Daily aspirin: benefits and risks. The drug "Aspirin" from what? How to use aspirin tablets in the fight against acne

Aspirin is an antipyretic, analgesic and anti-inflammatory agent. Even a person who is very far from medicine knows that it is not only fast, but also has a pronounced effect. Why is this happening? The fact is that acetylsalicylic acid has a depressing effect on the areas of the brain that are “responsible” for thermoregulation and pain sensitivity.

In addition, acetylsalicylic acid inhibits the activity of certain enzymes - cyclooxygenases, which are involved in the synthesis of prostaglandins (inflammatory mediators). As a result, inflammatory processes begin to proceed less actively, and eventually fade completely.

This is very important in cases where the inflammatory process in the body can lead to serious consequences, for example, with rheumatism.

Therefore, aspirin is very useful in the treatment of various inflammatory diseases, as well as diseases that cause high fever and pain syndrome of low or moderate intensity. In addition, it is cheap and available to almost any buyer. All this combined has made aspirin an exceptionally popular drug.

Finally, acetylsalicylic acid, reducing the likelihood of "gluing". Therefore, aspirin plays an important role in the prevention of heart attacks and strokes.

The same people who have suffered heart attacks and strokes are prescribed acetylsalicylic acid without fail to prevent the recurrence of these diseases (of course, in the absence of contraindications).

What are the contraindications for aspirin

As already mentioned, acetylsalicylic acid inhibits the activity of cyclooxygenase enzymes. However, one of these enzymes contributes to normal functioning. Accordingly, its blocking can lead to the development of an ulcer. Therefore, aspirin is not prescribed to patients with stomach diseases.

Acetylsalicylic acid is strictly contraindicated in patients with reduced blood clotting. It should also be used with great care

Aspirin has been used medicinally for over a century as an antipyretic and pain reliever. How often do we automatically take an Aspirin tablet with fever and pain. This inexpensive and very effective drug is sure to be found in everyone's family in a home medicine cabinet.

Application of Aspirin

It has been established that Aspirin helps to increase the level of interferon in the human body, and, therefore, can participate in strengthening the body's immune system.

Aspirin is also widely used as a means of preventing cardiovascular diseases. With the daily use of Aspirin in small doses, the risk of heart attacks and thrombosis is significantly reduced, since it is known that Aspirin reduces platelet aggregation and suppresses their function.

Aspirin (Acetylsalicylic acid) is also used in the complex treatment of certain diseases, for example, in gynecology; in the treatment of women with recurrent miscarriage, Aspirin is used in combination with heparin.

There are some studies that suggest that aspirin reduces the chance of developing cataracts. The occurrence of cataracts is often associated with low blood glucose levels, and the action of Aspirin is such that it significantly reduces the consumption of glucose.

Rules for the use of Aspirin

If we are talking about the prevention of cardiovascular diseases, then take half a tablet every other day, after consulting with your doctor.

Contraindications and side effects

MirSovetov in no case advises the use of Aspirin, like any other drug, without consulting a doctor. For all its effectiveness and harmlessness, the drug can greatly harm and endanger health.

Aspirin should not be used as a local anesthetic for toothache, as acetylsalicylic acid can cause mucosal burns.

Mandatory consultation with a doctor about taking Aspirin for people with hypertension and other cardiovascular diseases, diseases of the gastrointestinal tract (gastric and duodenal ulcers, gastritis, etc.).

Unfortunately, cases of an allergic reaction to acetylsalicylic acid and serious poisoning are known. For this reason, aspirin should be used with caution in people with asthma. This is explained by the existence of the aspirin variant of bronchial asthma, which occurs in 20-30% of cases among patients with bronchial asthma and is characterized by a very severe course that is difficult to correct.

Aspirin is contraindicated in pregnant women, as it can cause bleeding, with the exception of the need to prevent such a serious pregnancy complication as preeclampsia, which poses a danger to the life of a woman and a child. With preeclampsia, there is a higher blood clotting in the vessels of the placenta, as a result of which the fetus receives less oxygen and all the necessary nutrients. The action of Aspirin, as already mentioned, is aimed at reducing the rate of blood clotting. But such treatment should be carried out exclusively under the supervision of a physician.

The use of Aspirin in the treatment of children under 12 years of age is not recommended. Treatment with Aspirin (as well as other drugs containing acetylsalicylic acid) in children with diseases such as influenza, measles and chickenpox, since Aspirin may increase the risk of Reye's syndrome (a violation of the liver and brain), a dangerous diseases with frequent deaths.

Aspirin: good or bad?

Numerous studies back up aspirin's magical reputation, according to The Daily Telegraph. It seems that scientists nevertheless decided to get to the bottom of the truth, and if there are questions about its 100% effectiveness against heart disease, why not talk about cancer in connection with aspirin? A new study by scientists at the University of Oxford has shown that this medicine, if taken daily for 3-5 years, can reduce the risk of developing cancer by up to 30%. In this case, the drug not only stops the progression of the disease, but also the spread of metastases. In particular, taking 75 mg of aspirin per day for five years or more reduces the risk of developing bowel cancer by a quarter, and mortality from this disease by a third.

Aspirin may prevent the risk of cancer.

Medicines don't help?

Professor Peter Rothwell, who leads the Oxford team, says yes. And Professor Gordon McVie of the European Institute of Oncology in Milan confirms: “There is no doubt that aspirin is cheap and effective.” Peter Elwood, professor of epidemiology at the University of Wales, agrees with them, and is even more confident in the miraculous properties of this drug: "Taking aspirin every day, you increase your chances of a long and productive life, preventing serious diseases."

One of the UK's leading cancer experts, Professor Karol Sikora, says the preventive part of aspirin's miraculous effect has certainly been proven, but he himself is in no hurry to take the drug. Why - and he does not know, he does not have a clear answer. And he, so indecisive, is not the only one among British doctors. One day, Sikora, who was attending a thematic conference in the United States on cancer, asked his colleagues: "Do you take aspirin as a preventive measure for serious diseases?" - 60% answered yes. And at a conference in Britain, only 5% of doctors answered yes to a similar question. Cause? Karol Sikora believes that Americans are by default more concerned about their health than Europeans.

Side effects associated with regular aspirin use are a major risk factor for those who prescribe it for themselves as a panacea. The most important problem discussed in Lately, - disorders of the gastrointestinal tract, which can manifest as pain, and in the most severe cases, aspirin can cause bleeding. “No one can guarantee that you will not experience this when taking this drug,” says Professor Sikora. “If you do not have an ulcer or gastritis in your anamnesis, in all likelihood, side effects will not appear. But if you experience stomach discomfort within a week or two of starting aspirin, talk to your healthcare provider.”

In addition to peptic ulcer disease, other contraindications include hemophilia or bleeding disorders, and allergies to aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and diclofenac. People with asthma, liver disease, kidney disease, digestive problems, pregnant and lactating women should also take aspirin with caution.

