Pimafucin clotrimazole ointment which is better. Clotrimazole or pimafucin: which is better and what is the difference (differences in composition, reviews from doctors)

This disease is popularly called thrush. The disease is recognizable by its symptoms. Men feel discomfort in the area of the genital head. The patient may feel a burning sensation and a cheesy, unpleasant discharge appears. There is an effective ointment for sale for thrush in men, and more than one.

Men are no less likely than women to become infected and develop candidiasis. If left untreated, the disease progresses and can develop into urethritis or candidal prostatitis. A man, as soon as he notices the first symptoms of the disease, should go to a urologist, get tested, and if the diagnosis is confirmed, the doctor will prescribe him treatment.

What reasons provoke this? What ointment to use for the treatment to be effective? Let's look at it in the article.

It's a fungus. It is transmitted through sexual intercourse without the use of protection, and occurs for other reasons. The ointment, among other means, effectively kills the fungus.

Interesting! Thrush is not a sexually transmitted disease.

Its symptoms are similar to many unpleasant diseases. If you get sick, immediate treatment is required. Choose the right drug. For example, ointment removes it perfectly in the shortest possible time.

Most often, thrush at the initial stage is located on the head of the penis. In addition, it extends to the foreskin. This disease does not cause any particular complications and the ointment cures it quickly.

If the stage is chronic, then only your doctor should select an ointment against thrush in men. Consult your urologist. Most often, the doctor will prescribe more than one ointment. They are easy to use and powerful.

Signs of the disease

Depending on the stage of the disease and the man’s immunity, the following symptoms may be observed:

When urination occurs, he feels itching with burning and pain.

The erection will be increased, but during sexual intercourse the man will feel the same pain with burning and itching.

There will be swelling at the foreskin and glans.

Partners will smell milk that has turned sour.

Under the very foreskin or on the head of the organ there will be a curdled discharge that is white with a gray tint. When you try to remove the discharge, there may be erosions or wounds in that place. The sores may even bleed. Treatment required.

Doctor says:“Thrush is transmitted to a man from a woman, and it is important for both to monitor their health and treat the disease in a timely manner.”

Causes of the disease

Sexual intercourse without protection is only one of the reasons for infection and why thrush occurs. In any case, treatment is required.

Interesting! If a man has a strong immune system and is not sick with other sexually transmitted infections, there are no various diseases of internal organs in a chronic form, thrush can be cured by self-cleansing.

If you have symptoms of this disease, immediately go to see a urologist. He will examine you, question you and make the correct diagnosis. Prescribe effective treatment.

Thrush is transmitted not only as a fungus from partner to partner, there are other causes:

Problems in the endocrine system;

Diabetes;

You are overweight and your groin sweats more, which is a good breeding ground for fungus;

Metabolism is impaired;

Hypovitaminosis;

Diseases of the gastrointestinal tract;

With stress and nervous overload, a mild degree of illness develops;

If after drinking alcohol you feel a burning sensation in the groin area, it means that you have thrush in the early stages and need treatment.

Do not rush to blame your partner for the infection. The cause of the disease will be determined by the doctor after a complete examination.

Thrush ointments for men

The structure of the male genital organs is such that thrush will not hide anywhere, it will be on the surface and does not appear as often as in women. It's easier to treat. Every third person infected with candidiasis develops this disease “secretly” and insidiously. Timely and rapid treatment is required.

In its chronic form, thrush often provokes inflammation of the appendages. A man should know that by the time symptoms appear, the infection will have been in the body for a long time.

Symptoms that should alert you are pain when urinating, when there is a burning sensation on the head and foreskin and swelling is observed. It happens that the head becomes covered with a white film, and underneath there may be a rash. Urgent treatment is required.

The ointment has both advantages and disadvantages. It quickly destroys thrush. The ointment is convenient to apply to the organ. This is truly a very effective drug.

Important! The ointment for thrush works very quickly and the man feels relief. The symptoms are not so obvious. Treatment, thanks to this remedy, will go faster.

This is local therapy and the risk of any complications is very low. Ointment for men against candidiasis is not expensive. This is an excellent drug, competitive with other anti-fungal agents.

Unfortunately, ointments most often contain only a few ingredients and the fungus cannot be completely cured with one application to the organ. Carry out treatment systematically. A man should lubricate the affected areas with the product constantly for some time, as described in the instructions.

The best ointments

The fungus is treated with various antimycotic drugs.

These include ointments with creams, and a product that is sold in the form of a solution. The doctor will prescribe the treatment when a specific remedy is used.

The most effective drug “Pimafucin” with “Clotrimazole” and “Triderm” are different. The man who uses them will soon be healthy.

If you have a chronic form of candidiasis and you have used all these remedies and there is no desired effect, pay attention to the ointment for the treatment of thrush in men: “Flucostat” with “Diflucan” and other potent agents.

Advice. Man, use the drug that your doctor prescribes to you.

Clotrimazole

Imidazole is part of this drug. Even a small amount of Clotrimazole can slow down the development of fungi and kill the infection. The ointment for thrush will accumulate on the mucous membrane in the place where you use it and, due to its high concentration, the fungus will most likely be destroyed. What an effective remedy this is!

