Metronidazole in the treatment of gynecological diseases. The use of metronidazole suppositories in urological practice

Anti-inflammatory drugs in the form of suppositories are prescribed for various diseases of the female reproductive system. Some gynecological suppositories are used vaginally, others rectally. But in general, the list of gynecological suppositories is very wide.

Anti-inflammatory drugs in gynecology are always prescribed if an inflammatory process is noted. They are widely used, but at the same time, like other medications, vaginal and rectal suppositories have certain disadvantages.

Suppositories as a dosage form

Suppositories – one of the best medicines that can effectively cure women’s diseases. Suppositories are used for the prevention of female diseases, as well as for their treatment. The composition includes a base, which gives the product the shape of a candle, as well as a medicinal substance. The main feature of this medicine is that its form is stored at room temperature, and turns into liquid form when body temperature is noted.

Anti-inflammatory vaginal suppositories prescribed for a variety of diseases of the female reproductive system. Vaginal suppositories are also used to prevent such diseases. In particular, vaginal suppositories are prescribed for ovarian inflammation , antiviral suppositories for women, etc.

Despite the fact that the list of vaginal suppositories is very large, their names are known to many, and in pharmacies most of these drugs are sold without a prescription, the doctor should tell you individually which antibacterial or antiviral drugs should be used.

It is very important to know how to properly administer suppositories. How to use this form of medication is indicated in the instructions. But how to place suppositories may vary depending on the drug. For example, some suppositories are recommended to be used before bedtime, once a day.

To insert candles correctly, you need to take a lying position and wash your hands first. Also, before administering the medicine, you need to prepare a sanitary pad.

All candles are usually divided into different types depending on where they are administered:

The main advantage of using this form of medication is that the active substance enters the bloodstream relatively quickly (about half after half an hour, 100% after an hour). At the same time, it does not enter the gastrointestinal tract and is not destroyed in the liver. Also, vaginal suppositories have not only a general, but also a local effect.

In addition, the application process is very simple and painless; suppositories very rarely cause allergic reactions.

Candles for colpitis

Need to know for those who are interested in what it is in gynecology, that this is a disease in which an inflammatory process occurs in the vaginal mucosa. Treatment of colpitis in women depends on which infectious agent provoked the inflammation. So, colpitis (vaginitis) can be like specific (fungal , trichomonas , gonorrheal etc.), and nonspecific (streptococcal , staphylococcal , polymicrobial ). It is depending on the type of infection that drugs for the treatment of colpitis are selected, in particular, suppositories for colpitis .

Main features vaginitis – discomfort in the area of ​​the external genitalia, a feeling of severe itching and burning. The amount of discharge with an unpleasant odor increases, the temperature may rise, pain in the lower abdomen occurs, and problems with urination appear.

In this situation, it is important to use correctly selected suppositories for vaginitis, which help not only get rid of symptoms, but also completely cure vaginitis, suppressing the activity of pathogenic microorganisms.

In the first days of illness, you need to douche using antiseptic agents (, Ppotassium manganate , Bicarbonate of soda ). Herbs are also used for this purpose - douching with chamomile, sage, lemon balm,

In parallel with douching, you can insert suppositories into the vagina. The doctor selects suppositories that demonstrate activity against the type of pathological microflora that provoked the disease. Therefore, before prescribing treatment, the gynecologist conducts a study to determine which medications should be taken.

Nonspecific vaginitis

If the patient is diagnosed nonspecific colpitis , she is prescribed broad-spectrum antibacterial vaginal suppositories or antiseptics.

The following suppositories can be prescribed to cure the inflammatory process in gynecology.

After the first stage of treatment has completed and the activity of the fungi has been suppressed, a second stage of therapy must be carried out to restore normal vaginal flora. It is important that normal conditions are created for active reproduction of lactobacilli to occur.

During this period, the woman is prescribed:

• Candles containing . The drug is intended to normalize microflora. Bifidumbacterin is used for up to 10 days, 1 supp. in a day.
• (with dried bifidobacteria) you need to use 1 supp every day. within up to 10 days.
• used for 10 days, 1 sup. Acylact for the night. Candles are also prescribed Vagilak .
• The drug contains lactobacilli, 1 capsule is administered into the vagina. morning and evening, treatment lasts up to 10 days.
• You can also use during treatment, Bificol , in ampoules. The contents of the ampoules must be diluted with water and tampons with this liquid should be inserted intravaginally.

Anti-inflammatory suppositories in gynecology

Currently, the list of names of drugs with anti-inflammatory effects is very large. Such drugs are used to treat inflammation, as additional means in a treatment regimen, which also includes tablets, injections, herbs, etc. All names of suppositories for inflammation that are offered in pharmacies must be reported to the doctor so that he can prescribe the most effective treatment.

Often, as part of a comprehensive treatment regimen, they are also present in gynecology. Antibacterial drugs effectively complement local medications in the form of suppositories.

Ichthyol suppositories in gynecology

Despite the simplicity of this natural-based drug, reviews of in gynecology, they are almost always positive, since it works effectively. The active substance is ichthyol.