But if you still decide to start taking this medicine as a preventive measure, then a natural question arises - when, at what age? Doctors believe that this is definitely worth doing to older people. For example, Dr. Sauvra Whitcroft, a consultant gynecologist at Guildford, recommends aspirin for menopausal women and older, who can take a low daily dose of no more than 75 mg. In this way, Wheatcroft explains, it is possible to reduce the risk of cardiovascular diseases, including, possibly, dementia, since aspirin, by thinning the blood, reduces the likelihood of microscopic blood clots in the blood vessels. It is also known that in women with age, estrogen levels gradually decrease, which can provoke a risk of developing cancer, so taking this drug may be effective. Should middle-aged people take aspirin? This question is still open, if only because cancer has no age restrictions.

How to drink Aspirin - before or after meals

Aspirin is an effective non-steroidal anti-inflammatory drug based on acetylsalicylic acid. In this article, you will learn how to take Aspirin correctly: before or after a meal, and what these conditions are associated with.

Indications for use

Taking pills will be relevant in such cases:

Moderate to severe headaches, migraine attacks;
menstrual pain;
Pain in muscles and joints;
Infectious and inflammatory processes.

Contraindications for use

The instructions say that the medicine can harm the body in such cases:

Ulcerative formations of the stomach;
Gastrointestinal bleeding;
Too thin blood;
Low concentration of vitamin K in the blood;
Liver and kidney failure.

Aspirin is also contraindicated in children under 15 years of age and future mothers in the first and third trimester of childbearing.

Side effects from taking

The drug can provoke:

Nausea and vomiting;
Disorder of the gastrointestinal tract;
Loss of appetite.

How to drink aspirin

To ensure that the drug does not harm it when ingested, you need to remember the following.

Why can't you take aspirin before meals? A tablet taken before a meal can severely damage its mucous membrane. This is due to the fact that acetylsalicylic acid is a serious aggressor and, once on the inner lining of the stomach, can provoke an ulcer at this place. Its acidic action is so strong that it can even corrode blood vessels.

When is the best time to take aspirin after a meal? It is better to drink Aspirin within minutes after eating. This is due to the fact that the stomach will already begin to work and will quickly break down the medicine into useful microelements. Now you know why taking Aspirin after meals is recommended.

How to drink aspirin after a meal? This moment is very important. It is strictly forbidden to drink Aspirin with coffee, tea, milk or freshly squeezed juice. These drinks will only destroy the medicinal structure of the tablet. And some combinations of drinks and medicines can even pose a threat to human life.

The medicine should be washed down with plenty of pure non-carbonated water. This requirement is explained by the fact that the drug is poorly soluble. If you drink little liquid, a small particle of the tablet can stick to the stomach and provoke an ulcer.

For the medicine to work well, it must be drunk three times a day and washed down with large portions of water.

The correctness of taking Aspirin Cardio

Aspirin Cardio is an improved form of the drug designed to protect the human body from myocardial infarction or its consequences. The drug is highly effective, but in order to get the expected result from its use, the patient must adhere to one rule: taking the drug before meals. Acetylsalicylic acid is securely hidden under the capsule, so it will not harm the stomach. This form of Aspirin is also required to be taken with plenty of clean water.

Found an error? Select it and press Ctrl + Enter

How to drink aspirin to thin the blood after 40 years?

Aspirin or acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. In cardiovascular diseases, aspirin is used to thin the blood. To achieve a positive result, the reception must be long and regular.

Causes of blood clotting

Normally, human blood is 90% water. In addition to water, the blood contains erythrocytes, platelets, leukocytes, as well as fats, acids and enzymes. With age, the composition of the blood changes somewhat. The number of platelets increases, but there is less water in it. The blood thickens.

Platelets are involved in the process of stopping bleeding during cuts, provide blood clotting. When there are too many platelets, clots form.

As a result, the lumen of the vessels narrows, making it more difficult for blood to move through them. There is also a risk of blockage of a vessel or heart valve by a detached blood clot. This will lead to immediate death as a result of a stroke or heart attack.

Blood has a particularly thick consistency in the morning, so active physical activity in the morning is not recommended.

There are several reasons for the thickening of human blood:

The result of diseases of the heart and blood vessels
Insufficient water intake
Spleen disorders
Lack of certain vitamins and minerals (vitamin C, zinc, selenium, lecithin)
Taking certain medications
Lots of sugar and carbohydrates in the blood
Hormonal failure in the body

Thus, many factors can lead to blood clots. Therefore, upon reaching the age of 40, it is necessary to donate blood for analysis in order to start diluting it in a timely manner.

Why thin the blood?

Thinning the blood is necessary for everyone who wants to live to a ripe old age. With too thick viscous blood, a large number of blood clots form. Thromboembolism or occlusion of a vessel can lead to instant death.

Timely and regular blood thinning will ensure longevity, as it will reduce the risk of blood clots, and at the same time the risk of developing myocardial infarction and stroke. You will feel better as your blood circulation improves.

The mechanism of action of aspirin

Aspirin or acetylsalicylic acid is a non-steroidal anti-inflammatory drug. The mechanism of action of aspirin is as follows - prostaglandins in the human body are produced in smaller quantities, as a result of which platelets do not accumulate and do not stick together. This reduces the risk of thrombosis and thromboembolism.

Cardiac ischemia
Atherosclerosis
Hypertension
Endarteritis or inflammation of an artery
Thrombophlebitis

The risk group includes people with hereditary diseases of the cardiovascular system and thrombosis, prone to varicose veins and hemorrhoids.

If a tendency to form blood clots is detected on a hemogram (a laboratory blood test for coagulation), acetylsalicylic acid will also be prescribed. All these recommendations, as a rule, concern people after 40 years.

How to drink aspirin to thin the blood?

Before you start taking aspirin to thin your blood, you should consult your doctor. Independent and uncontrolled administration of the drug is unacceptable. The doctor will be able to choose an individual dosage.

It is worth adhering to some rules:

Proper Dosage - Do not take regular aspirin in the dosage that is intended to relieve pain or reduce body temperature. For the prevention of blood clotting, 100 mg of the drug is enough (the fourth part of the tablet). If an urgent restoration of normal blood consistency is required, the doctor may prescribe 300 mg (1 tablet) of acetylsalicylic acid.
Compliance with the regimen - take aspirin daily. The reception time should be the same. This is the only way to achieve sustainable results.
Duration of taking the drug - those who need to thin the blood will have to take aspirin on an ongoing basis.

It is best to take aspirin at night, as the risk of thromboembolism increases at night. Since the drug irritates the mucous membrane of the stomach and intestines, therefore, aspirin should be drunk after meals. It is necessary to drink the medicine with water for better dissolution in the stomach.

The dosage prescribed by the attending physician should not be exceeded, otherwise you can harm your health.

Contraindications

Of course, aspirin is not completely safe. After all, this is a medicine, and any medicine has contraindications. But if you correctly follow the dosage and other recommendations, then the benefits of such an intake of aspirin will be greater than the harm.

Aspirin reduces the risk of heart attack and stroke, but increases the risk of internal bleeding.

Acetylsalicylic acid is contraindicated in pregnant and lactating women. Pregnant women are especially not recommended to take the drug in the first and last trimester, because bleeding may begin, which will either lead to a miscarriage or provoke premature birth.

