What happens if you drink a lot of aspirin. What does an overdose of aspirin entail, and how to provide first aid for poisoning

Preparations from the group of aspirins and their analogues are quite popular among the population of our country and are widely used as an analgesic, antipyretic and blood thinner. Aspirin (acetylsalicylic acid) tablets can be found in any home medicine cabinet, and almost no one doubts the safety of their use. Although such a harmless medicine can be poisoned. With a significant excess of the recommended doses and with prolonged use of the drug, an overdose of Aspirin may occur. Without detracting from the usefulness of this drug, let's not forget that everything is good in moderation. How can an overdose occur?

How does aspirin affect the human body?

Aspirin belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), the action of which is based on the properties of acetylsalicylic acid.

These properties are manifested by analgesic, antipyretic and, of course, anti-inflammatory effects.
Thanks to Aspirin, platelet aggregation in the blood decreases, preventing the formation of their clusters - blood clots. That is why Aspirin is almost always prescribed to people suffering from cerebrovascular accidents, angina pectoris and other pathologies of the cardiovascular system.
In addition, it is prescribed to patients diagnosed with atherosclerosis in order to prevent complications from the heart.
Finally, Aspirin is most often used in the treatment of acute respiratory viral infections with high body temperature, with various pain syndromes, and migraines.

The drug is almost completely absorbed by the digestive tract, decomposed in the liver and excreted by the kidneys. The list of side effects indicated in the annotation to the drug describes several dozen conditions associated with disruptions in the functioning of internal organs and systems. However, all of them, as a rule, occur when the recommended dosage of the drug is not observed.

Why you can get poisoned by aspirin

Usually, if the therapeutic dosage is observed and the patient has no contraindications, Aspirin shows almost no side effects and is well tolerated by patients. But large doses of the drug, especially with prolonged use, have a toxic effect on the body. As a result of an overdose, aspirin poisoning may occur. This can happen in the following cases:

with self-treatment with a drug that does not take into account the dosage, contraindications and other recommendations prescribed in the instructions for use;
if a small child found a package lying unattended and ate pills;
rarely - with the intentional taking of large doses of the drug in order to accelerate the therapeutic effect or for another purpose;
with a significant violation of the activity of the kidneys or liver, which the person taking Aspirin might not know about.

Depending on the amount of medication taken and the duration of exposure, aspirin poisoning can be acute or chronic.

Clinical picture of chronic poisoning

The symptoms of chronic poisoning with acetylsalicylic acid are quite difficult to recognize, as they are similar to the clinical picture of many chronic diseases. Only attentive households who have noticed a rapid reduction in the number of tablets in a package can suspect an overdose. If this circumstance is confirmed by the following symptoms, the victim needs immediate medical attention. Signs of intoxication may appear:

headache;
nausea, vomiting;
increased sweating;
hearing loss, "stupor";
pain in the stomach;
indigestion;
tinnitus;
anemia, a decrease in the level of platelets and leukocytes in the blood;
loss of consciousness.

Chronic overdose can cause drug-induced asthma and bleeding, and prolonged overdose can increase symptoms of heart failure and other dangerous consequences. The level of Aspirin in the blood plasma in chronic poisoning ranges from 150 to 300 mcg / l.

Signs of acute aspirin intoxication

With a single intake of high doses of Aspirin in the human body, acute poisoning occurs. Depending on the strength of the toxic effect, it can be of three degrees of severity.

Mild degree of poisoning

A mild degree of poisoning is usually manifested by signs characteristic of chronic intoxication, in addition to loss of consciousness by the victims. The content of the drug in the blood in acute poisoning of mild severity does not exceed 150 mcg / l.

Average degree of poisoning

With an average severity of an overdose, rapid and difficult breathing, cough with mucous sputum, fever are observed. Important internal organs may also be affected to some extent. The level of traces of the drug in the blood with an average degree of intoxication is 300-500 mcg / l.

Severe degree of poisoning

A severe degree of poisoning with acetylsalicylic acid is manifested by respiratory failure, turning into pulmonary edema. The victim's breathing becomes even more frequent, the cough intensifies, the skin turns pale, and then turns blue (cyanosis). The appearance of foam at the mouth indicates the critical condition of the poisoned person, from which it will be almost impossible to remove him. The consequences of further intoxication are manifested by the following conditions:

Due to impaired renal activity, urination decreases.
In the blood, the electrolyte balance is disturbed, which is life-threatening for the victim - the level of sodium in the plasma rises, and that of potassium decreases.
Toxic encephalopathy may develop, the progression of which leads to impaired consciousness.
The victim may experience short-term overexcitation, then drowsiness, convulsions and coma.

The cause of death in case of an overdose of Aspirin is most often kidney and liver failure and paralysis of the nerve centers of the brain responsible for respiratory and cardiac activity.

lethal dose of aspirin

It is clear that high doses of acetylsalicylic acid have a toxic effect on the human body, but is it possible to die from an overdose of this medicine? How many tablets make up a lethal dose of the drug? Such questions are most often of interest to parents whose child accidentally found a package of medicine and ate all of its contents. The severity of poisoning depends not only on the amount of the drug taken, but also on the general condition of the victim in the anamnesis, and on the timeliness of the therapeutic measures taken, and on the body weight of the person. Of course, it is much more difficult for children to cope with high doses of Aspirin.

Given that the mass of one small tablet of Aspirin is 0.25 g, it is easy to calculate that for a patient weighing 15 kg, taking 30 small tablets or 15 tablets weighing 0.5 g at a time will be fatal.

What to do with an overdose

If Aspirin poisoning does occur, the poisoned person needs to call an ambulance. Before the arrival of doctors, you should try to induce vomiting in the victim in order to prevent the spread of the toxic dose to the internal organs. After that, it is advisable to give the patient several tablets of activated charcoal (Aspirin does not have a specific antidote).

The best assistance to the patient can be provided in a hospital, where the following procedures can await him:

gastric lavage;
carrying out forced diuresis with drip injection of solutions and diuretics;
restoration of water and electrolyte balance;
symptomatic therapy, the introduction of cardiac drugs;
in severe forms of poisoning, hemodialysis may be prescribed.

With timely treatment, the well-being of a patient affected by Aspirin intoxication is restored over time.

What are the consequences of poisoning

As already mentioned, the success of the treatment of an overdose of acetylsalicylic acid depends on the severity of the poisoning, the speed of the measures taken and the general condition of the victim.

As a rule, acute poisoning of mild severity passes with little or no consequences for the health of the poisoned person. In mild forms of overdose, the risk of multiple organ failure is extremely small.

Severe and chronic forms of poisoning can lead to such serious consequences as toxic encephalopathy, peptic ulcer, kidney or liver failure, bronchial asthma. Such conditions lead to disability of the patient.

How to avoid an overdose

Preventive measures to prevent an overdose of Aspirin are reduced to the observance of simple rules for the storage and use of this drug.

Take acetylsalicylic acid only as prescribed by your doctor and in strictly recommended doses, especially when it comes to long-term use of the drug.
Keep the medicine package out of the reach of children and in the temperature conditions recommended by the annotation.
If you need to take other medications at the same time, be sure to consult your doctor.
Notify your doctor if you experience any side effects.
Do not take the medicine after the expiration date and do not purchase Aspirin at questionable pharmacies, so as not to be poisoned by a counterfeit.
Do not drink alcoholic beverages while taking acetylsalicylic acid.

Compliance with the above rules applies not only to the conditions of storage and use of Aspirin. The effectiveness of any drug can be reduced to zero if used improperly. And the abuse of drugs in general can turn them into poison. Therefore, in each home, a home first-aid kit should be assigned a certain place that is not accessible to children, and taking any medication should begin with a doctor's consultation and a careful study of the instructions for use.

vseotravleniya.ru

What happens if you overdose on aspirin?

Aspirin (or acetylsalicylic acid (ASA)) is a drug that exhibits antipyretic, analgesic, anti-inflammatory and antiplatelet effects. Included in the pharmacological group of non-steroidal anti-inflammatory drugs, which are derivatives of salicylic acid. Differs in availability, low cost and efficiency. That is why Aspirin can be found in any home pharmacy.

Despite all the benefits and assistance provided, Aspirin can be harmful if you exceed its recommended dosage. Let us consider in more detail when an overdose can occur, how to identify it and how to help the poisoned person in a similar situation.

Aspirin is known for its ability to thin the blood and affect blood clotting. Therefore, it is extremely important to follow the dosage indicated in the instructions. An overdose of acetylsalicylic acid can cause internal bleeding.

Features of the dosage of the drug:

a single (single) dose for an adult (and children over 15 years old) varies from 40 mg to 1 g;
the daily norm is 150 mg - 8 g;
multiplicity of reception - 2-6 times during the day;
the maximum duration of the course of therapy is 10 days.

