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Antiviral drugs. "Cycloferon": composition, indications, instructions for use, reviews

R N001049/02-dated 12/12/2007

Tradename:

Cycloferon ® (Сycloferon ®)

Dosage form:

enteric-coated tablets

Compound:

one tablet contains:
active substance- meglumine acridone acetate in terms of acridone acetic acid - 150 mg;
Excipients: povidone - 7.93 mg, calcium stearate - 3.07 mg, hypromellose - 2.73 mg, polysorbate 80 - 0.27 mg, methacrylic acid and ethyl acrylate copolymer - 23.21 mg, propylene glycol - 1.79 mg.

Description:

yellow biconvex tablets, enteric-coated.

Pharmacotherapeutic group:

immunostimulating agent.

ATX code:

L03AX

Pharmacological properties

Pharmacodynamics
Cycloferon is a low molecular weight interferon inducer, which determines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory, etc.).

Cycloferon is effective against herpes viruses, influenza and other pathogens of acute respiratory diseases. has a direct antiviral effect, suppressing the reproduction of the virus in the early stages (1-5th day) of the infectious process, reducing the infectivity of the viral offspring, leading to the formation of defective viral particles. Increases the body's nonspecific resistance to viral and bacterial infections.

Pharmacokinetics.
When taking a daily dose, the maximum concentration in blood plasma is reached after 2-3 hours, gradually decreases by the 8th hour, and after 24 hours Cycloferon is found in trace amounts. The half-life of the drug is 4-5 hours, so the use of the drug Cycloferon in recommended doses does not create conditions for cumulation in the body.

Indications for use:

In adults in complex therapy:

herpetic infection.

In children over four years of age in complex therapy:

influenza and acute respiratory diseases;

Herpetic infection.

In children over four years of age for the prevention of influenza and acute respiratory diseases.

Contraindications:

Pregnancy, lactation, children under 4 years of age (due to imperfect swallowing), individual intolerance to the components of the drug, decompensated liver cirrhosis.

Carefully
In case of diseases of the digestive system in the acute stage (erosion, gastric and / or duodenal ulcers, gastritis and duodenitis) and a history of allergic reactions, be sure to consult your doctor before taking the drug.

Use during pregnancy and during breastfeeding

Use during pregnancy and during breastfeeding is contraindicated.

Directions for use and doses

Inside, once a day, 30 minutes before meals, without chewing, drinking 1/2 glass of water, in age dosages:

children 4-6 years old: 150 mg (1 tablet) per dose;
children 7-11 years old: 300-450 mg (2-3 tablets) per dose;
adults and children over 12 years old: 450-600 (3-4 tablets) per dose.

It is advisable to repeat the course 2-3 weeks after the end of the first course.

In adults:
1. In the treatment of influenza and acute respiratory diseases, the drug is taken on the 1st, 2nd, 4th, 6th, 8th day (course of treatment - 20 tablets). Treatment should begin at the first symptoms of the disease.
For severe flu, take six tablets on the first day.
If necessary, symptomatic therapy is additionally carried out (antipyretic, analgesic, expectorant drugs).
2. In case of herpetic infection, the drug is taken on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd days (treatment course 40 tablets). Treatment is most effective when the first symptoms of the disease appear.

In children from four years of age:
1. For influenza and acute respiratory diseases, the drug is taken in age-specific doses on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23. The course of treatment ranges from 5 to 10 doses, depending on the severity of the condition and the severity of clinical symptoms.
2. For herpes infection, the drug is taken on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th day of treatment. The course of treatment may vary depending on the severity of the condition and the severity of clinical symptoms.
3. For emergency nonspecific prevention of influenza and acute respiratory diseases (in direct contact with patients with influenza or acute respiratory infections of another etiology, during an influenza epidemic): on the 1st, 2nd, 4th, 6th, 8th day. Next, take a break of 72 hours (three days) and continue the course on the 11th, 14th, 17th, 20th, 23rd day. The general course is from 5 to 10 doses.

Side effect

Allergic reactions.

Overdose

There is no information about an overdose of the drug.

Interaction with other drugs

Cycloferon is compatible with all drugs used in the treatment of these diseases (interferons, chemotherapy, symptomatic drugs, etc.). Enhances the effect of interferons and nucleoside analogues. Reduces the side effects of chemotherapy, interferon therapy.

special instructions

Cycloferon does not affect the ability to drive vehicles.
For diseases of the thyroid gland, consultation with an endocrinologist is necessary.
If the next dose of the drug is missed, you should continue the course according to the started regimen as soon as possible, without taking into account the time interval and doubling the dosage.
If there is no therapeutic effect, you should consult a doctor.

Release form:

Enteric-coated tablets, 150 mg. 10 or 20 tablets in blister packs. 1 blister pack of 20 tablets, 1 or 5 blister packs of 10 tablets with instructions for use in a cardboard pack.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children.