These analgesic suppositories are used if treatment of inflammatory diseases is necessary, as well as to accelerate the healing of injuries and ulcers of the mucous membrane. Medicines containing ichthyol are suitable for both women and men (rectally).

If necessary, they are also used in veterinary medicine - for the treatment of dogs.

Methyluracil suppositories in gynecology

They are used to treat a variety of gynecological diseases. They accelerate epithelial renewal, heal damaged skin, and stimulate metabolic processes. They produce an anti-inflammatory effect and are used as an additional remedy in the treatment of cervical erosion.

Sea buckthorn suppositories in gynecology

Sea buckthorn suppositories are widely used in gynecology.

It is advisable to use them in the treatment, mucosal injuries , at dysbacteriosis . Reviews indicate that suppositories with sea buckthorn are very effective in gynecology. Moreover, they can be used at any age - old age or too young age is not a contraindication. Treatment with this drug during pregnancy is also allowed.

Candles with calendula

When choosing antimicrobial drugs, one should not forget about candles with calendula . After all, calendula has an antimicrobial, anti-inflammatory, and wound-healing effect. The instructions indicate that this dosage form rarely causes side effects.

Vaginal suppositories are used to treat inflammatory processes, atrophic colpitis, and cervical erosion.

Indomethacin suppositories in gynecology

This medicine, by blocking the synthesis of prostaglandins, relieves pain, reduces temperature, and relieves inflammation. They are prescribed for inflammation of the ovaries, and for pain.

Also Indomethacin suppositories effective in reducing the formation of adhesions.

Candles Betiol

In gynecology, suppositories containing belladonna and ichthammol are used as an antiseptic. They are used rectally for... But sometimes during pregnancy planning, the doctor prescribes suppositories, which include belladonna, in order to influence the basal temperature.

Syntomycin suppositories

used if the pelvic organs are affected by staphylococci, chlamydia, streptococci and other bacteria.

They are prescribed when vaginitis etc. Syntomycin has virtually no systemic effect on the body. Sintomycin is administered intravaginally twice a day. How long to use the drug is determined by the doctor, but, as a rule, treatment lasts up to 10 days.

Candles Kyzyl-May

The composition includes herbs, sea buckthorn oil, cocoa butter, bentonite, beeswax. Candles improve tissue regeneration and have an anti-inflammatory effect.

Prescribed when colpitis , cervitis , erosions . You need to apply 1-2 supp rectally. per day, treatment lasts up to 15 days. Cost – from 600 rubles.

Suppositories for adnexitis, endometriosis

The instructions for many drugs in the form of suppositories indicate the names of female gynecological diseases. After all, antibiotics for gynecological diseases in the form of tablets, as well as injections, must be supplemented with local agents.

Treatment should be carried out according to the scheme prescribed by the specialist. It is important that antibiotics for adnexitis are selected correctly. After all, inflammatory diseases of the reproductive system can provoke specific ( chlamydia , gonorrhea , trichomoniasis ) and nonspecific microorganisms.

• Adnexit – inflammation of the appendages, in which a woman feels pain in the groin area. The pain can be cutting, dull, aching.
• – an inflammatory process of the uterus, in which pain of a different nature is noted in the lower abdomen. Most often, this disease develops after intrauterine interventions ( curettage , operative delivery).

As in adnexitis , and with endometritis The woman’s body temperature may rise and other signs of intoxication may occur.

At endometriosis Medicines aimed at restoring immune status are often used. How to treat endometriosis - with medications or other methods - the doctor determines after examination and establishing an accurate diagnosis. Treatment of endometriosis involves the use of the drug with interferon and vitamin E and C. Rectal suppositories are used for pain relief - NSAIDs .

The drug is used to resolve adhesions. Candles Terrylitin and others are prescribed to reduce inflammatory processes. It is also sometimes advisable to take tablets - Chimes and etc.

Treatment of inflammation of the uterus and appendages involves, first of all, antibiotics; suppositories are also used for inflammation of the female organs. The use of suppositories is practiced for different purposes.

Rectal suppositories for inflammation of the appendages with an anti-inflammatory effect usually contain NSAIDs. They provide anti-inflammatory, antipyretic and analgesic effects. Medicines that belong to the group of NSAIDs suppress the synthesis of prostaglandins, which are formed in large quantities during inflammatory processes and provoke pain.

The use of rectal suppositories begins at the same time as the patient begins taking antibiotics. Treatment lasts from 7 to 10 days. As a rule, it is prescribed Movalis , and etc.

• Prescribed once, it should be used in the evening.
• Movalis (active component meloxicam ) apply once before bedtime, 7 days.
• Voltaren apply in the evening and in the morning.
• Diclofenac , Diklovit - once a day.
• Candles with belladonna – 1-3 times a day.
• Flexen , Flamax (active component ketoprofen) is used once for 7 days. The name "Alamaks" is also found. However, the correct name for the candles is not Alamax, but Flamax.