A man should apply the cream to the foreskin 2 or 3 times a day. Use the product regularly for a week and complete recovery from the fungus should occur.

Advice. Regarding the regimen of use and dosage, consult your doctor. When you use the medicine as prescribed by your doctor, there should be no side effects.

Nystatin ointment

Excellent ointment for candidiasis. It treats thrush well, including those caused by long-term use of antibiotics.

Apply the product to the affected area every day and 2 times. Let the ointment be on the affected area in a thin layer. Your doctor will prescribe the course of treatment. It can take from 2-3 days to 3 or 4 weeks.

If you have an allergy while using this drug, consult your doctor. Let him cancel this ointment and prescribe another one.

Ecodax

The drug "Ecodax" is produced in the form of a cream. The product should be rubbed into the affected area of the mucous membrane and skin.

Its composition is similar to imidazole and is used in a similar way. The product is applied topically and the effect is visible after 3 days of use.

If the ointment causes allergies by any of its components, it should not be used.

Pimafucin

This is an excellent ointment for men with thrush. It contains an antibiotic.

It acts as an antifungal agent. Natamycin is the main component.

The ointment perfectly kills candida fungi. Use Pimafucin 1 or 2 times a day.

Apply the drug externally. The course of treatment will be prescribed by the doctor. Most often this happens 3-7 days.

Doctor says:“When there are no longer visible traces of fungus on the genitals, continue to apply the drug for another 2-3 days.”

It is important that all symptoms disappear and discomfort goes away. To do this, listen to your doctor's advice. Follow the plan, follow the recommendations and be healthy.

Now you know that not everyone who becomes infected with a fungus from a partner gets sick, but only every third person. This is due to the fact that those who have stronger immunity clear themselves of candidiasis. They don't need any medicine.

When a person suffers from another sexually transmitted infection or has various diseases of the internal organs, his immunity is weakened and he becomes infected with this fungus. If you are sick, immediately use the ointment for thrush prescribed by your doctor for men.

Take good care of your health.
When you have intimate contact with a new partner, be sure to protect yourself with a condom. This will significantly reduce the risk of getting thrush.
Lead a healthy lifestyle.
Eat a lot of salads and fresh fruits.
If you smoke, try to quit.
Do not drink alcohol or even low-alcohol drinks frequently.

No one will take care of your health better than you!

Or thrush are creams and ointments that allow you to get rid of the disease in a short time. The use of a particular ointment is prescribed by a doctor depending on the clinical picture of each specific case of the disease. The ointment is a common medicine; it is absorbed into the blood differently and can have a therapeutic effect on the body as a whole. Pregnant women should use ointments and creams for thrush only after medical consultation. The most commonly prescribed ointments for thrush are clotrimazole and pimafucin.

Clotrimazole for thrush

Clotrimazole is a powerful antifungal agent. When it enters the human body, it finds the source of the disease, that is, Candida, and destroys its cell membranes. The fungus itself becomes unviable. Using the ointment in small quantities will block the spread of cells throughout the vaginal mucosa; a large dose of the drug will lead to their complete destruction. Clotrimazole ointment is applied at least twice a day. It should be carefully rubbed into damaged areas of the mucous membrane. After using the product, it is recommended to lie down for 15-20 minutes until it is completely absorbed. Sexual intercourse during treatment is not contraindicated, but it is best to abstain from it. In addition, the sexual partner should also undergo treatment, since thrush is transmitted through sexual contact.

Clotrimazole ointment is contraindicated in the first trimester of pregnancy, as well as when breastfeeding a child. In rare cases of using the drug, side effects appear in the form of burning, itching and redness at the sites of its local application. An overdose of the drug is not possible due to its local use. There are no contraindications for use. Clotrimazole ointment can be used with other medications, but it helps reduce the effect of some antibiotics, including nystatin. If no positive trends in the treatment of thrush are observed within a month of using the drug, you should seek the help of a specialist.

In most cases, clotrimazole is able to eliminate the main symptoms of thrush, however, to completely destroy the fungus, complex treatment with tablets and ointments should most often be used. If thrush has not been completely cured, it will appear again in the near future. Often, when treating thrush with ointment, an improvement in the condition is observed already in the first days of its use, but this is not a reason to abandon treatment. You should definitely complete the course prescribed by your doctor.

Pimafucin for thrush

The main active component of pimafucin is a special substance - natamycin; the auxiliary components are potato starch, calcium carbonate, talc, titanium oxide, sucrase, etc. Pimafucin is an antifungal antibiotic from the macrolide group and has a fungicidal effect. Natamycin has a destructive effect on the membrane cells of microorganisms, thereby completely destroying them. The period of treatment with the drug is determined depending on each specific case of the disease. After the main signs of thrush disappear, it is recommended to use the cream for several more days.

A large number of women, including pregnant women, with various diagnoses of diseases caused by fungi, including thrush, took part in clinical trials of pimafucin. A positive result occurred already in the first days of using the drug in 95% of patients. The results of the studies also proved the high effectiveness of the drug in the treatment of recurrent candidiasis. After only 3 days of using the ointment, pregnant patients observed the disappearance of the main signs of thrush, the well-being and condition of the fetus improved, and in some cases the symptoms of threatened miscarriage were eliminated. A further microbiological study of vaginal discharge showed a complete absence of fungal cells and its spores. The result was unsatisfactory in women who had repeatedly suffered from thrush and underwent repeated courses of medication, which could provoke the development of resistance of this infection to treatment with traditional antifungal drugs.

