Fezam taken before or after meals. Phezam - instructions for use of capsules, indications, active substance, side effects, analogues and price

The modern rhythm of life and frequent stress have significantly increased the incidence of various diseases of the nervous system. Cerebrovascular diseases also contribute to these statistics. Therefore, nootropics and drugs that affect cerebral blood flow are among the most popular in the pharmacy chain.

Regardless of the etiological cause of the disease, the mechanism of damage to brain cells is cell hypoxia and disruption of intracellular neuronal metabolism. Traumatic brain injuries, tumors, hypertension, cerebral atherosclerosis, cervical osteochondrosis and many other reasons can negatively affect the tone of cranial vessels and the volume of blood flowing to the brain. Impaired blood supply inevitably leads to a decrease in the delivery of oxygen and glucose to tissues. The result is brain hypoxia and disruption of energy metabolism in cells. The situation is further aggravated by the fact that blood flow in the cerebral vessels directly affects the pressure of the cerebrospinal fluid in the ventricles of the brain and meninges, and increased intracranial pressure leads to additional compression of the intracranial vessels and deterioration in the nutrition of brain cells. Cell resources are exhausted and their death occurs. In this regard, it becomes clear that the main goal of therapy for brain damage is to normalize its blood supply and activate metabolic processes in cells.

For many years, the basis of treatment for neurological pathology was cinnarizine and piracetam. Cinnarizine is a selective blocker of slow calcium channels. A decrease in the flow of calcium ions into the smooth muscle cells of arterioles leads to a decrease in their response to biogenic active substances that have a vasoconstrictor effect (dopamine, vasopressin, norepinephrine, etc.) and to a decrease in the tone of the vascular wall. The unique property of cinnarizine is its effective, but not excessive, vasodilatory effect on cerebral vessels in the absence of a pronounced effect on peripheral blood pressure. In addition, cinnarizine reduces blood viscosity and increases the plasticity of red blood cell membranes, which has a beneficial effect on microcirculation processes. The moderate antihistamine activity of cinnarizine helps to reduce tissue swelling, which, combined with a decrease in the tone of the sympathetic nervous system and a decrease in the excitability of the vestibular apparatus, has the most favorable effect on the patient’s condition.

Piracetam is a classic nootropic. Its main effects are: stimulation of energy and protein metabolism in brain cells, improved glucose utilization, increased cell resistance to hypoxia and interneuronal transmission of nerve impulses in the central nervous system.

Since patients have to take several medications at once for a long time, for the convenience of treatment, a combination drug Phezam ® was developed. each capsule contains 400 mg of piracetam and 25 mg of cinnarizine.

Combining these two active ingredients in one capsule made it possible not only to reduce the number of tablets taken simultaneously, but also had the most favorable effect on the clinical effect of using the drug Phezam ®. cinnarizine reduces the excitability caused by piracetam; substances have a mutually potentiating effect in relation to the blood supply to brain tissue and metabolic processes in cells. This, in turn, reduced the likelihood of side effects. An additional advantage for buyers is the affordable price of the medicine.

The use of Phezam ® helps patients with chronic cerebrovascular accidents maintain a high intellectual level and physical activity, prevent disability and improve the quality of life.

Fezam ® is prescribed to children with delayed intellectual development, asthenic syndrome, problems associated with perinatal encephalopathy or traumatic brain injury. The existing age restriction (the drug is not prescribed to children under 5 years of age) is associated solely with the form of release in the form of capsules: in young children, preference is given to liquid forms of medicines.

Fezam ® helps young and middle-aged people quickly recover from traumatic brain injuries, making it easier to withstand mental stress during a session at the institute or at work. The drug is effective as a prophylactic for frequent headaches, including migraines.

Since 2010, Phezam ® has appeared in pharmacies in new packaging.

The high safety profile of the drug Phezam ® makes it indispensable in geriatric practice. Fezam ® is widely used in the treatment of encephalopathies of various origins, in senile dementia, in the complex treatment of strokes in the recovery period, both hemorrhagic and ischemic. A course of use of the drug 2-3 times a year can increase mental and physical activity in older people and significantly improve their quality of life.

The pharmacist can inform the patient about the drug Phezam ®. being confident in the effectiveness and safety of the proven medicine, and the affordable price and large package containing 60 capsules make it profitable and convenient for customers.

Fezam - instructions for use, analogues, reviews, price

Phezam is a combined drug from the group of nootropics that improve cerebral circulation and, as a result, brain function. The drug is used in the treatment of cerebrovascular disorders (for example, vascular atherosclerosis, cerebrovascular insufficiency), strokes. encephalopathies of various origins (for example, against the background of hypertension, traumatic brain injuries, previous infections, etc.), dementia (dementia) of vascular origin, memory disorders, attention and mental work, as well as labyrinthopathy, Meniere's syndrome and neurological pathology of childhood .

Composition, names and release forms of Phezam

Currently, Phezam is available in a single dosage form - capsules for oral administration. Often these capsules are called tablets, which is incorrect from a scientific point of view, but is quite suitable for designating a dosage form intended for oral administration. However, it should be remembered that when people say “Phesam tablets,” they mean the oral form, that is, capsules. Additionally, there is a common misnomer for the drug, Phezama, which is often used in everyday speech. Therefore, when you hear the term “Phesama”, you should know that we are talking about the drug “Phesam”.

Phezam contains two active components:

1. Cinnarizine – 25 mg;

This means that each capsule contains 400 mg of Piracetam and 25 mg of Cinnarizine. Due to this content of active substances, the drug is often called “Phesam 400 + 25” in the slang of medical workers. When a person sees a similar name, do not be afraid, since we are talking about the same Fezam.

Phezam contains the following substances as auxiliary components:

Lactose;
Colloidal silicon dioxide;
Magnesium stearate.

The capsule shell consists of 98% gelatin and 2% titanium dioxide dye.

Phezam capsules are dense, cylindrical in shape, painted white. Inside the capsules there is a powdery mixture, colored white or cream. The powder inside the capsules may have small lumps, which, when lightly pressed with a dense object (for example, a spoon, glass rod, etc.), crumble and turn into powder. Fezam is available in packs of 60 capsules.

Fezam - mechanisms of action and scope of therapeutic use

The mechanism of action and therapeutic effects of Phezam are determined by the active components included in its composition. The general, resulting therapeutic and clinical property of Phezam is its ability to improve cerebral circulation and metabolism in cells and nerve fibers of the brain. In fact, all other effects of Phezam are due precisely to the activation of blood flow and the intensification of metabolism in brain cells.

Since Phezam is a combination drug that includes two active components, we will consider the properties of each of them and their resulting combined effect.

