Pentoxifylline 600 mg instructions for use. Pentoxifylline is the best drug for blood circulation

Pentoxifylline is a drug from the group of angioprotectors, the action of which is based on the restoration of blood microcirculation in the capillaries. The drug contains the substance of the same name, pentoxifylline. This medicine has two forms of release:

Tablets of 100 mg of active ingredient each;
Solution for injection 2%, 5 ml – 1 ml contains 20 mg of active substance.

Indications for use of Pentoxifylline

Pentoxifylline is indicated for diseases of various human organs and organ systems, including diseases of the spinal column. These are such as:

Severe bruises of the spine and its structures;
Spinal (spinal) stroke;
Atherosclerosis of spinal vessels;
Spinal fracture and its consequences;

Contraindications to the use of Pentoxifylline

Pentoxifylline is contraindicated for prescription and use in the following conditions and diseases of the patient:

Children under 18 years of age;
Recent surgery (less than a week ago);
Lactation period;
Heart rhythm disturbances (arrhythmia);
Pregnancy at any stage;
Kidney failure;
Allergy to the drug and its components;
Tendency to external and internal bleeding;
Stomach and duodenal ulcers;
Myocardial infarction, acute period;
Liver failure;
Heart failure;
Low blood pressure (hypotension).

How Pentoxifylline works

Once in the patient’s blood, Pentoxifylline reaches the affected capillaries. There, the active substance of this drug helps restore the elasticity of the walls of red blood cells, reduces the increased coagulability of platelets, and improves the rheology (fluidity) of blood by reducing its viscosity. Also, the walls of blood vessels expand somewhat due to a decrease in spasm in them.

Pentoxifylline normalizes and restores metabolism in tissues, stabilizes gas exchange. After a stroke, blood flow through the vessels of the spinal cord quickly normalizes, and nerve conduction is restored (this is possible due to proper nutrition and blood supply to the nerve endings in the affected area).

Instructions for use of Pentoxifylline

Pentoxifylline in tablet form

Pentoxifylline tablets are recommended to be taken orally, without chewing, after meals, with a sufficient amount of liquid, 100-400 mg 2-3 times a day. The maximum permissible daily dosage is 1200 mg of the drug (12 tablets). The course of treatment is selected individually and can vary from 2 weeks to several months.

Pentoxifylline in the form of a solution for injection

The injection solution is intended exclusively for intravenous administration (drip or stream). To prepare a dropper with the drug, mix physiological solution (0.9% sodium chloride) or 5% glucose with 1-6 ampoules of Pentoxifylline and administer this mixture over one hour. Frequency of administration – 1-2 times a day. The maximum daily dosage is 12 ampoules (1200 mg).

For jet administration, 1 ampoule (5 ml) is administered over 5 minutes 1-2 times a day, without diluting.

Side effects of Pentoxifylline

In extremely rare cases, Pentoxifylline may cause side effects. The main ones include the following:

Stomach ache;
Visual impairment;
Vomiting accompanied by nausea;
Convulsions;
Diarrhea, constipation or their alternation;
Increased nervousness;
An attack of angina (short-term compressive pain behind the sternum);
Insomnia at night and drowsiness during the day;
Increased heart rate;
Dizziness;
Reduced blood pressure;
Anaphylactic shock;
Itchy skin;
Headache;
Quincke's edema.

If one or more side effects occur, you should stop taking Pentoxifylline, consult your doctor, rinse your stomach and, if necessary, take symptomatic medications.

If the prescribed dosage of the drug is not observed, the following symptoms may develop:

Increased heart rate;
Nausea;
Increased body temperature;
Vomiting “coffee grounds” (a sign of stomach bleeding);
Convulsions;
Decrease in blood pressure numbers;
Fainting;
Dizziness.

If signs of an overdose of Pentoxifylline occur, it is necessary to rinse the stomach, take symptomatic medications and enterosorbents.

special instructions

During pregnancy and lactation, Pentoxifylline is contraindicated. This is due to the lack of data on the effect of the drug on the fetus and child development.

For children under 18 years of age, the use of the drug is contraindicated because there is no reliable data on its effect on the development of the child.

Drinking alcoholic beverages does not affect the properties of Pentoxifylline.