Pimafucin cream is applied topically, by gently rubbing into the affected areas of the skin and mucous membrane, at least 2 times a day. Long-term use of the cream does not have a negative effect on the vaginal mucosa. After applying the cream, it is recommended to lie down for a few minutes. The course of treatment lasts at least 7-9 days. In this case, it is recommended to treat thrush in a sexual partner, even in the absence of its main signs.

Pimafucin is one of the few drugs that are not contraindicated during pregnancy. The main active component of the drug is practically not absorbed from the gastrointestinal tract and mucous membranes, which means it does not enter the bloodstream and cannot affect the development of the fetus. Pimafucin cream is completely non-toxic and can be used even in late pregnancy and just before childbirth. The use of this drug can prevent the transmission of the disease from mother to child during its passage through the birth canal.

Side effects of the drug are very rare. Among them: diarrhea, nausea, burning and tingling in the area of application. The main contraindication to the use of pimafucin cream may be hypersensitivity to its main components. The drug is often used to treat thrush in newborns.

Pimafucin can be used not only for the treatment of vaginal candidiasis, but also candidiasis of the skin and nails, dermatomycosis, external. To date, an overdose of the drug has not been observed. Pimafucin is dispensed from pharmacies without a doctor's prescription.

It should be remembered that creams and ointments are medications, and therefore it is recommended to consult a specialist before using them. During pregnancy, this is the main condition for their use.

Suppositories for thrush are the most convenient way of local treatment of vaginal candidiasis in women. The effect of vaginal suppositories is due to the deep penetration of the active antifungal substance into the mucous membrane, which destroys the pathogen, eliminates inflammation, and reduces inflammation.

The pharmaceutical industry offers a wide range of different ones - these are both suppositories for local treatment and medications for oral administration, which are prescribed by a doctor for severe forms of candidiasis, for chronic thrush as part of complex therapy.

Which suppositories are best for thrush? There is one answer to this question - these are those drugs to which the candida fungus is sensitive based on the result of bacterial culture and determination of the resistance, resistance or sensitivity of the pathogen to a specific drug. Because in chronic, often relapsing cases, it may not be effective due to the development of drug resistance in fungal agents.

Uncontrolled, independent treatment of thrush leads to both the development of chronic candidiasis and disruption of the vaginal microflora. Moreover, many women actively practice this, which is not acceptable, since it only provokes further progression of the disease, further disrupting the vaginal microflora. Only the attending physician, based on the patient’s medical history, clinical picture, and taking into account the sensitivity of the pathogen, prescribes an adequate treatment regimen. Even if symptoms disappear, clinical recovery is considered to be the absence of fungi according to laboratory data over the next 3 months.

Rules for using suppositories against thrush

In the absence of therapy with a regular partner, a ping-pong effect occurs when a woman, after treatment, is again subjected to a fungal attack during unprotected sexual intercourse.

During therapy, you should either abstain from sexual intercourse or use condoms. Suppositories are inserted deep into the vagina at night to improve absorption of the drug.

When a woman is diagnosed with vaginal candidiasis, she and her doctor should analyze it, since without eliminating or minimizing the provoking factors, thrush can occur again and again.

Very often, candidiasis indicates the presence of other sexually transmitted infections (mycoplasmosis, gonorrhea, trichomoniasis, etc.) as well as the development of gardnerellosis ().

Depending on the intensity of the symptoms, acute or chronic process, treatment may differ in the course of therapy, in some cases it is enough to use 1 suppository, but in case of a chronic process this is not enough and longer treatment is required.

Vaginal suppositories should not be used during menstruation, with the exception of Povidone-Iodine (Iodoxide, Betadine) and Sertaconazole (Zalain).
The following suppositories can be used for 1 suppository: Zalain, Lomexin
3 suppositories each - Livarol, Gino-pevaril, Pimafucin.
5-14 suppositories each - Macmiror, Clotrimazole, Ginezol, Iodoxide, Nystatin, Polygynax, Terzhinan, Irunin.

During treatment, you should not wear synthetic, tight-fitting underwear, you must follow all the rules of intimate hygiene, change towels and linen daily, do not use chemicalized, scented pads, toilet paper, or intimate hygiene fluids, which only worsen the condition.

The best suppositories for thrush - Livarol, Pimafucin, Zalain, Nystatin, Clotrimazole, Lomixin, Macmiror - pros and cons of use

Sertaconazole - Zalain

Zalain(price 1 soup. 480-520 rubles, prices 2018)

It is a derivative of benzothiophene and imidazole.

Use during pregnancy: There is no sufficient data on the potential harm to the fetus during breastfeeding. But given the one-time method of use and the lack of systemic action of Zalain - during pregnancy, lactation, it is possible to use it in a situation where the expected benefit for the woman is higher than the possible risk for the child.
Contraindications: Hypersensitivity
Side effects: allergic reactions that do not require discontinuation of the drug.
Mode of application: 1 suppository for thrush is inserted into the vagina at night once; if symptoms persist, re-use is possible after a week. Before use, wash the external genitalia with neutral soap. Can be used during menstruation.
Advantages and disadvantages: The advantage of using Zalain for thrush is the one-time administration of the drug, high efficiency, the ability to use during menstruation, the disadvantage is the high price.

