Veroshpiron tablets: instructions for use. Veroshpiron - indications for use and important features of the diuretic The drug veroshpiron

Content

With the development of edema and hypokalemia, doctors prescribe Veroshpiron - the instructions for use of the drug contain information about its penetration into the blood and urine, toxicity, methods of administration, and options for use. The medication is a diuretic, available in two formats, and is available from pharmacies with a prescription. Read the instructions for its use.

Medicine Veroshpiron

According to the pharmacological classification, the drug is a potassium-sparing diuretic. Veroshpiron can be prescribed only according to indications - the instructions for use indicate possible negative side effects and overdose if the prescribed recommendations are not followed. The medication has a pronounced diuretic effect and eliminates swelling.

Composition and release form

Veroshpiron capsules and tablets are produced. The active substance in both formulations is spironolactone. Detailed composition of the diuretic drug:

	Pills	Capsules No. 3	Capsules No. 0
Spironolactone concentration per 1 piece, mg
Additional components	Magnesium stearate, lactose monohydrate, talc, colloidal silicon dioxide, corn starch	Lactose monohydrate, sodium lauryl sulfate, corn starch, magnesium stearate. The capsule consists of gelatin, the cap is colored with quinoline yellow dye and titanium dioxide, the body is colored with titanium dioxide	Equal to capsule No. 3. The lid is painted with “sunset yellow” dye, the body is painted with quinoline yellow
Description	White, flat, round, chamfered	Hard gelatin, opaque yellow cap and white body, fine powdery white granules inside	Hard gelatin, opaque orange cap and yellow body, contents same as capsule no. 3
Package	20 pieces in a blister and a cardboard box	10 pieces in a blister, 3 blisters in a cardboard box

Pharmacodynamics and pharmacokinetics

The active substance spironolactone, according to the instructions, is a component that acts opposite to the adrenal hormone aldosterone. Acts in the kidney department - nephron, eliminates fluid and sodium retention, suppresses the potassium-removing effect. Spironolactone interferes with the production of kidney tubular enzymes. By binding to receptors, it increases the excretion of sodium and chlorine ions with water and urine, reduces the loss of potassium ions, and reduces the acidity of urine. According to doctors, it has a hypotensive effect due to the diuretic properties of the hormone aldosterone.

After administration, it is completely absorbed from the gastrointestinal tract, bioavailability is 100%, consumption of food increases it to the maximum. Spironolactone reaches its highest concentration 2-6 hours after morning administration. The substance binds to plasma proteins by 98%, penetrates poorly into organs and tissues, but metabolites are able to cross the placental barrier and enter breast milk.

The main metabolite of spironolactone is canrenone, and alpha-thiomethylspironolactone is also formed. They bind to plasma proteins up to 90%, reaching maximum concentrations after 2-4 hours. Substances are excreted by the kidneys and intestines. In liver cirrhosis and heart failure, the half-life of metabolites increases without signs of cumulation (accumulation).

What are Veroshpiron tablets for?

According to the instructions for use, Veroshpiron is prescribed to patients for the following indications:

essential hypertension (included in combination treatment);
edema syndrome coupled with chronic heart failure;
secondary hyperaldosteronism and conditions in which it can be detected - liver cirrhosis, ascites, edema, nephrotic syndrome;
hypokalemia or hypomagnesemia;
primary hyperaldosteronism or Conn's syndrome.

How to take Veroshpiron

Instructions for use of the drug Veroshpiron says that his should be taken orally during meals with a glass of water. Do not chew or crush tablet capsules. The optimal time to take it is in the morning and afternoon; before going to bed, the drug can interfere with falling asleep. Depending on the disease, the daily dosage for adults varies:

for essential hypertension – 50-100 mg once, can be increased to 200 mg;
with severe hyperaldosteronism, hypokalemia – 300 mg (maximum 400) in 2-3 doses, with improvement it is reduced to 25 mg/day;
for idiopathic hyperaldosteronism – 100-400 mg/day;
diagnosis and treatment of primary hyperaldosteronism - 400 mg/day for four days with a short test and for 2-3 weeks with a long test;
for hypokalemia or hypomagnesemia – 25-100 mg/day once, the maximum dose is 400 mg in several doses;
short course of preoperative therapy for primary hyperaldosteronism – 100-400 mg in 1-4 doses.

For swelling

For the treatment of edema, the dosage changes in accordance with the disease against which they arose:

nephrotic syndrome – 100-200 mg;
chronic heart failure - daily 100-200 mg 3 times a day for five days in combination with loop or thiazide-type diuretics, with improvement, the dose is reduced to 25 mg, the maximum is 200 mg;
liver cirrhosis - 100 mg with an equal ratio of sodium and potassium ions in the urine, with another - 200-400 mg.

Duration of treatment

The duration of therapy with Veroshpiron depends on the diagnosis of the patient and the severity of his condition. Doctors recommend treating essential arterial hypertension for at least 14 days, and once a positive effect is achieved, gradually reduce the dose. The maintenance dosage will be about 25 mg/day, the duration will depend on the patient’s condition and will be prescribed by the treating doctor.

How to take before or after meals

According to the instructions, using Veroshpiron with food increases its absorption in the gastrointestinal tract, so it is better to take the drug during or immediately after meals. If you miss or delay a dose for a period of no more than four hours, you should immediately take the missed capsule. Otherwise, take your regular dose at your next scheduled appointment. When treating with medication, you should not consume too much salt and foods rich in potassium (apricots, tomatoes, peaches, coconuts). Dates, oranges, bananas, and alcohol are prohibited.

special instructions

In the instructions for use of the medicine there is a special instructions section where Recommendations and important information for patients:

During treatment of edema, the level of urea nitrogen in the blood serum may temporarily increase, causing the development of reversible metabolic acidosis.
Elderly patients, people with kidney disease, liver disease should regularly monitor blood electrolytes and kidney function.
Veroshpiron does not directly affect carbohydrate metabolism, but in diabetic nephropathy and diabetes mellitus it should be taken with caution.
At the initial stage of treatment with spironolactone, it is prohibited to drive vehicles or operate mechanisms that require concentration due to inhibition of psychomotor reactions.

