Vitamin B6: strong nerves, a healthy body. Vitamin B6 tablets Vitamin b6 for children preparations

Composition and form of release. Solution for injection, 1 ampoule with 1 ml of solution for injection contains 0.05 g, 0.1 g or 0.15 g of pyridoxine hydrochloride, 10 pcs in a carton.

• pharmachologic effect
• Indications for use
• Contraindications for use
• Side effects
• Interactions with other drugs

Pharmachologic effect. Vitamin B6 (pyridoxine) regulates protein metabolism. This is due to its participation in the transport of amino acids through cell membranes. Pyridoxine increases the content of creatinine in the striated muscles, which plays an important role in the process of muscle contraction. It takes part in fat and lipid metabolism, improves the absorption of unsaturated fatty acids. With a deficiency of vitamin B6 (pyridoxine), the activity of glucose-6-phosphate dehydrogenase, one of the enzymes for the direct oxidation of glucose in the pentose-phosphate cycle, decreases. Pyridoxal-5-phosphate is part of the phosphorylase that regulates the breakdown of glycogen. Significantly affects blood formation and immunity. Vitamin B6 (pyridoxine) synthesizes erythropoiesis, leukopoiesis and hemoglobin biosynthesis; activates cellular factors of non-specific immunological reactivity of the organism. Helps to stabilize blood sugar levels, induces cells to metabolize blood glucose and resists eye damage and loss of vision due to diabetic retinopathy. Regular use of vitamin B6 reduces the level of xanthurenic acid, a dangerous chemical by-product of vitamin B6 deficiency that can cause diabetes. It is able to remove from the body the risk factor for heart disease - homocysteine ​​- an amino acid, the increased content of which in the blood leads to strokes and myocardial infarctions. In the absence of vitamin B6, the blood becomes thicker and more prone to form clots that clog arteries. In addition, pyridoxine acts as a diuretic, helping to reduce water retention in the body and, as a result, lower blood pressure. Pyridoxine improves an indicator of our immune system functioning - the number of T-cells. Plays a central role in maintaining the balance of female hormones. By helping to convert estradiol, a form of estrogen, into estriol, which is its least harmful and least carcinogenic form, vitamin B6 counteracts one of the causes of cancer in women. It should be an integral part of the treatment program for uterine fibroids, endometriosis or fibrocystic mastopathy. As a natural diuretic, pyridoxine brings welcome relief from premenstrual tension. In combination with magnesium orthophosphate, vitamin B6 (pyridoxine) minimizes the formation of calcium oxalate, the main component of most kidney stones. Promotes the production of norepinephrine and serotonin, neurochemicals responsible for feelings of well-being and good mood.

Indications for taking vitamin B6. Hypo- and avitaminosis B6 (treatment and prevention) - malnutrition, long-term infections, diarrhea, enteritis, sprue, prolonged stress, malabsorption syndrome, condition after removal of the stomach and large sections of the intestine, hemodialysis. As part of complex therapy: hypochromic and microcytic anemia, parkinsonism, sciatica, Little's disease, Meniere's disease and syndrome, neuritis (including against the background of diabetes mellitus), neuralgia, congenital pyridoxine-dependent convulsive syndrome in newborns, prevention of seizures in patients during time of taking ftivazide; preeclampsia, alcoholism, liver damage while taking ethanol and anti-tuberculosis drugs, acute and chronic hepatitis, to increase diuresis and enhance the action of diuretics. Dermatitis (including atopic and seborrheic), herpes infections (Varicella zoster, Herpes simplex), psoriasis, exudative diathesis.

Contraindications for the use of vitamin B6. Hypersensitivity. With caution. Peptic ulcer of the stomach and duodenum, coronary heart disease.

Side effects. Allergic reactions, hypersecretion of HCl, numbness, the appearance of a feeling of pressure in the limbs - a symptom of "stocking" and "gloves", a decrease in lactation (sometimes this is used as a therapeutic effect); rarely - convulsions (occur only with rapid administration).

Dosing regimen. For the treatment of sideroblastic anemia, 100 mg is prescribed intramuscularly, 2 times a week. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin. With parkinsonism - intramuscularly, 100 mg / day; per course - 20-25 injections, the course of treatment is repeated after 2-3 months, or, starting with a dose of 50-100 mg / day, daily increase the dose by 50 mg, bringing it to 300-400 mg / day, as a single injection in within 12-15 days. With depression of involutionary age - intramuscularly, 200 mg / day.
For the treatment of pyridoxine-dependent convulsive syndrome in adults - intravenously or intramuscularly, 30-600 mg; children - 10-100 mg daily.

Interaction with other drugs. Enhances the action of diuretics; weakens the activity of levodopa. Isonicotine hydrazide, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine. It goes well with cardiac glycosides (pyridoxine helps to increase the synthesis of contractile proteins in the myocardium), with glutamic acid and asparkam (increases resistance to hypoxia). Pharmaceutically incompatible with vitamins B1 and B12, in powder with ascorbic and nicotinic acids.

Storage conditions. Store vitamin B6 (pyridoxine) in a dry, cool place out of the reach of children, t° not higher than +25°C.

Manufacturer. WEIMER PHARMA, Germany.

The use of the drug vitamin B6 is only prescribed by a doctor, the instructions are given for reference!

According to scientists, which is based on their numerous studies, a modern person does not receive the necessary norm of useful substances (vitamins, minerals). We usually get these substances from food. But few modern people follow the principles of a healthy, balanced diet, preferring snacks, convenience foods and mono-diets. Hence the appearance of a deficiency of vitamins, minerals, and other essential substances.

Very often the body lacks vitamin B6. It is one of the vital elements needed for health. His daily requirement is 2.0 mg per day and no less. Vitamin B6 is involved in the synthesis of serotonin, known as the hormone of happiness. Therefore, it is often referred to as a vitamin - an antidepressant. In the presence of the required amount of B6 in the blood, a person does not lose mental balance, he often experiences joyful emotions, being in a good psycho-emotional state.

With its lack, a person suffers from insomnia, dermatitis develops on the skin, and bouts of irritability increasingly occur. Also, the deficiency of this substance has a negative effect on the liver.

Any modern pharmacy offers vitamin B6 ampoules or tablets. Each package contains instructions for this drug. But you can additionally take vitamin B6 only as prescribed by a doctor, after an appropriate medical examination. Remember that an excess of it is no less dangerous than a deficiency. But to treat the consequences of such an overabundance is much more difficult.

What are the indications for the use of vitamin B6?

First of all, the drug is prescribed in the presence of hypo- and vitamin deficiency of this particular substance. This often happens with various diets, poor nutrition. It is also indicated in the treatment of long-term infectious diseases.

The drug is effective in diarrhea, enteritis, malabsorption syndrome. It is prescribed for stressful conditions, as well as a condition after resection of the stomach, intestines. Recommended for hemodialysis.

Vitamin is prescribed as part of the complex therapy of hypochromic or microcytic anemia. Included in the treatment of Parkinson's disease, sciatica, Little's disease, neuritis and neuralgia.

Applied in the treatment of congenital pyridoxine-dependent convulsive syndrome, sometimes observed in newborns. It is prescribed as a means of preventing convulsive conditions in patients while taking ftivazid.

Assign in the complex therapy of preeclampsia, alcoholism. With liver pathologies that appeared against the background of the use of ethanol or anti-tuberculosis drugs. Often it is recommended to take it to patients with hepatitis, in order to enhance diuresis, enhance the action of diuretic drugs.

Vitamin B6 is often prescribed to cores to regulate pressure. It is advised to take in the treatment of depression.

Often, preparations with this vitamin are prescribed for skin diseases - lichen dermatitis, with frequent exacerbations of herpes and psoriasis. Assign with neurodermatitis, in the treatment of seborrhea, exudative diathesis.

Assign in the treatment of autism, epilepsy. The drug is indicated for patients with generalized anxiety.

What is the vitamin B6 medication dosage and use?

The drug in tablets is taken after meals. For prophylactic purposes, take 0.002-0.005 g per day for adults.

What is the use of vitamin B6 in injection solution?

Vitamin is administered intramuscularly:

In the treatment of sideroblastic anemia - 100 mg twice a week. At the same time, folic acid, cyanocobalamin and riboflavin are usually prescribed.

In the treatment of parkinsonism - 100 mg per day. The course of conduction is 20-25 injections. If necessary, the treatment is repeated after 2-3 months.

In the treatment of depressive conditions of involutionary age - 200 mg per day with intramuscular injection.

During the treatment of convulsive syndrome (pyridoxine-dependent):

Adults: IV or IM - 30-600 mg per day.
Children: 10-100 mg per day.

What are the contraindications for vitamin B6?

Do not prescribe an additional dose, or treatment using B6 in patients with hypersensitivity. For strict restrictions on the preparation of vitamin B6, the instructions for use call patients with peptic ulcer disease, as well as those suffering from cardiac ischemia.

What are the side effects of vitamin b6?

When using drugs - sources of this substance, allergic manifestations are possible, such as skin rashes, swelling, redness of the skin, itching. Hypersecretion of HCl may be observed. Sometimes the patient complains of a feeling of squeezing in the arms and legs. In lactating women, there is a decrease in lactation. With the rapid administration of the drug, convulsions may occur.

You will learn even more detailed information about the properties and use of vitamin B6 from the original paper instructions, which you will find in the package with the drug.

Do not self-prescribe medications. Do not risk your own health, always ask your doctor for a prescription. Be healthy!

Pyridoxine is one of the vitamins of group B. It is very important for the normal functioning of the body, because with its participation, the normalization of the work of the heart and muscles, their relaxation occurs.

Also, with a lack of this vitamin, inflammation of the middle ear, hair loss and a general deterioration in the condition of the hair can occur.

Chemical name of pyridoxine: 5-Hydroxy-6-methyl-3,4-pyridine dimethanol (has the form of hydrochloride).

The chemical formula is as follows: C8H11NO3.

Referring to the B vitamins, pyridoxine is a water-soluble substance, but insoluble in ether and fatty solvents. Under the influence of high temperatures and oxygen, it does not change its properties, but is unstable to light.

The instructions for use give an idea of ​​​​how to take a specific drug containing pyridoxine.

This substance, like other B vitamins, is contained in a lot of foods.

Products containing a large amount of this substance:

To compile the most rational menu, you should know the products containing pyridoxine and other B vitamins. The listed products contain pyridoxine in the most easily digestible form.

Pyridoxine can also be obtained by using dosage forms of this substance. Also, some medicines contain magnesium, which plays an important role in maintaining human health. Instructions for use, attached to each medicinal product, must be studied before use.

Magne B (except for pyridoxine, it includes magnesium) - this preparation contains magnesium lactate and vitamin B6, the combination of which helps to prevent and treat disorders that occur during nervous and physical overload.

This drug is available in tablets, as well as in a drinking solution in ampoules. Magnesium and pyridoxine are important substances in ensuring good health.

Magnesium is an anti-stress substance.

The absorption of this drug in tablets is quite high and therefore quite effective in use.

This drug has a positive effect on the state of the human nervous system, the quality of his sleep, as well as the condition of the hair and skin.

Pyridoxine hydrochloride - this preparation also contains vitamin B6, which is involved in the process of converting methionine, cysteine, tryptophan. This drug improves the condition of the liver and is involved in the process of histamine metabolism. The drug is also available in tablets.

Instructions for use of each drug containing pyridoxine are required for preliminary study. It indicates what dose of this remedy is recommended in each case.

The need for this substance is 2 mg per day and depends on some factors:

• With an increase in physical activity,
• during pregnancy,
• With profuse hair loss,
• With a large amount of protein in consumed foods,
• During the period of breastfeeding.

In the cases listed above, the daily need for this substance and other B vitamins increases and this must be taken into account when compiling your menu, because the dose of pyridoxine in products is different. If a deficiency of pyridoxine occurs, you should include foods containing this substance in the largest quantities in your diet.

The daily requirement for this substance may increase in accordance with the state of health.

Instructions for use makes it possible to study the daily requirement of this substance.

Some groups of people need to increase the dose of vitamin B6 consumed due to the characteristics of their work or their health status.

When is the use of vitamin B6 preparations indicated?