Best before date

2 years.
Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies:

Over the counter.

Company manufacturer:

LLC Scientific and Technological Pharmaceutical Company POLYSAN (LLC NTFF POLYSAN).

A drug from the group of immunostimulants. Prescribed for infectious diseases of both viral and bacterial origin. The medicine has a wide practice of use and has long gained trust among doctors and patients. Cycloferon is able to suppress the activity of autoimmune reactions, as well as reduce the manifestations of allergies and inflammatory processes. Suitable for treating adults and children.

Dosage form

Cycloferon is a domestically produced drug. It is presented on the market in several pharmaceutical forms, each of which contains a certain amount of active ingredient.

The tablets are intended for oral administration and are coated with a yellow coating. The drug is produced in a package containing blister No. 10 or 50 tablets.
Liniment (ointment, gel) has a characteristic odor. In pharmacies you can buy it in tubes of 5 or 30 ml.
The drug solution is sold in ampoules of 2 ml. The package contains 5 ampoules.

Description and composition

Cycloferon is an antiviral drug that increases the resistance of the human body. The medicine belongs to high-molecular activators and has high pharmacological activity. The medicine is used in the treatment of diseases of viral origin, and can also be used in the complex treatment of certain diseases of bacterial origin, as an immune stimulant. Cycloferon shows its activity in the treatment of many diseases. It has the ability to suppress autoimmune reactions and has a wide spectrum of action. This drug has been present on the pharmacological market for more than 20 years. During this period, it has proven its effectiveness in various immunodeficiency conditions.

The active component of the drug is the compound acridoneacetic acid; it also contains auxiliary components, which vary depending on the form of release of the drug.

Tablets in their composition contain 150 mg of the active substance, also povidone, Ca salts, polymers, propylene glycols, cellulose.
Linimenta Cycloferon contains 50 mg of acridoneacetic acid. As auxiliary components - meglumines, propylene glycols, benzalkonium.
One ml of solution - 125 mg of the active ingredient, as well as meglumines, sterile water.

Pharmacological group

Cycloferon is a stimulator of the synthesis of interferon proteins, which takes part in the body's immune reactions, increases the body's resistance to various pathogenic bacteria and viruses. The drug has a pronounced antitumor, antiviral and anti-inflammatory effect. The mechanism of action of the drug is as follows:

enhances production;
takes part in the activation of the process of phagocytosis;
inhibits and destroys the growth and reproduction of pathogenic viruses and bacteria;
has an antitumor effect;
relieves inflammation;
prevents the spread of tumor metastases in the body.

The active ingredient of the drug has the ability to penetrate the protective barriers of the body, including the circulatory system, brain tissue. The maximum concentration of the drug in the blood is noted within 3 hours after taking the drug and persists for 8 hours. The medicine Cycloferon has two main properties - it increases immunity, has a pronounced antiviral effect. Therapy using Cycloferon is able to have an antiproliferative effect, that is, to suppress excessive cell growth. After penetration into the body, the active substance of the drug - meglumine acridone acetate promotes the synthesis of interferons α and β.

Megluminacridone acetate, which is the basis of Cycloferon, provides a wide spectrum of action. The drug effectively copes with various viruses and bacteria, improves immunity, prevents and stops the growth of tumors. Taking the drug allows you to suppress autoimmune (allergic) reactions, thereby reducing the manifestation of allergy symptoms and inflammatory reactions.

With external use of the drug, it increases local immunity, protects the skin, stops the penetration of viral DNA into the cell.

Indications for use

Due to the wide spectrum of action of the drug, it is widely used in various fields of medicine. The drug can be used for therapeutic and prophylactic purposes in adults and children over 4 years old.

For adults

Cycloferon in the form of tablets and solution for injections can be prescribed in the complex therapy of the following diseases:

flu or acute respiratory infections;
herpes;
neuroinfections;
encephalitis;
serous;
secondary immunodeficiency;
HIV infection in stages 2A-3B;
Lyme disease;
candidiasis of various etiologies;
papilloma virus (warts);
cytomegalovirus infections;
rheumatoid arthritis;
systemic lupus erythematosus.

These are not all diseases whose treatment may include taking Cycloferon. Only a doctor can prescribe the drug based on the diagnosis and characteristics of the body.

For children

In pediatrics, the drug can be prescribed to children from 4 years of age. The following diseases may be indications for taking medication in children:

acute respiratory infections;
flu;
herpetic infections of skin and tissues;
hepatitis C and B;
intestinal infections;
systemic and rheumatic diseases of connective tissue.

For children, the drug Cycloferon can only be prescribed by a doctor based on the final diagnosis.

The instructions for the drug contain information that Cycloferon is contraindicated for pregnant and nursing mothers.