Ketoconazole - Livarol

Livarol (price 430 rubles for 5 pcs. 600-800 for 10 pcs.)
Ketoconazole 230-400 rub.

Contraindications: hypersensitivity, 1st trimester of pregnancy, in the 2nd-3rd trimester with caution.
Side effects: irritation, redness of the vaginal mucosa, itching. Skin rash, urticaria.
Application: In a lying position, 1 suppository is inserted deeply into the vagina for 3-5 days, for chronic thrush for 10 days.
Pros and cons: The advantage is the rapid effect, virtually no allergic reactions. It is most often prescribed when a diagnosis is first established; with frequent or prolonged use, drug resistance occurs in the pathogen.

Itraconazole - Irunin

Irunin - vaginal tablets 10 pcs. 300-320 rub.

Contraindications: 1st trimester of pregnancy, in the 2nd-3rd trimester with caution, hypersensitivity, lactation period
Side effects: itching, burning, skin rash that does not require discontinuation of the drug.
Application: at night for 7-14 days.
Pros and cons: An effective remedy for recurrent thrush and resistance to other antifungal agents, the disadvantage is that it cannot be used in the 1st trimester.

Nystatin + Nifuratel

(price 680 rubles for 8 pcs.)

Pregnancy: approved for use
Contraindications: hypersensitivity
Side effects: very rarely itching, skin rash
Application: Intravaginally, 1 suppository 8 days before bedtime.
Advantages and disadvantages: The main advantage of the possibility of therapy during pregnancy, the disadvantage is the high price.

(30-60 rubles 6 pieces),
Candide B6 (70 r), Antifungol, Kanesten,
Candizol, Yenamazole 100, Candibene.

Contraindications: increased sensitivity, it is strictly forbidden to use in the 1st trimester of pregnancy, while breastfeeding
Side effects: burning, itching, vaginal discharge, abdominal pain, headache, cystitis, frequent urination, pain during intercourse.
Mode of application: for 6 days, 1 suppository deep into the vagina at night.
Advantages and disadvantages: The advantage is that these are inexpensive suppositories against thrush, the disadvantage is frequent side effects, the rapid development of resistance in fungal agents.

Miconazole - Klion D, Neo-Penotran

Ginezol 7 (280-300 rubles), Gyno-dactanol, Daktarin, Mycozon (cream).
Combination drugs that contain, in addition to miconazole, metronidazole.

Klion-D 100 (price 330 rub.),
Neo-Penotran (14 pcs. 700 rub.),
Metromicon-Neo (14 pcs. 300-350 rub.)

Contraindications: hypersensitivity, with caution during pregnancy 2-3 trimester, lactation (suspend feeding during treatment) for diabetes, impaired liver function, herpes
Side effects: Only at the beginning of treatment there may be a feeling of discomfort, burning, itching, nausea, diarrhea, abdominal pain.
Mode of application: for 6-7 days, 1 suppository at night, you cannot drink alcohol during treatment.
Pros and cons: quick effect, wide spectrum of activity, does not cause dysbacteriosis, effective for frequent relapses of thrush, the disadvantage is the danger of use during pregnancy and feeding a child.

Econazole

Gyno-digester(3 pcs. 420 rub. 15 pcs. 800 rub.), Ifenek

Contraindications: hypersensitivity, pregnancy (1 tr.), since it penetrates into the systemic bloodstream, in 2-3 with caution, breastfeeding should be stopped during feeding.
Side effects: local irritation, rash, itching.
Application: suppositories 50 mg. within 14 days, even after the symptoms disappear, the course must be completed. Suppositories 150 mg. - within 3 days, if after 7 days the culture test gives a positive result, the course of treatment should be repeated.
Advantages and disadvantages: effective suppositories for thrush.

Natamycin - Pimafucin

Effect on the fetus: approved for use during pregnancy
Contraindications: increased individual sensitivity
Side effects: slight irritation
Mode of application: for 3-6 days, 1 suppository.
Advantages and disadvantages: The advantage of Pimafucin for thrush is that it has no effect on the fetus, which is why it is prescribed during pregnancy.

(30-60 rubles)
Complex preparations containing nystatin:

Polygynax (nystatin, neomycin, polymyxin B, price 6 pcs. 350 rub., 12 pcs. 600 rub.),
Terzhinan (prednisolone, neomycin, ternidazole, nystatin - 6 pcs. 360 rubles, 10 pcs. 450 rubles), but their use is fraught with the development of dysbacteriosis.

Contraindications: pregnancy of any stage, individual sensitivity
Side effects: chills, diarrhea, abdominal pain, vomiting, nausea
Mode of application: 2 times a day (morning and evening) for 10-14 days.
Pros and cons: The disadvantage of nystatin suppositories against candidiasis is the long course, use 2 times a day, and the presence of serious side effects. The advantage is that they are cheap; candida does not become resistant to nystatin, so it is often prescribed for chronic, recurrent candidiasis.