For children under 12 years of age, aspirin is also contraindicated, as it can lead to the development of Reye's syndrome in a child. To reduce high body temperature, children are prescribed paracetamol.

With a stomach ulcer and duodenal ulcer, aspirin is prohibited.

There are analogues of conventional aspirin for blood thinning:

In analogue preparations, the required dosage of acetylsalicylic acid has already been calculated, so it is convenient to take them.

While watching the video, you will learn about the dose of aspirin.

Thus, aspirin can reduce the risk of developing cardiac pathologies, prolong the life of the elderly. The main thing is to choose the right dosage and be sure to consult with your doctor before taking it.

aspirin dosage

- cup;
- water;
- aspirin.

Take 1 tsp. dry crushed willow bark and pour a glass of boiling water. At elevated temperatures, drink 200 ml of warm broth 4-5 times a day before meals. Tellingly, this drink has no side effects, it is not recommended to abuse it only for pregnant women and nursing mothers. The infusion is prepared according to the same recipe as the decoction, only it is additionally aged in a water bath for minutes. Take 100 ml with meals.

Mash the berries, squeeze out the juice. Pour boiling water over the pulp (what is left after push-ups), cover with a lid and a towel or napkin and let it brew. Add sugar or honey to taste and drink to your health. To complete the taste, you can add fresh juice to the fruit drink. The latter is also suitable as a remedy for colds, but it must be remembered that it contains a large amount of acids, so it should be used with caution (in particular, for people with problems with the gastrointestinal tract), or diluted with water.

What's better

Any form of aspirin has a negative effect on the gastric mucosa if taken before meals. Aspirin should always be taken after meals. Although effervescent tablets do not cause pinpoint ulcers. This can happen if the tablet sticks to the mucosa.

Effervescent aspirin usually tastes good, which can make the healing process easier. In cases where the drug is taken sporadically, you can get by with the usual tableted aspirin. If it needs to be taken regularly, then it is worth using effervescent forms.

What you need to know about acetylsalicylic acid?

Aspirin is an acetyl ester of acetic acid. The drug has an analgesic, antipyretic and antiplatelet effect on the human body. It helps with many diseases.

To date, the mechanism of action of this drug is well understood, which made it possible to include it in the list of essential medicines (according to WHO). The trade name "Aspirin" is patented by Bayer.

Today, among doctors, the dispute does not subside as to whether the use of this drug is beneficial or harmful to the human body. Consider how to take Aspirin with maximum benefit for the body.

The mechanism of action of the drug

What are the indications and contraindications, as well as side effects of the drugs? The drug belongs to non-steroidal anti-inflammatory drugs. It has a pronounced analgesic, anti-inflammatory and antipyretic effect.

At a dosage exceeding 0.3 grams (but not more than 1 gram), Aspirin not only relieves pain, but also lowers body temperature. Therefore, acetylsalicylic acid can be taken for colds, flu, and also to relieve joint pain.

In addition, this medicine inhibits platelet aggregation in humans. Thus, an antiplatelet effect is realized, which determines the indications and contraindications for the use of the drug in a number of cardiac pathologies.

The mechanism of action of the drug is that it inhibits the formation of prostaglandins. These are active substances contained in almost all cells and formed from fatty acids. Taking this medicine reduces inflammation in various organs of the body, pain and fever.

In what cases is the drug used?

Aspirin can be taken in the presence of such indications:

symptomatic relief of headache, toothache, menstrual pain, as well as pain in different parts of the body;
to reduce elevated body temperature during infectious diseases;
in inflammatory diseases.

With caution, you can use Aspirin in cases of such diseases:

gout;
with erosive gastritis;
with increased tendency to bleeding;
if there is a history of stomach or duodenal ulcer;
when the body experiences vitamin K deficiency, as well as anemia;
any conditions that contribute to water retention in body tissues;
thyrotoxicosis.

When is the drug prohibited?

There are no indications for such diseases and phenomena:

severe sensitivity to the main component of the drug;
ulcers of the digestive tract in the acute stage;
bleeding from the digestive tract;
the use of cytostatics;
diathesis;
thrombocytopenia (decrease in the number of blood platelets);
hemophilia;
insufficiency of glycose-6-phosphate dehydrogenase;
pregnancy in the first and third trimester;
lactation;
childhood;
asthma caused by non-steroidal anti-inflammatory drugs.

Taking this medication can cause the following side effects:

Phenomena of dysfunction of the gastrointestinal tract.
Very rarely, liver dysfunction is possible.
Dizziness (occurs in case of overdose).
thrombocytopenia.
Allergic reactions. In rare cases, anaphylactic shock is possible.

Be sure to pay attention to contraindications to taking the drug.

How does aspirin thin the blood?

As mentioned above, the use of Aspirin prevents platelets from sticking together, as a result of which its antiplatelet effect is realized. Due to this property, the drug has indications for blood thinning as a prevention of stroke and cardiovascular disease. After all, when platelets stick together, there is a threat of the formation of a blood clot. And this, in turn, contributes to the development of stroke, cardiovascular diseases.

Mechanism of action of aspirin

In addition, small vessels, as well as capillaries, have a small diameter, as a result of which blood passes through them with difficulty. Aspirin, used to thin the blood, improves circulation.

That is why doctors recommend using Aspirin to thin the blood as a preventive measure against cardiovascular disease. However, the dosage of the drug 0.5 grams or more harms the digestive tract. To thin the blood, you can take much less of this medicine. For preventive purposes, with health benefits, only 0.1 grams of a substance is enough to thin the blood.

Having studied the methods of Olga Markovich in the treatment of strokes, as well as the restoration of speech functions, memory and the removal of constant headaches and tingling in the heart, we decided to bring it to your attention.

The benefits and harms of acetylsalicylic acid

Some people believe that Aspirin is a panacea for all diseases, as a result of which they self-medicate. However, the drug can be not only beneficial, but also harmful to health.

The benefit of Aspirin is that it helps to block the production of prostaglandins. Thus, the manifestation of inflammatory processes in the body is minimized. In addition, the benefit of the drug is that it reduces the risk of platelet aggregation.

The drug is essential for the cores, as it thins the blood. However, self-medication increases the risk of side effects.

The drug is useful only to those people who are at risk for cardiovascular diseases.

To restore the body after a stroke, our readers use a new technique discovered by Elena Malysheva based on medicinal herbs and natural ingredients - Father George's Collection. Collection of Father George helps to improve the swallowing reflex, restores the affected cells in the brain, speech and memory. It also helps prevent recurrent strokes.

The harm from the drug also lies in the fact that it increases the permeability of blood vessels. This reduces the ability of the blood to clot.

How to take the drug correctly?

To reduce the harm from aspirin, it must be drunk after meals and washed down with plenty of water.

It is also allowed to drink the tablets with milk - so the medicine is less harmful. This method is also suitable for those suffering from gastrointestinal diseases.

There are effervescent varieties of Aspirin tablets. They cause less harm to the stomach. People with a tendency to internal bleeding should drink this drug very carefully. But with influenza and chickenpox, it is especially harmful, as the risk of developing hepatic encephalopathy increases.