Contraindications

The drug Cycloferon has some contraindications for use:

increased sensitivity to the composition;
cirrhosis of the liver;
illness;
children under 4 years old;
pregnancy;

You can take the drug only after excluding a history of diseases or conditions that are on the list of contraindications.

Applications and dosages

The instructions for the drug contain standard doses of the drug, but only a doctor can prescribe the medicine based on the diagnosis and stage of the disease.

For adults

For adults, Cycloferon tablets are prescribed for a course of 10–14 days. You can take 2 - 3 tablets 1 - 2 times a day. It is recommended to take the drug 30 minutes before meals. The treatment course is determined by the doctor. The drug is especially effective in the initial stages of the disease.

Cycloferon solution is intended for intravenous jet or intramuscular administration. The dose is individual, it can be 0.25 to 0.5 g for 1 - 2 weeks.

For genital infections of the skin and mucous membranes, intraurethral instillations are performed using external liniment, 5 ml, for a course of 7–14 days.

For children

In pediatrics, the drug is used for children from 4 years of age. Children from 4 to 6 years old are prescribed only the injection form of the drug. From 7 to 12 years old, 3 tablets per day can be used. The therapeutic course is 1 - 2 weeks. For children, medicine can only be prescribed by a doctor and only after a final diagnosis has been made.

For pregnant women and during lactation

The drug is contraindicated for pregnant women, so there are no doses.

Side effects

In rare cases, after taking the drug, adverse reactions of the body may occur. In the practice of doctors, the following conditions are often encountered:

allergic reactions - skin itching, rash, peeling of the skin;
increased body temperature;
skin hyperthermia;
nausea, urge to.

If symptoms of side effects appear, the doctor may stop taking the drug and prescribe analogues. Most often, if you are intolerant to Cycloferon, the doctor may prescribe other drugs with a similar mechanism of action as analogues.

Interaction with other drugs

Cycloferon is well tolerated. The drug can be used in combination with other drugs. The only exception to co-administration is taking Cycloferon with other antiviral and immunostimulating agents. The drug interacts well with antibiotics, cytostatics and other drugs. Taking this drug often increases the effectiveness of other medications.

special instructions

When taking Cycloferon in the first days of illness, symptoms such as body aches, fever, lethargy, and headaches may appear. Such symptoms are a normal reaction of the body and will go away on their own within a few days.

It is important to understand that Cycloferon is an antiviral drug, so they cannot be replaced with antibiotics, but can be taken together with this group of drugs.

The drug Cycloferon does not affect the psychomotor reactions of the body and does not inhibit the functioning of the central nervous system. Only a doctor can adjust the dose of the drug. If adverse reactions occur in the body, the doctor may replace the drug with similar drugs.

Overdose

Cases of drug overdose are very rare, but in some cases, if the dose of the drug is exceeded, symptoms of adverse reactions of the body may appear.

Storage conditions

The drug is a prescription drug. The medicine can be stored at a temperature not exceeding 25⁰C out of the reach of children. The shelf life of the drug is 3 years from the date of release of the drug.

Analogs

You can replace Cycloferon with the following medications:

- a domestic antiviral drug produced in tablets. It is a substitute for Cycloferon in the clinical and pharmacological group. It can be given to patients over 3 years of age for the treatment and prevention of acute respiratory viral infections, including influenza. Adults can take the tablets for herpes infections.
contains trilon as an active component. Tablets of 60 mg can be prescribed to children over 7 years of age for the treatment of ARVI. The drug in a dosage of 125 mg is prescribed to adult patients for the treatment and prevention of ARVI. It is also prescribed to adults for herpes, cytomegalovirus infection, hepatitis of viral etiology, chlamydia, tuberculosis.

Drug price

The cost of Cycloferon is on average 416 rubles. Prices range from 157 to 858 rubles.

Cycloferon is an effective antiviral, as well as an immunomodulatory drug that helps cope with various diseases of infectious and inflammatory origin.

This drug has a pronounced antiviral effect against many strains of viral pathogens (influenza, herpes, viral hepatitis, tick-borne encephalitis, etc.).

Cycloferon, when used regularly, also exhibits good anti-inflammatory and analgesic (pain-relieving) effects quite quickly and effectively eliminating the inflammatory process.

An antiviral drug can be prescribed both for the prevention of various infectious diseases and for the complex treatment of influenza, acute respiratory viral infections and other infectious and inflammatory processes.

Regular use of Cycloferon helps to significantly strengthen the body's immunity, while preventing the risk of possible development of viral diseases.

Main indications for the use of Cycloferon:

herpes infection (herpes);
flu or cold;
viral hepatitis A, B, C, D;
neuroinfection;
rheumatic inflammatory diseases (rheumatoid arthritis, radiculitis, osteoarthritis);
cytomegalovirus infection;
HIV infection.

Attention: Before starting to use Cycloferon, it is recommended to consult with a qualified general practitioner!

The drug is produced in the form of soluble tablets for internal use, as well as a solution for intramuscular or intravenous injection.

