Human leukocyte interferon ampoules. Human leukocyte interferon: instructions for use

Human leukocyte interferon is a unique product with pronounced immunomodulatory and immunostimulating capabilities. This medicine is able to reduce the growth of tumors, which is achieved due to the presence of interferon alpha in it.

The latter refers to a group of proteins produced by white blood cells in human blood. They help our body fight a large number of diseases of viral, fungal, infectious and other nature.

Indications for use

What helps to cure leukocyte interferon? When used correctly and in a timely manner, it speeds up recovery in the case of the following ailments:

respiratory system infections;
bacterial infections;
immunodeficiency;
viruses;
benign and malignant neoplasms;
kidney and liver diseases;
infections of fungal origin;
pathologies of the mucous membranes and eyes.

Leukocyte interferon is used to prevent these health problems and strengthen the immune system in general.

The drug is included in the complex therapy of many pathologies, and its dosage is prescribed only on an individual basis.

Release forms

Interferon is available in ampoules, in the form of suppositories, ointments and in the form of a dry powder - a lyophilized substance. The latter needs to be diluted with saline solution, while the substance in ampoules is already ready for use.

pharmachologic effect

Human protein, which is interferon, is able to exert its healing effects immediately after entering the body. It inhibits the activity of pathological microorganisms and increases the protective abilities of the body as a whole.

Because of the latter property, a person who has consumed the powder may experience a slight rise in temperature, which is considered an adequate response to an increase in the concentration of interferon in the blood. As you already know, the vast majority of bacteria and viruses die at 37 degrees.

Interferon for children

Interferon ampoules

Inhalations based on human protein are quite effective. For them, you need to dissolve the contents of three ampoules in 10 ml of boiled water and perform irrigation procedures for the oral (nasal) cavity twice a day.

Interferon powder

Having bought the dry form of the drug, the powder in a glass pharmacy container must be diluted with two milliliters of warm boiled water. The interval between instillations is 6 hours, while the general course lasts until the threat of infection with the virus passes.

If human interferon is used for intensive healing, it must be diluted in a similar way (for powdered form), but drip after a couple of hours, again, five drops in each nostril of the child.

Interferon ointment

Interferon in the form of an ointment is a convenient everyday remedy against viruses. It can be used to treat not only the nostrils, but also the tonsils.

Interferon suppositories

As for suppositories, they are often recommended for use in newborns or when the therapeutic effect needs to be achieved as quickly as possible. Once in the rectum, human interferon instantly penetrates the blood and begins its healing effect. It is customary to administer the drug rectally every 12 hours, but not more than five days in a row.

Interferon for adults

Eye pathologies: the powder is diluted with one milliliter of boiled water and buried under the lower eyelid. The procedure must be repeated 10 times a day, while the general course can take two days or a couple of weeks;
Viral, bacterial and colds of the respiratory tract: the powder is diluted in 2 ml of warm boiled water and on the first day of illness, 1-3 drops are administered into each nostril every 2 hours. The interferon is then divided into 5 doses maximum;
Immunodeficiency, as well as the condition of benign and malignant neoplasms, is corrected according to the following scheme: Interferon powder is diluted with saline and injected intramuscularly. If you need to give an intravenous injection, sodium chloride is used for dilution.

Contraindications for use

The instructions for use of the protein categorically do not recommend including the drug in treatment regimens if the following deviations are present:

Personal intolerance to the substance in its pure form;
Increased sensitivity to chicken protein;
Antibiotic intolerance;
Complex organic pathologies;
CNS dysfunctions;
Malfunctions of the liver, thyroid gland or kidneys;
Chronic form of hepatitis;
Cirrhosis of the liver;
Taking sedative medications or immunosuppressants;
Use of strong sleeping pills or opioid analgesics.

Interferon and alcohol

Dry powder is not suitable for use with alcohol.

Alcohol greatly detracts from the positive properties that drugs based on it bring with them, and provokes a large number of side effects in the form of:

vomiting and nausea;
depression;
headaches and dizziness;
rapid heartbeat;
appetite suppressants;
suicidal states;
changes in liver function, etc.