Pentoxifylline is a peripheral vasodilator derived from dimethylxanthine. It is a modern and effective means of improving the rheological properties of blood. The medication has a pronounced vasodilator and capillary protective effect, and also increases capillary resistance and improves microcirculation.

The drug affects all types of blood vessels in the human body: arterial, venous, capillary. Taking Pentoxifylline can improve the tone of the respiratory muscles and stop the processes of thrombosis.

The angioprotector is indicated for use in complex therapy of diseases of the cardiovascular system. The drug is used in clinical practice for the treatment of cerebral vessels and venous insufficiency.

The mechanism of action is due to inhibition of phosphodiesterase and accumulation of cyclic adenosine-monophosphoric acid with a decrease in the concentration of intracellular calcium in vascular smooth muscles and blood cells. The drug also inhibits the aggregation process, while increasing the elasticity of the vascular wall and reducing the level of fibrinogen in the plasma, as well as accelerating fibrinolysis.

Release form

The solution for injection is clear, colorless or slightly yellowish. It is used for injections and IVs.

Tablets coated with a pink, film-coated enteric coating. One tablet contains 100 mg of the active substance pentoxifylline.

The concentrate and solution of the drug for IV and IM administration contain 20 mg of pentoxifylline per 1 ml. The solution for infusion may also contain 2 mg per 1 ml.

Active substance

The drug contains the substance of the same name, pentoxifylline. Once in the patient’s blood, this compound penetrates into the affected capillaries. There, the active substance of the drug helps restore the elasticity of the walls of red blood cells, reduces the increased coagulability of platelets, and improves the rheology (fluidity) of blood by reducing its viscosity. In addition to this, the drug tones the muscles involved in the breathing process - the diaphragmatic and intercostal muscles.

Indications for use

According to the official instructions, Pentoxifylline is prescribed for:

gangrene;
postthrombotic syndrome;
varicose veins;
viral neuroinfection;
trophic ulcers of the leg;
cerebral atherosclerosis;
violation of tissue trophism;
severe bruises of the spine and its structures;
spinal (spinal) stroke;
Bekhterev's disease;
atherosclerosis of spinal vessels;
osteochondrosis;
spinal fracture and its consequences;
radiculitis;
Raynaud's disease;
obliterating endarteritis;
disturbances in the peripheral blood supply;
frostbite;
dyscirculatory encephalopathy;
obliterating atherosclerosis - a disease in which special plaques developing in the lumen of blood vessels lead to disruption of blood supply, and, as a result, narrowing or blockage of the arteries occurs;
diabetes mellitus;
varicose veins;
bronchial asthma and other pathologies of the respiratory system;
hearing impairment due to dysfunction of the inner ear;
ischemic stroke;
with sexual impotence in men of vascular origin.

For acute forms of the disease and complications, the drug is prescribed in ampoules.

Instructions for use Pentoxifylline + dosages

Prescribed orally, intravenously and intra-arterially.

Intravenously administered slowly, calculated according to the scheme: 50 mg for every 10 ml of sodium chloride 0.9%, administered for 10 minutes, after which they switch to administration by dropper: 100 mg diluted in 250-500 ml of sodium chloride 0.9% or dextrose solution 5 %.

Intra-arterial: 100 mg diluted in 20-50 ml of sodium chloride.

100-200 mg is administered intramuscularly three times a day.

Take orally, starting with 0.2 g (2 tablets) 3 times a day after meals, without chewing. After the onset of the therapeutic effect (usually after 1-2 weeks), the dose is reduced to 0.1 g (1 tablet) 3 times a day. The course of treatment is 2-3 weeks. and more. The tablets should be taken after meals, without chewing, with a sufficient amount of liquid. The maximum daily dose should not exceed 1200 mg.

The duration of the course of therapy and the daily dose are regulated by the doctor for each individual patient individually - it depends on the diagnosis, the severity of clinical symptoms and the characteristics of the body.

Features of application

When taking the drug, drinking alcoholic beverages is strictly prohibited, since the main substance of the drug can cause an extremely negative reaction of the body to ethanol.

According to the instructions, Pentoxifylline solution can be administered intraarterially or intramuscularly only when the patient is in a supine position.