Piracetam is a nootropic drug that improves brain activity, having a positive effect on metabolic processes. Piracetam increases the rate of glucose consumption. which is the main nutrient for the brain, since from any other compounds the cells of the central nervous system are not able to receive the energy necessary to maintain life and function. That is, brain cells under the influence of Piracetam begin to actively feed, producing more energy, which is quite enough to ensure intensive functioning of the organ. It is thanks to this that the speed of impulse transmission between neurons increases, memory is activated, attention is concentrated and a general improvement in intellectual function occurs.

In addition, Piracetam improves blood supply to various areas of the brain where there is vascular damage and moderate or mild oxygen deprivation (ischemia). Thanks to the improvement of microcirculation in the brain, ischemic areas suffering from oxygen deficiency disappear, and the entire volume of neurons is included in intensive work. Improving blood flow is achieved not only through direct effects, but also indirectly, which consists in inhibiting platelet aggregation and, therefore, preventing the formation of blood clots. Thus, Piracetam improves not only blood circulation, but also the properties of blood, making it most suitable for circulation through microvessels. In areas of the brain susceptible to ischemia, Piracetam has a protective effect, increasing the resistance of neurons to hypoxia and death.

That is, Piracetam is able not only to improve cerebral circulation, but also to enhance the integrative function of the brain (the ability to synthesize and analyze, generalize, non-standard solutions, etc.), increase the productivity of intellectual work, consolidate memory, facilitate the learning process and assimilation of new material , as well as restore and maintain brain function in older people.

Cinnarizine is a substance that has a pronounced effect directly on the blood vessels of the brain. Thus, cinnarizine dilates the blood vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances that constrict blood vessels. Cinnarizine dilates blood vessels, due to which blood flow is activated, and the supply of oxygen and nutrients to various parts of the brain is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissue to lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and blood pressure.

Together, Cinnarizine and Piracetam enhance each other's effects, so the severity of the resulting effect of Phezam is higher compared to using the drugs in isolation, separated by time of administration. However, in Phezam the sedative effect of Cinnarizine predominates, due to which a person does not feel psychomotor agitation, as when using Piracetam.

Phezam - indications for use (what Phezam tablets are for)

Currently, Phezam is indicated for use in the treatment of various diseases and conditions associated with cerebrovascular accidents and injuries. as well as disorders of integrative function. However, not all of these conditions are included in the list of official indications for the use of the drug, since their effectiveness has not been scientifically proven. Therefore, we provide only a list of approved, official indications for the use of Phezam.

So, the indications for the use of Phezam are the treatment of the following diseases or conditions:

Impaired thinking function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or think about a situation from different points of view, etc.);
Poor concentration;
Mood disorders;
Intoxication of any origin;
Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
Encephalopathy of various origins (against the background of chronic hypertension, traumatic brain injury, infection, surgery, anesthesia, etc.);
Dementia (dementia) caused by vascular pathology;
Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
Labyrinthopathy (pathology of the structures of the inner ear), manifested by tinnitus. nausea, vomiting, nystagmus. motion sickness;
Meniere's syndrome;
Aphasia (speech impairment) caused by vascular pathology;
Prevention of kinetosis (motion sickness, seasickness, etc.);
Migraine prevention;
Mild neurological pathology in children (poor learning ability, low concentration, insufficient long-term memory, etc.);
In a comprehensive methodology for teaching children who have mental retardation.

Phezam (tablets) – instructions for use

Phezam capsules must be taken orally, swallowed whole, without chewing, without breaking the integrity of the shell, and without pouring the powder into a glass of water. The capsule should be taken with a small amount of water (at least half a glass) or any other liquid with the exception of carbonated sweet drinks, coffee and caffeine-containing energy drinks. For example, you can take Phezam capsules with mineral water. juice, tea, compote, fruit drink and other drinks. The only condition that liquid for drinking Phezam must satisfy is a low temperature, that is, the drink should not be hot, but warm or cool.

Phezam capsules can be taken at any convenient time, regardless of meals. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after meals. Moreover, a light snack, for example, an apple, is quite suitable as a meal. banana or other fruit, sandwich, piece of meat, etc.

You should always try to take Phezam capsules at the same time, for example, every day at 9-00 am, or every day at 8-00 and 18-00, depending on how many times a day it is recommended to take the drug. Moreover, if a person missed a dose at the prescribed time, then he should take the capsule immediately, if the next period for taking Phezam has not arrived. If, after missing a capsule, it is time to take the next one, then you should take only one, not two, without trying to compensate for the forgotten dose of the drug.

To treat various diseases, adults should take Phezam 1 to 2 capsules three times a day for one to three months. Children over 5 but under 18 years of age should also take Phezam 1–2 capsules for the treatment of various diseases and conditions, but only once or twice a day for 1.5–3 months. The duration of therapy is determined by the severity of the disease and the rate of clinical improvement. You should not take Phezam for more than three months without a break. If necessary, courses of treatment can be repeated 2–3 times within one calendar year.

Phezam overdose

An overdose of Phezam during the entire period of use of the drug was recorded a very limited number of times. The drug is safe, and even exceeding the therapeutic dosage several times did not cause significant side effects that would force a person to stop taking Phezam. The only symptom of Phezam overdose in adults may be abdominal pain. which, as a rule, is well tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations or convulsions.

If any symptoms of overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at relieving discomfort. In addition, it is recommended to perform gastric lavage. An overdose of Phezam can also be treated with hemodialysis.

Special instructions for the use of Phezam

Athletes should stop taking the drug 2 to 3 days before doping tests, since the cinnarizine contained in Fezam can give a positive test result.

In addition, the use of Phezam may give a false-positive test result for the determination of radioactive iodine. since the capsule dye contains this microelement. Fezam also activates the thyroid gland. as a result, a person may experience tremor (shaking) of various parts of the body and anxiety.

If Piracetam causes insomnia and tension in a person, then it should be replaced with Phezam, which in such situations is the optimal drug. Fezam is also the drug of choice if doctors have simultaneously prescribed Cinnarizine and Piracetam (this may be prescribed by different doctors).

While using Phezam, you should be careful when working with various mechanisms, including when driving a car, since cinnarizine may cause drowsiness in the initial stages of therapy.

While taking Phezam, you should refrain from drinking alcohol, as this will provoke massive death of brain cells.

When using Phezam in people suffering from liver diseases. transaminase activity (AST, ALT) should be monitored once a week. If transaminase activity increases by more than 1.5 times the upper limit of normal, Phezam should be discontinued.

If a person has kidney disease, before prescribing Phezam, creatinine clearance should be determined using the Rehberg test. If creatinine clearance is more than 60 ml/min, then Fezam can be taken in the usual dosage, monitoring this laboratory indicator every 3 to 4 days. If creatinine clearance was initially less than 60 ml/min or fell during the use of the drug, then the dosage of Phezam should be halved and the intervals between doses increased.