Peculiarities of dosage in childhood:

for babies aged 2-3 years - a maximum of 100 mg within 24 hours;
for children from 4 to 6 years - a maximum of 200 mg;
for children aged 7 and older, the maximum dosage is 300 mg per day.

When does an overdose occur?

An overdose of Aspirin occurs when the maximum allowable dosage is exceeded. The instructions indicate that the first signs of poisoning may appear with a single dose of more than 150-300 mg of the drug for each kg of weight.

There are 3 degrees of severity of overdose:

moderate - when taking 150-300 mg of the drug for each kg of a person's weight;
significant - when taking 300-500 mg / kg;
potentially fatal when taken at 500 mg/kg or more.

Important! The lethal dose of Aspirin is individual for each individual person, much depends on the characteristics and condition of the body. Experts say that death can occur when taking more than 30 g of acetylsalicylic acid, these are 60 tablets of 500 mg. For children, a dose of more than 10 g may be critical.

Causes and forms of poisoning

Aspirin poisoning can occur for the following reasons:

the dose prescribed by the doctor is exceeded;
the drug was taken in combination with alcohol, anticoagulants or drugs;
the pills were expired or counterfeit;
self-treatment without medical supervision;
long-term use of aspirin in high doses;
suicide attempt;
the use of the drug by people for whom it is contraindicated. For example, those suffering from chronic pathology of the liver or kidneys.

Depending on the cause of intoxication, there are 2 forms of Aspirin poisoning:

acute overdose;
chronic overdose.

The acute form develops with a single use of a large number of acetylsalicylic acid tablets. In such cases, the concentration of the active ingredient in the blood varies within 300 μg / l and above. In this case, acute poisoning has 3 degrees of severity: mild, moderate and severe.

The chronic form of an overdose occurs with prolonged use of Aspirin in large quantities. It can develop even with a slight increase in the daily norm. The concentration of acid in the blood in this case can be equal to 150-300 mcg / l.

Each of these forms of poisoning manifests itself in different ways, the clinical picture of the patient's condition will be different. Therefore, we consider the symptoms of chronic and acute overdose separately.

Symptoms of a chronic form of poisoning

Diagnosing chronic intoxication with Aspirin is quite difficult, since its symptoms are similar to the symptoms of many diseases. It occurs after a long-term use of the drug, and it is difficult to immediately establish a diagnosis. In such cases, a blood test is performed to determine the content of acetylsalicylic acid in it. Most often, chronic overdose occurs in the elderly.

Symptoms of the chronic form of poisoning are:

hearing loss or deafness;
sensation of noise or ringing in the ears;
dyspnea;
agitation or hyperactivity;
slurred speech;
disruption of the digestive system;
pain in the abdomen;
feeling of nausea and vomiting;
increased sweating;
headache;
low levels of hemoglobin, leukocytes and platelets in the blood;
loss of consciousness.

Symptoms may develop slowly, with little intensity. Therefore, it is important to monitor changes in the body and, if intoxication is suspected, immediately consult a doctor.

Symptoms of an acute form of poisoning

Signs of acute intoxication with Aspirin appear 3-7 hours after taking the drug in excess dosage. At the same time, their severity and severity may differ depending on the severity of the poisoning: mild, moderate or severe.

With a mild degree of severity, the same symptoms develop as with a chronic overdose, but the consciousness of the victim will not be disturbed.

With an average degree of poisoning with acetylsalicylic acid, the following symptoms are observed:

violation of respiratory function (breathing quickens and becomes difficult);
the appearance of a cough with sputum;
increase in body temperature;
dysfunction of the liver and kidneys.

With a severe degree of overdose, symptoms such as:

pulmonary edema;
lack of oxygen;
rapid breathing;
blanching (or blue) of the skin;
body temperature rises significantly;
the pulse is quickened;
blood pressure is reduced;
agitation (for a short period of time);
hearing loss;
convulsions;
loss of consciousness;
in some cases, the amount of urine decreases.

If there is foam from the mouth, then the situation is critical and it is almost impossible to help the patient.

First aid

When an overdose of Aspirin is detected, it is important to properly provide emergency care to the victim. In this case, it is necessary to follow a certain sequence.

First aid measures include:

Call for an ambulance.
Gastric lavage. To carry out such a cleansing procedure, it is necessary to give the victim to drink about one and a half liters of liquid. It is best to use slightly warm boiled water. Then they induce vomiting by slightly pressing on the very root of the tongue. The procedure can be repeated if necessary. It is important that the fluid coming out of the stomach is clear. At the same time, washing is effective if no more than 1-2 hours have passed after taking the tablets.
Reception of an enterosorbent. These drugs help to remove all toxic compounds, poisons and accumulated toxins from the digestive tract. In addition, they are completely safe, as they are not absorbed into the bloodstream. You can choose any sorbent that is stored at home: Enterosgel, Polysorb, Activated carbon, Smekta, Laktofiltrum or Polyphepan.
Taking a salty laxative. For example, magnesium sulfate.
Soldering the patient with clean water. But you can not immediately drink a lot of liquid. It is best to drink 2-3 tablespoons (water, decoction of dried fruits) every 10 minutes.
If the victim is unconscious, it is necessary to monitor his breathing and provide him with free access to fresh air. If necessary, when a person stops breathing, artificial respiration should be performed.

Features of inpatient treatment

After providing emergency care, the patient is taken to the hospital. Treatment in a hospital is usually carried out according to the following scheme:

Solutions are administered intravenously to activate the excretion of drug residues by the kidneys. For example, Furosemide.
Diuretics are prescribed.
Restore the ionic and water balance of the blood using sodium bicarbonate solution.
In case of bleeding, the deficiency of blood volume is replenished using Reopoliglyukin or Hemodez.
Benzodiazepines are used for convulsions.
If necessary, they can prescribe heart drugs, hepatoprotectors or oxygen therapy.

Further treatment is symptomatic.

Possible consequences

After an overdose of Aspirin, effects such as:

disruption of the kidneys of aphids of the liver;
toxic hepatitis;
pulmonary edema;
the formation of ulcerative defects on the surface of the stomach or duodenum;
various internal bleeding;
coma;
fatal outcome.

With mild to moderate severity of poisoning, such serious consequences are likely to be avoided. Much in such cases will depend on the timely provision of first aid.

An overdose of Aspirin is a dangerous condition that threatens the health and life of a person. It is important to study the information and understand what will happen as a result of taking the drug in large doses. This knowledge will help you avoid poisoning and negative consequences. Stick to the recommended dosage and do not self-medicate!

poisoning.info

Aspirin - overdose: symptoms and consequences of acetylsalicylic acid poisoning, a lethal dose of the drug

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Aspirin is a member of the group of non-steroidal anti-inflammatory drugs. It has many indications (inflammatory pathologies, a tendency to thrombosis, hyperthermia, diseases of the heart, blood vessels and joints, and others) and contraindications.

During treatment with this drug, the dosage must be strictly observed. Otherwise, if it is exceeded, acute or chronic poisoning may develop.

In this article, you will learn what will happen if you drink a lot of acetylsalicylic acid tablets, what effect aspirin has in case of poisoning, what are the symptoms and consequences of an overdose of the drug, and you will also learn how to provide first aid to the patient in this case.

Reasons for an overdose

Any person should know the reasons why acetylsalicylic acid poisoning develops:

To avoid poisoning, it is necessary to correctly calculate the dose of the drug.

The dosage is calculated depending on the weight of the patient. Adults and children over 15 years of age take 40 milligrams per 1 kilogram of body weight. This is a single dose.

The daily dose of aspirin should not exceed 3 grams, that is, 6 Aspirin tablets. In this case, an interval between doses of at least 4 hours should be observed.

Symptoms of acute and chronic overdose

An overdose of acetylsalicylic acid can be acute and chronic. It depends on the time of exposure and the dose of the drug.

Acute form of poisoning

Acute overdose occurs due to a single dose of an increased dose of the drug (more than 300 milligrams). The clinical picture develops a few hours after taking Aspirin. Pathological signs depend on the severity of the poisoning.

An overdose of aspirin in a mild form (the concentration of the drug in the blood is 300 milligrams) is marked by the following signs:

Hearing loss, tinnitus;
Nausea;
Single vomiting;
Headache and dizziness;
Abdominal pain;
increased sweating;
Euphoria, emotional overexcitation.

