Thioctacid bv loading dose. Thioctacid bv - instructions for use

metabolic drug. Thioctic (α-lipoic) acid is found in the human body, where it functions as a coenzyme in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. Thioctic acid is an endogenous antioxidant; according to the biochemical mechanism of action, it is close to B vitamins.

The drug has a hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect; improves neuronal trophism. The result of the synergistic action of thioctic acid and insulin is an increase in glucose utilization.

Pharmacokinetics

Suction

When taking the drug Thioctacid ® BV (rapid release) orally, thioctic acid is rapidly and completely absorbed from the gastrointestinal tract. Simultaneous ingestion of food may reduce the absorption of the drug. Cmax in blood plasma is reached 30 minutes after ingestion and is 4 μg / ml. The absolute bioavailability of thioctic acid is 20%.

Metabolism

It undergoes the effect of "first pass" through the liver. The main metabolic pathways are oxidation and conjugation.

breeding

T 1/2 is 25 min. Thioctic acid and its metabolites are excreted in the urine (80-90%).

Release form

Tablets, film-coated, yellow-green, oblong, biconvex.

Excipients: low-substituted hyprolose - 157 mg, hyprolose - 20 mg, magnesium stearate - 24 mg.

The composition of the film shell: hypromellose - 15.8 mg, macrogol 6000 - 4.7 mg, titanium dioxide - 4 mg, talc - 2.02 mg, aluminum varnish based on quinoline yellow dye - 1.32 mg, aluminum varnish based on indigo carmine - 0.16 mg.

30 pcs. - dark glass bottles (1) - packs of cardboard.
60 pcs. - dark glass bottles (1) - packs of cardboard.
100 pieces. - dark glass bottles (1) - packs of cardboard.

Dosage

Inside appoint 600 mg (1 tab.) 1 time / day. Tablets are taken on an empty stomach, 30 minutes before breakfast, without chewing and drinking water.

In severe cases, treatment begins with the appointment of a solution for the on / in the introduction of Thioctacid ® 600 T for 2-4 weeks, then the patient is transferred to treatment with Thioctacid ® BV.

Overdose

Symptoms: when taking thioctic (α-lipoic) acid at a dose of 10 g to 40 g, there may be serious signs of intoxication (generalized convulsive seizures; severe violations of the acid-base balance (leading to lactic acidosis), hypoglycemic coma, severe blood clotting disorders, sometimes leading to death. outcome).

Treatment: if a significant overdose of the drug is suspected (for example, taking more than 10 tablets for adults or more than 50 mg / kg of body weight for a child), immediate hospitalization is necessary with symptomatic therapy, if necessary, anticonvulsant therapy, measures to maintain the functions of vital organs.

Interaction

With the simultaneous appointment of thioctic acid and cisplatin, there is a decrease in the effectiveness of cisplatin.

Thioctic (α-lipoic) acid binds metals, so it should not be administered simultaneously with drugs containing metals (for example, iron, magnesium, calcium preparations). If Thioctacid ® BV is taken 30 minutes before breakfast, then preparations containing iron or magnesium can be taken in the afternoon or evening.

With the simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may increase, so regular monitoring of blood glucose levels is recommended, especially at the beginning of thioctic acid therapy. In some cases, it is permissible to reduce the dose of hypoglycemic drugs in order to avoid the development of symptoms of hypoglycemia.

Ethanol and its metabolites weaken the effect of thioctic acid.

Side effects

The incidence of side effects is defined as follows: very often (> 1/10); often (>1/100,<1/10); нечасто (>1/1000, < 1/100); редко (>1/10 000, <1/1000); очень редко (<1/10 000).

From the digestive system: often - nausea; very rarely - vomiting, pain in the stomach and intestines, diarrhea, changes in taste sensations.

Allergic reactions: very rarely - skin rash, urticaria, itching, anaphylactic shock.

From the nervous system: often - dizziness.

On the part of the body as a whole: very rarely - due to improved glucose utilization, blood glucose levels may decrease and symptoms of hypoglycemia may appear (confusion, increased sweating, headache, visual disturbances).

Indications

diabetic polyneuropathy;
alcoholic polyneuropathy.

