Ersefuril capsules, instructions for use. "ersefuril" - intestinal antiseptic, antidiarrheal drug

Ersefuril is an antiseptic used to treat intestinal disorders.

Available in the form of hard gelatin capsules and suspension for oral administration. The effect of Ersefuril depends on the dosage. In lower dosages the effect is bacteriostatic, and in higher doses it is bactericidal.

This medication is well tolerated by the body and has a minimal range of side effects. Therefore, it is used to treat both adult patients and children over the age of one month. The drug is intended for internal use.

Clinical and pharmacological group

Intestinal antiseptic. Antidiarrheal drug.

Terms of sale from pharmacies

Can buy without a doctor's prescription.

Price

How much does Ersefuril cost in pharmacies? The average price is 450 rubles.

Composition and release form

Intestinal antiseptic is available in the following versions:

1. Ersefuril capsules are hard, gelatinous, containing yellow powder inside. Each capsule contains 200 mg of nifuroxazide and a number of auxiliary components.
2. Capsules of 14 pieces are packaged in blisters, which in turn are packaged in cardboard packaging. The pack may contain 1 or 2 blisters with capsules along with the included instructions for the drug.
3. Ersefuril suspension (4%) is a homogeneous liquid with a pleasant banana odor. One measuring spoon (5 ml) contains 200 mg of active substance. Available in 90ml glass bottles.

Pharmacological effect

The therapeutic effect of Ersefuril according to the instructions is to block the activity of the enzyme dehydrogenases - substances that ensure the implementation of reactions of fat, carbohydrate metabolism and oxidation in the microbial cell. Nifuroxazide inhibits the tricarboxylic acid cycle, respiratory chains, destroys the membrane and prevents the implementation of a number of biochemical processes in cells that are the “culprits” of intestinal infection.

The action of Ersefuril also consists in activating the patient’s immunity, increasing the complement titer and phagocytosis - a process in which cells hostile to our body are absorbed by special microorganisms (phagocytes). The use of Ersefuril in therapeutic doses provides a bacteriostatic effect of the drug, and in higher dosages it has a bactericidal effect.

The drug is effective against gram-positive (Streptococcus, Staphylococcus, Clostridium) and gram-negative (Salmonella, Escherichia coli, Shigella, Enterobacter, Klebsiela, Vibrio cholerae) microorganisms.

Reviews of Ersefuril do not indicate a negative effect of the drug on the saprophytic intestinal flora involved in the formation of immunity - that is, the use of the drug does not cause dysbacteriosis.

According to medical studies, resistance of bacterial strains to the drug does not develop. When the body is infected with enterotropic viruses, Ersefuril prevents the occurrence of bacterial superinfection.

According to reviews, Ersefuril is used for acute bacterial diarrhea, effectively restoring eubiosis (balance) of intestinal flora.

Indications for use

The drug is prescribed for acute diarrhea caused by bacteria, without a sharp deterioration in health, increase in body temperature, or fever. Before use, it is necessary to verify the absence of infestation (infection with worms). If the diarrhea turns out to be infectious in nature with symptoms signaling an invasion, the introduction of antibacterial therapy is required.

To prevent dehydration, if necessary, rehydrate the body, that is, restore normal water-salt metabolism.

Contraindications

The main contraindication is hypersensitivity to the excipients or to the main one (nifuroxazide) in the drug. Before use, you must carefully read the composition of Ersefuril to identify possible prohibited components. Particular attention should be paid to fructose, which is not tolerated by the body in some categories of people.

Contraindications are pregnancy, age less than 6 years and helminthic infestations.

Prescription during pregnancy and lactation

At the moment, there is no scientific information about the possible consequences of using the drug during pregnancy. For this reason, the appointment of Ersefuril is possible only under the strict supervision of a doctor in a short-term form. If there are no safer analogues, then the drug is prescribed in cases where the disease has a progressive stage and there is a risk for the expectant mother. In this case, it is recommended to use a remedy to save the woman’s life.

