Will a unicorn horn help, or What is Anaferon? Affinity purified antibodies to human interferon gamma Use during pregnancy and lactation.

Production

The production technology of the drug, according to the manufacturer, includes immunization of rabbits with recombinant human interferon gamma to obtain antibodies to human interferon gamma. Antibodies to human gamma interferon, which are declared as the active ingredient of Anaferon, are isolated from the blood serum of an immunized animal using the affinity purification method on an adsorption column.

The resulting antibodies undergo a potentiation procedure. The initial solution is repeatedly diluted sequentially (from 12 to 50 times) with an aqueous-alcohol solution in the ratio of 1 part antibody solution and 99 parts aqueous-alcohol solution.

pharmachologic effect

Due to the fact that this drug is a homeopathic drug, the concentration of the active substance in it is extremely low (up to a very high probability of complete absence of active substances in a particular pill) and the concentration of impurities significantly, by many orders of magnitude, exceeds the content of the main substance of the drug. The therapeutic effect of the drug Anaferon, like all known homeopathic remedies, is due to the placebo effect. The physiological mechanism by which antibodies to human interferons could have an immunomodulatory effect is unknown.

According to the manufacturer, the drug has an immunomodulatory effect and prevents the development of the influenza virus, as well as a number of other viral infections:

pharmachologic effect: immunomodulatory, antiviral. Stimulates the humoral and cellular immune response. Increases the production of antibodies (including secretory IgA), activates the functions of T-effectors, T-helpers (Th). Increases the functional reserve of Th and other cells involved in the immune response. Induces the formation of endogenous “early” interferons (alpha/beta) and gamma interferon (IFN-gamma). It is an inducer of a mixed Th1- and Th2-type immune response: it increases the production of Th1 (IFN-gamma, IL-2) and Th2 (IL-4, 10) cytokines, modulates the balance of Th1/Th2 activities. Increases the functional activity of phagocytes and NK cells. Reduces the concentration of the virus in affected tissues. Has antimutagenic properties.

Studies supporting claims have been published in non-reputable scientific journals.

The method by which antibodies to interferon can help in the prevention or treatment of influenza and ARVI is not known to science.

Declared composition

Anaferon is a tableted mixture of sweetener and ballast substances.

According to the manufacturer, 1 tablet contains affinity-purified antibodies to human interferon gamma: a mixture of homeopathic dilutions C12, C30 and C200 - 3 mg, lactose monohydrate, magnesium stearate, microcrystalline cellulose - the rest of the weight. Dilutions C12, C30 and C200 mean that the active substance in the drug is diluted 100 12, 100 30 and 100 200 times, respectively. According to the instructions, the active substance is an aqueous-alcoholic solution of antibodies to γ-interferon in a concentration of no more than 10–15 nanograms per gram. The mass of antibodies contained in the tablet should be 3·10−27 grams. Moreover, the mass of one antibody molecule is significantly greater than the amount of active substance contained in one Anaferon tablet according to the manufacturer’s statement.

The molecular weight of class G immunoglobulin is 150 kDa, or one molecule has a mass of about 2.5·10−19 grams. The mass of homeopathic antibody dilutions declared by the manufacturer is 3 mg per tablet. Then 3 mg of the active substance contains 3·10−3 g × 10−24 = 3·10−27 g of antibodies (in the approximation that the active substance is only the C12 dilution). The ratio of the mass of the antibody in the tablet to the mass of one antibody molecule gives 3·10−27 ÷ 2.5·10−19 ~ 10−8 molecules. Thus, the probability that a given tablet contains at least one molecule of the active substance is negligible (about 10 −8)

Modern research methods are not able to confirm or refute the presence of such small quantities of the substance in the drug. Accordingly, the drug Anaferon violates one of the requirements for medicinal products - compliance with the same concentration of the active substance in the drug.

A simple calculation shows that one molecule of this active substance is contained in one hundred million tablets. Probably, Materia Medica produces about the same amount and the same amount is bought in pharmacies by people who care about their health and the health of their children.

Notes

Literature

Epshtein O. I., Shtark M. B., Dygai A. M., Sergeeva S. A., Goldberg E. D., Petrov V. I., Voronina T. A., Starostina M. V. Pharmacology of ultra-low doses of antibodies to endogenous function regulators. - M.: Publishing House of the Russian Academy of Medical Sciences, 2005.
Okhotnikova E. N., Yakovleva N. Yu. The effectiveness of “Anaferon for children” in the complex treatment of preschool children with acute respiratory infections // Modern Pediatrics. - 2009. - No. 4.
Kramarev S. A., Kostinskaya N. E. The place of “Anaferon for children” in rational pharmacotherapy of acute respiratory viral infections in children // Modern Pediatrics. - 2005. - No. 4.