• Women taking contraceptives
• When the condition of the hair deteriorates,
• When there is a lot of hair loss,
• In adolescence, if there are problems with the occurrence of acne and acne on the face,
• With a quick set of extra pounds and the inability to lose them.

When a deficiency occurs, the symptoms are similar to those that appear with a lack of B vitamins.

When compiling your diet, you should consider which foods contain the most pyridoxine.

In each specific case, instructions are provided for the use of a specific vitamin B6 drug to obtain the most beneficial effect on the body.

Depending on age, the dosage and daily requirement are determined:

• Adults - from 1.6 to 2.0 mg,
• Pregnant women and women who are breastfeeding - 2.5-3.0 mg,
• Newborn children - from 0.3 to 0.5 mg,
• Adolescents - from 0.6 to 1.5 mg.

Hypervitaminosis

An overdose of this substance is possible when taking additional pyridoxine in the dosage form. In this case, there is numbness of the hands and feet. It is necessary to cancel the drug taken and conduct symptomatic therapy.

Lack of vitamin B6 can be manifested by the following symptoms:

• Irritability, depression, convulsions, insomnia;
• Dermatitis on the skin of the face, near the eyes, above the eyebrows, on the scalp, neck;
• Seborrhea, stomatitis, glossitis;
• Deterioration of the condition of the hair;
• Vomiting, nausea, loss of appetite;
• Polyneuritis of extremities, conjunctivitis;
• Toxicosis during pregnancy;
• Anemia;
• Hair loss;
• Meniere's disease;
• Trembling of the hands;
• Twitching of the eyelids;
• Chronic and acute hepatitis;
• Psoriasis;
• Leukopenia.

These symptoms are characteristic of a lack of B vitamins. By including foods rich in pyridoxine in your diet, you will ensure your good health.

It should be borne in mind that vitamin B6, like other B vitamins, is destroyed during processing, freezing and canning of foods, therefore, when compiling your diet, it should be borne in mind that foods should be less processed to preserve the maximum amount of pyridoxine in them.

When using corticosteroid hormones, complexing compounds (cuprimin, penicillamine), you should be aware that these drugs inactivate and bind vitamin B6.

Instructions for the use of such drugs indicate their interaction with vitamin B6.

During the intake of estrogen-containing drugs, a severe deficiency of pyridoxine is created.

The use of pyridoxine may lead to a decrease in the effectiveness of drugs that are used in the treatment of Parkinson's disease.

With the regular use of alcoholic beverages, the absorption of pyridoxine by the body also worsens.

Sources: />

In this article, you can read the instructions for using the drug Pyridoxine (vitaminB6). Reviews of site visitors - consumers of this medication, as well as opinions of doctors of specialists on the use of Pyridoxine in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Pyridoxine analogues in the presence of existing structural analogues. Use for the treatment of hypovitaminosis (deficiency of vitamin B6) in adults, children, as well as during pregnancy and lactation.

Pyridoxine- vitamin B6. Plays an important role in metabolism; necessary for the normal functioning of the central and peripheral nervous system. In the phosphorylated form, pyridoxine is a coenzyme of a large number of enzymes that act on the non-oxidative metabolism of amino acids (including the processes of decarboxylation, transamination). Pyridoxine is involved in the metabolism of tryptophan, methionine, cysteine, glutamine and other amino acids. Plays an important role in histamine metabolism. Pyridoxine contributes to the normalization of lipid metabolism.

Compound

Pyridoxine hydrochloride + excipients.

Pharmacokinetics

It is metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxal phosphate and pyridoxamino phosphate). Distribution is predominantly in the muscles, liver and central nervous system. Penetrates through the placenta and into mother's milk. It is excreted by the kidneys (with intravenous administration with bile - 2%).

Indications

• treatment and prevention of clinical deficiency of vitamin B6;
• peptic ulcer of the stomach and duodenum;
• hypochromic and microcytic anemia;
• parkinsonism;
• chorea;
• toxicosis of pregnant women;
• hepatitis;
• dermatitis;
• exudative diathesis;
• neurodermatitis;
• psoriasis.

Release form

Tablets 2 mg and 10 mg.

Solution for injection 5% (injections in ampoules).

Instructions for use and dosing regimen

For the treatment of vitamin B6 deficiency in adults inside - 80 mg 4 times a day. It is also possible intramuscular, subcutaneous or intravenous administration in a daily dose of 50-150 mg. The duration of treatment is determined by the type and severity of the disease.

For the prevention of vitamin B6 deficiency, a dose of 40 mg per day is used.

Side effect

• allergic reactions;
• hypersecretion of hydrochloric acid.

Contraindications

• hypersensitivity to pyridoxine.

Use during pregnancy and lactation

It is possible to use pyridoxine during pregnancy and lactation (breastfeeding) according to indications.

special instructions

drug interaction

With simultaneous use, the action of diuretics is potentiated.

Analogues of the drug Pyridoxine (vitaminB6)

• Pyridoxine bufus;
• Pyridoxine Vial;
• Pyridoxine hydrochloride.

Analogues for the pharmacological group (vitamins and vitamin-like drugs):

• D Panthenol;
• Alpha Tocopherol Acetate Vitamin E;
• Aquadetrim;
• beta carotene;
• Vitamin A Retinol;
• Vitamin B12 Cyanocobalamin;
• Vitamin B1 Thiamine;
• Vitamin B2 Riboflavin;
• Vitamin D3 Colecalciferol;
• Vitrum;
• Gerboton;
• Geriatrix;
• Dexpanthenol;
• Doppelherz Vitamin E forte;
• Brewer's yeast;
• calcium pantothenate;
• calcium folinate;
• Carnitine;
• Cocarboxylase;
• Levocarnitine;
• Multi tabs;
• Multivita plus;
• Niacin;
• Nicotinamide;
• Panthenol;
• Prenatal;
• Fish fat;
• Sana Sol;
• Ferrinat;
• Folic acid;
• cholecalciferol;
• Rosehip syrup;
• Eikonol;
• Ergocalciferol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Taking vitamin B6 in tablets in some cases is the best option for supplying the body with the necessary amount of pyridoxine, and the need for tablet preparations can arise not only when the body experiences a seasonal vitamin deficiency (that is, with hypovitaminosis), but also when increased amounts of it necessary for the treatment of various diseases.

Depending on the intended purpose, vitamin B6 may be contained in tablets without the addition of other vitamins (the so-called monovitamin preparations), or it may be included in the preparations mixed with other vitamins and minerals (multivitamin complexes). For this reason, generally speaking, vitamin preparations with pyridoxine are quite numerous and varied in composition, and their prices fluctuate considerably.

However, to solve a specific health problem, it is necessary not only to use the most suitable and effective remedy, but also to choose the right dosage, the number of tablets themselves and the frequency of their intake. We will talk about the rules for such a choice and use of tablets with vitamin B6 further ...

“I recently went to the gynecologist here, there were some problems. She prescribed several medications, including vitamin B6 tablets. They are mainly used for nerves. I don’t really like to drink chemistry, but it’s a pure vitamin, and there’s nowhere to go, you have to be treated. They are inexpensive, I bought a package of 50 tablets for 55 rubles. I drank one thing twice a day, sour taste ... "

Alena, Aktau

Preparations of pure vitamin B6 in tablets (monovitamin) can be found on sale today, for example, under the following names:

1. Vitamin B6;
2. Pyridoxine hydrochloride;
3. Barthel Drugs Vitamin B6;
4. Pyridobene;
5. Pyridoxine hydrochloride - N.S.;
6. Pyridoxine-N.S.

All of them are interchangeable, it is only important to take into account the dosage of pyridoxine in specific tablets.

But there are much more multivitamin complexes with pyridoxine. The most famous among them are:

• Polyneurin with vitamins B6 and B1;
• Milgamma and Milgamma Compositum (in the form of dragees containing B1 and B6);
• Pentovit containing vitamins B1, B3, B6, B9 and B12 (price - about 150 rubles for 50 tablets);
• Biotredin with pyridoxine and threonine (price - about 150 rubles for 30 tablets);
• Angiovit, which includes vitamins B1, B6, B9 and B12 (price - about 300 rubles for 60 tablets);
• Magnelis B6 and Magne B6 - both with magnesium and pyridoxine;
• Neurobion with vitamins B1, B6 and B12.

And also on sale there are many vitamin-mineral complexes containing in their composition, including pyridoxine (usually in the form of hydrochloride): Multi-Tabs, Vitrum, Alphabet, Complivit, Centrum, etc.

“Some drugs contain vitamin b6 along with b1 and b12, although all the instructions say that they should not be mixed, as they reduce the effectiveness of each other. I dealt with a good doctor, he explained to me that in tablets these vitamins do not seem to affect each other and are absorbed normally in the stomach, but it is undesirable to mix vitamin B6 with other B vitamins in solutions. Why, then, in Neurobion, which is in ampoules, all three vitamins are mixed - it’s not clear to me ... "

Oksana, Chelyabinsk

Since vitamin B6 (pyridoxine) in the body takes part in a huge number of metabolic reactions, its use may be required for a variety of diseases. However, most often tablets with it are prescribed for the treatment and prevention of beriberi and hypovitaminosis of various etiologies - from seasonal and dietary to those associated with chronic diseases.

Signs of such beriberi are often skin manifestations, including seborrhea, glossitis, cheilosis, as well as nervous disorders, polyneuritis, conjunctivitis, mild nausea and vomiting. However, these same disorders may indicate other pathologies, so only a doctor should make a decision on taking vitamin B6 tablets for medicinal purposes.

Vitamin B6 tablets are included in the composition of therapeutic complexes, for example, in the treatment of the following diseases:

1. Tuberculosis (as an antidote for poisoning and side effects of drugs based on isoniazid);
2. Anemia and leukopenia (to stimulate hematopoiesis);
3. Nervous diseases, including Parkinson's disease, neuralgia, radiculitis, chorea minor;
4. Hepatitis;
5. Toxicosis of pregnant women (as a means of normalizing digestion);
6. Meniere's disease (to reduce the amount of fluid in the middle ear cavity);
7. Seasickness;
8. Psoriasis;
9. Children's diathesis.

Also shown is the use of pyridoxine in tablets for childhood autism and enuresis - to enhance the effect of the main treatment. The same vitamin is used in the complex therapy of diabetes mellitus and epilepsy.

In general, based on his experience and analysis of the patient's condition, the doctor may prescribe vitamin B6 for other diseases, as well as during the recovery period after surgery.

It is allowed to carefully take multivitamin tablets or dragees containing pyridoxine hydrochloride, on their own initiative for preventive purposes. Vitamin B6 is relatively safe, and signs of hypervitaminosis can only be observed in very significant abuse of it.

Therefore, complex vitamin preparations to protect against seasonal hypovitaminosis can be used in accordance with the instructions without consulting a doctor. For therapeutic purposes, vitamin B6 should only be prescribed by a specialist.

It should be borne in mind that the standard prophylactic dose of vitamin B6 per day is 3-4 mg for adults and 2 mg for children under 12 years of age. As a rule, complex vitamin preparations are used for prophylactic purposes, which include pyridoxine in relatively small quantities.

For example, the daily requirement of a person for vitamin B6, depending on age, is as follows:

1. For children of the first year of life - 0.6 mg per day;
2. Children from one year to 3 years - 0.9 mg per day;
3. Children from 4 to 6 years old - 1.3 mg per day;
4. Children from 7 to 10 years old - 1.6 mg per day;
5. Adolescents from 11 to 14 years old - 1.8 mg per day;
6. Adolescents from 15 years and adults - 2 mg per day.

For comparison: the same Multi-Tabs B-Complex contains 15 mg of pyridoxine in each tablet, that is, this more than covers the daily requirement of an adult for vitamin B6. Indications for taking this drug are as follows: prevention of neurosis, stress, recovery period after surgery, polyneuritis, neuralgia, dermatitis, and chronic fatigue syndrome. According to the instructions, take Multi-Tabs B-Complex 1 tablet 1-3 times a day.

For various diseases (including those with already developed hypovitaminosis), only the doctor chooses the dosage of the vitamin. Usually, from 20-30 to 100 mg of pyridoxine per day is prescribed for treatment, depending on the patient's condition, the severity of the disease, the patient's age and the body's need for pyridoxine.