During pregnancy

According to the instructions, the use of Veroshpiron during pregnancy and breastfeeding is contraindicated. If a doctor prescribes a drug to a woman during lactation, breastfeeding should be stopped. The use of Veroshpiron for weight loss is strictly contraindicated. The drug has a diuretic effect, causing dehydration of the body when consumed without reason.

In childhood

The instructions state that The use of the drug is permitted for children aged three years and older. For the treatment of edema, an initial dose of 1-1.3 mg/kg body weight is prescribed. After five days, the dosage is adjusted and, if necessary, tripled. During maintenance therapy in combination with other diuretics, the dose is reduced to 1-2 mg/kg. Until the age of five, the child takes crushed tablets dissolved in the form of a suspension, after this age - capsules.

Drug interactions

The instructions say that the use of Veroshpiron may affect the effectiveness of other medications:

reduces the effect of anticoagulants, coumarin, heparin, and the toxicity of cardiac glycosides;
increases the toxicity of digoxin and lithium due to decreased clearance;
enhances the metabolism of carbenoxolone, which ensures sodium retention;
increases the effect of furosemide and antihypertensive drugs;
potassium preparations, potassium supplements, aldosterone effect blockers, potassium-sparing diuretics increase the risk of developing hyperkalemia;
salicylates reduce the diuretic effect;
taking ammonium chloride, cholestyramine together with Veroshpiron develops metabolic acidosis;
Fludrocortisone increases tubular secretion of potassium.

Side effects and overdose

The following side effects may occur when taking this medication: described in the instructions:

diarrhea, vomiting, gastritis, bleeding in the stomach, nausea;
intestinal colic, constipation, abdominal pain;
menstrual irregularities, breast pain;
allergic reactions, urticaria, skin rash, itching, fever;
acute renal failure, convulsions, muscle spasms.

Symptoms of overdose when using the drug are nausea, decreased blood pressure, and diarrhea. The patient experiences muscle weakness, dry mouth, and severe thirst. Gastric lavage and symptomatic treatment of dehydration and hypotension will help eliminate the symptoms. The water-electrolyte balance is normalized with diuretics to remove potassium and parenteral administration of dextrose with insulin. Severe cases require hemodialysis.

Contraindications

According to the instructions, the drug is taken with caution in case of hypercalcemia, diabetes mellitus, chronic renal failure, metabolic acidosis; under the supervision of a doctor - for diabetic nephropathy, surgical operations, anesthesia, menstrual irregularities. The use of the medicine is prohibited in the presence of the following contraindications:

severe hyperkalemia or hyponatremia;
anuria;
Addison's disease;
breastfeeding and pregnancy;
severe renal failure;
children's age up to three years (for tablets) and up to five years (for capsules);
lactose intolerance, galactose and glucose malabsorption syndrome, lactase deficiency;
hypersensitivity to components.

Terms of sale and storage

You can buy the drug in pharmacies with a prescription. It is stored away from light and children at temperatures up to 30 degrees. The shelf life is five years.

Analogue of Veroshpiron

According to the active substances in the composition and pharmacological effects, the following are distinguished: analogues of the drug in the form of capsules and tablets, produced by Russian and foreign manufacturers:

Verospilactone;
Spironolactone;
Aldactone;
Vero-spironolactone;
Decriz;
Inspra;
Renial;
Epplepres;
Eplerenone;
Epletor;
Eridanus;
Espiro.

Price

To purchase the drug you will need a prescription. The cost in an online pharmacy or a regular department will depend on the type of medicine purchased and the level of trade markup. Approximate prices are listed below.

Potassium-sparing diuretic, competitive aldosterone antagonist
Drug: VEROSHPIRON
Active substance of the drug: spironolactone
ATX coding: C03DA01
KFG: Potassium-sparing diuretic
Registration number: P No. 011953/01
Registration date: 02.09.05
Owner reg. cert.: GEDEON RICHTER Ltd. (Hungary)

Veroshpiron release form, drug packaging and composition.

Tablets are white or almost white, round, flat, beveled, with a characteristic mercaptan odor, marked “VEROSPIRON” on one side.
1 tab.
spironolactone
25 mg

Excipients: colloidal silicon dioxide, magnesium stearate, talc, corn starch, lactose monohydrate.

20 pcs. - blisters (1) - cardboard packs.

Hard gelatin capsules, size No. 3, with an opaque yellow cap and an opaque white body.
1 caps.
spironolactone
50 mg

Ingredients of the gelatin capsule: quinoline yellow (E104) C.I.47005, titanium dioxide (E171) C.I.77891, gelatin.

Hard gelatin capsules, size No. 0, with an opaque orange cap and an opaque yellow body.
1 caps.
spironolactone
100 mg

Excipients: sodium lauryl sulfate, magnesium stearate, corn starch, lactose monohydrate.

Composition of the gelatin capsule: orange dye (E110) C.I.15985, titanium dioxide (E171) C.I.77891, quinoline yellow (E104) C.I.47005, gelatin.

10 pieces. - blisters (3) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action of Veroshpiron

Potassium-sparing diuretic, competitive aldosterone antagonist.

In the distal parts of the nephron, spironolactone prevents the retention of sodium and water by aldosterone and suppresses the potassium-removing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent area of the collecting ducts and distal tubules. By binding to aldosterone receptors, it increases the excretion of sodium, chlorine and water ions in the urine, reduces the excretion of potassium and urea ions, and reduces the acidity of urine.

The maximum effect is observed 7 hours after taking the capsules orally and lasts for at least 24 hours. The hypotensive effect is due to the diuretic effect, which is not constant. The diuretic effect appears on days 2-5 of treatment.

Pharmacokinetics of the drug.

Suction

After oral administration, it is quickly and completely absorbed from the gastrointestinal tract; bioavailability is 100%. After daily administration of 100 mg of spironolactone for 15 days, Cmax is 80 ng/ml, the time to reach Cmax after the next morning dose is 2-6 hours.

Distribution

Binds to plasma proteins by 98%.

Spironolactone penetrates poorly into organs and tissues, while spironolactone itself and its metabolites penetrate the placental barrier, and canrenone passes into breast milk. Vd - 0.05 l/kg.

Metabolism

During the biotransformation process in the liver, active sulfur-containing metabolites 7-alpha-thiomethylspironolactone and canrenone are formed. Canrenone reaches its Cmax after 2-4 hours, its binding to plasma proteins is 90%.