Links

Kholodova E. Anaferon: homeopathic refrain of a charlatan composition. // website of Dr. Evgeniy Komarovsky (10/15/2009). Archived Original article. // fraudcatalog.com (05/24/2008). Archived from the original on December 5, 2012. Retrieved December 3, 2012.

Wikimedia Foundation. 2010.

See what “Anaferon” is in other dictionaries:

Dictionary of medicines

Anferon for children (antibodies to human interferon gamma, affinity purified) is a broad-spectrum immunomodulator. Used for the treatment and prevention of influenza and acute respiratory viral infections in children over 6 months of age. A highly effective and safe drug.... ... Wikipedia

Pharmacological groups: Immunomodulators ›› Antiviral drugs Nosological classification (ICD 10) ›› A49 Bacterial infection of unspecified localization ›› B00 Infections caused by herpes simplex virus ›› B34… … Dictionary of medicines Wikipedia

Influenza Micrograph of the influenza virus, taken using an electron transmission microscope, magnified approximately one hundred thousand times ICD 10 J10., J ... Wikipedia

“Make posset with white wine and skim off the foam. Take stallion dung, as warm as possible, and mix it with the drink, add a little Metridate, Carduus Benedictus and unicorn horn, and if there is no unicorn horn, then take ivory or fish tooth and give the patient a drink in the morning on an empty stomach. Repeat the treatment two or three times in a row." (“A Closet for Ladies and Gentlewoman”, 1611)

For a modern person, this recipe for treating fever will only cause a smile and purely historical interest. Nowadays, hardly anyone would risk being treated with warm manure or fish teeth, rightly considering these remedies to be useless. However, is the difference between modern man and our ancestors, who relied on the recipes of medieval healers, really so great?

In the vast majority of cases, fever is a sign cold or flu. And in most cases, the local therapist will prescribe a course of the extremely popular drug Anaferon in Russia as treatment. In 2009, Anaferon's sales volume came close to 1.5 billion rubles. What do patients receive in exchange for this astronomical amount?

Anaferon is the first strange thing. Anaferon appeared on the market in 2002 as a result of research by a pharmaceutical company. By the way, the company itself arose in 1993, when “a group of enthusiastic scientists decided to make their dream come true: to develop and launch affordable and safe homeopathic medicines on the market.” If you still remember that time, then you understand that then it could only be about making money, but not about “intensive scientific research.”

Nevertheless, the company’s specialists were the first in Russia to begin mass production of complex homeopathic medicines, thereby radically distorting the basic principles homeopathic treatment. A few years later, this became so obvious that it even required changing the instructions for Anaferon.

Here is the current description from the manufacturer's website. Anaferon - lozenges. A drug for the safe treatment and effective prevention of influenza and ARVI. Active components: affinity purified antibodies to human gamma interferon - 0.003 g (administered in the form of an aqueous-alcohol mixture of the active form of the active substance containing no more than 10^-15 ng/g of the active substance). Excipients: lactose, microcrystalline cellulose, magnesium stearate.

But on the Internet you can find another, old, description of “Anaferon”. Homeopathic lozenges. Ingredients: affinity purified antibodies to human interferon gamma - a mixture of homeopathic dilutions C12, C30 and C200, excipients: lactose, microcrystalline cellulose, magnesium stearate.

What's the matter? Why did any mention of the homeopathic properties of the drug disappear from the description? It turns out that in the fall of 2009, after reviewing new data regarding the mechanism of action of the drug, the manufacturer decided that homeopathy was not suitable for Anaferon! That is, for seven years the manufacturer was simply confident in the homeopathic properties of Anaferon, and then - suddenly it was cut off. There is no homeopathy here! But the composition of the tablets and production technology remained the same! They are more difficult and more expensive to change than the content of the description. And why?

Anaferon is the second strange thing. Numerous studies have proven that interferon has antiviral and immunostimulating effects. Likewise, it has been proven that in some cases, when interferon is used, specific antibodies are formed in the body, which reduce the effectiveness of interferon treatment. And this immune response most often forces you to stop using interferon. That is, antibodies to interferon contained (maybe?) in Anaferon can only cause inhibition of the action of endogenous human interferon. To increase the production of one's own interferon, interferon inducers are used, to which Anaferon refers no more than any other consonant word.

Anaferon is the third strangeness. The cost of the drug Anaferon is from 120 to 160 rubles per package of 20 tablets. The high cost of medications is most often explained by the high cost of the initial substance used for their manufacture. Often such a substance is not produced in Russia at all, and transportation and customs clearance costs are added to the price of the substance itself. Unfortunately, this is not the case. The main substance for Anaferon is lactose. Anyone can buy it, whether imported or domestic. The imported price is 70-80 rubles for a small bag weighing 25 kg.

Oh yes! There's also “antibodies to human interferon gamma, affinity purified”. The production technology involves immunizing rabbits with recombinant human interferon gamma, after which the desired antibodies are isolated from the rabbit's blood serum on an adsorption column. Need a rabbit farm? Difficult and expensive?