Povidone-iodine - Iodoxide

(10 pcs. 300 rub.), Betadine(price 7 pcs. 400 rub., 14 pcs. 500 rub.)

Contraindications: thyrotoxicosis, thyroid adenoma, with caution in case of renal failure, in case of individual sensitivity, not recommended during pregnancy, contraindicated in the 1st trimester, in the 2-3rd trimester and during lactation - with caution.
Side effects: allergic manifestations, local hyperemia
Mode of application: For acute vaginitis, 2 times a day for a week, 1 suppository, for chronic vaginitis, 1 time a day for 2 weeks, regardless of the phase of the menstrual cycle.
Pros and cons: can be used during menstruation, used in complex treatment for bacterial vaginosis.

Fenticonazole - Lomexin

(fenticonazole, price 1000 mg. 1 piece. 400 rub. 600 mg. 2 pieces. 600 rub.)

Contraindications: pregnancy, cannot be used during menstruation, if you are hypersensitive to the components of the suppository.
Side effects: mild symptoms of irritation that go away on their own and do not require discontinuation of the drug, allergic reactions - rash, urticaria, erythema
Mode of application: capsule 600 mg. are administered once; according to indications, if symptoms persist, use may be continued for 3 days. Capsules 1000 mg. administered within 2 days.
Advantages and disadvantages: effective remedy, cannot be used during pregnancy.

Dequalinium chloride - Fluomizin

Fluomizin - vaginal tablets 6 pcs. 560 rub. - antiseptic in gynecology (bacterial vaginosis, candidal vaginitis, sanitation before childbirth and operations)

Contraindications: ulcerative lesions of the cervix and vagina, girls before sexual activity, pregnancy 1-2 trimester - no data on the safety of use
Side effects: symptoms of irritation, allergic reactions - rash, urticaria, erythema
Mode of application: capsule at night, for 6 days, stop treatment during menstruation, continue after.

In addition to suppositories, it is possible to use creams with antifungal drugs:

Clotrimazole - Candide (with applicator 80 rubles), Clotrimazole cream 120 rubles, Kanizon 80 rubles.
Econazole – Ecodax cream 140 RUR
Isoconazole - Travogen cream 500-700 rub.
Fenticonazole - Lomexin cream 600 rub.
Butoconazole - Gynofort cream with applicator 600-700 rub.

For chronic recurrent thrush, it is necessary to take antifungal drugs orally:

Fluconazole 40-50 rubles (and more expensive analogues Flucostat, Mikomax, Mikosist, Diflucan)
Tinidazole 30-70 rub.
Ketoconazole – Mycozoral 460 RUR
Itraconazole - Irunin 320 rubles, Itrazol 380 rubles, Orungamin.

After antifungal therapy, the doctor may prescribe medications to normalize the vaginal microflora, that is, create conditions for the growth of lactobacilli in the vagina:

Vagilak 2 times a day (suppositories with bifidobacteria) for 5-10 days.
Laktozhinal, Acylact (lactobacteria) vaginal capsules for 1-10 days.
For oral administration - Bificol 10 days.

Advantages and disadvantages of using suppositories for thrush

Advantages of using topical medications for candidiasis in women:

When the drug is administered to a place where fungi actively multiply, the effect of local treatment appears much faster, especially when using modern effective drugs such as Livarol or Zalain.
Modern antifungal agents can be used once.
Because systemic absorption of topical medications is low, the incidence of side effects is reduced, unlike oral therapy.

Disadvantages of local treatment:

Local treatment causes some inconvenience to a woman - it stains her underwear and limits her sex life.
A positive effect from such therapy is possible only in mild forms of thrush, but when the course of the disease is more severe and prolonged, local therapy should be supplemented with the use of. Therefore, it is often necessary to repeat the course of treatment after a certain time.
When using combined antimicrobial drugs, such as Terzhinan, Polygynax, a common side effect is vaginal dysbiosis, which then requires additional treatment, for example, the use of suppositories with lactobacilli - Lactonorma, Acylact, Lactobacterin, Ecofemin or Vagiflora.

Suppositories for thrush during pregnancy

Very often, thrush occurs in women during pregnancy due to a physiological decrease in immunity, and many drugs either categorically cannot be used, or reliable studies of safety for the fetus have not been carried out. Among the entire selection of local drugs, the following suppositories are approved for use:

Suppositories - Pimafucin, Primafungin (active ingredient Natamycin).
Combined drug - Macmiror complex (active ingredients Nystatin and Nifuratel).

In the 2-3 trimesters Clotrimazole, Nystatin (low effectiveness) or the ancient remedy Borax in glycerin (Sodium tetraborate in glycerin), Pimafucin, Gino-Pevaril, Ginofort (vaginal cream), all these drugs are used during pregnancy with caution if there is a potential risk for the health of the mother exceeds the risk for the child.

Some doctors prescribe a combination drug - Terzhinan (prednisolone, neomycin, ternidazole, nystatin), but the instructions for it indicate that from the 2nd trimester it can only be used when assessing the potential benefit to the mother and harm to the fetus, since it has undesirable side effects and contains a hormonal drug - prednisolone.