The method of taking the drug is no more than two tablets of 0.5 grams. The maximum dose per day is no more than 6 such tablets.

Aspirin use in stroke patients

How Much Aspirin Can You Take? Aspirin at a dose of 30 to 150 milligrams per day has been successfully used as a prevention of stroke and cardiovascular disease. A decrease in the frequency of repeated cerebral ischemia by more than 20 percent has been proven. The use of Aspirin in small doses also helps to reduce the likelihood of myocardial infarction, arrhythmias and other cardiovascular ailments.

Important! The benefits of the drug in large doses (0.5 grams or more) are offset by a significant likelihood of side effects.

In particular, the risk of re-development of severe bleeding increases. That is why for the prevention of stroke, coronary heart disease, a dose of 75 milligrams per day is considered effective. Aspirin is dangerous in large quantities. Thus, it is safe to take this drug for stroke prevention.

Can long-term aspirin be indicated?

For long-term use, the drug Aspirin-cardio and its analogues are indicated. It is acceptable to thin the blood in such cases:

for the treatment and prevention of angina pectoris;
prevention and treatment of heart attack;
prophylactic treatment of thrombosis, embolism after vascular operations;
prevention of pathologies of cerebral circulation;
migraine prevention;
prophylactic therapy for thrombosis.

Long-term use may have side effects. When treating with anticoagulants, the presence of gastrointestinal ulcers, renal and hepatic diseases, hypersensitivity to non-steroidal anti-inflammatory drugs, SARS, Aspirin should be used very carefully.

The following side effects are possible:

asthma;
allergic reactions;
decreased uric acid evacuation, which increases the risk of gout;
pain in the stomach;
bronchospasm.

Remember! To avoid these side effects, it is enough to take Aspirin in the minimum effective dose.

In the presence of diseases of the gastrointestinal tract, simultaneous therapy with antacids is acceptable. You can learn how to take Aspirin properly from your doctor.

What laboratory parameters should be monitored while taking Aspirin?

With prolonged use, it is mandatory to control the level of hemoglobin, as well as platelet counts. This is especially true when taking the drug in large doses. Since this drug changes the metabolism of uric acid, all patients should strictly control the biochemical parameters of the blood.

It is also important to monitor the laboratory parameters of urine. This is associated with the risk of developing kidney diseases, up to nephropathy.

Prices for Aspirin in pharmacies in Moscow and St. Petersburg

The cost of Aspirin Cardio, depending on the number of tablets and the manufacturer, varies from 84 to 233 rubles. The average cost of a package of Aspirin Express is 235 rubles, Aspirin Complex in sachets of 3.5 grams is 387 rubles. The average cost of soluble tablets is 250 rubles.

Aspirin is a highly effective drug that helps not only to reduce fever and fight pain, but also to prevent stroke. However, it should only be taken as directed by a doctor.

How to take aspirin to thin your blood

Acetylsalicylic acid or, simply, aspirin is one of the most famous drugs in the world. Aspirin has a wide spectrum of action - it is an analgesic, anti-inflammatory and antipyretic medicine. This medicine was opened for wide use more than two centuries ago, but it is still in demand and popular. Aspirin is often used to thin the blood of people suffering from cardiovascular disease. Today, long-term and daily use of aspirin is an integral part of the life of an elderly person.

What is "thick" blood

In the blood of a healthy person, there is a balance of red blood cells, white blood cells, platelets, various fats, acids and enzymes, and, of course, water. After all, blood itself is 90% water. And, if the amount of this water decreases, and the concentration of other components of the blood increases, the blood becomes viscous and thick. This is where platelets come into play. Normally, they are needed in order to stop bleeding; when cut, it is platelets that clot the blood and form a crust on the wound.

If there are too many platelets for a certain volume of blood, clots can appear in the blood - blood clots. They, like growths, form on the walls of blood vessels and narrow the lumen of the vessel. This impairs the permeability of blood through the vessels. But the most dangerous thing is that a blood clot can come off and get into the heart valve. This leads to the death of a person. Therefore, it is very important to monitor your health if you are already 40 years old. It is necessary to donate blood for analysis and consult a doctor. You may already need to take aspirin to thin your blood.

Young people under 40 can also take aspirin. It depends on the state of your body at the moment. If you have poor cardiac heredity in your family - your parents suffered from heart attacks and strokes, if you have hypertension, you must definitely monitor the density of your blood - donate blood for analysis at least every six months.

Causes of blood clotting

Normally, blood has a different density during the day. In the morning, it is very thick, so doctors do not recommend immediately after waking up to engage in active physical activity. Running in the morning can lead to a heart attack, especially in unprepared people.

The causes of blood clotting can be different. Here are some of them:

Thick blood can be the result of cardiovascular diseases.
If you drink little water, this can also cause blood clots. This is especially true for people living in hot climates.
Malfunctioning of the spleen is a common cause of blood clotting. And, also, the blood can thicken from harmful radiation.
If the body lacks vitamin C, zinc, selenium or lecithin, this is a direct path to thick and viscous blood. After all, it is these components that help water to be properly absorbed by the body.
The viscosity of the blood can be increased due to the intake of certain medications, because most of them affect the composition of the blood.
If your diet contains a large amount of sugar and simple carbohydrates, this can also be the main cause of blood clots.

Aspirin can significantly improve the condition of your blood, however, to achieve a real result, the drug must be taken for a long time. Aspirin is taken as a treatment or prophylaxis. If, with the help of aspirin, the doctor intends to restore the normal consistency of the blood in a short period of time, they prescribe mg of aspirin per day, that is, one tablet.

The prophylactic dose does not exceed 100 mg, which is a quarter of a standard aspirin tablet. Aspirin is best taken before bed because the risk of blood clots increases at night. This medicine should not be taken on an empty stomach, as this may cause stomach ulcers. Aspirin must be dissolved on the tongue and then washed down with plenty of water to avoid problems with the gastrointestinal tract. Do not exceed the dose prescribed by a specialist - this can lead to serious health problems. And further. This medicine should be permanent and lifelong. Aspirin helps to thin the blood, which is so necessary for people in old age with heart disease.

Aspirin is an effective medicine, but it has a number of contraindications. Acetylsalicylic acid should not be taken by pregnant women, especially in the first and last trimesters. Taking aspirin during the first three months of pregnancy is dangerous because it can cause fetal defects. In the last three months of pregnancy, aspirin can cause bleeding and, as a result, premature birth.

Also, aspirin should not be taken by children under 12 years of age. Recent studies by scientists have led to the conclusion that aspirin intake by young children may be the cause of the development of Reye's syndrome. As an antipyretic and analgesic analogue, it is better to take drugs containing paracetamol and ibuprofen in their composition.

Aspirin should not be taken by people who have problems with blood clotting. Also, aspirin is contraindicated in patients with peptic ulcer of the stomach and duodenum.

Acetylsalicylic acid can be released as part of other drugs. They contain a special necessary prophylactic dose and are more adapted to the body. Among them are Cardiomagnyl, Aspirin-cardio, Aspecard, Lospirin, Warfarin. Your doctor will help you choose the right medicine. Self-medication in this case is not recommended, because aspirin can be dangerous. It is even banned in some Western countries.