For example:

1. With anemia, 80-100 mg of pyridoxine are prescribed, once every 3-4 days;
2. With trigeminal neuralgia, neuritis, 300-400 mg of pyridoxine per day is taken;
3. With heart failure - 100 mg per day.

For children with certain diseases, doses are reduced in proportion to age.

Tablets of vitamin B6 (monovitamin preparations) are taken 1-2 times a day during or after meals. They can not be chewed, but be sure to drink water.

Despite the relative safety and lack of consequences in case of accidental overdoses, gross violations of the rules for taking vitamin B6 can cause quite serious consequences.

For example, in some patients, when taking large doses of pyridoxine in tablets, allergic reactions are noted (mainly in the form of skin manifestations), a feeling of squeezing in the limbs, and an increase in the acidity of gastric juice. Another known side effect of vitamin B6 is a decrease in breast milk production, although in some cases it is for this purpose that the drug is used.

When taking pyridoxine (especially large single doses), poisoning is possible with characteristic signs - nausea, tingling in the fingers and toes, and sudden changes in the emotional state. When such symptoms appear, it is necessary to drink a large amount of water, induce vomiting if possible, and then take several tablets of activated charcoal.

On a note

The diuretic effect of pyridoxine is known when the corresponding drug is taken in large quantities. This effect is generally not harmful, and sometimes the vitamin is used for it (for example, in Meniere's disease).

The main contraindications to the use of pyridoxine preparations are:

• Cardiac ischemia;
• Stomach ulcer;
• Peptic ulcer of the duodenum.

In these cases, vitamin B6 is contraindicated in any form, including tablets.

In some cases, tablets cannot be used, but pyridoxine injections may well be used - for example:

• With malabsorption in the stomach and intestines;
• During the recovery period after operations on the gastrointestinal tract;
• With low performance of the patient (for example, in the treatment of patients in psychiatric clinics or in places of detention), as well as in the absence of consciousness in the patient.

In individual cases, taking pyridoxine may be contraindicated in other pathologies. In some situations, contraindications are relevant for large doses of the vitamin, while its prophylactic dosages are quite justified. The doctor should deal with these subtleties.

Medical practice shows that taking vitamin B6 tablets is advisable only in case of urgent need, when it is associated with serious health disorders. If there is no critical need to take additional doses of pyridoxine, then in sufficient quantities for the body it can be obtained from simple and affordable foods.

For example, there is a lot of pyridoxine in:

• Meat and offal - up to 108 mcg per 100 g;
• Fish - up to 94 micrograms per 100 g (cod is especially rich in vitamin);
• Cereal grains with a shell - up to 72 mcg per 100 g;
• Walnuts - up to 68 mcg per 100 g;
• Olive oil - up to 65 mcg per 100 g;
• Bananas - up to 34 mcg per 100 g;
• Potatoes - up to 29 mcg per 100 g;
• Leafy vegetables - up to 25 mcg per 100 g.

In larger or smaller quantities, vitamin B6 is found in almost all plant and animal products, and therefore, with a balanced diet and normal functioning of the gastrointestinal tract, pyridoxine deficiency in the body, as a rule, does not occur. The intake of vitamin B6 in tablets may be required mainly for various pathologies, and therefore it should be considered in this form as a medicine.

- this is a group name of three forms of the same bioorganic compound mutually transforming into each other. Different forms of the same compound are called spatial conformations and have different names that are used to quickly and easily distinguish them in written and spoken language. However, the common name for vitamin B

is pyridoxine.

Vitamin B

is a substance that has three different spatial forms of organization of the molecule. All three of these forms have the same vitamin activity and are called vitamers B

The term "vitamer" is similar to the concept of "isomer" in organic chemistry. An isomer is a variant of the spatial orientation of a molecule of the same substance (see Figure 1).

Figure 1 - Examples of hexane isomers.

Vitamin B6 consists of three vitamers-isomers, each of which has the same vitamin activity. Vitamers are called differently - pyridoxol (pyridoxine), pyridoxal and pyridoxamine. All of these names can be used to refer to some form of vitamin B6. However, to avoid confusion, vitamin B6, on the recommendation of the International Commission on the Nomenclature of Biological Chemistry, is called pyridoxine, meaning by this name all three structural forms that have the same activity - pyridoxine (pyridoxol), pyridoxal and pyridoxamine.

In addition, vitamin B6 is sometimes called the old names - adermin or Y factor, which were given to matter several decades ago during their discovery and study of properties. Today, these names are rarely used in relation to vitamin B6, but they can still be found in some scientific and popular science publications.

In the human body, all three vitamers of vitamin B6 - pyridoxol, pyridoxal and pyridoxamine are converted into two active forms - pyridoxal phosphate and pyridoxamine phosphate. It is in the form of pyridoxal phosphate and pyridoxamine phosphate that vitamin B6 has physiological and biological effects in the human body. These names are also sometimes used in the literature to indicate that we are talking about the active form of vitamin B6.

Vitamin B

has the following physiological effects in the human body:

1. Regulation of protein metabolism;

2. Regulation of iron metabolism, its delivery to

Bone marrow

and other organs and tissues;

3. Regulates the excitability of the central nervous system.

The three listed physiological effects of vitamin B6 are at the level of each cell. Then the effect is summed up and there is a general action at the level of the whole organism. Let us consider in detail what is the essence of each physiological effect of vitamin B6, and what role they play in the maintenance and regulation of vital processes.

So, at the level of protein metabolism, pyridoxine is necessary for the mutual conversion and metabolism of amino acids that occur during the reactions of transamination, transamination, deamination and decarboxylation. It is the course of these reactions that triggers and maintains vitamin B6 at the required level. The mutual transformation of amino acids occurs in the body constantly, when it is necessary from one compound, which at the moment is quite a lot, to get another - available in insufficient quantities. Thanks to this mechanism, one amino acid can turn into another - the one that is needed right now for various protein synthesis processes. The process of converting amino acids into each other allows you to maintain a dynamic balance and prevent the occurrence of deficiency due to the conversion of another substance that is available in excess. In addition, vitamin B6 improves the absorption of amino acids from the intestines into the bloodstream and their subsequent transport to various organs and tissues.

In addition, vitamin B6 supports, activates and accelerates the conversion of dopamine to norepinephrine and glutamic and aspartic acid to succinic acid, which significantly increase the rate of energy processes in cells. This means that under the influence of vitamin B6, metabolism is accelerated, metabolism is faster, and, consequently, all cells are renewed in a shorter period of time, maintaining the youth and activity of the whole organism.

In the course of deamination reactions, the formation of acetyl coenzyme A, which is a key substance for the course of Krebs cycle. And the Krebs cycle is necessary for the synthesis of a universal energy molecule ATP (adenosine triphosphoric acid) from carbohydrates. The importance of the ATP molecule cannot be overestimated - after all, each cell uses energy in this form, and not in the form of proteins, fats and carbohydrates that come with food. Thus, in order to obtain a universal energy substrate, the cell needs to process carbohydrates, proteins and fats into ATP molecules. And vitamin B6 ensures the flow of a cascade of reactions (the Krebs cycle), during which carbohydrates are processed into ATP.

During decarboxylation reactions, gamma-aminobutyric acid (GABA) is formed from glutamic acid and serotonin from tryptophan. And gamma-aminobutyric acid and serotonin, in turn, are the main inhibitory mediators in the central nervous system. That is, under the influence of GABA and serotonin, inhibition and damping of excitation in the central nervous system occurs. And since the decarboxylation reaction, during which the formation of GABA and serotonin occurs, is regulated and triggered by vitamin B6, in this way pyridoxine regulates the excitability of the central nervous system, preventing it from becoming excessively increased. That is why, with a deficiency of vitamin B6, signs of excessive excitation of the central nervous system appear, such as a tendency to convulsions, exaltation, etc.

Finally, vitamin B6 increases the amount of siderophilin protein synthesized, which transfers iron from the intestine to tissues, including the bone marrow. Thus, pyridoxine provides the bone marrow with enough iron for hematopoiesis. And therefore, with a deficiency of vitamin B6, anemia can develop, because it is simply impossible to deliver iron to the bone marrow, where hemoglobin is formed from it, due to a lack of siderophilin protein.

Vitamin B in children

performs the same functions as in adults. That is, pyridoxine speeds up metabolism, provides energy from carbohydrates, relieves excitation in the central nervous system, starts the conversion of amino acids into each other and participates in the transport of iron, creating conditions for the synthesis of hemoglobin.

In children, the ability of vitamin B6 to ensure the conversion of amino acids into each other is of great importance, since they are necessary for protein synthesis and building muscles, bones, connective tissue, blood vessels, nerves, etc. Summarizing, we can say that active protein synthesis is necessary for a child for normal growth and harmonious physical development. And at any particular moment in time, there may be a deficiency of one or another amino acid, without which it is impossible to build a protein. And then, in the literal sense of the word, vitamin B6 comes to the rescue, which starts the process of converting one amino acid in excess into another - the one that is now lacking. That is, pyridoxine in children ensures normal physical development and full growth.

The function of maintaining protein synthesis is important not only for growth, but also for normal immunity. After all, antibodies or immunoglobulins are protein structures that are constantly synthesized in the body to destroy various pathogenic bacteria, viruses, fungi, etc. And against the background of vitamin B6 deficiency, the synthesis of immunoglobulins can occur with insufficient intensity, which will manifest itself as a decrease in immunity in the child.

Vitamin B6 is also involved in the synthesis of insulin, a protein that is very important for the utilization of glucose, with an insufficient amount of which a person develops a severe, chronic metabolic disease - diabetes mellitus.

In addition, vitamin B6 is necessary for the synthesis of a sufficient amount of hemoglobin, since it stimulates the formation of a protein that delivers iron to the bone marrow, where hemoglobin is assembled. For children, this is especially important because they grow rapidly, and their blood volume is constantly increasing. If the volume of blood increases without a proportional increase in the amount of hemoglobin, then the child will develop anemia.

Also, for children, the ability of vitamin B6 to suppress excitation and activate inhibition in the central nervous system is very important. Given the predominance of excitation over inhibition in the brain in children, it becomes clear that vitamin B6 is very important for maintaining balance and preventing convulsive activity, irritability and excitability.

Pyridoxine is also very important for skin health, since the vitamin prevents dermatitis of any origin, including allergic, seborrheic, fungal, psoriatic and diathesis. Given that children often develop inflammatory and itchy rashes on the skin, the role of vitamin B6 as a substance that prevents these phenomena is very important.

All three vitamers B

are well absorbed from the small intestine into the blood, with the current of which they enter

Where they are transformed into active forms - pyridoxal phosphate and pyridoxamine phosphate. It is in two active forms that vitamin B

exerts all its biological and physiological effects on the human body. After use, pyridoxamine phosphate and pyridoxal phosphate are converted to pyridoxic acid, which

excreted from the body in the urine.

Vitamin B deficiency

is rare, since pyridoxine is found in sufficient quantities in many foods consumed by people on a daily basis. The most common vitamin B deficiency

develops against the background of various diseases of the digestive tract, in which its absorption into the blood is disturbed (for example, malabsorption), as well as in pathologies associated with accelerated protein breakdown, such as

alcoholismhyperthyroidism

Fever of any origin or

In addition, pyridoxine deficiency can be formed in hereditary diseases such as homocysteinuria, cystationuria, xanthurenuria, pyridoxine-dependent convulsions and anemia.

Separately, it is worth mentioning the use of drugs that prevent the absorption of pyridoxine into the blood from the intestine as the reasons for the development of vitamin B6 deficiency. These drugs include anti-tuberculosis (isoniazid, ftivazid, tubazid, cycloserine) and some other antibiotics (penicillamine, chloramphenicol), as well as Ethionamide, Levodopa, estrogens and immunosuppressants.

