Methylene blue overdose. Methylene blue solution for many diseases
To study microorganisms, microscopy is performed on both living and dead microbes in unstained and stained form.
A microscopic specimen is prepared on a glass slide. Slides must be crystal clear and completely free of grease. On the surface of degreased glass the water spreads easily and does not form spherical droplets.
Daughter and birth scars on the surface of yeast cells.
Before use, new glasses are boiled in a 1% soda solution for 10 minutes, washed with water, weak hydrochloric acid and rinsed well in distilled water.
After the study, the glasses must be treated with a solution of sulfuric acid for 2 hours, rinsed well in water and boiled for 10 minutes in a 4% soda solution. The glass, then rinsed with distilled water, is wiped with a clean linen cloth.
It is best to store slides in a jar with a ground stopper, immersed in a mixture of alcohol and ether, taken in equal volumes. The glass slides are removed from the jar with tweezers.
Cover glasses are thin pieces of glass (0.15-0.17 mm thick) usually measuring 18x18 mm, 20x20 mm, 18x24 mm. They cover the preparation on a glass slide for examination.
How to prepare a methylene blue solution
Physiological solution of sodium chloride with methylene blue: methylene blue 0.1 g; physiological sodium chloride solution - 100.0 ml. Weigh out the above amount of methylene blue and place it in a clean bottle. Add physiological sodium chloride solution and mix thoroughly until the paint crystals are completely dissolved. To work, filter a small amount of paint solution into a dropper. 
Technique for preparing paint from dry powder. A certain amount of malachite green or methylene blue powder is ground with a pestle in a clean, dry mortar. Weigh out 3 g of paint powder, pour it into a bottle and add distilled water to make 100 ml of solution. To prepare the working solution, pour 1 ml of one of the 3% aqueous paint solutions obtained above into a 250 ml bottle. Add 100 ml of glycerin and 100 ml of distilled water; Before use, the solution is thoroughly mixed.
Where can I get methylene blue?
Mat, scalpel, methylene blue.
If you have a home microscope, the question arises, where to get the preparations?
It's very simple: this drug is sold in stores and is used in aquarium farming. Look at the photo. Also, to prepare preparations for the microscope, you will need a scalpel and a cutting mat (safe, you will not scratch the table under it, it is self-healing).
On the picture - cutting mat , scalpel and a bottle methylene blue. Everything was purchased in the most ordinary (not specialized) online store.
Study of living microorganisms
Molds and yeasts are best considered alive in a “crushed drop” preparation. The cells of these microorganisms are relatively large; usually, microscopy in a living state clearly reveals their shape, size, details of the internal structure, and the nature of reproduction (budding, division, sporulation, etc.).
Bacteria are often considered dead on fixed stained preparations(due to their small size). At the same time, we get a clearer idea of the shape and size of the cells, and their ability to form spores.
Bacteria are considered alive in a “crushed drop” when their ability to move is determined. 
When microscopying yeast, a small amount of liquid is added in a loop to a drop of liquid on glass. methylene blue(until blue color) and this mixture is thoroughly stirred. Methylene blue staining of live yeast is used to identify dead cells, which easily stain blue. Living cells remain unstained because they do not allow dye to pass through their membrane.
The yeast preparation prepared on a glass slide is covered with a coverslip and examined with a 40X objective. In such a preparation, transparent oval or round yeast cells with nuclei and membranes are usually clearly visible, which are clearly visible in living yeast cells. Dead cells are usually smaller than living cells and are blue in color.
Staining yeast with methylene blue
The most widely used method for identifying dead cells is using methylene blue. After entering the cell cytoplasm under the action of reductase enzymes, this dye is reduced by living yeast cells to colorless compounds. Dead cells turn blue. The effectiveness of this method depends not only on the state of the cell membrane, but also on the activity of oxidoreductases in the cell.