If old age has overtaken you or your parents, this is an occasion to undergo an examination and, if necessary, start taking aspirin. After all, only taking care of your health and regularity of taking medicines can give you a long life without diseases.

There are no harmless medicines. And Aspirin is no exception. The list of contraindications attached to any drug, as a rule, is much longer than the list of diseases for which its use is justified. You can never be sure that the pills that save one will not kill another.

When is aspirin warranted?

Aspirin is a fairly popular drug. Many have it in their home first aid kit and take it without a doctor's prescription, guided, at best, by instructions, at worst, by the advice of friends and acquaintances. It is believed that Acetylsalicylic acid is practically harmless. It is added to the brine when canning vegetables and is also saved from a hangover.

Daily intake of Aspirin is indicated for the following diseases:

atherosclerosis
previous stroke or myocardial infarction
angina pectoris
postoperative period of coronary artery bypass grafting
diabetes mellitus with a risk of developing cardiovascular pathologies
obstruction (obliteration) of peripheral arteries

Acetylsalicylic acid is prescribed as a prevention of heart attacks and strokes. Sometimes people, fearing these formidable pathologies, begin to take Aspirin on their own, without a doctor's prescription. This cannot be done.

Regular low-dose aspirin reduces the risk of stroke or heart attack in a limited number of patients. This is evidenced by the latest conclusions made by the FDA (US government agency in the health system), based on numerous studies.

Such a precaution is effective only in preventing recurrent attacks and is absolutely useless as their primary prevention. Aspirin reduces the chance of blood clots that can block coronary arteries or cerebral vessels.

However, studies proving the validity of the daily intake of Acetylsalicylic acid without a history of cardiac pathologies do not exist. While the risks from its regular use are significant.

There is evidence that low-dose aspirin increases the chances of survival in patients with colon cancer.

Long-term courses of treatment or prophylaxis using Aspirin should be prescribed and under the supervision of a physician. Only a specialist on the basis of the conducted studies can weigh the pros and cons of such therapy and prescribe the optimal dosage of the drug. And for each person it will be strictly individual.

Who should not take acetylsalicylic acid

With prolonged use of Aspirin, the number of platelets, colorless blood cells that are responsible for blood clotting, decreases. This can cause bleeding, including internal bleeding. In this connection, the drug is not recommended during menstruation.

Acetylsalicylic acid often causes erosive damage to the gastrointestinal tract, leading to peptic ulcer. People who already suffer from these diseases, its use is strictly contraindicated.

Today, enteric tablets of Acetylsalicylic acid (Aspirin-Cardio, Thrombo ACC and their analogues) are heavily advertised. The popularity of such drugs is due to their supposedly low ability to influence the formation of erosions and ulcers.

However, this is not quite true. Confidence in the safety of enteric tablets is beneficial to maintain among the population the manufacturers of this form of medicine and, in particular, the Bayer company, which brought a new product to the market. Such drugs are much more expensive than uncoated counterparts, and the risks for the gastrointestinal tract are the same.

The negative effect of Aspirin on the stomach is not only a local irritant effect. It does not matter how the drug enters the bloodstream, what matters is what changes in the body it leads to.

Undesirable consequences in the form of damage to the gastric mucosa are due to the influence of acetylsalicylic acid on its protective functions. Regular intake of Aspirin, even in small doses, increases the risk of macular degeneration in the retina in the elderly. As a result, this can lead to complete loss of vision.

Do not prescribe Aspirin to people with chronic liver and kidney diseases, allergies, pregnant women and children under 12 years of age. It is worth refusing to take the drug for a long time in patients suffering from an enlarged thyroid gland, arterial hypertension (high blood pressure), and asthma.

You can not take Acetylsalicylic acid with a tendency to abuse alcohol. Alcohol damages the lining of the stomach, and Aspirin greatly enhances this effect, increasing the risk of internal bleeding.

While watching the video, you will learn about the benefits and harms of aspirin.

In some situations, regular use of Aspirin prolongs life. Uncontrolled long-term use of Acetylsalicylic acid can end tragically and cause irreparable harm to health. To decide whether it is reasonable or not to use the drug in each case, the doctor should.

Aspirin for blood thinning

Everyone knows that excessive blood density is dangerous; and most choose aspirin as their primary remedy for this problem. This drug has a wide spectrum of action, so it is prescribed very often. Due to the fact that the side effects on the body from taking aspirin are mild, therapy can last for a very long time. It is for this reason that older people often take this drug regularly for many years. Aspirin appeared back in the 19th century in Germany and was initially used as an anesthetic for rheumatism, but very soon other beneficial effects of the drug were revealed, which is why it gained immense popularity. To date, aspirin and medicines based on it are the most purchased in the world. In order to thin the blood with aspirin and not harm the body, you should know about all the intricacies of taking this medication with increased blood viscosity.

What can cause blood clots

An increase in blood viscosity can occur for many reasons. The very mechanism of blood clotting is a sharp increase in the concentration of platelets with a decrease in the volume of water (which normally makes up 90% of the blood). Most often, such an imbalance in the composition of the blood occurs in people over 40 years old, when certain failures are increasingly occurring in the body. During the day, the density of the blood changes, which is a natural process that does not require treatment. Blood acquires maximum density in the morning, which is why doctors today strongly do not recommend exposing your body to physical exertion in the morning, which can lead to the development of a heart attack and stroke. The optimal time for sports is the period from 15 to 21 hours.

Pathological thickening of the blood in the body is caused by the following reasons:

diseases of the cardiovascular system;
eating too much sugar;
eating too many carbohydrates;
violations of the spleen;
insufficient fluid intake;
deficiency of vitamin C in the body;
selenium deficiency in the body;
deficiency of lecithin in the body;
the use of certain medications.

Regardless of what caused the blood to thicken, such a pathology should certainly be fought. Otherwise, there is a high risk that the blood clots formed in the vessels at some point will come off and clog the arteries or the aorta, which will lead to the death of the patient. In addition, increased blood viscosity has a very negative effect on the functioning of the brain, leading to the fact that its tissues begin to break down due to oxygen deficiency and senile dementia is formed.

The mechanism of action of aspirin in blood thinning

In order to understand why aspirin has become one of the best blood thinning drugs, one should understand the principle of its action on the body. The basis of the drug is acetylsalicylic acid, which is included in the group of non-steroidal anti-inflammatory drugs. This substance has a blocking effect on the synthesis of prostaglandins, which are responsible for the activation of the process of thrombosis in the body, in which there is a rapid adhesion of platelets to each other and clogging of the damaged vessel. When the work of the body fails and active thrombosis occurs without damage to the vessels, then platelet clots are deposited on the walls of the vessels. Under the influence of aspirin, the production of prostaglandins is reduced and thus platelet aggregation is prevented. As a result, the risk of blood clots on the walls of blood vessels is greatly reduced.

What are the indications for using aspirin as a blood thinner?