The most interesting thing is that the effect of synthetically produced protein on the human body has not yet been fully studied, and doctors are finding more and more new indications for its use. This leads to a logical conclusion: the consequences of taking the drug in tablets or intramuscularly, supplemented by drinking alcohol, can be completely unpredictable, and it’s good if it all ends in allergies or one-time vomiting.

Viral diseases occur to the average person several times a year. You can fight them in different ways. But the quality of treatment and the speed of recovery depends on the effectiveness of the medications used. One of the best drugs currently available for viral diseases is Interferon.

It should be noted that human leukocyte Interferon is an excellent immunomodulatory, antiviral and antitumor drug. This remedy helps the body's cells organize additional protection against the virus.

IMPORTANT: Interferons are proteins that the body produces when a virus enters it. The drug in question helps to activate the body’s process of producing protective proteins.

In 1957, virologists A. Isaac and D. Lindeman discovered an amazing protective mechanism that turns on in the body's cells at the moment of infection of one of them. This mechanism is “prescribed” at the genetic level. When one of the cells becomes infected with a virus, it produces special protein molecules (interferons). These molecules enter neighboring cells and make them immune to the virus.

Human leukocyte interferon is a protective protein that, when it enters the body, helps the immune system and fights painful viruses.

Release form

The product is available in the form:

Suppositories for rectal use 40,000 IU
Lyophilisate for preparing a solution for nasal instillation 1000 IU
Liquid solution for inhalation and topical use 1000 IU/ml

Indications for use

Interferon is indicated for the treatment of influenza and ARVI. It can help with tick-borne encephalitis and hepatitis C and B. As part of complex treatment, this remedy is prescribed for leukemia, malignant and benign neoplasms.

Drops of this remedy are used to treat viral eye infections: keratitis, keratouveitis and conjunctivitis.

Rectal suppositories of this drug are used for secondary immunodeficiency conditions.

Interferon for children

Drops of this medicine are used for the treatment and prevention of infectious viral diseases in children. This drug can be used from birth
Prepare a solution for instillation into the nose by adding 2 ml of chilled water to an ampoule with this product. The prepared solution should be instilled into each nostril and then massaged into the wings of the nose. This is done to ensure that the solution is distributed correctly.
To prevent ARVI, the solution for children should be instilled 5 drops into each nostril 2 times a day. At least 6 hours should pass between such instillations. For prophylaxis, this drug should be used as long as the risk of infection remains.
If a child has signs of ARVI, you need to start taking Interferon as soon as possible. For 2-3 days you need to instill a solution of 5 drops every 1-2 hours

Interferon dosage

This drug in injection solution is used subcutaneously, intramuscularly and intravenously. The dosage is determined by the attending physician and depends on the age and nature of the disease.
"Interferon" in the form of a powder or ready-made solution can be used as a liquid for inhalation
This remedy can be used for the treatment and prevention of acute respiratory viral infections. To do this, I instill 5 drops of the solution into each nostril. For prophylaxis, 6 hours should pass between instillations. During treatment, this should be done every 1-2 hours
For viral conjunctivitis, the solution is instilled 1-2 drops into each eye 6-8 times a day
In the treatment of acute hepatitis B, this drug is used in the form of suppositories. The dosage should be selected by the doctor based on the individual characteristics of the body. The course of treatment should not exceed 14 days

Interferon in ampoules

Ampoules with this product are the most popular form of Interferon. They are used to prevent viral diseases. To do this, the contents of the ampoule are poured into water to the 2 ml mark. Apply 5 drops of this solution to your nose twice a day.
To treat viral diseases, you need to increase the dosage of this drug. The most intensive treatment is necessary in the first 2-3 days of the disease
You can use Interferon for inhalation. To do this, you need to dilute the contents of the ampoule in 10 ml of warm water.

Interferon contraindications

Do not use the drug for:

Severe heart disease
Impaired kidney and liver function
For chronic hepatitis and cirrhosis of the liver
Autoimmune hepatitis
Epilepsy
Central nervous system disorders
Hypersensitivity to interferon alfa
Thyroid diseases

During pregnancy, this drug is prescribed with great caution. It can be used only if the risk of threat to the fetus is less than the benefit of this remedy for the woman. Interferon can be used only from the twenty-eighth week of pregnancy.