Cell staining with methylene blue and safranin
More complete information about the physiological state of yeast is provided by staining fixed preparations with methylene blue, tannin and safranin. Safranin is used to identify cell nuclei that stain red. If the cells are alive and contain oxidoreductases that break down methylene blue, then the colored preparation takes on a reddish rather than purple hue.
Reagents: methylene blue dye; safranin dye; 5% solution of tannin in water; saline solution (0.9% NaCl solution). 
Place a drop of yeast suspension on a glass slide degreased with soap. Leave to air dry at room temperature. After the drop has dried, fix the preparation (pass the glass 10 times in the flame of an alcohol lamp). Do not heat too much, do not overcook. Fill the glass with methylene blue solution and leave for 4 minutes at room temperature. Rinse off the dye with warm water. Pour the glass with freshly prepared tannin solution for 2 minutes. Rinse off the dye under running water. Fill the glass with safronin solution for 16 minutes. Wash off the dye. Microscopy should be performed with non-fluorescent oil at 400x magnification.
Preparation of live bacteria
The live bacteria preparation is prepared similarly to the yeast preparation, but bacteria can be seen without adding paint. The specimen is viewed with a 90 X immersion objective, preferably in a dark field (i.e. with the aperture closed). If the bacterial culture is mobile, then rapid, varied movements of individual cells are clearly visible.
Morphology of hungry and old cells (magnification 400x).
To prepare a preparation of mold fungi, very carefully (so as not to destroy the sporulation organs) with a special needle (can be dissecting) or botanical tweezers, remove a piece of the fungal film and transfer it to a drop of water previously applied to a glass slide. The preparation is carefully, lightly pressing, covered with a coverslip and examined under a microscope with an 8X objective. With this magnification, the structure of the sporulation organs of mold fungi is clearly distinguished. For a detailed study of individual structural details (hyphae, bags, etc.), the preparation is examined with a 40X lens.
When preparing preparations in a crushed drop, you need to remember:
1. When lowering the cover glass onto the drop, you should touch its edge to the edge of the drop and, gradually tilting it, lower the glass.
2. The drop should not be large so that the liquid does not overflow the edges and does not fall on the upper side of the coverslip. Remove excess water with filter paper.
3. Single air bubbles remaining under the coverslip usually do not interfere with observation. But if there are a lot of them, it is better to prepare the drug again.
4. The preparation should not be too thick so that microorganisms do not obscure each other.
5. Prepared preparations are examined immediately after preparation (especially live bacteria), since otherwise the water dries out and bacterial cells lose their mobility.
6. The bacteriological loop (or needle) before and after each next passage (applying a drop of water to the glass, removing the culture from the agar and stirring it, taking paint, etc.) must be red-hot in a burner flame. After calcination, the loop is quickly cooled in air (held for 2-3 seconds without touching anything) and the next stage of work begins.
Morphological model of a cell.
Simple staining of preparations
When simply staining preparations, pour a few drops of some coloring solution (methylene blue, diluted fuchsin, etc.) onto a fixed smear. To obtain purer preparations, it is recommended to pour the dye solution onto a piece of filter paper that is used to cover the smear.
On average, the paint solution is kept on the smear for 2-3 minutes (depending on the type of paint):
- Fuchsin stains intensely, and all types of bacteria stain equally well. The duration of staining with a fuchsin solution is quite sufficient for 1-2 minutes.
- Alkaline methylene blue is left to stain the smear for 2-3 minutes. It colors less strongly, but the preparation is more elegant, and besides, different bacteria acquire color of varying intensities. When stained with methylene blue, large cells (for example, yeast) differentiate between the nucleus and cytoplasm.
- The gentian violet solution is kept for coloring for 3-5 minutes.
Types of dyes for preparing samples for a microscope
Staining of yeast cells with iodonitrotetrazolium chloride.
Dyes in microbiology are salts of two types: 1) acidic dyes - in which the ion that imparts color (chromophore) is an anion (for example, eosin); 2) basic dyes - those in which the role of a chromophore is played by a cation (for example, methylene blue).
