 mg/day. Maintenance dose - 5 - 10 mg / day. The maximum single dose is 10 mg, the maximum daily dose is 50 mg. The course of treatment is 4 - 8 weeks; the interval between courses is 1 - 2 months.

For children from 6 to 14 years of age, the drug is prescribed at a dose of 2.5 mg (half a tablet) - 5 mg/day daily or every other day. The course of treatment should not exceed 4 weeks; breaks between courses are 6 - 8 weeks.

Side effect

• Dyspeptic disorders: nausea, vomiting, diarrhea, abdominal pain
• hepatocellular carcinoma, jaundice;
• allergic reactions;
• increased bleeding;
• depression, sleep disturbance;
• muscle cramps
• prostate adenoma and adenocarcinoma;
• breast lumps;
• gynecomastia in men;
• symptoms of virilization in women (hirsutism, baldness, irreversible decrease in the timbre of the voice, menstrual irregularities, depression of ovarian function, enlargement of the clitoris)
• polyuria and increased urination
• swelling
• leukemoid reaction;
• premature closure of growth plates in children and adolescents.

Contraindications

• Hypersensitivity to the drug
• pregnancy, breastfeeding period
• prostate cancer or adenoma
• acute or chronic prostatitis
• breast cancer in men;
• severe liver damage, liver failure
• coronary heart disease, myocardial infarction, heart failure
• diabetes
• hypercalcemia.

Overdose.

Symptoms: increased side effects Treatment is symptomatic.

If signs of virilization appear, the drug must be discontinued.

Features of application.

To achieve the optimal effect, simultaneously with the use of methandrostenolone, the patient should receive an adequate amount of proteins, fats, carbohydrates, vitamins and minerals with food.

Methandrostenolone (methane): general information about this drug and instructions for its use will be given here. Both the positive effect and the possible risks from its use will be considered. Let's talk about similar tools, as well as where and how to buy this anabolic.

About the drug "Methandrostenolone"

The drug methandrostenolone (in the slang of bodybuilders - just "methane") is one of the most popular (and maybe the most) anabolic steroids. Essentially, it is a synthetic and modified testosterone hormone. It was originally released in the USA in 1958 under the name "Dianobol". It is a powerful doping and promotes an active increase in the muscle mass of athletes in a very short period of time. It is used both in sports medicine and in secular medicine for the treatment of a number of diseases, such as:

• Fractures.
• Burns.
• Kidney failure.
• Muscle dystrophy.
• Drug myopathy.
• Protein metabolism disorder. Protein deficiency.
• Infectious diseases leading to protein loss.
• With sprains and injuries, to accelerate tissue repair.
• Growth retardation, as well as physical and sexual development. Particularly in children and adolescents.

It is available both in tablets and as a solution for injection. Most effective for those who have started using it recently. For seasoned bodybuilders, with long-term use, the effectiveness decreases over time. Methandrostenolone is sold in pharmacies only by prescription, but purchasing the drug in other places will not be difficult, but more on that later.

The effect for bodybuilders from the use of "Methane"

Among jocks-“chemists” (those who like to stuff themselves with all sorts of chemicals for greater effect from working out in the gym), where this anabolic is very popular, there are rarely any doubts about whether methane is good for muscles. It’s not surprising, because with its help you can turn from a stunted and homely goner into a pumped-up and brutal athlete in a fairly short period of time.

Here are its most effective qualities:

• Active and rapid muscle building.
• Increase in strength indicators.
• Acceleration of protein synthesis.
• Strengthening bones.
• Increased appetite.
• Slowing down the process of protein breakdown (anti-catabolic effect).

As you can see, the effect of methandrostenolone is very noticeable for bodybuilders, so many find it difficult to resist the temptation to start using it. Whether this is good or bad is a personal matter for each athlete. Indeed, this substance provides a number of advantages over those who do not like “chemistry” and prefer chicken breast to some kind of chemicals. But methane also has side effects, which will be discussed now.

side effects of methane

Like any other medicine, methane tablets (or injections) have their side effects:

• Increased blood pressure due to water retention in the body.
• Tachycardia.
• Stomach and intestinal upset.
• Production of the female sex hormone estrogen. As a consequence, the appearance of secondary sexual characteristics.
• Iron deficiency and associated anemia.
• Skin rashes. Acne and pimples.
• Excessive concentration of calcium in the blood.

And this, alas, is not all the side effects of this drug.

There is also a myth that almost all “jocks” who are on steroids supposedly have something wrong with them (well, you understand what exactly). However, the athletes themselves refute this myth and believe that it is complete nonsense. I am inclined to agree with them, because many athletes who are on anabolic steroids and use methane for muscle growth have couples, are married and somehow even manage to reproduce. So whether to believe in this myth or not - think for yourself. But if you still decide that you cannot do without steroids, then in order to avoid such a scenario and minimize the harm from the “side”, it would not hurt you to find out what the instructions for using methane look like, read it carefully and follow it exactly follow.