Use during pregnancy and lactation

Experiments on animals revealed the absence of any negative effects of Phezam on the growth and development of the fetus. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in a woman’s mental state and increased anxiety. lability of the emotional sphere and mood, which theoretically can have a negative impact on the course of pregnancy.

Because Phezam passes into milk. it is also contraindicated during breastfeeding. If a woman breastfeeding a child must take Phezam for some reason, then the baby should be switched to artificial formula.

Interaction with other drugs

Phezam, when taken simultaneously, enhances the effect of sedatives, other nootropics, antihypertensive drugs and alcoholic beverages. Moreover, Phezam only enhances the inhibitory effect on the central nervous system of all of the listed groups of drugs.

Taking drugs that dilate blood vessels and lower blood pressure. causes all Phezam effects to be enhanced. Accordingly, drugs that constrict blood vessels and increase blood pressure, on the contrary, weaken the effects of Phezam.

Fezam improves the subjective tolerability of drugs from the group of neuroleptics and antidepressants.

Phezam: before or after meals - how to take

Many instructions for use of Phezam, which are available on the package inserts, do not indicate how to take the drug in relation to meals. Usually, if it is not specifically stated how to take the drug - before, during or after meals, this means that it can be used regardless of food, at any convenient time. This rule is also true for Phezam, which can indeed be taken regardless of food intake at any time convenient for a person.

However, experienced doctors or people who have used this drug repeatedly recommend taking it half an hour after meals. They selected this option as the optimal one empirically when they tried different ways of taking Phezam - during, before or after meals. The empirical conclusion that it is best to take Phezam half an hour after a meal is based on the fact that it is with this option that side effects are least likely to develop, and the drug is well tolerated.

If Fezam needs to be taken several times a day, and full meals are impossible for some reason, then you can simply have a snack, for example, an apple, banana, nuts, a bun, a sandwich, etc. instead of lunch, afternoon tea or dinner. A small amount of food entering the stomach can completely replace a full meal in terms of minimizing the discomfort from using Phezam. Remember that the phrase “after eating” does not necessarily mean eating what you consider a complete lunch, dinner, breakfast or afternoon snack. It only means that before taking the medicine you need to eat something, for example, a piece of bread, a piece of fruit, a sandwich, a piece of jelly or cold meat from soup, etc.

Fez for children

Phezam is used for therapy in children older than 5 years of age. If necessary, the use of Phezam in children from one year is allowed.

Fezam in children and adolescents normalizes sleep, eliminates nightmares, stops night awakenings, and reduces fatigue. increases performance, both mental and physical, and also relieves irritability. emotional instability, mood lability and excessive vulnerability. In addition, Fezam reduces the frequency of headaches in children, improves adaptation in school or preschool groups, stabilizes and maintains normal blood pressure, preventing its fluctuations. In general, Fezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Fezam is used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist. and not a psychiatrist, since it is not suitable for the treatment of severe mental illnesses, but can be successfully used to eliminate mild disorders.

After a course of use, the child becomes balanced, less whiny, focused, attentive, he does not get upset so quickly and easily, his mood does not change several times within one minute, he sleeps much more peacefully at night, and mastering speech and other skills occurs more successfully and faster . Such positive changes, combined with good tolerability of the drug, allow doctors and parents to consider Fezam an effective drug and use it to improve mental functioning and development of children.

In addition, Fezam is successfully used in children for the treatment of perinatal lesions of the central nervous system, recovery from traumatic brain injuries and past infectious diseases. In such situations, the drug normalizes brain function, reduces headaches, stabilizes night sleep, and also improves adaptation in a team and learning ability. Phezam can also improve the condition and promote the recovery of children with autism and mild neurological disorders.

Fezam - side effects

Fezam is generally well tolerated and rarely causes side effects. According to international standards, all side effects are classified into several groups depending on the frequency of their occurrence. Regarding Fezam, it was found that all side effects are recorded either sometimes or rarely. Moreover, “sometimes,” according to the international classification, means that the effect develops in less than one person in a hundred, but more than 1 in 1000. And “rarely” means that the side effect develops in more than 1 person in 10,000 , but less than 1 in 1000. All side effects of Phezam are transient, that is, they disappear on their own after stopping the medication and do not require any special treatment.

The side effects of Phezam include the following symptoms from various organs and systems:

1. From the central nervous system:

Hyperkinesis (twitching of limbs, excessive movements, etc.);
Nervousness;
Drowsiness;
Depression;
Dizziness;
Headache;
Ataxia (impaired coordination of movements);
Balance imbalance;
Insomnia;
Confusion;
Excitation;
Anxiety;
Hallucinations.

2. From the gastrointestinal tract:

Disinhibition of sexual behavior;
Increased sexual desire;
Increase in body weight;
Tremor of the limbs;
Increased muscle tone.

Contraindications to the use of Phezam

There are relative and absolute contraindications to the use of Phezam. Absolute conditions are conditions in which the drug cannot be used under any circumstances. Relative contraindications are those in which the drug can be used with caution and under the supervision of a physician.

The following diseases and conditions are absolute contraindications to the use of Phezam:

Severe renal failure. in which creatinine clearance is less than 20 ml/min;
severe liver failure;
Psychomotor agitation present at the time of prescription;
Huntington's chorea;
Acute hemorrhagic stroke;
Pregnancy;
Breast-feeding;
Age under 5 years;
Sensitivity or individual intolerance to the components of the drug.

Relative contraindications to the use of Phezam are the following conditions or diseases:

Fezam - analogues

Currently, there are analogues and synonyms of Phezam on the pharmaceutical markets of Russia and the countries of the former USSR. Synonyms are drugs that contain exactly the same active substances as Phezam. Analogues are considered drugs containing different active substances (not the same as in Phezam), but having similar therapeutic and pharmacological effects.

Today the following drugs synonymous with Phezam are on sale:

Combitropil capsules;
NooCam capsules;
Omaron tablets;
Pyracesin capsules.

The following drugs are analogues of Phezam:

1. Acefen tablets;

2. Bravinton concentrate;

3. Vero-Vinpocetine tablets;

6. Vinpocetine forte tablets;

26. Nooclerin solution;

27. Noopept tablets;

28. Nootropil capsules, tablets and solution;

29. Omaron tablets;

30. Pantogam syrup and tablets;

31. Pantocalcin tablets;

32. Picamilon tablets and solution;

33. Piracezin capsules;

39. Celestab capsules;

40. Cellex solution;

41. Ceraxon solution;

42. Cerebrolysate solution;

44. Encephabol tablets and suspension;

45. Epithalamin powder;

46. Escotropil solution.

Instructions for use of the drug Phezam: pharmacological action, indications, route of administration and doses, side effects, contraindications, analogues - video

Fezam (tablets) – reviews

Reviews about Phezam vary, with approximately 60% positive and 40% negative. Positive reviews are due to a visible clinical improvement in a person’s condition, normalization of memory, attention and increased mental performance, which were observed after a course of use. Also, positive reviews about Phezam are associated with its ability to reduce stress and anxiety during any stressful moments in life, for example, passing exams, interviews for a good job, etc. In addition, people note as a positive effect of Phezam its ability to relieve dizziness and headaches caused by vascular pathology. In such cases, people take Phezam not as a course, but periodically as needed, as a remedy, for example, for headaches.