Elderly people can be prescribed this drug. But it must be used extremely carefully. It is necessary to establish special monitoring of such patients.

Interferon or Viferon?

Both drugs contain the same active ingredient. But, unlike Interferon, it contains vitamins and other useful compounds. In addition, “Viferon” in the form of suppositories is easier and more convenient to use to treat a child. It is more convenient to store Viferon. Interferon solution cannot be stored for more than 12 hours.

Analogs

"Alfaferon"

"Gripferon"- an immunomodulating drug (drops and spray) with an antiviral effect based on interferon alpha. Used for the prevention and treatment of viral infections.

Dosage: depends on the disease. Course: prescribed by the attending physician

"Wellferon"— solution for injection based on the active substance interferon alpha. Used to combat viral infections.

Dosage: depends on the disease. Course: prescribed by the attending physician

"Inferon"- a medicine made on the basis of interferon alpha that has an antiviral effect. Used for the prevention and treatment of acute respiratory viral infections, influenza and other diseases.

Dosage: depends on the type of disease. Course: prescribed by the attending physician

"Lokferon"- a medicine made on the basis of interferon alpha with an antiviral effect. Available in the form of a lyophilisate for preparing a solution.

Dosage: depends on the severity of the disease and indications. Course: prescribed by the attending physician

Oleg. Not a bad remedy. I noticed that if you start using it in time at the first signs of the disease, you can quickly get back on your feet. The last two times I recovered in 2-3 days. I advise everyone.

Ilona. Immunomodulators are certainly good, but I would not recommend using them often. Our body is “lazy” and if it sees that someone is working for it, it immediately starts slacking. This also applies to the immune system. Therefore, you need to weigh the pros and cons when taking this medicine. Yes, during a flu epidemic it is still better to use Interferon. But, in all other cases, the body must fight on its own.

Video: What are the differences between immunostimulants?

Composition and release form of the drug

Lyophilisate for the preparation of solution for intranasal administration and inhalations.

1000 IU - ampoules (10) - cardboard packs.
1000 IU - ampoules (5) - cardboard packs.
1000 IU - ampoules (10) - contour blister packs (1) - cardboard packs.
1000 IU - ampoules (10) - general cardboard packs.
1000 IU - ampoules (5) - general cardboard packs.

pharmachologic effect

Interferon alpha is a mixture of different subtypes of natural alpha interferon from human blood leukocytes. It has an immunostimulating and antiproliferative effect. The antiviral effect of the drug is based mainly on increasing the resistance of body cells that have not yet been infected with the virus to possible effects. By binding to specific receptors on the cell surface, interferon alpha changes the properties of the cell membrane, stimulates specific enzymes, affects the RNA of the virus and prevents its replication. The immunomodulatory effect of interferon alpha is associated with stimulating the activity of macrophages and NK (Natural killer) cells, which, in turn, participate in the body’s immune response to tumor cells.

Indications

For parenteral use: hepatitis B and C, genital warts, hairy cell leukemia, multiple myeloma, non-Hodgkin's lymphoma, mycosis fungoides, Kaposi's sarcoma in patients with AIDS who do not have a history of acute infections; renal carcinoma; malignant melanoma.

For rectal use: treatment of acute and chronic viral hepatitis.

For intranasal use: prevention and treatment of influenza, ARVI.

Contraindications

Severe organic heart disease, severe dysfunction of the liver or kidneys; epilepsy and/or dysfunction of the central nervous system; chronic hepatitis and cirrhosis of the liver with symptoms of liver failure; chronic hepatitis in patients receiving or recently receiving treatment (except for treatment with corticosteroids); autoimmune hepatitis; thyroid diseases resistant to traditional therapy; confirmed hypersensitivity to interferon alpha.

Dosage

The dose, frequency and duration of use are determined depending on the indications, severity of the disease, route of administration, and individual patient response.

Side effects

When used parenterally, side effects are observed much more often than with other routes of administration.

Flu-like symptoms: fever, myalgia, weakness.

From the digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely - liver dysfunction.

From the cardiovascular system: arterial hypotension, arrhythmia.