During lactation, the active substance can enter the child’s body, as it tends to penetrate into breast milk. If possible, you should abandon the drug or reduce the dose to minimal amounts.

Dosage and method of administration

As indicated in the instructions for use, Ersefuril is taken orally.

• Adults are prescribed 200 mg (1 capsule) 4 times a day (interval between doses is 6 hours); children aged 6 to 18 years – 200 mg (1 capsule) 3-4 times a day (interval between doses 6-8 hours); Children aged 3 to 6 years are prescribed 200 mg (1 capsule) 3 times a day (interval between doses is 8 hours).
• The duration of treatment is 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days of taking the drug, the patient should consult a doctor.

The drug should be used only according to the method of application and in the doses indicated in the instructions. If necessary, the patient should consult a doctor before using the drug.

Adverse reactions

Taking this medicine may increase symptoms of dehydration that accompany intestinal infections, so it is important to take enough fluids during treatment.

Ersefuril is well tolerated by patients and rarely causes side effects. Manifestations such as urticaria-type rashes can occur in individuals with a tendency to allergic reactions. In very rare cases (in case of intolerance to the active substance), dangerous conditions may develop - anaphylactic shock or Quincke's edema.

Overdose symptoms

Cases of overdose with Ersefuril have not been described. However, if the medicine is taken in a dosage that is excessively higher than recommended, the side effects may worsen. In such situations, symptomatic treatment is used.

special instructions

Before you start using the drug, read the special instructions:

1. Drinking alcohol during therapy with nifuroxazide is prohibited.
2. If symptoms of hypersensitivity appear (shortness of breath, skin rash, itching), you should stop taking the drug.
3. Instructions for patients with diabetes: one single dose (1 capsule) of Ersefuril contains 72 mg of sucrose, which corresponds to 0.00072 XE. The maximum daily dose (4 capsules) contains 288 mg of sucrose, which corresponds to 0.0288 XE.

When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy. In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), the patient should consult a doctor to decide on the use of systemic antibacterial drugs.

Compatibility with other drugs

If the patient is taking other medications (including over-the-counter medications), you should consult your doctor before using Ersefuril.

Ersefuril or Ercefuryl belongs to the group of intestinal antiseptics, as indicated by the instructions for use included in each package. It is used to eliminate the causes of loose stools. The generic name of the drug is Nifuroxazide, of which it is the active ingredient. How is the medicine used, what dosage is needed, and are there any contraindications?

Composition and types of the drug

This medicine has several forms of release:

• Capsules 200 mg. In some cases they are called tablets, although this is incorrect.
• Ersefuril suspension or children's syrup, 5 ml of which contains 200 mg of the active ingredient.

Ersefuril inside the capsule contains a yellow powder mixture without a distinct odor. In addition to nifuroxazide, the composition contains sugar, starch flour, and magnesium stearate. The capsule shell is made from gelatin, food additive E171, yellow dye.

The medicine in the form of a suspension contains sucrose, carbomer, methyl parahydroxybenzoate, purified water, and banana flavor.

Pharmacodynamics and pharmacokinetics

Patients are interested in what they help with and how Ersefuril tablets/suspension work. Since their main substance has antimicrobial properties, the medicine is classified as an intestinal antiseptic with an antidiarrheal effect. Nifuroxazide blocks the activity of pathogens that disrupt intestinal function, destroys their cell membranes, and reduces the production of toxins. At the same time, it does not disrupt the intestinal microflora and does not provoke the development of dysbacteriosis.

The drug is highly active against E. coli, causative agents of campylobacteriosis, shigellosis, and salmonellosis. Citrobacter and Enterobacter cloacae are weakly sensitive to nifuroxazide. Friedlander's bacillus and Pseudomonas aeruginosa exhibit resistance to antiseptics.