Moderate intoxication (the concentration of the active substance in the blood is from 350 to 500 milligrams) of severity is manifested by a number of pathological symptoms:

Dyspnea. The patient notes difficulty and increased breathing;
Cough with mucous sputum;
General hyperthermia (increased body temperature);
The heart rate changes. Tachycardia or bradycardia may occur;
Bleeding open and closed. Bleeding can occur in the digestive tract, urinary tract, from the nose, gums, and so on.

In severe overdose, confusion, severe respiratory failure in the form of pulmonary edema, loss of consciousness and coma are noted.

Chronic overdose

This type of intoxication occurs when the patient exceeds the dosage for a long time. The clinical picture is similar to an acute form of poisoning.

However, it should be remembered that the symptoms develop rather slowly, and the intensity of their manifestation is weak:

Gradual loss of vision and hearing;
Episodic abdominal pain, dyspepsia;
Cardiopalmus;
Unreasonable increase in body temperature;
Emotional arousal or, on the contrary, stupor;
Respiratory failure in the form of shortness of breath.

Reye's syndrome

Reye's syndrome is a complication of acute intoxication. This condition is typical for children.

The main signs of the syndrome:

The age of the child is under 12;
Decreased blood pressure;
repeated vomiting;
Dyspnea;
Bleeding and hemorrhage.

This is a life-threatening complication. Due to severe intoxication and bleeding, the child may die.

First aid for drug overdose

It should be noted right away that there is no antidote for Aspirin. Help is symptomatic.

If signs of an overdose are found, then it is necessary to provide the following assistance to the victim:

Call the ambulance team. Before the arrival of medical workers, it is necessary to provide assistance on their own and be with the patient, without leaving him alone;
If the drug was taken less than 60 minutes ago, it is advisable to perform a gastric lavage. However, it must be remembered that washing is carried out only when the patient is conscious. A person must be allowed to drink 1.5 liters of clean water without gas. Then induce vomiting (press on the root of the tongue);
Give magnesium sulfate to drink. This is a saline laxative that will help remove toxins from the body;

Absorbents must be taken. They are able to bind toxins and remove them from the body. These drugs include Activated carbon, Enterosgel, Laktofiltrum. The dosage of activated carbon should be calculated depending on the weight. For 10 kilograms of body weight, you need to take 1 tablet;
If the patient is unconscious, then you need to determine the pulse and respiration. If vital functions are preserved, then let ammonia breathe. Place the patient in a lateral position to avoid suffocation. Control breathing and pulse until the arrival of doctors;
If breathing and pulse are absent, then it is necessary to immediately begin to perform resuscitation measures: chest compressions and artificial respiration.

The ambulance team evaluates the patient's condition and transports him to the hospital. At the same time, infusion therapy is carried out with physiological saline, Polyglucin, Reopoliglyukin. Symptomatic treatment is carried out in the hospital.

Questions about Aspirin

This drug is familiar to everyone, in connection with this, a lot of questions arise. It is necessary to consider in detail the most important of them.

When to See a Doctor

Indications for seeking medical help are the following conditions:

It is imperative to consult a doctor if a child, an elderly person or a pregnant woman has been poisoned.

Lethal dose

A high dose of Aspirin has a toxic effect on the body. However, not many people know that this commonly available drug can kill a person.

The lethal dose of aspirin is the amount of the drug, under the influence of which pathological changes occur in the body that are incompatible with life.

If a patient takes Aspirin at a dose above 500 milligrams per 1 kilogram of body weight, then severe intoxication with a fatal outcome will develop. In this case, it is almost impossible to save a person.

Aspirin and alcohol

Can Aspirin be combined with alcohol? This question can be answered unequivocally - no.

Consequences of combining aspirin with alcohol:

Changes in the blood. Aspirin thins the blood, and alcohol, on the contrary, provokes its thickening. In combination, they can provoke massive hemorrhages in various organs. If a brain hemorrhage occurs, the person may die;
Pathological effects on the stomach. This mixture irritates the gastric mucosa, which leads to inflammation, erosions and ulcers. If a person has a peptic ulcer, then the likelihood of gastric bleeding is high;
Liver damage. Alcohol and Aspirin break down in the liver, and their mixture leads to the destruction of its cells and the development of hepatitis and cirrhosis.

Consequences of an overdose of aspirin

The consequences of intoxication depend on the state of the patient's body and the severity of the poisoning.

A mild overdose with timely assistance and treatment to a doctor can end safely.

Aspirin poisoning with moderate and severe intoxication has quite serious consequences:

In severe cases, the patient is expected to die.

This article is often read... Overdose Nurofen overdose in adults and children Overdose Overdose of insulin-containing drugs

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Aspirin overdose: symptoms, what to do, consequences

Aspirin is widely known for its ability to reduce elevated body temperature and thin the blood. It is one of the main components of home first aid kits. For many patients, this drug helps to improve their health.

But can acetylsalicylic acid be dangerous? Moreover, is it possible to get poisoned by aspirin? If this happens, then how to see intoxication, what kind of help will be needed? How to treat an overdose, are there any consequences? How does acetylsalicylic acid act on the body? There are many questions that need to be dealt with.

The effect of aspirin on the body

Aspirin has many analogues, but all of them are made on the basis of acetylsalicylic acid. This drug belongs to non-steroidal anti-inflammatory drugs and antiplatelet agents. It relieves pain, inflammation, has an antipyretic effect. By reducing platelet aggregation, the drug prevents the formation of blood clots.

Aspirin is completely absorbed in the digestive tract. Its breakdown occurs in the liver, and excretion occurs through the kidneys. Aspirin is used for acute colds accompanied by fever, migraine, pain from inflammation, in order to prevent cardiovascular complications in people with atherosclerosis, coronary heart disease, cerebrovascular accident and other cardiovascular diseases.

Causes of aspirin poisoning

Like any drug in high doses, aspirin can be poisonous. The reasons for an overdose of aspirin are as follows.

Treatment without a doctor's prescription, when taken at the wrong dose or without taking into account contraindications.
Intentional excess of the therapeutic dosage (very rare).
When taken correctly in case of significant impairment of liver and (or) kidney function.
When a child finds a package of medicine.

Aspirin poisoning can be acute or chronic.

A single intake of a large dose for two days leads to the development of acute intoxication. In this case, the concentration of acetylsalicylic acid in the blood will exceed 300 μg / l.

If the maximum daily dose was exceeded for a long time, chronic poisoning develops. The content of the drug in the blood in this case is 150-300 mcg / l.

The maximum daily intake of the drug is 3 grams. For aspirin poisoning to occur, you need to drink 100 mg per 1 kg of body weight per day. A lethal dose of 500 or more mg / kg per day.

Symptoms of chronic aspirin overdose

Chronic intoxication is difficult to diagnose. Usually, relatives can tell for sure when they find the packaging of a recently purchased drug is empty. The most reliable diagnostic method is the determination of the content of acetylsalicylic acid in the blood. More often, chronic intoxication occurs in older people.

In chronic overdose of aspirin, the symptoms will be as follows:

noise in ears;
indigestion;
stomach ache;
hearing loss;
nausea, vomiting;
sweating;
headache;
anemia, a decrease in the level of leukocytes and blood platelets;
stupor, loss of consciousness.

Chronic intoxication is dangerous by provoking bleeding, the development of drug-induced bronchial asthma. Prolonged overdose may exacerbate heart failure.

Symptoms of acute aspirin poisoning

Acute poisoning has 3 degrees of severity. With a mild one, the symptoms will be the same as with chronic intoxication, only consciousness in this case will not be disturbed.

An overdose of moderate severity is manifested by increased frequency and difficulty in breathing, a cough with mucous sputum appears, and body temperature begins to rise. The toxic effect is directed to the nervous system, lungs, kidneys, liver, blood.

A severe overdose of acetylsalicylic acid causes respiratory failure in victims with a transition to pulmonary edema. It is accompanied by an even greater increase in breathing, coughing, blanching of the skin, followed by blue. When there is foam at the mouth, at this stage of pulmonary edema, rarely anyone can be saved.

Body temperature reaches high levels. Blood pressure gradually decreases, the pulse is quickened, patients feel interruptions in the work of the heart. Before the loss of consciousness, which develops gradually, there is a short period of excitement. First appear drowsiness, stupor. Then the victim falls into a coma. Seizures develop.

With kidney damage, urination decreases. A life-threatening electrolyte imbalance develops. The content of sodium in plasma increases, and potassium decreases.

Poisoning is characterized by the development of toxic encephalopathy (brain disease). In mild cases, it is manifested by general weakness, scattered attention, irritability, poor sleep, slowness, apathy, and anxiety. With further progression, consciousness is disturbed.

An aspirin overdose ends in death from acute liver or kidney failure, pulmonary edema, paralysis of the centers of the brain that control breathing and cardiac activity.