From the side of the central nervous system: drowsiness, impaired consciousness, ataxia.

Dermatological reactions: rarely - slight alopecia, dry skin, erythema,.

Others: general weakness, granulocytopenia.

Drug interactions

Since interferons inhibit oxidative metabolism in the liver, the biotransformation of drugs metabolized by this route may be impaired.

When used simultaneously with ACE inhibitors, synergism with respect to hematotoxicity is possible; c - synergism regarding myelotoxic action; with paracetamol - it is possible to increase the activity of liver enzymes; with theophylline - decreased clearance of theophylline.

special instructions

Use with caution in patients with a history of a recent myocardial infarction, as well as in cases of changes in blood clotting and myelodepression.

For thrombocytopenia with a platelet count of less than 50,000/μl, s.c. should be used.

Patients should receive hydration therapy, especially during the initial period of treatment.

In patients with hepatitis C receiving interferon alfa therapy for systemic use, thyroid dysfunction, expressed in hypo- or hyperthyroidism, is possible. Therefore, before starting a course of treatment, the level of TSH in the blood serum should be determined and treatment should be started only if the TSH level in the blood is normal.

Use interferon alfa with caution simultaneously with hypnotics, sedatives, opioids

Contraindicated in cases of severe liver dysfunction, chronic hepatitis and cirrhosis of the liver with symptoms of liver failure; chronic hepatitis in patients receiving or recently receiving treatment with immunosuppressants (except for treatment with corticosteroids); autoimmune hepatitis.

Use in old age

If CNS side effects develop in elderly patients receiving high doses of interferon alfa, careful evaluation should be performed and treatment should be interrupted if necessary.

For children from the neonatal period (from birth), the drug is administered intranasally (by spraying or instillation). For children from 3 years of age and adults - additionally in the form of inhalation.

Intranasally

The ampoule with the drug is opened immediately before use. Sterile distilled or boiled water cooled to room temperature is added to the ampoule up to the line indicated on the ampoule, corresponding to 2 ml, and gently shaken until the contents are completely dissolved. The dissolved drug is a clear or slightly opalescent liquid, colorless or light yellow to pink. The dissolved drug can be stored at a temperature of 2 to 8 °C for 1 day.

The drug is used by instillation (using a medical pipette or syringe without a needle) or spraying. Spraying is carried out using sprayers of any system or using the supplied spray nozzle.

For prophylaxis, administration of the drug should begin when there is an immediate threat of infection and continue as long as the risk of infection remains. The drug is used intranasally by instilling 5 drops or spraying 0.25 ml into each nasal passage 2 times a day with an interval of at least 6 hours.

For treatment, the drug is used at an early stage of the disease when the first clinical symptoms appear, 0.25 ml (5 drops) intranasally into each nasal passage after 1-2 hours at least 5 times a day. The earlier its use is started, the higher the effectiveness of the drug.

Rules for using the spray nozzle:

Place the needle on the syringe, fill it with the dissolved drug in a volume of 0.25 ml (mark 10 on a scale of 40 units or mark 25 on a scale of 100 units). Remove the needle and tightly attach the spray nozzle. Bring the spray nozzle close to the nasal passage and sharply press the syringe plunger to inject the drug into the nasal passage. Remove the spray nozzle, put on the needle and draw 0.25 ml of the drug from the ampoule into the syringe. Remove the needle, tightly put on the spray nozzle again and inject the drug into the other nasal passage in accordance with point 3.

The spray nozzle is inserted to a depth of 0.5 cm into the nasal passages, previously cleared of mucus. The patient should be in a sitting position with his head slightly thrown back and remain in this position for 1 minute after administration of the drug. One attachment may only be used on one patient.

special instructions

Administration of the drug by injection is strictly prohibited.

Use with caution for persons with allergic diseases.

Use in pediatrics

For children from the neonatal period (from birth), the drug is used by spraying and instillation.

Use during pregnancy andlactation

There are no data on experience in pregnant women. Therefore, the drug is used as prescribed by a doctor, taking into account the ratio of the expected benefit to the mother and the possible risk to the fetus and child.

During lactation, there are no restrictions on the use.