For vaginosis, which is caused by the yeast-like fungus Candida, doctors usually prescribe the drugs Clotrimazole or Pimafucin. Doctors consider them the most effective in this situation. But in order to determine what is more effective, it is necessary to study in detail the composition of each drug, as well as the spectrum of action and other features. What is better, “Pimafucin” or “Clotrimazole” for thrush?

Properties

The effectiveness of therapy with one or another medication depends on the characteristics of the body and the severity of the fungal infection. What is "Pimafucin" from?

Fungi can appear in large quantities in the body, which sometimes exceeds the permissible level. It is difficult to cope with this without pharmacological treatment. Specialized drugs help to significantly reduce their number. But at the same time, it is necessary to follow a diet, as well as hygiene rules and other advice from a medical specialist.

In order for the elimination of the fungus to be most effective, in addition to drug treatment, the diet should be adjusted.

One of the common indications for the use of Clotrimazole and Pimafucin is candidiasis. This is a fungal disease that appears in the absence of hygiene, as a result of chronic infections. Candidiasis happens:

nail;
vaginal;
oral.

Both drugs are based on imidazole and polyene antimicrobial agents. The substances of the drugs help not only to suppress fungal activity, but to prevent the fungus from spreading further. They are used in the treatment of fungal infections of the vagina, male penis, and skin.

If we are talking about sexual diseases, then if one person is infected, both partners should undergo therapy. What is "Pimafucin" from? The active ingredients of the two medications are different. The active microelement of Pimafucin is natamycin, and the second drug contains clotrimazole.

"Clotrimazole" is not suitable for general use, since it is immediately eliminated from the body.

"Clotrimazole"

According to the instructions for use, Clotrimazole tablets appeared in the seventies of the last century. The active component disrupts the cell membrane of the fungus and key substances are released from it, which helps eliminate fungal cells. The drug affects various pathogens:

Candida fungi;
staphylococci;
streptococci.

Candida fungi are most sensitive to the drug. Clinical studies have confirmed that it is a safe and effective treatment for thrush.

According to the instructions for use, Clotrimazole tablets are not suitable for systemic treatment, since the drug is eliminated from the body almost immediately, and increasing the dosage can provoke intoxication of the body.

"Pimafucin"

The active ingredient is natamycin, it is considered a natural antimicrobial substance. "Pimafucin" is an antifungal drug produced by actinobacteria. Its effect is aimed at ergosterol, with which the microelement binds, as a result of which it prevents the growth of fungal elements.

Natamycin is not absorbed by the mucous cavities of the gastrointestinal tract; with prolonged use of the medication, addiction to it does not occur.

"Pimafucin" eliminates the following fungi:

nail;
vaginal;
cutaneous;
urethral.

The comparison of Clotrimazole and Pimafucin is based on the following statements.

Both drugs belong to the same therapeutic group - antifungal drugs. They differ in active ingredients. The drug based on natamycin has the following forms:

vaginal suppositories;
ointment;
capsules.

The second drug has more dosage forms. These are gel, cream, ointment, suppositories, vaginal tablets, solution for external application, granules and powder. Both drugs were created to eliminate fungal infections.

How are medications similar?

"Pimafucin" and "Clotrimazole" have the following similar characteristics:

They are used for the treatment of candidiasis and other fungal diseases in both mild and severe forms.
Available from pharmacies without a prescription.
Various release forms.

Both drugs belong to the same therapeutic group.

What is the difference between Clotrimazole and Pimafucin?

In addition to similarities, there are also certain differences between the drugs. These include:

Natamycin has a milder effect and practically does not penetrate into the blood when used.
"Pimafucin" can be used throughout pregnancy in the absence of sensitivity to the substance, while the second drug can be used in the second and third trimester.

Pimafucin and Clotrimazole contain different active ingredients. "Pimafucin" acts more gently; during use, the drug practically does not penetrate into the blood. "Clotrimazole" does not have a tablet form for oral use.

The indications for use of the two medications also differ, but not significantly, and the probable adverse reactions also differ.

The cost of drugs also varies, but the differences here largely depend on the manufacturer. What are the instructions for use and the price of Pimafucin and Clotrimazole?

Russian-made drugs are much cheaper than foreign ones, but have a similar effect. "Pimafucin" - from 200 to 700 rubles, "Clotrimazole" - from 20 to 260 rubles.

Which is cheaper?

The price and instructions for use for Pimafucin and Clotrimazole depend on the manufacturer. For example, a foreign-made Clotrimazole cream can cost up to two hundred rubles, while an ointment with the same name from a domestic manufacturer is slightly cheaper. Another medicine in the form of a cream will cost more.

The differences also relate to the cost of the drug for vaginal use. For example, vaginal tablets "Clotrimazole" cost about fifty rubles, and suppositories with a different name cost up to five hundred rubles.

Which is better: "Clotrimazole" or "Pimafucin"

The pharmacological effect and impact of a drug on healthy organs largely depend on how the body reacts to the substances of a particular drug. It is also necessary to take into account whether the patient has other diseases or pathological processes in which it is not recommended to use both medications, or it is possible, but under the strict supervision of a doctor.

For candidiasis

Both medications are recommended for thrush. But it is difficult to determine exactly what works more effectively. The impact depends on the form of the disease - acute or recurrent, and whether the person suffers from diabetes or other diseases.