In smoking patients, the therapeutic effectiveness of Pentoxifylline may be reduced.

The drug has a number of features, so before use it is necessary to consult a specialist. The effect of pentoxifylline can occur between the 2nd and 4th weeks, but treatment should continue for at least 8 weeks.

Considering that sensitive patients may experience adverse reactions when using the drug (dizziness, blurred vision, weakness), during the period of taking the drug you should refrain from driving any vehicles and performing other work that requires increased precision.

Side effects and contraindications

Nausea, vomiting, pain and feeling of heaviness in the epigastric zone, diarrhea, headache, dizziness, asthenia, tachycardia, angina attacks, arterial hypotension, arrhythmias, flu-like syndrome, nasal congestion, anorexia, intestinal atony, increased activity of liver enzymes, leukopenia, thrombocytopenia , exacerbation of cholecystitis.

Also, side effects in patients were allergic reactions to the administration of the drug (facial skin flushing, itching, urticaria), bronchospasm, angioedema, blurred vision, and various bleedings.

A complete list of side effects from all organs and systems is described in the annotation attached to the medication. If after using the drug any negative reactions begin to appear, then the use of Pentoxifylline should be excluded.

Overdose

In case of a severe overdose of the drug, reactions such as nausea, vomiting, arrhythmia, severe headaches, tachycardia, chills, convulsions, allergic reactions and others may occur.

Treatment: symptomatic. Gastric lavage is performed and activated charcoal is prescribed. The patient should be placed in a horizontal position with legs elevated. A specific antidote is unknown. Carry out monitoring of vital functions and general measures aimed at maintaining them, monitoring the patency of the respiratory tract; for convulsions, diazepam is administered.

Contraindications

Hypersensitivity to pentoxifylline and other xanthine derivatives; acute myocardial infarction; porphyria, massive bleeding, hemorrhagic stroke, retinal hemorrhage, pregnancy, lactation. For intravenous administration (optional) - arrhythmias, severe atherosclerosis of the coronary or cerebral arteries, uncontrolled arterial hypotension.

Caution should be exercised when prescribing Pentoxifylline to patients with gastric and duodenal ulcers, patients, or those who have recently undergone surgery (risk of bleeding).

Analogs of Pentoxifylline, list of drugs

Analogues of the drug in terms of application and indications are:

Dibazol;
Trental;
Vazonite;
Magnesium sulfate;
Polfilin retard;
Pentoxifylline solution;
Pentohexal;
Radomin;
Agapurin;
Flexital;
Latrain.

Important - instructions for use of Kagocel, price and reviews do not apply to analogues and cannot be used as a guide to the use of drugs of similar composition or action. All therapeutic prescriptions must be made by a doctor. When replacing Kagocel with an analogue, it is important to consult a specialist; you may need to change the course of therapy, dosages, etc.

Don't self-medicate!

During pregnancy, special demands are placed on the condition and health of the mother. It’s good when everything goes smoothly, but usually complications cannot be avoided. The problem is that the number and types of drugs mothers can take during pregnancy are severely limited. Therefore, when mothers are prescribed Pentoxifylline during pregnancy, this can become a serious cause for concern. And, indeed, the use of the drug at this time may be limited. But sometimes it is still prescribed - and for good reason.

When is the drug prescribed to pregnant women?

During pregnancy, expectant mothers may experience various unusual situations, but one of the most dangerous complications is FPI - fetoplacental insufficiency. Its essence lies in the fact that blood circulation between the mother, placenta and fetus is disrupted. The problem can occur in both acute and chronic forms.

The consequences of developing any form of this disease can be negative. In the “best” cases, a delay in the baby’s development may occur; in the worst cases, a miscarriage may occur. Therefore, although the instructions for use formally prohibit Pentoxifylline during pregnancy, sometimes the doctor can still prescribe it as an exception, after looking at the patient’s testimony. During pregnancy, the drug acts as follows:

It makes the blood more fluid. This facilitates the movement of blood through the vessels, so the placenta is much more easily supplied with oxygen, and there are fewer negative risks.
Blood microcirculation improves noticeably. This is very important for the overall health of the child.
The vessels dilate, which also helps improve the aforementioned connection between mother, baby and placenta.