Acid dyes are acidic because the chromophore, being an acid, binds to a base (NaOH) when it forms the color-giving salt.
Dyes of the second type are called basic because the chromophore, being a base, binds to an acid (HCl) when forming a salt.
Typically, acidic dyes bind more intensely to the cytoplasmic (basic) components of the cell, and basic dyes bind more intensely to the nuclear (acidic) components.
Staining methods are based on either visible (ordinary) light microscopy or fluorescence microscopy. Dyes for the light microscope are methylene blue, Lugolya solution, etc. Fluorescent dyes include magnesium salt of 1-anilino-8-naphthalene sulfonic acid (Mg-ANS), as well as dihydrorhodamine.
Staining of cells with dihydrorhodamine in the green and red spectrum.
Methylene blue is a multifunctional formula that is used by humans in various industries. This composition is used as a dye for cotton, but it is quite unstable when exposed to sunlight.
Analytical chemistry needs it as a determinant for a number of substances. The aquarium industry uses the composition as an antiseptic for breeding caviar, and water treatment uses it to check the quality of activated carbon.
The most common use of this remedy is still in medicine. It is used when poisoning occurs. It has also been proven to be highly effective in the fight against Alzheimer's disease.
Pharmacology of the drug
The formula in practice gives a disinfecting effect. The drug also participates in the redox process and supplies hydrogen ions. These properties allow it to be effective during the treatment of poisoning.
This composition is poorly soluble in alcohol and barely soluble in water (only with a balance of 1 to 30). Methylene blue itself is green crystals, but when combined with water, the solution becomes deep blue.
In what form is the drug available?
There are two types in which this product is sold:
- dark green powder;
- dark green crystal.
Methylene blue also has several other names that denote the same formula: Methylthionium chloride, methylene blue.
Although aquarium fish are very calm and quiet creatures, they, like other pets, also require special care. For them you need to buy special food, ensure that the water temperature is maintained at the required temperature, provide air access and good lighting. Particular attention should be paid to water quality. Fish cannot stay in dirty water for long and die. A sanitary conditioner called “Methylene Blue” helps.
Conditioner properties
The main advantage of Methylene blue is the use of natural (organic) dyes in its composition. The product has a number of properties useful for aquarium fish:
The product can be added to food. This ensures its soft action. The solution does not harm the process of egg incubation, but, on the contrary, promotes it.
Application
With the help of Methylene blue, you can improve the tissue respiration of fish even after oxygen starvation, for example, when the fish are transported for a long time.
Instructions for people: use of the composition
Methylene blue solution must be used strictly according to the instructions. For external use, take a solution of powder with alcohol in a ratio of 1 to 100 or 3 to 100, respectively. When working, you need to soak the bandage or cotton wool in the solution and wipe the necessary areas. The healthy tissue surrounding the diseased areas is also treated.
A very weak aqueous solution of Methylene blue (1 in 5000) is used internally with water. Adults should consume methylene blue in the amount of 0.1 grams per day in three or four doses. Children need to divide the dose into the same number of times, but reduce the amount of the substance according to age.
Before giving the drug to a child under 5 years of age, be sure to consult a doctor and clearly find out the causes of the disease.
Contraindications
Adverse reactions
After using the product, the water may change its appearance - become light blue, however, this does not interfere with the fish themselves.
Instructions: dosage
In a freshwater aquarium, you can add 20 drops (about 1 ml) of the product per 50 liters of water. However, you cannot simply drop the required dose of the drug into the aquarium. To begin with, you can mix it with a small amount of water, for example, take 100-200 ml. After mixing thoroughly, this solution can be poured into the aquarium in small portions. 5 days after disinfection, half of the water needs to be changed.
To completely remove the product from the aquarium, it is advisable to use activated carbon.
To process marine fish, they must first be placed in a separate container. The concentration of “Methylene Blue” for cold-blooded people should be as follows: 1 ml. products for 10 liters of water. The fish should stay in such an environment for about 3 hours.