Contraindications

pregnancy (there is no sufficient experience in the use of the drug);
the period of breastfeeding (there is no sufficient experience in the use of the drug);
children and adolescence (there are no clinical data on the use of the drug in children and adolescents);
hypersensitivity to thioctic (α-lipoic) acid and other components of the drug.

Application features

Use during pregnancy and lactation

The appointment of the drug during pregnancy and lactation is contraindicated, because. there is no sufficient experience with the use of the drug during these periods.

Use in children

Contraindication: children and adolescents (there are no clinical data on the use of the drug in children and adolescents).

special instructions

Alcohol consumption is a risk factor for the development of polyneuropathy and may reduce the effectiveness of the drug Thioctacid ® BV, so patients should refrain from taking alcoholic beverages both during treatment with the drug and during periods outside of treatment.

Treatment of diabetic polyneuropathy should be carried out against the background of maintaining the optimal concentration of glucose in the blood.

Due to the fact that thioctic acid binds metals, and Thioctacid ® BV tablets are taken 30 minutes before breakfast, preparations containing metals should be taken at lunch or in the evening. For the same reason, during the period of treatment with Thioctacid BV, it is recommended to consume dairy products only in the afternoon.

Thioctacid 600 T is a metabolic drug that regulates lipid and carbohydrate metabolism and has an antioxidant effect. Indications for treatment with Thioctacid are clinical manifestations in patients with diabetes mellitus, peripheral polyneuropathy. Thioctic acid protects the cell from toxic "creeps" of free radicals formed during metabolic processes.

Release the drug in the form of a solution for injection of a transparent yellowish color. You can also buy Thioctacid in the form of yellowish-greenish film-coated tablets. Thioctic acid, which is part of it, is produced by the body. But with alcohol abuse, diabetes mellitus and a number of other diseases, the amount synthesized by the body is not enough for the normal functioning of nerve cells.

Active ingredient: thioctic acid (thioctic (-lipoic) acid). Thioic acid is a powerful endogenous antioxidant, its mechanism of action is very close to that of vitamin B.

1 ampoule contains the active substance - trometamol thioctate - 952.3 mg, which is equivalent to the content of 600 mg of thioctic (-lipoic) acid.
1 coated tablet contains 600 mg of thioctic (-lipoic) acid.

People suffering from alcoholism, diabetes mellitus and a number of other serious diseases caused by metabolic disorders often experience a deficiency of adenosine triphosphate (ATP) acid. An additional portion of the active metabolite restores the structure of nerve fibers and increases their functionality.

Short-acting tablets are simply called Thioctacid, and prolonged - Thioctacid BV. The concentrate for the preparation of a solution for intravenous infusion is correctly called Thioctacid 600.

The main component of the drug is an endogenous antioxidant, the presence of which in the body provides:

normalization of neuronal trophism;
enhanced removal of glucose;
protection of cells from the effects of toxins and free radicals;
reduction of symptoms of pathology.

Thus, Thioctacid 600, according to the official instructions for use, has a hypolipidemic, hepatoprotective, hypoglycemic and hypocholesterolemic effect. The drug is successfully used for the treatment and prevention of neuropathy and sensitivity disorders caused by this pathology in alcoholism and diabetes mellitus. Reviews of doctors and patients about Thioctacid 600 confirm the high efficiency of the drug.

Indications for use Thioctacid 600

Indications for the use of Thioctacid 600 are:

diabetic and alcoholic polyneuropathy,
hyperlipidemia,
fatty degeneration of the liver,
cirrhosis of the liver and hepatitis,
intoxication (including salts of heavy metals, pale grebe),
treatment and prevention of coronary atherosclerosis.

Instructions for use Thioctacid 600, dosage

Standard dosages

Thioctacid 600 injections are administered intravenously (stream, drip). Thioctacid 600 tablets - a dosage of 600 mg / day for 1 dose (in the morning on an empty stomach 30-40 minutes before breakfast), the appointment of 200 mg 3 times a day is less effective.