Modern gynecology offers a fairly wide list of rectal anti-inflammatory suppositories, but any painkillers and anti-inflammatory suppositories should be prescribed by a doctor as part of the general treatment regimen. If additional painkillers in tablets are needed, this should also be selected by a specialist.

Also, anti-inflammatory suppositories for women with endometritis and adnexitis are prescribed intravaginally. Like anti-inflammatory rectal suppositories, they need to be used regularly. The purpose of using such drugs is to sanitize the vagina and suppress anaerobic flora.

Prescribed for such diseases Terzhinan And Fluomizin (active ingredient metronidazole). You need to use Terzhinan and Fluomizin for up to 10 days, 1-2 supp. every day.

When the main therapy with anti-inflammatory drugs is completed, it is very important to normalize the vaginal biocenosis. For this purpose, they use both those drugs that contain bifidobacteria and lactobacilli, as well as Longidaza suppositories.

Longidaza provides a proteolytic effect. These are effective preventive suppositories, as they prevent the appearance of adhesions and also resolve existing ones. Longidaza stabilizes the function of the immune system and also provides antioxidant and anti-inflammatory effects. This drug is also prescribed for ovarian cysts. The suppositories should be used rectally, before bedtime. The course of therapy lasts up to 3 weeks.

Suppositories for cervical erosion

– a very common disease among women. It develops if the stratified squamous epithelium in the vaginal part of the cervix is ​​desquamated. In its place, columnar epithelial cells that line the cervical canal multiply. Ectopic cervix is a more correct name for this disease.

For those who are looking for names of candles from cervical erosion , it should be noted that the treatment of this disease is carried out as follows: the pathological area is destroyed by electrical, chemical, and laser methods. Before and after cauterization, suppositories are prescribed to treat cervical erosion. Before cauterization with laser, radio waves or other methods, 5-7 days before the procedure, you need to place anti-inflammatory suppositories to prevent Revitaxa – phytocandles, which also include. They effectively relieve inflammation and promote healing.

You can purchase both expensive drugs and their cheaper analogues. Candles with reparative properties are used in 1 pc. for 10-14 days.

If necessary, tablets and other medications are also prescribed.

For cystitis

Women suffering from this use different medications in this form. Almost every thematic forum informs about this, where women often describe the means they use. However, any medicines for cystitis should be taken after they have been prescribed by medical specialists, despite the fact that they can often be bought in pharmacies without a prescription. Suppositories are prescribed as an aid in treatment. As a rule, the doctor prescribes broad-spectrum antibiotics, which are used for infectious diseases.

Most often, suppositories are prescribed for cystitis. Hexicon (contains chlorhexidine, which is an antiseptic), Betadine , Genferon , McMirror , Syntomycin suppositories , Candles with Palin and etc.

conclusions

In modern medicine there is a large number of drugs in this form. Their use allows you to quickly and effectively cure various diseases of the female reproductive system. A number of the drugs described above are also used for menopause. But every woman should understand that the most effective and rapid treatment will be if, after establishing a diagnosis, a treatment regimen is prescribed by a gynecologist.

Name:

Metronidazole (Metronidazolum)

Pharmacological
action:

Antiprotozoal and antimicrobial drug, a 5-nitroimidazole derivative.
Mechanism of action consists in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active regarding:
- Trichomonas vaginalis,
- Entamoeba histolytica,
- Gardnerella vaginalis,
- Giardia intestinalis,
- Lamblia spp.,
- as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Eubacter spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.).
IPC for these strains it is 0.125-6.25 μg/ml.
In combination with amoxicillin is active against Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole). Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics that are effective against common aerobes. Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, and stimulates reparative processes.

Indications for
application:

Protozoal infections: extraintestinal amebiasis, including amoebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis, giardiasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomonas urethritis.
Infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system, incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis.
Infections caused by Clostridium spp.., Peptococcus and Peptostreptococcus: abdominal infections (peritonitis, liver abscess), pelvic infections (endometritis, fallopian tube and ovarian abscess, vaginal vault infections).
Pseudomembranous colitis(associated with the use of antibiotics). Gastritis or duodenal ulcer associated with Helicobacter pylori.
Prevention of postoperative complications(especially interventions on the colon, perirectal area, appendectomy, gynecological operations).
Radiation therapy for patients with tumors- as a radiosensitizing drug in cases where tumor resistance is due to hypoxia in tumor cells.