Vitamin B deficiency

in adults, it manifests itself with the following symptoms:

• Deterioration of appetite up to its complete loss;
• Nausea and vomiting;
• Irritability;
• lethargy;
• Depression;
• Insomnia;
• severe anxiety;
• fatigue;
• Convulsions and high convulsive activity;
• Seborrheic dermatitis;
• Hair loss;
• Bloating and flatulence;
• Formation of kidney stones;
• The appearance of abnormal waves on the electroencephalogram (EEG);
• Neuritis and polyneuritis of peripheral nerves;
• Inflammation of the tongue (glossitis);
• Stomatitis;
• Conjunctivitis;
• Dryness and roughness of the skin on the face, especially around the eyes and lips;
• Vertical and deep cracks on the lips;
• Cracks in the corners of the mouth;
• Numbness of the limbs;
• muscle weakness;
• Reduced immunity by reducing the number of T-lymphocytes.

Children are deficient in vitamin B

manifested by the following symptoms:

• Delayed growth and physical development;
• convulsive attacks;
• High convulsive readiness and convulsions;
• Increased excitability;
• Disorders of the digestive tract (flatulence, diarrhea, etc.);
• Dermatitis with a pronounced inflammatory reaction.

Vitamin B

found in many foods. However, the largest amount of it is found in the following products:

• Walnuts;
• Hazelnut;
• Spinach;
• Potato;
• Carrot;
• White cabbage;
• Cauliflower;
• tomatoes;
• Strawberry;
• Sweet cherry;
• oranges;
• lemons;
• Horseradish;
• Garlic;
• Yeast;
• Sweet bell pepper;
• Pomegranate.

The foods listed above contain the maximum amount of vitamin B6. Pyridoxine is found in somewhat smaller but also sufficient amounts in legumes (beans, beans, peas, nahut, lentils), fish, meat, dairy products, liver of animals and birds, as well as cereals and eggs.
Daily intake of vitamin B6 by people of different ages

Vitamin B requirement

in children and adults is different due to the age-related characteristics of the functioning of the body. So, for children, the following daily intakes of vitamin B are accepted.

depending on age:

• Children from birth to six months - 0.1 mg per day;
• Children 7 - 12 months - 0.3 mg;
• Children 1 - 3 years old - 0.5 mg;
• Children 4 - 8 years old - 0.6 mg;
• Children 9 - 13 years old - 1.0 mg.

Adolescent females and males, as well as adult men and women, also have different requirements for vitamin B6. The daily requirements for pyridoxine for boys, girls, women and men are shown in the table.

The above are indicative average vitamin intake per day, which should be tried to be observed daily. However, if during a week a person receives less vitamin B6 from food for several days, and on other days, on the contrary, consumes it in excess, then the dynamic balance will not be disturbed due to overlap, and in general the body will not experience a lack of pyridoxine.

These norms are calculated for healthy people leading a moderately active lifestyle. However, with nerve tension, physical exertion, staying in the cold, working with chemicals and radionuclides, the need for vitamin B6 increases.

It is recommended to calculate the individual intake of pyridoxine based on the amount of protein in the diet, based on the ratio: 0.032 mg of vitamin B6 for every 1 g of protein. With dietary nutrition, the minimum sufficient intake of pyridoxine is 1 mg, and the maximum allowable is 6 mg.

In the treatment of various diseases, the dosage of vitamin B6 by some clinicians is brought up to 600 mg per day. Usually this dose is tolerated without any negative consequences. However, scientists recommend not to exceed the daily dosage of pyridoxine more than 50 mg.

Vitamin B is currently

for medical use is available in two dosage forms:

1. Tablets for oral administration;

2. Solution for injection in ampoules.

Accordingly, vitamin B6 tablets are taken orally, and the solution is administered intramuscularly, intravenously or subcutaneously. With acne, a solution of vitamin B6 is applied externally in the form of lotions and applications to the affected areas.

In addition to the two dosage forms, a vitamin B6 preparation for medical use may contain various vitamers as the active substance, such as pyridoxine hydrochloride or pyridoxal phosphate. The preparation of vitamin B6, containing pyridoxal phosphate as an active substance, has a faster therapeutic effect compared to pyridoxine hydrochloride. Otherwise, the properties of preparations with pyridoxine hydrochloride and pyridoxal phosphate are the same.

Vitamin B

mainly used to eliminate and prevent hypovitaminosis or

beriberi

And also as part of the complex treatment of various diseases of the skin, nervous system, metabolism and a number of others. In addition, vitamin B

applied in

cosmetology

to improve the condition of the skin, hair and nails.

A separate article of the use of vitamin B6 is the prevention of the development of hypovitaminosis in the treatment of tuberculosis with antibiotics. The fact is that anti-tuberculosis antibiotics consume vitamin B6 in large quantities, therefore, even against the background of its normal intake with food, a deficient state (hypovitaminosis or beriberi) may form after a while. Therefore, when using anti-tuberculosis antibiotics, it is necessary to additionally take vitamin B6. Currently, many new anti-tuberculosis drugs are produced in a combined form that includes an antibiotic and vitamin B6. This combined form allows only one drug to be taken and eliminates the need for additional and separate use of pyridoxine.

Today, the following conditions are common indications for the use of vitamin B6:

• Early toxemia of pregnancy with nausea and frequent vomiting;
• preeclampsia;
• Newborns on artificial feeding, produced not by balanced specialized infant formulas, but by donor milk or milk of farm animals;
• Newborns on artificial feeding, suffering from dryness, swelling and peeling of the skin;
• Newborns with low body weight (hypotrophy);
• Newborns with pyridoxine-dependent convulsive syndrome (hereditary disease);
• Anemia, combined with a high concentration of iron in the blood (hypochromic microcytic anemia);
• People with low resistance to various infectious diseases;
• People with increased excitability;
• People of any age, including children, suffering from febrile seizures (convulsions that develop in response to high body temperature);
• As part of the complex therapy of heart failure;
• As part of the complex therapy of hepatitis and cholecystitis;
• As part of the complex therapy of parkinsonism;
• As part of the complex therapy of sciatica;
• Peripheral neuritis;
• Neuralgia;
• Prevention of seizures during the course of Ftivazid;
• Prevention of hypovitaminosis during the course of treatment with anti-tuberculosis antibiotics;
• Malnutrition;
• Long-term infectious diseases;
• To replenish the loss of vitamin B6 in diarrhea;
• Enteritis (for the prevention of hypovitaminosis against the background of impaired absorption of pyridoxine through the inflamed intestinal wall);
• Prolonged stress;
• Malabsorption syndrome;
• Conditions after removal of the stomach or part of the intestine;
• Hemodialysis;
• Little's disease;
• Meniere's syndrome;
• Alcoholism;
• Dermatitis (atopic, seborrheic, acne, pimples, etc.);
• Herpetic infections (herpes simplex, chickenpox, etc.);
• Psoriasis;
• Diathesis.

As you can see, the indications for the use of vitamin B6 are quite diverse, due to the physiological effects of pyridoxine, which are exerted literally on every cell of any human organ. That is why vitamin B6 preparations are indicated for use in such different conditions and diseases. Of course, with the help of vitamin B6 alone, serious diseases cannot be cured, but its use helps to increase the effectiveness of the therapy and, consequently, improve the prognosis and course of the pathology.

Currently, a solution of pyridoxine hydrochloride of various concentrations is produced in ampoules. The solution is sterile and ready for use. For ease of use, the solution is marked not by the percentage of pyridoxine hydrochloride, but by the amount of active substance in 1 ml. Vitamin B solutions are now available

two concentrations - 50 mg of pyridoxine hydrochloride in 1 ml and 10 mg in 1 ml.

A solution of vitamin B6 in ampoules is produced and sold under the following commercial names:

• Pyridoxine (vitamin B6);
• Pyridoxine Bufus (Vitamin B6);
• Pyridoxine-Vial (Vitamin B6).

In addition to these monocomponent preparations, there is a fairly wide range of multicomponent preparations, which include several vitamins, including B6. These vitamins will be listed in a separate section.

Vitamin B tablets are now available

sold under two commercial names:

• Pyridoxine hydrochloride;
• Pyridoxine (vitamin B6).

In addition, vitamin B6 is contained in a dietary supplement - brewer's yeast autolysate. This dietary supplement is standardized, the amount of vitamins in it is accurately dosed, and their clinical effects are very pronounced. Therefore, both pharmacological preparations and dietary supplements can be used as a source of vitamin B6.

These drugs are monocomponent, that is, they contain only one active substance - vitamin B6. In addition to these monocomponent preparations, there is a wide range of complex products containing several vitamins, including B6. The list of complex products containing vitamin B6 in the composition will be reflected in a separate section.

Currently, there are complex preparations of vitamins intended for treatment and prevention, containing several active substances at the same time, including B

These complex drugs can be divided into two large groups - preventive and therapeutic. Prophylactic preparations are vitamin-mineral complexes intended for periodic intake by healthy people 2-4 times a year, and contain most of the 13 vitamins and several minerals. Examples of such complexes are

VitrumCentrumSupradin

Alphabet, Multi-Tabs, etc. These preparations contain vitamin B

However, in addition to it, the composition includes more than a dozen components. And since the drugs are taken to prevent vitamin and mineral deficiencies, they are assigned to the appropriate group.

Therapeutic preparations of vitamins contain several components - from two to five. Moreover, these components are selected for compatibility with each other and ease of use. For example, complexes of vitamins B6 + B12, which are very convenient to use, since they allow you to enter both compounds at once in one injection. Such complexes contain vitamins in rather large, therapeutic dosages and are used as part of the complex therapy of various diseases. That is why they are called therapeutic drugs. Below is a list of complex therapeutic drugs containing vitamin B6:

• Angiovit (B6, B12 + folic acid);
• Binavit (B6, B1 and B12 + lidocaine);
• Biotredin (B6 + amino acid threonine);
• Vitagamma (B6, B1 and B12 + lidocaine);
• Vitaxon (B6, B1 and B12 + lidocaine);
• Combilipen (B6, B1 and B12 + lidocaine);
• Compligam B (B6, B1 and B12 + lidocaine);
• Lysobact (B6 + lysozyme);
• Magvit (magnesium citrate + B6);
• Magne B6 (magnesium + B6);
• Magnelis B6 (magnesium lactate + B6);
• Magnesium plus B6 (magnesium lactate + B6);
• Medivitan (B6, B12 and folic acid);
• Mexi B6 (B6 + ethylmethylhydroxypyridine succinate);
• Milgamma (B6, B1 and B12);
• Milgamma compositum (B6 and B1);
• Multi-Tabs B-complex (B1, B2, B3, B5, B6, B12 + folic acid);
• Neurogamma (B1 and B6);
• Neurobion (B6, B1 and B12);
• Neuromultivit (B6, B1 and B12);
• Pentovit (B1, B3, B6, B12 + folic acid);
• Pitzian (B6 and B12);
• Polyneurin (B6 and B1);
• Trigamma (B6, B1 and B12 + lidocaine).

Vitamin B

can be injected or taken orally. Injections can be given intramuscularly, intravenously or subcutaneously. Injection of vitamin B

it must not be mixed with

Because they are incompatible. B vitamins

need to prick on different days. However, vitamin B tablets

You can combine, because with this method of reception they are compatible.

The choice of method of administration of vitamin B6 depends on what the drug is used for. So, for the treatment of moderate hypovitaminosis or its prevention, as well as to improve the condition of the skin, hair and nails, vitamin B6 is recommended to be taken in the form of tablets. To eliminate severe hypovitaminosis or beriberi, as well as in the complex treatment of various diseases, vitamin B6 is recommended to be used in the form of injections. Also, vitamin B6 must be injected if a person suffers from inflammatory or ulcerative diseases of the digestive tract, in which normal absorption of the drug from the intestine is impossible.

The choice of injection route (intravenous, intramuscular or subcutaneous) is based on the capabilities of healthcare professionals and patients. The drug begins to act most quickly when administered intravenously, which must be used in acute conditions. In the treatment of chronic pathologies, if a person cannot attend a medical facility for intravenous administration of vitamin B6, he needs to switch to intramuscular or subcutaneous injections at home.

Intravenously, subcutaneously or intramuscularly, a ready-made solution is administered at a dosage of 50-100 mg per day for adults and 20 mg for children. Daily dosage of vitamin B

divided into two injections, which are given in the morning and in the evening. Precise dosage of vitamin B

determined by the type of disease:

• Therapy with anti-tuberculosis antibiotics - administer vitamin B6 at 5-10 mg per day during the entire course of treatment;
• Sideroblastic anemia - 100 mg per day, intramuscularly twice a week;
• Parkinsonism - 100 mg per day, intramuscularly twice a week. The course of treatment consists of 20-25 injections. Repeated courses are carried out after a break of 2 - 3 months.
• Depression - 200 mg per day, intramuscularly.