Features of influence influence of the drug on the ability to drive a vehicle and potentially dangerous mechanisms

Does not affect.

Features of the effect of the drug in persons with impaired liver and kidney functionand in gerontological practice

There were no specific features of the use of the drug in persons with impaired liver and kidney function. No features of use in gerontological practice have been identified

Human leukocyte interferon is an immunomodulating drug with antiviral, antitumor and antiproliferative effects.

Release form and composition

Dosage forms of Interferon:

Solution for local and inhalation use 1000 IU/1 ml (2 ml in ampoules, 5 and 10 ampoules in a cardboard box; 2 ml in bottles, 1, 5 or 10 bottles per package; in 5 ml dropper bottles , 1 per package);
Lyophilisate for the preparation of a solution for intranasal and inhalation use 1000 IU (1 dose per ampoule, 5 or 10 ampoules per cardboard box);
Lyophilisate for preparing a solution for intramuscular administration 10,000 IU / 1 dose (in ampoules, 5 or 10 ampoules per box complete with solvent);
Rectal suppositories 40,000 ME (10 per pack).

The active substance of the drug is interferon alfa.

Indications for use

Parenterally Interferon human leukocyte is prescribed for:

Hepatitis B and C;
Multiple myeloma;
Genital warts;
Mycosis fungoides;
Hairy cell leukemia;
Non-Hodgkin's lymphomas;
Malignant melanoma;
Renal carcinoma;
Kaposi's sarcoma in patients with AIDS who do not have a history of acute infections.

Rectally Interferon is used for acute and chronic viral hepatitis.

Intranasal and inhalation drug is prescribed for the prevention and treatment of acute respiratory viral infections and influenza.

Contraindications

Human leukocyte interferon is contraindicated in:

Severe renal/liver dysfunction;
Severe organic heart diseases;
Chronic hepatitis and cirrhosis of the liver with symptoms of liver failure;
Epilepsy and dysfunction of the central nervous system;
Autoimmune hepatitis;
Diseases of the thyroid gland that are not amenable to traditional methods of therapy;
Chronic hepatitis in patients who have recently received or are currently receiving immunosuppressants (except for corticosteroids);
Known hypersensitivity to interferon alfa.

During pregnancy, the drug can be used only if the benefits to the woman outweigh the possible risks to the fetus.

If treatment is necessary during lactation, breastfeeding should be discontinued.

Special observation during the period of use of Interferon is necessary for elderly people, patients with a history of myocardial infarction, as well as for myelodepression and changes in blood clotting.

The drug should be used with caution simultaneously with opioid analgesics, sedatives and hypnotics.

Directions for use and dosage

Doses and duration of treatment, especially with parenteral administration, are determined by the doctor individually for each patient, taking into account the indications, severity of the disease, method of administration and the body’s reaction.

Average daily doses for i / m administration, depending on the indications:

Hairy cell leukemia: 3 million IU for 16-24 weeks, then 3 million IU three times a week;
Cutaneous T-cell lymphoma: the first 3 days - 3 million IU each, the next 3 days - 9 million IU each, from days 7 to 84 - 18 million IU each. With maintenance therapy, the maximum tolerated dose is prescribed, but not more than 18 million IU three times a week;
Kaposi's sarcoma in patients with AIDS: the first 3 days - 3 million IU, the next 3 days - 9 million IU, from 7 to 9 days - 18 million IU, with good tolerance from 10 to 84 days - 36 million .ME With maintenance therapy, the maximum tolerated dose is prescribed, but not more than 36 million IU three times a week;
Renal cell carcinoma: in the case of monotherapy - 36 million IU, in combination with vinblastine - three times a week, 18 million IU. The dose is increased gradually, treatment begins with 3 million IU. The course of treatment is 84 days;
Melanoma: 18 million IU three times a week for 8-12 weeks;
Chronic myeloid leukemia and thrombocytosis in chronic myeloid leukemia: the first 3 days - 3 million IU each, the next 3 days - 6 million IU each, from 7 to 84 days - 9 million IU each. The general course of treatment is 8-12 weeks;
Thrombocytosis in myeloproliferative diseases (except for chronic myeloid leukemia): the first 3 days - 3 million IU, from days 4 to 30 - 6 million IU;
Chronic hepatitis C: for 3 months - 6 million IU three times a week, for another 3 months - 3 million IU three times a week;
Chronic active hepatitis B: 4.5 million IU three times a week. Duration of treatment – 6 months;
Primary and secondary thrombocytosis: 2 million IU 5 times a week for 4-5 weeks. If after 2 weeks the number of platelets does not decrease, the daily dose is increased to 3 million IU, if there is no effect by the end of the third week of treatment - to 6 million IU;
Initial thrombocytopenia (less than 15 G/l): 0.5 million IU;
Transitional phase of chronic granulocytic leukemia and myelofibrosis: 1-3 million IU each;
Multiple myeloma: 1 million IU every other day in combination with corticosteroids and cytostatics. The minimum course of treatment is 2 months.