Aspirin is prescribed to thin the blood for a variety of conditions. Indications for its reception are:

thrombophlebitis - inflammation of the walls of the veins, in which there is stagnation of blood and the formation of blood clots. Most often, this disease affects the veins of the lower extremities;
coronary heart disease - this disease is characterized by impaired blood supply to the tissues of the heart muscle, caused by the formation of atherosclerotic plaques in the coronary arteries;
inflammation of the arteries (of any localization) - the use of aspirin is necessary for the reason that when blood passes through the inflamed area, the platelet adhesion process is sharply activated and the risk of developing a blood clot is very high;
hypertension - with constantly elevated pressure, even a small blood clot threatens to rupture a vessel and cause a stroke. In this state, taking aspirin is vital;
cerebral sclerosis - with this violation in the process of blood supply to the brain, blood clots are very easily formed on the walls of the vessels of the organ;
blood test indicators indicating increased clotting caused by the individual characteristics of the patient's body.

It is precisely because aspirin is often used to thin the blood in diseases that occur predominantly in old age that many consider it an essential drug for all people in years, which is not entirely true. Treatment with aspirin must be prescribed by a doctor.

How to take aspirin to thin your blood

In order for the drug to effectively prevent thrombosis and at the same time not lead to excessive blood thinning, you should know the features of its use.

The dosage of the drug plays a crucial role in the regulation of thrombosis. In the event that aspirin is prescribed to prevent the development of increased blood viscosity while taking medications, the dosage is only 100 mg per day.

When the drug is required to treat increased blood density and dissolve blood clots, then its dosage is increased and may, at the discretion of the attending physician, be from 300 to 500 mg.

Take a pill once a day strictly at the same time. It is recommended to drink aspirin at 19:00, since at this time the body is already beginning to switch to a rest mode and the medicine will be absorbed faster. It is strictly forbidden to use aspirin on an empty stomach, since in this case it can provoke the development of a stomach ulcer due to the content of acid in its composition.

The duration of the course of taking the drug is determined by the attending physician, depending on the indicators of the tests and the general condition of the patient. Also, only a doctor determines the possibility of taking aspirin to thin the blood during pregnancy and breastfeeding.

Contraindications to taking aspirin

Despite the popularity of aspirin, before using it, you should familiarize yourself with the contraindications. There are a lot of them, and to be completely sure that the therapy will benefit, it is better to consult a doctor. It is necessary to stop taking aspirin in such cases:

children's age is less than 12 years;
tendency to bleed;
intolerance to acetylsalicylic acid;
bronchial asthma;
diseases of the gastrointestinal tract;
blood diseases;
liver disease;
kidney disease;
period before and after surgery;
extensive burns.

Before starting treatment with aspirin, it is necessary to familiarize yourself in detail with the rules for taking it and contraindications.

Aspirin - benefits and harms to the body

Acetylsalicylic acid was first synthesized in the middle of the XIX century. For medical use, the drug was obtained in the laboratory of the German company Bayer AG in 1897. From here he began his victorious march, having received the name "Aspirin". Willow bark served as the initial raw material for it. Currently, aspirin is produced chemically. At first, only the antipyretic effect of the drug was known. Then, during the twentieth century, physicians discovered its new properties.

For a long time, aspirin was considered absolutely safe and was even recommended for preventive purposes. Today, the opinions of doctors on this issue are divided. What are the benefits and harms of aspirin? How to use it and who should not be treated with acetylsalicylic acid? Is aspirin poisoning possible?

How does aspirin work

Today, acetylsalicylic acid has been studied thoroughly. Extensive experience in clinical trials has been accumulated. The drug belongs to the most important drugs and is included in the list of indispensable drugs both in Russia and according to WHO recommendations.

Such popularity of acetylsalicylic acid is explained by the fact that, with a minimum of side effects, it has antipyretic, analgesic, anti-inflammatory, antirheumatic and antiplatelet effects. The drug belongs to the group of non-steroidal anti-inflammatory drugs. It inhibits the synthesis of thromboxanes and prostaglandins, and unlike other drugs from this group (diclofenac, ibuprofen), it does this irreversibly.

The antipyretic property of aspirin is based on the effect of the drug on the thermoregulatory center in the brain. Under the influence of acetylsalicylic acid, blood vessels dilate and sweating increases, which leads to a decrease in body temperature.
The analgesic effect is achieved both by direct action on mediators in the area of inflammation, and by the effect on the central nervous system.
Antiaggregant action, - blood thinning, is caused by the effect on platelets. Aspirin prevents them from sticking together and forming blood clots.
The anti-inflammatory effect is achieved by reducing the permeability of small vessels in the focus of inflammation, inhibiting the synthesis of inflammatory factors, and limiting access to cell energy resources.

Acetylsalicylic acid is available in tablets; abroad - in powders and candles. Based on salicylates, many drugs with a similar effect have been created. A large number of combined drugs are also produced: Citramon, Askofen, Coficil, Acelizin, Asfen and others.

Aspirin use

Indications for the use of acetylsalicylic acid are as follows:

increased body temperature in infectious and inflammatory diseases;
pains of weak and moderate intensity of different origin (headache, myalgia, neuralgia);
primary and secondary prevention of myocardial infarction;
prevention of the formation of blood clots and emboli;
rheumatism and rheumatoid arthritis;
myocarditis of infectious and allergic origin;
prevention of circulatory disorders in the brain by ischemic type.

How to take aspirin? For long-term treatment, the medicine must be prescribed by a doctor. Doses are selected individually, as the therapeutic range is quite wide.

Adult patients are prescribed from 40 mg to 1 g per reception. The daily dosage ranges from 150 mg to 8 grams. Take aspirin 2-6 times a day, after meals. Tablets should be crushed and washed down with plenty of water or milk. To reduce the negative impact on the gastric mucosa during long-term treatment with aspirin, it is recommended to drink it with alkaline mineral waters.

If the medicine is taken without medical supervision, then the duration of the course should not exceed 7 days as an anesthetic and 3 days as an antipyretic.

Contraindications for use

Is aspirin harmful? Of course, like any medicine, it has its own contraindications for use:

peptic ulcers of the stomach and intestines;
bleeding in the organs of the gastrointestinal tract;
previously observed allergic reactions to acetylsalicylic acid;
reduced number of platelets in the blood;
vitamin K deficiency;
hemophilia;
portal hypertension;
exfoliating aortic aneurysm;
first and third trimesters of pregnancy;
lactation;
liver failure;
kidney failure;
before surgical interventions.

Use the drug with caution in patients predisposed to the accumulation of uric acid in the body (gout). Even in small doses, aspirin delays the release of this substance, which can cause a gout attack.

Harm from aspirin

The medicine can also cause harm if the dosage is incorrect or as a result of interaction with other drugs. The negative impact on the body of aspirin is the following factors.

Salicylates act on the gastric mucosa and can cause ulceration.
A decrease in blood clotting under certain conditions leads to bleeding in the stomach and intestines, during surgical interventions, with heavy menstruation.
Aspirin has a teratogenic effect on the developing fetus (causes deformities), therefore it is prohibited for use in pregnant women.
In acute viral diseases in children under 12-15 years of age, such as measles, smallpox, influenza, aspirin treatment can provoke hepatic encephalopathy (a disease that destroys liver and brain cells). The pathology was first described in the United States and was called Reye's syndrome.