Removal

T1/2 - 13-24 hours. Excreted mainly in urine (50% in the form of metabolites, 10% unchanged) and partially in feces. Canrenone excretion (mainly in the urine) is biphasic, T1/2 in the first phase is 2-3 hours, in the second - 12-96 hours.

Pharmacokinetics of the drug.

in special clinical cases

In liver cirrhosis and heart failure, the duration of T1/2 increases without signs of cumulation, the likelihood of which is higher in chronic renal failure and hyperkalemia.

Indications for use:

Essential hypertension (as part of combination therapy);

Edema syndrome in chronic heart failure (can be used as monotherapy and in combination with standard therapy);

Conditions in which secondary hyperaldosteronism may be detected, incl. liver cirrhosis, accompanied by ascites and/or edema, nephrotic syndrome and other conditions accompanied by edema;

Hypokalemia/hypomagnesemia (as an adjuvant for its prevention during treatment with diuretics and when it is impossible to use other methods of correcting potassium levels);

Primary hyperaldosteronism (Conn's syndrome) - for a short preoperative course of treatment;

To establish the diagnosis of primary hyperaldosteronism.

Dosage and method of administration of the drug.

For essential hypertension, the daily dose for adults is usually 50-100 mg once and can be increased to 200 mg, and the dose should be increased gradually, once every 2 weeks. To achieve an adequate response to therapy, the drug must be taken for at least 2 weeks. If necessary, adjust the dose.

For idiopathic hyperaldosteronism, the drug is prescribed at a dose of 100-400 mg/day.

For severe hyperaldosteronism and hypokalemia, the daily dose is 300 mg (maximum 400 mg) in 2-3 doses; as the condition improves, the dose is gradually reduced to 25 mg/day.

For hypokalemia and/or hypomagnesemia caused by diuretic therapy, Veroshpiron is prescribed at a dose of 25-100 mg/day, once or in several doses. The maximum daily dose is 400 mg if oral potassium supplements or other methods of replenishing potassium deficiency are ineffective.

When diagnosing and treating primary hyperaldosteronism, Veroshpiron is prescribed as a diagnostic tool for a short diagnostic test for 4 days at 400 mg/day, dividing the daily dose into several doses per day. If the concentration of potassium in the blood increases while taking the drug and decreases after its discontinuation, the presence of primary hyperaldosteronism can be assumed. For a long-term diagnostic test, the drug is prescribed in the same dose for 3-4 weeks. When correction of hypokalemia and arterial hypertension is achieved, the presence of primary hyperaldosteronism can be assumed.

After the diagnosis of hyperaldosteronism is established using more accurate diagnostic methods, as a short course of preoperative therapy for primary hyperaldosteronism, Veroshpiron should be taken in a daily dose of 100-400 mg, divided into 1-4 doses during the entire period of preparation for surgery. If surgery is not indicated, then Veroshpiron is used for long-term maintenance therapy, using the lowest effective dose, which is selected individually for each patient.

When treating edema due to nephrotic syndrome, the daily dose for adults is usually 100-200 mg. No effect of spironolactone on the underlying pathological process has been identified and therefore the use of this drug is recommended only in cases where other types of therapy are ineffective.

In case of edema syndrome against the background of chronic heart failure, the drug is prescribed daily for 5 days, 100-200 mg/day in 2-3 doses, in combination with a loop or thiazide diuretic. Depending on the effect, the daily dose is reduced to 25 mg. The maintenance dose is selected individually. The maximum daily dose is 200 mg.

For edema due to liver cirrhosis, the daily dose of Veroshpiron for adults is usually 100 mg if the ratio of sodium and potassium ions (Na+/K+) in the urine exceeds 1.0. If the ratio is less than 1.0, then the daily dose is usually 200-400 mg. The maintenance dose is selected individually.

For edema in children, the initial dose is 1-3.3 mg/kg body weight or 30-90 mg/m2/day in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased by 3 times compared to the original.

Side effects of Veroshpiron:

From the digestive system: nausea, vomiting, diarrhea, ulceration and bleeding from the gastrointestinal tract, gastritis, intestinal colic, abdominal pain, constipation, impaired liver function.

From the central nervous system and peripheral nervous system: ataxia, lethargy, dizziness, headache, drowsiness, lethargy, confusion, muscle spasms, cramps of the calf muscles.

From the hematopoietic system: agranulocytosis, thrombocytopenia, megaloblastosis.

Metabolic: hyperuricemia, hypercreatininemia, increased urea concentration, hyperkalemia, hyponatremia, metabolic hyperchloremic acidosis or alkalosis.

From the endocrine system: deepening of the voice, in men - gynecomastia (the likelihood of development depends on the dose, duration of treatment and is usually reversible), decreased potency and erection; in women - menstrual irregularities, dysmenorrhea, amenorrhea, metrorrhagia during menopause, hirsutism, pain in the mammary glands, breast carcinoma (no connection with taking the drug has been established).

Allergic reactions: urticaria, rarely - maculopapular and erythematous rash, drug fever, itching.

Dermatological reactions: alopecia, hypertrichosis.

From the urinary system: acute renal failure.

Contraindications to the drug:

Addison's disease;

Hyperkalemia;

Hyponatremia;

Severe renal failure (creatinine clearance less than 10 ml/min);

Pregnancy;

Lactation period;

Hypersensitivity to any of the components of the drug.

The drug should be prescribed with caution in case of hypercalcemia, metabolic acidosis, AV block (hyperkalemia contributes to its intensification), diabetes mellitus (with confirmed or suspected chronic renal failure), diabetic nephropathy, surgical interventions, taking medications that cause gynecomastia, local and general anesthesia, menstrual irregularities, breast enlargement, liver failure, liver cirrhosis, as well as elderly patients.

Use during pregnancy and lactation.

The use of Veroshpiron is contraindicated during pregnancy and lactation.

Special instructions for the use of Veroshpiron.

When using Veroshpiron, a temporary increase in the level of urea nitrogen in the blood serum is possible, especially with reduced renal function and hyperkalemia. It is also possible to develop hyperchloremic metabolic acidosis. When prescribing Veroshpiron to patients with impaired renal and liver function, and elderly patients, regular monitoring of serum electrolytes and renal function is necessary.

Taking Veroshpiron makes it difficult to determine the concentration of digoxin, cortisol and adrenaline in the blood.