How to take Cycloferon?

The daily dose of Cycloferon for adults is 1 t. 2-3 r. per day, preferably 20-30 minutes. Before meals, drink plenty of water.

For children, the required daily dose is determined by the attending physician absolutely individually for each child, depending on the age and severity of the specific disease.

4-7 years: 1 t. (150 mg.) 1 r. for a day;
8-12 years: 1 t. 2 rubles/day;
13-16 years old: 1 t. 2-3 rubles/day.

The average duration of treatment with Cycloferon is 7-10 days, while a second course of taking this drug can be carried out, but not earlier than 2-3 weeks.

In case of sufficiently severe infectious and inflammatory diseases, the use of this drug in the form of injections may be prescribed.

Contraindications to the use of Cycloferon

pregnancy and lactation (breastfeeding);
hypersensitivity (increased sensitivity of the body to the main active ingredient of the drug);
severe liver disease (cirrhosis);
child's age up to 4 years;
stomach ulcer (this drug may be used with extreme caution).

Side effects of Cycloferon

As a rule, this antiviral drug is tolerated quite well by patients, but extremely rarely, local allergic reactions on the skin may develop (urticaria, increased skin itching, etc.).

If any allergic reactions occur, it is recommended to consult your doctor!

In this article, we found out what Cycloferon helps with, as well as how to take it correctly.

Composition of the medicinal product Cycloferon

Cycloferon tablets
Active ingredients: acridoneacetic acid (150 mg per tablet), N-methylglucamine (146 mg per tablet).
Inactive substances: calcium stearate, methylcellulose.

Solution for injections Cycloferon
Active ingredients: acridoneacetic acid (125 mg in 1 ml, 250 mg in 1 ampoule).
Inactive substances: water for injection, stabilizing and salt-forming additive (N-methylglucamine 192.9 mg in 2 ml).

Cycloferon liniment
Active components: acridoneacetic acid in the form of N-methylglucamine salt (50 mg per 1 g of liniment).
Inactive substances: 1,2-propylene glycol up to 100% (base), catapol 0.1% (antiseptic).

Dosage form

Cycloferon tablets are covered with an enteric coating of brown-golden or brown color. Tablets are available in polymer or dark glass jars (50 pieces each) and in blisters of 10 pieces. There are 1 or 5 blisters in a cardboard box.

Cycloferon – solution for injection – in ampoules of 2 ml (12.5%). The ampoule contains a yellow, transparent liquid. 1 ml of solution for injection contains 125 mg of the drug (1 ampoule – 250 mg). There are 5 ampoules in contour packaging in a cardboard box.

Cycloferon liniment 5% is a yellow liquid ointment, 5 ml in a tube.

Pharmacotherapeutic group

Medicines that stimulate immune processes

Pharmacological properties

Cycloferon is an immunomodulatory and antiviral agent. The drug is a high-molecular inducer of the formation of endogenous interferon. The effectiveness of the drug is due to a wide range of biological activity: anti-inflammatory, antiproliferative, antiviral, immunomodulatory, antitumor effects. Cycloferon, when introduced into the body, potentiates the formation and content of high titers of beta and alpha interferons in tissues and organs.

Particularly high levels of interferons are determined in tissues and organs containing a large number of lymphoid elements: liver, spleen, lungs, intestinal mucosa. The drug also activates bone marrow stem cells, causing intensive formation of granulocytes. Normalizes the ratio of T-helpers and T-suppressors, promotes the activation of killer cells and T-lymphocytes. In case of immunodeficiencies of various origins, this causes a correction of the body's immune status. Able to penetrate the blood-brain barrier.

Cycloferon causes clinical improvement in viral infectious diseases (herpes, influenza, tick-borne encephalitis, hepatitis, cytomegalovirus infection, HIV infection, papillomatous and enterovirus infections). Thanks to the activation of the immune system, it has antichlamydial and antimicrobial effects. Prevents the formation of tumor processes in the body due to antimetastatic and anticarcinogenic effects. Suppresses the body's autoimmune reactions, which is manifested by a decrease in the severity of pain and inflammation in systemic connective tissue diseases and rheumatic diseases.
When applied topically, Cycloferon improves the balance of the immune system and also has antiproliferative and anti-inflammatory effects.

After internal administration of Cycloferon in the maximum permissible dosage, the active substance is detected in maximum plasma concentration after 2-3 hours. In the future, the concentration of the drug decreases by 8 hours. A day after taking Cycloferon can be detected in the body in trace concentrations. The half-life is 4-5 hours. When Cycloferon is prescribed in recommended dosages, no accumulation of the active substance is observed.