Sometimes doctors prescribe Aspirin Cardio during pregnancy. This is usually done in order to reduce blood clotting or prevent heart disease. In this case, it is necessary to weigh the benefits of the drug and the possible harm from it in relation to the mother and child.

It is forbidden to combine the intake of aspirin and alcohol. This combination is fraught with gastric bleeding. But with a hangover syndrome, aspirin is taken as an anesthetic and blood thinner, it is part of many pharmaceutical hangover remedies.

Acetylsalicylic acid can cause allergies like bronchial asthma. The symptom complex is called the "aspirin triad" and includes bronchospasm, nasal polyps, and intolerance to salicylates.

The benefits of aspirin and the harm - what more?

In the debate on the benefits and harms of aspirin, various facts are voiced. So, according to studies conducted in the United States, regular intake of aspirin reduces the risk of developing:

bowel cancer by 40%;
prostate cancer by 10%;
lung cancer by 30%;
oncology of the throat and esophagus by 60%.

According to other data, in people aged 50 to 80 years who are prone to heart disease, with regular use of acetylsalicylic acid, life span is extended, and mortality from these diseases is 25% lower compared to the control group.

Cardiologists say that the benefits of taking aspirin in cardiovascular pathologies are immeasurably greater than the possible harm. This largely applies to women during menopause, in which the drug improves blood circulation, reduces the likelihood of thrombosis and the risk of developing atherosclerosis.

At the same time, there are also disturbing publications. According to a group of researchers in the United States, more than 16,000 people die every year from uncontrolled use of aspirin. Finnish doctors have published data showing that taking acetylsalicylic acid doubles the mortality after suffering a cerebral hemorrhage (compared to those patients who did not use aspirin). Historians have put forward a version that the high mortality from the "Spanish flu" in 1918 is associated with the massive use of aspirin in large doses (10-30 grams each).

What is more in aspirin - benefit or harm? Like any drug, acetylsalicylic acid should be used only if there are indications for its use. With a number of diseases: an increase in blood clotting, a tendency to thrombosis, disorders of the heart - taking aspirin for a long time is fully justified. The dose must be discussed with the attending physician, he will also prescribe studies that control the side effects of the drug.

You can not take acetylsalicylic acid if there are contraindications: pregnancy, children under 15 years of age, acute viral diseases with high fever, ulcerative lesions of the stomach and intestines. It is forbidden to combine the intake of aspirin and alcoholic beverages, as this combination enhances the negative effect of the drug on the gastric mucosa and can lead to ulceration and bleeding.

Probably everyone knows that in the heat you need to drink an Aspirin tablet. Many do this without even thinking about the full spectrum of action of this drug, its consequences and contraindications. You can often see how Aspirin is drunk in films, advertisements, modern books, and you yourself could often resort to it, simply because everyone does it. Meanwhile, its active substance has not yet been fully studied, therefore, you should warn yourself and get better acquainted with the instructions for this drug. In this article, you will learn when it is better to take Aspirin, and when to stop it, see its spectrum of action and possible side effects.

How Aspirin Works

Otherwise, this drug is called acetylsalicylic acid and has the abbreviation ASA. In pharmacies, you can find both Aspirin and tablets called ASA.

Its main action is antipyretic. The drug stimulates sweating, which contributes to a rapid decrease in body temperature.
Aspirin has an anti-inflammatory effect to a lesser extent than antipyretic, but it is strongly pronounced. Due to the fact that the drug fights inflammation, it well relieves the patient from pain. However, you need to understand well where this source of pain comes from and why it started.
In addition to the well-known actions, Aspirin also replenishes the reserves of vitamin C in the body, which is very important during periods of colds and flu. Vitamin C is able to raise many people to their feet, without even resorting to serious drugs. This will keep your stomach healthy and free you from heavy spending on medicines.
One of the controversial actions of aspirin is blood thinning. For some situations, this effect becomes a big plus, but in others - irreparable damage to the body.
Of the secondary effects, an increase in the acidity of the stomach can be distinguished. This is very important if you are suffering from stomach ailments, especially ulcers.

When to take Aspirin

Here is the answer to the main question - what will Aspirin help from? Now that you have familiarized yourself with the spectrum of action of this pill, we can draw conclusions:

Drinking ASA is better when it's hot, but if the body temperature is not lower than 37.1 degrees, all temperatures below this mark may be the norm for a particular person.
With inflammation, Aspirin is taken as an anesthetic and relieves swelling.
Headache most often goes away after an Aspirin tablet.
Sometimes Aspirin is prescribed for some problems with blood vessels and circulatory disorders in the brain.
During SARS, he becomes an indispensable assistant with the main symptoms.

However, first you need to familiarize yourself with the contraindications in the next paragraph, and also find out the dosage of the drug. If you drink aspirin too often and too much, then you may develop stomach pain. This drug strongly destroys the gastric mucosa.

Contraindications to taking aspirin

These include:

Ulcers and diseases of the stomach. With them, Aspirin is strictly prohibited.
Many vascular diseases, as the tablet thins the blood.
Age up to twelve years.
Pregnant women are most often prohibited from taking Aspirin.
If you are taking several drugs at the same time, it is better for you to consult your doctor, as some pills are not allowed to be mixed with each other, Aspirin is also included in this list.
Diseases of blood clotting.

If you do not have any of the above, then you can safely put the drug in your first aid kit and refer to it if necessary.

Instruction

People suffering from hereditary blood diseases, aspirin is categorically contraindicated. Patients with diseases of the gastrointestinal tract, liver and kidneys, as well as it is better to refrain from taking this drug. Small children (under 3 years old) should not be given aspirin either.

When aspirin is used as an anti-inflammatory and analgesic in the treatment of joint diseases (arthritis, arthrosis), the selection of a single and daily dosage should be based on such an indicator as the effectiveness and duration of pain relief. In most cases, a single dose is from 0.5 to 1 g, and the maximum daily dose should not exceed 3 g.

If aspirin is used to relieve a migraine attack, a single dose is 1 g. Depending on the patient's condition, the same dose can be taken 1-2 more times during the day. The maximum daily dose varies within 3 g.

In the case when aspirin is used for (in the prevention of a recurrent heart attack, for example), it is recommended to take it 3 times a day, 100 mg each.

Most doctors and pharmacists recommend taking aspirin shortly after meals, preferably in powder form (for quick and efficient absorption by the body). To minimize the harmful effects of acetylsalicylic acid on the stomach, it is necessary to drink aspirin powder with plenty of liquid. You can also use a soluble form of aspirin (called effervescent aspirin).

Types of aspirin

If your doctor has prescribed you a specific form of aspirin release, such as Aspirin-Cardio or Aspirin-C (with vitamin C), then there is one and this form will be the most optimal. In the case when you want to take aspirin of another brand, in your medicine cabinet there is a medicine of a different form of release, you should tell your doctor about it. Most often, the issue is resolved in favor of the wishes of the patient, since in any case the active substance is always the same - acetylsalicylic acid.