Despite the absence of a direct effect on carbohydrate metabolism, the presence of diabetes mellitus, especially with diabetic nephropathy, requires special caution when prescribing Veroshpiron due to the possibility of developing hyperkalemia.

When treating NSAIDs while taking Veroshpiron, kidney function and blood electrolyte levels should be monitored.

During treatment with Veroshpiron, alcohol consumption is contraindicated, and food rich in potassium should be avoided.

Impact on the ability to drive vehicles and operate machinery

During the initial period of treatment, it is prohibited to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions. The duration of restrictions is set individually.

Drug overdose:

Symptoms: nausea, vomiting, dizziness, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry mouth, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.

Treatment: gastric lavage, symptomatic treatment of dehydration and arterial hypotension. In case of hyperkalemia, it is necessary to normalize water-electrolyte metabolism with the help of potassium-removing diuretics, rapid parenteral administration of a dextrose solution (5-20% solutions) with insulin at the rate of 0.25-0.5 units per 1 g of dextrose; if necessary, dextrose can be reintroduced. In severe cases, hemodialysis is performed.

Interaction of Veroshpiron with other drugs.

Veroshpiron, when used simultaneously, reduces the effect of anticoagulants (heparin, coumarin derivatives, indandione) and mitotane; enhances the effect of diuretics and antihypertensive drugs, enhances the effect of triptorelin, buserelin, gonadorelin.

When taking Veroshpiron simultaneously with potassium preparations, potassium supplements and potassium-sparing diuretics, ACE inhibitors, angiotensin II antagonists, the risk of developing hyperkalemia increases.

With the use of Veroshpiron, the toxicity of cardiac glycosides decreases (since normalizing the level of potassium in the blood prevents the development of toxicity).

Veroshpiron reduces the sensitivity of blood vessels to norepinephrine (requires caution during anesthesia).

"Loop" and thiazide diuretics enhance and accelerate the diuretic and natriuretic effects of Veroshpiron.

GCS also enhance the diuretic and natriuretic effect of Veroshpiron in hypoalbuminemia and/or hyponatremia.

Salicylates and indomethacin reduce the diuretic effect of Veroshpiron.

Ammonium chloride and cholestyramine, when used simultaneously with Veroshpiron, promote the development of hyperkalemic metabolic acidosis, and fludrocortisone causes a paradoxical increase in tubular secretion of potassium.

With simultaneous use, Veroshpiron increases the toxic effect of lithium due to a decrease in its clearance.

Veroshpiron, when used simultaneously, increases the metabolism of phenazone (antipyrine), increases the half-life of digoxin (digoxin intoxication is possible), accelerates the metabolism and excretion of carbenoxolone. Carbenoxolone promotes sodium retention by spironolactone.

Terms of sale in pharmacies.

The drug is available with a prescription.

Terms of storage conditions for the drug Veroshpiron.

The drug should be stored out of the reach of children at a temperature of 15° to 30°C. Shelf life: 5 years.

Veroshpiron is a high-quality diuretic drug that compares favorably with other diuretics in its effect on the level of potassium in the body. Mechanism of action: spironolactone (the active compound of the drug) affects the adrenal cortex, thereby blocking the hormone aldosterone, which is responsible for removing potassium from the body during water retention. Potassium remains in the body, while water is excreted with sodium and chlorine. After entering the body, it is absorbed into the gastrointestinal tract. The drug is excreted from the body through urine and feces.

The drug is marketed in the form of capsules and tablets.

What does Veroshpiron help with?

The medicine is not dispensed without a doctor's prescription. Typically, this diuretic is prescribed to eliminate edema and reduce blood pressure in heart failure. The drug may also be prescribed to identify problems associated with increased activity of the adrenal cortex (hyperfunction). The drug is also actively used if there is a need to remove excess sodium or chlorine ions from the body. In combination, it can be prescribed for essential hypertension as a drug that improves blood circulation and thereby lowers blood pressure. If surgery is planned for Conn's Syndrome, the drug may be prescribed for several days before surgery.

How and how much to take

If you are using the drug to relieve swelling due to disorders of the cardiovascular, renal and other systems, then Veroshpiron should be taken from 110 to 190 mg per day for adults. Children at least three years old should take the drug at a rate of 1.1-3.2 mg/kg body. After approximately five days, the dosage should be adjusted, coordinating it with the result.

In case of treatment of problems with the adrenal glands with the drug, 390 mg per day is prescribed three to four times a day for four days. Approximately the same dosage of the drug is prescribed in case of testing for hyperaldosteronism. In such cases, the medicine should be taken for about 20-30 days.

If the drug is used to normalize the ionic balance, possibly disturbed by other diuretics, then the medicine should be taken from 30 to 90 mg/day. If hypokalemia is clearly visible, the initial dose is prescribed at 300 mg/day. Guided by further analyses, the dosage is slowly reduced.

The daily dose of Veroshpiron should not exceed 400 mg.

In what cases should you refrain from taking

The drug is inappropriate for excess potassium, lack of sodium, Addison's disease, kidney problems, allergies, pregnancy and breastfeeding.

You should think carefully before taking the drug:

for diabetes
for general and local anesthesia
for liver damage associated with cirrhosis
for irregular menstruation
old people

If the drug cannot be discontinued if you are breastfeeding, you should stop breastfeeding.

Side effects

The drug is often well tolerated by humans; side effects are observed in case of overdose. In case of an overdose, a person may experience dizziness, an allergic reaction, arrhythmia, nausea and vomiting, dry mouth, thirst, and weakness. In case of poisoning, perform gastric lavage.

We hope that we have helped you with this article. We hope that you understand what Veroshpiron is and why it is taken. We wish you good health.

otchego.net

"Veroshpiron" - a diuretic or not? "Veroshpiron": reviews

Taking antihypertensive drugs in most cases is due to deterioration in health, poor diet and old age, which causes hypertension. In our time, hypertension is called a “slow killer”: it wears out blood vessels and the heart gradually, without causing harm with sudden attacks, with the exception of hypertensive crises. Diuretic tablets "Veroshpiron" are a popular solution for reducing the volume of circulating fluid. But is it safe to take them?