In some people, Fezam causes irresistible drowsiness, which forces them to take the drug only in the evening or after work. However, someone is willing to tolerate this minus of the drug, generally considering it good due to other positive effects, and, accordingly, leaving a positive review. But other people cannot tolerate this property of the drug, as a result of which they are forced to refuse to take it, and therefore leave a negative review about Phezam.

In addition, negative reviews about Phezam are due to the lack of the expected effect and unpleasant side effects that forced people to stop taking the drug. Also, people leave negative reviews when a slight improvement develops, which does not significantly change the general condition of the person.

Reviews from doctors

Reviews from doctors about Phezam are usually positive, which is due to the effectiveness of the drug in many people, as well as the fact that it can replace several medications. In addition, the positive opinion of doctors is due to the rare side effects that occur when using Phezam, which allows you to be calm about the patient’s condition and not adjust the dosage for a long time. Another important advantage of the drug is its low cost, at which almost all patients can purchase it.

Negative reviews from doctors about Phezam are, as a rule, not due to clinical observations and experience, but to the lack of scientific evidence of its effectiveness. Based on the fact that the clinical effects of the drug have not been scientifically proven, some doctors a priori consider Phezam not a medicine, but a “dummy”, and leave exclusively negative reviews about it.

However, such categoricalness does not always reflect the truth, since even a drug with unproven effectiveness can have a pronounced therapeutic effect in many people, subjectively improving their condition. And even such an effect cannot be called useless, because a person’s well-being improves and the quality of life, accordingly, also improves. Of course, Fezam may not cure serious illnesses, but it can help eliminate mild disorders and painful symptoms.

What's better than Phezam?

In medical science and practice, the term “best” is not used, since each person is individual, and it is impossible to predict all possible effects from the interaction of the body with a chemical compound, and therefore it is simply impossible to single out a drug that is equally good for everyone. Doctors and scientists, instead of the concept “best,” use the term “optimal,” the meaning of which is that this particular drug in this particular situation is the best for a person. All this is true for Fezam.

Therefore, if Phezam is not suitable for a person, or he wants to get a better effect, then he should look for another drug with similar properties among analogues. And the one that satisfies all wishes will be “better than Fezam.”

Phezam - price

Since Fezam is produced by domestic pharmaceutical factories, its cost is relatively low. And differences in cost in retail sales are due to the selling price, transportation and storage costs, as well as the trade markup of a particular pharmacy chain. In principle, the technology for producing the drug is the same and is used in all pharmaceutical enterprises, so there is no difference between a more expensive and a cheaper drug. Because of this, you can safely buy the drug at the lowest price offered. Currently, Phezam is sold in pharmacies in Russian cities at prices ranging from 170 to 238 rubles per pack of 60 capsules.

Where can I buy?

Currently, Phezam is officially sold by prescription, so the drug can only be purchased at a regular pharmacy. However, pharmacists often sell the drug without a prescription or only on the basis of an entry in a person’s medical record. But such luck may not be permanent, so if you need to buy Phezam, it is better to consult a doctor for a prescription.

When purchasing, you should pay attention to the shelf life of the drug, which is 3 years from the date of production. Phezam must be stored in a dark place at an air temperature no higher than 25 o C. Violation of storage conditions leads to loss of active properties, which weakens the therapeutic effect of Phezam.

Before use, you should consult a specialist.

heal-cardio.ru

Fezam

Phezam is a nootropic and psychostimulating drug based on the active ingredients Cinnarizine and Piracetam. The medicine is widely used to normalize blood flow in the brain and activate mental processes in various pathologies. The instructions for use presented in this article contain all the information on the rational use of the product. Data on prices, Russian and foreign analogues of Phezam (substitutes), reviews of patients and doctors will allow patients to choose the most suitable drug.

Compound

The active substances in the drug Phezam (international name Phezam) are:

Cinnarizine - 25 mg per dose.
Piracetam - 400 mg per dose.

Other Ingredients:

gelatin;
lactose;
titanium oxides;
silicon oxides;
magnesium salts.

Phezam is produced in the form of hard capsules, cylindrical in shape (for internal use), painted white. The manufacturer Balkanfarma produces a medical product of 20 or 60 capsules in one package, which contains the official version of the annotation approved in Russia (instructions for use).

pharmachologic effect

The combined medicine Phezam belongs to the pharmacological group of psychostimulants and nootropic drugs. Different mechanisms of action of the ingredients of the product provide the following pharmacological actions:

improvement of cognitive functions;
activation of metabolism in the brain;
stimulation of the propagation of nerve impulses in neurons;
acceleration of blood flow due to improved blood viscosity;
improving the connections between the hemispheres of the brain;
blocking calcium channels;
antihistamine effect (insignificantly expressed) due to Cinnarizine contained in the drug;
reducing the vasoconstrictor effect of serotonins and epinephrines;
increasing the resistance of nervous tissues to oxygen deficiency;
prevention of dizziness attacks.

The drug is quickly absorbed and excreted primarily in the urine.

Indications for use

The manufacturer, based on descriptions of drug studies, has approved the following indications for use:

circulatory failure in the brain;
impaired blood flow in the brain due to a stroke;
cerebroasthenia, which develops as a result of various brain injuries;
encephalopathy;
syndromes accompanied by impaired attention, thinking, memory, and learning abilities;
labyrinthopathy, which is characterized by dizziness, attacks of nausea, tinnitus, frequent vomiting;
prevention of motion sickness and seasickness;
Meniere's syndromes.

Among the contraindications for use, the manufacturer identifies a number of diseases and conditions:

allergy to the ingredients of the medicine;
insufficiency of functioning of the kidneys, especially in severe forms;
disturbances of blood flow in the brain in acute forms;
Parkinson's disease;
chorea;
porphyria;
different types of psychomotor agitation;
childhood. Fezam is not prescribed to children under 16 years of age;
increased intraocular pressure;
pregnancy;
feeding the baby with breast milk. Fezam is not used by women who are breastfeeding during postpartum lactation.

Adults use Phezam (nootropic) only orally after meals. It is important to take the drug with at least 100 ml of water.

Dosage regimen: 1-2 capsules three times a day - before lunch (morning), lunch and evening (after lunch). Duration of treatment is from 1 to 3 months (taking into account the patient’s condition).

Important! It is prohibited to repeat more than three courses of treatment in a row.