Mode of application:

Powder for the preparation of solution for intravenous administration, solution for infusion, suspension for oral administration, tablets, vaginal tablets, film-coated tablets:

Orally and parenterally. Orally, during or after meals (or with milk), without chewing.
For trichomoniasis- 250 mg 2 times a day for 10 days or 400 mg 2 times a day for 5-8 days. Women must additionally be prescribed metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g/day. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests. Alternative scheme therapy is to prescribe 2 g once to the patient and his sexual partner.
Children 2-5 years old- 250 mg/day; 5-10 years - 250-375 mg/day, over 10 years - 500 mg/day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.
For giardiasis- 500 mg 2 times a day for 5-7 days. Children under 1 year- 125 mg/day, 2-4 years - 250 mg/day, 5-8 years - 375 mg/day, over 8 years - 500 mg/day (in 2 doses). The course of treatment is 5 days.
With giardiasis- 15 mg/kg/day in 3 divided doses for 5 days. For adults: for asymptomatic amebiasis (if a cyst is detected), the daily dose is 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.
For chronic amoebiasis daily dose - 1.5 g in 3 divided doses for 5-10 days, for acute amoebic dysentery - 2.25 g in 3 divided doses until symptoms stop.
For liver abscess the maximum daily dose is 2.5 g in 1 or 2-3 doses, for 3-5 days, in combination with antibiotics (tetracyclines) and other methods of therapy. Children 1-3 years old- 1/4 adult dose, 3-7 years- 1/3 dose for an adult, 7-10 years - 1/2 dose for an adult.
For balantidiasis- 750 mg 3 times a day for 5-6 days. For ulcerative stomatitis, adults are prescribed 500 mg 2 times a day for 3-5 days; In this case, the drug is not indicated for children.
For pseudomembranous colitis- 500 mg 3-4 times a day. For eradication of Helicobacter pylori - 500 mg 3 times a day for 7 days (as part of combination therapy, for example, a combination with amoxicillin 2.25 g/day).
When treating anaerobic infection the maximum daily dose is 1.5-2 g.
In the treatment of chronic alcoholism Prescribe 500 mg/day for a period of up to 6 (not more than) months.
To prevent infectious complications - 750-1500 mg/day in 3 divided doses 3-4 days before surgery or 1 g once on the first day after surgery. 1-2 days after surgery (when oral administration is already allowed) - 750 mg/day for 7 days.
In case of severe renal dysfunction(CC less than 10 ml/min) the daily dose should be reduced by 2 times. Suspension for oral administration.
Anaerobic bacterial infections: children - 7 mg/kg every 8 hours, course of treatment - 7-10 days;
giardiasis: children 2-5 years old - 200 mg/day, 5-10 years old - 300 mg/day, 10-15 years old - 400 mg/day. The duration of treatment for giardiasis is 5 days. The course of treatment can be repeated after 10-15 days Parenterally. For adults and children over 12 years of age, an initial dose of 0.5-1 g IV drip (infusion duration is 30-40 minutes), and then every 8 hours, 500 mg at a rate of 5 ml/min. If well tolerated, after the first 2-3 infusions they switch to jet administration. The course of treatment is 7 days. If necessary, intravenous administration is continued for a longer time. The maximum daily dose is 4 g. According to indications, switch to maintenance oral administration at a dose of 400 mg 3 times a day. Children under 12 years of age are prescribed according to the same regimen in a single dose - 7.5 mg/kg.
For purulent-septic diseases usually carry out 1 course of treatment. For preventive purposes, adults and children over 12 years of age are prescribed 0.5-1 g intravenously on the eve of surgery, on the day of surgery and the next day - 1.5 g / day (500 mg every 8 hours). After 1-2 days, they switch to maintenance therapy orally. For patients with chronic renal failure and creatinine clearance less than 30 ml/min and/or liver failure, the maximum daily dose is no more than 1 g, the frequency of administration is 2 times a day.
As a radiosensitizing drug administered intravenously at a rate of 160 mg/kg or 4-6 g/sq.m of body surface 0.5-1 hour before the start of irradiation. Apply before each irradiation session for 1-2 weeks. During the remaining period of radiation treatment, metronidazole is not used. The maximum single dose should not exceed 10 g, course dose - 60 g. To relieve intoxication caused by radiation, drip administration of a 5% dextrose solution, Hemodez or 0.9% NaCl solution is used.
For cancer of the cervix and uterine body, skin cancer is used in the form of local applications (3 g dissolved in a 10% DMSO solution), moisten tampons that are used topically 1.5-2 hours before irradiation).
In case of poor tumor regression, applications carried out throughout the course of radiation therapy. If the dynamics of tumor cleansing from necrosis is positive - during the first 2 weeks of treatment.

Vaginal gel, vaginal suppositories, vaginal tablets:
Intravaginally, once 2 g or as a course of treatment 500 mg/day 2 times a day (morning and evening) for 10 days. During the course of treatment, sexual intercourse should be avoided.

Gel for external use, cream for external use:
Apply a thin layer to previously cleansed skin 2 times a day, morning and evening, for 3-9 weeks. If necessary, apply an occlusive dressing. Application of cream and gel can be alternated. The average duration of treatment is 3-4 months, the therapeutic effect is usually observed after 3 weeks of treatment.

Side effects:

From the gastrointestinal tract: diarrhea, loss of appetite, nausea, vomiting, intestinal colic, constipation, unpleasant “metallic” taste and dry mouth, glossitis, stomatitis, pancreatitis.