Indications for use Cycloferon

Cycloferon - tablets

herpetic infection,
influenza and acute respiratory infections (acute respiratory diseases),
acute intestinal infections,
neuroinfections (including tick-borne borelliosis - Lyme disease, serous meningitis),
secondary immunodeficiency caused by chronic fungal and bacterial infections.
viral chronic hepatitis C and B,

In pediatrics - as part of complex therapy for:
herpetic infection,
viral chronic and acute hepatitis C and B,
acute intestinal infections,
for the treatment and prevention of acute respiratory diseases and influenza.

For adults – as part of complex therapy for:
HIV infection in clinical stage 2A-3B,
viral hepatitis C, A, D and B,
systemic connective tissue diseases and rheumatic diseases (systemic lupus erythematosus, rheumatoid arthritis),
neuroinfections (including tick-borne borelliosis - Lyme disease, serous meningitis, encephalitis),
cytomegalovirus or herpetic infection,
secondary immunodeficiency caused by chronic or acute fungal and bacterial infections,
chlamydial infections,
degenerative-dystrophic diseases of the joints (including deforming osteoarthritis).

In pediatrics (children over 4 years old) - as part of complex therapy for:
viral hepatitis C, A, D, GP and B,
herpetic infection,
HIV infection in clinical stage 2A-3B.

As a component of complex treatment in adults for:
herpetic infection,
therapy of nonspecific vaginosis and bacterial vagititis,
treatment of balanoposthitis, urethritis of specific (chlamydial, gonorrheal, trichomonas), candidiasis and nonspecific etiology.

Contraindications

For internal administration and parenteral administration – liver cirrhosis (decompensated),
allergic reactions to cycloferon and other components of the product.

Cautions for use

Pregnancy:
Cycloferon is contraindicated for pregnant women and nursing mothers. Cycloferon liniment may not be contraindicated during lactation.
The use of the drug orally or by injection for thyroid diseases should be carried out under the close supervision of an endocrinologist.

Interactions with drugs

The drug is fully compatible with other drugs that are prescribed for the treatment of these diseases (including chemotherapy drugs and interferons).

Directions for use and dosage: Cycloferon

Cycloferon - tablets
Prescribed once a day half an hour before meals. Take the tablet with water, do not chew it.

For herpetic infections for adults, Cycloferon is prescribed in 2-4 tablets according to the following regimen: days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 (basic regimen) - for a total course of therapy – 20-40 tablets (3-6 g). Treatment begins at the time of exacerbation of the disease.

For acute respiratory infections and flu - 2-4 tablets once a day. A total of 10-20 tablets (1.5-3 g) per course of therapy. Prescribed at the first symptoms of the disease. In case of severe clinical picture, you can use 6 tablets for the first dose. Treatment with Cycloferon is combined with painkillers, antipyretics and expectorants (if necessary and according to indications).

For viral chronic hepatitis C and B - 4 tablets per dose according to the following scheme: days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23. Next, they switch to maintenance use of the drug, 4 tablets once every 3-5 days for 3.5 months (if the cytolytic and replicative activity of the infectious process persists). A total of 100-150 tablets per course of treatment. The course of therapy must be repeated if the patient has viral hepatitis C or a mixed form of infection. Repeated courses of Cycloferon are prescribed 2 times: each - 1 month after the end of the previous one. Prescribed in combination with antiviral agents and interferon.

For intestinal infections (as part of complex treatment), 2 tablets are prescribed per dose according to the following scheme: days 1, 2, 4, 6, 8. Next - take 2 tablets on the 11th, 14, 17, 20 and 23rd days. A total of 20 tablets (3 g) per course of treatment.

For neuroinfections, 4 tablets are prescribed per regimen: days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23. Then they switch to a maintenance dosage - taking 4 tablets once every 5 days. The total duration of treatment is 2.5 months (100 tablets - 15 g).

For HIV infection in clinical stages 2A-3B, 4 tablets are prescribed per regimen: days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 of treatment. Then they switch to a maintenance dosage: take 4 tablets once every 3-5 days. The duration of treatment is 2.5 months. A total of 100-150 tablets per course. After completing the previous course, 2-3 weeks later the treatment is repeated according to the same scheme.

For immunodeficiencies, 2 tablets are prescribed according to the following regimen: days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 of treatment. A total of 20 tablets (3 g) per course of therapy.
In pediatrics, Cycloferon is prescribed in the following doses: for children 4-6 years old - 1 tablet (150 mg), at the age of 67-11 years - 2 tablets (300 mg), from 12 years old - 3 tablets (450 mg). mg) 1 time per day. If a repeat course of therapy is necessary, Cycloferon is prescribed 2-3 weeks after the end of the previous course.

Viral acute hepatitis C and B: apply the recommended dosage for children 2 times with an interval of 24 hours. Then prescribed 3 times with an interval of 48 hours. Subsequently, 5 doses of Cycloferon are used every 72 hours. Depending on age, the total course of therapy is 10-30 tablets.

Viral chronic hepatitis C and (or) B: Cycloferon is prescribed in the dosages recommended for children with an interval of 48 hours. A total of 50-150 tablets per course of treatment (depending on age).