First aid and further treatment

If you notice signs of an aspirin overdose, what can you do? If there is a suspicion of poisoning, you should immediately consult a doctor. While the ambulance is on the way, the patient should try to induce vomiting, and then give activated charcoal. In the future, the reception of sorbents continues for several more days. In severe aspirin poisoning, the victim should be taken to a hospital as soon as possible.

In the clinic, the stomach is washed, forced diuresis is carried out, which involves the intravenous drip of solutions, and then diuretics. The treatment also includes correction of the ionic and water balance of the blood. If necessary, cardiac agents are introduced, symptomatic treatment is carried out. Hemodialysis is also prescribed if there is severe poisoning with acetylsalicylic acid.

Consequences of an aspirin overdose

The recovery of the body largely depends on the severity of the poisoning, the type of its course, the timeliness of medical care, and the previous state of the body. In an acute course of mild to moderate severity, poisoning can pass without a trace. The likelihood of developing multiple organ failure is very low. In a severe form or chronic overdose of aspirin, the consequences can be significant. There is a high risk of toxic encephalopathy, the development of renal and hepatic insufficiency, bronchial asthma, and peptic ulcer disease.

So, we managed to find out that uncontrolled intake of aspirin creates a danger of poisoning. Penetrating into all organs, it can cause multiple insufficiency, which is dangerous not only for health, but also for life. Symptoms of poisoning, especially chronic, are nonspecific. Therefore, if chronic intoxication develops in an elderly person, then the clinical manifestations of poisoning can be taken as signs of chronic diseases and not paid due attention to them. After all, tinnitus, headaches, hearing loss, nausea suffers from many older people who do not take aspirin. First aid for intoxication has no features and is based on the general principles of the treatment of poisoning. There is no specific antidote for aspirin. Therefore, in order to avoid such situations, all medicines should be taken only as directed by a doctor!

What can a child eat after poisoning and vomiting

Acetylsalicylic acid is widely used by people all over the world, but few people know how an overdose of this drug manifests itself, what are its harms and benefits.

Any drug, if used incorrectly, can lead to unpleasant consequences for the body. It is not necessary to intentionally poison yourself with drugs in order to get a side effect - often an overdose occurs in people who hope for a speedy recovery.

It is important to remember that any medication must be used with caution, and special attention should be paid to the dosage when treating children and people suffering from chronic diseases.

Acetylsalicylic acid, popularly known as Aspirin, is able to have an effective effect on the body, lowering body temperature to normal and thinning the blood. This drug is an important element of any first aid kit - almost any ordinary person has it at home, in the car of every motorist, and you can buy it at a pharmacy for little money.

Nevertheless, acetylsalicylic acid poisoning is a fairly common phenomenon, and this is due, first of all, to the incorrect use of the drug and incorrect dosage calculation.

Action

Based on Acetylsalicylic acid, a huge number of drugs are produced, but the active substance is always the main component. The drug is non-steroidal in nature, copes well with inflammation. Among its useful features is the ability to significantly reduce pain, get rid of heat. Moreover, it is Aspirin and its analogues that prevent the formation of life-threatening blood clots in the body.

The acid is completely absorbed by the digestive organs, dissolution here occurs at the highest possible level. The breakdown of the substance occurs in the liver, and the results of the breakdown are excreted through the human kidneys. The range of application of this drug is quite wide - it is the main method of treatment for colds, for the prevention of cardiovascular disorders and even circulatory disorders of the brain.

Poisoning

Like poisoning with other medications, an overdose of acetylene carries a serious health hazard. The reasons for such an overdose of the drug may be as follows:

The use of the drug occurs without the testimony of a doctor. In this case, the medicine does not always have a positive effect, and in some situations even acts negatively.
The patient deliberately increases the dosage of the drug. This phenomenon is quite rare and is often associated with a desire to quickly get rid of the symptoms of the disease.
Problems may arise in patients who have impaired liver and kidney function. In this case, therapy is quite dangerous.
At risk are small children who have access to the first aid kit. In this case, it is recommended to act immediately - the child needs to wash the stomach, first call an ambulance.

Poisoning with this drug can be both acute and chronic. Acute intoxication occurs when the patient has taken a large dose of the drug at a time. Prolonged excess of the allowable amount of the drug leads to a chronic form of poisoning and poses a serious danger to human health.

Note! The maximum dose of the drug allowed for daily intake is three grams. The lethal dose is 500 or more milligrams per kilogram of body weight per day.

Symptoms of the chronic form

Acetylsalicylic acid, an overdose of which has occurred for a long time, causes severe harm to health. No matter how many days the body was poisoned, it is quite difficult to diagnose this problem even in a medical institution.

Usually, the diagnosis is based on the testimony of the patient's relatives, who know exactly when the medicine was purchased and how many tablets are left in the package. A blood test is also performed, only it can show an increased content of a substance in the blood. Based on these data, appropriate treatment is prescribed.

Chronic overdose of acetylene can cause the following symptoms:

noise or ringing in the ears;
problems of the digestive system;
discomfort in the abdomen;
decrease in auditory functions;
feeling of nausea, vomiting;
increased sweating;
headache;
complete or partial loss of consciousness.

An overdose can also cause bleeding and other unpleasant symptoms, which will be a serious hindrance to therapy.

Symptoms of acute intoxication

Acute poisoning with this drug involves three degrees of severity at once. The mildest form involves the same symptoms as in the case of chronic poisoning with the drug, only the consciousness will be active in this case.

The average severity of an overdose with this drug component suggests breathing difficulties, a pronounced wet cough and an increase in overall body temperature. At the same time, such important organs as the lungs, liver, kidneys and nervous system suffer from intoxication.

The most difficult side effect is a severe overdose of Acetylsalicylic acid. The substance causes severe respiratory failure, which affects natural life.

This symptom develops into pulmonary edema, due to which breathing difficulties are only exacerbated. The skin of the poisoned person becomes very pale, the cough intensifies. The final stage is the appearance of foam from the mouth, and this symptom indicates an approaching death.

Note! Severe overdose of habitual Aspirin in most cases leads to death. Even a timely call to doctors is unlikely to help save a patient's life.

In addition to the listed dangerous symptoms, other characteristic signs are observed in severe poisoning:

Significant increase in body temperature.
Lowering blood pressure to the lowest levels.
The pulse quickens.
There are noticeable interruptions in the work of the heart.
Then there is a short period of excitement, after which consciousness is turned off.
There is a convulsive state, after which the patient falls into a coma.

First aid

If one of your loved ones or those around you has been poisoned by a drug, it is imperative to call an ambulance and immediately begin to take actions that alleviate the symptoms of intoxication.

The patient needs to induce vomiting, a weak solution of potassium permanganate will be an excellent assistant in this. Then you need to give the victim activated charcoal. After removing the primary symptoms of poisoning, the intake of absorbents should not be stopped, it is important to restore the balance of substances in the body and provide the patient with plenty of fluids.

A severe form of poisoning requires immediate hospitalization. Doctors will make a mandatory gastric lavage, restore the balance of substances in the body. In addition, solutions are administered intravenously to the victim, eliminating toxic substances and normalizing the condition. Other methods of treatment are prescribed by a specialist after a detailed examination of the patient and obtaining the results of the tests.

Video: Aspirin and Paracetamol.

Effects

As with any poisoning, acetylsalicylic acid intoxication involves subsequent treatment. It will continue depending on the severity of damage to the body, only the attending physician can prescribe therapy.

Note! In no case is it recommended for the patient to take medications without a doctor's prescription, otherwise repeated intoxication of the body is likely.

Mild and moderate forms of poisoning may well do without consequences, but a severe form poses a serious danger to the further life of a person. The victim may develop encephalopathy, acute liver or kidney failure, bronchial asthma, and even an ulcer. Treatment in this case is carried out exclusively under the supervision of a professional who draws conclusions based on examination and analysis.

Despite the apparent safety of the drug, it can pose a serious threat to health. Therefore, it is important to use the medicine only after the recommendation of a doctor, strictly observe the dosage and hide medicines from children.

An overdose is likely with the following factors:

Self-treatment without taking into account possible contraindications.
Suicide attempt.
Treatment against the background of liver diseases.
The use of tablets by a small child as a result of carelessness of parents.
Joint reception with alcohol.

An overdose of acetylsalicylic acid may occur in the following situations:

The child accidentally found the package and ate the pills.
Suicide.
Proper intake against the background of pathologies of the liver, kidneys.
Exceeding the dosage, non-compliance with the instructions for use of the drug.

A therapeutic, not exceeded dose of ASA can cause poisoning when:

the use of the drug along with alcoholic beverages;
the use of expired tablets;
taking aspirin with heparin;
medication, despite the presence of contraindications to it.