For acute and chronic viral hepatitis, as a rule, 1 suppository per day is prescribed. The course of treatment is 10 days.

For influenza and ARVI, a solution is prepared from the lyophilisate using distilled or boiled water at room temperature: it is poured directly into the ampoule to the 2 ml mark, then shaken well until the powder is completely dissolved. The contents of the ampoule with the prepared solution are also diluted with 2 ml of water.

To prevent influenza and ARVI, it is recommended to begin using Interferon when a threat of infection appears and continue therapy as long as the risk of infection remains. The drug is instilled into each nasal passage, 5 drops (or sprayed 0.25 ml) twice a day with a minimum interval of 6 hours.

For therapeutic purposes, human leukocyte interferon should be used when the first signs of a “cold” appear. Instill a solution of 5 drops into each nasal passage at least 5 times a day at intervals of 1-2 hours for 2-3 days.

Another effective method of use is inhalation (through the mouth or nose). For one inhalation, the contents of 3 ampoules are dissolved in 10 ml of water, heated slightly (to a maximum temperature of 37 ºC), the procedures are carried out 2 times a day.

Side effects

Possible side effects of human leukocyte interferon:

Flu-like symptoms: weakness, headache, fever, myalgia;
From the side of the central nervous system: ataxia, impaired consciousness, drowsiness, nervousness, depression, sleep disturbances;
From the cardiovascular system: arrhythmia, arterial hypotension;
From the gastrointestinal tract: loss of appetite, heartburn, diarrhea, nausea, vomiting, liver dysfunction;
Dermatological reactions: dry skin, skin rash, slight alopecia, erythema;
From the hematopoietic organs: granulocytopenia;
Other: joint pain, sweating, weight loss, visual disturbances.

Most often, adverse reactions are observed with parenteral use.

special instructions

The earlier the use of Interferon for influenza and ARVI is started, the higher the effectiveness of the drug.

If the platelet count during thrombocytopenia is less than 50 thousand/µl, the drug is administered subcutaneously.

If side effects from the central nervous system develop in elderly people receiving high doses of interferon alfa, additional examination is carried out. In some cases, treatment has to be interrupted.

During the period of use of the drug, it is necessary to ensure sufficient fluid intake into the body, especially at the beginning of treatment, to monitor liver function and the content of blood cells. Patients of childbearing potential are advised to use reliable methods of contraception.

Before treatment for hepatitis C, the level of TSH in the blood serum should be determined; Interferon can be prescribed only if the level is normal.

If flu-like symptoms occur, paracetamol is prescribed.

Interferons inhibit oxidative metabolism in the liver, so the biotransformation of drugs metabolized in this way may be disrupted.

With simultaneous use of the drug with zidovudine, synergism with respect to myelotoxic action is possible, with ACE inhibitors - synergism of hematotoxic action, with theophylline - a decrease in its clearance, with paracetamol - an increase in the activity of liver enzymes.

Analogs

Alfaferon, Wellferon, Interferon alpha-2b human recombinant, Interferon alpha-2 recombinant hydrogel-based ointment, Inferon, Lokferon.

Terms and conditions of storage

Store at 2-10 ºC. Keep away from children!

Shelf life – 2 years. The solution prepared from the lyophilisate can be stored for no more than 2 days in the refrigerator.

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