Prescription for pregnant women

But still, the instructions for use prohibit the drug during pregnancy, therefore, if its use was forced, you need to at least very carefully monitor the patient’s condition and look at her testimony. There are a few things to consider:

The patient's condition. If everything is critical, then it is necessary to prescribe Pentoxifylline in any case.
Gestational age. It is not recommended to prescribe Pentoxifylline before the 20th week, because the formation of the child’s organs occurs precisely by this period of time.

It is important to remember that a pregnant woman cannot independently make a decision about taking this drug; the doctor confirms the indications. The appointment must be made by the attending physician. But just as you shouldn’t start taking it personally, you shouldn’t give in to panic if a doctor prescribed it during pregnancy. Although the instructions for use formally prohibit the drug, in general there are usually no problems - and the child has a much better chance of health than if the drug is not taken in a timely manner.

When to use

There are other indications when this drug is prescribed to patients. These include:

impaired blood circulation in the eye vessels;
dysfunction of the middle ear due to problems with blood vessels;
trophic disorders of organs and tissues that are associated with thrombosis of veins or arteries, as well as frostbite and varicose veins;
diabetic angiopathy;
cerebral ischemic stroke;
the consequences of atherosclerosis, which caused disturbances in the blood circulation of the brain;
encephalopathy of discirculatory type;
disorders of peripheral blood formation.

For these pathologies, Pentoxifylline will have a very positive effect. He:

increase the elasticity of red blood cells and platelets;
will reduce the aggregation of red blood cells and platelets;
reduce blood viscosity;
will increase microcirculation in many organs;
will have an angioprotective effect.

In order for Pentoxifylline to have a similar effect, its instructions for use must be followed exactly. It is highly recommended not to use it on your own, without consulting a doctor.

Side effects

As the attached instructions for use state, the drug has a number of characteristic side effects. These include:

lowering blood pressure;
vomit;
nausea;
headache;
dizziness.

The last few symptoms appear more often if Pentoxifylline is used in tablet form. With a dropper, the manifestations are much milder, so usually this form is preferable when problems arise, and it is with it that the readings will be better.

Application

If indications for use nevertheless arise, the instructions indicate that Pentoxifylline must be administered intravenously using a dropper as follows.

Atherosclerosis, varicose veins and many other diseases can be cured by Pentoxifylline tablets or solution. Today we will determine how to properly treat this drug, whether it has side effects, whether there are restrictions on its use, and also find out the opinions of patients who have tried it on themselves.

Pharmacodynamics

The medicine “Pentoxifylline”, reviews of which we will describe in this article, affects the patient’s body in the following way: it improves microcirculation in areas of impaired blood supply, increases oxygen saturation in tissues, and reduces blood viscosity. The drug is also able to increase the elasticity of red blood cells and cause platelet breakdown. In addition, it dilates the coronary arteries and pulmonary vessels. The product also increases the tone of the diaphragm and intercostal muscles, and has a positive effect on the performance of the central nervous system.

Indications for use

The drug "Pentoxifylline", the instructions for which must be included with the medicine, is prescribed to patients with the following diagnoses:

Obliterating atherosclerosis is a disease in which special plaques developing in the lumen of blood vessels lead to disruption of blood supply, and, as a result, narrowing or blockage of the arteries occurs.
Diabetes.
Varicose veins
Trophic ulcer.
Gangrene.
Bronchial asthma.
Frostbite.
Ischemic stroke.
Postthrombotic syndrome.
For various cerebral circulatory disorders.
For sexual impotence in men of vascular origin.
Chronic lung diseases.

Restrictions

Not all patients can be treated with Pentoxifylline tablets. Indications for the use of this drug are described in the previous subsection, and now we should consider which categories of patients are prohibited from receiving therapy with this drug. So, if you have the following health problems and body characteristics, you should not take Pentoxifylline tablets:

In acute myocardial infarction.
In case of obvious disturbance of heart rhythm.
If there was hemorrhage in the retina of the eye.
If there is an ulcer in the stomach or duodenum.
If there was a cerebral hemorrhage.
In case of violation of blood clotting parameters.
With uncontrolled arterial hypotension.
With severe coronary or cerebral atherosclerosis.
Age under 18 years is also a limitation in treatment with Pentoxifylline. Indications for the use of this drug indicate that the effectiveness of these tablets, as well as their safety in relation to children and adolescents, have not been established.
In case of pregnancy or when feeding the baby with breast milk.
In case of hypersensitivity to the components of the drug.