Blood pressure concept

Blood pressure, hereinafter referred to as blood pressure, is one of the main vital indicators, due to the need to transport blood through vessels to organs and tissues. Probably everyone knows that there is “upper” and “lower” pressure: these two numbers, measured with a tonometer, characterize blood pressure at two points.

The first, systolic, at the moment of ejection of blood by the heart. The second, diastolic, at the moment of relaxation of the heart muscle. How does the drug “Veroshpiron” help in adjusting blood pressure? Is this a diuretic or not? Let's figure it out.

Group of antihypertensive drugs

Drugs that affect the innervation of the heart and blood vessels. The contraction of the heart muscle and blood vessels can be regulated. More precisely, innervation can be regulated. Take, for example, the well-known “white coat hypertension”, when patients show higher indicators when they see doctors: by worrying, they (the patients) thereby “inflate” their indicators. Anti-anxiety medications can reduce blood pressure by eliminating stress-induced vasodilation.
Diuretics. Diuretic tablets "Veroshpiron" (reviews of the effectiveness of this drug can be found on many forums) are a typical representative of diuretic drugs. The action of the drug is aimed at reducing the volume of circulating fluid, which is the direct cause of the decrease in pressure.

"Veroshpiron" (diuretic): reviews, description of the drug and active substance

The active ingredient of the drug "Veroshpiron" is spironolactone. This substance is also found in medicinal analogues of “Veroshpiron”: “Spirix”, “Uractone”, “Aldactone”. There are also a number of drugs based on spironolactone against hair loss.

Preparations containing spironolactone, in addition to arterial hypertension, are used against a fairly wide range of diseases. These include, for example, edema syndrome in heart failure. For "Veroshpiron", a diuretic, reviews and ratings from doctors in the treatment of such diseases are quite favorable. Systematic treatment with drugs of this group has a positive effect on the dynamics of blood pressure, and also helps eliminate the phenomenon of swelling by reducing the volume of extracellular fluid. In addition, a group of these diuretics may be effective in the event of development of resistance (immunity) to other diuretics (Furosemide, for example).

"Veroshpiron" - a diuretic or not? Hormonal aspects of drug use

It is known that, in addition to therapeutic use, spironolactone is also used in trichological practice. The effectiveness of the active substance as an antiandrogenic is known and proven. That is, an antagonist of the male sex hormone aldosterone. But in undesirable cases, the drug also has a feminizing effect on the body. The main effect of the drug "Veroshpiron" is diuretic. But the side effect is hormonal. Patients with gynecomastia – enlarged mammary glands – were especially surprised. It should be borne in mind that the drug affects the endocrinological functions of the body, and in order to avoid side effects it should be taken with caution.

Practice of using "Veroshpiron"

"Veroshpiron" is a drug found in all therapeutic departments of the country. Most doctors keep the drug as a “battery” in case of ascites and edema of unknown origin. However, the drug is contraindicated for people with weakened kidneys and liver, as it puts additional stress on these organs. Also, due to the hormonal effects of the drug, people with menstrual irregularities are not recommended to use veroshpiron. The diuretic drug, however, is compatible with most foods and does not require a special diet. Not recommended for use by pregnant and lactating women, since hormonal changes can adversely affect the development of the fetus (in pregnant women). In nursing women, it is possible for the drug to enter the baby's body through milk.

In resolving the issue: “Is Veroshpiron a diuretic or not?” You can definitely come to an answer based on the Register of Medicines. According to him, the drug is a diuretic. The hormonal effect of the drug is considered in the context of side effects. However, spironolactone is currently undergoing a new wave of clinical trials in the field of cosmetology and dermatology.

Spironolactone: prospects for using the substance

What is the drug based on spironolactone, “Veroshpiron”? Is this remedy a diuretic or not? Or maybe hormonal?

The drug affects many functions in our body indiscriminately and, in addition to lowering blood pressure, can cause erectile dysfunction. The hormonal effects of this drug are used by many for other purposes. Persons wishing to improve the appearance of their hair or feminize the body (improved hair appearance, smooth skin, breast enlargement) often use this drug uncontrolled. In the near future, it is planned to release Veroshpiron exclusively by prescription in order to protect people from its uncontrolled use.

fb.ru

Veroshpiron

Veroshpiron is a diuretic drug that is used to eliminate various edema. The medicine belongs to the group of potassium-sparing diuretics. The active substance is spironolactone, after which the drug is called Spironolactone on the international pharmacological market.

Veroshpiron is available in the following dosage forms:

Tablets containing the substance 25 mg;
Hard gelatin capsules of 50 and 100 mg.

Pharmacological properties of Veroshpiron

According to the instructions, Veroshpiron is a competitive antagonist of the mineralocorticoid aldosterone, a special hormone produced by the adrenal cortex. The medicine produces a pronounced diuretic effect, but does not significantly affect renal blood circulation and the functioning of the renal tubules, and does not disrupt the acid-base state in the body.

After oral administration, the medicine is completely and quickly absorbed from the gastrointestinal tract. The bioavailability of Veroshpiron, according to the instructions, reaches almost 100 percent, and food intake makes this figure maximum. The highest content of the drug in the blood is 80 ng/ml, subject to daily use of a dose of 100 mg for two weeks. After the next dose in the morning, Cmax is observed after 2-6 hours.

The drug binds to blood proteins by 98 percent. The active component spironolactone penetrates tissues and organs poorly, however, it has the ability to penetrate the placental barrier in its original form and in the form of metabolites. The drug is also found in mother's breast milk.

The half-life of Veroshpiron, according to the instructions, is 13-24 hours. For the most part, the drug is excreted in the urine - 50% of the dose taken in the form of metabolites and unchanged - 10%. Minor excretion occurs through the intestines. Canrenone (the active metabolite of spironolactone) leaves the body in two stages: within 2-3 hours after administration - half and within 12-96 - the remaining amount.

In heart failure and liver cirrhosis, the half-life of Veroshpiron increases without signs of accumulation, the risk of which is higher with hyperkalemia and renal failure.

Indications for use

Indications for Veroshpiron are the following diseases:

Ascites associated with liver cirrhosis;
Edema caused by diseases of the heart and endocrine system: chronic heart failure, hirsutism, Conn's disease, polycystic ovary syndrome;
Arterial hypertension;
Severe burns;
swelling of the brain;
Diseases accompanied by edema of various origins;
Myasthenia;
Paroxysmal paralysis associated with calcium deficiency.