For vaginal candidiasis, local therapy is usually prescribed: suppositories, vaginal tablets, ointments.

If a woman is diagnosed with thrush, she is prescribed local antifungal medications: suppositories, tablets, creams or ointments. In other situations, the decision is made by a medical specialist on an individual basis.

From actinomycosis (fungal infection)

When choosing a liniment for a skin fungus, you should take into account the characteristics of the body and the prohibitions on the use of a particular medication. These include both of the drugs under consideration. They work best in treating yeast infections on the arms, legs and body.

Clotrimazole ointment is considered a representative of the pharmacological group of antifungal drugs for external use. They are used for treatment that is aimed at eliminating the source of the infectious process caused by drug-sensitive pathogens.

Its antifungal effect is to inhibit the growth and spread of fungal cells with their subsequent elimination due to disruption of the formation of ergosterol, which is the main component of the fungal cell wall.

This leads to a change in permeability, followed by its elimination and death of the fungal cell. In low concentrations, Clotrimazole inhibits the growth and reproduction of the fungus; in higher dosages, it leads to the destruction and death of the fungal cell.

In large dosages, the active component of the drug provokes a change in metabolic processes in the mitochondria of fungal cells with an increase in the intracellular level of hydrogen peroxide. The medication has increased activity against yeast-like and mold fungi, as well as dermatophytes, sources of pityriasis rosea and erythrasma.

Pimafucin cream is a topical antifungal drug.

Liniment is an antimycotic antimicrobial agent with a wide spectrum of effects. Under the influence of the active substance, the growth and spread of fungi and other pathogens sensitive to Natamycin is suppressed. The drug destroys the membrane of the fungus, gets inside and provokes the death of the pathological element.

Yeast-like fungi of the genus Candida are considered the most sensitive to the drug, and dermatophytes are the least sensitive.

There is no information on the use of the medicine among children under one year of age, so before therapy you should definitely consult a medical specialist. Which is better: Clotrimazole or Pimafucin?

When eliminating vaginal candidiasis in women, it is best to simultaneously undergo a course of therapy with her sexual partner, otherwise the disease will continue to be transmitted to each other. During treatment with Pimafucin for fungal infections of the genital organs, it is necessary to refrain from intimacy.

During pregnancy

For women during an “interesting situation,” experts usually recommend these medications for treatment and prophylactic purposes to prevent thrush in the form of creams, vaginal suppositories or ointments.

But it must be taken into account that Pimafucin should be used in all trimesters of pregnancy, and the second medication should be used only in the second and third trimester. In addition, suppositories can be prescribed before childbirth to reduce the risk of a fungal infection in the baby as it passes through the birth canal. It is difficult to accurately determine which is better: Clotrimazole or Pimafucin - both drugs are effective in their own way.

For women

Women use drugs in any form, as a rule, for the purpose of treatment and prevention of candidiasis and other fungal infections. A medication in the form of vaginal suppositories has been developed especially for women.

For men

Both medications are prescribed to men to prevent candidiasis balanoposthitis. With proper therapy, the disease goes away completely within fourteen days. When using Pimafucin cream, the itching and burning sensation decreases after a few days, the symptoms disappear completely within ten days. When using the second medication, they go away much faster - within about seven days.

A certain amount of fungi of the genus Candida is constantly present in the human body. Excessive proliferation of this opportunistic fungus is controlled by certain bacteria and the human immune system.

In some cases, when the bacterial flora is disrupted, which occurs when antibacterial agents are used or when the body’s protective functions are weakened, the fungal flora is activated. Activation of the reproduction processes of an opportunistic fungus leads to the appearance of candidiasis.

In some cases, the disease can appear up to 3-4 times a year. In such a situation, we can talk about the recurrent nature of the pathology. To treat mycotic infections, medications based on imidazole and polyene antibiotics are used. The most popular and widespread are Clotrimazole and Pimafucin.

Which is better Clotrimazole or Pimafucin? To answer this question, you should compare the drugs according to their chemical composition and their effect on the body.

What is this article about?

What is the difference between the drugs?

Both medications belong to the pharmacogroup of antifungal drugs. These medications have noticeable differences in their chemical composition. Clotrimazole is based on the active component of the same name, and the main active compound of Pimafucin is natamycin.

The release form of both drugs may be different, due to different methods of their use, which depend on the form of the disease.

Clotrimazole is produced in the form of ointment, gel, cream. Solution for external use. In addition, vaginal suppositories and tablets for intravaginal use are produced.

Both drugs have excellent antifungal effects. Therefore, choosing which one is better is quite difficult. The best option can only be determined by the attending physician, taking into account the research performed. In this case, the dermatologist or mycologist also takes into account the individual characteristics of the patient’s body when prescribing a drug.

Pimafucin is produced:

in the form of vaginal suppositories;
tablets intended for oral administration.

Medicines based on clotrimazole are produced by both domestic and foreign manufacturers. The most famous manufacturers of Clotrimazole in various forms are:

Sedate Health Care and Shreya Life Sciences are an Indian manufacturer.
Hyperion and Magistra C&C are a Romanian company.
GlaxoSmithKline Pharmaceuticals and Medana Pharma are manufacturers from Poland.
Akrikhin, Pharmakor Production, Synthesis and some others are domestic pharmaceutical companies.