Release form

The drug is sold in two forms:

Solution. It is used for injections and IVs.
Pills.

Ampoules "Pentoxifylline": indications for use

The drug in the form of an injection solution is intended only for intravenous administration (drip or stream). The medicine is administered in this way only in cases of severe cerebral circulatory disorder or peripheral hemodynamics. In other cases, you need to use Pentoxifylline tablets. The dropper is placed like this: saline solution is mixed with 1-6 ampoules of the drug, the resulting mixture is administered over 60 minutes. You can do this procedure up to 2 times a day. For jet administration, use 1 ampoule for 5 minutes 1 or 2 times a day. In this case, there is no need to dilute the medicine with another remedy.

Pentoxifylline tablets: indications for use

Pills should be taken after meals, 100-400 mg 2 or 3 times a day. At the same time, they do not need to be chewed or bitten, they just need to be swallowed and then washed down with a sufficient amount of water. The maximum permissible daily dose of the drug is 1200 mg, which is equivalent to 12 tablets.

The course of therapy is selected for each patient and can vary from 2 weeks to 6 months or longer.

Price

The cost of a medicine is influenced by several factors: the dosage of the drug, the form of sale, as well as the manufacturer of the drug Pentoxifylline. Tablets, the price of which, by the way, is low, can be purchased on average for 40 rubles (that’s 60 pills). And for a 2% injection solution (5 ml ampoule) you will have to pay about 60 rubles. This is the approximate cost of the drug Pentoxifylline. The price of its analogues is much more expensive and ranges from 160-300 rubles (for the medicine “Trental”) and from 90 to 130 rubles for the medicine “Agapurin”.

People's opinions

The drug "Pentoxifylline", reviews of which can be found on various forums, has mostly positive responses. Firstly, patients note the effectiveness of the medicine: blood circulation improves, pain subsides, the feeling of numbness in the feet goes away, patients sleep well at night, and general relief is felt.

Secondly, compared to analogues of the drug, Pentoxifylline can be purchased quite inexpensively. The tablets, the price of which is quite affordable, can be purchased by anyone, since the medicine is domestic. But its analogues are foreign medicines, which is why they cost much more, although the effect is the same. Therefore, in order not to overpay, it is better to purchase a Russian drug for the treatment of diabetes, atherosclerosis, impaired cerebral circulation, trophic ulcers, etc.

Thirdly, the speed of impact. Many people write that after just one course of taking this medication they felt relief, their head became light, breathing easier, and blood flow to their legs and hands quickly improved. This is especially important for people who are constantly cold, so they should take note and remember the name of the drug so that, if possible and according to the doctor’s recommendations, they use Pentoxifylline tablets. There are also negative reviews, but there are only a few of them, and they are associated with the occurrence of side effects in patients. For example, stomach pain, itchy skin, hives, fever. If undesirable reactions are observed after using the product, then it is worth replacing it with something else if possible.

Similar drugs

Many medications have analogues that are produced so that patients have the right to choose, and manufacturers increase their income. The drug “Pentoxifylline” was no exception in this case. Analogs of this medicine differ in price, and moreover, but the active ingredient in them is the same - pentoxifylline.

Similar means of the type described in this article are the following: tablets “Trental”, “Pentohexal”, “Radomin”, “Agapurin”, “Vazonit”, “Flexital”, “Latren”. The drug "Pentoxifylline", analogues of which can be purchased at any pharmacy, cannot be changed independently. If for some reason this medication is not suitable, then it should be replaced only after consultation with a doctor.

Side effects and overdose

Only in extreme cases can this drug cause unwanted reactions. The main ones include: abdominal pain, blurred vision, vomiting, diarrhea, nervousness, insomnia, rapid heartbeat, itchy skin, decreased blood pressure.