How many ASA tablets can provoke an overdose and subsequent poisoning? A single dose of an overdose can cause very acute intoxication. In this case, the concentration of acid in the patient's blood will show a figure of more than 300 mcg / l. In the case of prolonged use of excessive doses, chronic poisoning with this medication may develop. In this situation, the level of acetylsalicylic acid in the blood will be about 150-300 mcg / l.

The maximum allowable daily dose is three grams (six tablets of 0.5 g). A dose of about 100 milligrams per kilogram of the human body per day will already lead to poisoning. As for the lethal dose of Aspirin, it is 500 or more mg / kg per day. In the event of an overdose of Aspirin, the consequences can be horrendous, even fatal.

Like any drug, acetylsalicylic acid, taken in high dosage, can have not only a detrimental effect on the body, but also cause death. Aspirin overdose occurs for several reasons:

Accidental use of a large number of pills (usually by children)
Uncontrolled independent use without taking into account contraindications
Too long use
Exceeding the recommended amount of aspirin in order to accelerate (strengthen) the therapeutic effect
Renal or liver failure (in this case, taking even the recommended amount of the drug may cause an overdose)
Simultaneous administration of several drugs with salicylates.

Depending on the intake of tablets, an overdose can be acute and chronic. In the first case, intoxication develops after a single dose of large doses of the drug, or if the dose exceeded 100 mg per kilogram of body weight for more than 2 days. Chronic overdose develops as a result of long-term use of aspirin, exceeding the daily allowance.

In order to prevent an overdose, it must be remembered that no more than 3-4 g of acetylsalicylic acid per day can be taken without health consequences. The maximum amount for a single dose is 300-1000 mg. A lethal dose of aspirin for an adult is more than 500 mg per 1 kg of body weight.

Clinical picture of aspirin poisoning

In case of poisoning, it is important to provide first aid to the victim in time, for this it is necessary to recognize the symptoms. Acute and chronic intoxication with Aspirin is possible.

With chronic intoxication, it is very difficult to make a quick diagnosis. An accurate diagnostic method is to determine the level of acetylsalicylic acid in human blood. Basically, the chronic form of poisoning is fixed in old age.

Symptoms of chronic intoxication with Aspirin:

stomach ache;
the presence of noise in the ears;
severe and painful nausea;
vomit;
indigestion;
hearing loss;
headache;
increased sweating;
dyspnea;
increased heart rate with mild exertion or at rest;
fainting;
stupor.

The main danger of chronic poisoning is that there is a risk of bleeding, the development of bronchial asthma. It is important to remember that prolonged overdose is fraught with increased heart failure.

Signs of acute overdose of ASA

Symptoms of an acute aspirin overdose appear 3-8 hours after taking an excessively high dose of the drug. There are three main degrees of severity of poisoning.

The mild form is characterized by the same clinical picture as chronic intoxication. However, there may be a disturbance of consciousness.
With a moderate overdose, shortness of breath and palpitations, cough with sputum and mucus, fever can be noted. As for the toxic effects, it is directed to the liver and kidneys, blood, lungs and nervous system. The rhythm of heart contractions is disturbed, the development of bleeding of various localization is possible.
In severe overdose, pulmonary edema and paralysis of the respiratory system occur, which can be fatal. Patients have a strong cough, pallor and blueness of the skin. If foam appears in the oral cavity, then the chances of salvation are very scanty. The body temperature rises, blood pressure decreases, the pulse quickens and there are interruptions in the work of the heart. Stupefaction, drowsiness and fainting, convulsions and coma appear. If there is kidney damage, then the portion of urine separated is noticeably reduced.

A rare but extremely serious complication of acute ASA overdose is Reye's syndrome. It is characterized by the sudden appearance of indomitable vomiting, depression of consciousness. The pressure drops sharply, breathing and cardiac activity are disturbed. Intravascular coagulation develops. In most cases, this condition ends in death.

Aspirin overdose: symptoms, what to do, consequences

Possible acute and chronic poisoning:

In the first case, the patient's blood contains more than 300 mg / liter.
In the second, 150-300 mg / l is enough.

Acute

Clinical picture:

Severe nausea leads to vomiting.
A person experiences euphoria, movement and speech are active.
Headache and dizziness appear.
There is noise in the ear passages, ringing, vision and hearing are reduced.
The temperature rises.
Breathing quickens, shortness of breath develops.
Possible bradycardia or tachycardia.
Seizures are observed.
There are local bleeding - subcutaneous, nasal. Clots can be found in stool and urine.
If first aid is not provided, coma and death are likely.

Chronic

Main features:

Hearing loss.
Dyspepsia.
At rest, tachycardia.
Periodic temperature increase outside the presence of inflammatory processes.
States of excitation and inhibition.
Possible slurred speech.

Reye's syndrome

The main symptoms of poisoning:

Repeated and indomitable vomiting on the background of neurological problems.
Oppression of consciousness and coma.
Violations of the heart rhythm, breathing.
Arterial hypotension.
Thrombohemorrhagic syndrome.

Lethal dose

Depending on the state of the person, age, the presence of chronic diseases, the amount of the drug varies:

Moderate option - 150-300 mg / kg.
Pronounced - 300-500 mg / kg.
Lethal - more than 500 mg / kg.

1 tablet of Aspirin contains 0.25 g or 0.5 g of the active substance. Therefore, an overdose resulting from a single dose of 30 small pieces or 15 large ones is considered potentially dangerous for a child weighing 15 kg.

Although such a harmless medicine can be poisoned. With a significant excess of the recommended doses and with prolonged use of the drug, an overdose of Aspirin may occur. Without detracting from the usefulness of this drug, let's not forget that everything is good in moderation. How can an overdose occur?

How does aspirin affect the human body?

Aspirin belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), the action of which is based on the properties of acetylsalicylic acid.

These properties are manifested by analgesic, antipyretic and, of course, anti-inflammatory effects.
Thanks to Aspirin, platelet aggregation in the blood decreases, preventing the formation of their clusters - blood clots. That is why Aspirin is almost always prescribed to people suffering from cerebrovascular accidents, angina pectoris and other pathologies of the cardiovascular system.
In addition, it is prescribed to patients diagnosed with atherosclerosis in order to prevent complications from the heart.
Finally, Aspirin is most often used in the treatment of acute respiratory viral infections with high body temperature, with various pain syndromes, and migraines.

Why you can get poisoned by aspirin

with self-treatment with a drug that does not take into account the dosage, contraindications and other recommendations prescribed in the instructions for use;
if a small child found a package lying unattended and ate pills;
rarely - with the intentional taking of large doses of the drug in order to accelerate the therapeutic effect or for another purpose;
with a significant violation of the activity of the kidneys or liver, which the person taking Aspirin might not know about.

Depending on the amount of medication taken and the duration of exposure, aspirin poisoning can be acute or chronic.

Clinical picture of chronic poisoning

headache;
nausea, vomiting;
increased sweating;
hearing loss, "stupor";
pain in the stomach;
indigestion;
tinnitus;
anemia, a decrease in the level of platelets and leukocytes in the blood;
loss of consciousness.

Chronic overdose can cause drug-induced asthma and bleeding, and prolonged overdose can increase symptoms of heart failure and other dangerous consequences. The level of Aspirin in the blood plasma in chronic poisoning ranges from 150 to 300 mcg / l.

Signs of acute aspirin intoxication

With a single intake of high doses of Aspirin in the human body, acute poisoning occurs. Depending on the strength of the toxic effect, it can be of three degrees of severity.

During treatment with this drug, the dosage must be strictly observed. Otherwise, if it is exceeded, acute or chronic poisoning may develop.

Reasons for an overdose

To avoid poisoning, it is necessary to correctly calculate the dose of the drug.

The dosage is calculated depending on the weight of the patient. Adults and children over 15 years of age take 40 milligrams per 1 kilogram of body weight. This is a single dose.

The daily dose of aspirin should not exceed 3 grams, that is, 6 Aspirin tablets. In this case, an interval between doses of at least 4 hours should be observed.

Symptoms of acute and chronic overdose

An overdose of acetylsalicylic acid can be acute and chronic. It depends on the time of exposure and the dose of the drug.

The effect of aspirin on the body

Aspirin is completely absorbed in the digestive tract. Its breakdown occurs in the liver, and excretion occurs through the kidneys. Aspirin is used for acute colds accompanied by fever, migraine, pain from inflammation, in order to prevent cardiovascular complications in people with atherosclerosis, coronary heart disease, cerebrovascular accident and other cardiovascular diseases.

Causes of aspirin poisoning

Like any drug in high doses, aspirin can be poisonous. The reasons for an overdose of aspirin are as follows.