It is allowed to carry out 2 or 3 courses of taking the drug throughout the year in compliance with the method of use specified in the instructions.

Overdose

The most common consequences of a drug overdose are the following symptoms (according to information in the Vidal reference book):

dyspepsia (pain in the abdomen, vomiting, diarrhea with blood);
disturbances of consciousness;
drowsiness;
hypotension (low blood pressure);
anxiety;
sleep disorders;
trembling of limbs;
nightmares;
convulsions.

The most effective assistance measures are the following:

gastric lavage;
taking sorbents (Activated carbon);
hemodialysis;
symptomatic treatment.

Side effects are more likely to develop with prolonged use of the drug. The most likely adverse reactions to Phezam are as follows:

allergy;
disturbances of orientation in space;
trembling of limbs;
headache;
stomach ache;
increased fatigue;
bile stagnation;
skin rashes;
depressive states;
increased sweating;
weight gain;
diarrhea.

Important! To prevent side effects of the drug, you should adhere to the prescribed doses.

Phezam enhances the effect of such agents:

Thyroid hormones.
Antidepressants.
Nootropic drugs.
Vasodilators.
Hypotensive.
Anticoagulants.

Taking Phezam does not significantly affect the effectiveness of other medications.

During pregnancy and lactation

Fezam is not prescribed during breastfeeding and pregnancy. It has been proven that the drug is characterized by rapid penetration through the placenta and into breast milk, which can have a negative effect on the condition of the fetus and newborn child.

With alcohol

If Phezam interacts with alcohol, the sedative effect of ethanol increases. It is important to exclude the combination of Phezam and alcohol during treatment due to poor compatibility.

Analogues

The following analogues (synonyms) of Phezam in Russia are presented on the market:

Memozam;
Noosam;
Evryzam;
Omaron - domestic analogue of Phezam (Russian);
Neuro-Norm;
Cinatropil;
Cysam;
Fescetam.

Important! The combination of Piracetam with other nootropic drugs (Cinnarizine, etc.) is more effective for many diseases than single-component drugs.

products containing Citicoline - Kvanil, Somazina, Neuroxon, Somazina;
Aminalon;
preparations containing Piracetam - Lucetam (tablets), Nootropil, Piracetam;
products containing Phenibut - Noofen, Bifren, Phenibut;
medicines containing Vinpocetine - Vinpocetine, Neurovin, Cavinton;
Glycine;
products containing hopantenic acid - Pantocalcin, Cognum;
Betaserc;
Noopept;
combined drugs - Ceregin, Olatropil, Thiocetam;
Picamilon;
Cortexin;
Pramistar;
Phenotropil;
Cerebrolysin;
Mexidol. Phezam in severe cases can be combined with Mexidol at the discretion of the doctor;
Mexico;
Cerepro;
Encephabol.

Important! Lists of analogues, including cheaper ones, are quite large. Fezam can be replaced with other products only on the recommendation of the attending physician.

Phezam is stored for three years from the date of production. After the expiration date, the medicine should not be taken.

Terms of sale and storage

Fezam is sold in pharmacies with prescriptions written by doctors in Latin. The prescription form must indicate the INN of the active substances or the name of the drug in Latin.

Fezam is stored at a temperature not exceeding 25⁰C in dry, well-ventilated areas away from direct light and children (parents should be especially careful).

special instructions

It is important to adjust the dose of the drug in patients who suffer from kidney disease. For them, it is necessary to reduce the dosage or increase the intervals between Phezam doses.

During the treatment of patients with liver pathologies with the drug, the level of liver enzymes should be regularly examined.

Fezam should be used with caution by persons suffering from an increased tendency to hemorrhage, bleeding, or stroke. The dose should be adjusted in patients who regularly or temporarily take anticoagulants. The use of the drug should be avoided in patients with lactase deficiency.

You should be careful when driving a car during treatment with the drug, as dizziness and vestibular disorders may occur.

Price

The cost of Phezam No. 60 differs in different regions of the country. One package of Phezam costs from 300 rubles.

Phezam capsules contain two active components - piracetam And cinnarizine .

The product contains additional ingredients: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

The capsule shell consists of gelatin and titanium dioxide.

Release form

The drug Phezam is produced in the form of cylindrical, gelatin, hard capsules, size No. 0. The capsules are white, inside there is a powdery mixture that is white or almost white. The contents inside may contain conglomerates that turn into powder if you press on them.

Contained in blisters of 10 pieces, blisters are placed in cardboard packs.

pharmachologic effect

The abstract indicates that Phezam is a combined agent that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in cerebral vascular resistance, improving blood flow in these vessels.

As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that are part of the drug Phezam. The main effect observed after taking the medicine is improvement blood circulation in the brain and metabolic processes in nerve fibers and brain cells.

Substance piracetam has a nootropic effect, activating brain activity, positively influencing metabolism in the body. Under the influence of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active nutrition of cells occurs, which leads to the production of more energy and activation of brain function. Piracetam helps increase the speed of impulse transmission between neurons. As a result, memory increases, concentration improves, which leads to increased intellectual function.

Piracetam also helps improve blood flow in those areas of the brain where there are damaged vessels, and is also noted , that is, oxygen starvation. Since microcirculation improves, ischemic zones that arise due to lack of oxygen disappear, and the entire volume of neurons participates in brain function.

In addition, there is an indirect effect of this component, which helps to activate blood flow. It is ensured by inhibiting the process of platelet adhesion, which essentially prevents the formation of blood clots. That is, the piracetam component not only activates blood flow, but also improves its properties. Thus, blood circulates more actively through microvessels.

Under the influence of piracetam, the resistance of neurons to . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and ensures restoration and support of brain functions in older people.

Substance cinnarizine has a pronounced effect directly on the blood vessels of the brain, expanding them. Also, under the influence of this substance, the tone of smooth muscles decreases, their response to active substances that constrict blood vessels decreases. Due to the fact that the substance dilates blood vessels, blood flow is activated, and more oxygen and nutrients enter the brain. Due to improved blood flow, the resistance of brain tissue to oxygen deficiency also increases. At the same time, despite the vasodilating effect, cinnarizine does not affect the parameters of arterial and .

The presence of these two components in Phezam simultaneously ensures a mutual enhancement of the effects of the active components. Consequently, the severity of the effect of the drug is more pronounced compared to taking these components separately.

When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the medicine does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.

Pharmacokinetics and pharmacodynamics

After the patient has taken Phezam tablets orally, the active substances are completely absorbed from the gastrointestinal tract.

The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The bioavailability level of piracetam is 100%.

Piracetam does not bind to plasma proteins, cinnarizine binds 91%. Penetrates the BBB, is detected in all tissues and organs, and passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.

The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.

The half-life of piracetam is 4-5 hours (from the blood), 8.5 hours (from the cerebrospinal fluid). Mainly excreted through the kidneys.