For HIV infection in clinical stage 2A-3B, Cycloferon is prescribed to children in the recommended dosage according to the following scheme: days 1, 2, 4, 6, 8, 11, 14, 17, 20 of treatment. Then they switch to a maintenance dose once every 3-5 days for 5 months.

For herpes infection, it is prescribed according to the following scheme: days 1, 2, 4, 6, 8, 11, 14 of treatment. The duration of taking the drug depends on the severity of clinical manifestations and the severity of the disease.

For acute intestinal infections, it is prescribed according to the following scheme: days 1, 2, 4, 6, 8, 11 of treatment once a day in doses recommended for children. A total of 6-18 tablets per course of treatment.

During an unfavorable epidemiological situation, for the prevention of influenza and acute respiratory diseases, Cycloferon is prescribed in doses recommended for children according to the following scheme: days 1, 2, 4, 6, 8, then another 5 times with an interval of 72 hours. For a course of treatment - 10-30 tablets.
For influenza and acute respiratory diseases, Cycloferon is prescribed in doses recommended for children with an interval of 24 hours. For a course of treatment – 5-9 doses of the drug (1 time per day).

Cycloferon for parenteral use
A basic drug administration regimen is used (days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 26, 29 of treatment), which will depend on the type of disease. Use intravenously or intramuscularly 1 time per day.

For viral hepatitis B, A, D, C, a single dose of Cycloferon is 250-500 mg. A total of 10 injections per course of treatment according to the basic scheme. The total total dose is 2.5-5 g. The course is repeated after 10-14 days.

For cytomegalovirus and herpetic infections, Cycloferon is prescribed according to the basic regimen. A total of 10 injections of 250 mg per course of treatment. The total total dose is 2.5 g. The most effective use of the drug is at the beginning of an exacerbation of the disease.

For neuroinfections, Cycloferon is prescribed according to the basic regimen. A total of 12 injections of 250-500 mg per course of therapy. Treatment with the drug should be combined with etiotropic therapy. The total total dose is 3-6 g. If necessary, therapy can be repeated.

For HIV infection in clinical stages 2A-3B, Cycloferon is prescribed in a single dose of 500 mg intramuscularly. A total of 10 injections per course of treatment according to the basic regimen. The total total dose is 5 g. After completing the basic course, maintenance treatment is prescribed once every 5 days for 2.5 months. 1 month after the end of the last course, a second course of therapy is prescribed.

For chlamydial infections, Cycloferon is prescribed at a dose of 250 mg. A total of 10 injections per course of treatment. The total total dose is 2.5 g. 10-14 days after the end of the last course, a second course of therapy is prescribed.
A combination of Cycloferon with antibacterial drugs is recommended.

For immunodeficiency conditions, 10 injections are prescribed per course of treatment. Apply intramuscular administration of the drug in a single dose of 250 mg according to the basic scheme. The total total dose is 2.5 g. 6-12 months after the end of the last course, a second course of therapy is prescribed.

In case of systemic diseases of the connective tissue and rheumatic diseases, the basic scheme for the administration of Cycloferon is prescribed for 5 injections (4 courses). Dose - 250 mg with an interval of 10-14 days. The need for re-appointment of Cycloferon is determined by the doctor individually.

For degenerative-dystrophic diseases of the musculoskeletal system, 250 mg is prescribed according to the basic scheme - only 2 courses of 5 injections with an interval of 10-14 days. The need for re-appointment of Cycloferon is determined by the doctor individually.
In pediatrics: the daily dose of Cycloferon is calculated based on 6-10 mg / kg of the patient's body weight. It is used intramuscularly or intravenously once a day.

For viral acute hepatitis B, A, C, GP, D and mixed forms, Cycloferon is prescribed according to the following scheme: 1st, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28th day of treatment. In case of prolonged infection, the course must be repeated after 10-14 days.

For viral chronic hepatitis C, B, GP, D, Cycloferon is prescribed according to the following scheme: days 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 of treatment. Then - maintenance therapy once every 3 days for 3 months (if the cytolytic and replicative activity of the infectious process persists).

For HIV infection, Cycloferon is prescribed according to the following scheme: days 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 of treatment. Then maintenance therapy is used once every 5 days for 3 months (if the replicative activity of the infectious process persists). For mixed forms of infections (HIV infections, hepatitis), chronic hepatitis C, it is possible to extend maintenance treatment for up to 6 months.

For herpes infection, Cytcloferon is prescribed according to the following scheme: days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 of treatment. Therapy can be continued for up to 4 weeks of maintenance dosage - a single dose every 5 days.

Cycloferon for local use
For herpetic infection: Cycloferon liniment is applied to the affected area in a thin layer once a day for 5 days. In the case of genital herpes, daily intraurethral and/or intravaginal instillations of 1 bottle of liniment (5 ml) are performed once a day for 10-15 days. Liniment can be combined with other local and systemic antiherpetic agents.