Instructions for solo use and dosage

The optimal daily dose of the drug is 20-30 mg. It is best to take methane twice a day, morning and evening, from 6 to 9 am, and 18-21 pm. It is better to take after meals. Frequent and long-term use is highly not recommended, as the body becomes accustomed to the active substance and its effectiveness decreases over time, or even disappears completely.

Therefore, methandrostenolone should be taken with regular breaks. The duration of one course should not exceed one and a half months. The pause between courses should be approximately the same.

It is also worth noting such a scheme of application as a “pyramid”. According to this scheme, the dose of the drug is first gradually increased, and then just as gradually decreased. But there is an opinion that such a scheme is extremely ineffective and does not justify itself. It is better to use methandrostenolone, or its analogues, twice a day, 10 mg per dose, and do not change the dosage throughout the course.

An important point: some bodybuilders, for the sake of greater effectiveness, sometimes significantly increase the dose of the drug. This is strongly not recommended! Otherwise, at a minimum, the myth about sexual dysfunction may well become a reality for you! And in addition, new growths such as horns, hooves and pig's penny may appear. Jokes aside, but you definitely shouldn’t expect anything good from this. Don’t become enemies to your body for the sake of extra pounds of meat on your body! It’s better to read real reviews about methane and other “chemicals”.

Analogues and substitutes

Each medicine has its own analogues and substitutes. Methane is no exception. Here is a list of the most famous analogues:

• Primobol.
• Strombafort (Stanozolol).
• Danabol, Methandienone, Dianabol, Nerobol are other names for the same good old methane.

With the help of methane, you can increase, on average, 9-10 kg of “meat” in a course of 6 weeks. However, you can subsequently lose it very quickly if you do not take into account and neutralize the so-called. the rollback phenomenon, which we will discuss in more detail below.

The rebound phenomenon and combined use of methane with other drugs

A separate line is worth mentioning about such a phenomenon as. It lies in the fact that after finishing the next course of using methane (as well as any other steroids), the muscle mass gained by the athlete during this time begins to rapidly decrease, practically negating the entire positive effect of taking the drug.

It is impossible to completely get rid of this effect - it will catch up with you in any case, but it is quite possible to minimize it. To do this, you need to wisely choose the course of use, and the combined use of steroids with other drugs. Here are a number of important recommendations and methods for mitigating rollback:

• The so-called “bridge” between courses of taking methandienone. Its essence is that during the break between doses of “metashka” your body still receives a certain dose of testosterone. For this you can use other steroids made from testosterone esters. Such drugs as: Omnadren; Testosterone cypionate; Testosterone enanthate; Sustanon.
• Since such an important male organ as the testicles is responsible for the production of testosterone, the course should be selected with an emphasis on restoring their functionality, which will noticeably decrease if you abruptly stop taking anabolic steroids. As a rule, in such cases, the use of the hormonal drug gonadotropin is recommended.
• A significant reduction in training intensity will be required. No excessive loads. During this period, training will work against you and your muscles in particular. Of course, you shouldn’t completely abandon them either, so as not to lose shape and tone, but you should train in an energy-saving mode.
• You should saturate your diet with protein foods, but this is not enough. You will have to take protein supplements, or...
• During the course, it will also not be superfluous to use the combined intake of methane, in conjunction with other steroids, for example, with stanozolol (Winstron) or the usual supplement -. If you correctly create a combined course, the rollback will not be so noticeable.

Post cycle therapy

During pauses, after taking anabolic steroids, to restore the hormonal system and eliminate negative consequences, it is recommended to carry out post-cycle therapy. Before that, you need to visit a doctor so that he can prescribe all the necessary tests for hormones. Based on these analyzes, you will be individually selected a course of PCT.

Most often, athletes are prescribed medications such as:

• Gonadotropin.
• Proviron.
• Tamoxifen.
• Clomiphene.

In general, anabolics for hormonal balancing. Methane has a bad effect on the liver, so it is recommended to help it by drinking hepatoprotectors - Essentiale or Essliver Forte. But only a doctor should prescribe this to you!

Where to buy methane and at what price

As mentioned above, buying steroids in a pharmacy, if you are a healthy person, is almost impossible. Therefore, most often athletes look for such products on specialized sites, visit forums, and also learn through familiar places where methandrostenolone and other anabolics are sold. So it's already a black market.

In many countries, anabolics are now considered far from harmless drugs. Their production and sale are considered illegal in the Russian Federation and are equated with drugs. But, if you wish, you can still buy methandrostenolone. Pricing may vary by region and by vendor. The cost on the “black market” currently ranges from 1000 to 1500 rubles for 100 5 mg tablets.

The most popular methane producers

The following brands that produce methandienone and its analogues are most popular among athletes:

• LA Pharma s.r.l. -Italy.
• "British Dispensary" - Founded in the UK, later moved to Thailand.
• "Body Research" - Thailand.
• ZPHC Zhengzhou Pharmaceutical - China.
• "Global Anabolic" - Hong Kong.
• "ERGO MRC" - Belgium.
• "British Dragon" - Thailand.
• Axio Labs is a subsidiary of British Dragon.
• Kubera Pharma - India.
• "Rajjay" - India.