If any of the symptoms described above are noted, you should stop taking Pentoxifylline tablets and consult a doctor.

If this medication is taken uncontrolled (in large quantities), the patient may experience the following problems: decreased blood pressure, drowsiness, convulsions, vomiting, fever, etc. In this case, you should call an ambulance as soon as possible, rinse the stomach, take a few pills activated carbon (1 tablet per 10 kg of body weight). An overdose of this drug usually requires hospitalization of the patient.

Now you know for what diagnoses the doctor can prescribe the drug Pentoxifylline. The tablets should be used strictly according to the doctor’s recommendations. But the medicine in the form of ampoules is suitable only for those patients who are in hospital treatment. Reviews about the drug are mostly positive, so if a doctor prescribes an analogue of this drug, which is 3 or even 4 times more expensive, then it is better to purchase Pentoxifylline pills, the instructions for use of which are quite clear to anyone.

Active substance Pentoxifylline .

The tablets contain 100 and 400 mg of this substance.

Additional elements: titanium dioxide, lactose, potato starch, propylene glycol, magnesium stearate, hypromellose, povidone, methacrylate copolymer dispersion, talc, carmoisin.

The solution concentrate and Pentoxifylline solution for intravenous and intravenous administration contain 20 mg of the substance per 1 ml. The solution for infusion may also contain 2 mg per 1 ml.

Release form

Tablet form, as well as solution concentrates and solutions for intravenous and intravenous administration in ampoules.

pharmachologic effect

Antispasmodic . Improves microcirculation, has angioprotective, antiaggregation effects. Dilates blood vessels.

Pharmacodynamics and pharmacokinetics

The medication has a positive effect on the blood properties of the blood, moderately improves microcirculation , saturates with energy potential and increases the concentration of cAMP in, inhibits phosphodiesterase, causes vasodilation , does not affect heart rate. The drug increases the lumen of the coronary arteries, which significantly increases the amount of oxygen supplied to the myocardium ( antianginal effect ); dilates the pulmonary vessels, which improves blood oxygenation . The drug increases the tone of the diaphragm, intercostal muscles and respiratory muscles. When administered intravenously, collateral circulation increases and increases the volume of blood flowing through a sectional unit. Pentoxifylline has a positive effect on the bioelectrical activity and activity of the nervous system, increases the level of ATP in the brain. The use of the drug increases the elasticity of red blood cells (due to the effect on the pathological deformability of red blood cells), causes platelet disaggregation, and reduces blood viscosity . In areas with impaired blood supply, the drug significantly improves microcirculation. Pentoxifylline eliminates pain and cramps in the calf muscles, allows you to increase the walking distance in case of (occlusive damage to peripherally located arteries).

Absorbed quickly. Most of it is excreted in the urine as metabolites, less - in feces. The maximum concentration of the substance is reached an hour after application.

Indications for use of Pentoxifylline

What are the tablets and solution for? The drug is prescribed for disturbances in the peripheral blood supply, disruption of tissue trophism, Raynaud's disease , obliterating endarteritis, postthrombotic syndrome , with frostbite, gangrene, trophic ulcers of the leg, varicose veins, cerebral, viral neuroinfection, dyscirculatory. Also, indications for the use of Pentoxifylline are: post-existing coronary heart disease, bronchial asthma, acute disturbances in the blood supply to the retina, choroid, otosclerosis , impotence of vascular origin.

Contraindications

Pentoxifylline is not prescribed for intolerance to xanthine derivatives, porphyria, acute myocardial infarction, hemorrhagic , massive , retinal hemorrhages , . Intravenous injections of the drug are unacceptable in case of uncontrolled arterial hypotension, severe atherosclerosis of the cerebral and coronary arteries, and. In case of instability, after surgical interventions, with ulcerative lesions of the digestive system, chronic heart failure, pathology of the renal and hepatic systems, the drug is prescribed with caution.

Side effects

Nervous system: convulsive syndrome , .

Skin: increased fragility of the nail plates, swelling, hyperemia of the skin, “flushes” to the skin of the face and body.

Digestive system: cholestatic hepatitis , exacerbation, intestinal atony, loss of appetite, dry mouth.

Cardiac system: cardialgia , drop in blood pressure, progression.