In this article, you can read the instructions for using the drug Aspirin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Aspirin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Aspirin analogues in the presence of existing structural analogues. Use to thin the blood, relieve pain and fever in adults, children, as well as during pregnancy and lactation. Various forms of aspirin - cardio (heart form), upsa and release forms in the form of effervescent tablets to reduce the harmful effects on the gastrointestinal mucosa.

Aspirin- non-steroidal anti-inflammatory agent. Antiaggregant. The mechanism of the antiplatelet action of acetylsalicylic acid (ASA - the active ingredient of Aspirin) is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, because. they are unable to resynthesize cyclooxygenase. It is believed that ASA also has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases.

ASA also has anti-inflammatory, analgesic and antipyretic effects, due to the inhibition of cyclooxygenase enzymes involved in the synthesis of protaglandins.

Pharmacokinetics

When taken orally, it is rapidly absorbed mainly from the proximal small intestine and, to a lesser extent, from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.

About 80% of salicylic acid binds to plasma proteins. Salicylates easily penetrate into many tissues and body fluids, incl. into the cerebrospinal, peritoneal and synovial fluids. Small amounts of salicylates are found in the brain tissue, traces - in bile, sweat, feces. It quickly crosses the placental barrier and is excreted in small amounts in breast milk.

Penetration into the joint cavity accelerates in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.

It is excreted mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. In newborns, the elimination of salicylate is much slower than in adults.

Indications

rheumatism;
rheumatoid arthritis;
infectious-allergic myocarditis;
fever (fever) in infectious and inflammatory diseases;
pain syndrome of low and medium intensity of various origins (including neuralgia, myalgia, headache);
prevention of thrombosis and embolism (the so-called blood thinning);
primary and secondary prevention of myocardial infarction;
prevention of cerebrovascular accidents by ischemic type.

Release form

Tablets 100 mg and 500 mg.

Tablets 100 mg and 300 mg (Aspirin cardio).

Effervescent water-soluble forms of aspirin tablets - 500 mg (Upsarin UPSA, Aspirin 1000).

Instructions for use and dosage

Individually. For adults, a single dose varies from 40 mg to 1 g, daily - from 150 mg to 8 g; frequency of use - 2-6 times a day.

For adults, a single dose is 100 mg, the recommended daily dose is 300 mg (3 tablets per day). Aspirin should preferably be taken after a meal with plenty of water. The course of treatment should not exceed 7-10 days in the absence of undesirable side effects. Longer therapy requires consultation of the attending physician.

The appointment of Aspirin to children is possible only after consulting a doctor, taking into account the possible risk of developing Reye's syndrome, a very rare, life-threatening condition, accompanied by the development of encephalopathy and fatty degeneration of the liver. Recommended doses for children: from 2 to 3 years - 100 mg / day (1 table), from 4 to 6 years - 200 mg / day (2 tables), from 7 to 9 years - 300 mg / day (3 tables .).

Side effect

nausea, vomiting;
anorexia;
pain in the epigastrium;
diarrhea;
the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract;
liver dysfunction;
dizziness;
headache;
noise in ears;
thrombocytopenia, anemia, leukopenia;
impaired renal function;
nephrotic syndrome;
skin rash;
angioedema;
bronchospasm;
"aspirin triad" (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs);
Reye's syndrome.

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
gastrointestinal bleeding;
"aspirin triad";
a history of indications of urticaria, rhinitis caused by taking acetylsalicylic acid and other NSAIDs;
hemophilia;
hemorrhagic diathesis;
hypoprothrombinemia;
dissecting aortic aneurysm;
portal hypertension;
vitamin K deficiency;
hepatic and / or renal failure;
deficiency of glucose-6-phosphate dehydrogenase;
Reye's syndrome;
children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases);
1st and 3rd trimesters of pregnancy;
lactation period;
hypersensitivity to acetylsalicylic acid and other salicylates.

Use during pregnancy and lactation

Contraindicated for use in the 1st and 3rd trimesters of pregnancy. In the 2nd trimester of pregnancy, a single dose is possible according to strict indications.

It has a teratogenic effect: when used in the 1st trimester, it leads to the development of a splitting of the upper palate, in the 3rd trimester it causes inhibition of labor activity (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.

Aspirin is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function, therefore, acetylsalicylic acid should not be used in the mother during lactation.

special instructions

Use with caution in patients with diseases of the liver and kidneys, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in history, with increased bleeding or while conducting anticoagulant therapy, decompensated chronic heart failure.

Aspirin, even in small doses, reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When carrying out long-term therapy and / or the use of acetylsalicylic acid in high doses, a doctor's supervision and regular monitoring of hemoglobin levels are required.

The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 mg is limited due to the high likelihood of side effects from the gastrointestinal tract.

Before surgery, to reduce bleeding during surgery and in the postoperative period, salicylates should be discontinued 5-7 days in advance.

During long-term therapy, it is necessary to conduct a complete blood count and a study of feces for occult blood.

The use of aspirin in pediatrics is contraindicated, since in the case of a viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye's syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.

The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days as an antipyretic.

During the treatment period, the patient should refrain from drinking alcohol.

drug interaction

With the simultaneous use of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce the absorption of aspirin.

With the simultaneous use of calcium channel blockers, agents that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.

With simultaneous use with aspirin, the effect of heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulins, methotrexate, phenytoin, valproic acid is enhanced.

With simultaneous use with glucocorticosteroids, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.

With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.

With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid may reduce plasma concentrations of indomethacin, piroxicam.

When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.

With simultaneous use, the effectiveness of uricosuric agents (including probenecid, sulfinpyrazone, benzbromarone) decreases.

With the simultaneous use of acetylsalicylic acid and sodium alendronate, severe esophagitis may develop.

With the simultaneous use of griseofulvin, a violation of the absorption of acetylsalicylic acid is possible.

With the simultaneous use of dipyridamole, an increase in Cmax of salicylate in plasma and AUC is possible.

With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in the blood plasma increase.

With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.

Acetylsalicylic acid at doses less than 300 mg per day has little effect on the effectiveness of captopril and enalapril. When using acetylsalicylic acid in high doses, it is possible to reduce the effectiveness of captopril and enalapril.

With simultaneous use, caffeine increases the absorption rate, plasma concentration and bioavailability of acetylsalicylic acid.

With simultaneous use, metoprolol can increase the Cmax of salicylate in plasma.

When using pentazocine against the background of long-term use of aspirin in high doses, there is a risk of developing severe adverse reactions from the kidneys.

With the simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.

With the simultaneous use of ethanol (alcohol) can enhance the negative effect of aspirin on the gastrointestinal tract.

Analogues of the drug Aspirin

Structural analogues for the active substance:

Anopyrin;
ASK-cardio;
Aspicor;
Aspinate;
Aspirin 1000;
Aspirin Cardio;
Acecardol;
Acenterin;
Acetylsalicylic acid;
Acetylsalicylic acid Cardio;
Acylpyrine;
Acsbirin;
Bufferin;
Zorex Morning;
Cardiask;
Colfarite;
Mikristin;
Taspir;
Thrombo ASS;
Trombopol;
Walsh-asalgin;
Upsarin UPSA.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.