Special

In severe forms of polyneuropathies - in / in slowly (50 mg / min), 600 mg or / in drip, 0.9% NaCl solution 1 time per day (in severe cases, up to 1200 mg is administered) for 2-4 weeks. In the future, they switch to oral therapy (adults - 600-1200 mg / day, adolescents - 200-600 mg / day) for 3 months. In / in the introduction is possible with the help of a perfusor (the duration of the introduction is at least 12 minutes).

The method of thioctacid treatment of patients suffering from diabetic polyneuropathies is well developed and has a solid scientific and practical basis. Therapy begins with the introduction of thioctacid intravenously at a dose of 600 mg for two weeks.

With simultaneous treatment with potent drugs and Thioctacid, the recommendations of the attending physician should be strictly observed.

Application features

Many patients complain about the long time it takes to administer Thioctacid 600 T as a solution for intravenous infusion. Despite this, doctors recommend this particular form of the drug at the beginning of the treatment of the disease. It is completely absorbed and allows you to titrate the effective dosage as accurately as possible.

When using the drug, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

If there is a need to simultaneously take these drugs, then you need to maintain an interval between taking them at five to six hours.

The drug in ampoules is not exposed to light until direct use. The prepared solution is used within six hours and protected from light.

Drinking alcohol may reduce the effectiveness of the drug. Therefore, it is recommended to refrain from taking any liquids containing alcohol during treatment with the drug.

Combine with caution with metal-containing agents, cisplatin, insulin, diabetes medications.

At the initial stages of treatment, it is possible to increase the discomfort in neuropathy, which is associated with the process of restoring the structure of the nerve fiber.

Side effects and contraindications Thioctacid 600

With the rapid intravenous administration of Thioctacid 600 T, intracranial pressure can sometimes increase and breath holding can be observed. As a rule, these disorders go away on their own.

During the use of Thioctacid, in some cases, the level of glucose in the blood may decrease (due to improved utilization). In this case, hypoglycemia may occur, the main symptoms of which are: dizziness, headache, increased sweating (hyperhidrosis) and visual disturbances.

Dosage form: film-coated tablets Compound:

Active substance: thioctic acid (alpha-lipoic acid) - 600 mg.

Excipients: low-substituted hyprolose 157.00 mg, hyprolose 20.00 mg, magnesium stearate 24.00 mg.

Film coat: hypromellose 15.80 mg, macrogol 6000 4.70 mg, titanium dioxide 4.00 mg, talc 2.02 mg, aluminum varnish based on quinoline yellow dye 1.32 mg, aluminum varnish based on indigo carmine 0.16 mg .

Description:

: yellow-green biconvex oblong film-coated tablets,

Pharmacotherapeutic group:metabolic agent ATX:

A.16.A.X.01 Thioctic acid

Pharmacodynamics:

Thioctic (a-lipoic) acid is found in the human body, where it acts as a coenzyme in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. is an endogenous antioxidant, according to the biochemical mechanism of action, it is close to B vitamins.

Thioctic acid helps protect cells from the toxic effects of free radicals that occur in metabolic processes; it also neutralizes exogenous toxic compounds that have entered the body. increases the concentration of the endogenous antioxidant glutathione, which leads todecrease in severitysymptoms of polyneuropathy. The drug has a hepatoprotective effect,hypolipidemic, hypocholesterolemic, hypoglycemic action;

improves neuronal trophism. The result of the synergistic action of thioctic acid and insulin is an increase in glucose utilization.

Thioctacid® BV (rapidrelease) is an optimized oral dosage form that avoids high concentration variabilitythioctic acid in blood plasma.

Pharmacokinetics:

When taking the drug orally, it is quickly and completely absorbed from the gastrointestinal tract. Taking the drug Thioctacid® BV simultaneously with food intake may reduce the absorption of thioctic acid. Taking the drug according to the recommendations 30 minutes before meals avoids unwanted interaction with food, since the absorption of thioctic acid at the time of eating has already been completed. Maximum concentrationthioctic acid in blood plasma is reached 30 minutes after taking the drug and is 4 μg / ml. has the effect of "first pass" through the liver. Absolutethe bioavailability of thioctic acid is 20%. The main metabolic pathways are oxidation and conjugation. and hermetabolites are excreted by the kidneys (80-90%). The half-life is 25 minutes.

Indications:

Diabetic and alcoholic polyneuropathy.