Let's approach this from a different angle. One molecule of precious antibodies has a mass of about 2.5x10^−19 grams, and one tablet contains about 3x10^−27 grams. It is not difficult to calculate that the entire annual production of Anaferon requires only about four molecules! From one rabbit you can extract antibodies for the next couple of million years of production. Our rabbit farm quietly deflated.

And in the end - the sale of milk sugar at a price of 30 thousand rubles per kilogram. The drug business nervously smokes on the sidelines, arms dealers are choking with saliva from envy, the oligarchs of the fuel and energy complex feel like beggars. Almost 1,000,000% (million percent!) profit - and everything is legal!

Anaferon is the fourth strangeness. Why is Anaferon so popular, especially among pediatricians? The answer to this question is also logical.

I will write useful but easy recipes. Well, for example, natrii salicilici 0.5, one powder three times a day... “You can prescribe soda!” - my internal interlocutor responded, clearly mocking. (M. Bulgakov. Notes of a young doctor).

I must say that even the malicious inner voice did not think of prescribing sugar for patients. Nevertheless, Anaferon is an ideal medicine. Its appointment does not threaten the slightest complications, and colds, as you know, go away within a week. With pills, however, seven days in advance.

On the official website of Anaferon, a frightened father asked: “My child ate a whole package of Anaferon, what should I do?” “Don’t do anything, no one has ever died from 3 grams of sugar,” was the meaning of the manufacturer’s response.

A much more interesting question is how did Anaferon get on the list of vital and essential medicines? But the answer to this question lies far beyond medical expediency.

Anaferon is the fifth strangeness. There is not a single imported analogue of a drug that is so beneficial for Russian people. In the 10 years since the appearance of Anaferon, not a single foreign pharmaceutical company has become interested in it. That is, despite the fact that viral diseases occur all over the world, treatment with the highly effective and safe drug Anaferon is accepted only in Russia.

Therefore, the next time you go to the pharmacy for Anaferon, think - is it worth it? Believe me, this drug can be successfully replaced with much more effective and tasty cranberries in sugar. And allow Anaferon, as well as other equally “effective” drugs, for example, Artrofoon, Afale, Dietress, Impaze, Proproten-100, Tenoten, Ergoferon, to take their rightful place in the “Curiosities and Misconceptions” section of the textbook on the history of medicine.

Oleg Antonov

Ergoferon, anaferon and other bullshit. How they deceive us.
Spring is the time for colds and viral infections. But if you go to the pharmacy, you will find that on the shelf with antiviral drugs, about half of the contents are dummies that have nothing to do with drugs. Pharma scammers are making billions off your gullibility.
Well, there are still Russian drugs developed during perestroika, which do not have evidence of effectiveness according to international standards of evidence-based medicine, but only a few domestic works (we are talking about the notorious Arbidol and, for example, cycloferon), but on the shelves there are many products that, by definition, are not medicines or antiviral drugs , if only simply because they have no active ingredients, they are dummies. We are talking about homeopathy such as anaferon, oscillococcinum, aflubin and ergoferon. And if, according to the first two information on the Internet, there is a sea (yes, just look at Wikipedia: Oscillococcinum, Anaferon), then let’s look at ergoferon in more detail. You can read his instructions, it is a very entertaining activity.
A small digression. We are talking about homeopathy, which has many active supporters (although it would be more correct to say adherents, or believers). Let's dot the i's:
The scientific community regards homeopathy as a scam, citing the lack of scientific basis for this method of treating diseases. The theoretical basis for the homeopathic principle does not correspond to scientific ideas about the functioning of a healthy and sick body, and clinical trials of homeopathic medicines have not revealed any differences between homeopathic medicines and placebos. Trivial calculations show that drugs in dilutions of 12C and higher most likely do not contain a single molecule of the active substance.
The World Health Organization (WHO) warns against homeopathic treatment of infectious and any other serious diseases. As the organization’s experts note, “the use of homeopathy has no evidence base, and in cases where it is used as an alternative to basic treatment, it poses a real threat to people’s health and lives.”
We read the composition of Ergoferon - everything is beautiful, convincing, and the doses are serious:
active substances:
antibodies to human γ-interferon, affinity purified 0.006 g*
affinity purified antibodies to histamine 0.006 g*
antibodies to CD4 affinity purified 0.006 g*
Everything seems to be fine, but something is confusing. What kind of star is this? And this is a footnote, and below is its transcript, printed, of course, in small, small font. Oh, those footnotes and small print... It's high time to equate such methods with fraud.
* applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted 10012, 10030, 10050 times, respectively.
Stop, stop, stop! That is, if you roughly calculate, it turns out that one molecule of the active substance is contained in one hundred million tablets? In other words, the probability of encountering the active substance in a tablet is less than the probability of being killed by a meteorite! It turns out that for 200-300 rubles you buy only the excipients that make up the tablet: lactose monohydrate, microcrystalline cellulose, magnesium stearate, which do not have any medicinal properties.
Read on. In the description of pharmacological activity, the expression “ components included in the drug", and there is a description about them " It has been experimentally proven that:" Please note: we are talking about the components of the drug (antibodies, which, as we found out, are simply not in it), and not about the drug itself as a whole. Against this background, the phrase “ The combined use of the components of a complex drug is accompanied by an increase in the antiviral activity of its components."looks like a mockery. Yes, I understand that these antibodies have therapeutic efficacy, but how does this relate to your drug?
Well, the most masterpiece:
Pharmacokinetics
The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Ergoferon.
Of course, it is difficult to find a black cat in a dark room if it is not there.
It’s a shame that these obviously unrelated substances are found in pharmacies among medications, and bring their fraudulent creators billions of dollars in profits from gullible Pinocchio buyers.
Click to expand...