Directions for use and dosage

The indications for Veroshpiron described above are only guidelines, therefore treatment with this drug is prescribed only by a doctor.

For liver cirrhosis, the dosage of the drug is 0.1, 0.2 or 0.4 g per day and depends directly on the stage and characteristics of the course of the disease.

For nephrotic syndrome, the use of Veroshpiron involves doses of 0.1 to 0.2 g per day. To treat edema syndrome, it is recommended to take the medicine at a dose of 100-200 mg in three doses. According to the instructions, Veroshpiron should be taken every day for 5 days, after which the daily dosage is gradually reduced to 25 mg or increased to 400 mg in 4 doses.

To reduce high blood pressure, doses of the drug range from 50 to 100 mg per day, and the medicine is taken either once a day or in 4 divided doses. The course of treatment lasts 2 weeks. Reviews of Veroshpiron confirm that the drug is allowed to be combined with antihypertensive drugs.

For hypokalemia, the use of Veroshpiron is indicated in an amount of 25-100 mg at a time or up to 400 mg per day, divided into several doses.

Doses of the drug for primary hyperaldosteronism are 0.1, 0.2 or 0.4 mg per day, divided into 4 doses - before surgery and 25-50 mg - for long-term treatment.

To eliminate polycystic ovary syndrome and hirsutism, the dose of Veroshpiron is 100 mg 2 times a day.

Children are prescribed 1-3.3 mg per kg of weight, and this amount is taken either fractionally (4 doses) or once. After 4 days of treatment, the dose is adjusted, and it can be increased threefold. When a clinical effect is achieved, the dosage is reduced to 25 mg per day, after which the drug is taken 1 tablet 4 times a day every 4 days.

Side effects

According to reviews of Veroshpiron, the following disorders in the body are possible:

From the peripheral and central nervous system: lethargy, headaches and dizziness, ataxia, lethargy, drowsiness, confusion;
From the gastrointestinal tract: diarrhea, gastritis, nausea and vomiting, the appearance of ulcers and bleeding in the gastrointestinal tract, constipation, abdominal pain, impaired liver function;
From the hematopoietic organs: thrombocytopenia, agranulocytosis and megaloblastosis;
Metabolism: hypercreatininemia, metabolic hyperchloremic acidosis, alkalosis, hyperuricemia, increased urea concentration, hyponatremia, hyperkalemia;
From the endocrine system: gynecomastia in men (the phenomenon is reversible, quickly disappears when the drug is discontinued, in isolated cases the mammary gland may be slightly enlarged), deepening of the voice, decreased erection and potency; in women: dysmenorrhea, menstrual irregularities, pain in the mammary glands, hirsutism, metrorrhagia during menopause, amenorrhea;
Allergic reactions: itching, drug fever, rash, urticaria, maculopapular and erythematous rash (rare);
Dermatological disorders: hypertrichosis, alopecia;
From the excretory system: acute renal failure;
From the musculoskeletal system: cramps of the calf muscles, muscle spasms.

Overdose of Veroshpiron

It is extremely rare that reviews of Veroshpiron indicate cases of drug overdose. However, in such situations, you need to rinse the stomach, drink plenty of fluids, as well as caffeine in order to increase blood pressure. Patients with hyperkalemia are prescribed insulin and dextrose.

Contraindications to the use of Veroshpiron

Contraindications to Veroshpiron are:

Renal dysfunction;
Hypersensitivity to any component;
Diabetes mellitus with complications;
Addison's disease;
Increased levels of calcium and potassium in the blood;
Pregnancy;
Liver failure;
Gynecological diseases.

Veroshpiron is prescribed cautiously for conduction blockades in the heart muscle, taking hormonal medications, surgical interventions, and in elderly patients.

During treatment with this drug, you should limit the intake of potassium into the body, as well as monitor your blood condition and kidney function.

Conditions and shelf life

zdorovi.net

The drug "Veroshpiron": from what

The article describes the use of the drug "Veroshpiron", for which it is not recommended to take it. It also contains information about contraindications and side effects.

annotation

Many patients are concerned about the question, what is Veroshpiron used for? It turns out that the list of uses for this diuretic potassium-sparing agent is quite wide. The main active ingredient is Spironolactone, and the medication is produced in the form of capsules and film-coated tablets.

The drug "Veroshpiron": what is it used for?

The main purposes of the drug are:

Polycystic ovary syndrome, premenstrual syndrome, hirsutism
Diagnosis of hyperaldosteronism
Myasthenia (auxiliary drug)
Aldosterone-producing adrenal adenoma
Arterial hypertension
Primary hyperaldosteronism
Hypokalemia
Edema syndrome, nephrotic syndrome, liver cirrhosis, edema during pregnancy

Contraindications to the use of the drug "Veroshpiron"

It is prohibited to prescribe medication for a diagnosis of:

Addison's disease
hyperkalemia,
Hypersensitivity,
hypercalcemia,
anuria,
hyponatremia,
metabolic acidosis,
pregnancy (first trimester),
diabetic nephropathy,
enlargement of the mammary glands,
liver failure,
diabetes,
menstrual irregularities

Prescribed with caution in case of AV block (possibility of intensification due to the development of hyperkalemia), decompensated cirrhosis of the liver, surgical interventions, taking drugs that cause gynecomastia in old age.

Veroshpiron is a potassium-sparing diuretic of synthetic origin, used in medical practice to establish water and electrolyte balance in the human body.

The main active, potent component of the drug is spironolactone. The tablets contain 25 mg of the active element, and the capsules contain 50 and 100 mg of the active substance.

Mechanism of action

The medicine realizes its diuretic and hypotensive properties due to a specific connection with aldosterone; it blocks its actions due to interaction with hormone receptors. Aldosterone is a hormone produced by the adrenal cortex.

Features of the drug Veroshpiron:

A diuretic has a main effect - it removes excess water from the body, that is, it has a diuretic property.
The peculiarity of the medicine, which is a distinctive feature from other diuretic drugs, is that it does not help reduce potassium, but, on the contrary, helps its accumulation in the body.
This is precisely the reason why this diuretic belongs to the category of potassium-sparing tablets.
However, the medicine removes sodium and chlorine from the human body, like other diuretics.