Features of use
During disinfection with Methylene Blue, biofilters and activated carbon must be removed from the container.
Methylene Blue is an antiseptic drug.
Pharmacodynamics and pharmacokinetics
This product belongs to antiseptic . Its action is based on the ability of the drug to interact with certain groups of substances gram-positive bacterial cells , their proteins and mucopolysaccharides with the formation of poorly soluble and slowly ionizing complexes.
The drug has redox properties and is able to play the role of a donor of hydrogen ions in the body. Thanks to this, it can be used for some poisonings.
The drug does not enter the systemic circulation when applied topically. When taken internally, the drug is excreted through the kidneys.
In addition, this product can be used for aquarium fish. It prevents the proliferation of ichthyophthirius, trichodin, aeromonads, myxobacteria, chilodonella, costia, and pseudomonads. Methylene blue for aquarium is also used to improve acid metabolism in fish tissues, if they were transported, preparations antibacterial feed, processing of caviar and fry.
However, when using it, the water turns blue, which causes the equipment and accessories in the aquarium to get dirty and makes it difficult to monitor your pets. Therefore, it is advisable to use this product in a separate container.
Indications for use
The drug is used for burns , purulent-inflammatory diseases skin, pyoderma .
In the case of and the medicine can be used both internally and externally, including for diagnostics renal function .
Methylene blue is sometimes used for... The drug treats the affected areas of the oral mucosa. In some cases this leads to additional burns , so this remedy is rarely used today, especially in light of the fact that other effective drugs are now more popular.
Contraindications
Do not use the product if you have a negative reaction to its components. In addition, it is contraindicated in children under 1 year of age.
Side effects
Side effects of the drug include damage to kidney and bladder tissue, nausea, anemia , painful sensations in epigastric region , vomit.
When used externally, the products are possible. Moreover, the larger the area being processed, the higher the likelihood of their occurrence.
Instructions for use of Methylene Blue (Method and dosage)
The instructions for Methylene blue, when used externally, advise that patients need to lubricate the affected areas of the skin with the solution, slightly covering the surrounding healthy areas. In this case, you need to use a 1-3% solution of the drug. The areas on the body where treatment is carried out should be cleaned in advance. The solution is applied using a cotton swab.
For diseases of the urinary system, use an aqueous solution of Methylene Blue 0.02%. To do this, the drug is diluted independently.
Adults take the medicine internally in a dosage of 0.1 g 3-4 times a day. For children, doses are calculated based on age - 0.005-0.01 g per 1 year of life. Children should take the medicine at the same frequency as adults.
In case of severe poisoning carbon monoxide , hydrogen sulfide And cyanides use 50-100 ml of an aqueous solution of 1% or a solution of 1% in 25% glucose. The medicine is administered IV .
For poisoning with nitrite or aniline derivatives, Methylene Blue is used as an antidote. A 1% solution is administered intravenously at 0.1-0.15 ml/kg.
In all cases, the duration of treatment is determined individually by a specialist.
In addition, this medicine is used for aquariums. The instructions for fish provide several methods of use:
- cleaning a freshwater aquarium - add a solution at the rate of 1 drop per 2.5 liters of water, first dissolve it in 100-200 ml of water, then pour in small portions, stirring a little. After 5 days, half the water in the aquarium is replaced. If necessary, the procedure can be repeated for another 5 days. Upon completion of treatment, the water is clarified using filters with, or partially replaced;
- improvement of tissue respiration of fish - the solution is administered over 5 days at a dosage of 1 ml per 75 liters of water;
- antibacterial food - 3 drops of solution diluted with water in a ratio of 1 to 2 and mixed with 3 g of food, the mass is mixed well and dried at room temperature. Fish should receive such food for 10 days;
- processing caviar - dilute the drug at the rate of 1 ml per 50 ml of water and place caviar in such a solution for 2-3 hours;
- treatment of marine fish - the drug is added to the fish tank containing aquarium water at the rate of 1 ml of solution per 10 liters of water, after which it is mixed well and the fish are added there. They are kept in this way for three hours. This treatment should be carried out 5 times every other day.