http://www.m-sokolov.ru/2014/03/01/ergoferon/
Will a unicorn horn help, or What is Anaferon?
“Make posset with white wine and skim off the foam. Take stallion dung, as warm as possible, and mix it with the drink, add a little Metridate, Carduus Benedictus and unicorn horn, and if there is no unicorn horn, then take ivory or fish tooth and give the patient a drink in the morning on an empty stomach. Repeat the treatment two or three times in a row." (“A Closet for Ladies and Gentlewoman”, 1611)
For a modern person, this recipe for treating fever will only cause a smile and purely historical interest. Nowadays, hardly anyone would risk being treated with warm manure or fish teeth, rightly considering these remedies to be useless. However, is the difference between modern man and our ancestors, who relied on the recipes of medieval healers, really so great?
In the vast majority of cases, fever is a symptom of a cold or flu. And in most cases, the local therapist will prescribe a course of the extremely popular drug Anaferon in Russia as treatment. In 2009, Anaferon's sales volume came close to 1.5 billion rubles. What do patients receive in exchange for this astronomical amount?
Anaferon is the first strange thing. Anaferon appeared on the market in 2002 as a result of research by a pharmaceutical company. By the way, the company itself arose in 1993, when “a group of enthusiastic scientists decided to make their dream come true: to develop and launch affordable and safe homeopathic medicines on the market.” If you still remember that time, then you understand that then it could only be about making money, but not about “intensive scientific research.”
Nevertheless, the company’s specialists were the first in Russia to begin mass production of complex homeopathic medicines, thereby radically distorting the basic principles of homeopathic treatment. A few years later, this became so obvious that it even required changing the instructions for Anaferon.
Here is the current description from the manufacturer's website. Anaferon - lozenges. A drug for the safe treatment and effective prevention of influenza and ARVI. Active components: affinity purified antibodies to human interferon gamma – 0.003 g (administered in the form of an aqueous-alcohol mixture of the active form of the active substance containing no more than 10^-15 ng/g of the active substance). Excipients: lactose, microcrystalline cellulose, magnesium stearate.
But on the Internet you can find another, old, description of “Anaferon”. Homeopathic lozenges. Ingredients: affinity purified antibodies to human interferon gamma - a mixture of homeopathic dilutions C12, C30 and C200, excipients: lactose, microcrystalline cellulose, magnesium stearate.
What's the matter? Why did any mention of the homeopathic properties of the drug disappear from the description? It turns out that in the fall of 2009, after reviewing new data regarding the mechanism of action of the drug, the manufacturer decided that homeopathy was not suitable for Anaferon! That is, for seven years the manufacturer was simply confident in the homeopathic properties of Anaferon, and then - suddenly it was cut off. There is no homeopathy here! But the composition of the tablets and production technology remained the same! They are more difficult and more expensive to change than the content of the description. And why?
Anaferon is the second strange thing. Numerous studies have proven that interferon has antiviral and immunostimulating effects. Likewise, it has been proven that in some cases, when interferon is used, specific antibodies are formed in the body, which reduce the effectiveness of interferon treatment. And this immune response most often forces you to stop using interferon. That is, antibodies to interferon contained (maybe?) in Anaferon can only cause inhibition of the action of endogenous human interferon. To increase the production of one's own interferon, interferon inducers are used, to which Anaferon refers no more than any other consonant word.
Anaferon is the third strangeness. The cost of the drug Anaferon is from 120 to 160 rubles per package of 20 tablets. The high cost of medications is most often explained by the high cost of the initial substance used for their manufacture. Often such a substance is not produced in Russia at all, and transportation and customs clearance costs are added to the price of the substance itself. Unfortunately, this is not the case. The main substance for Anaferon is lactose. Anyone can buy it, whether imported or domestic. The imported price is 70-80 rubles for a small bag weighing 25 kg.
Oh yes! There are also “affinity purified antibodies to human interferon gamma.” The production technology involves immunizing rabbits with recombinant human interferon gamma, after which the desired antibodies are isolated from the rabbit's blood serum on an adsorption column. Need a rabbit farm? Difficult and expensive?
Let's approach this from a different angle. One molecule of precious antibodies has a mass of about 2.5x10^−19 grams, and one tablet contains about 3x10^−27 grams. It is not difficult to calculate that the entire annual production of Anaferon requires only about four molecules! From one rabbit you can extract antibodies for the next couple of million years of production. Our rabbit farm quietly deflated.
And the end result is the sale of milk sugar at a price of 30 thousand rubles per kilogram. The drug business nervously smokes on the sidelines, arms dealers are choking with saliva from envy, the oligarchs of the fuel and energy complex feel like beggars. Almost 1,000,000% (million percent!) profit - and everything is legal!
Anaferon is the fourth strangeness. Why is Anaferon so popular, especially among pediatricians? The answer to this question is also logical.
I will write useful but easy recipes. Well, for example, natrii salicilici 0.5, one powder three times a day... “You can prescribe soda!” – my internal interlocutor responded, clearly mocking. (M. Bulgakov. Notes of a young doctor).
I must say that even the malicious inner voice did not think of prescribing sugar for patients. Nevertheless, Anaferon is an ideal medicine. Its appointment does not threaten the slightest complications, and colds, as you know, go away within a week. With pills, however, seven days in advance.
On the official website of Anaferon, a frightened father asked: “My child ate a whole package of Anaferon, what should I do?” “Don’t do anything, no one has ever died from 3 grams of sugar,” was the meaning of the manufacturer’s response.
A much more interesting question is how did Anaferon get on the list of vital and essential medicines? But the answer to this question lies far beyond medical expediency.
Anaferon is the fifth strangeness. There is not a single imported analogue of a drug that is so beneficial for Russian people. In the 10 years since the appearance of Anaferon, not a single foreign pharmaceutical company has become interested in it. That is, despite the fact that viral diseases occur all over the world, treatment with the highly effective and safe drug Anaferon is accepted only in Russia.
Therefore, the next time you go to the pharmacy for Anaferon, think - is it worth it? Believe me, this drug can be successfully replaced with much more effective and tasty cranberries in sugar. And let Anaferon, as well as other equally “effective” drugs, for example, Artrofoon, Afale, Dietress, Impaze, Proproten-100, Tenoten, Ergoferon, take their rightful place in the section “Curiosities and Misconceptions” of the textbook on the history of medicine.
© Shkolazhizni.ru
Click to expand...