For candidiasis and nonspecific urethritis, instillations are carried out into the urethra in the amount of 1-2 bottles (5-10 ml). The dose depends on the level of damage to the urethra. In the case of a pathological process in the area of the anterior section of the male urethra, the cannula of the syringe with the collected Cycloferon liniment is immersed in the external opening of the urethra, after which the opening is compressed for 1.5-3 minutes. After some time, the instillation solution is released by gravity. After half an hour, the patient should urinate, since longer exposure to Cycloferon can cause swelling of the urethral mucosa. In case of damage to the posterior urethra and (or) seminal glands, intraurethral instillations of the drug are used through the urethral catheter in the amount of 1-2 bottles (5-10 ml) of Cycloferon liniment for 10-14 days 1 time per day every other day. A total of 5-7 instillations per course of treatment.
For the treatment of specific urethritis, an addition in the form of specific antibacterial agents used according to standard schemes is necessary.

With candidal colpitis, bacterial vaginosis, nonspecific colpitis and (or) endocervicitis, it is possible to use Cycloferon as monotherapy or as part of complex treatment. Apply Cycloferon-liniment instillations into the vagina in the amount of 1-2 vials (5-10 ml) for 10-15 days every day. To avoid free leakage of the liniment, the entrance to the vagina must be plugged with a small sterile cotton swab for 2-3 hours. When intravaginal and intraurethral infections are combined, it is recommended to use combined instillations into the vagina and urethra in the amount of 1 vial (5 ml) for 10-15 days every day. It is allowed to use liniment in the form of tampons soaked in the drug.

Cycloferon liniment can be combined with other official vaginal dosage forms in case of chronic diseases (vaginal suppositories, tablets).

Side effects

Allergic manifestations to cycloferon and other components of the drug.

Overdose

Information is absent.

Storage conditions

It is recommended to store Cycloferon in a dry place, protected from light, at a temperature of 18-20°C. Tablets and liniment are stored for no more than 2 years; injection solution – 3 years. Short-term freezing of the injection solution is allowed (during transportation) - this does not change the medicinal and physicochemical properties of the drug. Frozen injection solution must be thawed only at room temperature. If a precipitate forms or the color of the injection solution changes, the drug should not be used.

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Stock

dyucha speech: 1 tablet of acridonic acid 150 mg (0.15 g);

additional speeches: meglumin, povidone, calcium stearate, hypromelose, polysorbate 80; intestinal membrane: methacrylate copolymer dispersion, propylene glycol.

Medicine form

Tablets, coated, intestinal.

Pharmacotherapeutic group

Immunostimulants. ATC code L0ZAKH.

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Treatment in adults at the warehouse of complex therapy:

herpetic infections;
acute intestinal infections;
chronic viral hepatitis B and C;
flu and acute respiratory illnesses;
neuroinfection (serous meningitis, tick-borne borelosis (Lyme disease);
Vil infections (stages 2A-2B);
secondary immunodeficiencies that are associated with chronic bacterial and fungal infections.

Likuvanna in children in 4 years of age:

acute and chronic hepatitis B and C;
herpetic infections;
prevention and treatment of influenza and acute respiratory illnesses;
acute intestinal infections;
in complex therapy of HIV infection (stage 2A-2B).

Contraindicated

Decompensated liver cirrhosis. Increased sensitivity to the components of the drug.

Method of congestion and dosage

CYCLOFERON ® should be taken internally 1 time per day, days before meals. Roll the tablet whole without breaking it.

Let's grow up:

1. In case of herpetic infection, take the drug 2–4 tablets at a time on 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23rd day of treatment (course – 3–6 g, 20–40 tablets). Likuvannya begins on the cob of food.

2. For treatment of flu and acute respiratory illnesses, take 2–4 tablets per dose on the 1st, 2nd, 4th, 6th, 8th dose (course – 1.5–3 g, 10–20 tablets). Treatment should be started at the first symptoms of infection. In case of severe illness, take 6 tablets for the first dose. If necessary, additionally carry out symptomatic therapy (fever, pain relief, decongestants).

3. For chronic viral hepatitis B and C, the drug should be taken 4 tablets at a time on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd dose of treatment and beyond - according to the prescribed regimen: 1 time for 3–5 days over a period of 2.5 months while sparing the replicative and cytolytic activity of the pathological process (course – 100–150 tablets). In case of chronic hepatitis C and mixed forms of hepatitis, the treatment course is repeated 1-2 times a month after the previous one is completed. It is recommended to combine it with interferons and antiviral drugs.

4. For complex therapy of intestinal infections, a basic course of 2 tablets at a time on days 1, 2, 4, 6, 8 and beyond - 2 tablets on days 11, 14, 17, 20 and 23 (course – 3 g, 20 tablets).