The duration of vitamin B6 therapy for adults is one month, and for children - two weeks. Exceeding the indicated periods of treatment is not recommended, as this can lead to the development of severe allergic reactions. If the goals of treatment have not been fully achieved within one full course, then a break for a month should be taken, after which a repeated therapy with vitamin B6 should be carried out. Repeated courses of treatment with intervals between them of at least one month can be repeated for an unlimited period of time, provided that the person tolerates the drug well.

Intramuscular injection is recommended to be done in the lateral surface of the upper third of the thigh, and not in the buttock, since an injection into the muscles of the leg is much safer. To make an injection, it is necessary to free the outer surface of the upper third of the thigh from clothing, wipe the skin at the injection site with an antiseptic (alcohol, chlorhexidine, etc.), then gently break off the tip of the ampoule with the solution, insert the tip of the syringe needle into it and draw the right amount of the drug. Then turn the syringe upside down with the needle up and lightly tap on the surface of the tube in the direction from the piston to the needle so that air bubbles break away from the walls and collect on the surface of the solution. Then lightly press the plunger and release a few drops of the drug from the needle. After that, with a quick and gentle movement, insert the needle deep into the muscle, placing it perpendicular to the surface of the skin of the thigh. Slowly pressing the plunger, inject all of the medicine into the muscle, then gently withdraw the needle, keeping the syringe still perpendicular to the skin surface. Wipe the injection site with an antiseptic.

Subcutaneous injection is best done on the forearms of the hands. Before the injection, wipe the skin with an antiseptic and draw the medicine into the syringe. Release a drop of solution from the syringe to remove air, and close the needle with a cap. Put the finished syringe on a clean surface so that it can be reached by hand. Then, with your left hand, fold a skin area of ​​1-1.5 cm into a fold and hold it in this way until the end of the injection. Take the syringe with your right hand, remove the cap and insert the needle under the skin fold, holding it parallel to the forearm bone. Slowly inject the entire volume of the solution and remove the syringe, continuing to hold the skin fold with your left hand. After the needle is removed, you can let go of the skin and wipe the injection site with an antiseptic.

It is not recommended to do intravenous injections on your own, because without the proper skill it is dangerous and painful. For intravenous administration of vitamin B6, you should use the services of a professional nurse.

Pyridoxine tablets should be taken after meals, without chewing and with a small amount.

For the prevention of hypovitaminosis, adults are recommended to take 2-5 mg per day, and children 2 mg per day. For the complex treatment of various diseases, vitamin B

it is necessary to take 20 - 30 mg per day. Daily dosage of vitamin B

can be taken once or divided into two doses - in the morning and in the evening. Duration of prophylactic and therapeutic intake of vitamin B

is 1-2 months for adults and children.

Vitamin B6 for hair

Vitamin B

for hair is very important, because it strengthens, prevents and prevents them

dropping out

With a vitamin deficiency, the hair falls out, the scalp becomes inflamed, appears

Vitamin B solution

at a concentration of 50 mg / ml with a volume of 1 ml is added to a prepared homemade or purchased hair mask and the mass is thoroughly mixed. This amount of solution is added to the amount of mask that will be used for one application to the hair. Each time before using the mask, add 1 ml of vitamin B solution to it.

At the same time, you can cook or buy any masks that seem useful to you.

Vitamin B6 (pyridoxine) - a water-soluble vitamin of group B, poorly soluble in fats. Relatively stable at high temperatures, decomposes under the influence of light and oxygen. It is not synthesized in the body, sources of intake are food and pharmacological preparations.

Benefits of taking pyridoxine:

• The enzyme transaminase is released, which is necessary for the processing of amino acids and the regulation of protein digestion.
• Under stress, the production of biogenic amines increases.
• Improves the bioavailability of fatty acids.
• The rate of biochemical reactions is increasing.
• Reducing the synthesis of oxalic acid reduces the risk of development and recurrence of urolithiasis.
• Converts folic acid to its active form.
• Dermatological diseases are prevented.
• Thanks to the lipotropic effect, the functioning of the liver improves.
• Reduces premenstrual pain.

VitaminB6 has a positive effect on such systems and organs

Nervous:

• Increases metabolism in the brain, improves memory.
• Neurotransmitters are actively synthesized - serotonin, gamma-aminobutyric acid, dopamine and norepinephrine.
• The supply of the nervous tissue with nutrient substrates improves.
• Prevents and eliminates spasms and muscle tremors.

Cardiovascular:

• Ischemia, atherosclerosis and myocardial infarction are prevented, blood is thinned and blood pressure is reduced.
• The content of potassium and sodium in the blood and intercellular fluid is normalized.
• Reduces swelling of the face and limbs in chronic heart disease.
• Necessary for the synthesis of hemoglobin, reduces blood cholesterol, prevents thrombosis.
• Normalizes the work of the heart and increases its ability to relax during diastole.

Endocrine:

• The use of glucose becomes more efficient, its level in the blood changes without sharp jumps and drops.
• Maintains the balance of estrogen, preventing the appearance of tumors in women.
• Essential for the synthesis of most hormones.
• Contributes to the preservation of vision in diabetes mellitus.

Vitamin B6 instructions for use

Injection: administered subcutaneously, intramuscularly or intravenously slowly, 1-2 times a day. When administered intravenously, a single dose is diluted with 1-2 ml of water for injection or isotonic sodium chloride solution immediately before use.

Tablets: taken orally with a small amount of liquid, regardless of food.

Buy Vitamin B6 with Potassium and Magnesium

With a lack of pyridoxine in the body, the hair dries out, breaks and splits. The scalp becomes oily, dandruff appears, hair grows poorly. Vitamin B6 has gained wide popularity among cosmetologists to eliminate such problems.

After its application:

• Dry hair is hydrated due to the fact that vitamin B6 retains water.
• Increases hair growth.
• Due to the sedative effect, itching of the skin is eliminated.
• Hair stops falling out, thickens and strengthens.
• Eliminates dandruff.
• The blood supply to the roots improves, the hair becomes smooth, increases in volume and begins to shine.

The most popular masks with pyridoxine from ampoules. They must be applied to unwashed hair, covering the head with polyethylene and wrapping it in a thick towel. With significant hair loss, masks should be applied every other day, with a preventive purpose - 2 times a week.

The most common mask recipes:

• Heat 2 teaspoons of burdock oil in a water bath and mix with an ampoule of pyridoxine. Apply to damp hair and leave on for 2 hours.
• Beat the chicken egg and mix with a tablespoon of almond oil. Add 1 ampoule of pyridoxine and vitamin B12, mix and apply overnight to dry hair. Leave for an hour, rinse with warm water and go to bed. Wash your hair with shampoo no earlier than after 8 hours.
• Melt 2 tablespoons of honey, and add 1 ampoule of vitamins A, E, B6 and B12. Stir and pour into the mixture a teaspoon of sunflower oil and lemon juice. Apply for an hour, then wash your hair with shampoo.

During pregnancy, the body's need for pyridoxine increases by 1.5-2 times. It is prescribed in combination with magnesium, which increases the absorption of both elements (Magne B6). Pyridoxine eliminates morning sickness and leg cramps in the last trimester of pregnancy.

Indications for use are:

• The threat of abortion.
• exfoliation of the placenta.
• Increased tone of the uterus.
• Spasms of skeletal muscles.
• Severe pregnancy and complicated childbirth in history.
• Frequent stress.
• Tachycardia.
• Arrhythmia.
• Hypertension.

Vitamin B6 for children

Lack of pyridoxine in the diet in children can cause severe pathologies in the development of the nervous system. With its deficiency, the child does not sleep well, suffers from night cramps. For babies, it is important that the mother gets enough vitamin B6. Before giving the drug to children under the age of one year, a pediatrician's consultation is necessary.

In a day of vitamin B 6 you need:

• Infants up to 6 months - 500 mcg.
• Infants from 6 months to a year - 900 mcg.
• Children from one year to 3 years - 1 mg.
• Children 3-6 years old - 1.3 mg.
• Children 6-10 years old - 1.6 mg.
• Boys 10-14 years old - 1.8 mg, girls - 1.6 mg.
• Boys 14-18 years old - 2 mg, girls - 1.7 mg.
• Men 18-60 years old - 2.2 mg, women - 1.8 mg.
• Men over 60 years old - 2.5 mg, women - 2 mg.
• Pregnant women - 3 mg, lactating women - 3.4 mg.

Increasing the dose by 25-30% is necessary:

• While taking birth control pills and medicines containing estrogen.
• In the last week of pregnancy.
• A week before the start of menstruation.
• While taking drugs based on steroids.
• With excess weight.
• With acne and inflammatory skin diseases.

Pyridoxine is prescribed for:

• B6-hypovitaminosis.
• Anemiah.
• Toxicosis during pregnancy.
• Reducing the level of leukocytes.
• Meniere's disease.
• Motion sickness in transport and seasickness.
• Inflammation in the gallbladder and liver.
• Parkinsonism, neuritis, radiculitis and neuralgia.
• Neurodermatitis, psoriasis and diathesis.
• diabetes mellitus.
• Edema of cardiogenic origin.
• Deterioration of contractility of the heart.
• High blood pressure and risk of myocardial infarction.
• Depression and increased nervous tension.
• Urolithiasis.
• Obesity.
• Atherosclerosis.
• Decreased immunity.
• Visual impairment due to diabetes.
• An increase in hematocrit.
• Hypercholesterolemia.

assimilation

With intramuscular injection, the bioavailability of pyridoxine is 100%. In food, it is found in the form of compounds that break down in the small intestine. With the blood, vitamin B6 enters the liver, where it is dephosphorylated, and then phosphorylated. The maximum concentration is observed in the liver, kidneys and myocardium.

Where is vitamin B6 found in animal products:

• Fillet of tuna, mackerel and sardine.
• Chicken and beef liver.
• Chicken fillet.
• Eggs.
• Shrimps and oysters.
• Beef and lamb.
• Dairy products.

herbal products:

• Hazelnuts, pine nuts and walnuts.
• Beans.
• Potato.
• Sea buckthorn and pomegranate.
• Horseradish and garlic.
• Bulgarian pepper.
• Green peas, soy and lentils.
• Bananas.
• Millet.
• Yeast.

Pyridoxine deficiency is characterized by:

• Excessive irritability, lethargy and mental dysfunctions.
• Insomnia and a feeling of unreasonable anxiety.
• Decreased appetite and developmental delays in children.
• Convulsive syndrome.
• flatulence.
• The formation of uroliths in the kidneys and bladder.
• Abnormal electroencephalogram readings.
• Peripheral neuritis, polyneuritis of the hands and feet.
• The development of anemia with a sufficient amount of iron in the body.
• Inflammation of the skin and mucous membranes.
• Stomatitis, rhinitis and conjunctivitis.
• Glossitis and ulceration of the oral cavity.
• Severe bleeding gums.
• Convulsive conditions in children under 7 years of age.
• Increased blood viscosity and its tendency to form clots that clog blood vessels and cause thrombosis.
• Nausea and vomiting.
• The inability of the immune system to synthesize antibodies.

Overdose

Vitamin B6 is rapidly metabolized and excreted in the urine. Exceeding dosages by 50 times for several years does not lead to a deterioration in health.

Increasing the dose hundreds of times can lead to:

• Peripheral blood flow disorders.
• Tachycardia and pain radiating to the left arm.
• Migraines, drowsiness and dizziness.
• Excitation and impaired coordination.
• Paresthesia of the arms and legs.
• The emergence of a feeling of pressure on the limbs (syndrome "stocking and gloves").
• Difficulty breathing.
• Anaphylaxis, urticaria, itchy rash, skin redness, dermatitis, Quincke's edema and photosensitivity.
• Nausea and vomiting.
• Deterioration of the immune system resistance against infections.
• Heartburn and increased production of gastric juice.
• Decreased folic acid content.
• Partial baldness.
• Disorders in the blood coagulation system.
• Fainting and convulsive syndrome with the introduction of large doses intravenously.
• Inhibition of milk production in nursing mothers.