http://shkolazhizni.ru/health/articles/50155/
Anaferon https://health.mail.ru/drug/anaferon/
Ergoferon http://www.24farm.ru/preparats/ergoferon_medika_holding/
Arbidol https://health.mail.ru/drug/arbidol_3/
The composition, for example, of Anaferon includes:
affinity purified antibodies to human interferon gamma (water-alcohol mixture with active substance content not more than 10-15 ng/g)
Click to expand...

If you think about it, it turns out that these antibodies will block our own endogenous IFN gamma, which ultimately pushes the immune system even further and prevents a normal immune response. This is not treatment, but sabotage. But this is only in theory. In fact, there are no antibodies there; the medicine is in fact a dud. This is KHUTZPAh gentlemen.
Add here more information on other well-known pharmaceutical drugs with questionable and unproven effectiveness.
My professor told me about Anaferon: “try it as much as you want, it’s like water.”

Arbidol's action only removes cough (hides symptoms)
My professor told me about Anaferon: “try it as much as you want, it’s like water.”
But maybe not everyone knows about Arbidol, it’s just a story of betrayal of the Russian people, which will be included in textbooks. Type “Madame Arbidol” on the Internet. This is the nickname of the “Minister of Health” Golikova. She partially owns this business and promotes it at the expense of the state. And from it you can easily make a cheap and very dangerous drug (crocodile, it seems). Since Arbidol began to be sold at dumping prices, an epidemic of crocodile drug addiction has spread across Russia. Teenagers who did not have money for drugs can now make them from arbidol. Hundreds, if not thousands of teenagers are literally rotting. Type in the search "crocodile drug photo"
There are people who destroyed a lot of people in Rus'. But you still don’t expect this from the Minister of Health.
Arbidol's action only removes cough (hides symptoms)
Click to expand...