From the nervous system and sensory organs: headache, dizziness, impaired coordination of movements, syncope, ataxia, confusion, irritability, depression, increased excitability, weakness, insomnia, hallucinations; with long-term therapy in high doses - peripheral neuropathy, transient epileptiform seizures.

From the genitourinary system: dysuria, cystitis, polyuria, urinary incontinence.

Allergic reactions: urticaria, skin rash, skin flushing, nasal congestion, fever.

Others: arthralgia, flattening of the T wave on the ECG; with long-term therapy in high doses - leukopenia, candidiasis.

Local reactions: with intravenous administration - thrombophlebitis (pain, hyperemia or swelling at the injection site). When used intravaginally - itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge without odor or with a faint odor, frequent urination; after discontinuation of the drug, vaginal candidiasis may develop; a burning sensation or irritation of the penis in a sexual partner. When used externally - hyperemia, peeling and burning of the skin, lacrimation (if the gel is applied close to the eyes).

Contraindications:

Hypersensitivity, leukopenia(including a history), organic lesions of the central nervous system (including epilepsy), liver failure (in case of high doses), pregnancy (first trimester), lactation period. With caution. Pregnancy (II-III trimesters), renal/liver failure.

Interaction
other medicinal
by other means:

Strengthens the effect of indirect anticoagulants, which leads to an increase in the time of prothrombin formation. Similar to disulfiram causes intolerance ethanol. Concomitant use with disulfiram can lead to the development of various neurological symptoms (the interval between prescriptions is at least 2 weeks). Metronidazole for intravenous administration is not recommended to be mixed with other drugs. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects. The simultaneous administration of drugs that stimulate microsomal oxidation enzymes in the liver (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, resulting in a decrease in its plasma concentration. When taken simultaneously with Li+ drugs, the concentration of the latter in the plasma may increase and the development of symptoms of intoxication. It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamides enhance the antimicrobial effect of metronidazole.

Cream for external use,
- vaginal gel,
- vaginal suppositories,
- vaginal tablets,
- powder for preparing a solution for intravenous administration,
- solution for infusion,
- suspension for oral administration,
- pills,
- film-coated tablets.

Storage conditions:

List B. In a place protected from light.

1-(b-Hoxyethyl)-2-methyl-5-nitroimidazole.
Metronidazole is a white or slightly greenish crystalline powder. Slightly soluble in water, slightly soluble in alcohol.
Pills contain 0.25 and 0.5 g of metronidazole.
Vaginal suppositories contain 0.5 g of metronidazole.
100 ml solution contain:
metronidazole - 0.5g;
Excipients: sodium chloride, ethylenediaminetetraacetic acid disodium salt, water for injection.

As you know, a woman’s vaginal microflora consists of lactobacilli. As a result of the occurrence of a disease such as bacterial vaginitis, the number of these lactobacilli is significantly reduced, which leads to disruption of the normal internal environment of the vagina.

Scientists have proven that metronidazole suppositories are better and more effective than using gels. For a quick recovery, it is recommended to use not only metronidazole suppositories, but also nystatin suppositories. Suppositories with metronidazole and nystatin are used for 7-10 days.

Interesting! Suppositories are more effective than gels due to the fact that they contain a larger amount of active substance.

Indications for use

Metronidazole suppositories, instructions for use of which are provided below, are considered a broad-spectrum agent. This medicine should be used if the following diseases exist:

• giardiasis;
• inflammation of the inner lining of the heart;
• amoebiasis;
• accumulation of purulent discharge in organs;
• thrush;
• chronic alcoholism;
• liver abscess;
• disease of the genitourinary system due to various infections;
• sepsis and peritonitis.

This drug can also be used as a prophylaxis before complex manipulations in gynecology or before certain surgical interventions.

The gel is also very popular in the treatment of infectious diseases. For inflammation, infection in the oral cavity and for various dental procedures, Metrogyl gel is an effective remedy. In addition, ointment with the active ingredient metronidazole is recommended for use by those people who have skin problems. It helps with rashes on the face.

Metronidazole suppositories are very popular in gynecology. One suppository of the drug contains 500 mg of active substance. This medication is used to treat pathologies such as:

• urethritis;
• vaginitis;
• urogenital trichomoniasis.

Interesting! According to patient reviews, after two days a positive result from treatment with metronidazole suppositories is visible.

What does the drug consist of?

The composition of the active component in the drug is of two types: 500 mg and 250 mg of the active substance Metronidazole. In appearance, the suppository resembles the shape of a rocket with a rounded end. The color of the substance is more like white or white with a yellowish tint.

When using the drug, pharmacokinetics is that only a small part of the drug is absorbed into the body (within 20%). When using tablets, this figure is higher. Metronidazole is excreted from the body within eleven hours through urine and feces.

Metronidazole suppositories, instructions for use

The course of treatment with the drug ranges from one week to ten days. One suppository is inserted into the vagina before bed in case of bacterial vaginosis. If the patient is being treated for trichomonas vaginitis, then suppositories are used twice a day - morning and evening. It is recommended to repeat the course of treatment after one and a half months.