The medication is not absorbed into the bloodstream, remaining almost completely in the digestive tract and acting there as an antibiotic. A small portion is excreted in pure form, and the remaining portion of nifuroxazide is excreted chemically.

When is it appointed?

Ersefuril is actively used for viral intestinal poisoning. It also helps against diarrhea that occurs without a significant increase in body temperature, symptoms of intoxication, or noticeable deterioration in health. The medication is sometimes used not only for diarrhea, but also for cleansing the intestines. For this purpose, a single dose of nifuroxazide is practiced.

If an acute bacterial infection develops, the medicine is not effective. It is advisable to prescribe capsules/suspension in the absence of helminthic infestations. To do this, the patient must undergo appropriate tests.

Contraindications

The antiseptic is not used for the development of intestinal disorders if the patient has a history of the following contraindications:

• Hypersensitivity to medication ingredients that can cause serious allergic reactions.
• Children under 6 years of age (capsule form).
• The period of bearing a child.
• Congenital fructose malabsorption, lack of sucrase-isomaltase enzymes.

It is not recommended to use Ersefuril if there is a disturbance in the activity of the central nervous system, mental disorders, or brain pathologies. The medication is used with caution for gastrointestinal diseases. It does not aggravate other chronic ailments, but before starting a therapeutic course, you should inform the specialist about your medical history.

Important! In pediatrics, capsules are allowed to be taken by children over 3 years of age under the supervision of specialists. The treatment regimen and dosage here are determined by the doctor, based on the general condition, age, weight of the patient, and the severity of the pathological process.

Side effects

Side effects noted:

• Rashes, redness on the skin.
• Shortness of breath.
• Hives.
• Anaphylactic shock.
• Angioedema.

If the conditions of use are violated and the drug is not taken correctly, symptoms of intoxication may develop.

How to take Ersefuril

The patient should familiarize himself with the detailed treatment regimen for the drug so that an overdose does not occur and other undesirable consequences do not develop. The instructions for use of the capsule form of Ersefuril state that it can be taken regardless of food intake. The optimal dosage is calculated based on the patient’s full age:

• Children under 16 years of age are allowed to take Ersefuril three capsules three times a day, the interval between doses is about 6-8 hours. The maximum daily allowance is four capsules.
• Adults over 16 years of age are allowed to take four capsules four times a day with a time interval of 6 hours. The daily maximum norm is four capsules.

The duration of treatment with the drug ranges from 5-7 days. During this period, severe symptoms of diarrhea are often eliminated. If this does not happen, therapy with nifuroxazide does not give the desired effect, it is necessary to reconsider the treatment. The patient should see a doctor to decide whether to prescribe more effective medications.

For children

If indicated, pediatricians prescribe the medicine in the form of a suspension. Adult patients can also use the syrup for infectious diarrhea.

• Ersefuril for children over 2 years old is recommended to take 5 ml three times a day before or after meals.
• Orally for adults – 5 ml four times a day.

Using the drug for more than a week is unacceptable. For newborns and children under 2 years of age, the use of the suspension is contraindicated.

During pregnancy and breastfeeding

There is not enough verified information about the effects of nifuroxazide on the body during pregnancy. Therefore, the use of capsules/suspensions is not recommended during this period. If it is impossible to take other safe medications when diarrhea develops without deteriorating well-being, then the medication is used under strict medical supervision.

Important! During pregnancy, it is not recommended to self-prescribe any medications. Especially if there are symptoms of intoxication or infection. A woman should contact a gynecologist if there are any signs of discomfort.

The active ingredient can pass into breast milk, but in the case of a short course of treatment with the drug, you should not give up breastfeeding. If a full therapeutic course is ahead, then it is possible to continue breastfeeding after treatment.

Features of use

You should consult your doctor before taking this medicine. It is advisable to prescribe Ersefuril after an examination of the quantitative indicators of enzymes. If they are found to be insufficient, the doctor will prescribe another medication.