I have friends who are drug addicts, and I have seen the effects of crocodile even after several injections.
Arthrofoon

Dosage form and composition: Lozenges 1 tablet.
active substances:
antibodies to human TNF-α affinity purified* 0.003 g
excipients: lactose monohydrate (lactose) - 0.267 g; MCC - 0.03 g; magnesium stearate - 0.003 g
* applied to lactose monohydrate in the form of a water-alcohol mixture containing no more than 10−15 ng/g of the active form of the active substance
Directions for use and dosage:
Inside, at one time - 2 tablets. (keep in mouth until completely dissolved, not while eating). Take the drug 2 times a day, in the evening and in the morning (before and after sleep).
Rheumatoid arthritis, osteoarthritis (including spondyloarthrosis) and other joint diseases. The recommended duration of taking the drug is up to 6 months. In case of severe pain in the first 2–4 weeks of therapy, it is recommended to take the drug up to 4 times a day, as part of complex therapy. If the condition improves, gradually switch to taking 2 tablets. 2 times a day.
Nonspecific ulcerative colitis. The recommended duration of taking the drug is up to 6 months. In case of severe exacerbation of the disease (abdominal pain, diarrhea), it is recommended to take the drug up to 4 times a day in the first 2–4 weeks of therapy. If the condition improves, gradually switch to taking 2 tablets. 2 times a day.
What do you say, gentlemen? The manufacturer is the same as Ergoferon and the operating principle is the same
Although it is considered a powerful immunostimulant, as far as I read earlier, but here they write that it is comparable to dexamethasone...how can this be the same suppression of the immune system?
Yes, the claw is indeed a stimulant, primarily of phagocytosis. Apparently it somehow regulates the release of TNF, which is produced by macrophages. I don’t really understand this myself, but it’s not immunosuppression for sure.
Fuflomycin!)))
These are all antibodies. Afino purified - complete bullshit!)
These antibodies are not absorbed when taken orally)) they simply cannot be absorbed and act)
Otherwise, Remicade would already be available in tablets)
About the Cat's Claw - interesting information, thank you!)
If the immune system is constantly stimulated, the body’s own cells will be destroyed, and the virus will only thrive on organs that are dilapidated from constant inflammation....
Therefore, it is necessary to switch the immune process....
If the immune system is constantly stimulated, the body’s own cells will be destroyed, and the virus will only thrive on organs that are dilapidated from constant inflammation....
Therefore, it is necessary to switch the immune process....
Click to expand...

where to switch and how?

Active substance

Affinity purified antibodies to human interferon gamma

Release form, composition and packaging

◊ Lozenges from white to almost white, flat-cylindrical in shape, with a notch and a chamfer; on the flat side with a mark there is the inscription MATERIA MEDICA, on the other flat side there is the inscription ANAFERON.

* applied to lactose monohydrate in the form of a water-alcohol mixture containing no more than 10 -15 ng/g of the active form of the active substance.

Excipients: lactose monohydrate - 0.267 g, microcrystalline cellulose - 0.03 g, magnesium stearate - 0.003 g.

20 pcs. - contour cellular packaging (1) - cardboard packs.
20 pcs. - contour cell packaging (2) - cardboard packs.
20 pcs. - contour cell packaging (5) - cardboard packs.

pharmachologic effect

When used prophylactically and therapeutically, the drug has an immunomodulatory and antiviral effect. Experimentally and clinically established effectiveness against influenza viruses, parainfluenza, herpes simplex viruses types 1 and 2 (labial herpes), other herpes viruses (varicella, infectious mononucleosis), enteroviruses, tick-borne encephalitis virus, rotavirus, coronavirus, calicivirus, adenovirus , respiratory syncytial (PC virus). The drug reduces the concentration of the virus in the affected tissues, affects the system of endogenous interferons and associated cytokines, induces the formation of endogenous “early” interferons (IFN α/β) and interferon gamma (IFN γ).

Stimulates the humoral and cellular immune response. Increases the production of antibodies (including secretory IgA), activates the functions of T-effectors, T-helpers (Tx), normalizes their ratio. Increases the functional reserve of Tx and other cells involved in the immune response. It is an inducer of a mixed Tx1- and Th2-type immune response: it increases the production of Th1 (IFN γ, IL-2) and Th2 (IL-4, 10) cytokines, normalizes (modulates) the balance of Th1/Th2 activities. Increases the functional activity of phagocytes and natural killer cells (NK cells). Has antimutagenic properties.

Pharmacokinetics

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of the active components of the drug Anaferon in biological fluids, organs and tissues, which makes it technically impossible to study pharmacokinetics.

Indications

— prevention and treatment of acute respiratory viral infections (including influenza);

- complex therapy of infections caused by herpes viruses (chickenpox, labial herpes, genital herpes);

- complex therapy and prevention of relapses of chronic herpesvirus infection, incl. labial and genital herpes;

— complex therapy and prevention of other acute and chronic viral infections caused by tick-borne encephalitis virus, enterovirus, rotavirus, coronavirus, calicivirus;

— as part of complex therapy of bacterial infections;

- complex therapy of secondary immunodeficiency states of various etiologies, incl. prevention and treatment of complications of viral and bacterial infections.

Contraindications

- increased individual sensitivity to the components of the drug.

The use of the drug is indicated for children and adolescents under 18 years of age.