The half-life of cinnarizine is 4 hours. Metabolites are excreted mostly in the urine and also in feces.

In people with renal failure, the half-life of piracetam is increased.

Indications for use of Phezam

Before using the medicine Phezam, the indications for use should be taken into account. The drug is prescribed in the following cases:

with insufficient blood flow in the brain (in case of vessels, during the recovery period after suffering ischemic or hemorrhagic , with encephalopathy of various origins, after a TBI);
when intoxication ;
in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, deterioration of attention, memory, mood;
with psychoorganic syndrome, in which the symptoms predominate asthenia And adynamia ;
consequences of traumatic brain injury;
labyrinthopathy (tinnitus, dizziness, nausea and vomiting);
asthenic syndrome associated with psychogenic origin;
Meniere's syndrome ;
for the purpose of prevention , kinetoses ;
in the complex therapy of children who have a psychoorganic syndrome, which has led to low learning ability.

Contraindications

Phezam should not be taken in the following cases:

in severe forms of renal and liver failure;
during periods of increased psychomotor agitation;
at Huntington's chorea ;
during pregnancy and breastfeeding;
when the patient is under 5 years of age;
with high sensitivity to the components of the product.

The medicine is prescribed with caution to those patients who have been diagnosed , violations hemostasis , liver or kidney dysfunction, severe.

Side effects of Phezam

The following side effects are possible during treatment:

nervous system: nervousness, feeling of drowsiness, hyperkinesia; in rare cases - headaches, , , ataxia , excitement, anxiety;
allergic manifestations: in rare cases - skin rash, , swelling, itching, photosensitivity.
digestive system: heavy salivation, nausea, vomiting, abdominal pain, ;
other manifestations: increased libido.

Phezam tablets, instructions for use (Method and dosage)

The instructions for using Phezam, which are provided in the annotation for the drug, indicate that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years old are advised to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. Capsules should be taken by swallowing them whole, without violating the integrity of the capsule. You should take the tablet with half a glass of water, and it should not be hot.

Many users ask about capsules, how to take them - before or after meals. The instructions say that there is no particular difference in whether to take the product before or after meals. But it is optimal to drink capsules 20-30 minutes after eating. It is advisable to take the medicine at the same time every day.

Doctors warn that you cannot take the medicine for longer than 3 months - a break is necessary between courses.

Overdose

As a rule, Phezam is well tolerated by patients and when taking large doses of the drug, no significant side effects are observed, which requires discontinuation of treatment. In case of overdose, patients may experience abdominal pain. If you take too large doses of the medicine, you need to rinse your stomach and induce vomiting. If there is such a need, perform hemodialysis and symptomatic treatment. There is no specific antidote.

Interaction

Not all medications can be taken with Phezam tablets at the same time, so the interaction of this medication with other medications should be taken into account.

When taken simultaneously with Phezam, drugs that depress the action of the central nervous system, ethanol, tricyclic antidepressants, their sedative effect may increase.

When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.

Vasodilator medications enhance the effect of Phezam.

Due to the presence of cinnarizine in the composition of the drug, the activity of hypertensive medications .

When taking Phezam simultaneously, there is an increase in the activity of thyroid hormones, which can lead to tremor and anxiety.

Due to the antihistamine effect, cinnarizine can mask the manifestation of positive reactions in relation to factors of skin reactivity during skin tests. To avoid this effect, you must stop using the medication 4 days before such tests.

Phezam may enhance the effect of oral anticoagulants.

Terms of sale

You can buy Phezam capsules with a doctor's prescription.

Storage conditions

The medicine should be stored at temperatures up to 25°C, in a dark place. Keep out of reach of children.

Best before date

The shelf life of the capsules is 3 years.

special instructions

If Phezam is prescribed to patients who have impaired liver function, it is necessary to monitor the content of liver enzymes.

The drug activates the functions of thyroid hormones, which is why patients undergoing treatment may experience a feeling of anxiety and tremor.

Since cinnarizine can provoke drowsiness, during the period of treatment you need to drive carefully and work with precise and dangerous mechanisms.

In the treatment of elderly people, it is necessary to regularly monitor the indicators of kidney function and, if necessary, adjust the dose.

Active components are able to penetrate through the filter membranes of devices for .

You should avoid taking the medicine if porphyria .

When taking Phezam, a false positive result may occur during doping control among athletes, also due to the presence of iodine-containing dyes in the capsule shell, there may be a false positive result in the test for the determination of radioactive iodine.

Since piracetam reduces aggregation platelets , it is necessary to carefully prescribe it in violation of hemostasis in patients, as well as in conditions accompanied by hemorrhages. You should not take medicine for complex surgical operations, with severe bleeding and hemorrhagic strokes in history.

Phezam can provoke irritation in the epigastric region, when it is used after eating, there may be a decrease in the severity of gastric irritation, for which the medicine should be carefully used by patients suffering from gastrointestinal diseases.

It should be noted that the composition of the product as an auxiliary component contains lactose .

Phezam's analogs

Level 4 ATX code matches:

Both Phezam and its analogues should be prescribed by a doctor after an accurate diagnosis. Active ingredients similar to those contained in Phezam are included in the preparations Combitropil , , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.

Also, drugs have a similar pharmacological effect on the patient's body:, Vinpocetine , Demanol , Memotropil , Combitropil , Pantogam , Pyriditol , Cellex , Encephabol and etc.

Omaron or Phezam - which is better?

The tool is an analogue of this drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the medicine Omaron is lower compared to Phezam.

Alcohol compatibility

Alcohol and Phezam cannot be used at the same time, according to the instructions for the drug. When taken simultaneously, the risk of stroke increases, and there is also a negative effect on the liver. Therefore, during the treatment period you need to completely abstain from alcohol.

For children

These capsules are not prescribed to children under 5 years of age. Children after 5 years of age should be given the medicine strictly according to the scheme prescribed by the doctor. Reviews of doctors and parents indicate that with the help of this medicine in school-age children, you can normalize sleep, improve performance, and relieve irritability.

During pregnancy and lactation

The use of Phezam during pregnancy is contraindicated, although there is no information on the negative effect of the active components. Piracetam passes into breast milk, so the drug should not be used during lactation.

Thank you

Fezam is a combined drug from the group of nootropics that improve cerebral circulation and, as a result, brain function. The drug is used in the treatment of cerebral circulation disorders (for example, vascular atherosclerosis, cerebrovascular insufficiency), strokes, encephalopathies of various origins (for example, against the background of hypertension, traumatic brain injuries, previous infections, etc.), dementia (dementia) of vascular origin, disorders of memory, attention and mental work, as well as labyrinthopathy, Meniere's syndrome and neurological pathology of childhood.