Treatment without a doctor's prescription, when taken at the wrong dose or without taking into account contraindications.
Intentional excess of the therapeutic dosage (very rare).
When taken correctly in case of significant impairment of liver and (or) kidney function.
When a child finds a package of medicine.

Aspirin poisoning can be acute or chronic.

A single intake of a large dose for two days leads to the development of acute intoxication. In this case, the concentration of acetylsalicylic acid in the blood will exceed 300 μg / l.

If the maximum daily dose was exceeded for a long time, chronic poisoning develops. The content of the drug in the blood in this case is 150-300 mcg / l.

Diagnostics

If a patient with a suspected overdose of acetylsalicylic acid is admitted to the toxicology department, an examination is started immediately:

Find out from the persons accompanying the patient or the patient himself, what he took and in what quantity. If a person drank another drug or alcoholic drink at the same time as Aspirin, be sure to inform the doctor.
To determine the concentration of a substance, laboratory blood tests are prescribed, and special test strips are used to detect in the urine.
When damage to internal organs is expected, hardware methods are used.

Based on the results of the examination, the therapy program is adjusted.

Treatment Methods

The treatment regimen includes:

Forced diuresis with furosemide.
Alkalinization of the blood with sodium bicarbonate.
Elimination of bleeding with Dicinon or Etamzilat, with significant surgical intervention is likely.
Restoration of blood volume with a significant loss of gemodez, Reopoliglyukin.
Use of pressure chamber or oxygen cushion.
The introduction of hepatoprotectors - Karsil, Essentiale, Heptral.
The use of benzodiazepines in convulsions.

What will be the prognosis depends largely on the severity of the condition, the time of assistance. It must be remembered that a severe overdose is fatal.

Antidote

There is no specific antidote, but the use of general sorbents can treat intoxication.

Familiar tool properties

Aspirin belongs to the group of non-steroidal anti-inflammatory drugs. Its active substance is acetylsalicylic acid (or salicylic ester of acetic acid). The mechanism of its action is the irreversible suppression of platelet aggregation (possibility of gluing) and the neutralization of cyclooxygenase, an enzyme that promotes the formation of arachidonic acid, a substance responsible for the development of the inflammatory process.

Due to its ability to thin the blood, acetylsalicylic acid is actively used in preparations for the prevention of cardiovascular diseases, the prevention of heart attack and strokes. But the same property contributes to the occurrence and intensification of internal bleeding - depending on the dose of aspirin taken - by 50-100%. Moreover, the effect of the drug persists for 2 days after cancellation.

After ingestion, the active substance of aspirin is absorbed very quickly - a significant part of the small intestine, a smaller one - in its wall. After that, the active substance binds to blood proteins and spreads freely throughout the body. The highest level of concentration of the substance in the blood is reached five hours after taking the tablets on an empty stomach. If aspirin is taken with food, then its maximum values are recorded after 8 hours.

The drug is broken down by the liver and excreted by the kidneys. The duration of the process depends on the amount of the drug taken, the ability of liver enzymes to convert acetylsalicylic acid, and the condition of the kidneys. A healthy body copes with the withdrawal of small doses of acid in 2-3 hours, cleansing from a large amount of the drug takes about 15-30 hours.

Properties of Aspirin, indications for use

Aspirin has a huge number of analogues, but they are all made on the basis of acetylsalicylic acid. This drug is considered an anti-inflammatory non-steroidal agent, and also belongs to antiplatelet agents. It has antipyretic and analgesic properties, reduces blood clotting and prevents the development of inflammatory processes.

Despite this, exceeding the prescribed dosage, you can easily get poisoned. At the same time, the beneficial qualities of the drug turn into negative ones: inhibition of the blood coagulation system creates a risk of bleeding, ulceration of the gastrointestinal mucosa, especially the stomach.

ASA is absorbed in the gastrointestinal tract, excreted through the kidneys, and decay occurs in the liver.

Indications for the use of Aspirin:

increased body temperature;
migraine;
inflammatory processes with pain syndrome;
rheumatism, rheumatoid arthritis;
cardiovascular pathologies (myocarditis);
cardiac ischemia;
atherosclerosis;
prevention of myocardial infarction, thrombosis and embolism.

For pregnant women and nursing mothers, taking acetylsalicylic acid is possible only as directed by a doctor. Uncontrolled use of Aspirin by pregnant women can lead to anomalies in the development of the child, to a weakening of labor and other negative consequences. ASA easily passes into breast milk, so if a nursing mother takes an Aspirin tablet, the baby may develop stomach bleeding.

In pediatric practice, the use of Aspirin in children under 15 years of age is prohibited due to the risk of developing Reye's syndrome (encephalopathy, cerebral edema, liver damage).

The main indication for the use of acetylsalicylic acid is a pain syndrome of any origin (headache, toothache, muscle pain). Aspirin can even cope with pain in the joints, which are particularly drug resistant.

The second indication for the use of acetylsalicylic acid is an increase in body temperature in infectious diseases and other diseases. Aspirin allows you to quickly and gently lower the temperature.

Repeated use of aspirin tablets with persistent fever or persistent pain is not recommended due to a significant increase in the risk of side effects of the drug. In this case, the patient is advised to seek medical help. The consequences of an overdose of acetylsalicylic acid are very serious.

First aid for overdose

To remove Aspirin in case of poisoning, medical treatment is necessary. At home, before the arrival of the medical team, you can reduce the symptoms and risks of death by resorting to the following procedures:

Stop taking the drug.
The stomach is washed with 1–1.5 liters of a weak solution of potassium permanganate or warm water. If the overdose occurred more than an hour ago, the measure is ineffective.
They clean the food tract with sorbents - they use Activated carbon, Enterosgel, Laktofiltrum, Polysorb as an antidote.
Salt laxative - magnesium sulfate is recommended.

What can you do if you notice symptoms of poisoning? In case of suspicion, it is important to immediately consult a doctor. In the meantime, you need to wash the stomach and provoke vomiting, take activated charcoal, as it is great for any poisoning. You can give the victim a saline laxative (magnesium sulfate). If there is a severe degree of intoxication, it is important to urgently deliver the patient to the hospital, where he can be provided with qualified assistance.

In the hospital, the victim will be given a high-quality gastric lavage, forced diuresis, which means intravenous drip infusion of a solution, taking diuretics. If necessary, cardiac drugs are administered, symptomatic therapy and hemodialysis are carried out. Thus, if you suspect Aspirin intoxication, you can not self-medicate, it is important to urgently consult a doctor.

First aid for suspected intoxication with acetylsalicylic acid is to call an ambulance. Before the arrival of medical workers, try to induce vomiting, give the victim activated charcoal. Gastric lavage is carried out through a probe in the clinic or at home under the supervision of an emergency doctor.

The tactics of treatment depends on the degree of intoxication and the age of the patient. Mandatory hospitalization, regardless of the severity of the condition, is subject to the elderly, infants, children under 3 years of age, persons who deliberately took high doses of aspirin, if a chronic form of poisoning is suspected.

Therapy for intoxication with salicylates is carried out in 3 stages:

stopping the drug from entering the body;
forcing diuresis, hemodialysis is possible;
prevention and elimination of dehydration.

According to indications, cardiac preparations, symptomatic treatment agents are prescribed.

Standard patient management:

After gastric lavage, vaseline oil is injected through the probe.
After 1 hour - the introduction into the stomach of an anti-burn emulsion, 0.5 l of a solution of baking soda.
Taking diuretics orally or drip.
With the development of bleeding - hemostatic agents. Medicines "Vikasol", aminocaproic acid. Perhaps the appointment of a blood transfusion.
In severe intoxication - hemodialysis.

Patients are shown bed rest for 3 days.

Identification of symptoms of an overdose in a person is an indication for the start of first aid. In doing so, the following simple steps are performed:

It is necessary to thoroughly rinse the stomach until clean lavage water appears (see. Gastric lavage). This method allows you to remove excess acetylsalicylic acid from the body and prevent its further absorption. Washing is carried out in the following way: a person is given to drink 1-1.5 liters of clean water, after which they induce vomiting by pressing on the root of the tongue.
Reception of enterosorbents (Activated carbon, Enterosgel) must be carried out in the first hours after an overdose of acetylsalicylic acid. These drugs bind aspirin in the lumen of the stomach and intestines, disrupting its absorption and excretion from the body.
It is always necessary to seek medical attention in case of symptoms of poisoning.

These first aid measures are very simple and can be performed by the victim himself. After their provision and hospitalization of the patient, special medical care is already provided using intravenous infusions, increased diuresis, dialysis.