Contraindications:

Hypersensitivity to thioctic acid or other components of the drug.

Pregnancy, breastfeeding (there is no sufficient experience with the drug).

There are no clinical data on the use of Thioctacid 600 BV in children and adolescents; therefore, the drug should not be prescribed to children and adolescents.

Dosage and administration:

In severe cases, treatment begins with the appointment of Thioctacid 600 T solution for intravenous administration for 2 to 4 weeks, then the patient is transferred to treatment with Thioctacid BV.

Side effects:

The incidence of side effects is defined as follows:

Very common: > 1/10;

Often:<1/10 > 1/100;

Infrequently:<1/100 > 1/1000;

Rarely:<1/1000> 1/10000;

Very rarely:<1/10000.

From the gastrointestinal tract:

Often - nausea; very rarely - vomiting, pain in the stomach and intestines, diarrhea, changes in taste sensations.

Allergic reactions: Very rarely - skin rash, urticaria, itching, anaphylactic shock.

From the nervous system and sensory organs: Often - dizziness.

General:

Very rarely - due to improved glucose utilization, blood glucose levels may decrease and symptoms of hypoglycemia may appear (confusion, increased sweating, headache, visual disturbances).

Overdose:

Symptoms:

In the case of taking thioctic (a-lipoic) acid in doses of 10-40 g, serious signs of intoxication may occur (generalized convulsive seizures: severe acid-base balance disorders leading to lactic acidosis: hypoglycemic coma: severe blood clotting disorders, sometimes leading to a fatal outcome ).

If a significant overdose of the drug (doses equivalent to more than 10 tablets for an adult or more than 50 mg kg of body weight for a child) is suspected, immediate hospitalization is required.

Treatment: symptomatic, if necessary - anticonvulsant therapy, measures to maintain the functions of vital organs.

Interaction:

With the simultaneous appointment of thioctic acid and cisplatin, there is a decrease in the effectiveness of cisplatin. binds metals, so it should not be administered simultaneously with drugs containing metals (for example, iron, magnesium, calcium preparations). According to the recommended route of administration, Thioctacid® 600 BV tablets are taken 30 minutes before breakfast, while preparations containing metals should be taken in the afternoon or evening. For the same reason, during the period of treatment with Thioctacid 600 BV, it is recommended to consume dairy products only in the afternoon.

Ethanol and its metabolites weaken the effect of thioctic acid.

Special instructions:

Alcohol consumption is a risk factor for the development of polyneuropathy and may reduce the effectiveness of Thioctacid1 BV, so patients should refrain from taking alcoholic beverages both during treatment with the drug and during periods outside of treatment.

Treatment of diabetic polyneuropathy should be carried out against the background of maintaining the optimal concentration of glucose in the blood.

P N015545/01

Tradename: Thioctacid ® BV

INN or grouping name: Thioctic acid

Dosage form:

Film-coated tablets

Compound:

1 film-coated tablet contains:

Active substance: thioctic acid (a-lipoic acid) - 600 mg.

Excipients: low-substituted hyprolose, hyprolose, magnesium stearate. Film sheath: hypromellose, macrogol 6000, titanium dioxide, talc, quinoline yellow dye aluminum lacquer, indigo carmine aluminum lacquer.

Description: yellow-green biconvex oblong film-coated tablets .

Pharmacotherapeutic group:

metabolic agent.

ATX code: A05BA

Pharmacological properties

Pharmacodynamics

Thioctic (a-lipoic) acid is found in the human body, where it acts as a coenzyme in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. Thioctic acid is an endogenous antioxidant; according to the biochemical mechanism of action, it is close to B vitamins.

Thioctic acid helps protect cells from the toxic effects of free radicals that occur in metabolic processes; it also neutralizes exogenous toxic compounds that have entered the body. Thioctic acid increases the concentration of the endogenous antioxidant glutathione, which leads to a decrease in the severity of symptoms of polyneuropathy. The drug has a hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect; improves neuronal trophism. The result of the synergistic action of thioctic acid and insulin is an increase in glucose utilization.