Pimafucin is manufactured by the pharmaceutical company Astellas Pharma, and is marketed by the Italian company Temmler.

The difference in the effect of natamycin and clotrimazole on the body

Clotrimazole is an imidazole derivative. Its therapeutic effects have been clinically proven against dermatophytes, pathogenic yeast-like and dimorphic fungi, as well as against some types of gram-positive bacteria. With the further development of pharmacology, when new compounds of the imidazole series were obtained, clotrimazole was used as a standard for the antimycotic activity of compounds.

When ingested, this substance contributes to the occurrence of disturbances in the processes that ensure the synthesis of one of the main components of the cell wall of the fungal cell - ergosterol. As a result of these phenomena, the membrane of the mycotic cell is destroyed. In addition, in cell organelles under the influence of clotrimazole, a stop in the synthesis of amino acids, phospholipids and sterols is observed; the listed negative phenomena occurring in the fungus lead to its death and cell destruction.

Fungi belonging to the genus Candida are especially sensitive to the effects of the drug. In addition, a drug based on clotrimazole can be successfully used in the fight against pityriasis versicolor. In a large number of clinical studies, clotrimazole has demonstrated itself as a safe medication with high antifungal efficacy when applied topically for the treatment of cutaneous and vaginal candidiasis. This compound is unsuitable for systemic treatment due to its rapid elimination from the body. Increasing the permissible dosage makes this drug toxic for humans.

Natamycin is a natural antibiotic. This compound is produced by actinobacteria belonging to the genus Streptomycetes. The main purpose of the substance when it enters the body is to disrupt the synthesis of ergosterol, which is required by the mycotic cell to carry out vital biochemical processes.

Upon penetration into the site of pathology, natamycin binds to ergosterol, which disrupts a large number of metabolic reactions in fungal cells and leads to growth arrest and death.

Side effects and contraindications to the use of Pimafucin and Clotrimazole

The use of any antifungal compound of synthetic or natural origin in therapy can provoke the appearance of undesirable reactions in the patient. Such reactions may include the appearance of disorders in the functioning of the gastrointestinal tract; in addition, disturbances in the functioning of the central nervous system may occur. Quite often there is a decrease in the amount of hemoglobin in the blood.

During the initial period of treatment with Pimafucin, diarrhea may be recorded. The patient often feels nauseous. Usually, with further therapy, negative symptoms begin to gradually disappear.

When using Pimafucin topically, an allergic response to the drug as a whole or to the components contained in it may occur.

The main relative contraindications to the use of Clotrimazole and Pimafucin are significant impairment of the functional capabilities of the kidneys and liver. If these pathologies are present, a visit to a dermatologist is required, who, after an examination, will adjust the optimal dosage of any of the drugs for the patient.

It is prohibited to use both medications to treat mycotic lesions in the first trimester of pregnancy, and Clotrimazole ointment should not be used to treat patients under three years of age.

Features of the effects of drugs on the body

Both drugs can be used to treat women with vulvovaginal candidiasis or thrush. However, it is impossible to say for sure which medicine is better. The positive effect of the drug depends on the severity of the disease and the presence of concomitant pathologies.

For primary candidiasis, it is preferable to use topical dosage forms in the form of cream, vaginal tablets and suppositories.

Research has proven that in 87% the destruction of candida is achieved within 2 days after using Clotrimazole tablets, and 95% of the pathogenic flora is destroyed in the next few days.

When exposed to pathology with Pimafucin containing natamycin, about 88% of patients noted significant improvements in their condition. Their itching and other unpleasant sensations disappeared. 96% of women were cured of the disease within 6 days after starting therapy with 2% natamycin cream.

Clotrimazole or Pimafucin, which is better for men?

According to statistics, about 10-11% of men suffer from candidiasis. To treat this pathology, local forms of Clotrimazole and Pimafucin are used. The effectiveness of the drugs has been proven during clinical trials.

When treating a fungal disease with Pimafucin cream, after three days, 66% of patients experienced a decrease in the intensity of itching and burning. The patients were completely cured of the inflammatory process within 10 days. 100% recovery occurred in 97% of cases.

During clinical trials of Clotrimazole, 93% of men experienced relief, and symptoms almost completely disappeared 7 days after the start of therapy. About 73% of male patients were completely cured of the disease a week after starting a drug course of treatment for a fungal infection.

A good effect appears on the body when treating recurrent pathologies with Clotrimazole and Pimafucin in forms for local use, if they are combined with taking systemic antifungal drugs.

Cost of drugs, their analogues and reviews about them

Imported cream Clotrimazole in the Russian Federation costs from 160 to 185 rubles. Products from domestic manufacturers are priced 2-3 times lower. One tube of Pimafucin is significantly more expensive compared to Clotrimazole, its cost is twice as high.

Vaginal tablets cost about 50 rubles, Pimafucin in suppositories costs about 500 rubles for 6 pieces.

If hypersensitivity to clotrimazole or the components of the drug is detected, it can be replaced with analogues. Such remedies are Candide, Nystatin, Terzhinan and some others.

Analogs of Pimafucin that can be used during drug therapy are:

Pimafucort;
Primafungin;
Diflazon;
Lomexin;
Natatsin;