An experienced livestock breeder, in addition to the usual medications, always has an antiseptic on hand. If attentive parents buy brilliant green for their children, then world-wise farmers buy blue for their birds. Methylene blue for chickens is a cheap drug that can surprise you with a wide spectrum of action and will help cope with many diseases.
Bacteria were the first inhabitants of planet Earth. They live in literally every corner of the planet, even in the bodies of living beings. For example, the human body contains more than 2 kg of bacteria, which are mostly harmless. However, sometimes pathogenic microbes come to visit and begin to adversely affect the functioning of cells. Antiseptics are an effective means of combating these pests.
A few centuries ago, the concept of disinfection did not intersect with medicine in any way, until the Austrian Ignaz Semmelweis discovered the connection between dirty hands and an increase in the mortality rate. With his “clean” hand, the Scot Joseph Lister invented the first antiseptic in the 19th century.
These disinfectants are actively used to heal wounds and to eliminate bacilli and fungal infections.
There are several groups of antiseptics.
| Group | Representatives |
|---|---|
| Halogen-containing | chlorine, iodine |
| Oxidizing agents | hydrogen peroxide, potassium permanganate |
| Metal compounds | preparations of bismuth, zinc, lead |
| Acids and alkalis | salicylic and boric acids, sodium tetraborate, benzoyl peroxide |
| Aldehydes | cidipol |
| Alcohols | ethanol |
| Phenols | resorcinol |
| Anionic | soap |
| Herbal preparations | marigold or chamomile flowers |
| Dyes | methylene blue, brilliant green |
Many of them have flaws that appear when used externally, such as chlorine, the pungent odor of which irritates the mucous membranes. Methylene blue, on the contrary, does not have a negative effect on the mucous membranes.
Popularity of dyes as disinfectants: green, red or blue
It is surprising how many dyes turned out to be antiseptics. Take methylene blue, for example: traditionally it was used to “turn” fabrics blue. However, he was destined for a more significant, health-improving mission.
Comparative characteristics of the pharmacological properties of antiseptic dyes
| Name | Indications for use | Release form |
|---|---|---|
| Diamond green |
| Available in the form of green alcohol solutions (1% and 2%), as well as in the form of pencils. |
| Magenta |
| Aqueous solutions turn out to be a rich red color, but the drug is not used independently, only as part of some combined antiseptics, in particular fucorcin. |
| Methylene blue |
| Available in powder and in ampoules containing 20 and 50 ml of 1% solution of methylene blue in 25% glucose solution. |
As can be seen from the table, brilliant green has the narrowest spectrum of action; moreover, recently there has been active debate about its effectiveness as an antiseptic. Blue has the largest radius of influence, the disinfecting properties of which are successfully used in the livestock sector.
Composition and release form
Methylene blue is classified as an antiseptic. In veterinary medicine it is widely used for the prevention and treatment of the following diseases:
- fungal diseases of fish;
- rheumatic diseases of horses;
- infectious diarrhea of sheep and goats.
It also demonstrated excellent performance in the treatment of bird diseases caused by various infections.
Characteristics of the drug
You can buy it at any pharmacy and it is available without a prescription.
| Appearance | Crystal granules |
|---|---|
| Solubility | Diluted in water in a ratio of 1:30, slightly soluble in alcohol. |
| Storage conditions | In a tightly closed container, in a dark place at a temperature from 150˚C to 250˚C. |
| Release form | Powder and ampoules containing 20 and 50 ml of 1% solution of methylene blue in 25% glucose solution; alcohol solution: in glass bottles of 10 ml. |
| Best before date |
|
| Compound | 10 ml alcohol solution:
|
The principle of action of blue is the ability of the active substance to form compounds with proteins of the pest cell, which helps destroy harmful bacteria.