Pharmacokinetics

When taken orally, it is rapidly and completely absorbed from the gastrointestinal tract. Taking the drug at the same time as eating may reduce the absorption of the drug. The maximum plasma concentration is reached 30 minutes after taking Thioctacid BV and is 4 μg / ml. The drug has the effect of "first pass" through the liver, the absolute bioavailability of thioctic acid is 20%. The half-life is 25 minutes. The main metabolic pathways are oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%).

Indications for use

Diabetic and alcoholic polyneuropathy.

Contraindications

Hypersensitivity to thioctic acid or other components of the drug.

Pregnancy, breastfeeding (there is no sufficient experience with the drug).

There are no clinical data on the use of Thioctacid ® 600 BV in children and adolescents; therefore, the drug should not be prescribed to children and adolescents.

Dosage and administration

In severe cases, treatment begins with the appointment of Thioctacid ® 600 T solution for intravenous administration for 2 to 4 weeks, then the patient is transferred to treatment with Thioctacid ® BV.

Side effect

The incidence of side effects is defined as follows:

Very common: > 1/10;

Often:<1/10 > 1/100;

Infrequently:<1/100 > 1/1000;

Rarely:<1/1000> 1/10000;

Very rarely:<1/10000.

From the gastrointestinal tract:

Often - nausea; very rarely - vomiting, pain in the stomach and intestines, diarrhea, changes in taste sensations.

Allergic reactions: Very rarely - skin rash, urticaria, itching, anaphylactic shock.

From the nervous system and sensory organs: Often - dizziness.

General:

Very rarely - due to improved glucose utilization, blood glucose levels may decrease and symptoms of hypoglycemia may appear (confusion, increased sweating, headache, visual disturbances).

Overdose

Symptoms:

In the case of taking thioctic (a-lipoic) acid in doses of 10-40 g, there may be serious signs of intoxication (generalized convulsive seizures; severe acid-base balance disorders leading to lactic acidosis; hypoglycemic coma; severe blood clotting disorders, sometimes leading to a fatal outcome ).

If a significant overdose of the drug is suspected (doses equivalent to more than 10 tablets for an adult or more than 50 mg / kg of body weight for a child), immediate hospitalization is necessary.

Treatment: symptomatic, if necessary - anticonvulsant therapy, measures to maintain the functions of vital organs.

Interaction with other drugs

With the simultaneous appointment of thioctic acid and cisplatin, there is a decrease in the effectiveness of cisplatin. Thioctic acid binds metals, so it should not be administered simultaneously with drugs containing metals (for example, iron, magnesium, calcium preparations). According to the recommended route of administration, Thioctacid ® 600 BV tablets are taken 30 minutes before breakfast, while preparations containing metals should be taken in the afternoon or evening. For the same reason, during the period of treatment with Thioctacid ® 600 BV, it is recommended to consume dairy products only in the afternoon.

Ethanol and its metabolites weaken the effect of thioctic acid.

special instructions

Alcohol use is a risk factor for polyneuropathy and may reduce the effectiveness of Thioctacid ® BV, therefore, patients should refrain from taking alcoholic beverages both during treatment with the drug and during periods outside of treatment.

Treatment of diabetic polyneuropathy should be carried out against the background of maintaining the optimal concentration of glucose in the blood.

Release form

Film-coated tablets, 600 mg.

30, 60 or 100 tablets in a brown glass bottle with a capacity of 50.0, 75.0 or 125.0 ml, respectively, with a plastic cap with first opening control.

1 bottle with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than 25 ° C, out of the reach of children.

List B.

Best before date

Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

On prescription.

Manufacturer

MEDA Pharma GmbH & Co. KG

Benzstraße 1, 61352 Bad Homburg, Germany.

Produced

MEDA Manufacturing GmbH,

Neurater Ring 1, 51063 Cologne, Germany.

Claims of consumers should be sent to the address of the representative office in the Russian Federation:

125167, Moscow, Naryshkinskaya alley, 5/2, office 216

Thioctacid BV: instructions for use and reviews

Thioctacid BV is a metabolic drug with an antioxidant effect.

Release form and composition

Thioctacid BV is available in the form of film-coated tablets: green-yellow in color, oblong biconvex shape (30, 60 or 100 pieces in dark-colored glass bottles, 1 bottle in a cardboard bundle).