Many patients are interested in how long it takes to wait for the diuretic effect? As a rule, the tablets begin to act actively after 3-4 days of regular use, then the pronounced hypotensive effects of the drug occur, therefore, blood pressure decreases.

It is worth noting that the diuretic acts in the skin, hair follicles, sebaceous and sweat glands, thereby helping to reduce the rate of processing of the male hormone - testosterone.

Spironolactone is completely absorbed in the gastrointestinal tract, where it binds to blood proteins, turning into metabolites (they can pass into breast milk).

The active substance spironolactone is excreted 60% from the body in the urine, and 40% during bowel movements.

Indications for use

Having found out the mechanism of action of the drug, it is necessary to understand when and in what situations it is recommended?

The instructions for use of the tablets state that the drug is suitable for many pathologies characterized by water retention in the human body.

In particular, the medicine can be used as monotherapy or combination treatment in the following situations:

For edema due to chronic heart failure.
For the treatment of edema due to liver cirrhosis and nephrotic syndrome.
And also for edema of various etiologies.
Hyperaldosteronism is a disease in which the adrenal cortex synthesizes excessive amounts of aldosterone.
Primary hypertension. In combination with other tablets, the diuretic effectively lowers blood pressure and helps stabilize it at the required level.

In addition, this drug is successfully used in gynecological practice. The instructions for use of Veroshpiron state that it can be recommended for such diagnoses as polycystic ovary syndrome and menstrual irregularities.

Sometimes it is justified to prescribe for the treatment of infertility, which is caused by excessive concentrations of the male sex hormone. Due to this property, the list of indications for use includes the following situations:

Active hair growth on the skin of women.
Cosmetic problems - oily skin, pimples, blackheads, hair loss, and other defects that are caused by high testosterone levels in women.

Reviews from patients state that this drug is better tolerated compared to similar drugs, there is no need to wait long for the effect, it quickly reduces blood pressure and helps stabilize it at the target level.

Instructions for use of the medicine

It was clarified how the medicine works and what effect it has, and also clarified the situations when its prescription is justified. Then you need to find out how to take the pills correctly, and how long to wait for the effect in a given situation?

There is no single correct and ideal dosage that is suitable for the treatment of each disease. As a rule, only the attending doctor recommends the dosage and frequency of administration, taking into account the stage and severity of the disease, the patient’s age group, concomitant pathologies, etc.

Since Veroshpiron is a diuretic drug, it is not recommended for children under 3 years of age. Instructions for use of Veroshpiron:

When diagnosed with liver cirrhosis, the starting dosage is from 100 to 400 mg per day. The dose is always based on the severity of the disease.
When diagnosing nephrotic syndrome, tablets are recommended at a dose of 100-200 mg per day.
For edema of various origins, the initial dose is 100 mg. If the effect of therapy is not enough, then the dosage is increased to 200 mg per day.
High blood pressure is reduced with a dosage of 50-100 mg per day (must be taken in one dose), or the dose can be divided into four doses. The duration of therapy is 15 days. The drug can be combined with other antihypertensive agents.
For polycystic ovary syndrome, tablets are prescribed in a dosage of 100 mg twice a day.

The duration of therapy always differs in time. Usually the drug is prescribed for 5 days, then the daily dosage is slowly reduced and brought to 25 mg.

Many patients are interested in how to take the drug, before or after meals? It is recommended to take the tablets during or after meals; in addition, the medicine is always washed down with plenty of non-carbonated liquid.

It is worth noting that if you do not follow the instructions and recommendations and take the drug before meals, its effectiveness is reduced by 50%. Price for the drug Veroshpiron:

Tablets of 25 mg (20 pieces) from 80 to 90 rubles.
50 mg capsules (30 pieces) from 175 to 189 rubles.
Capsules 100 mg (30 pieces) from 250 to 310 rubles.

The price of a medicine may vary within small limits, depending on the manufacturer of the medicine.

A diuretic is prescribed with extreme caution if the patient has a history of diabetes mellitus, mild renal failure, cirrhosis of the liver, after surgery, as well as in patients of the elderly age group.

There are situations when taking the drug is strictly prohibited:

Not prescribed for children under 3 years of age.
In case of hypersensitivity to the active component - spironolactone, as well as to other components of the drug.
In severe renal failure.
Addison's disease, characterized by chronic deficiency of the adrenal cortex.
Patients with a high concentration of potassium in the body.
Patients with low sodium concentration in the blood.

The medicine is not recommended during pregnancy or lactation (spironolactone passes into breast milk). However, in some cases, in the 2-3 trimesters of pregnancy, the drug can be prescribed to eliminate edema in a woman.

In some cases, a diuretic may be prescribed to newborns who are diagnosed with heart failure. Such therapy does not last long and is always carried out in a hospital setting under the supervision of the attending physician. The drug Veroshpiron has “traditional” side effects:

Migraine.
Dizziness.
Drowsiness/insomnia.
Abdominal cramps.
Nausea (rarely vomiting).
Disorder of the functioning of the gastrointestinal tract.

Often, a diuretic also provokes specific side effects in the form of endocrine disorders:

Male patients may experience active breast growth.
The medicine reduces potency and causes erectile dysfunction.
Women may experience irregular menstrual cycles or no menstrual cycle at all.
For the weaker sex, critical days become too painful; bleeding in the uterus and pain in the sternum may occur.

But such side effects are temporary, and after stopping the use of the drug they disappear without additional therapy.

Like many other medications, this diuretic can provoke an allergic reaction, which is expressed in redness of the skin, itching and rash. If the drug is used for a long time, laboratory results may change.

Veroshpiron negatively combines with a number of other medications, so this drug should only be taken after a doctor’s prescription.

Spironolactone - an analogue of Veroshpiron

In situations where it is not possible to buy Veroshpiron, or the patient is intolerant to the excipients of the drug, it is better to replace it with an analogue - Spironolactone. Tablets can be prescribed in the following situations:

For swelling due to chronic heart failure, Spironolactone can be recommended as the only remedy or in combination with other medications.
Secondary and primary hyperaldosteronism.
Hypertension (in combination treatment).