Important! To obtain a stronger effect, it is recommended to use metronidazole tablets together with suppositories.

Using scissors, you need to cut the packaging and remove the suppository. Then, with clean hands, carefully insert the suppository deep into the vagina. Treatment should be started at the beginning of the menstrual cycle for greater effect.

In addition, during the treatment period it is not recommended to use an additional method of self-medication in the form of douching with various solutions or drugs. And in order for the treatment to give a positive result, doctors do not recommend sexual intercourse while using medications.

If the patient is diagnosed with a liver abscess, then the dosage and method of using the drug differ from the previous ones. In this case, it is recommended to consume 2.5 g per day for five days. In the treatment of chronic alcoholism, the drug is prescribed according to the following principle:

• A suppository is used twice a day (one suppository in the morning and one in the evening);
• chronic alcoholism can be treated with this medication for six months;
• If during treatment problems arise with the normal functioning of the kidneys, the dosage of the drug is reduced. In this case, it is recommended to use one candle per day (preferably at night).

Can metronidazole be used during menstruation or rectally? Treatment of infectious diseases is thus irrational and useless. Metronidazole during menstruation has no effect on the infection at all.

Since the drug can cross the placenta, it is not recommended for use during pregnancy. Only in extreme cases is it prescribed in the third trimester of pregnancy. In addition, metronidazole passes into breast milk, so the use of this drug is prohibited during breastfeeding. In case of treatment with metronidazole, breastfeeding should be stopped.

Side effects of the drug

Since metronidazole suppositories are considered to be of synthetic origin, before using them you need to read the full list of contraindications and side effects. Therefore, before starting treatment, it is recommended to consult a specialized doctor.

For example, metronidazole may cause adverse reactions to the digestive system. In this case, the patient may feel nauseated and may vomit even after taking the drug once. If the patient does not tolerate the drug, he may experience severe pain and cramps in the intestinal area, as well as possible constipation or diarrhea.

Adverse reactions to the drug that may occur as a result of its use:

• allergic reaction in the form of rash, itching and redness of the skin;
• urine may change to a brownish-reddish color;
• headaches and dizziness;
• convulsions;
• There are rare cases of neutropenia or pancytopenia;
• encephalopathy;
• rare cases of hallucinations and mental disorders;
• myopia;
• diplopia.

Contraindications to the drug

There are certain contraindications to the use of medications such as metronidazole suppositories. The main ones are:

• organic negative effects of the nervous system;
• blood disease;
• beginning of pregnancy (first trimester);
• hypersensitivity to the active substance;
• improper functioning of the liver;
• renal and liver failure (allowed only under medical supervision and with extreme caution).

Important! The dosage is prescribed by the doctor for each patient individually. Changing it yourself can lead to negative consequences!

Analogues of the drug Metronidazole

The modern pharmacological industry has developed several analogues of metronidazole, the composition of which is practically no different from the original. Metronidazole suppositories, just like their analogues, have their own side effects. The main analogues include:

• Trihapol;
• Metromicon-Neo;
• Nikamed;
• Metrophyte;
• Miconazole;
• Klean;
• Metrogil;
• Flagin.

If the doctor prescribes weaker analogues, he recommends taking iodoxide as a supplement. But to be on the safe side, iodoxide is prescribed by a specialized doctor when taking metronidazole and its strong analogues. After all, iodoxide is an antimicrobial drug that effectively destroys fungus or microbes in the body.

How much does this medication cost? The drug Metronidazole costs an average of 200 rubles. But you can find its analogues with similar composition and indications, but at a lower price.

But it is not recommended to make a decision on purchasing analogues on your own. After all, any medicinal substance that includes metronidazole is synthetic, and therefore can cause various allergic reactions. Therefore, before purchasing, you need to consult with a specialized doctor who will select the most effective and safe drug.

Any infectious inflammation of the genital tract must be treated promptly. One of the effective remedies for such problems is Metronidazole suppositories. Their active ingredient of the same name has a broad antibacterial and antimicrobial effect, allowing you to get rid of most pathogenic microorganisms. Metronidazole disrupts the metabolism of cells that cause vaginal infections, which causes their death.

Application in gynecology

Women are most susceptible to genital tract infections, because not only sexual intercourse, but also various medical interventions can become a source of infection. And the need for a speedy recovery among the fair half is much higher. To prevent the risk of complications, including infertility, you need to follow all the recommendations of your doctor and follow the prescribed Metronidazole treatment regimen. The instructions for use of the drug contain recommended doses, but it is the doctor who adjusts the treatment according to the tests performed and the nature of the disease.

Metronidazole is available in various forms, but in gynecology the most popular are those that act locally: suppositories and creams. Each suppository contains 125, 250 or 500 mg of active ingredient and auxiliary components (semi-synthetic glycerides, solid fat, etc.).

Metronidazole suppositories suppress Trichomonas, gram-negative anaerobes and anaerobic streptococcus, some gram-positive bacteria, and Candida fungus.