Prolonged overdose causes a decrease in the amount of protein in skeletal muscle, liver, kidneys and heart.

Vitamin B6 in ampoules – price 11 UAH / 35 rubles for 10 ampoules of 1 ml.

Compound: pyridoxine hydrochloride - 0.05 g, water for injection - up to 1 ml.

Vitamin B6 tablets – price 9 UAH / 28 rubles for 10 tablets.

Compound:

• Active ingredient– priridoxine hydrochloride 0.05 g.
• Additional components: microcrystalline cellulose, lactose monohydrate, colloidal anhydrous silica, talc, magnesium stearate.

The following drug interactions have been described:

• When taken simultaneously with diuretics, pyridoxine enhances their effect.
• Combined administration with hormonal contraceptives, cycloserine, penicylamine, isoniazid, hydralazine sulfate, ethionamide and immunosuppressants reduces the effectiveness of vitamin B6.
• Pyridoxine partially blocks the action of drugs for the treatment of Parkinson's disease and weakens the pharmacological effect of phenytoin.
• When combined with corticosteroid hormones, the content of pyridoxine in the body decreases.
• Simultaneous use with glutamic acid and asparkam increases the resistance of the brain to hypoxia.
• The parallel use of vitamin B6 and cardiac glycosides stimulates the production of contractile proteins in the heart muscle.
• Pyridoxine prevents complications from taking tricyclic antidepressants caused by their anticholinergic action (decreased salivation, anuria).
• Simultaneous administration with derivatives of chloramphenicol reduces the risk of ophthalmic pathologies.
• Vitamin B6 is compatible with vitamin B12, but mixing them in one container is not recommended.
• It is undesirable to mix pyridoxine with alkali solutions, iron derivatives and solutions of strong oxidizing agents.
• You can not mix vitamin B6 in the same container with solutions of adrenomimetics, ampicillin sodium salt, amphotericin B, ascorbic acid, phytomenaion, dipyridamole, sodium oxyferiscorbone, phenothiazine derivatives (chlorpromazine), furosemide, etamsylate and eufilin.

Pyridoxine is vitamin B6 in tablet or injectable form.

Strictly speaking, vitamin B6 is represented by three different vitamers, passing one into another - pyridoxine, pyridoxal and pyridoxamine, but only one of them, pyridoxine, is used as a drug.

Although by and large this is not so important: in any case, when passing through the liver, all pyridoxine vitamers are converted to pyridoxal, which, in turn, is phosphorylated to form pyridoxal phosphate.

Vitamin B6.

Released without a doctor's prescription.

How much does Pyridoxine cost in pharmacies? The average price is at the level of 50 rubles.

Dosage forms of Pyridoxine:

• Solution for injection (1 or 2 ml in an ampoule, in a blister pack 5 ampoules, in a carton pack 1 or 2 packs complete with an ampoule knife; in a blister pack 10 ampoules, in a carton pack 1 or 2 packs complete with a knife ampoule; in a cardboard box 10 ampoules complete with an ampoule knife).
• Tablets: flat-cylindrical, white, with a risk and a bevel, slight marbling is possible (50 pcs in a jar of light-protective glass or in a polymer jar, in a carton pack 1 jar; 50 pcs in a polymer bottle, in a carton pack 1 bottle, allowed also production of polymer jars and bottles without packs, 10 pcs in a blister pack, in a carton pack of 1, 2, 3, 4 or 5 packs, 10 pcs in blister packs placed in a group package).

Active ingredient: pyridoxine hydrochloride - 10 mg in 1 tablet; 10 or 50 mg in 1 ml of solution.

An additional substance in the solution is water for injection.

Pyridoxine normalizes the functioning of the central and peripheral nervous system, participates in the metabolism of aminocarboxylic acids: glutamic, tryptophan, methionine and others. Vitamin b6 contributes to normal lipid metabolism.

The use of Pyridoxine will help start the body's metabolic processes by converting the active substance into pyridoxal-6-phosphate. This compound is a coenzyme substance that activates the enzymes necessary for the normal metabolism of amino acids and lipids.

Pyridoxine tablets used for the treatment and prevention of hypo- and avitaminosis B6.

As part of complex therapy, Pyridoxine is recommended for use in the following diseases:

1. Damage to the nervous system (Ménière's syndrome, neuralgia);
2. Toxicosis of pregnant women (sideroblastic, microcytic and hypochromic anemia);
3. Hepatitis in acute and chronic form.
4. Seborrhea-like and non-seborrheic dermatitis, herpes zoster, neurodermatitis, psoriasis, exudative diathesis and other dermatological diseases.

Injection used for the prevention and treatment of hypo- and avitaminosis B6 (prolonged infectious diseases, malnutrition, malabsorption syndrome, enteritis, diarrhea, sprue, prolonged stress, condition after removal of the stomach and large sections of the intestine, hemodialysis).

As part of combination therapy, the drug is used to treat congenital pyridoxine-dependent convulsive syndrome in newborns.

The presence of hypersensitivity to the components of the drug is a contraindication to the use of Pyridoxine.

In patients with peptic ulcer of the stomach and duodenum and coronary heart disease, caution should be exercised when prescribing the drug.

Despite the fact that vitamin B6 is necessary for women during pregnancy and lactation, Pyridoxine can be used in this situation only as directed by a doctor.

The instructions for use state that Pyridoxine tablets are taken orally after meals. They are not chewed and washed down with a sufficient amount of water. The average dosage of the drug for the treatment of vitamin B6 deficiency in adults is 80 mg 4 times a day, for the prevention of hypovitaminosis - 40 mg per day.

For complex treatment of various pathologies, the doctor selects the dose of the drug individually.

The injection solution is also used for the treatment and prevention of beriberi or hypovitaminosis of vitamin b6. Additionally, water for injection is used. In pharmacies, the drug is sold strictly by prescription. The solution is administered intramuscularly, subcutaneously or intravenously. For adults and children, the daily dose is prescribed individually, depending on the severity of the condition.

The daily requirement of the child is up to 20 mg. Adults are recommended 100 mg / day, but you can assign up to 600 mg / day (convulsive syndrome), a course of up to 25 days.

The use of both dosage forms of the drug, in accordance with the annotation, in rare cases may be accompanied by: allergic reactions (skin rash, urticaria), increased stomach acidity, abdominal pain, a feeling of tightness in the limbs, and decreased lactation.

There are no data on overdose with Pyridoxine tablets to date.

Use with caution in gastric ulcer and duodenal ulcer, coronary artery disease.

In severe liver damage, pyridoxine in high doses can cause a deterioration in its function.

When using the drug, it is necessary to take into account the interaction with other drugs:

1. With simultaneous use, it potentiates the action of diuretics.
2. With simultaneous use with levodopa, the effects of levodopa are reduced or completely inhibited.
3. With simultaneous use with hormonal contraceptives, an increase in the concentration of pyridoxine in the blood plasma is possible.
4. With simultaneous use with isonicotinhydrazide, penicillamine, cycloserine, a decrease in the effectiveness of pyridoxine is possible.
5. With simultaneous use with phenytoin, phenobarbital, a decrease in plasma concentrations of phenytoin and phenobarbital is possible.
6. The physiological function of vitamins B1 and B6 is the potentiation of each other's action, which manifests itself in a positive effect on the nervous, muscular and cardiovascular systems.

We picked up some reviews of people who used vitamin B6 Pyridoxine:

1. David. I was prescribed this vitamin due to numbness and tingling in my legs and arms. Has passed or has taken place two courses of treatment. Since after the first, not everything returned to normal. The numbness and tingling went away gradually. True, during the second course there was a small rash on the neck. I don't know if it was a side effect of pyridoxine. But he helped me.
2. Lisa. Vitamin B6 was prescribed for anemia along with iron preparations. No preliminary analyzes were done. And such treatment with a finger in the sky hit the mark, hemoglobin increased. After the course of treatment with vitamin and iron, it no longer fell.
3. Angela. I tried to take a group of vitamins in tablets at the same time, it seemed to me more effective and more convenient, but there was no effect and the expected result. I decided to try each group separately. I started with B6, felt relief, pain decreased. Since I have a disease of the nervous system, constant neuritis and neuralgia, I have to take a mandatory course once a year, but this is not at all difficult, and even more so since I learned to inject myself. The pains have decreased a lot, but the main thing is to prevent exacerbation, otherwise you have to take a full course, and it’s enough to pierce for prevention.

Structural analogues for the active substance:

• Pyridoxine bufus;
• Pyridoxine Vial;
• Pyridoxine hydrochloride.

Before using analogues, consult your doctor.

Pyridoxine should be stored, according to the instructions, in a cool and dry place protected from sunlight. Shelf life - 36 months.

Greetings, my inquisitive readers. Today we have a special guest with you - this is the “vitamin of life”. Yes, yes, you heard right. Without this element, the origin of life, its development and flow is unthinkable. What is this miracle cure? It is pyridoxine or vitamin B6.

I learned about the magical properties of this element when my son was 1 month old. And we planned to go to see a neurologist.

The fact is that during childbirth there was hypoxia. The first month for my husband and I was a real hell. Antoshka often shouted, slept very badly. I fell asleep and woke up 20 minutes later. They walked like zombies. I just wanted to sleep.

We were advised a good neurologist, and we went to see him. He examined the baby with such care. He asked about his son - about sleep, how he eats and so on. It turned out that there is a tremor and the neck mows to the left.

And then he prescribed glycine (a common amino acid) + magnesium B6 for half a tablet. Found that it is still sold in liquid form in ampoules. So we decided to give them to Antokha. After 4 days began to observe changes in behavior. Sonny after eating began to sleep for an hour, became more calm. A week later, he began to sleep through the night without waking up to eat. He wakes up on his own, examines toys, can play alone. And how he floundered in the water - he filled the whole bath.

And what impressed me was the effect of this miracle remedy. After the cancellation, the action continued anyway. I myself write and knock on wood so as not to jinx it. And then I brag to you 🙂

fell asleep while I was collecting it for a walk 🙂

Seeing such a magical effect of the vitamin on my son, I decided to find out more about B6. It turns out that this element is simply priceless - absolutely everyone needs it.

Why does the body need vitamin B6?

Pyridoxine belongs to the B vitamin family. These compounds play an important role in a number of physical and psychological functions. They are known to help maintain a healthy metabolism and the functioning of the nervous system. And such elements are also important for the health of the skin and eyes, the normal functioning of the liver.

Pyridoxine has several derivatives, including pyridoxal phosphate, pyridoxal-5-phosphate, and pyridoxamine. These important substances are involved in various biological functions of the body.

Vitamin b6 is involved in the following processes:

• supports the nervous system
• helps produce hemoglobin, which carries oxygen in red blood cells (erythrocytes) throughout the body
• balances blood sugar levels;
• helps to get energy from the food we eat;
• improves mood;
• creates antibodies that the immune system uses to protect us;
• important for hair - strengthens them and accelerates growth.

Deficiency symptoms

B6 deficiency is extremely rare in Western countries. Most people get enough calories and vitamins from food every day. Some experts even believe that some consume too high levels of pyridoxine altogether. Therefore, its excess is an even more common problem among the population than its deficiency.

With such an amount of an element, the body can easily replenish from its diet. But if you are over 50, then the dosage of b6 should be increased to 2.2 mg per day. Otherwise, the body will begin to experience a shortage.

As I said, friends, the deficiency of this vitamin is not very common. However, this problem still exists. The following symptoms help to judge the lack of element B6:

• mood changes (irritability, anxiety and depression);
• lethargy;
• muscle pain;
• chronic fatigue;
• exacerbation of PMS symptoms;
• worsening symptoms of anemia;
• insomnia;
• convulsions;
• dermatitis and yellow-lemon shade of the skin;
• deterioration of the cardiovascular system.

Most often, vitamin B6 deficiency is associated with neuropsychiatric disorders. Recent studies have shown that deficiency of this element is usually common among older people. They are at greater risk of developing Alzheimer's and other forms of dementia as B6 levels decrease.

Where is contained

This element is found in many foods that we eat. These are nuts and seeds, some types of meat and poultry, avocados, legumes.