Spironolactone for hypertension effectively reduces blood pressure, a pronounced effect occurs after 2-3 days of daily use. Method and dosage:

The tablets are taken orally with a sufficient amount of liquid.
The dosage of the medicine is recommended on an individual basis, depending on the degree of disturbance of the water and electrolyte balance, and the hormonal status of the patient.
If there is swelling due to hypertension, treatment begins with 100-200 mg (the dose is divided into three times). The therapy does not last long; after 2-3 weeks the drug is discontinued, since this time is usually enough to achieve the desired effect.
High blood pressure is reduced with a dose of 100-200 mg.
As a rule, the course of therapy is 15 days, then there is a break, after which you can begin repeated therapy to achieve the desired effect.

Instructions for use

Veroshpiron is not used in therapeutic practice as an independent remedy, but plays an important role in the treatment of certain diseases.

Indications for the use of Veroshpiron are conditions in which it is necessary to remove excess fluid from the body, but at the same time maintain water and electrolyte balance.

Veroshpiron is also used in the diagnosis of primary hyperaldosteronism.

Method of administration

An incorrectly selected dosage of the drug can lead to a deterioration in the patient’s condition due to a lack of therapeutic effect or an overdose.

The quantity and frequency of taking the medicine must completely coincide with the values recommended by the attending physician.

For EG, the initial dose of Veroshpiron is 50-100 mg per day. According to indications, the dosage is increased to 200 mg per day by adding 50 mg of the drug once every 15 days.

To achieve a lasting therapeutic effect, it is recommended to take the medicine for at least 2 weeks. Repeated dose adjustments may be required during treatment.

For hyperaldosteronism of unknown origin, drugs are prescribed in a daily dosage of 100 to 400 mg, depending on the severity of the symptoms of the disease.

In case of a complicated course of the disease against the background of developed hypokalemia, the maximum daily dosage is 400 mg.

The drug is taken three times a day in equal portions. If the dynamics are positive, the dosage is reduced to 25 mg per day.

For hypomagnesemia and hypokalemia, the development of which is provoked by taking diuretics, Veroshpiron is prescribed in a daily dose of 25 to 100 mg, and only if drugs with potassium are not effective.

For swelling, the drug is prescribed in a dosage of 100 or 200 mg. If edema appears due to CHF, the dosage remains the same, but the duration of therapy is 5 days, and the daily dose of the drug is divided into 2 or 3 doses.

After the patient's condition improves, the dosage can be reduced to 25 mg.

In preparation for surgical treatment of Conn's syndrome, Veroshpiron is prescribed in a dose of 100 to 400 mg, divided into 1-4 doses. In case of cancellation of the operation, an individual maintenance dose is selected at the lowest value.

For the treatment of edema in children, the drug is prescribed in a dosage calculated according to the formula 1-3 mg/kg of the child’s weight per day, divided into several doses (their maximum can be 4).

If necessary, after 5 days from the start of the course, the dosage can be increased, but not more than 3 times the original.

Arrhythmia is a violation of cardiac activity, deviations in the rhythm of heart contractions that are different in nature and origin. Find out more about symptoms and treatment:

Release form, composition

Veroshpiron is produced in the form of tablets and soft-shell capsules. The main active ingredient of both dosage forms is the compound spironolactone.

One tablet contains 25 mg, and a capsule contains 50 or 100 mg. In addition to the main component, the tablets contain additional (stabilizing) components.

They are also found in the contents of gelatin capsules.

Since the active substance of Veroshpiron enters the systemic bloodstream, the drug may interact with medications that are taken simultaneously with it.

When used together with direct and indirect anticoagulants, as well as with cardiac glycosides, a decrease in the toxicity of these drugs is observed.

The opposite effect is observed when taking Veroshpiron together with lithium preparations.

When taken together with glucocorticosteroids and diuretics based on furosemide, benzothiazine and ethacrynic acid, the diuretic effect increases, against which there is an increase in the loss of sodium ions. An increase in the effect of the drugs is also observed when taking antihypotensive drugs together with Veroshpiron.

When taken together with phenazoles, triptorelin and gonadorelin, the effect of the latter is enhanced due to their increased metabolism. At the same time, their half-life from the body is shortened.

Veroshpiron can significantly reduce the effectiveness of norepinephrine and mitotane. If it is necessary to use them together, dosage adjustment is recommended.

Indomethacin and salicylates significantly reduce the effect of Veroshpiron.

Side effects

During the course of treatment with Veroshpiron, adverse reactions may occur, many of which are not a reason to discontinue the drug:

dyspeptic disorders, pain in the abdominal area;
sleep disturbances, lethargy, dizziness;
changes in laboratory tests of blood and other body fluids;
endocrine disruptions (in women - deepening of the voice, metrorrhagia, amenorrhea or dysmenorrhea, in men - gynecomastia, as well as decreased libido and potency);
muscle spasms.

In rare cases, more severe side effects occur:

bleeding in the gastrointestinal tract;
confusion, hallucinations and lethargy;
allergic skin reactions;
acute renal failure;
If they occur, it may be necessary to discontinue the drug or review the dosage and reduce it.

Contraindications

hyperkalemia and hypernatremia;
severe form of renal failure;
intolerance to the components of the drug, including lactose;
Addison's disease.

Taking this drug is relatively dangerous for atrioventricular block, diabetes mellitus and diabetic nephropathy, cirrhosis of the liver. For these pathologies, the drug is prescribed only under round-the-clock supervision of medical staff.

During pregnancy

Pregnancy and lactation are considered serious contraindications to the use of Veroshpiron.

Storage conditions and periods

Suitable storage conditions are considered to be a temperature of 15 to 30 degrees and a low degree of humidity. Under such conditions, both dosage forms retain their properties for 5 years.

The cost of Veroshpiron depends on several factors, including the name of the pharmacy chains that distribute the drug.

In Russian pharmacies Veroshpiron tablets can be bought for an average of 78 rubles per pack. 50 mg capsules are slightly more expensive - from about 178 rubles per pack, while 100 mg capsules can be purchased for 263 rubles.

In Ukrainian pharmacy chains Veroshpiron in tablet form is sold for an average of 145 hryvnia per package, 50 mg capsules for 195 hryvnia, 100 mg capsules for 280 hryvnia.

Analogs

Veroshpiron has several structural analogues that contain the same list of components and have a similar effect on the body.

These include:

Vero-Spironolactone;
Spironol;
Spirix;

Despite the identical composition, replacing one drug with another requires the approval of the attending physician.