Intestinal antiseptic therapy should be carried out in conjunction with rehydration, especially in childhood. Liquid volumes that should be regularly introduced into the digestive tract depend on the age category of the patient and the severity of the pathological process. Sometimes inpatient treatment is required to fully restore the water-salt balance.

If there is a deterioration in the condition, an increase in body temperature, and the symptoms of diarrhea do not disappear, an additional examination is carried out. A specialist may prescribe stronger antimicrobial agents with other components. For infections that affect adjacent organs and tissues, it is recommended to use systemic antiseptics.

Capsules, like the suspension, do not have a negative effect on alertness and visual organs, so they can be taken when operating machinery and driving vehicles.

In case of an overdose, deterioration of health and increased symptoms of intoxication are possible. Other side effects not listed in the instructions may also occur.

Drug interactions

If the patient is taking any medications, including over-the-counter medications, he should inform the specialist before starting therapy.

Analogs

Structural analogues of the drug include:

• - a product produced in tablet form and in the form of a flavored suspension.
• Furazolidone– used for diarrhea of ​​bacterial origin. It is considered a cheaper, more accessible analogue of Ersefuril.
• Stopdiar- an analogue of the capsule form and suspension of Ersefuril, used for acute infectious diarrhea.
• Enterofuril. Indicated for infectious diarrhea, chronic colitis, enterocolitis of infectious origin. Helps cure diarrhea in children from 2 months. Available in the form of flavored syrup.

Modern pharmacies can provide patients with a wide range of antimicrobial agents to combat diarrhea. Only an experienced specialist after an examination can help you make the right choice.

Storage conditions and periods

In capsule form, the drug Ersefuril is stored in a dry room at a temperature not exceeding 35°C for no longer than five years. The suspension does not lose its qualities for three years if stored at a temperature not exceeding 30°C. Freezing the medicine is prohibited.

Diarrhea can be treated in two ways: by acting on the intestinal walls and sphincter muscles to retain feces, or by suppressing the influence of microbes and bacteria that disrupt microflora and peristalsis. Ersefuril, a drug that has a second effect, helps to quickly and effectively stop diarrhea, reduce pain and alleviate the patient’s condition.

Clinical and pharmacological group

Ersefuril is an antidiarrheal drug that belongs to the group of intestinal antiseptics. That is, it does not affect the muscles, but inhibits the activity of harmful bacteria.

Composition and release form

Ersefuril capsules are available in blister packs of 14 pieces. The gelatin shell of the capsule, like the powder inside, is yellow. One tablet contains:

• nifuroxazide – 200 mg;
• magnesium stearate – 1.8 mg;
• sucrose – 72 mg;
• corn starch – 88 mg.

This composition ensures that the capsule quickly passes through the digestive tract, being absorbed in the area of ​​the small and large intestines. According to the instructions for use, the Ersefuril tablet begins to act within 2-3 hours.

pharmachologic effect

The active substance Ersefuril affects pathogenic bacteria in the intestines, inhibiting their activity and removing them along with the feces. Thanks to the bactericidal effect of the drug, mucus and intestinal microflora are normalized, and peristalsis is stabilized.

At the same time, the tablets do not affect beneficial bacteria in the intestines, so Ersefuril does not require parallel intake of probiotics or therapeutic restoration of the body after treatment.

Indications for use

To ensure that the treatment of gastrointestinal dysfunction and subsequent diarrhea is safe and effective, when prescribing drugs, the doctor takes into account the indications for their use. Ersefuril is prescribed in case of bacterial diarrhea, which is characterized by an acute stage of progression.

Most often, Ersefuril is part of a complex treatment, although sometimes it is prescribed separately from other drugs. Only a doctor can determine the nature and extent of methods for eliminating diarrhea. Patient reviews cannot be an argument for prescribing treatment or influence it.