What happens with an overdose of acetylsalicylic acid? A person develops symptoms of acute or chronic poisoning, which pose a serious health hazard. In this regard, it is necessary to control the intake of aspirin and other medicines, as well as keep them out of the reach of children. It is important to remember that preventing poisoning is much easier than curing it.

Possible consequences

Complications as a result of aspirin poisoning:

acute renal, hepatic failure;
lung tissue damage;
toxic hepatitis;
stomach and duodenal ulcers;
bleeding;
metabolic ketoacidosis;
coma.

If timely assistance is not provided as a result of an overdose of Aspirin, death is declared.

For adults, a safe dose of Aspirin is 650 mg, which is 2 tablets (!). Only a doctor can increase it if necessary. Take your medicine, then wait an hour. If there is noise or ringing in the ear, this is a sign of an overdose. If Aspirin is prescribed for you for a course of treatment, tell your doctor about the symptom of overdose, have him adjust the dose.

Acetsitsalicylic acid, especially a large amount of it, acts as a blood-thinning substance that interferes and changes the composition, also irritates the walls of the esophagus, stomach, and the entire gastrointestinal tract.

Therefore, the first symptoms of poisoning appear precisely in:

Vomiting or nausea;
Pain, burning;
blood in the stool;
Sometimes it's a nosebleed;
Temporary decrease in hearing acuity;
Temporary disturbance of the usual indicators of vision.
Aspirin poisoning will pass without consequences if you turn to specialists in time.

So the risk of poisoning increases the simultaneous intake of alcohol. Yes, doctors do not get tired of repeating: take medicines only with water! And it is advisable to drink a full or at least half a glass of liquid. Not tea, not juice, especially not alcohol, you can not drink medicines. You also need to be treated in a sober, sane state.

A severe overdose lets you know the following symptoms:

Consciousness is confused;
Violated, confused thinking;
Lost clarity, sobriety of mind;
There is shortness of breath, even without physical effort;
Increased drowsiness;
The occurrence of tremor;
Sometimes there is suffocation;
The fluid level drops sharply, which leads to dehydration;
Depression ensues;
The harmony of carbohydrate metabolism is disturbed.

Moreover, if you do not turn to specialists in time, a fatal outcome is possible. Watch yourself carefully after taking Aspirin, keep track of the number of pills given to a sick relative, keep track of the time of taking so that there is enough time between sessions. After all, a doctor can determine the severity of poisoning only by knowing the dose of the medicine:

If less than 150 mg, calculated on body weight - the poisoning is weak, perhaps even the absence of symptoms;
When the dose is 150 or 300 mg / kg - this is mild or moderate poisoning. One or two of these symptoms are possible;
Dose from 300 to 500 mg / kg - severe poisoning (urgent help is needed);
More than 500 mg / kg is almost fatal poisoning (this is about 60 tablets, each 500 mg, a child needs much less, 10 g, for poisoning).

In order not to start the situation, you need to carefully monitor the symptoms that will show an overdose. After all, it precedes poisoning. If treatment with Aspirin gave the following symptoms:

There is noise in one or two ears at once;
There is dizziness;
Tachycardia was detected;
The pressure decreases;
Nausea, even vomiting;
Breathing becomes more frequent;
Wheezing appears;
Bleeding;
severe drowsiness;
Allergic reaction.

The latter may appear unexpectedly, even in non-allergic people who have not previously experienced a reaction of this kind. A person could be treated with Aspirin for many years, and the body did not accept it as an allergen, but here it manifested itself. Allergy is manifested in itching or difficulty breathing, anaphylactic shock occurs.

Be sure to contact the doctor, and if it was self-medication, immediately stop taking Aspirin and go to the clinic closest to the house. Be sure to tell them when and how many pills they took, how long the “course” lasts, and what they were actually treated for.

If a person did not pay due attention to the symptoms, then continued treatment will manifest itself in more serious signs:

The occurrence of hallucinations;
Hearing loss (partial or even complete);
Severe, even pathological bleeding;
Confusion, clouding of consciousness;
The occurrence of convulsions;
Increased drowsiness (possibly not passing);
Increased sweating;
causeless fever;
Constant thirst (due to dehydration);
Problems with vision (he will fall hard).

Here, an ordinary doctor is unlikely to help, we need toxicologists who work with emergency poisoning. When the overdose is severe, the consequences are severe, up to 10% dehydration. Children show anxiety, high excitability. The cause of death is a lack of breathing, which will cause pulmonary or cerebral edema, bleeding, as well as shock or severe electrolyte disorders.

Sometimes a poisoned person can no longer stop using Aspirin on his own or cannot call for help. Closely monitor loved ones when they are prescribed courses of medication. You can get poisoned by any drug. To mix up the dosage or not waiting for the effect, people double the dose, believing that four tablets instead of two will “cope” faster.

Alas, pharmacology does not justify the proverb: "more is better", this science encourages extreme accuracy and increased attention to drugs. Aspirin intake should be monitored by relatives at home, and by a doctor at a distance. Especially when a child or teenager is undergoing treatment. After all, parents give medicines to children, and teenagers often take their own medicines. Here you need to watch constantly.

Light and moderate severity of intoxication passes without harm to health with proper treatment. The likelihood of developing multiple organ failure is small.

Of particular danger is long-term intoxication with acetylsalicylic acid. Possible consequences:

kidney failure;
severe liver damage;
violation of higher nervous activity, brain functions;
bronchial asthma - the danger of the form lies in the fact that after recovery, an attack can begin when using any drugs of the NSAID group, which are effective antipyretic and analgesic drugs;
an ulcer that has arisen due to acid damage to the mucous membrane of the stomach, intestines.

Symptoms of chronic aspirin overdose

In chronic overdose of aspirin, the symptoms will be as follows:

noise in ears;
indigestion;
stomach ache;
hearing loss;
nausea, vomiting;
sweating;
headache;
anemia, a decrease in the level of leukocytes and blood platelets;
stupor, loss of consciousness.

Chronic intoxication is dangerous by provoking bleeding, the development of drug-induced bronchial asthma. Prolonged overdose may exacerbate heart failure.

Symptoms of acute aspirin poisoning

Acute poisoning has 3 degrees of severity. With a mild one, the symptoms will be the same as with chronic intoxication, only consciousness in this case will not be disturbed.

With kidney damage, urination decreases. A life-threatening electrolyte imbalance develops. The content of sodium in plasma increases, and potassium decreases.

An aspirin overdose ends in death from acute liver or kidney failure, pulmonary edema, paralysis of the centers of the brain that control breathing and cardiac activity.

First aid and further treatment

Consequences of an aspirin overdose

Preventive actions

In order not to be poisoned by acetylsalicylic acid, it is enough to follow a few recommendations:

Use only after consulting a doctor, especially if you plan to use other medicines at the same time.
Keep away from children.
At the slightest side effects, stop therapy.
Do not combine treatment with drinking alcohol.

If there are risks of poisoning, it is better not to use Aspirin, but to replace with drugs such as Paracetamol, Validol, Heparin.

Simple poisoning, which provoked excessive use of aspirin, has minor consequences, but a more severe one is fraught with dangerous diseases: toxic encephalopathy, ulcers, kidney or liver failure, and other ailments, which ultimately end in disability.

In this regard, it is important to follow the rules for storing medicines and, most importantly, keep them out of the reach of children.

In no case should you violate the doses indicated by the doctor or in the instructions and take the medicine more often than expected.

When it becomes necessary to use other drugs, the doctor who prescribed the aspirin treatment should be informed.

Keep track of the expiration date of drugs and buy them at the pharmacy only from well-known manufacturers. After all, poisoning can also be provoked by the use of counterfeit products, which are not so few on the pharmaceutical market.

All these simple measures will help you prevent the undesirable consequences of the toxic effects of the drug on the body and maintain your health. So be careful and don't get sick!

Large or not very dragees of aspirin have been known to mankind for a long time. They are quite popular among us and are present at home in almost every family. Previously, this medicine was used mainly as an antipyretic drug. Over the years, the spectrum of action of aspirin has expanded significantly.

Now it is prescribed and taken orally for many diseases, without thinking at all that with a large accumulation in the body, an overdose of Aspirin occurs.

Let's figure it out - how can you get poisoned with aspirin and is there a lethal dose of the drug?

Panacea for many ailments

People are used to treating absolutely all diseases with these miraculous pills. Feeling a severe headache, we take aspirin.

With it, we remove the inflammatory process in the body. We “sit” on it when we are sick with ARVI, in the end, thanks to its blood-thinning property, we take it to prevent strokes and heart attacks, and indeed any circulatory disorders, without even thinking, is it possible to get poisoned?

Usually, acetylsalicylic acid poisoning occurs when a person begins to independently increase the dose recommended by the attending physician for greater effect or takes pills for a long time, without doubting the safety of the drug!