Using methylene blue to treat chickens
Traditionally, this product is used to disinfect premises, but its range of use is not limited to this:
On damaged tissues, methylene blue creates a protective layer.
Methylene blue cannot be called a panacea that cures 100% of all possible ailments, but in a number of diseases it can become an excellent assistant, especially in combination with other remedies.
Mode of application
The drug is intended for both external and internal use.
When treating the skin with the drug, the injured areas and adjacent healthy areas are treated. Contact of liquid with mucous membranes should be avoided.
Dosage of the drug
Depending on the type of disease and method of use, the permissible amount of use of the medicine varies.
Permissible concentrations of methylene blue
| Disease | Permissible concentration |
|---|---|
| Skin lesions | Wash wounds with a 1 - 3% alcohol solution. |
| Bursitis | Inject a 2% solution into the wounds at the rate of 0.01% per 1 kg of chicken weight. |
| Urinary tract infections | Rinse with 0.02% aqueous solution. |
| Infectious gastrointestinal tract | Give with liquid in a ratio of 1:5000. |
| Poisoning by poisons | Give intravenously 0.1-0.25 ml of 1% solution per 1 kg of chicken weight. |
| Poisoning with cyanide, hydrocyanic acid or hydrogen sulfide | Give intravenously at the rate of 0.5 ml of 1% solution per 1 kg of chicken weight. |
As can be seen from the table, the main areas of use of the drug are the fight against infections and poisoning, as well as the treatment of wounds.
Side effects
The drug has virtually no contraindications, with the exception of individual intolerance, manifested in the appearance of allergic skin reactions. It is not recommended to apply the solution to mucous membranes.
Symptoms of chicken diseases and rules for their treatment
Most bird diseases are caused either by poor care and nutrition, or by the presence of infections, which often cannot be treated.
Contagious diseases of chickens and their treatment
Unfortunately, the environment contains many viruses and microbes that cause diseases in birds. If the bird's body is weakened, it will be a tasty morsel for the growth of harmful bacteria and microbes, which, when ingested, begin to multiply at tremendous speed. The main danger is that one sick bird can infect the entire flock and cause 100% death.
There are several types of contagious diseases:
- infectious;
- fungal;
- helminthic and diseases caused by the harmful effects of insects.
Infectious diseases
The most common diseases are the following:
- bronchitis;
- pasteurellosis;
- coccidiosis;
- colibacillosis;
- pullorosis;
- smallpox;
- salmonellosis;
- mycoplasmosis;
- bursitis.
Marek's disease, avian influenza and Newcastle disease are common and have no cure.
Treatment regimen for infectious diseases
| Disease | Symptoms | Treatment |
|---|---|---|
| Pullorosis |
| Antibiotic injections as prescribed by a veterinarian and mandatory disinfection of the chicken coop, possibly using methylene blue. |
| Salmonellosis |
| Enrofloxacin, neomycin, tetracycline, gentamicin, furazolidone or streptomycin, antibiotic injections, water with a small amount of potassium permanganate or methylene blue are prescribed. |
| Infectious bursitis |
| A 2% blue solution is poured into the bursa. |
| Infectious diseases of the gastrointestinal tract |
| Blue is given with drink in a ratio of 1:5000. |
| Streptococcosis |
| A course of antibiotics and disinfection measures using methylene blue are prescribed. |
| Smallpox |
| In addition to taking antibiotics, skin spots should be treated with a solution of furatsilin or methylene blue. |
| Psittacosis |
| A course of antibiotics, fortified food and drink with the addition of potassium permanganate and methylene blue in a ratio of 1:5000 are prescribed alternately. |
| Omphalitis |
| Taking antibiotics, the stomach should be lubricated with a solution of methylene blue. |
| Coccidiosis |
| A course of antibiotics, fish oil should be added to food, and a small amount of methylene blue to drink. |