Possible disturbance of visual perception, scotoma, thrombocytopenia, intestinal bleeding, increased activity of liver enzymes, alkaline phosphatase.

Instructions for use of Pentoxifylline (Method and dosage)

Pentoxifylline solution, instructions for use

The drug in ampoules is administered intramuscularly and intraarterially with the patient lying down.

In case of pathology of the renal system, the dosage is reduced to 50-70 percent of the standard dose.

Intravenously administered slowly, calculated according to the scheme: 50 mg for every 10 ml of sodium chloride 0.9%, administered for 10 minutes, after which they switch to administration by dropper: 100 mg diluted in 250-500 ml of sodium chloride 0.9% or dextrose solution 5% .

Intra-arterial: 100 mg is diluted in 20-50 ml of sodium chloride.

Intramuscularly 100-200 mg is administered deeply three times a day.

Pentoxifylline tablets, instructions for use

In addition to parenteral administration, it is permissible to take the drug orally after meals, twice a day, 800-1200 mg. The initial daily dosage in tablet form is 600 mg, gradually the amount of the drug is reduced to 300 mg per day. Long-acting forms of the drug are taken twice a day.

Overdose

Taking increased doses of the drug Pentoxifylline causes a drop in blood pressure, dizziness, tachycardia, fainting, hyperthermia, agitation, tonic-clonic seizures , areflexia, vomiting "coffee grounds" and other signs of bleeding from the digestive tract. Timely rinsing of the digestive system, taking enterosorbents, and symptomatic therapy are required. If bleeding develops, emergency measures are taken to stop the bleeding.

Interaction

Pentoxifylline is able to enhance the effectiveness of medications that affect the functioning of the blood coagulation system (thrombolytic agents, anticoagulants), valproic acid . Pentoxifylline increases the effectiveness of oral hypoglycemic agents, insulin, and antihypertensive medications. Cimetidine can increase the level of the drug in the blood, which means the risk of side effects increases. When administered together with other xanthines, nervous excitement is noted.

Terms of sale

Requires a prescription.

Storage conditions

Keep out of the reach of children at a temperature of no more than 30 degrees Celsius.

Best before date

No more than 3 years.

special instructions

Treatment with Pentoxifylline is carried out under the control of blood pressure. In patients with diabetes mellitus additional dosage adjustment of hypoglycemic agents taken is required. When administered simultaneously anticoagulants control over blood coagulation system . In patients after surgical interventions, hemoglobin and hematocrit are monitored. If blood pressure is unstable, the dose of the drug is reduced. Tobacco smoke reduces the effectiveness of the drug. The compatibility of infusion solutions with Pentoxifylline must be checked before each infusion.

Pentoxifylline is often used in bodybuilding and sports. This is due to the fact that the drug improves blood circulation, causing a strong “pumping” that can last for several hours. However, you should remember that this is a medicinal product, and you should not joke with your health by uncontrollably taking such medications.

Recipe in Latin:

Rp.: Tab. Pentoxyphillini 0.1 No. 60
D.S. 1 tab. 3 times a day

Pentoxifylline analogs

Level 4 ATX code matches:

A complete match between the ATC code and the active ingredients was recorded for the following Pentoxifylline analogues: Latrain , Pentilin , Pentoxipharm , Pentoxifylline NAS, .

Reviews of Pentoxifylline

Based on many opinions, we can conclude that the drug is truly effective in helping to cope with problems of the vascular system. Effectively helps with improving blood circulation.

Often and effectively used for obliterating endarteritis.

Reviews of Pentoxifylline during pregnancy

Although the drug is contraindicated during this period of life (due to a lack of research), doctors often prescribe it for feto-placental insufficiency, for example, a Pentoxifylline drip during pregnancy. The opinions of those who used the medicine were generally positive; no side effects were noticed.

Pentoxifylline price, where to buy

The price of Pentoxifylline in 0.1 g tablets ranges from 85 to 130 rubles per pack of 60 pieces.

The price of Pentoxifylline ampoules 2%, 5 ml each, is 40 rubles for 10 pieces.

Online pharmacies in Russia Russia
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Online pharmacies in Kazakhstan Kazakhstan

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