IMPORTANT! In our country, poisoning with analgesics (this group also includes aspirin) steadily holds the first place, and with fatal outcomes. In more than 12% of deaths, it is the excessive use of aspirin and its content in other drugs that is recorded.

Especially dangerous is acetylsalicylic acid for the elderly and toddlers or school-age children. Therefore, with any approach to the treatment of any disease, probably, as elsewhere, the main thing is to know when to stop.

Action of Aspirin

Aspirin is easily tolerated by the body, because it is absorbed in the stomach, broken down in the liver and excreted by the kidneys. The price of the drug also speaks in its favor. And the widest spectrum of action indicates that ASA has an unusually many good properties.

That is why doctors use it to treat pain of various locations, feverish conditions and other things.

This non-steroidal anti-inflammatory drug is prescribed when it is necessary to prevent the process of gluing platelets together, that is, to prevent the formation of blood clots. For example, in people with pathologies of cerebral circulation, heart, blood vessels, or in old people diagnosed with atherosclerosis.

In general, if the patient has no contraindications to taking this drug, and he complies with the prescribed therapeutic dose, there are no side effects and the patient tolerates the drug perfectly.

However, if these “rules” are not observed, aspirin poisoning occurs, in other words, the patient develops intoxication.

This usually happens under the following circumstances:

improper self-administration of aspirin;
non-compliance with the recommendations for the use of the drug prescribed by the doctor or in the instructions;
when the child found the pills and ate them;
when the patient specifically, to speed up recovery, without consulting a therapist, increased the frequency of taking the drug or its amount;
with poor functioning of the organs responsible for the absorption and excretion of aspirin, especially when the patient does not even suspect it.

Symptoms of intoxication

An overdose of aspirin according to the severity of the patient's condition (due to the concentration of the active substance in the blood) is divided into three types:

light- has the same symptoms as chronic poisoning only without fainting. In this state, ASA in plasma reaches a level of 150 µg/l;
middle- the victim breathes heavily and often, coughs with sputum, he has a fever, the level of the drug in the blood is 300-500 mcg / l;
heavy- aspirin poisoning has symptoms of respiratory failure and, as a result, pulmonary edema, increased cough, cyanosis of the skin. If there is foamy saliva in one of the corners of the mouth, then this is already a symptom of a critical condition, which is very difficult to treat and leads to death.

In the future, the picture develops as follows: the outflow of urine is disturbed, the electrolyte balance fails (an increase in sodium in the blood and a decrease in potassium), there are signs of confusion, excessive arousal, although of a short duration, followed by lethargy and sleepiness, convulsions and coma.

Thus, an overdose of aspirin and its consequences are really dangerous.

But can death occur from this, and what dose of the drug is unfortunate not only for health, but also for life?

This question is especially interesting for moms and dads whose child accidentally put an entire package of acetylsalicylic acid into his mouth.

It should immediately be noted that it is difficult to get poisoned by aspirin not only by taking a huge dose of medication. It also depends on the person's well-being, the presence of concomitant ailments in the body, weight and other factors of the poisoned person.

It is quite clear that it is much more difficult for babies to overcome such a condition than for an adult, so a fatal outcome is quite possible here.

IMPORTANT! Knowing that in pharmacies aspirin is dispensed in tablets of 0.25 g, it can be calculated that for a person with a weight of 15 kg, the lethal dose in one dose will be 30 tablets of the drug, with packaging of 0.5 g - 15.

Diagnosis - poisoning

Suspecting that an adult or child has aspirin poisoning, you should immediately call an ambulance. Before the arrival of resuscitators, it is advisable to induce vomiting in the poisoned person in order to avoid further spread of toxins, and give him some kind of sorbent to drink, the simplest is activated charcoal.

The health workers who came to the call should be told how much the medicine was drunk, whether other drugs were taken at the same time, and also, if the injured adult, whether alcohol was consumed.

First of all, the doctor will pay attention to breathing, if it is difficult, then the patient will be connected to oxygen. Then, already in the hospital, with the help of the necessary studies, doctors will determine how much the patient's internal organs have suffered, they will also determine the level of aspirin overdose, and with the help of special test strips they will determine the amount of the active substance in the urine.

When the stage of poisoning caused by an overdose of acetylsalicylic acid is established, appropriate therapy is prescribed, aimed primarily at:

an obstacle to the accumulation of toxins in the body - the active substance of the drug;
decrease in the amount of acid taken by the patient;
restoration of acid-base balance.

If very little time has passed since taking aspirin, then the poisoned person immediately “washes” the gastrointestinal tract and drink it with a sorbent. A patient who is unconscious is injected with a liquid sorbent through an umbrella.

For mild dehydration, more fluids are suggested. It can be purified water, fruit juices or milk. When the condition is more severe, special solutions are used that are administered intravenously.

The high temperature is removed with appropriate medicines, and bleeding in the body is “healed” with vitamin K. When the treatment is started as early as possible, the patient recovers quickly.

Preventive actions

In this regard, it is important to follow the rules for storing medicines and, most importantly, keep them out of the reach of children.

In no case should you violate the doses indicated by the doctor or in the instructions and take the medicine more often than expected.

When it becomes necessary to use other drugs, the doctor who prescribed the aspirin treatment should be informed.

Keep track of the expiration date of drugs and buy them at the pharmacy only from well-known manufacturers. After all, poisoning can also be provoked by the use of counterfeit products, which are not so few on the pharmaceutical market.

All these simple measures will help you prevent the undesirable consequences of the toxic effects of the drug on the body and maintain your health. So be careful and don't get sick!

Aspirin is probably one of the most popular drugs in the world. Acetylsalicylic acid has long been scientifically used by people completely independently. The temperature has risen, the head hurts, or the person is afraid of the formation of blood clots, in all cases aspirin is the first assistant. Most do not even realize that an overdose of aspirin is completely real.

How does an overdose happen?

For example, a person who suffers from thrombosis, or thinks he is suffering, finds information about the blood-thinning effect of the drug. Under fear of mortal danger in the form of a blood clot, he begins to absorb the drug in unimaginable doses. The result is acute aspirin poisoning. Or he slightly exceeds the prescribed rate for greater effect, getting chronic poisoning.

Taking the drug, even with a small amount of alcohol in the human body, is toxic.

Unfortunately, not all parents know that acetylsalicylic acid, as an antipyretic drug, is absolutely not indicated in childhood. The consequences will be discussed below.

The main and unifying circumstance in case of an overdose is self-medication. Prescribing doses by eye. Attitude to aspirin, as to ascorbic acid.

Signs of aspirin poisoning.

Chronic poisoning with acetylsalicylic acid can occur in those who take the drug in courses. Symptoms of intoxication are as follows:

Dizziness;
Noise in ears;
Increased breathing, wheezing;
Tachycardia;
low blood pressure;
Nausea or vomiting;
Drowsiness;
nosebleed;
Abdominal pain;
Drowsiness, confusion;
Fainting.

What is dangerous overdose.

The damage done to the body depends on several factors:

The state of human health, the presence of chronic diseases;
The severity of poisoning. For example, mild poisoning does not make significant changes in the functioning of organs;
The speed of first aid for moderate and severe poisoning.

Aspirin poisoning can leave the following imprints:

Bleeding, liquefying effect will make itself felt. Pi this bleeding can be internal;
kidney failure;
Bronchial asthma;
Liver failure;
Stomach ulcer;
encephalopathy;
Coma;
If a lethal dose of 500 mg per kg of body weight was taken, a fatal outcome occurs.

Separately, I would like to add about the dangers of aspirin for children. The combination of a childhood viral infection and acetylsalicylic acid is highly likely to lead to a condition such as Reye's syndrome. The end result of which is death in 80% of cases.

Treatment and first aid.

In case of serious poisoning, it is important to provide first aid as soon as possible in order to stop the destructive effect on the human body.

It is possible that part of the drug has not yet been absorbed by the body, so you need to prevent the absorption process from continuing. At home, you should immediately induce vomiting. Upon arrival, the ambulance will perform a gastric lavage and the introduction of activated charcoal. In the future, to remove the assimilated aspirin, a plentiful drink is provided.

In case of severe consequences, droppers are prescribed, which will speed up the elimination process.

After providing emergency assistance, the degree of consequences of an overdose is revealed, a complex of therapeutic and rehabilitation measures is selected. In any case, the poisoned person will take sorbents for some time.

About the dangers and benefits of aspirin in the video:

Prevention.

Never use medicines on your own. Read at least the instructions. Remember that an overdose is possible even with the use of vitamins. Medicinal herbs and those have contraindications. Aspirin is a serious chemical drug that can be very dangerous, even fatal.