| A course of antibiotics and drinking with a small amount of potassium permanganate or methylene blue are prescribed. | |
| Hemophilosis or runny nose |
| Drinking water should be diluted with a small amount of disinfectant, possibly using methylene blue. |
| Bronchitis |
| Aerosol treatment of the chicken coop in the presence of birds using antiseptics: iodine monochloride, monclavit, ASD-2, ecocide or methylene blue. |
| Colibacillosis |
| Enrofloxacin is prescribed. Add furazolidone to food at the rate of 4 g per 1 kg of mixture, and a small amount of methylene blue to water. |
| Mycoplasmosis |
| Prescribed to choose from: farmazin at the rate of 1 g per 1 l, tylosin or tylan - 0.5 g per 1 l, tilmicovet - 3 ml per 1 l, pneumotil - 0.3 ml per 1 l, enroflox 10%, enroxil 10% or enroflon 10% - 1 ml per 1 liter. Add a small amount of methylene blue to the water. |
| Pasteurellosis |
| Prescribe chloramphenicol with food 2 - 3 times a day at the rate of 60 -80 mg per 1 kg of body weight; tetracycline, doxycycline, oxytetracycline: 50 - 60 mg per 1 kg of weight; norsulfazole: 0.5 g twice a day; Spectam: 1 g per 1 liter of water; avelox: 1 g per 1 l or 2 g per 1 kg of feed; floron: 1 - 2 ml per 1 l; spelink: 1.1 g per 1 kg of weight; Add a small amount of methylene blue to the water. |
Methylene blue is practically not used as a single drug, but in combination with other drugs it is an effective assistant in the fight against ailments.
Fungal diseases
Compared to infectious diseases, fungal diseases are not so terrible. However, they should not be ignored, since they are also contagious and spread very quickly. Most of them are caused by a lack of proper cleaning of the chicken coop.
Treatment regimen for fungal diseases
Unlike aspergillosis, ringworm has no cure.
Helminthic diseases and diseases caused by the harmful effects of insects
Treatment regimen for some helminthic diseases
| Disease | Symptoms | Treatment |
|---|---|---|
| Ascariasis |
| A course of hygromycin B, carbon tetrachloride and phenothiazine is prescribed, and methylene blue is added to the water in a ratio of 1:5000. |
| Drepanidoteniasis |
| Fenasal and microsal are prescribed. Traditional methods recommend giving garlic and pumpkin seeds. Methylene blue should be added to the drink in a ratio of 1:5000. |
| Ticks |
| Treating birds with any approved insecticides: Sevin, pyrethrum or ecofils - no more than 15 g per bird. The powder should be sprayed on the surface of the feathers, and diluted with an aerosol to disinfect the chicken coop. Methylene blue can be used as a disinfection aid. |
Bedbugs, lice, worms and fleas,Of course, they are not as dangerous as infectious diseases, but in some cases, if timely treatment is not started, they can be fatal.
Instructions for use
Methylene blue 1% 25ml bottle solution for places and external use (aqueous) instructions for use
Dosage form
Transparent liquid of dark blue color.
Compound
Active ingredient: methylthioninium chloride (methylene blue) -10 g; excipient: purified water - up to 1000 ml.
Pharmacodynamics
It has an antiseptic and bacteriostatic effect due to interaction with mucopolysaccharides and proteins of microorganisms.
Pregnancy and lactation:
Can be used during pregnancy and breastfeeding.
Side effects
Individual intolerance, allergic reactions. If side effects occur, stop using the drug and consult a doctor.
Selling Features
Available without a prescription
Indications
The drug is used for burns, pyoderma, folliculitis, diseases of the urinary tract, incl. cystitis, urethritis.
Contraindications
Hypersensitivity to the components of the drug.
Drug interactions
No information available.
Mode of application
Dosage
Externally, locally. For adults and children from the moment of birth, the solution is applied with a tampon or glass rod to the affected areas 2-3 times a day until signs of the disease disappear.For cystitis and urethritis, wash the cavities with an aqueous solution of 1:5000 (0.02%) 1-2 times a day.