Dosage

The drug is taken orally, not during meals. The tablet should be kept in the mouth until completely dissolved.

ARVI, influenza, intestinal infections, herpesvirus infections, neuroinfections

On the 1st day take 8 tablets. according to the following scheme: 1 tab. every 30 minutes in the first 2 hours (total 5 tablets in 2 hours), then during the same day take another 1 tablet. 3 times at equal intervals. On the 2nd day and further, take 1 tablet. 3 times a day until complete recovery.

If there is no improvement on the 3rd day of treatment with the drug for acute respiratory viral infections and influenza, you should consult a doctor.

IN epidemic season for preventive purposes The drug is taken daily 1 time/day for 1-3 months.

Genital herpes

At acute manifestations of genital herpes the drug is taken at regular intervals according to the following scheme: 1-3 days - 1 tablet. 8 times/day, then 1 tablet. 4 times/day for at least 3 weeks.

For prevention of relapses of chronic herpes virus infection- 1 tablet/day. The recommended duration of the preventive course is determined individually and can reach 6 months.

When using the drug for treatment and prevention of immunodeficiency conditions, in complex therapy of bacterial infections- take 1 tablet/day.

If necessary, the drug can be combined with other antiviral and symptomatic agents.

Side effects

Allergic reactions and manifestations of increased individual sensitivity to the components of the drug are possible.

Overdose

No cases of overdose have been reported to date. In case of accidental overdose, dyspepsia may occur due to the excipients included in the drug.

Anaferon contains affinity-purified antibodies to human interferon gamma (a combination of homeopathic dilutions C12, C30 and C200). Also, as additional components, the composition includes MCC, lactose, magnesium stearate.

Release form

Anaferon is produced in the form of tablets for sublingual use; there are 20 such tablets in a package.

pharmachologic effect

Wikipedia contains information that this medicine is used to treat and colds. Anaferon tablets are a homeopathic medicine that provides immunomodulatory And antiviral influence on the body.

An immunomodulatory effect is noted, as the humoral and cellular components of the immune system are activated, the level of , interferon is formed (as a rule, it is gamma interferon), the phagocytic activity of Th1 and Th2 cytokines and macrophages increases.

Thanks to these properties, the drug quickly and effectively relieves respiratory manifestations, as well as symptoms that are characteristic of and . The use of the drug reduces the risk of developing superinfection and the addition of a bacterial infection. If Anaferon is combined with drugs that have an anti-inflammatory and antipyretic effect, then the dose of such drugs can be reduced.

Pharmacokinetics and pharmacodynamics

There is no data on the pharmacokinetics and pharmacodynamics of the drug Anaferon for adults.

Indications for use

The following indications for use of the drug are determined:

ARVI And flu ;
prevention of complications of colds and flu;
herpetic and cytomegalovirus infection in chronic form;
treatment and prevention of infections in people with immunodeficiency conditions;
mixed and bacterial infections (as part of complex treatment).

The drug stimulates the immune system, from which the tablets are recommended for use by those who are at increased risk of infection attacks: people with reduced , those who often stay in large groups of people, etc.

Contraindications

The following contraindications for taking this medicine are defined:

intolerance to any component of the tablets;

Side effects

Side effects are rare when taking this medication. Possible effects on the components of the drug.

Anaferon tablets, instructions for use (Method and dosage)

Instructions for use of Anaferon for adults assume that adult patients take one tablet sublingually at a time. Depending on the severity of the disease, this should be done 3 to 6 times a day. You should start taking the drug immediately after the first signs of a cold appear. After the patient’s condition improves, it is recommended to take 1 tablet for 8-10 days.

To prevent flu and colds, it is recommended to take one tablet per day for 1 month. You can practice a repeat course no earlier than 1 month after the last course was completed.

Anaferon for tick bites for the purpose of prevention you need to take 1 tablet. three times a day for 21 days.

Your doctor will tell you how to take pills for adults in each specific case. As a rule, the dosage regimen is as follows: during the first two hours, 1 tablet should be taken every half hour. After 5 tablets have been taken, the next 3 tablets should be taken within the same day at equal intervals.

Overdose

To date, no cases of Anaferon overdose have been recorded.

Interaction

There is no evidence of clinically significant interaction. The drug can be taken with other antiviral, symptomatic and antibacterial drugs.

Terms of sale

You can buy Anaferon without a prescription.

Storage conditions

Protect from moisture, light, keep out of reach of children. Storage temperature – no more than 25° C.

Best before date

You can store the medicine for 3 years.

special instructions

The effect of the medicine will be most effective if you take it at the first symptoms of the disease.

If there is no improvement in your condition after taking the drug within three days, you should consult your doctor.

Evidence that this drug is dangerous, since Anaferon causes cancer, has not been confirmed by doctors. The claim that Anaferon causes cancer of the lymphatic system is absurd; it has been refuted by leading experts.