Composition, names and release forms of Phezam

Currently, Fezam is produced in a single dosage form - capsules for oral administration. Often these capsules are called tablets, which is incorrect from a scientific point of view, but is quite suitable for designating a dosage form intended for oral administration. However, it should be remembered that when people say "Phezam tablets", they mean exactly the form for oral administration, that is, capsules. In addition, there is a common misnomer for the drug "Phezama", which is often used in everyday speech. Therefore, when you hear the term "Phezam", you should know that we are talking about the drug "Phezam".

Phezam contains two active components:
1. Cinnarizine - 25 mg;
2. Piracetam - 400 mg.

This means that each capsule contains 400 mg of Piracetam and 25 mg of Cinnarizine. Due to this content of active substances, the drug is often called "Phezam 400 + 25" in the slang of medical workers. When a person sees a similar name, do not be afraid, since we are talking about the same Fezam.

Phezam contains the following substances as auxiliary components:

Colloidal silicon dioxide;
Magnesium stearate.

The capsule shell consists of 98% gelatin and 2% titanium dioxide dye.

Fezam - mechanisms of action and scope of therapeutic use

Since Phezam is a combination drug that includes two active components, we will consider the properties of each of them and their resulting combined effect.

Piracetam is a nootropic agent that improves brain activity, having a positive effect on metabolic processes. Piracetam increases the rate of consumption of glucose, which is the main nutrient for the brain, since the cells of the central nervous system are not able to receive the energy necessary to maintain life and function from any other compounds. That is, brain cells under the influence of Piracetam begin to actively feed, producing more energy, which is quite enough to ensure intensive functioning of the organ. It is thanks to this that the speed of impulse transmission between neurons increases, memory is activated, attention is concentrated and a general improvement in intellectual function occurs.

Cinnarizine is a substance that has a pronounced effect directly on the blood vessels of the brain. Thus, cinnarizine dilates the blood vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances that constrict blood vessels. Cinnarizine dilates blood vessels, due to which blood flow is activated, and the supply of oxygen and nutrients to various parts of the brain is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissue to lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and blood pressure.

Phezam - indications for use (what Phezam tablets are for)

Currently, Fezam is indicated for use in the treatment of various diseases and conditions associated with cerebrovascular accidents, injuries, and disorders of integrative function. However, not all of these conditions are included in the list of official indications for the use of the drug, since their effectiveness has not been scientifically proven. Therefore, we provide only a list of approved, official indications for the use of Phezam.

So, the indications for the use of Phezam are the treatment of the following diseases or conditions:

Cerebral circulation disorders of any origin (cerebral atherosclerosis, subacute or chronic stroke, recovery period after hemorrhagic stroke, traumatic brain injury, osteochondrosis of the cervical spine, etc.);
Recovery after a traumatic brain injury;
Memory impairment;
Impaired thinking function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or think about a situation from different points of view, etc.);
Poor concentration;
Mood disorders;
Intoxication of any origin;
Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
Encephalopathy of various origins (due to chronic hypertension, traumatic brain injury, previous infection, surgery, anesthesia, etc.);
Dementia (dementia) caused by vascular pathology;
Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
Labyrinthopathy (pathology of the structures of the inner ear), manifested by tinnitus, nausea, vomiting, nystagmus, motion sickness;
Meniere's syndrome;
Aphasia (speech impairment) caused by vascular pathology;
Prevention of kinetosis (motion sickness, seasickness, etc.);
Migraine prevention;
Mild neurological pathology in children (poor learning ability, low concentration, insufficient long-term memory, etc.);
In a comprehensive methodology for teaching children who have mental retardation.

Phezam (tablets) – instructions for use

Phezam capsules must be taken orally, swallowed whole, without chewing, without breaking the integrity of the shell, and without pouring the powder into a glass of water. The capsule should be taken with a small amount of water (at least half a glass) or any other liquid with the exception of carbonated sweet drinks, coffee and caffeine-containing energy drinks. For example, you can take Phezam capsules with mineral water, juice, tea, compote, fruit juice and other drinks. The only condition that liquid for drinking Phezam must satisfy is a low temperature, that is, the drink should not be hot, but warm or cool.

Phezam capsules can be taken at any convenient time, regardless of meals. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after meals. Moreover, a light snack is quite suitable as food, for example, an apple, banana or other fruit, a sandwich, a piece of meat, etc.

Phezam overdose

An overdose of Phezam during the entire period of use of the drug was recorded a very limited number of times. The drug is safe, and even exceeding the therapeutic dosage several times did not cause significant side effects that would force a person to stop taking Phezam. The only symptom of Phezam overdose in adults may be abdominal pain, which, as a rule, is well tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations or convulsions.

If any symptoms of overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at relieving discomfort. In addition, gastric lavage is recommended. An overdose of Phezam can also be reversed using hemodialysis.

Special instructions for the use of Phezam

Athletes should stop taking the drug 2 to 3 days before doping tests, since the cinnarizine contained in Fezam can give a positive test result.

In addition, the use of Phezam may give a false positive test result for the determination of radioactive iodine, since the capsule dye contains this microelement. Fezam also activates the thyroid gland, as a result of which a person may experience tremor (shaking) of various parts of the body and anxiety.

While using Phezam, you should be careful when working with various mechanisms, including when driving a car, since cinnarizine may cause drowsiness in the initial stages of therapy.

While taking Phezam, you should refrain from drinking alcohol, as this will provoke massive death of brain cells.

When using Phezam in people suffering from liver diseases, the activity of transaminases (AST, ALT) should be monitored once a week. If transaminase activity increases by more than 1.5 times the upper limit of normal, Phezam should be discontinued.

Use during pregnancy and lactation

Experiments on animals revealed the absence of any negative effects of Phezam on the growth and development of the fetus. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in a woman’s mental state, increased anxiety, lability of the emotional sphere and mood, which theoretically could have a negative impact on the course of pregnancy.

Since Phezam passes into milk, it is also contraindicated during breastfeeding. If a woman breastfeeding a child must take Phezam for some reason, then the baby should be switched to artificial formula.

Interaction with other drugs

Taking drugs that dilate blood vessels and reduce blood pressure leads to an increase in all the effects of Phezam. Accordingly, drugs that constrict blood vessels and increase blood pressure, on the contrary, weaken the effects of Phezam.

Phezam improves subjective tolerability of drugs from the group of neuroleptics and antidepressants.

Phezam: before or after meals - how to take

Fez for children

Phezam is used for therapy in children older than 5 years of age. If necessary, the use of Phezam in children from one year is allowed.

Fezam in children and adolescents normalizes sleep, eliminates nightmares, stops night awakenings, reduces fatigue, increases performance, both mental and physical, and also relieves irritability, emotional instability, mood lability and excessive vulnerability. In addition, Fezam reduces the frequency of headaches in children, improves adaptation in school or preschool groups, stabilizes and maintains normal blood pressure, preventing its fluctuations. In general, Fezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Fezam is used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist, not a psychiatrist, since it is not suitable for the treatment of severe mental illnesses, but can be successfully used to eliminate mild disorders.