Banana is the leader in pyridoxine content among fruits and vegetables. But there is one caveat - this is true only for those countries where it is grown. In our area, the championship is occupied by potatoes. However, in order to save b6 in it to the maximum extent, it must be properly prepared.

High levels of the vitamin are found in the following foods (at a daily intake of 2 mg for adults):

However, remember that heat treatment of food products reduces the content of this miracle element in them. For example, bread baked from white flour contains only 20% of vitamins. This is in comparison with the amount that was in wheat grains. And when boiling potatoes (if you drain the water in which vegetables were cooked), 93% of pyridoxine is lost.

Conservation also does not allow saving b6 in full. During this processing, the product loses from 57% to 77% of the vitamin. Yes, and freezing has a detrimental effect on him.

Instructions for use

For kids:

For adults:

Vitamin B6 is water soluble, which means it will be excreted from the body in the urine. For this reason, as a rule, there is no particular concern in connection with an overdose. But you should not abuse this element either, because it can cause an undesirable reaction of the body.

I emphasize once again that pyridoxine is water-soluble. This means that the body is not able to store this element for future needs. Therefore, you should regularly eat foods rich in B6.

Indications for the use of an additional vitamin complex:

• anemia;
• seasickness;
• toxicosis in pregnant women;
• hepatitis;
• leukopenia;
• autism;
• dermatitis, psoriasis and other skin diseases;
• diseases of the nervous system, etc.

If you are going to buy pyridoxine supplements from a pharmacy, be sure to get a high quality product. Pyridoxine hydrochloride is sold in tablets and ampoules.

Just don't self-medicate. Everything can end up with the fact that later you will “solve the puzzle” - what is this happening to the body. And then you will definitely have to go to the doctor so that he can heal you. Agree, the price of such an experiment is too high.

Benefits of Vitamin B6

1. Supports vascular health. Pyridoxine is needed to regulate blood levels of a substance called homocysteine. It is a type of amino acid obtained from protein foods. Its high rates are associated with the development of diseases of the heart and blood vessels. Without enough vitamin B6, homocysteine ​​builds up in the body and damages blood vessels. As a result, it can provoke a heart attack or stroke. Recent studies have shown that this vitamin works best with folic acid. When patients take this "duet", the total concentration of homocysteine ​​is significantly reduced ( 2 ).
   
   
2. Supports brain function. Vitamin helps its proper development and functioning. Studies have shown that b6 deficiency can affect memory function and contribute to the development of cognitive impairment (Alzheimer's disease and age-related dementia) ( 3 ). Also, this element plays an important role in the creation of serotonin and norepinephrine. Known as “happiness hormones,” these two hormones help control mood, energy, and focus. Researchers believe that certain behavioral disorders in children are caused by low levels of serotonin. Thus, taking vitamin B6 may have a beneficial effect on children ( 4 ).
3. Improves mood. Some prescription antidepressants contain vitamin B6. It has a significant effect on the production of serotonin and the neurotransmitters GABA in the brain. These are very important hormones that control mood. They are also needed to prevent depression, pain, fatigue and anxiety ( 5 ).
4. Helps treat anemia. This element is necessary for the creation of hemoglobin in the blood. It also transports red blood cells throughout the body. This helps bring oxygen to the cells and mobilize iron. Anemia is accompanied by such symptoms: fatigue, dizziness, pain. Research shows that consuming pyridoxine may help reduce the symptoms of anemia. And in some cases, this element helps prevent this disease.
5. Protects eye health. In many cases, poor nutrition and nutritional deficiencies are the underlying causes of many eye diseases. Research has shown that taking vitamin B6 + folic acid can help prevent disease. It even helps prevent complete loss of vision.
6. Reduces symptoms of rheumatoid arthritis. Low levels of vitamin B6 are associated with increased symptoms of rheumatoid arthritis. Several studies have found that people with this condition need more B6 intake. This is because they experience constant muscle and joint pain due to chronic inflammation.
   
   
7. Helps in the treatment of hypertension. Some research suggests that taking this vitamin may help lower blood pressure in people with hypertension. This element increases blood flow and reduces its accumulation in the arteries.
8. Helps relieve symptoms of PMS. Consuming plenty of pyridoxine may help prevent painful period symptoms ( 6 ). Studies have shown that this element helps in the fight against chest pain, nausea, cramps, and fatigue. And even with acne, which is a harbinger of the menstrual cycle. For women who experience frequent PMS symptoms, it is recommended to take B vitamins regularly. It is especially important to do this 10 days before menstruation.
9. Helps reduce nausea during pregnancy. Studies have shown that taking this element is effective in reducing the severity of nausea and morning sickness. Patients were monitored for 6 weeks (24 hours a day). They noted how they felt before treatment and with vitamin B6. After this time, there was a significant reduction in nausea compared with the placebo group ( 7 ).
10. Helps in the treatment of asthma. Some studies have shown that this vitamin reduces the subsequent occurrence of asthma attacks and reduces their frequency.
11. Helps regulate sleep cycles. This wonder drug helps the body produce melatonin, which is an important hormone that helps us fall asleep. Melatonin is responsible for giving us the opportunity to regulate our internal clock. So we know when it's time to wake up and when it's time to sleep.
12. Prevents the formation of kidney stones. Some experience shows that taking pyridoxine along with other minerals (including magnesium) is very beneficial. It helps prevent or even cure kidney stones.

Interaction of vitamin B6 with other drugs

This item may interact with medications. Therefore, if you are already taking any medications, be sure to consult your doctor.

The list of medications that interact with vitamin B6 is huge. This list can include:

• any drugs used in chemotherapy;
• cycloserine or isoniazid - used in the treatment of tuberculosis;
• hydralazine (Apresoline) - to treat high blood pressure;
• penicillamine - prescribed in the fight against rheumatoid arthritis;
• theophylline - used to treat asthma;
• antibiotics, including tetracyclines;
• antidepressants including elavil, desipramine, imipramine and norparmin;
• some antidepressants called monoamine oxidase inhibitors (they lower blood levels of B6).

I am sure that today you have replenished your knowledge of the vital elements. And they made real discoveries for themselves in relation to pyridoxine. Do not lose your qualifications - subscribe to updates. And drop the link to the article to your friends - this info will come in handy for them. And I say goodbye to you - until we meet again.

Vitamin B6 is a water-soluble element that is important for the health of adults and children. With the help of this component, the process of assimilation of unsaturated fatty acids, which are necessary for cellular synthesis, takes place.

Pyridoxine, due to its active interaction with calcium, supports the work of the heart. He is also involved in hematopoiesis.

Deficiency of this microelement in children causes disturbances in the functioning of the nervous system. The baby begins to act up, sleeps restlessly, sometimes muscle spasms may even appear. However, only the attending physician will prescribe the drug for a child under the age of 1 year.

The need for admission

All B vitamins are important for the normalization of many biochemical processes in the human body. In addition, they help improve visual acuity, and also have a beneficial effect on the condition of the skin.

Pyridoxine helps the liver function properly. And also it affects the following body processes:

• normalizes the functioning of the nervous system;
• controls the level of glucose in the blood;
• helps to carry out energy metabolism in the body;
• increases the production of serotonin, a hormone that is responsible for the state of happiness;
• improves the protective functions of the body;
• has a beneficial effect on appearance.

In an adult, pyridoxine deficiency is extremely rare. This is because this component enters the body daily with food consumed. Since the children's body is subject to the negative influence of the environment, some babies may experience a lack of one or another element.

With a lack of this vitamin, the following symptoms appear:

• mood variability;
• apathy and lethargy;
• lack of healthy sleep;
• the skin acquires an uncharacteristic yellow color;
• malfunctions of the cardiovascular system.

The dosage of the drug for infants under the age of six months should not exceed 500 mcg per day. If necessary, in the process of growing up the child, the maximum dose increases. So, already at the age of 1 year, the use of 1 mg of the substance per day is allowed.

IMPORTANT! Deficiency of this component is often observed in young children with artificial feeding with a mixture.

Indications for use for children

The main reason when Vitamin B6 is used, and why children need it, is beriberi in various forms. The disease provokes the following manifestations in the baby:

• numerous dermatitis on the face and neck;
• cracked lips;
• sores in the mouth;
• inflammation of the eyes;
• poor appetite;
• nausea and vomiting.

However, if any symptom appears, pyridoxine should not be started immediately. Because such signs are characteristic of many other abnormalities that occur in children. Only a doctor can prescribe the drug for admission, as well as calculate the dosage, especially when it comes to the health of the baby.

Also vitaminB6 apply for the following deviations:

• Anemia. The component promotes the production of hemoglobin and is involved in the process of hematopoiesis.
• hepatitis in various forms.
• neurological abnormalities.
• Diabetes. The trace element contributes to the normalization of glucose levels.
• Autism in a child.

In this case, it is important to remember that Pyridoxine is only an auxiliary substance that will help speed up the treatment process for the above pathologies. However, you should not hope that only with the help of vitamin complexes you can get rid of the symptoms of anemia, diabetes and other diseases.

Instructions for use

Instructions for use of the drug for the treatment of a child practically do not differ from that recommended for adults. The main difference in the reception is the correct dosage of the component.

For preventive purposes, children over 6 years of age are recommended to take no more than 2 mg of the drug per day. If the drug is used in the treatment of any disease, then a dosage of up to 20 mg per day is acceptable. However, this depends on the age of the child.

When muscle spasms occur in children, there is a need for injections of the drug. Pyridoxine is administered intramuscularly or intravenously up to 100 mg per day.

Until now, there is no dose of the drug, which could be considered the limit. The required amount of the substance is calculated based on the characteristics of the patient's body and the severity of the disease.

Overdose and side effects

The drug does not cause a toxic effect, so an overdose is extremely rare even after taking a substance above the norm specified in the instructions. However, sometimes unwanted symptoms occur when a large dose of a substance is consumed:

• rash on the skin;
• stabbing sensations at the fingertips;
• loss of consciousness.

If these symptoms occur, you should stop taking this drug. Already 1-2 days after the cessation of therapy, the condition will return to normal. If after a while the signs of an overdose have not ceased to bother, then the child needs urgent medical care.

Interaction with other drugs

Substances that reduce the level of activity of the vitamin:

• when using pyridoxine with certain types of antibiotics, efficiency decreases;
• when the component is combined with vitamin C and nicotinic acid, its effect is also reduced;
• some types of antidepressants can reduce the concentration of vitamin B6 in the blood.

But certain types of beneficial components contribute to the enhanced effects of pyridoxine. So, when taking the drug in combination with glutamic acid, vitamin B6 enhances its effect.

Vitamin B6 is often prescribed to be taken in combination with magnesium. Then it performs only the role of a catalyst for better absorption of magnesium.

Where is contained

It is found in foods of plant origin: buckwheat, beans, lettuce, green onions, hercules. And also the component is contained in a lower concentration: dairy products, chicken meat, fish.

Vitamin loses most of its beneficial properties after heat treatment. Especially if the dish was cooked under a closed lid. Also, such products become less useful after prolonged freezing.

If the child was prescribed to take Pyridoxine, then the daily rate should be divided into 2 or 3 doses. Also, you should not drink the drug with milk and use it in combination with calcium.

A proper and balanced diet saturates our body with all the necessary nutrients. To date, scientists have compiled a list of 13 essential and indispensable vitamins for each of us. One of them is the “vitamin of life” B6, since without it it is impossible to imagine the process of the very origin of life, its development and full flow.

Description and general characteristics

Vitamin B6 is the common name for three substances: pyridoxine, pyridoxal, and pyridoxamine. An integral part of health for any person, because B6 performs a number of important functions in our body. First of all, it stimulates the metabolism in the human body. Regulates the digestibility of proteins, participates in the processing of amino acids. It plays an important role in the production of blood cells and hemoglobin, and also helps to supply cells with glucose.

It is not able to accumulate in the body (it is excreted within 8 hours), so its supply must be constantly replenished. Soluble in water and alcohol, but insoluble in ether and fats. It is little affected by the destructive action of oxygen and temperatures, but is easily and quickly destroyed by sunlight.

Did you know? If you store vegetables in the refrigerator for even a few days, they lose up to 30% of all nutrients. And you can save the most benefits by steaming food.