Anaferon's analogues

Level 4 ATX code matches:

There are no analogues of this drug for the active component. Analogues are usually called drugs that have a similar effect on the body. There are analogues that are cheaper and more expensive, but only a specialist can adequately select the drug. Medicines can be considered analogues , , candles, etc.

Which is better: Anaferon or Ergoferon?

Ergoferon is a drug that has a pronounced antiviral effect, but also demonstrates an antiallergic effect. The active component of the product is antibodies to interferon gamma, as well as antibodies to histamine. At the same time, Anaferon does not have an antiallergic effect.

Which is better: Anaferon or Aflubin?

A drug has an immunomodulatory, anti-inflammatory, antipyretic, detoxification effect. However, it contains other active ingredients. Therefore, you need to choose the optimal remedy individually, taking into account the characteristics of the course of the disease.

For children

Children aged 1 month and older use Anaferon for children.

Anaferon during pregnancy and lactation

There is no data on the effectiveness and safety of use in pregnant women, therefore, treatment with this drug is not practiced during this period, as well as during lactation.

Reviews about Anaferon

Online reviews of Anaferon for adults are often positive, as users consider this homeopathic remedy to be relatively safe, but at the same time an effective antiviral and stimulant. It is mentioned that the drug, if taken correctly, provides high-quality prevention of colds. Reviews from experts also indicate that the medicine is a high-quality immunomodulator.

Anaferon price, where to buy

Price Anaferona And Anaferon for children almost the same. Price may vary depending on location of sale. The price of Anaferon for adults is from 200 rubles for 20 pieces. The price of tablets in Ukraine is on average 80 hryvnia per pack. 20 pcs.

Online pharmacies in Russia Russia
Online pharmacies in Ukraine Ukraine
Online pharmacies in Kazakhstan Kazakhstan

ZdravCity

Anaferon children's drops for internal use. approx. fl. with drip 25ml No.1LLC Materia Medica Holding

Anaferon tablets for rassas. No. 20Materia Medica LLC

Anaferon children's tablets for rassas. No. 20Materia Medica LLC

Pharmacy Dialogue * discount 100 rub. by promo code medside(for orders over 1000 rub.)

Anaferon (drops for internal use for children, 25 ml)

Anaferon lozenges No. 20 for children

Anaferon tablets d/rass. No. 20

Europharm * 4% discount using promo code medside11

Anaferon children's drops for oral administration 25 mlNPF Materia Medica Holding

Anaferon lozenges 20 tabsNPF Materia Medica Holding

Anaferon children's lozenges 20 pcs.Materia-Medica Holding NPF LLC

Pharmacy IFC

Anaferon

Anaferon Materia Medica Holding NPF LLC, Russia

Pharmacy24

Anaferon for children No. 20 tabletsZAT Santonika, Lithuania
Anaferon No. 20 tabletsZAT Santonika, Lithuania

PaniPharmacy

Anaferon children's tablets Anaferon children's tablets No. 20Russia, Materia Medica

Anaferon tablets Anaferon tablets No. 20Russia, Materia Medica

Author-compiler:- pharmacist, medical journalist

Speciality: Pharmacist

Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Experience: From 2003 to 2013, she worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Anaferon, be sure to consult with your doctor.

Tanya | 16:24 | 13.06.2019

Anaferon - Loved! I love and will continue to love))) An excellent antiviral drug, it helped me always and everywhere, despite the fact that sometimes I forgot to take it according to the regimen prescribed by the doctor or started taking it when the disease had already seriously progressed, but it always coped with the task assigned to him.

Anatoly | 20:16 | 15.02.2018

In a word, bullshit

Farida | 21:10 | 30.11.2017

People! Anaferon is an artificial interferon. The human body begins to produce its own interferon on the third day from the onset of the disease. Then there may be no symptoms.

Irina | 13:57 | 21.09.2017

Anaferon is very suitable for ignorant doctors!! They took it and it didn’t help, which means they started taking it too late. They took it and got sick - the virus has mutated and this is a new stamp.

Zhanna | 16:45 | 21.08.2017

Anaferon is homeopathy, although it was registered as medicine. But registration is one thing, but actually working medicine is another. It's high time to remove it from pharmacy shelves so that people don't buy pacifiers!!

Elena | 16:56 | 25.07.2017

I don’t consider Anaferon a medicine and am waiting for it to be removed from the shelves of pharmacies, so as not to deceive people by selling them an ordinary pacifier instead of a medicine.

Marina | 11:13 | 09.06.2017

All these ferons are nonsense, ordinary bullshit, and anaferon is in the same list, I don’t even want to discuss it.

Kira | 12:25 | 25.05.2017

The manufacturer of Anaferon registered his brainchild as a drug, while for their preparation he borrowed the basic principle of homeopathy - repeated dilution, up to the complete absence of the active substance. There is no mention that this is homeopathy...