• urogenital form of trichomoniasis;
• urethritis of varying severity;
• thrush;
• vaginitis, including nonspecific;
• nonspecific bacterial vaginosis.

More than 300 pharmaceutical companies around the world produce metronidazole. In Russia, it is included in the list of vital and essential drugs that are subject to price restrictions. Therefore, the medicine is quite affordable, which is especially important for people with a small family budget.

Method of treatment

The drug in the form of suppositories is inserted deep into the vagina. Its advantage over Metronidazole tablets is its rapid local effect. This form is the safest: the medicine does not enter the bloodstream. After administration, it is recommended to take a supine position for 30-60 minutes.

Already after the first time of using candles, a pronounced effect appears. The course lasts 7-10 days, but the exact period is determined by the gynecologist.

When treating with metronidazole in gynecology, alcohol consumption is completely excluded. This is because the interaction of metronidazole and alcohol can lead to an Antabuse-like effect, when symptoms of alcohol poisoning rapidly develop. During therapy, sexual activity is also excluded.

To prevent re-infection, treatment should be carried out on both sexual partners.

Treatment should not be interrupted if it seems that the visible symptoms have disappeared and the desired result has been achieved. In this case, symptoms of vaginal candidiasis may appear.

After the course of therapy, you need to take tests again. Only if a positive result is obtained can we speak of a complete recovery.

Side effects

Metronidazole suppositories are extremely rare, but side effects may still be present:

• allergic skin rashes and urticaria;
• itching and burning on the mucous membranes;
• pain in the area of ​​the external genitalia;
• frequent urination;
• migraine, dizziness, insomnia;
• change in taste, metallic taste in the mouth;
• nausea, vomiting, loss of appetite;
• bowel movement disorders (diarrhea, constipation);
• intestinal spasms;
• blood diseases in which the level of leukocytes is reduced.

If these side effects occur, you should report them to your doctor. He, in turn, can change the drug to another. You should not try to replace the medication yourself.

The instructions for use provide a complete list of contraindications, including individual intolerance to the drug, epilepsy, problems with the central nervous system, serious kidney and liver diseases, reduced levels of leukocytes in the blood, the first trimester of pregnancy and lactation. In the second and third trimester, the use of metronidazole is strictly adjusted by a doctor and carried out under his supervision.

Judging by the reviews of women who have used vaginal suppositories, Metronidazole is very effective in treating sensitive genital tract infections.

After a few days of use, the discharge and itching stop, and a full course of complex therapy completely cures the disease, even in severe form.

Metronidazole suppositories are an antimicrobial and antiprotozoal agent that has an antibacterial effect, is of synthetic (artificial) origin, and belongs to the group of drugs that are derivatives of nitromidazole.

The drug is used for vaginal administration, and is available in the form of suppositories in two concentrations of the potent main substance: 250 mg (10 suppositories per package) and 500 mg (10 suppositories per package). Each candle is packed in a contour cassette, in appearance it has an elongated shape, white or slightly yellowish.

It is necessary to understand what are the indications for use in gynecology, and what use do suppositories involve? And also consider similar metronidazole-based products, and study doctors’ reviews of this product.

Composition, indications for use

Suppositories with metronidazole, in addition to the active substance, additionally contain polyethylene oxide (1500) and polyethylene oxide (400). The drug shows high activity in the treatment of gardnerellosis, trichomoniasis and other diseases.

Local application kills bacteria (Gram-positive, and also overwhelmingly anaerobic) and fungi (including those that cause diseases such as candidiasis). When using the product, the susceptibility of some neoplasms in the human body to radiation increases, and processes of a reparative nature are stimulated.

When administering suppositories, only a small part of the potent element can be absorbed. A pronounced local effect is revealed. Only a small concentration of the administered drug can be detected in the patient’s blood.

Part of the drug is transformed into metabolites, which are excreted through the liver and kidneys. The maximum content of the drug in the body is observed five hours after taking the drug.

The instructions for use present the following situations when it is advisable to prescribe this drug:

During gynecological surgical interventions, Metronidazole suppositories can be prescribed as a preventive measure to prevent infectious pathologies.

It is worth noting that the drug is produced by more than 300 pharmaceutical companies. In Russia, the drug is included in the list of vital drugs, and it has a limited price.

Therefore, everyone can buy the medicine, and this will not require excessive financial investments.

Contraindications and side effects

Having found out what this drug is for, it is necessary to consider in what situations it is not recommended, and also find out the likely adverse reactions from using the drug.

It is known that any medication has its contraindications, and suppositories are no exception to this rule. Contraindications must be taken into account before prescribing a topical medication.

Reviews from doctors show that the active component of the drug can penetrate the placental barrier, and therefore reach the child, so they try not to prescribe it during pregnancy. However, it may be recommended after the 3rd month of pregnancy if the mother's life is in danger.

When a medicine is prescribed during lactation, the woman is advised to stop breastfeeding for the period of therapy. Studies have shown that the drug is able to pass into breast milk.