Main functions and benefits for the body

B6 is necessary for absolutely all people, regardless of gender, age and occupation. It performs a huge number of functions, without which our body will not be able to fully work and develop:

• regulates the work of the immune and nervous systems (strengthens the protective functions of the body, saves us from depression, makes us more resistant to stress);
• helps to prevent anemia;
• improves digestive processes. But for different people, B6 also helps with narrower problems that are inherent in a particular gender, age or physical condition.

One of the important components of health for men is the improvement of potency and male power in general. Various B vitamins, including B6, help with this. It takes an important part in the production of serotonin (the hormone of happiness) and thus ensures the full functioning of the nervous system. Muscles become stronger and fatigue more slowly.
It is also important to remember that the level of physical activity in males tends to be higher and harder than in women. Therefore, B6 is eliminated from the body faster and requires frequent replenishment, especially during intense sports or regular physical work.

Important! Only some vitamins tend to accumulate (A, D, E and K) and stay in the body. So you can not eat vitamins in advance, their content must always be maintained at the proper level.

B6 directly affects female beauty, because the health of the skin and hair depends on it. Also, strengthening the nervous system has a beneficial effect on the appearance of every woman. An increased amount of stress accelerates the process of removing B6 from the body, which means that it needs to be replenished more often, especially for women prone to nervous overload. B6 also helps to get through the menopause more easily and relieve unpleasant symptoms.
Very important B6 is for pregnant women. One of the important minerals for every pregnant woman is magnesium, which is better absorbed in combination with B6. It is the preparations and products with these elements that provide the expectant mother with good sleep, mood and emotional stability in general. Also, an increased need for all trace elements and vitamins (including B6) remains after childbirth in nursing mothers. The body has already spent and continues to spend all the resources in greater quantities than usual. Therefore, it is necessary to replenish stocks, otherwise it may adversely affect both the health of the mother and the health of the child himself.

For kids

B6 is very important for the formation of the body, starting from prenatal development. Further, its importance does not decrease. Since B6 helps the body strengthen the nervous system, it is very important for every child. Children are very often subject to stress due to constant adaptation to new living conditions.
An unstable emotional state later results in tearfulness and constant tantrums in a child. Also, the presence of B6 in the required amount in a child provides more effective learning, intelligence and normalizes sleep, making the child more resistant to environmental influences.

Vitamin Sources

To get B6 in the required amount, you just need to adjust your nutrition system. A conscious and rational approach to choosing what, when and how much to eat directly affects our well-being and health. By adjusting your diet, you can get rid of many unpleasant symptoms and prevent possible health problems in the future.

Therefore, a balanced diet and the constant presence of products from the list below in your diet guarantees the supply of vitamin B6 in full, without the use of artificial drugs.

vegetable

Vegetable protein is necessary for a complete and varied human diet, and can be found in such products: cereals (preferably unpeeled), cereals, legumes, soybeans, citrus fruits, cauliflower and white cabbage, tomatoes,.

Animals

Animal protein is easier and faster absorbed by the human body, so its presence in the diet is necessary. B6 is found in foods such as organ meats, seafood, bovine liver and cod, and,. Also in the body of a healthy person, B6 is synthesized by the intestinal microflora. But in the conditions of modern life, this function does not work as fully as it should.

Important! During cooking, about 40% of vitamin B6 is lost. Therefore, it is worth minimizing the impact of high and low temperatures during cooking, thereby preserving useful vitamins.

Daily requirement and norm

The recommended daily intake of B6 depends on gender, age and individual characteristics. Below are the specific intakes of B6 (mg per day) for different categories of people.

babies

The daily norm of B6 for infants is:

• 0-3 months - 0.4 mg;
• 4-6 months - 0.5 mg;
• 7-12 months - 0.6 mg.

Children

The daily norm of B6 for children is:

• 1-3 years - 0.9 mg;
• 3-7 years - 1.2 mg;
• 7-11 years - 1.5 mg;
• 11-14 years old - 1.6 mg (women) and 1.7 mg (men);
• 14-18 years old - 1.6 mg (female) and 2.0 mg (male).

adults

The daily allowance for B6 for adults is 2.0 mg per day.

Pregnant and lactating

The daily norm of B6 for pregnant and lactating women is:

• 2nd half of pregnancy - 1.8-2.4 mg.
• lactating - 2.0-2.6 mg.

Elderly

The daily allowance for B6 for the elderly is 2.0 mg per day.

Did you know? Some people who take the recommended dose of B6 experience very vivid and emotional dreams at night.

Deficiency and excess

An unbalanced diet can lead to failure in various body systems. Too much or too little B6 can present with a variety of symptoms and make life difficult for you.

Hypovitaminosis

With a lack of B6, the following symptoms can be observed:

• increased nervousness, anxiety, poor sleep, reaction inhibition,;
• malfunctions of the immune system;
• loss of appetite, nausea or vomiting;
• protracted;
• seborrhea, dermatitis, stomatitis, cheilosis;
• conjunctivitis, polyneuritis of the extremities.

Hypervitaminosis

An excess of B6 can have the following symptoms:

• intoxication;
• increased acidity of gastric juice;
• allergic reactions on the skin (urticaria, itching);
• tingling sensation, numbness, loss of sensation in the arms and legs.

Important! It is possible to diagnose a lack or excess of vitamin B6 with the help of a general blood test.

Interaction with other substances

Corticosteroid hormones easily remove vitamin B6 from the body. Assimilation of vitamin B6 worsens with regular use of alcohol-containing preparations. Complexing compounds bind and block B6. Severe deficiency of vitamin B6 occurs when taking estrogen-containing, anticonvulsant and anti-tuberculosis drugs. Vitamin B6 may reduce the effectiveness of medications in the treatment of Parkinson's disease.

Dosage forms of pyridoxine

Vitamin B6 comes in 2 forms:

• in ampoules - "Pyridoxine", "Pyridoxine Bufus", "Pyridoxine-Vial";
• in tablets - "Pyridoxine hydrochloride", "Pyridoxine".

In addition to monocomponent preparations, B6 is also found in various vitamin complexes. All of them are divided into preventive and therapeutic. Preventive ("Supradin", "Centrum", "Vitrum")- is a set of most vitamins and minerals to be taken by people without any special diseases or very healthy in order to strengthen the general condition of the body. Therapeutic preparations contain only 2-5 vitamins, but in large dosages for the treatment of various diseases.

Important! Before you start taking a vitamin complex, consult your doctor. Self-medication can be dangerous for your health!

Possible harm and contraindications

A serious excess of B6 with dangerous consequences for the body is possible only when taking a dose of more than 100 mg per day for several years, which is impossible under natural conditions without medical intervention. Since this vitamin does not accumulate in the body and is excreted very quickly, overdose is not accompanied by severe side effects. There may be slight itching on the skin and nausea. If these symptoms appear, stop taking the medication and consult a doctor.

With a proper and balanced diet, an excess (as well as a lack) of vitamin B6 is unlikely. The vitamin itself has no contraindications and adverse health effects, as it is found in a large number of natural products and is well absorbed. A healthy lifestyle, the absence of bad habits, normal sleep and physical activity - all this, in combination with proper nutrition, helps us to be as cheerful and cheerful as possible. Attention to your physical condition and properly selected medical support, if necessary, can not only strengthen your body, but also protect you from serious diseases in the future.

It's time to learn something interesting about Vitamin B6, or Pyridoxine. Why is Vitamin B6 so important for the body, which is facilitated by the intake of B vitamins. What foods contain vitamin B6 and how much does a person need. Where to buy vitamin B6 and how much does it cost. Methods and recommendations for use.

#vitamin b6 #vitamin b6 #vitamin B

Most recently, I published a review on the complex drug Magne B6, which includes pyridoxine or, more simply, vitamin B6. The comments asked "why B6 and not some other vitamin." Well, apparently it's time to talk about the beneficial properties of pyridoxine ...

First, some information from official sources:

Vitamin B6 is a water-soluble vitamin that enters the human body with various foods. Its active form, pyridoxal phosphate, is involved in more than 100 enzymatic metabolic reactions. It plays a crucial role in the formation and development of the nervous system (especially in children) and affects the functioning of the hematopoietic and immune systems.

Vitamin B6 is the common name for three substances that enter the human body with food: pyridoxine, pyridoxal and pyridoxamine. Each of them in the process of metabolism passes into an active form - pyridoxal phosphate, which takes part in the formation of red blood cells, activation of immune reactions, the processes of glucose uptake by nerve cells and the synthesis of neurotransmitters, in protein metabolism, and also in fat metabolism, providing lipotropic and hypocholesterolemic effect.

If we simplify the wording a little, we can draw several important conclusions:

• Vitamin B6 is a necessary component for influencing the cells of the nervous system (recall Magne B6)
• Vitamin B6 is involved in the breakdown of fats, therefore it is very useful for the liver and for the cardiovascular system (normalization of cholesterol, remember Omacor, which also includes pyridoxine
• Vitamin B6 is able to suppress glycation - and this is one of the mechanisms of aging. We will talk about this separately.

Who needs Vitamin B6

Rather, it is obligatory for everyone, but for which diseases it is very important to control the use of Vitamin B6, we will now find out:

• Atherosclerosis and cardiovascular disease! Omega-3 therapy + Magnesium citrate + Potassium citrate + required Vitamin B6
• Established anemia. Almost all types.
• Hepatitis (liver disease)
• Diseases of the nervous system (even neuralgia and radiculitis!) Magnesium citrate + Vitamin B6
• Toxicosis during pregnancy.
• Leukopenia.
• Meniere's disease.
• Air and sea sickness.
• Various skin diseases (neurodermatitis, dermatitis, psoriasis, diathesis). This also includes acne.
• If, despite all efforts, you cannot lose weight (the cause may be a lack of vitamin B6)
• If you are taking any steroid medications

Vitamin B6 deficiency symptoms

I would not be so categorical and would not say that the following conditions arise due to a lack of vitamin B6 and only, but, nevertheless, they can also occur against the background of a clearly underestimated level of B6 in the body. Therefore, with similar symptoms, the use of vitamin B6 will not be superfluous, given that it is not so easy to get the daily intake of the vitamin from ordinary foods.

• Drowsiness, irritability, lethargy;
• loss of appetite, nausea;
• Dry skin above the eyebrows, around the eyes, on the neck;
• Cracks and sores in the corners of the mouth;
• Focal hair loss;
• Insomnia;
• Depression;
• Flatulence;
• The appearance of kidney stones;
• Conjunctivitis;
• Stomatitis.

Products containing Vitamin B6

Rather, several products that have a high percentage of Vitamin B6 in their composition.

plant sources- unpeeled grains of all types of cereals and cereals, potatoes, legumes, bananas, nuts, cabbage of all kinds, soybeans. Animal Sources- liver, meat, dairy products, kidneys, eggs (especially in raw yolk) and fish.

It should be noted here that, unfortunately, the figures reflecting the percentage of vitamin content in products are just numbers, often having nothing to do with the real picture, so we don’t even give them. In fact, today's supermarket products contain very few vitamins and minerals, thanks to "advanced methods" of growing, processing and storing food. Alas.

It is important to remember that vitamin B6, and all vitamins, are partially destroyed during heat treatment. And the B vitamins are even more susceptible to destruction. For example, white bread contains vitamin B6 5 times less than it is found in wheat grains.

Therefore, if you need Vitamin B6, then the fastest and reliable the way to "bring in order" its level is a course of preparations with a high content of Vitamin B6, and even better if the preparation contains only B6. Usually, such preparations contain a daily dose of a vitamin or it is easy to calculate, and such preparations are conveniently combined with other monopreparations, for example, with magnesium citrate.

Here is what the iHerb portal offers us (let me remind you that this is a reliable and proven supplier of the highest quality drugs at prices lower than in ordinary pharmacies)

• Solgar, Vitamin B6 - 100 x 25mg Tablets, 1 tablet per day for most. Course for 3 months. Price - 350 rubles
• Solgar, Vitamin B6 (50 mg) - 100 50 mg Tablets. Convenient for those who need more vitamin, older men, smokers, etc. Price - 410 rubles, the course is designed for 3 months.