Fezam - side effects

The side effects of Phezam include the following symptoms from various organs and systems:
1. From the central nervous system:

Hyperkinesis (twitching of limbs, excessive movements, etc.);

In this article you can read the instructions for use of the drug Fezam. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Phezam in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Phezam analogues in the presence of existing structural analogues. Use for the treatment of cerebrovascular insufficiency in adults, children, as well as during pregnancy and lactation. Compound.

Fezam- a combined drug with a pronounced antihypoxic, nootropic and vasodilating effect.

Piracetam is a nootropic drug. Activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission to the central nervous system and regional blood flow in the ischemic area.

Cinnarizine is a calcium channel blocker. Inhibits the entry of calcium ions into cells and reduces their content in the plasmalemma depot. Reduces the tone of the smooth muscles of arterioles, reduces their response to biogenic vasoconstrictors (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and increases the tone of the sympathetic nervous system. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity.

Compound

Piracetam + cinnarizine + excipients.

Pharmacokinetics

Quickly and completely absorbed from the gastrointestinal tract. Piracetam does not bind to plasma proteins. Penetrates into all organs and tissues, penetrates the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia. Cinnarizine is actively and completely metabolized. Piracetam is not metabolized. 1/3 of the metabolites are excreted in the urine, 2/3 in the feces.

Indications

cerebrovascular insufficiency (cerebral atherosclerosis, recovery period of ischemic and hemorrhagic strokes, after traumatic brain injury, encephalopathy of various origins);
intoxication;
diseases of the central nervous system, accompanied by a decrease in intellectual and mental functions (impaired memory, attention, mood);
psychoorganic syndrome with a predominance of symptoms of asthenia and adynamia;
asthenic syndrome;
labyrinthopathy;
Meniere's syndrome;
prevention of kinetosis;
migraine prevention;
delayed intellectual development in children.

Release forms

Capsules 400 mg + 25 mg (sometimes mistakenly called tablets, but there are no tablet forms of Phezam).

Instructions for use and dosage regimen

For adults, the drug is prescribed 1-2 capsules 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.

Children over 5 years old are prescribed 1-2 capsules 1-2 times a day (no more than 3 months).

Side effect

dyspepsia;
headache;
sleep disorders;
allergic reactions in the form of skin rash.

Contraindications

severe liver dysfunction;
severe renal dysfunction;
parkinsonism;
pregnancy;
lactation (breastfeeding);
children under 5 years of age;
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Fezam is contraindicated for use during pregnancy and lactation.

special instructions

In case of mild to moderate renal failure (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses of the drug should be increased.

In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.

You should avoid drinking alcohol while taking Phezam.

Phezam should be used with caution in patients with elevated intraocular pressure.

The drug can cause a positive reaction in athletes during a doping test, and it is also possible to change the results of the determination of radioactive iodine (the dyes in the capsule shell contain iodine).

Impact on the ability to drive vehicles and operate machinery

While taking the drug Phezam, patients should be careful when driving vehicles and working with machines and equipment.

Drug interactions

With simultaneous use with Phezam, it is possible to increase the sedative effect of drugs that depress the activity of the central nervous system, as well as ethanol (alcohol), nootropic and antihypertensive drugs.

When used simultaneously, vasodilators enhance the effect of Phezam.

Phezam improves the tolerability of antipsychotic drugs and tricyclic antidepressants.

Analogues of the drug Phezam

Structural analogues of the active substance:

Combitropil;
NooKam;
Omaron;
Piracesin.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Phezam is a combined drug, the effectiveness of which is aimed at increasing blood circulation and metabolism in this area. As active ingredients in the composition of the drug is cinnarizine and piracetam.

In this article, we will consider why doctors prescribe Phezam, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Phezam can be read in the comments.

Composition and release form

Phezam capsules contain two active ingredients - piracetam and cinnarizine.
The product contains additional ingredients: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

Clinico-pharmacological group: a drug that improves blood circulation and brain metabolism.

What does Fezam help with?

Among the main indications for the use of the drug are:

depressive states and psychoorganic syndrome;
psychogenic asthenia and labyrinthopathy;
ischemic stroke and other disorders in the cerebral circulation;
portal form of hypertension accompanied by encephalopathy;
intellectual underdevelopment in children;
prevention of kinetosis and migraine;
subcomatose and comatose states after brain injury and intoxication;
damage to the central nervous system accompanied by a decrease in mnestic and intellectual functions.

Pharmacological properties

The medicine activates blood circulation in the brain, improves visual and auditory function. The presence of piracetam in the composition enhances energy metabolism, accelerates protein reproduction and the breakdown of glucose. The work of cinnarizine is to increase the resistance of brain capillaries to hypoxia and dilate blood vessels. In this case, no change in pressure is observed.

The complex effect of active elements allows Phezam tablets to reduce blood viscosity and normalize the functioning of the vestibular apparatus. The medication has minor antihistamine properties and improves the elasticity of erythrocyte membranes.

Instructions for use

According to the instructions for use, Phezam must be taken orally, swallowing whole, without chewing, without breaking the integrity of the shell, and without pouring the powder into a glass of water. The capsule should be taken with a small amount of water (at least half a glass) or any other liquid with the exception of carbonated sweet drinks, coffee and caffeine-containing energy drinks.

For adults, the drug is prescribed 1-2 caps. 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.
Children over 5 years old are prescribed 1-2 caps. 1-2 times / day. The course of treatment is 1.5-3 months.

Contraindications

There are a number of contraindications for the use of Phezam:

Huntington's chorea.
Age up to 5 years.
Allergic reactions.
Psychomotor agitation.
Pregnancy and lactation.
Severe renal failure (with creatinine clearance below 20 ml per minute).
Severe liver failure.

Caution should be exercised when used in the following situations: the presence of Parkinson's disease, impaired renal or liver function, impaired hemostasis, bleeding.

Side effects

According to reviews, Fezam may cause side effects.

Allergic reactions: dermatitis, skin rash, swelling, itching, photosensitivity.
Digestive system: nausea, increased salivation, diarrhea, vomiting, abdominal pain.
Nervous system: nervousness, hyperkinesia, depression, drowsiness, dizziness, ataxia, headaches, insomnia, imbalance, agitation, confusion, hallucinations, anxiety.
Other side effects: increased sexual activity.

Pregnancy and lactation

Despite the lack of data on the presence of teratogenic effects of piracetam and cinnarizine, Phezam is contraindicated for use during pregnancy. Piracetam is excreted in breast milk, so if it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Analogues

Structural analogues of the active substance:

Combitropil;
NooKam;
Omaron;
Piracesin.

Attention: the use of analogues must be agreed with the attending physician.