The following situations are also contraindications for use:

1. Hypersensitivity to the product or its auxiliary components.
2. Impaired liver function.
3. Diseases of the circulatory system (for example, leukopenia).
4. Organic disorder of the central nervous system.

With extreme caution and under the supervision of the treating doctor, suppositories are prescribed for liver and kidney failure.

It is necessary to use suppositories only in the dosage recommended by the doctor. If you independently reduce the dose or frequency of administration, the medicine will not give the required therapeutic effect, and if you increase it, an overdose occurs.

Possible adverse reactions to the topical drug:

• Neutropenia.
• Allergic reactions with skin manifestations (redness and peeling of the skin, itching, burning). Anaphylactic shock and pustular reflux (very rare).
• Headaches, dizziness, musculoskeletal disorders, convulsions, tremors of the limbs.
• Mental disorders.
• Impaired liver function, jaundice.
• Changes in quality indicators of the liver.
• Change in urine color to dark brown.

If suppositories are used for too long a period of time, the development of fungi in the vagina cannot be ruled out, which in turn requires the appointment of an antifungal agent for treatment.

When a patient takes a prescribed drug without following the doctor’s recommendations, an overdose of the drug is detected, characterized by increased side effects. In this case, symptomatic treatment and supportive care are prescribed.

Instructions for use of candles

When the drug is prescribed during pregnancy or breastfeeding, the dosage of the drug is adjusted by about a third of the traditional dose. And only if the therapeutic effect is insufficient and according to direct indications, the doctor can increase it.

During treatment, it is necessary to stop drinking alcoholic beverages, since ethanol increases the risk of side effects - nausea, vomiting, disruption of the gastrointestinal and digestive tract. In addition, during the period of therapy, it is advisable to refrain from driving cars and vehicles.

The instructions for Metronidazole suppositories are as follows:

1. As a rule, one suppository is prescribed immediately before bedtime.
2. The duration of therapy is one and a half weeks.
3. If the therapeutic effect is insufficient, the course of treatment can be repeated after one or one and a half months.
4. Before inserting suppositories, intimate hygiene procedures are performed; suppositories are administered in a lying position.
5. In severe cases of the disease, the doctor may recommend a combination of suppositories and tablets with the substance metronidazole.

If for any reason the patient cannot carry out treatment immediately before bedtime, then the introduction of suppositories during the daytime requires being in a horizontal position for at least one hour.

It is worth noting that if sulfonamides are taken simultaneously with Metronidazole, the antimicrobial effect is enhanced. Metronidazole is not compatible with Disulfiram; such a symbiosis leads to symptoms of damage to the central nervous system.

Many patients are concerned about the question, how much does the product cost? As mentioned above, the drug is affordable for everyone, and the price of Metronidazole suppositories ranges from 70 to 90 rubles.

Analogues of candles

Today, the pharmaceutical industry provides the following similar products in the form of suppositories, which are direct analogues of Metronidazole - Trichopolum, Ginalgin, Flagyl.

Suppositories are widely used in gynecological practice, prescribed for the treatment of fungal and bacterial infections of the genitals and vagina, and can also be recommended for mixed infectious diseases.

How to use Metromicon-Neo suppositories correctly:

• Before inserting the candle, hygiene procedures are carried out and hands are treated.
• The suppository is inserted deep into the vagina.
• Usually one suppository per day is prescribed.
• The duration of therapy depends on the disease and the severity of the clinical picture of the pathology.

Absolute contraindications are the first three months of pregnancy, the period of breastfeeding, the virginity of the patient; use is also prohibited before the age of 18.

It is prescribed with extreme caution for blood diseases, diabetes mellitus, blood circulation disorders, pathologies of the central nervous system, and impaired liver and kidney function. The price of the product varies from 350 to 400 rubles.

Features of the use of Trichopolum suppositories:

1. The duration of therapy is 10 days, one suppository is administered per day.
2. The course of treatment begins immediately after the end of the menstrual cycle.

Suppositories can cause a burning sensation in the vaginal mucosa. The drug is not prescribed in the first trimester of pregnancy or during lactation. The cost of the product is in the range of 300-350 rubles.

Ginalgin suppositories have antibacterial, antifungal, antiprotozoal and bactericidal effects and have a wide spectrum of action. Prescribe one suppository per day, duration of therapy is 7-10 days.

Ginalgin is not recommended if you are intolerant to the drug, as well as with a history of the following pathologies: organic disorders of the central nervous system, blood diseases, musculoskeletal disorders, pregnancy and lactation. Cost 300-310 rubles.

Flagyl is a medicinal drug with antibacterial and antiprotozoal action. One suppository contains 500 mg of metronidazole and fat. Usually one suppository is prescribed per day; in case of liver failure, suppositories may be recommended every other day. Price 800-900 rubles.

As the review shows, Metronidazole in the form of suppositories, as well as its analogues, have their own indications and side effects, and in some situations their use poses a health hazard. Therefore, before using suppositories, it is advisable to consult a doctor.

The doctor will talk about the properties of Metronidazole suppositories and its analogues in the video in this article.