Dosage and duration of treatment

The daily dose of Ersefuril for the treatment of acute diarrhea in an adult should be 800 mg. That is, you need to take 1 capsule at a time. 4 times a day.

For a child from 6 to 12 years old, the norm is 600 mg of nifuroxazide, so you need to give him 1 capsule 3 times a day.

The duration of treatment is determined by the doctor based on the characteristics of the disease and test results, but according to the instructions, it should not be longer than 7 days.

Mode of application

Ersefuril capsules are intended for oral use. It should be swallowed whole with plenty of water. In this case, the drug is drunk regardless of meals.

The pharmacological effect of Ersefuril occurs within two days. If the patient does not feel better, and diarrhea continues at the same level, you should consult a doctor and adjust the treatment.

Pregnancy and lactation

During pregnancy and lactation, the use of Ersefuril is contraindicated. In exceptional cases, when the expected effect is more important than the possible consequences for the mother and fetus, capsules can be taken under the supervision of a doctor.

special instructions

To maintain water and electrolyte balance in the body during the treatment of diarrhea with Ersefuril capsules, it is worth increasing the amount of fluid consumed.

There is no information on the interaction of Ersefuril with other drugs, but to maintain the effectiveness of treatment, it is important to maintain a sufficient time interval between taking tablets.

Ersefuril has no effect on concentration and driving ability.

Contraindications

Taking into account contraindications before prescribing Ersefuril will protect the patient from possible side effects or negative consequences of treatment. Capsules are not prescribed in the following cases:

• child's age up to 6 years;
• fructose intolerance;
• increased sensitivity of the body to the components of the drug.

If any of them are present, treatment of acute diarrhea should be carried out with drugs that do not contain nifuroxazide.

Side effects

Possible consequences of treatment with Ersefuril may include minor allergic reactions, expressed in nausea and skin rash. If their degree exceeds tolerable limits, it is important to inform the doctor about this and reconsider the specifics of treatment.

Conditions for dispensing from pharmacies

Ersefuril is approved for free sale in pharmacies without a doctor's prescription.

Storage conditions and periods

Ersefuril capsules can be stored for no more than 5 years in a dry and dark place, out of reach of children. The air temperature should not exceed 30 degrees.

Trade name of the drug: Ersefuril ® .

International nonproprietary name: nifuroxazide.

Dosage form: capsules.

Compound
1 capsule contains:
active substance: nifuroxazide - 200.0 mg;
Excipients: corn starch, sucrose, magnesium stearate.

Capsule composition
body: gelatin, titanium dioxide (E171), yellow iron oxide dye (E172);
cap: gelatin, titanium dioxide (E171), yellow iron oxide dye (E172).

Description: hard gelatin capsules No. 1, consisting of a yellow body and a yellow cap. The contents of the capsules are yellow powder.

Pharmacotherapeutic group: antimicrobial agent, nitrofuran.

ATX Code: A07AX03.

Pharmacological properties
Pharmacodynamics
Nifuroxazide is an antimicrobial agent, a derivative of nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. Destroys the microbial cell membrane, reduces the production of toxins by microorganisms. Highly active in relation to Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions And Vibrio parahaemolytique, Staphylococcus spp. Poorly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.

Does not disturb the balance of intestinal microflora. In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed from the digestive tract, and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically modified.

Indications for use

Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.

Contraindications

• Hypersensitivity to nifuroxazide, nitrofuran derivatives or other components of the drug.
• Children under 3 years of age.
• Pregnancy.
• Fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the drug

Use during pregnancy and breastfeeding
Pregnancy
In animal studies, no teratogenic effect was detected. However, as a precautionary measure, taking nifuroxazide during pregnancy is not recommended (insufficient clinical experience with use during pregnancy).

Breastfeeding period
During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug. You should consult your doctor.