1 tablet contains:

active ingredient: thioctic (alpha-lipoic) acid - 0.6 g;
auxiliary components: magnesium stearate, hyprolose, low-substituted hyprolose;
composition of the film shell: titanium dioxide, macrogol 6000, hypromellose, aluminum varnish based on indigo carmine and quinoline yellow dye, talc.

Pharmacological properties

Pharmacodynamics

BV thioctacid is a metabolic drug that improves neuronal trophism, has hepatoprotective, hypocholesterolemic, hypoglycemic, and hypolipidemic effects.

The active substance of the drug is thioctic acid, which is found in the human body and is an endogenous antioxidant. As a coenzyme, it is involved in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. The mechanism of action of thioctic acid is close to the biochemical effect of B vitamins. It helps protect cells from the toxic effects of free radicals that occur during metabolic processes, and neutralizes exogenous toxic compounds that have entered the body. By increasing the level of the endogenous antioxidant glutathione, it causes a decrease in the severity of symptoms of polyneuropathy.

The result of the synergistic action of thioctic acid and insulin is an increase in glucose utilization.

Pharmacokinetics

Absorption of thioctic acid from the gastrointestinal tract (GIT) when taken orally occurs quickly and completely. Taking the drug with food may reduce its absorption. Cmax (maximum concentration) in plasma after taking a single dose is reached after 30 minutes and is 0.004 mg / ml. The absolute bioavailability of Thioctacid BV is 20%.

Before entering the systemic circulation, thioctic acid undergoes a first-pass effect through the liver. The main routes of its metabolism are oxidation and conjugation.

T 1/2 (half-life) is 25 minutes.

The excretion of the active substance Thioctacid BV and its metabolites is carried out through the kidneys. 80-90% of the drug is excreted in the urine.

Indications for use

diabetic polyneuropathy;
alcoholic polyneuropathy.

Contraindications

period of pregnancy;
breast-feeding;
childhood and adolescence;
hypersensitivity to the components of the drug.

Instructions for use of Thioctacid BV: method and dosage

According to the instructions, Thioctacid BV 600 mg is taken orally on an empty stomach, 0.5 hours before breakfast, swallowed whole and washed down with a sufficient amount of water.

Given the clinical feasibility, for the treatment of severe forms of polyneuropathy, it is possible to initially prescribe a solution of thioctic acid for intravenous administration (Thioctacid 600 T) for a period of 14 to 28 days, followed by the transfer of the patient to a daily intake of the drug inside (Thioctacid BV).

Side effects

from the digestive system: often - nausea; very rarely - vomiting, pain in the stomach and intestines, diarrhea, impaired taste sensations;
from the nervous system: often - dizziness;
allergic reactions: very rarely - itching, skin rash, urticaria, anaphylactic shock;
on the part of the body as a whole: very rarely - a decrease in blood glucose levels, the appearance of symptoms of hypoglycemia in the form of headache, confusion, increased sweating, visual impairment.

Overdose

Symptoms: against the background of a single dose of 10–40 g of thioctic acid, severe intoxication may develop with such manifestations as generalized convulsive seizures, hypoglycemic coma, severe acid-base balance disorders, lactic acidosis, severe blood clotting disorders (including fatal).

Treatment: if an overdose of Thioctacid BV is suspected (a single dose for adults is more than 10 tablets, for a child - more than 50 mg per 1 kg of body weight), the patient needs immediate hospitalization with the appointment of symptomatic therapy. If necessary, apply anticonvulsant therapy, urgent measures aimed at maintaining the functions of vital organs.

special instructions

Since ethanol is a risk factor for the development of polyneuropathy and causes a decrease in the therapeutic efficacy of Thioctacid BV, alcohol consumption is strictly contraindicated for patients.

In the treatment of diabetic polyneuropathy, the patient should create conditions that ensure the maintenance of an optimal level of glucose in the blood.

Use during pregnancy and lactation

Due to the lack of sufficient experience of use, the appointment of Thioctacid BV during gestation and breastfeeding is contraindicated.

Application in childhood

Since there are no clinical data on the use of Thioctacid BV in children and adolescents, it is contraindicated to use thioctic acid for their treatment.