5. In case of neuroinfections, take a basic course of 4 tablets at a time for the 1st, 2, 4, 6, 8, 11, 14, 17, 20 and 23rd dose and beyond - with a follow-up regimen of 4 tablets at a time 1 time for 5 days for 2.5 months (course 15 g, or 100 tablets).

6. In case of HIV infection (stage 2A–2B), the drug should stagnate on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th, 23rd day, 4 tablets per dose, then - 4 tablets per dose. once every 3–5 days for 2.5 months (course – 100–150 tablets). A repeat course should be carried out 2-3 years after completion of the previous one.

7. In immunodeficient countries, take a basic course of 2 tablets at a time on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 (course of 3 g or 20 tablets).

Children are 4 years old CYCLOFERON ® is assigned to the following basic scheme:

4–6 rokiv – 0.15 g each (one tablet), 7–11 rokiv – 0.3 g each (2 tablets), vicom 12 rokiv – 0.45 g (3 tablets) per dose, 1 time per dose . The repeat course must be completed 2–3 years after completion of the first course.

1. For acute viral hepatitis, B and C are prescribed at the indicated higher doses for 2 doses with an interval of 24 years, then - for 3 doses with an interval of 48 years, then - for 5 doses with an interval of 72 years (course, permanently, - 1 0 –30 tablets).

2. For chronic forms of hepatitis B and/or C, the drug is prescribed at the indicated doses at intervals of 48 years (course, daily, 50–150 tablets).

3. For HIV infection (stages 2A-2B), the drug is followed by the basic regimen on days 1, 2, 4, 6, 8, 11, 14, 17, 20 of therapy, then once every 3-5 days lasting 5 months.

4. In case of herpetic infection, freeze on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th day of treatment. The course of treatment can be varied depending on the severity and severity of clinical symptoms.

5. For acute intestinal infections, the drug is prescribed on the 1st, 2nd, 4th, 6th, 8th, 11th day of treatment once per dose (course – 6–18 tablets).

6. As an emergency non-specific prevention of acute respiratory illness and influenza during the period of advanced illness, the drug is prescribed at the indicated doses on the 1st, 2nd, 4th, 6th, 8th day, and further 5 doses at an interval of 72 years (course – 10 –30 tablets).

7. For acute respiratory viral infections, the drug is administered at intervals

24 years old 1 dose per dose (the course of treatment is 5–9 doses).

Adverse reactions

When the drug is ingested, allergic reactions are possible, including skin tingling, itching, dill, angioedema, increased body temperature.

Overdose

Not recorded.

It is possible to intensify the manifestation of side reactions when overdosing the drug.

Suspension during pregnancy or breastfeeding

Do not restrict women during the period of pregnancy and breastfeeding.

Children

Features of stastosuvannya

In case of illness of the thyroid gland, it should be frozen under the supervision of an endocrinologist.

This is due to the fluidity of the reaction during treatment with vehicles or robots with other mechanisms.

Doesn't flow in.

Interactions with other medicinal drugs and other types of interactions

CYCLOFERON ® has a wide range of medicinal properties that can be used when treating illnesses (interferons, chemotherapy drugs, etc.).

Pharmacological authorities

Pharmacodynamics. CYCLOFERON ® is a low-molecular-weight interferon inducer that provides a wide range of biological activity (antiviral, immunomodulatory, anti-inflammatory, antiproliferative, anti-tumor). The drug induces high titers of alpha and beta interferon in organs and tissues that contain lymphoid elements (mucous membrane of the small intestine, spleen, liver, legions), and also hematoencephalic bar"er.

CYCLOFERON ® is effective in the treatment of illnesses caused by tick-borne encephalitis viruses, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, and various enteric viruses. Enhances the antibacterial effect of antibiotics, which are used for the treatment of acute intestinal infections. The drug has an anti-carcinogenic and antimetastatic effect, preventing the formation of tumors through the activation of the immune system in the body.

The immunomodulatory effect of CYCLOFERON ® lies in the activation of phagocytosis, natural cell-killers, cytotoxic T-lymphocytes and correction of the immune status of the body in immunodeficient conditions of various types.

Pharmacokinetics. When the maximum permissible dose is taken, the maximum concentration in blood plasma is reached after 2–3 years, gradually decreasing over the next 8 years. After 24 years, CYCLOFERON ® appears in trace amounts. The drug administration period is 4–5 years. Thus, the use of CYCLOFERON ® in recommended doses does not prevent its accumulation in the body.

Main physical and chemical authorities

tablets, biconvex, yellow color, closed with an intestinal coating.

Term of attribution

Do not pack the drug after completing the terms of reference indicated on the package.

Wash away the savings

Store in a dry, bright place at a temperature not exceeding 25 ºС. Keep out of the reach of children.

Package

10 tablets per blister; 1 or 5 blisters per cardboard box.