Directions for use and doses

Children from 3 to 6 years old: 200 mg (1 capsule) 3 times a day (interval between doses 8 hours).
Children from 6 to 18 years old: 2 00 mg (1 capsule) 3-4 times a day (interval between doses 6-8 hours).
For adults: 200 mg (1 capsule) 4 times a day (interval between doses 6 hours).
Duration of treatment: 5-7 days, but not more than 7 days.

If there is no improvement within the first 3 days of taking it, you should consult a doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Side effect

Allergic reactions (skin rash, urticaria, Quincke's edema, anaphylactic shock). If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose
Overdose symptoms are not known. Treatment is symptomatic.

Interaction with other drugs Concomitant use with drugs that cause the development of disulfiram-like reactions and drugs that inhibit the function of the central nervous system is not recommended. If you are taking other medications (including over-the-counter medications), consult your doctor before using Ersefuril ®.

special instructions
When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy. In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs. If symptoms of hypersensitivity appear (shortness of breath, skin rash, itching), you should stop taking the drug. Drinking alcohol during therapy with nifuroxazide is prohibited.

Instructions for patients with diabetes mellitus
One single dose (1 capsule) of the drug Ersefuril ® contains 72.0 mg of sucrose, which corresponds to 0.00072 Bread Unit (XU). The maximum daily dose (4 capsules) contains 288 mg of sucrose, which corresponds to 0.0288 XE.

Impact on the ability to drive vehicles and machinery
The drug Ersefuril ® does not affect the ability to drive vehicles and machines.

Release form
Capsules 200 mg.
14 capsules in a blister made of PVC/aluminum foil.
1 or 2 blisters along with instructions for use in a cardboard box.

Best before date
5 years.
Do not use the drug after the expiration date indicated on the package.

Storage conditions
Store at a temperature not exceeding 30 °C. Keep out of the reach of children.

Vacation conditions
Over the counter.

Registration Certificate Holder

SANOFI-AVENTIS FRANCE, France. SANOFI-AVENTIS FRANCE, France.

Manufacturer
Delpharm Dijon, France
Delpharm Dijon, France
6, Boulevard de G Europe, 21800, Quetigny, France.

Consumer complaints should be sent to the following address in Russia:
125009, Moscow, st. Tverskaya, 22.

Ersefuril instructions

The essence of treatment with this drug is to block the enzyme dehydrogenase. That is, substances responsible for carbohydrate and fat metabolism and oxidation in the microbial cell are inhibited. Nuforoxazide disrupts respiration, membranes, and metabolism in cells that cause intestinal infections.

Under the influence of the drug, the immune system is activated, namely, the titer of complement and phagocytosis increases. As a result, the engulfment of unwanted cells by phagocytes increases.

The effect of Ersefuril depends on the dosage. In lower dosages the effect is bacteriostatic, and in higher doses it is bactericidal. No overdose was observed.

The drug is successfully used against gram-positive and gram-negative microorganisms.

Addiction and the emergence of drug-resistant strains of bacteria do not occur. Also not developing.

Allergic reactions may occur as side effects.

Contraindications for use: hypersensitivity to the drug and its components. This drug is not recommended for persons with fructose intolerance or acute sucrase-isomaltase deficiency due to the presence of glucose in the composition.

During pregnancy, capsules are prescribed with caution. Use is permitted during breastfeeding.

Ersefuril indications

Ersefuril analogues

Nifuroxazide, Enterofuril, Ecofuril are analogues of Ersefuril.

Ersefuril price

The price range is between 150 – 288 hryvnia.

Ersefuril reviews

Claudia

I have tried many different remedies for diarrhea throughout my life. One of the most effective and safe, in my opinion, is Ersefuril. There are other good ones too. But today I keep this particular drug in my medicine cabinet. When I travel, I also don’t forget to take it with me, it can always come in handy. And we recently bought a suspension for a child, the positive thing is that there is no unpleasant taste. There are no problems with the supply of medicine and dysbiosis does not need to be treated later.